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Saturday, March 21, 2015

Mumbai (Bombay)


From Wikipedia, the free encyclopedia

Mumbai
मुंबई
Bombay
Metropolis
Skyscrapers lit up at night. A clock tower with a square base and an octagonal top. A wide building with central and surrounding domes. Wide skyscrapers at night. A brown arch with boats nearby.
Clockwise from top: Cuffe Parade skyline, the
Rajabai Clock Tower, Taj Mahal Hotel, Narima
Point and the Gateway of India

Country India India
State Maharashtra
District Mumbai City
Mumbai Suburban
Former name Bombay
Native Language Marathi
First settled 1507
Named for Mumbadevi
Government
 • Type Mayor–Council
 • Body MCGM
 • Mayor Snehal Ambekar (SS)
 • Municipal commissioner Sitaram Kunte[2]
Area[3]
 • Metropolis 603 km2 (233 sq mi)
 • Metro 4,355[3][4] km2 (1,681.5 sq mi)
Elevation 14 m (46 ft)
Population (2011)[5]
 • Metropolis 12,478,447
 • Rank 1st
 • Density 21,000/km2 (54,000/sq mi)
 • Urban 18,414,288 (1st)
 • Metro[6] 20,748,395
Demonym Mumbaikar
Time zone IST (UTC+5:30)
ZIP code(s) 400 001 to 400 107
Area code(s) +91-22
Vehicle registration MH 01–02–03–47
Website www.mcgm.gov.in

Mumbai (/mʊmˈb/; also known as Bombay) is the capital city of the Indian state of Maharashtra. It is the most populous city in India, most populous metropolitan area in India, and the eighth most populous city in the world, with an estimated city population of 18.4 million and metropolitan area population of 20.7 million as of 2011.[7] Along with the urban areas, including the cities of Navi Mumbai, Thane, Bhiwandi, Kalyan, it is one of the most populous urban regions in the world.[8] Mumbai lies on the west coast of India and has a deep natural harbour. In 2009, Mumbai was named an alpha world city.[9] It is also the wealthiest city in India,[10] and has the highest GDP of any city in South, West or Central Asia.[citation needed] Mumbai has the highest number of billionaires and millionaires than any other city in India.[11][12]

The seven islands that came to constitute Mumbai were home to communities of fishing colonies.[13] For centuries, the islands were under the control of successive indigenous empires before being ceded to the Portuguese and subsequently to the British East India Company when in 1661 King Charles II married the Portuguese Catherine of Braganza, and as part of her dowry Charles received the ports of Tangier and seven islands of Bombay.[14] During the mid-18th century, Bombay was reshaped by the Hornby Vellard project,[15][15] which undertook reclamation of the area between the seven islands from the sea.[16] Along with construction of major roads and railways, the reclamation project, completed in 1845, transformed Bombay into a major seaport on the Arabian Sea. Bombay in the 19th century was characterized by economic and educational development. During the early 20th century it became a strong base for the Indian independence movement. Upon India's independence in 1947 the city was incorporated into Bombay State. In 1960, following the Samyukta Maharashtra movement, a new state of Maharashtra was created with Bombay as the capital. The city was renamed Mumbai in 1996.[17]

Mumbai is the financial, commercial and entertainment capital of India. It is also one of the world's top ten centres of commerce in terms of global financial flow,[18] generating 6.16% of India's GDP[19] and accounting for 25% of industrial output, 70% of maritime trade in India (Mumbai Port Trust and JNPT),[20] and 70% of capital transactions to India's economy.[21] The city houses important financial institutions such as the Reserve Bank of India, the Bombay Stock Exchange, the National Stock Exchange of India, the SEBI and the corporate headquarters of numerous Indian companies and multinational corporations. It is also home to some of India's premier scientific and nuclear institutes like BARC, NPCL, IREL, TIFR, AERB, AECI, and the Department of Atomic Energy. The city also houses India's Hindi (Bollywood) and Marathi film and television industry. Mumbai's business opportunities, as well as its potential to offer a higher standard of living,[22] attract migrants from all over India, making the city a melting pot of many communities and cultures.

Etymology

The name Mumbai is derived from Mumba or Maha-Amba—the name of the Koli goddess Mumbadevi—and Aai, "mother" in the language of Marathi, the mother tongue of the Kolis and the official language of Maharashtra.[13][23]

The temple of local Hindu goddess Mumbadevi, from whom the city of Mumbai derives its name

The oldest known names for the city are Kakamuchee and Galajunkja; these are sometimes still used.[24][25] Ali Muhammad Khan, in the Mirat-i-Ahmedi (1507) referred to the city as Manbai.[26] In 1508, Portuguese writer Gaspar Correia used the name Bombaim, in his Lendas da Índia ("Legends of India").[27][28] This name possibly originated as the Old Portuguese phrase bom baim, meaning "good little bay",[29] and Bombaim is still commonly used in Portuguese.[30] In 1516, Portuguese explorer Duarte Barbosa used the name Tana-Maiambu: Tana appears to refer to the adjoining town of Thane and Maiambu to Mumbadevi.[31]

Other variations recorded in the 16th and the 17th centuries include: Mombayn (1525), Bombay (1538), Bombain (1552), Bombaym (1552), Monbaym (1554), Mombaim (1563), Mombaym (1644), Bambaye (1666), Bombaiim (1666), Bombeye (1676), Boon Bay (1690),[30][32] and Bon Bahia.[33] After the British gained possession of the city in the 17th century, the Portuguese name was officially anglicised as Bombay.[34]

By the late 20th century, the city was referred to as Mumbai or Mambai in Marathi, Konkani, Gujarati, Kannada and Sindhi, and as Bambai in Hindi, Persian and Urdu.[citation needed] The English name was officially changed to Mumbai in November 1995.[35] This came at the insistence of the Marathi nationalist Shiv Sena party that had just won the Maharashtra state elections and mirrored similar name changes across the country.[citation needed] According to Slate, "they argued that 'Bombay' was a corrupted English version of 'Mumbai' and an unwanted legacy of British colonial rule."[36] Slate also said "The push to rename Bombay was part of a larger movement to strengthen Marathi identity in the Maharashtra region."[37] While the city is still referred to as Bombay by some of its residents and Indians from other regions,[38] mention of the city by a name other than Mumbai has been controversial, resulting in emotional outbursts sometimes of a violently political nature.[39][40]

History

Early history

A white Buddhist stupa.
Kanheri Caves served as a centre of Buddhism in Western India during ancient times

Mumbai is built on what was once an archipelago of seven islands: Bombay Island, Parel, Mazagaon, Mahim, Colaba, Worli, and Old Woman's Island (also known as Little Colaba).[41] It is not exactly known when these islands were first inhabited. Pleistocene sediments found along the coastal areas around Kandivali in northern Mumbai suggest that the islands were inhabited since the Stone Age.[42] Perhaps at the beginning of the Common era (2,000 years ago), or possibly earlier, they came to be occupied by the Koli fishing community.[43]

In the third century BCE, the islands formed part of the Maurya Empire, during its expansion in the south, ruled by the Buddhist emperor, Ashoka of Magadha.[44] The Kanheri Caves in Borivali were excavated in the mid-third century BCE,[45] and served as an important centre of Buddhism in Western India during ancient Times.[46] The city then was known as Heptanesia (Ancient Greek: A Cluster of Seven Islands) to the Greek geographer Ptolemy in 150 CE.[47]

Between the second century BCE and ninth century CE, the islands came under the control of successive indigenous dynasties: Satavahanas, Western Kshatrapas, Abhiras, Vakatakas, Kalachuris, Konkan Mauryas, Chalukyas and Rashtrakutas,[48] before being ruled by the Silhara dynasty from 810 to 1260.[49] Some of the oldest edifices in the city built during this period are, Jogeshwari Caves (between 520 to 525),[50] Elephanta Caves (between the sixth to seventh century),[51] Walkeshwar Temple (10th century),[52] and Banganga Tank (12th century).[53]

The Haji Ali Dargah was built in 1431, when Mumbai was under the rule of the Gujarat Sultanate

King Bhimdev founded his kingdom in the region in the late 13th century and established his capital in Mahikawati (present day Mahim).[54] The Pathare Prabhus, among the earliest known settlers of the city, were brought to Mahikawati from Saurashtra in Gujarat around 1298 by Bhimdev.[55] The Delhi Sultanate annexed the islands in 1347–48 and controlled it until 1407. During this time, the islands were administered by the Muslim Governors of Gujarat, who were appointed by the Delhi Sultanate.[56][57]

The islands were later governed by the independent Gujarat Sultanate, which was established in 1407. The Sultanate's patronage led to the construction of many mosques, prominent being the Haji Ali Dargah in Worli, built in honour of the Muslim saint Haji Ali in 1431.[58] From 1429 to 1431, the islands were a source of contention between the Gujarat Sultanate and the Bahamani Sultanate of Deccan.[59][60] In 1493, Bahadur Khan Gilani of the Bahamani Sultanate attempted to conquer the islands but was defeated.[61]

Portuguese and British rule

The Madh Fort built by the Portuguese, was one of the most important forts in Salsette.

