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Wednesday, February 4, 2015

Chirality (chemistry)


From Wikipedia, the free encyclopedia


Two enantiomers of a generic amino acid that is chiral

(S)-Alanine (left) and (R)-alanine (right) in zwitterionic form at neutral pH

A molecule is considered chiral /ˈkaɪərəl/ if there exists another molecule that is of identical composition, but which is arranged in a non-superposable mirror image. The presence of an asymmetric carbon atom is often the feature that causes chirality in molecules.[1][2][3][4]

Human hands are perhaps the most universally recognized example of chirality: the left hand is a non-superposable mirror image of the right hand; no matter how the two hands are oriented, it is impossible for all the major features of both hands to coincide. The term chirality is derived from the Greek word for hand, χειρ (kheir). It is a mathematical approach to the concept of "handedness".

Conversely, an achiral object, such as an atom, is symmetric; its mirror image is not truly opposite, but rather is indistinguishable from the original.

In chemistry, chirality usually refers to molecules. Two mirror images of a chiral molecule are called enantiomers or optical isomers. Pairs of enantiomers are often designated as "right-" and "left-handed".

Molecular chirality is of interest because of its application to stereochemistry in inorganic chemistry, organic chemistry, physical chemistry, biochemistry, and supramolecular chemistry.

History

The term optical activity is derived from the interaction of chiral materials with polarized light. In a solution, the (−)-form, or levorotary form, of an optical isomer rotates the plane of a beam of polarized light counterclockwise. The (+)-form, or dextrorotatory form, of an optical isomer does the opposite. The property was first observed by Jean-Baptiste Biot in 1815,[5] and gained considerable importance in the sugar industry, analytical chemistry, and pharmaceuticals. Louis Pasteur deduced in 1848 that this phenomenon has a molecular basis.[6] Artificial composite materials displaying the analog of optical activity but in the microwave region were introduced by J.C. Bose in 1898,[7] and gained considerable attention from the mid-1980s.[8] The term chirality itself was coined by Lord Kelvin in 1894.[9] Different enantiomers or diastereomers of a compound were formerly called optical isomers due to their different optical properties.[10]

Symmetry

The symmetry of a molecule (or any other object) determines whether it is chiral. A molecule is achiral (not chiral) when an improper rotation, that is a combination of a rotation and a reflection in a plane, perpendicular to the axis of rotation, results in the same molecule - see chirality (mathematics). For tetrahedral molecules, the molecule is chiral if all four substituents are different.

A chiral molecule is not necessarily asymmetric (devoid of any symmetry element), as it can have, for example, rotational symmetry.

Naming conventions

By configuration: R- and S-

For chemists, the R / S system is the most important nomenclature system for denoting enantiomers, which does not involve a reference molecule such as glyceraldehyde. It labels each chiral center R or S according to a system by which its substituents are each assigned a priority, according to the Cahn–Ingold–Prelog priority rules (CIP), based on atomic number. If the center is oriented so that the lowest-priority of the four is pointed away from a viewer, the viewer will then see two possibilities: If the priority of the remaining three substituents decreases in clockwise direction, it is labeled R (for Rectus, Latin for straight), if it decreases in counterclockwise direction, it is S (for Sinister, Latin for left).[11]

This system labels each chiral center in a molecule (and also has an extension to chiral molecules not involving chiral centers). Thus, it has greater generality than the D/L system, and can label, for example, an (R,R) isomer versus an (R,S) — diastereomers.

The R / S system has no fixed relation to the (+)/(−) system. An R isomer can be either dextrorotatory or levorotatory, depending on its exact substituents.

The R / S system also has no fixed relation to the D/L system. For example, the side-chain one of serine contains a hydroxyl group, -OH. If a thiol group, -SH, were swapped in for it, the D/L labeling would, by its definition, not be affected by the substitution. But this substitution would invert the molecule's R / S labeling, because the CIP priority of CH2OH is lower than that for CO2H but the CIP priority of CH2SH is higher than that for CO2H.

For this reason, the D/L system remains in common use in certain areas of biochemistry, such as amino acid and carbohydrate chemistry, because it is convenient to have the same chiral label for all of the commonly occurring structures of a given type of structure in higher organisms. In the D/L system, they are nearly all consistent - naturally occurring amino acids are all L, while naturally occurring carbohydrates are nearly all D. In the R / S system, they are mostly S, but there are some common exceptions.