The Mughal Empire, founded in 1526, was the dominant power in the Indian subcontinent during the mid-16th century.[62] Growing apprehensive of the power of the Mughal emperor Humayun, Sultan Bahadur Shah of the Gujarat Sultanate was obliged to sign the Treaty of Bassein with the Portuguese Empire on 23 December 1534. According to the treaty, the seven islands of Bombay, the nearby strategic town of Bassein and its dependencies were offered to the Portuguese. The territories were later surrendered on 25 October 1535.[63]

The Portuguese were actively involved in the foundation and growth of their Roman Catholic religious orders in Bombay.[64] They called the islands by various names, which finally took the written form Bombaim. The islands were leased to several Portuguese officers during their regime. The Portuguese Franciscans and Jesuits built several churches in the city, prominent being the St. Michael's Church at Mahim (1534),[65] St. John the Baptist Church at Andheri (1579),[66] St. Andrew's Church at Bandra (1580),[67] and Gloria Church at Byculla (1632).[68] The Portuguese also built several fortifications around the city like the Bombay Castle, Castella de Aguada (Castelo da Aguada or Bandra Fort), and Madh Fort. The English were in constant struggle with the Portuguese vying for hegemony over Bombay, as they recognized its strategic natural harbour and its natural isolation from land-attacks.
By the middle of the 17th century the growing power of the Dutch Empire forced the English to acquire a station in western India. On 11 May 1661, the marriage treaty of Charles II of England and Catherine of Braganza, daughter of King John IV of Portugal, placed the islands in possession of the English Empire, as part of Catherine's dowry to Charles.[69] However, Salsette, Bassein, Mazagaon, Parel, Worli, Sion, Dharavi, and Wadala still remained under Portuguese possession. From 1665 to 1666, the English managed to acquire Mahim, Sion, Dharavi, and Wadala.[70]
In accordance with the Royal Charter of 27 March 1668, England leased these islands to the English East India Company in 1668 for a sum of £10 per annum.[71] The population quickly rose from 10,000 in 1661, to 60,000 in 1675.[72] The islands were subsequently attacked by Yakut Khan, the Siddi admiral of the Mughal Empire, in October 1672,[73] Rickloffe van Goen, the Governor-General of Dutch India on 20 February 1673,[74] and Siddi admiral Sambal on 10 October 1673.[73]

In 1687, the English East India Company transferred its headquarters from Surat to Bombay. The city eventually became the headquarters of the Bombay Presidency.[75] Following the transfer, Bombay was placed at the head of all the Company's establishments in India.[76] Towards the end of the 17th century, the islands again suffered incursions from Yakut Khan in 1689–90.[77] The Portuguese presence ended in Bombay when the Marathas under Peshwa Baji Rao I captured Salsette in 1737, and Bassein in 1739.[78] By the middle of the 18th century, Bombay began to grow into a major trading town, and received a huge influx of migrants from across India.[79] Later, the British occupied Salsette on 28 December 1774. With the Treaty of Surat (1775), the British formally gained control of Salsette and Bassein, resulting in the First Anglo-Maratha War.[80] The British were able to secure Salsette from the Marathas without violence through the Treaty of Purandar (1776),[81] and later through the Treaty of Salbai (1782), signed to settle the outcome of the First Anglo-Maratha War.[82]

Ships in Bombay Harbour (c. 1731). Bombay emerged as a significant trading town during the mid-18th century.

From 1782 onwards, the city was reshaped with large-scale civil engineering projects aimed at merging all the seven islands into a single amalgamated mass. This project, known as Hornby Vellard, was completed by 1784.[15] In 1817, the British East India Company under Mountstuart Elphinstone defeated Baji Rao II, the last of the Maratha Peshwa in the Battle of Khadki.[83] Following his defeat, almost the whole of the Deccan came under British suzerainty, and was incorporated into the Bombay Presidency. The success of the British campaign in the Deccan marked the liberation of Bombay from all attacks by native powers.[84]

By 1845, the seven islands coalesced into a single landmass by the Hornby Vellard project via large scale land reclamation.[16][85] On 16 April 1853, India's first passenger railway line was established, connecting Bombay to the neighbouring town of Thane.[86] During the American Civil War (1861–1865), the city became the world's chief cotton-trading market, resulting in a boom in the economy that subsequently enhanced the city's stature.[87]

The opening of the Suez Canal in 1869 transformed Bombay into one of the largest seaports on the Arabian Sea.[88] In September 1896, Bombay was hit by a bubonic plague epidemic where the death toll was estimated at 1,900 people per week.[89] About 850,000 people fled Bombay and the textile industry was adversely affected.[90] As the capital of the Bombay Presidency, the city witnessed the Indian independence movement, with the Quit India Movement in 1942 and The Royal Indian Navy Mutiny in 1946 being its most notable events.[91][92]

Independent India

A stone statue of torch-bearers as seen at night. A fountain with a white base is in the background
The Hutatma Chowk memorial, built to honour the martyrs of the Samyukta Maharashtra movement. (Flora Fountain is on its left in the background.)

After India's independence in 1947, the territory of the Bombay Presidency retained by India was restructured into Bombay State. The area of Bombay State increased, after several erstwhile princely states that joined the Indian union were integrated into the state. Subsequently, the city became the capital of Bombay State.[93] On April 1950, Municipal limits of Bombay were expanded by merging the Bombay Suburban District and Bombay City to form the Greater Bombay Municipal Corporation.[94]

The Samyukta Maharashtra movement to create a separate Maharashtra state including Bombay was at its height in the 1950s. In the Lok Sabha discussions in 1955, the Congress party demanded that the city be constituted as an autonomous city-state.[95] The States Reorganisation Committee recommended a bilingual state for Maharashtra–Gujarat with Bombay as its capital in its 1955 report. Bombay Citizens' Committee, an advocacy group of leading Gujarati industrialists lobbied for Bombay's independent status.[96]

Following protests during the movement in which 105 people were killed by police, Bombay State was reorganised on linguistic lines on 1 May 1960.[97] Gujarati-speaking areas of Bombay State were partitioned into the state of Gujarat.[98] Maharashtra State with Bombay as its capital was formed with the merger of Marathi-speaking areas of Bombay State, eight districts from Central Provinces and Berar, five districts from Hyderabad State, and numerous princely states enclosed between them.[99] As a memorial to the martyrs of the Samyukta Maharashtra movement, Flora Fountain was renamed as Hutatma Chowk (Martyr's Square), and a memorial was erected.[100]

The following decades saw massive expansion of the city and its suburbs. In the late 1960s, Nariman Point and Cuffe Parade were reclaimed and developed.[101] The Bombay Metropolitan Region Development Authority (BMRDA) was established on 26 January 1975 by the Government of Maharashtra as an apex body for planning and co-ordination of development activities in the Bombay metropolitan region.[102] In August 1979, a sister township of New Bombay was founded by the City and Industrial Development Corporation (CIDCO) across Thane and Raigad districts to help the dispersal and control of Bombay's population. The textile industry in Bombay largely disappeared after the widespread 1982 Great Bombay Textile Strike, in which nearly 250,000 workers in more than 50 textile mills went on strike.[103] Mumbai's defunct cotton mills have since become the focus of intense redevelopment.

The Jawaharlal Nehru Port, which currently handles 55–60% of India's containerised cargo, was commissioned on 26 May 1989 at Nhava Sheva with a view to de-congest Bombay Harbour and to serve as a hub port for the city.[104] The geographical limits of Greater Bombay were coextensive with municipal limits of Greater Bombay. On 1 October 1990, the Greater Bombay district was bifurcated to form two revenue districts namely, Bombay City and Bombay Suburban, though they were administered by same Municipal Administration.[105]

The past two decades have seen an increase in violence in the hitherto largely peaceful city. Following the demolition of the Babri Masjid in Ayodhya, the city was rocked by the Hindu-Muslim riots of 1992–93 in which more than 1,000 people were killed. On 12 March 1993, a series of 13 co-ordinated bombings at several city landmarks by Islamic extremists and the Bombay underworld resulted in 257 deaths and over 700 injuries.[106] In 2006, 209 people were killed and over 700 injured when seven bombs exploded on the city's commuter trains.[107] In 2008, a series of ten coordinated attacks by armed terrorists for three days resulted in 173 deaths, 308 injuries, and severe damage to several heritage landmarks and prestigious hotels.[108] The blasts that occurred at the Opera House, Zaveri Bazaar, and Dadar on 13 July 2011 were the latest in the series of terrorist attacks in Mumbai.[109]

Today, Mumbai is the commercial capital of India and has evolved into a global financial hub.[110] For several decades it has been the home of India's main financial services, and a focus for both infrastructure development and private investment.[111] From being an ancient fishing community and a colonial centre of trade, Mumbai has become South Asia's largest city and home of the world's most prolific film industry.[112]

Geography

Mumbai is on a narrow peninsula on the southwest of Salsette Island, which lies between the Arabian Sea to the west, Thane Creek to the east, and Vasai Creek to the north. Mumbai's suburban district occupies most of the island. Navi Mumbai is east of Thane Creek, and the Thane District is north of Vasai Creek.
Mumbai consists of two revenue districts

Mumbai metropolitan region, Landsat 5 satellite image, 2011-01-30

Mumbai consists of two distinct regions: Mumbai City district and Mumbai Suburban district, which form two separate revenue districts of Maharashtra.[113] The city district region is also commonly referred to as the Island City or South Mumbai.[19] The total area of Mumbai is 603.4 km2 (233 sq mi).[114] Of this, the island city spans 67.79 km2 (26 sq mi), while the suburban district spans 370 km2 (143 sq mi), together accounting for 437.71 km2 (169 sq mi) under the administration of Municipal Corporation of Greater Mumbai (MCGM). The remaining area belongs to Defence, Mumbai Port Trust, Atomic Energy Commission and Borivali National Park, which are out of the jurisdiction of the BMC.[115]

Mumbai lies at the mouth of the Ulhas River on the western coast of India, in the coastal region known as the Konkan. It sits on Salsette Island, partially shared with the Thane district.[116] Mumbai is bounded by the Arabian Sea to the west.[117] Many parts of the city lie just above sea level, with elevations ranging from 10 m (33 ft) to 15 m (49 ft);[118] the city has an average elevation of 14 m (46 ft).[119] Northern Mumbai (Salsette) is hilly,[120] and the highest point in the city is 450 m (1,476 ft) at Salsette in the PowaiKanheri ranges.[121] Sanjay Gandhi National Park (Borivali National Park) is located partly in the Mumbai suburban district, and partly in the Thane district, and it extends over an area of 103.09 km2 (39.80 sq mi).[122]

Apart from the Bhatsa Dam, there are six major lakes that supply water to the city: Vihar, Lower Vaitarna, Upper Vaitarna, Tulsi, Tansa and Powai. Tulsi Lake and Vihar Lake are located in Borivili National Park, within the city's limits. The supply from Powai lake, also within the city limits, is used only for agricultural and industrial purposes.[123] Three small rivers, the Dahisar River, Poinsar (or Poisar) and Ohiwara (or Oshiwara) originate within the park, while the polluted Mithi River originates from Tulsi Lake and gathers water overflowing from Vihar and Powai Lakes.[124] The coastline of the city is indented with numerous creeks and bays, stretching from Thane creek on the eastern to Madh Marve on the western front.[125] The eastern coast of Salsette Island is covered with large mangrove swamps, rich in biodiversity, while the western coast is mostly sandy and rocky.[126]

Soil cover in the city region is predominantly sandy due to its proximity to the sea. In the suburbs, the soil cover is largely alluvial and loamy.[127] The underlying rock of the region is composed of black Deccan basalt flows, and their acidic and basic variants dating back to the late Cretaceous and early Eocene eras.[128] Mumbai sits on a seismically active zone owing to the presence of 23 fault lines in the vicinity.[129] The area is classified as a Seismic Zone III region,[130] which means an earthquake of up to magnitude 6.5 on the Richter-scale may be expected.[131]

Climate

The average temperature ranges between 23 °C (73 °F) in January to 30 °C (86 °F) in May. Rainfall is at or near zero from November through May, then quickly rises to a peak of about 600 mm (23.62 in) in July, falling back more gradually.
Average temperature and precipitation in Mumbai