By optical activity: (+)- and (−)- or d- and l-

An enantiomer can be named by the direction in which it rotates the plane of polarized light. If it rotates the light clockwise (as seen by a viewer towards whom the light is traveling), that enantiomer is labeled (+). Its mirror-image is labeled (−). The (+) and (−) isomers have also been termed d- and l-, respectively (for dextrorotatory and levorotatory). Naming with d- and l- is easy to confuse with D- and L- labeling and is therefore strongly discouraged by IUPAC.[12]

By configuration: D- and L-

An optical isomer can be named by the spatial configuration of its atoms. The D/L system (named after Latin dexter and laevus, right and left), not to be confused with the d- and l-system, see above, does this by relating the molecule to glyceraldehyde. Glyceraldehyde is chiral itself, and its two isomers are labeled D and L (typically typeset in small caps in published work). Certain chemical manipulations can be performed on glyceraldehyde without affecting its configuration, and its historical use for this purpose (possibly combined with its convenience as one of the smallest commonly used chiral molecules) has resulted in its use for nomenclature. In this system, compounds are named by analogy to glyceraldehyde, which, in general, produces unambiguous designations, but is easiest to see in the small biomolecules similar to glyceraldehyde. One example is the chiral amino acid alanine, which has two optical isomers, and they are labeled according to which isomer of glyceraldehyde they come from. On the other hand, glycine, the amino acid derived from glyceraldehyde, has no optical activity, as it is not chiral (achiral).

The D/L labeling is unrelated to (+)/(−); it does not indicate which enantiomer is dextrorotatory and which is levorotatory. Rather, it says that the compound's stereochemistry is related to that of the dextrorotatory or levorotatory enantiomer of glyceraldehyde—the dextrorotatory isomer of glyceraldehyde is, in fact, the D- isomer. Nine of the nineteen L-amino acids commonly found in proteins are dextrorotatory (at a wavelength of 589 nm), and D-fructose is also referred to as levulose because it is levorotatory.

A rule of thumb for determining the D/L isomeric form of an amino acid is the "CORN" rule. The groups:
COOH, R, NH2 and H (where R is the side-chain)
are arranged around the chiral center carbon atom. With the hydrogen atom away from the viewer, if the arrangement of the CORN groups around the carbon atom as center is counter-clockwise, then it is the L form.[13] If the arrangement is clockwise, it is the D form. The L form is the usual one found in natural proteins. For most amino acids, the L form corresponds to an S absolute stereochemistry, but is R instead for certain side-chains.

Origin

The Latin for left and right is laevus and dexter, respectively. Left and right have always had moral connotations, and the Latin words for these are sinister and rectus (straight, proper). The English word right is a cognate of rectus. This is the origin of the D,L and S,R notations.

Nomenclature

  • Any non-racemic chiral substance is called scalemic.[14]
  • A chiral substance is enantiopure or homochiral when only one of two possible enantiomers is present.
  • A chiral substance is enantioenriched or heterochiral when an excess of one enantiomer is present but not to the exclusion of the other.
  • Enantiomeric excess or ee is a measure for how much of one enantiomer is present compared to the other. For example, in a sample with 40% ee in R, the remaining 60% is racemic with 30% of R and 30% of S, so that the total amount of R is 70%.

Stereogenic centers

In general, chiral molecules have point chirality at a single stereogenic atom, which has four different substituents. The two enantiomers of such compounds are said to have different absolute configurations at this center. This center is thus stereogenic (i.e., a grouping within a molecular entity that may be considered a focus of stereoisomerism).
Normally, when a tetrahedral atom has four different substituents it is chiral. However, in rare cases, if two of the ligands differ from each other by being mirror images of each other, the mirror image of the molecule is identical to the original, and the molecule is achiral. This is called pseudochirality.

A molecule can have multiple stereogenic centers without being chiral overall if there is a symmetry between the two (or more) stereocenters themselves. Such a molecule is called a meso compound.

It is also possible for a molecule to be chiral without having actual point chirality. Common examples include 1,1'-bi-2-naphthol (BINOL), 1,3-dichloro-allene, and BINAP, which have axial chirality, (E)-cyclooctene, which has planar chirality, and certain calixarenes and fullerenes, which have inherent chirality.

A form of point chirality can also occur if a molecule contains a tetrahedral subunit which cannot easily rearrange, for instance 1-bromo-1-chloro-1-fluoroadamantane and methylethylphenyltetrahedrane.

It is important to keep in mind that molecules have considerable flexibility and thus, depending on the medium, may adopt a variety of different conformations. These various conformations are themselves almost always chiral. When assessing chirality, a time-averaged structure is considered and for routine compounds, one should refer to the most symmetric possible conformation.

When the optical rotation for an enantiomer is too low for practical measurement, it is said to exhibit cryptochirality.

Even isotopic differences must be considered when examining chirality. Replacing one of the two 1H atoms at the CH2 position of benzyl alcohol with a deuterium (2H) makes that carbon a stereocenter.
The resulting benzyl-α-d alcohol exists as two distinct enantiomers, which can be assigned by the usual stereochemical naming conventions. The S enantiomer has [α]D = +0.715°.[15]

The identity of the stereogenic atom

The stereogenic atom in chiral molecules is usually carbon, as in many biological molecules.
However, it may also be a metal atom (as in many chiral coordination compounds), nitrogen, phosphorus, or sulfur.