Mumbai has a tropical climate, specifically a tropical wet and dry climate (Aw) under the Köppen climate classification, with seven months of dryness and peak of rains in July.[132] The cooler season from December to February is followed by the summer season from March to June. The period from June to about the end of September constitutes the south-west monsoon season, and October and November form the post-monsoon season.[133]

Between June and September, the south west monsoon rains lash the city. Pre-monsoon showers are received in May. Occasionally, north-east monsoon showers occur in October and November. The maximum annual rainfall ever recorded was 3,452 mm (136 in) for 1954.[134] The highest rainfall recorded in a single day was 944 mm (37 in) on 26 July 2005.[135] The average total annual rainfall is 2,146.6 mm (85 in) for the Island City, and 2,457 mm (97 in) for the suburbs.[134]

The average annual temperature is 27.2 °C (81 °F), and the average annual precipitation is 2,167 mm (85 in).[136] In the Island City, the average maximum temperature is 31.2 °C (88 °F), while the average minimum temperature is 23.7 °C (75 °F). In the suburbs, the daily mean maximum temperature range from 29.1 °C (84 °F) to 33.3 °C (92 °F), while the daily mean minimum temperature ranges from 16.3 °C (61 °F) to 26.2 °C (79 °F).[134] The record high is 40.2 °C (104 °F) on 28 March 1982,[137] and the record low is 7.4 °C (45 °F) on 27 January 1962.[138]

Climate data for Mumbai (Chhatrapati Shivaji International Airport)
Month Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec Year
Record high °C (°F) 37.1
(98.8)
39.6
(103.3)
41.7
(107.1)
42.2
(108)
41.0
(105.8)
37.1
(98.8)
34.8
(94.6)
33.5
(92.3)
36.4
(97.5)
37.9
(100.2)
37.4
(99.3)
39.8
(103.6)
42.2
(108)
Average high °C (°F) 30.7
(87.3)
31.2
(88.2)
32.5
(90.5)
33.0
(91.4)
33.3
(91.9)
32.1
(89.8)
30.0
(86)
29.6
(85.3)
30.4
(86.7)
33.2
(91.8)
33.5
(92.3)
32.0
(89.6)
31.8
(89.2)
Average low °C (°F) 16.8
(62.2)
17.8
(64)
21.0
(69.8)
23.9
(75)
26.3
(79.3)
26.0
(78.8)
24.9
(76.8)
24.7
(76.5)
24.3
(75.7)
23.4
(74.1)
20.9
(69.6)
18.6
(65.5)
22.4
(72.3)
Record low °C (°F) 7.4
(45.3)
8.5
(47.3)
13.8
(56.8)
16.9
(62.4)
20.2
(68.4)
19.8
(67.6)
21.2
(70.2)
19.4
(66.9)
20.7
(69.3)
16.7
(62.1)
13.3
(55.9)
10.6
(51.1)
7.4
(45.3)
Rainfall mm (inches) 0.6
(0.024)
1.3
(0.051)
0.2
(0.008)
0.7
(0.028)
12.5
(0.492)
523.1
(20.594)
799.7
(31.484)
529.7
(20.854)
312.3
(12.295)
55.8
(2.197)
16.8
(0.661)
5.3
(0.209)
2,258
(88.898)
Avg. rainy days 0.1 0.1 0.0 0.1 0.7 14.5 23.2 21.4 14.4 3.0 1.0 0.4 78.9
 % humidity 69 67 69 71 70 80 86 86 83 78 71 69 75
Mean monthly sunshine hours 269.5 257.6 274.3 283.7 296.2 148.6 73.4 75.9 165.1 240.2 245.8 253.2 2,583.5
Source #1: India Meteorological Department (Period 1961–1990, record high and low up to 2010)[139][140]
Source #2: NOAA (humidity, sun 1971–1990) [141]

Economy

refer caption
The Bombay Stock Exchange is the oldest stock exchange in Asia.

Mumbai is India's largest city (by population) and is the financial and commercial capital of the country as it generates 6.16% of the total GDP.[19][110][142] It serves as an economic hub of India, contributing 10% of factory employment, 25% of industrial output, 33% of income tax collections, 60% of customs duty collections, 20% of central excise tax collections, 40% of India's foreign trade and INR4000 crore (US$630 million) in corporate taxes.[143] Along with the rest of India, Mumbai has witnessed an economic boom since the liberalisation of 1991, the finance boom in the mid-nineties and the IT, export, services and outsourcing boom in 2000s.[144] Although Mumbai had prominently figured as the hub of economic activity of India in the 1990s, the Mumbai Metropolitan Region is presently witnessing a reduction in its contribution to India's GDP.[145]

As of 2008, Mumbai's GDP is $209 billion,[146] and its per-capita (PPP) income in 2009 was INR486,000 (US$7,600),[10][147] which is almost three times the national average.[85] Its nominal per capita income is INR125,000 (US$2,000),[148] (US$2,094). Many of India's numerous conglomerates (including Larsen and Toubro, State Bank of India (SBI), Life Insurance Corporation of India (LIC), Tata Group, Godrej and Reliance),[110] and five of the Fortune Global 500 companies are based in Mumbai.[149] This is facilitated by the presence of the Reserve Bank of India (RBI), the Bombay Stock Exchange (BSE), the National Stock Exchange of India (NSE), and financial sector regulators such as the Securities and Exchange Board of India (SEBI).[145]

Until the 1970s, Mumbai owed its prosperity largely to textile mills and the seaport, but the local economy has since then diversified to include finance, engineering, diamond-polishing, healthcare and information technology.[150] The key sectors contributing to the city's economy are: finance, gems & jewellery, leather processing, IT and ITES, textiles, and entertainment. Nariman Point and Bandra Kurla Complex (BKC) are Mumbai's major financial centres.[145] Despite competition from Bangalore, Hyderabad and Pune, Mumbai has carved a niche for itself in the information technology industry. The Santacruz Electronic Export Processing Zone (SEEPZ) and the International Infotech Park (Navi Mumbai) offer excellent facilities to IT companies.[151]

State and central government employees make up a large percentage of the city's workforce. Mumbai also has a large unskilled and semi-skilled self-employed population, who primarily earn their livelihood as hawkers, taxi drivers, mechanics and other such blue collar professions. The port and shipping industry is well established, with Mumbai Port being one of the oldest and most significant ports in India.[152] Dharavi, in central Mumbai, has an increasingly large recycling industry, processing recyclable waste from other parts of the city; the district has an estimated 15,000 single-room factories.[153]

Mumbai has been ranked sixth among top ten global cities on the billionaire count,[154] 48th on the Worldwide Centres of Commerce Index 2008,[155] seventh in the list of "Top Ten Cities for Billionaires" by Forbes magazine (April 2008),[156] and first in terms of those billionaires' average wealth.[157] As of 2008, the Globalization and World Cities Study Group (GaWC) has ranked Mumbai as an "Alpha world city", third in its categories of Global cities.[158] Mumbai is the third most expensive office market in the world, and was ranked among the fastest cities in the country for business startup in 2009.[159]

Civic administration


Municipal Corporation of Greater Mumbai (MCGM) Headquarters, the largest civic organisation in the country.

Mumbai, extending from Colaba in the south, to Mulund and Dahisar in the north, and Mankhurd in the east, is administered by the Municipal Corporation of Greater Mumbai (MCGM), formerly known as the Bombay Municipal Corporation (BMC).[117] The MCGM is in charge of the civic and infrastructure needs of the metropolis.[160] The Mayor is usually chosen through indirect election by the councillors from among themselves for a term of two and half years.

The Municipal Commissioner is the chief Executive Officer and head of the executive arm of the Municipal Corporation. All executive powers are vested in the Municipal Commissioner who is an Indian Administrative Service (IAS) officer appointed by the state government. Although the Municipal Corporation is the legislative body that lays down policies for the governance of the city, it is the Commissioner who is responsible for the execution of the policies. The Commissioner is appointed for a fixed term as defined by state statute. The powers of the Commissioner are those provided by statute and those delegated by the Corporation or the Standing Committee.[161]

The Municipal Corporation of Greater Mumbai was ranked 9th out of 21 Cities for best governance & administrative practices in India in 2014. It scored 3.5 on 10 compared to the national average of 3.3.[162]
A brown building with a central tower and sloping roofs surrounded by trees. A grassy ground and a coconut tree are in front of it.
The Bombay High Court exercises jurisdiction over Maharashtra, Goa, Daman and Diu, and Dadra and Nagar Haveli.

The two revenue districts of Mumbai come under the jurisdiction of a District Collector. The Collectors are in charge of property records and revenue collection for the Central Government, and oversee the national elections held in the city.

The Mumbai Police is headed by a Police Commissioner, who is an Indian Police Service (IPS) officer. The Mumbai Police comes under the state Home Ministry.[163] The city is divided into seven police zones and seventeen traffic police zones,[115] each headed by a Deputy Commissioner of Police.[164] The Traffic Police is a semi-autonomous body under the Mumbai Police. The Mumbai Fire Brigade department is headed by the Chief Fire Officer, who is assisted by four Deputy Chief Fire Officers and six Divisional Officers.[115]

Mumbai is the seat of the Bombay High Court, which exercises jurisdiction over the states of Maharashtra and Goa, and the Union Territories of Daman and Diu and Dadra and Nagar Haveli.[165] Mumbai also has two lower courts, the Small Causes Court for civil matters, and the Sessions Court for criminal cases. Mumbai also has a special Terrorist and Disruptive Activities (TADA) court for people accused of conspiring and abetting acts of terrorism in the city.[166]

Politics

Men in traditional Indian dresses posing for a photograph
First session of the Indian National Congress in Bombay (28–31 December 1885)

Mumbai had been a traditional stronghold and birthplace of the Indian National Congress, also known as the Congress Party.[167] The first session of the Indian National Congress was held in Bombay from 28–31 December 1885.[168] The city played host to the Indian National Congress six times during its first 50 years, and became a strong base for the Indian independence movement during the 20th century.[169]

The 1960s saw the rise of regionalist politics in Bombay, with the formation of the Shiv Sena on 19 June 1966, out of a feeling of resentment about the relative marginalisation of the native Marathi people in Bombay.[170] Shiv Sena switched from 'Marathi Cause' to larger 'Hindutva Cause' in 1985 and joined hands with Bhartiya Janata Party (BJP) in same year.[171] The Congress had dominated the politics of Bombay from independence until the early 1980s, when the Shiv Sena won the 1985 Bombay municipal corporation elections.[172]

In 1989, the Bharatiya Janata Party (BJP), a major national political party, forged an electoral alliance with the Shiv Sena to dislodge the Congress in the Maharashtra Legislative Assembly elections. In 1999, the Nationalist Congress Party (NCP) separated from the Congress, but later allied with the Congress, to form a joint venture known as the Democratic Front.[173] Currently, other parties such as Maharashtra Navnirman Sena (MNS), Samajwadi Party (SP), Bahujan Samaj Party (BSP), and several independent candidates also contest elections in the city.[174]

In the Indian national elections held every five years, Mumbai is represented by six parliamentary constituencies: North, North West, North East, North Central, South Central, and South.[175] A Member of Parliament (MP) to the Lok Sabha, the lower house of the Indian Parliament, is elected from each of the parliamentary constituencies. In the 2014 national elections, all six parliamentary constituencies were won by the BJP and Shiv Sena in alliance, both parties winning three seats each.[176]

In the Maharashtra state assembly elections held every five years, Mumbai is represented by 36 assembly constituencies.[177][178] A Member of the Legislative Assembly (MLA) to the Maharashtra Vidhan Sabha (Legislative Assembly) is elected from each of the assembly constituencies. In the 2014 state assembly elections, out of the 36 assembly constituencies, 15 were won by the BJP, 14 by the Shiv Sena and 5 by the Congress. Elections are also held every five years to elect corporators to power in the BMC.[179]

The Corporation comprises 227 directly elected Councillors representing the 24 municipal wards, five nominated Councillors having special knowledge or experience in municipal administration, and a Mayor whose role is mostly ceremonial.[180][181][182] In the 2007 municipal corporation elections, out of the 227 seats, the Shiv Sena-BJP alliance secured 111 seats, holding power in the BMC, while the Congress-NCP alliance bagged 85 seats.[183] The tenure of the Mayor, Deputy Mayor, and Municipal Commissioner is two and a half years.[184]

Transport

Mumbai Suburban Railway system carries more than 6.99 million commuters on a daily basis. It has the highest passenger densities of any urban railway system in the world.
The Mumbai Monorail opened in February 2014.
The first line of the Mumbai Metro opened in June 2014.
A BEST buses carry a total of 4.5 million passengers daily.
The black and yellow Premier Padmini Taxis are iconic of Mumbai.
The Bandra-Worli Sea Link is a cable-stayed bridge that connects central Mumbai with its western suburbs
Chhatrapati Shivaji International Airport is India's second-busiest airport in terms of passenger traffic.[185]
Jawaharlal Nehru Port Trust is the busiest port in India

Public transport

Public transport systems in Mumbai include the Mumbai Suburban Railway, Monorail, Metro, Brihanmumbai Electric Supply and Transport (BEST) buses, black-and-yellow meter taxis, auto rickshaws and ferries. Suburban railway and BEST bus services together accounted for about 88% of the passenger traffic in 2008.[186]

Rail

The Mumbai Suburban Railway, popularly known as Locals forms the backbone of the city's transport system.[187] It is operated by Central Railway and Western Railway.[188] Mumbai's suburban rail systems carried a total of 6.3 million passengers every day in 2007,[189] which is more than half of the Indian Railways daily carrying capacity. Trains are overcrowded during peak hours, with nine-car trains of rated capacity 1,700 passengers, actually carrying around 4,500 passengers at peak hours.[190] The Mumbai rail network is spread at an expanse of 319 route kilometres. 191 rakes (ratin-sets) of 9 car and 12 car composition are utilised to run a total of 2,226 train services in the city.[191]

The Mumbai Monorail and Mumbai Metro have been built and are being extended in phases to relieve overcrowding on the existing network. The Mumbai Monorail opened in early February 2014. The first line of the Mumbai Metro opened in early June 2014.

Mumbai is the headquarters of two of Indian Railways' zones: the Central Railway (CR) headquartered at Chhatrapati Shivaji Terminus (formerly Victoria Terminus), and the Western Railway (WR) headquartered at Churchgate.[192] Mumbai is also well connected to most parts of India by the Indian Railways. Long-distance trains originate from Chhatrapati Shivaji Terminus, Dadar, Lokmanya Tilak Terminus, Mumbai Central, Bandra Terminus, Andheri and Borivali.[193]

Bus

Mumbai's bus services carried over 5.5 million passengers per day in 2008.[186] Public buses run by BEST cover almost all parts of the metropolis, as well as parts of Navi Mumbai, Mira-Bhayandar and Thane.[194] The BEST operates a total of 4,608 buses[195] with CCTV Camera installed, ferrying 4.5 million passengers daily[186] over 390 routes. Its fleet consists of single-decker, double-decker, vestibule, low-floor, disabled-friendly, air-conditioned and Euro III compliant diesel and Compressed Natural Gas powered buses.[196] Maharashtra State Road Transport Corporation (MSRTC) buses provide intercity transport connecting Mumbai with other towns and cities of Maharashtra and nearby states.[197][198] The Navi Mumbai Municipal Transport (NMMT) also operates its Volvo buses in Mumbai, from Navi Mumbai to Bandra, Dindoshi and Borivali.[199]

Buses are generally favoured for commuting short to medium distances, while train fares are more economical for longer distance commutes.[200]

The Mumbai Darshan is a tourist bus service which explores numerous tourist attractions in Mumbai.[201] Mumbai BRTS (Bus Rapid Transit System) lanes have been planned throughout Mumbai.[202] Though 88% of the city's commuters travel by public transport, Mumbai still continues to struggle with traffic congestion.[203] Mumbai's transport system has been categorised as one of the most congested in the world.[204]

Road

Mumbai is served by National Highway 3, National Highway 4, National Highway 8, National Highway 17 and National Highway 222 of India's National Highways system.[205] The Mumbai-Pune Expressway was the first expressway built in India.[206] The Eastern Freeway was opened in 2013. The Mumbai Nashik Expressway, Mumbai-Vadodara Expressway,[207] is under construction. The Bandra-Worli Sea Link bridge, along with Mahim Causeway, links the island city to the western suburbs.[208] The three major road arteries of the city are the Eastern Express Highway from Sion to Thane, the Sion Panvel Expressway from Sion to Panvel and the Western Express Highway from Bandra to Borivali.[209] Mumbai has approximately 1,900 km (1,181 mi) of roads.[210]

Auto rickshaws are allowed to operate only in the suburban areas of Mumbai, while taxis are allowed to operate throughout Mumbai, but generally operate in South Mumbai.[211] Taxis and rickshaws in Mumbai are required by law to run on compressed natural gas (CNG),[212] and are a convenient, economical, and easily available means of transport.[211]

Mumbai had about 721,000 private vehicles as of March 2014,[213] 56,459 black and yellow taxis as of 2005,[214] and 106,000 auto rickshaws, as of May 2013.[215]

Air

The Chhatrapati Shivaji International Airport (formerly Sahar International Airport) is the main aviation hub in the city and the second busiest airport in India in terms of passenger traffic.[216] It handled 32.22 million passengers[217] and 648,742 tonnes of cargo[218] during FY 2013–14. An upgrade plan was initiated in 2006, targeted at increasing the capacity of the airport to handle up to 40 million passengers annually[219] and the new terminal T2 was opened in February 2014.[220]

The proposed Navi Mumbai International Airport to be built in the Kopra-Panvel area has been sanctioned by the Indian Government and will help relieve the increasing traffic burden on the existing airport.[221]

The Juhu Aerodrome was India's first airport, and now hosts a flying club and a heliport.[222]

Sea

Mumbai is served by two major ports, Mumbai Port Trust and Jawaharlal Nehru Port Trust, which lies just across the creek in Navi Mumbai.[223] Mumbai Port has one of the best natural harbours in the world, and has extensive wet and dry dock accommodation facilities.[224] Jawaharlal Nehru Port, commissioned on 26 May 1989, is the busiest and most modern major port in India.[225] It handles 55–60% of the country's total containerised cargo.[226] Ferries from Ferry Wharf in Mazagaon allow access to islands near the city.[227]

The city is also the headquarters of the Western Naval Command, and also an important base for the Indian Navy.[117]

Utility services

Under colonial rule, tanks were the only source of water in Mumbai. Many localities have been named after them. The BMC supplies potable water to the city from six lakes,[228][229] most of which comes from the Tulsi and Vihar lakes. The Tansa lake supplies water to the western suburbs and parts of the island city along the Western Railway.[230] The water is filtered at Bhandup,[230] which is Asia's largest water filtration plant.[231] India's first underground water tunnel is being built in Mumbai.[232]
About 700 million litres of water, out of a daily supply of 3500 million litres, is lost by way of water thefts, illegal connections and leakages, per day in Mumbai.[233] Almost all of Mumbai's daily refuse of 7,800 metric tonnes, of which 40 metric tonnes is plastic waste,[234] is transported to dumping grounds in Gorai in the northwest, Mulund in the northeast, and to the Deonar dumping ground in the east.[235] Sewage treatment is carried out at Worli and Bandra, and disposed of by two independent marine outfalls of 3.4 km (2.1 mi) and 3.7 km (2.3 mi) at Bandra and Worli respectively.[236]

Electricity is distributed by Brihanmumbai Electric Supply and Transport (BEST) in the island city, and by Reliance Energy, Tata Power, and Mahavitaran (Maharashtra State Electricity Distribution Co. Ltd) in the suburbs.[237] Consumption of electricity is growing faster than production capacity.[238] The largest telephone service provider is the state-owned MTNL, which held a monopoly over fixed line and cellular services up until 2000, and provides fixed line as well as mobile WLL services.[239]

Cell phone coverage is extensive, and the main service providers are Vodafone Essar, Airtel, MTNL, Loop Mobile, Reliance Communications, Idea Cellular and Tata Indicom. Both GSM and CDMA services are available in the city.[240] Many of the above service providers also provide broadband internet and wireless internet access in Mumbai. Mumbai has highest number of internet users in India with 16.4 [241]

Architecture

A brown building with clock towers, domes and pyramidal tops. Also a busiest railway station in India.[242] A wide street in front of it
The Chhatrapati Shivaji Terminus, formerly known as Victoria Terminus, is the headquarters of the Central Railway and a UNESCO World Heritage Site.

The architecture of the city is a blend of Gothic Revival, Indo-Saracenic, Art Deco, and other contemporary styles. Most of the buildings during the British period, such as the Victoria Terminus and Bombay University, were built in Gothic Revival style.[243] Their architectural features include a variety of European influences such as German gables, Dutch roofs, Swiss timbering, Romance arches, Tudor casements, and traditional Indian features.[244] There are also a few Indo-Saracenic styled buildings such as the Gateway of India.[245] Art Deco styled landmarks can be found along the Marine Drive and west of the Oval Maidan. Mumbai has the second largest number of Art Deco buildings in the world after Miami. In the newer suburbs, modern buildings dominate the landscape. Mumbai has by far the largest number of skyscrapers in India, with 956 existing buildings and 272 under construction as of 2009.

The Mumbai Heritage Conservation Committee (MHCC), established in 1995, formulates special regulations and by-laws to assist in the conservation of the city's heritage structures. Mumbai has two UNESCO World Heritage Sites, the Chhatrapati Shivaji Terminus and the Elephanta Caves.[246] In the south of Mumbai, there are colonial-era buildings and Soviet-style offices.[247] In the east are factories and some slums. On the West coast are former-textile mills being demolished and skyscrapers built on top. There are 31 buildings taller than 100m, compared with 200 in Shanghai, 500 in Hong Kong and 500 in New York.[247]

Demographics

According to the 2011 census, the population of Mumbai was 12,479,608. The population density is estimated to be about 20,482 persons per square kilometre. The living space is 4.5sq metre per person.[249] As Per 2011 census, Greater Mumbai, the area under the administration of the MCGM, has a literacy rate of 94.7%, higher than the national average of 86.7%. The number of slum-dwellers is estimated to be 9 million, up from 6 million in 2001,[250] that is, 62% of all Mumbaikers live in informal slums.
The sex ratio was 838 (females per 1,000 males) in the island city, 857 in the suburbs, and 848 as a whole in Greater Mumbai, all numbers lower than the national average of 914 females per 1,000 males. The low sex ratio is partly because of the large number of male migrants who come to the city to work.[251]

"Parsis of Bombay", a wood engraving, ca. 1878. Mumbai is home to the largest population of Parsis in the world.

Residents of Mumbai call themselves Mumbaikar, Mumbaiite or Bombayite. Mumbai has a large polyglot population like any other metropolitan city of India. Sixteen major languages of India are also spoken in Mumbai, most common being Marathi, Hindi, Gujarati and English.[252] English is extensively spoken and is the principal language of the city's white collar workforce. A colloquial form of Hindi, known as Bambaiya – a blend of Marathi, Hindi, Gujarati, Konkani, Urdu, Indian English and some invented words – is spoken on the streets.[253]

Mumbai suffers from the same major urbanisation problems seen in many fast growing cities in developing countries: widespread poverty and unemployment, poor public health and poor civic and educational standards for a large section of the population. With available land at a premium, Mumbai residents often reside in cramped, relatively expensive housing, usually far from workplaces, and therefore requiring long commutes on crowded mass transit, or clogged roadways. Many of them live in close proximity to bus or train stations although suburban residents spend significant time travelling southward to the main commercial district.[254] Dharavi, Asia's second largest slum (if Karachi's Orangi Town is counted as a single slum)[255] is located in central Mumbai and houses between 800,000 to one million people[256] in 2.39 square kilometres (0.92 sq mi), making it one of the most densely populated areas on Earth[257] with a population density of at least 334,728 persons per square kilometre. With a literacy rate of 69%, the slums in Mumbai are the most literate in India.[258]

The number of migrants to Mumbai from outside Maharashtra during the 1991–2001 decade was 1.12 million, which amounted to 54.8% of the net addition to the population of Mumbai.[259]

The number of households in Mumbai is forecast to rise from 4.2 million in 2008 to 6.6 million in 2020. The number of households with annual incomes of 2 million rupees will increase from 4% to 10% by 2020, amounting to 660,000 families. The number of households with incomes from 1–2 million rupees is also estimated to increase from 4% to 15% by 2020.[260]

Ethnic groups and religion

Others include Jains, Sikhs & Parsis
Religion in Mumbai[261]
Religion Percent
Hinduism
  
67.39%
Islam
  
18.56%
Buddhism
  
5.22%
Christianity
  
4.2%
Others
  
4.63%

The religions represented in Mumbai include Hindus (67.39%), Muslims (18.56%), Buddhists (5.22%), Jains (3.99%), Christians (4.2%),[262] Sikhs (0.58%), with Parsis and Jews making up the rest of the population.[263] The linguistic/ethnic demographics are: Maharashtrians (42%), Gujaratis (19%), with the rest hailing from other parts of India.[264]

Native Christians include East Indian Catholics, who were converted by the Portuguese during the 16th century,[265] while Goan and Mangalorean Catholics also constitute a significant portion of the Christian community of the city.[266] Jews settled in Bombay during the 18th century. The Bene Israeli Jewish community of Bombay, who migrated from the Konkan villages, south of Bombay, are believed to be the descendants of the Jews of Israel who were shipwrecked off the Konkan coast, probably in the year 175 BCE, during the reign of the Greek ruler, Antiochus IV Epiphanes.[267] Mumbai is also home to the largest population of Parsi Zoroastrians in the world, numbering about 80,000. Parsis migrated to India from Pars (Persia/Iran) following the Muslim conquest of Persia in the seventh century.[268] The oldest Muslim communities in Mumbai include the Dawoodi Bohras, Ismaili Khojas, and Konkani Muslims.[269]

Culture

A white building with a triangular façade and wide stairs
Asiatic Society of Bombay is one of the oldest public libraries in the city.

Mumbai's culture is a blend of traditional festivals, food, music and theatres. The city offers a cosmopolitan and diverse lifestyle with a variety of food, entertainment and night life, available in a form and abundance comparable to that in other world capitals. Mumbai's history as a major trading centre has led to a diverse range of cultures, religions and cuisines coexisting in the city. This unique blend of cultures is due to the migration of people from all over India since the British period.

Mumbai is the birthplace of Indian cinema[270]Dadasaheb Phalke laid the foundations with silent movies followed by Marathi talkies—and the oldest film broadcast took place in the early 20th century.[271] Mumbai also has a large number of cinema halls that feature Bollywood, Marathi and Hollywood movies. The Mumbai International Film Festival[272] and the award ceremony of the Filmfare Awards, the oldest and prominent film awards given for Hindi film industry in India, are held in Mumbai.[273] Despite most of the professional theatre groups that formed during the British Raj having disbanded by the 1950s, Mumbai has developed a thriving "theatre movement" tradition in Marathi, Hindi, English and other regional languages.[274][275]

Contemporary art is featured in both government-funded art spaces and private commercial galleries. The government-funded institutions include the Jehangir Art Gallery and the National Gallery of Modern Art. Built in 1833, the Asiatic Society of Bombay is one of the oldest public libraries in the city.[276] The Chhatrapati Shivaji Maharaj Vastu Sangrahalaya (formerly The Prince of Wales Museum) is a renowned museum in South Mumbai which houses rare ancient exhibits of Indian history.[277]

Mumbai has a zoo named Jijamata Udyaan (formerly Victoria Gardens), which also harbours a garden. The rich literary traditions of the city have been highlighted internationally by Booker Prize winners Salman Rushdie, Aravind Adiga. Marathi literature has been modernised in the works of Mumbai based authors such as Mohan Apte, Anant Kanekar, and Gangadhar Gadgil, and is promoted through an annual Sahitya Akademi Award, a literary honour bestowed by India's National Academy of Letters.[278]

Girgaum Chowpatty beach. Beaches are a popular tourist attraction in the city.

Mumbai residents celebrate both Western and Indian festivals. Diwali, Holi, Eid, Christmas, Navratri, Good Friday, Dussera, Moharram, Ganesh Chaturthi, Durga Puja and Maha Shivratri are some of the popular festivals in the city. The Kala Ghoda Arts Festival is an exhibition of a world of arts that encapsulates works of artists in the fields of music, dance, theatre, and films.[279] A week-long annual fair known as Bandra Fair, starting on the following Sunday after 8 September, is celebrated by people of all faiths, to commemorate the Nativity of Mary, mother of Jesus, on 8 September.[280]

The Banganga Festival is a two-day music festival, held annually in the month of January, which is organised by the Maharashtra Tourism Development Corporation (MTDC) at the historic Banganga Tank in Mumbai.[281] The Elephanta Festival—celebrated every February on the Elephanta Islands—is dedicated to classical Indian dance and music and attracts performers from across the country.[282] Public holidays specific to the city and the state include Maharashtra Day on 1 May, to celebrate the formation of Maharashtra state on 1 May 1960,[283][284] and Gudi Padwa which is the New Year's Day for Marathi people.

Beaches are a major tourist attraction in the city. The major beaches in Mumbai are Girgaum Chowpatty, Juhu Beach, Dadar Chowpatty, Gorai Beach, Marve Beach, Versova Beach, Madh Beach, Aksa Beach, and Manori Beach.[285] Most of the beaches are unfit for swimming, except Girgaum Chowpatty and Juhu Beach.[286] Essel World is a theme park and amusement centre situated close to Gorai Beach,[287] and includes Asia's largest theme water park, Water Kingdom.[288]

Media

The Times of India's first office is opposite the Chhatrapati Shivaji Terminus where it was founded.[289]

Mumbai has numerous newspaper publications, television and radio stations. Marathi dailies enjoy the maximum readership share in the city and the top Marathi language newspapers are Maharashtra Times, Navakaal, Lokmat, Loksatta, Mumbai Chaufer, Saamana and Sakaal.[290] Popular Marathi language magazines are Saptahik Sakaal, Grihashobhika, Lokrajya, Lokprabha & Chitralekha.[291] Popular English language newspapers published and sold in Mumbai include The Times of India, Mid-day, Hindustan Times, DNA India, and The Indian Express. Newspapers are also printed in other Indian languages.[292] Mumbai is home to Asia's oldest newspaper, Bombay Samachar, which has been published in Gujarati since 1822.[293] Bombay Durpan, the first Marathi newspaper, was started by Balshastri Jambhekar in Mumbai in 1832.

Numerous Indian and international television channels can be watched in Mumbai through one of the Pay TV companies or the local cable television provider. The metropolis is also the hub of many international media corporations, with many news channels and print publications having a major presence. The national television broadcaster, Doordarshan, provides two free terrestrial channels, while three main cable networks serve most households.[294]

The wide range of cable channels available includes Zee Marathi, Zee Talkies, ETV Marathi, Star Pravah, Mi Marathi, DD Sahyadri (All Marathi channels), news channels such as ABP Majha, IBN-Lokmat, Zee 24 Taas, sports channels like ESPN, Star Sports, National entertainment channels like Colors, Sony, Zee TV and Star Plus, business news channels like CNBC Awaaz, Zee Business, ET Now and Bloomberg UTV. News channels entirely dedicated to Mumbai include Sahara Samay Mumbai. Zing a popular Bollywood gossip channel is also based out of Mumbai.Satellite television (DTH) has yet to gain mass acceptance, due to high installation costs.[295] Prominent DTH entertainment services in Mumbai include Dish TV and Sky by Tata.[296]

There are twelve radio stations in Mumbai, with nine broadcasting on the FM band, and three All India Radio stations broadcasting on the AM band.[297] Mumbai also has access to Commercial radio providers such as WorldSpace, Sirius and XM. The Conditional Access System (CAS) started by the Union Government in 2006 met a poor response in Mumbai due to competition from its sister technology Direct-to-Home (DTH) transmission service.[298]

Bollywood, the Hindi film industry based in Mumbai, produces around 150–200 films every year.[299] The name Bollywood is a blend of Bombay and Hollywood.[300] The 2000s saw a growth in Bollywood's popularity overseas. This led filmmaking to new heights in terms of quality, cinematography and innovative story lines as well as technical advances such as special effects and animation.[301] Studios in Goregaon, including Film City, are the location for most movie sets.[302] The city also hosts the Marathi film industry which has seen increased popularity in recent years, and TV production companies.

Education

A clock tower amid trees and a playground
Schools in Mumbai are either "municipal schools" (run by the BMC) or private schools (run by trusts or individuals), which in some cases receive financial aid from the government.[303] The schools are affiliated either with the Maharashtra State Board (MSBSHSE), the All-India Council for the Indian School Certificate Examinations (CISCE), National Institute of Open Schooling (NIOS) or the Central Board for Secondary Education (CBSE) boards.[304] Marathi or English is the usual language of instruction.[305] The government run public schools lack many facilities, but are the only option for poorer residents who cannot afford the more expensive private schools.[306]

The primary education system of the BMC is the largest urban primary education system in Asia. The BMC operates 1,188 primary schools imparting primary education to 485,531 students in eight languages (Marathi, Hindi, Gujarati, Urdu, English, Tamil, Telugu, and Kannada). The BMC also imparts secondary education to 55,576 students through its 49 secondary schools.[307]

Under the 10+2+3/4 plan, students complete ten years of schooling and then enroll for two years in junior college, where they select one of three streams: arts, commerce, or science.[308] This is followed by either a general degree course in a chosen field of study, or a professional degree course, such as law, engineering and medicine.[309] Most colleges in the city are affiliated with the University of Mumbai, one of the largest universities in the world in terms of the number of graduates.[310]

The University Of Mumbai is one of the premier[311] universities in India. It was ranked 41 among the Top 50 Engineering Schools of the world by America's news broadcasting firm Business Insider in 2012 and was the only university in the list from the five emerging BRICS nations viz Brazil, Russia, India, China and South Africa.[312] Moreover, the University of Mumbai was ranked 5th in the list of best Universities in India by India Today in 2013[313] and ranked at 62 in the QS BRICS University rankings for 2013, a ranking of leading universities in the five BRICS countries (Brazil, Russia, India, China and South Africa).[314] Its strongest scores in the QS University Rankings: BRICS are for papers per faculty (8th), employer reputation (20th) and citations per paper (28th).[315] It was ranked 10th among the top Universities of India by QS in 2013.[315] With 7 of the top ten Indian Universities being purely science and technology universities, it was India's 3rd best Multi Disciplinary University in the QS University ranking.[315]

The Indian Institute of Technology (Bombay),[316] Veermata Jijabai Technological Institute (VJTI),[317] University Institute of Chemical Technology (UICT)[318] which are India's premier engineering and technology schools, and SNDT Women's University are the other autonomous universities in Mumbai.[319] Thadomal Shahani Engineering College is the first and the oldest private engineering college affiliated to the federal University of Mumbai and is also pioneered to be the first institute in the city's university to offer undergraduate level courses in Computer Engineering, Information Technology, Biomedical Engineering and Biotechnology.[320] Grant Medical College established in 1845 and Seth G.S. Medical College are the leading medical institutes affiliated with Sir Jamshedjee Jeejeebhoy Group of Hospitals and KEM Hospital respectively. Mumbai is also home to National Institute of Industrial Engineering (NITIE), Jamnalal Bajaj Institute of Management Studies (JBIMS), S P Jain Institute of Management and Research and several other management schools.[321] Government Law College and Sydenham College, respectively the oldest law and commerce colleges in India, are based in Mumbai.[322][323] The Sir J. J. School of Art is Mumbai's oldest art institution.[324]

Mumbai is home to two prominent research institutions: the Tata Institute of Fundamental Research (TIFR), and the Bhabha Atomic Research Centre (BARC).[325] The BARC operates CIRUS, a 40 MW nuclear research reactor at their facility in Trombay.[326]

Sports

A grassy ground with skyscrapers behind it
Brabourne Stadium, one of the oldest cricket stadiums in the country
Built in 1883, Mahalaxmi Racecourse was created out of a marshy land known as Mahalakshmi Flats.

Cricket is more popular than any other sport in the city. Due to a shortage of grounds, various modified versions (generally referred to as gully cricket) are played everywhere. Mumbai is also home to the Board of Control for Cricket in India (BCCI)[327] and Indian Premier League (IPL).[328] The Mumbai cricket team represents the city in the Ranji Trophy and has won 40 titles, the most by any team.[329] The city is also represented by the Mumbai Indians in the Indian Premier League. The city has two international cricket grounds, the Wankhede Stadium and the Brabourne Stadium. The first cricket test match in India was played in Mumbai at Bombay Gymkhana.[330] The biggest cricketing event to be staged in the city so far is the final of the 2011 ICC Cricket World Cup which was played at the Wankhede Stadium. Mumbai and London are the only two cities to have hosted both a World Cup final and the final of an ICC Champions Trophy which was played at the Brabourne Stadium in 2006.[331]

Football is another popular sport in the city, with the FIFA World Cup and the English Premier League being followed widely.[332] In Indian Super League, Mumbai City FC represented the city; while in the I-League (matches in the city are played at the Cooperage Ground), the city is represented by two teams: Mumbai FC[333] and Air-India.[334] When the Elite Football League of India was introduced in August 2011, Mumbai was noted as one of eight cities to be awarded a team for the inaugural season. Named the Mumbai Gladiators, the team's first season will be played in Pune in late 2012,[335] and it will be Mumbai's first professional American football franchise.[336] In Hockey, Mumbai is home to the Mumbai Marines and Mumbai Magicians in the World Series Hockey and Hockey India League respectively .

Every February, Mumbai holds derby races at the Mahalaxmi Racecourse. Mcdowell's Derby is also held in February at the Turf Club in Mumbai.[337] In March 2004, the Mumbai Grand Prix was part of the F1 powerboat world championship.[338] and the Force India F1 team car was unveiled in the city, in 2008.[339] The city is planning to build its own F1 track and various sites in the city were being chalked out, of which the authorities have planned to zero down on Marve-Malad or Panvel-Kalyan land. If approved, the track will be clubbed with a theme park and will spread over an area of some 160 to 200 ha (400 to 500 acres).[340] In 2004, the annual Mumbai Marathon was established as a part of "The Greatest Race on Earth". Mumbai has also played host to the Kingfisher Airlines Tennis Open, an International Series tournament of the ATP World Tour, in 2006 and 2007.[341]

Nanobiomechanics


From Wikipedia, the free encyclopedia

Nanobiomechanics (also bionanomechanics) is an emerging field in nanoscience and biomechanics that combines the powerful tools of nanomechanics to explore fundamental science of biomaterials and biomechanics.

Since the introduction by its founder Yuan-Cheng Fung, the field of biomechanics has become one of the branches of mechanics and bioscience. For many years, biomechanics has examined tissue. Through advancements in nanoscience, the scale of the forces that could be measured and also the scale of observation of biomaterials was reduced to "nano" and "pico" level. Consequently it became possible to measure the mechanical properties of biological materials at nanoscale.

Most of the biological materials have different hierarchical levels, and the smallest ones refer to the nanoscale. For example bone has up to seven levels of biological organization, and the smallest level, i.e., single collagen fibril and hydroxylapatite minerals have dimensions well below 100 nm. Therefore, being able to probe properties at this small scales provides a great opportunity for better understanding the fundamental properties of these materials. For example, measurements have shown that nanomechanical heterogeneity exists even within single collagen fibrils as small as 100 nm.[1]

One of the other most relevant topics in this field is measurement of tiny forces on living cells to recognize changes caused by different diseases. For example, it has been shown that red blood cells infected by malaria are 10 times stiffer than normal cells.[2] Likewise, it has been shown that cancer cells are 70 percent softer than normal cells.[3] Early signs of aging cartilage and osteoarthritis has been shown by looking at the changes in the tissue at the nanoscale.[4]

Methods and Instrumentation

The common methods in nanobiomechanics are summarized below:

Examples of relevant materials


High resolution AFM image of cortical bone and single collagen fibril (inset)

Computational nanobiomechanics

In addition to experimental aspect, research has been expanding through computational methods. Molecular dynamics (MD) simulations have provided a wealth of knowledge in this area. Although, the MD simulation are still limited to a small number of atoms and molecules, due to limitation in the computational performance, they have proved to be an instrumental branch of this emerging field.

Nanobiotechnology

From Wikipedia, the free encyclopedia

Nanobiotechnology, bionanotechnology, and nanobiology are terms that refer to the intersection of nanotechnology and biology. Given that the subject is one that has only emerged very recently, bionanotechnology and nanobiotechnology serve as blanket terms for various related technologies.

This discipline helps to indicate the merger of biological research with various fields of nanotechnology. Concepts that are enhanced through nanobiology include: nanodevices, nanoparticles, and nanoscale phenomena that occurs within the discipline of nanotechnology. This technical approach to biology allows scientists to imagine and create systems that can be used for biological research. Biologically inspired nanotechnology uses biological systems as the inspirations for technologies not yet created. However, as with nanotechnology and biotechnology, bionanotechnology does have many potential ethical issues associated with it.

The most important objectives that are frequently found in nanobiology involve applying nanotools to relevant medical/biological problems and refining these applications. Developing new tools, such as peptoid nanosheets, for medical and biological purposes is another primary objective in nanotechnology. New nanotools are often made by refining the applications of the nanotools that are already being used. The imaging of native biomolecules, biological membranes, and tissues is also a major topic for the nanobiology researchers. Other topics concerning nanobiology include the use of cantilever array sensors and the application of nanophotonics for manipulating molecular processes in living cells.

Recently, the use of microorganisms to synthesize functional nanoparticles has been of great interest. Microorganisms can change the oxidation state of metals. These microbial processes have opened up new opportunities for us to explore novel applications, for example, the biosynthesis of metal nanomaterials. In contrast to chemical and physical methods, microbial processes for synthesizing nanomaterials can be achieved in aqueous phase under gentle and environmentally benign conditions. This approach has become an attractive focus in current green bionanotechnology research towards sustainable development.

Terminology

The terms are often used interchangeably. When a distinction is intended, though, it is based on whether the focus is on applying biological ideas or on studying biology with nanotechnology. Bionanotechnology generally refers to the study of how the goals of nanotechnology can be guided by studying how biological "machines" work and adapting these biological motifs into improving existing nanotechnologies or creating new ones Nanobiotechnology, on the other hand, refers to the ways that nanotechnology is used to create devices to study biological systems.

In other words, nanobiotechnology is essentially miniaturized biotechnology, whereas bionanotechnology is a specific application of nanotechnology. For example, DNA nanotechnology or cellular engineering would be classified as bionanotechnology because they involve working with biomolecules on the nanoscale. Conversely, many new medical technologies involving nanoparticles as delivery systems or as sensors would be examples of nanobiotechnology since they involve using nanotechnology to advance the goals of biology.

The definitions enumerated above will be utilized whenever a distinction between nanobio and bionano is made in this article. However, given the overlapping usage of the terms in modern parlance, individual technologies may need to be evaluated to determine which term is more fitting. As such, they are best discussed in parallel.

Concepts

Most of the scientific concepts in bionanotechnology are derived from other fields. Biochemical principles that are used to understand the material properties of biological systems are central in bionanotechnology because those same principles are to be used to create new technologies. Material properties and applications studied in bionanoscience include mechanical properties(e.g. deformation, adhesion, failure), electrical/electronic (e.g. electromechanical stimulation, capacitors, energy storage/batteries), optical (e.g. absorption, luminescence, photochemistry), thermal (e.g. thermomutability, thermal management), biological (e.g. how cells interact with nanomaterials, molecular flaws/defects, biosensing, biological mechanisms s.a. mechanosensing), nanoscience of disease (e.g. genetic disease, cancer, organ/tissue failure), as well as computing (e.g. DNA computing). The impact of bionanoscience, achieved through structural and mechanistic analyses of biological processes at nanoscale, is their translation into synthetic and technological applications through nanotechnology.

Nano-biotechnology takes most of its fundamentals from nanotechnology. Most of the devices designed for nano-biotechnological use are directly based on other existing nanotechnologies. Nano-biotechnology is often used to describe the overlapping multidisciplinary activities associated with biosensors, particularly where photonics, chemistry, biology, biophysics, nano-medicine, and engineering converge. Measurement in biology using wave guide techniques, such as dual polarization interferometry, are another example.

Applications

Applications of bionanotechnology are extremely widespread. Insofar as the distinction holds, nanobiotechnology is much more commonplace in that it simply provides more tools for the study of biology. Bionanotechnology, on the other hand, promises to recreate biological mechanisms and pathways in a form that is useful in other ways.

Nanobiotechnology

Nanobiotechnology (sometimes referred to as nanobiology) is best described as helping modern medicine progress from treating symptoms to generating cures and regenerating biological tissues. Three American patients have received whole cultured bladders with the help of doctors who use nanobiology techniques in their practice. Also, it has been demonstrated in animal studies that a uterus can be grown outside the body and then placed in the body in order to produce a baby. Stem cell treatments have been used to fix diseases that are found in the human heart and are in clinical trials in the United States. There is also funding for research into allowing people to have new limbs without having to resort to prosthesis. Artificial proteins might also become available to manufacture without the need for harsh chemicals and expensive machines. It has even been surmised that by the year 2055, computers may be made out of biochemicals and organic salts.

Another example of current nanobiotechnological research involves nanospheres coated with fluorescent polymers. Researchers are seeking to design polymers whose fluorescence is quenched when they encounter specific molecules. Different polymers would detect different metabolites. The polymer-coated spheres could become part of new biological assays, and the technology might someday lead to particles which could be introduced into the human body to track down metabolites associated with tumors and other health problems. Another example, from a different perspective, would be evaluation and therapy at the nanoscopic level, i.e. the treatment of Nanobacteria (25-200 nm sized) as is done by NanoBiotech Pharma.

While nanobiology is in its infancy, there are a lot of promising methods that will rely on nanobiology in the future. Biological systems are inherently nano in scale; nanoscience must merge with biology in order to deliver biomacromolecules and molecular machines that are similar to nature. Controlling and mimicking the devices and processes that are constructed from molecules is a tremendous challenge to face the converging disciplines of nanotechnology. All living things, including humans, can be considered to be nanofoundries. Natural evolution has optimized the "natural" form of nanobiology over millions of years. In the 21st century, humans have developed the technology to artificially tap into nanobiology. This process is best described as "organic merging with synthetic." Colonies of live neurons can live together on a biochip device; according to research from Dr. Gunther Gross at the University of North Texas. Self-assembling nanotubes have the ability to be used as a structural system. They would be composed together with rhodopsins; which would facilitate the optical computing process and help with the storage of biological materials. DNA (as the software for all living things) can be used as a structural proteomic system - a logical component for molecular computing. Ned Seeman - a researcher at New York University - along with other researchers are currently researching concepts that are similar to each other.

Bionanotechnology

DNA nanotechnology is one important example of bionanotechnology. The utilization of the inherent properties of nucleic acids like DNA to create useful materials is a promising area of modern research. Another important area of research involves taking advantage of membrane properties to generate synthetic membranes. Proteins that self-assemble to generate functional materials could be used as a novel approach for the large-scale production of programmable nanomaterials. One example is the development of amyloids found in bacterial biofilms as engineered nanomaterials that can be programmed genetically to have different properties. Protein folding studies provide a third important avenue of research, but one that has been largely inhibited by our inability to predict protein folding with a sufficiently high degree of accuracy. Given the myriad uses that biological systems have for proteins, though, research into understanding protein folding is of high importance and could prove fruitful for bionanotechnology in the future.

Lipid nanotechnology is another major area of research in bionanotechnology, where physico-chemical properties of lipids such as their antifouling and self-assembly is exploited to build nanodevices with applications in medicine and engineering.

Tools

This field relies on a variety of research methods, including experimental tools (e.g. imaging, characterization via AFM/optical tweezers etc.), x-ray diffraction based tools, synthesis via self-assembly, characterization of self-assembly (using e.g. dual polarization interferometry, recombinant DNA methods, etc.), theory (e.g. statistical mechanics, nanomechanics, etc.), as well as computational approaches (bottom-up multi-scale simulation, supercomputing).

Nanomedicine


From Wikipedia, the free encyclopedia

Nanomedicine is the medical application of nanotechnology.[1] Nanomedicine ranges from the medical applications of nanomaterials, to nanoelectronic biosensors, and even possible future applications of molecular nanotechnology. Current problems for nanomedicine involve understanding the issues related to toxicity and environmental impact of nanoscale materials (materials whose structure is on the scale of nanometers, i.e. billionths of a meter).

Functionalities can be added to nanomaterials by interfacing them with biological molecules or structures. The size of nanomaterials is similar to that of most biological molecules and structures; therefore, nanomaterials can be useful for both in vivo and in vitro biomedical research and applications. Thus far, the integration of nanomaterials with biology has led to the development of diagnostic devices, contrast agents, analytical tools, physical therapy applications, and drug delivery vehicles.

Nanomedicine seeks to deliver a valuable set of research tools and clinically useful devices in the near future.[2][3] The National Nanotechnology Initiative expects new commercial applications in the pharmaceutical industry that may include advanced drug delivery systems, new therapies, and in vivo imaging.[4] Nanomedicine research is receiving funding from the US National Institutes of Health, including the funding in 2005 of a five-year plan to set up four nanomedicine centers.

Nanomedicine is a large industry, with nanomedicine sales reaching $6.8 billion in 2004, and with over 200 companies and 38 products worldwide, a minimum of $3.8 billion in nanotechnology R&D is being invested every year.[5] In April 2006, the journal Nature Materials estimated that 130 nanotech-based drugs and delivery systems were being developed worldwide.[6] As the nanomedicine industry continues to grow, it is expected to have a significant impact on the economy.

Drug delivery

Nanoparticles (top), liposomes (middle), and dendrimers (bottom) are some nanomaterials being investigated for use in nanomedicine.

Nanotechnology has provided the possibility of delivering drugs to specific cells using nanoparticles.

The overall drug consumption and side-effects may be lowered significantly by depositing the active agent in the morbid region only and in no higher dose than needed. Targeted drug delivery is intended to reduce the side effects of drugs with concomitant decreases in consumption and treatment expenses. Drug delivery focuses on maximizing bioavailability both at specific places in the body and over a period of time. This can potentially be achieved by molecular targeting by nanoengineered devices.[7][8] More than $65 billion are wasted each year due to poor bioavailability.[citation needed] A benefit of using nanoscale for medical technologies is that smaller devices are less invasive and can possibly be implanted inside the body, plus biochemical reaction times are much shorter. These devices are faster and more sensitive than typical drug delivery.[9] The efficacy of drug delivery through nanomedicine is largely based upon: a) efficient encapsulation of the drugs, b) successful delivery of drug to the targeted region of the body, and c) successful release of the drug.[citation needed]

Drug delivery systems, lipid- [10] or polymer-based nanoparticles,[11] can be designed to improve the pharmacokinetics and biodistribution of the drug.[12][13][14] However, the pharmacokinetics and pharmacodynamics of nanomedicine is highly variable among different patients.[15] When designed to avoid the body's defence mechanisms,[16] nanoparticles have beneficial properties that can be used to improve drug delivery. Complex drug delivery mechanisms are being developed, including the ability to get drugs through cell membranes and into cell cytoplasm. Triggered response is one way for drug molecules to be used more efficiently. Drugs are placed in the body and only activate on encountering a particular signal. For example, a drug with poor solubility will be replaced by a drug delivery system where both hydrophilic and hydrophobic environments exist, improving the solubility.[17] Drug delivery systems may also be able to prevent tissue damage through regulated drug release; reduce drug clearance rates; or lower the volume of distribution and reduce the effect on non-target tissue. However, the biodistribution of these nanoparticles is still imperfect due to the complex host's reactions to nano- and microsized materials[16] and the difficulty in targeting specific organs in the body. Nevertheless, a lot of work is still ongoing to optimize and better understand the potential and limitations of nanoparticulate systems. While advancement of research proves that targeting and distribution can be augmented by nanoparticles, the dangers of nanotoxicity become an important next step in further understanding of their medical uses.[18]

Nanoparticles can be used in combination therapy for decreasing antibiotic resistance or for their antimicrobial properties.[19][20][21] Nanoparticles might also used to circumvent multidrug resistance (MDR) mechanisms.[22]

Types of systems used

Two forms of nanomedicine that have already been tested in mice and are awaiting human trials that will be using gold nanoshells to help diagnose and treat cancer,[23] and using liposomes as vaccine adjuvants and as vehicles for drug transport.[24][25] Similarly, drug detoxification is also another application for nanomedicine which has shown promising results in rats.[26] Advances in Lipid nanotechnology was also instrumental in engineering medical nanodevices and novel drug delivery systems as well as in developing sensing applications.[27] Another example can be found in dendrimers and nanoporous materials. Another example is to use block co-polymers, which form micelles for drug encapsulation.[11]

Polymeric nano-particles are a competing technology to lipidic (based mainly on Phospholipids) nano-particles. There is an additional risk of toxicity associated with polymers not widely studied or understood. The major advantages of polymers is stability, lower cost and predictable characterisation. However, in the patient's body this very stability (slow degradation) is a negative factor. Phospholipids on the other hand are membrane lipids (already present in the body and surrounding each cell), have a GRAS (Generally Recognised As Safe) status from FDA and are derived from natural sources without any complex chemistry involved. They are not metabolised but rather absorbed by the body and the degradation products are themselves nutrients (fats or micronutrients).

Protein and peptides exert multiple biological actions in the human body and they have been identified as showing great promise for treatment of various diseases and disorders. These macromolecules are called biopharmaceuticals. Targeted and/or controlled delivery of these biopharmaceuticals using nanomaterials like nanoparticles and Dendrimers is an emerging field called nanobiopharmaceutics, and these products are called nanobiopharmaceuticals.

Another vision is based on small electromechanical systems; nanoelectromechanical systems are being investigated for the active release of drugs. Some potentially important applications include cancer treatment with iron nanoparticles or gold shells.Nanotechnology is also opening up new opportunities in implantable delivery systems, which are often preferable to the use of injectable drugs, because the latter frequently display first-order kinetics (the blood concentration goes up rapidly, but drops exponentially over time). This rapid rise may cause difficulties with toxicity, and drug efficacy can diminish as the drug concentration falls below the targeted range.[citation needed]

Applications

Some nanotechnology-based drugs that are commercially available or in human clinical trials include:
  • Abraxane, approved by the U.S. Food and Drug Administration (FDA) to treat breast cancer,[28] non-small- cell lung cancer (NSCLC)[29] and pancreatic cancer,[30] is the nanoparticle albumin bound paclitaxel.
  • Doxil was originally approved by the FDA for the use on HIV-related Kaposi's sarcoma. It is now being used to also treat ovarian cancer and multiple myeloma. The drug is encased in liposomes, which helps to extend the life of the drug that is being distributed. Liposomes are self-assembling, spherical, closed colloidal structures that are composed of lipid bilayers that surround an aqueous space. The liposomes also help to increase the functionality and it helps to decrease the damage that the drug does to the heart muscles specifically.[31]
  • C-dots (Cornell dots) are the smallest silica-based nanoparticles with the size <10 nm. The particles are infused with organic dye which will light up with fluorescence. Clinical trial is underway since 2011 to use the C-dots as diagnostic tool to assist surgeons to identify the location of tumor cells.[32]
  • An early phase clinical trial using the platform of ‘Minicell’ nanoparticle for drug delivery have been tested on patients with advanced and untreatable cancer. Built from the membranes of mutant bacteria, the minicells were loaded with paclitaxel and coated with cetuximab, antibodies that bind the epidermal growth factor receptor (EGFR) which is often overexpressed in a number of cancers, as a 'homing' device to the tumor cells. The tumor cells recognize the bacteria from which the minicells have been derived, regard it as invading microorganism and engulf it. Once inside, the payload of anti-cancer drug kills the tumor cells. Measured at 400 nanometers, the minicell is bigger than synthetic particles developed for drug delivery. The researchers indicated that this larger size gives the minicells a better profile in side-effects because the minicells will preferentially leak out of the porous blood vessels around the tumor cells and do not reach the liver, digestive system and skin. This Phase 1 clinical trial demonstrated that this treatment is well tolerated by the patients. As a platform technology, the minicell drug delivery system can be used to treat a number of different cancers with different anti-cancer drugs with the benefit of lower dose and less side-effects.[33][34]

Cancer


A schematic illustration showing how nanoparticles or other cancer drugs might be used to treat cancer.

Another nanoproperty, high surface area to volume ratio, allows many functional groups to be attached to a nanoparticle, which can seek out and bind to certain tumor cells. Additionally, the small size of nanoparticles (10 to 100 nanometers), allows them to preferentially accumulate at tumor sites (because tumors lack an effective lymphatic drainage system).[35] Limitations to conventional cancer chemotherapy include drug resistance, lack of selectivity, and lack of solubility. Nanoparticles have the potential to overcome these problems.[36]

In photodynamic therapy, a particle is placed within the body and is illuminated with light from the outside. The light gets absorbed by the particle and if the particle is metal, energy from the light will heat the particle and surrounding tissue. Light may also be used to produce high energy oxygen molecules which will chemically react with and destroy most organic molecules that are next to them (like tumors). This therapy is appealing for many reasons. It does not leave a "toxic trail" of reactive molecules throughout the body (chemotherapy) because it is directed where only the light is shined and the particles exist. Photodynamic therapy has potential for a noninvasive procedure for dealing with diseases, growth and tumors. Kanzius RF therapy is one example of such therapy.[citation needed] Also, gold nanoparticles have the potential to join numerous therapeutic functions into a single platform, by targeting specific tumor cells, tissues and organs.[37][38]

Visualization

In vivo imaging is another area where tools and devices are being developed. Using nanoparticle contrast agents, images such as ultrasound and MRI have a favorable distribution and improved contrast. This might be accomplished by self assembled biocompatible nanodevices that will detect, evaluate, treat and report to the clinical doctor automatically.

The small size of nanoparticles endows them with properties that can be very useful in oncology, particularly in imaging. Quantum dots (nanoparticles with quantum confinement properties, such as size-tunable light emission), when used in conjunction with MRI (magnetic resonance imaging), can produce exceptional images of tumor sites. Nanoparticles of cadmium selenide (quantum dots) glow when exposed to ultraviolet light. When injected, they seep into cancer tumors. The surgeon can see the glowing tumor, and use it as a guide for more accurate tumor removal.These nanoparticles are much brighter than organic dyes and only need one light source for excitation. This means that the use of fluorescent quantum dots could produce a higher contrast image and at a lower cost than today's organic dyes used as contrast media. The downside, however, is that quantum dots are usually made of quite toxic elements.[citation needed]

Tracking movement can help determine how well drugs are being distributed or how substances are metabolized. It is difficult to track a small group of cells throughout the body, so scientists used to dye the cells. These dyes needed to be excited by light of a certain wavelength in order for them to light up. While different color dyes absorb different frequencies of light, there was a need for as many light sources as cells. A way around this problem is with luminescent tags. These tags are quantum dots attached to proteins that penetrate cell membranes. The dots can be random in size, can be made of bio-inert material, and they demonstrate the nanoscale property that color is size-dependent. As a result, sizes are selected so that the frequency of light used to make a group of quantum dots fluoresce is an even multiple of the frequency required to make another group incandesce. Then both groups can be lit with a single light source. They have also found a way to insert nanoparticles[39] into the affected parts of the body so that those parts of the body will glow showing the tumor growth or shrinkage or also organ trouble.[40]

Sensing

Nanotechnology-on-a-chip is one more dimension of lab-on-a-chip technology. Magnetic nanoparticles, bound to a suitable antibody, are used to label specific molecules, structures or microorganisms. Gold nanoparticles tagged with short segments of DNA can be used for detection of genetic sequence in a sample. Multicolor optical coding for biological assays has been achieved by embedding different-sized quantum dots into polymeric microbeads. Nanopore technology for analysis of nucleic acids converts strings of nucleotides directly into electronic signatures.[citation needed]
Sensor test chips containing thousands of nanowires, able to detect proteins and other biomarkers left behind by cancer cells, could enable the detection and diagnosis of cancer in the early stages from a few drops of a patient's blood.[41]Nanotechnology is helping to advance the use of arthroscopes, which are pencil-sized devices that are used in surgeries with lights and cameras so surgeons can do the surgeries with smaller incisions. The smaller the incisions the faster the healing time which is better for the patients. It is also helping to find a way to make an arthroscope smaller than a strand of hair.[42]

Tissue engineering

Nanotechnology may be used as part of tissue engineering to help reproduce or repair damaged tissue using suitable nanomaterial-based scaffolds and growth factors. Tissue engineering if successful may replace conventional treatments like organ transplants or artificial implants. Nanoparticles such as graphene, carbon nanotubes, molybdenum disulfide and tungsten disulfide are being used as reinforcing agents to fabricate mechanically strong biodegradable polymeric nanocomposites for bone tissue engineering applications. The addition of these nanoparticles in the polymer matrix at low concentrations (~0.2 weight %) leads to significant improvements in the compressive and flexural mechanical properties of polymeric nanocomposites.[43][44] Potentially, these nanocomposites may be used as a novel, mechanically strong, light weight composite as bone implants.

For example, a flesh welder was demonstrated to fuse two pieces of chicken meat into a single piece using a suspension of gold-coated nanoshells activated by an infrared laser. This could be used to weld arteries during surgery.[45] Another example is nanonephrology, the use of nanomedicine on the kidney.

Medical devices

Neuro-electronic interfacing is a visionary goal dealing with the construction of nanodevices that will permit computers to be joined and linked to the nervous system. This idea requires the building of a molecular structure that will permit control and detection of nerve impulses by an external computer. A refuelable strategy implies energy is refilled continuously or periodically with external sonic, chemical, tethered, magnetic, or biological electrical sources, while a nonrefuelable strategy implies that all power is drawn from internal energy storage which would stop when all energy is drained. A nanoscale enzymatic biofuel cell for self-powered nanodevices have been developed that uses glucose from biofluids including human blood and watermelons.[46] One limitation to this innovation is the fact that electrical interference or leakage or overheating from power consumption is possible. The wiring of the structure is extremely difficult because they must be positioned precisely in the nervous system. The structures that will provide the interface must also be compatible with the body's immune system.[47]

Molecular nanotechnology is a speculative subfield of nanotechnology regarding the possibility of engineering molecular assemblers, machines which could re-order matter at a molecular or atomic scale. Nanomedicine would make use of these nanorobots, introduced into the body, to repair or detect damages and infections. Molecular nanotechnology is highly theoretical, seeking to anticipate what inventions nanotechnology might yield and to propose an agenda for future inquiry. The proposed elements of molecular nanotechnology, such as molecular assemblers and nanorobots are far beyond current capabilities.[1][47][48][49]

1947–1948 civil war in Mandatory Palestine

From Wikipedia, the free encyclopedia During the civil war, the Jewish and Arab communities of Palestine clashed (the latter supported b...