The chiral atom Carbon Nitrogen Phosphorus (phosphates) Phosphorus (phosphines) Sulfur Metal (type of metal)
1 stereogenic center Serine, glyceraldehyde Sarin, VX Esomeprazole, armodafinil Tris(bipyridine)ruthenium(II) (ruthenium), cis-Dichlorobis(ethylenediamine)cobalt(III) (cobalt), hexol (cobalt)
2 stereogenic centers Threonine, isoleucine Tröger's base Adenosine triphosphate DIPAMP Dithionous acid
3 or more stereogenic centers Met-enkephalin, leu-enkephalin DNA

Properties of enantiomers

Normally, the two enantiomers of a molecule behave identically to each other. For example, they will migrate with identical Rf in thin layer chromatography and have identical retention time in HPLC. Their NMR and IR spectra are identical. However, enantiomers behave differently in the presence of other chiral molecules or objects. For example, enantiomers do not migrate identically on chiral chromatographic media, such as quartz or standard media that have been chirally modified. The NMR spectra of enantiomers are affected differently by single-enantiomer chiral additives such as EuFOD.

Chiral compounds rotate plane polarized light. Each enantiomer will rotate the light in a different sense, clockwise or counterclockwise. Molecules that do this are said to be optically active.

Characteristically, different enantiomers of chiral compounds often taste and smell differently and have different effects as drugs – see below. These effects reflect the chirality inherent in biological systems.

One chiral 'object' that interacts differently with the two enantiomers of a chiral compound is circularly polarised light: An enantiomer will absorb left- and right-circularly polarised light to differing degrees. This is the basis of circular dichroism (CD) spectroscopy. Usually the difference in absorptivity is relatively small (parts per thousand). CD spectroscopy [16] is a powerful analytical technique for investigating the secondary structure of proteins and for determining the absolute configurations of chiral compounds, in particular, transition metal complexes. CD spectroscopy is replacing polarimetry as a method for characterising chiral compounds, although the latter is still popular with sugar chemists.

In biology

Many biologically active molecules are chiral, including the naturally occurring amino acids (the building blocks of proteins) and sugars. In biological systems, most of these compounds are of the same chirality: most amino acids are L and sugars are D. Typical naturally occurring proteins, made of L amino acids, are known as left-handed proteins, whereas D amino acids produce right-handed proteins.

The origin of this homochirality in biology is the subject of much debate.[17] Most scientists believe that Earth life's "choice" of chirality was purely random, and that if carbon-based life forms exist elsewhere in the universe, their chemistry could theoretically have opposite chirality. However, there is some suggestion that early amino acids could have formed in comet dust. In this case, circularly polarised radiation (which makes up 17% of stellar radiation) could have caused the selective destruction of one chirality of amino acids, leading to a selection bias which ultimately resulted in all life on Earth being homochiral.[18]

Enzymes, which are chiral, often distinguish between the two enantiomers of a chiral substrate. One could imagine an enzyme as having a glove-like cavity that binds a substrate. If this glove is right-handed, then one enantiomer will fit inside and be bound, whereas the other enantiomer will have a poor fit and is unlikely to bind.

D-form amino acids tend to taste sweet, whereas L-forms are usually tasteless.[19] Spearmint leaves and caraway seeds, respectively, contain R-(–)-carvone and S-(+)-carvone - enantiomers of carvone.[20] These smell different to most people because our olfactory receptors also contain chiral molecules that behave differently in the presence of different enantiomers.

Chirality is important in context of ordered phases as well, for example the addition of a small amount of an optically active molecule to a nematic phase (a phase that has long range orientational order of molecules) transforms that phase to a chiral nematic phase (or cholesteric phase). Chirality in context of such phases in polymeric fluids has also been studied in this context.[21]

D-amino acid natural abundance

The relative abundances of each of the different D-isomers of several amino acids have recently been quantified by collecting experimentally reported data from the proteome across all organisms in the Swiss-Prot database. The D-isomers observed experimentally were found to occur very rarely as shown in the following table in the database of protein sequences containing over 187 million amino acids.[22]
D-amino acid # of times experimentally observed
D-alanine 664
D-serine 114
D-methionine 19
D-phenylalanine 15
D-valine 8
D-tryptophan 7
D-leucine 6
D-asparagine 2
D-threonine 2

However, the D-isomers are not uncommon as free amino acids. Humans have special enzymes to process then, D-amino acid oxidase and D-aspartate oxidase. D-glutamic acid, D-glutamin, and D-alanine are also extremely common at a part of the peptidoglycan layer in the bacterial cell wall. In addition, D-serine is a neurotransmitter, and produced in humans by serine racemase.

Inorganic chemistry


Delta-ruthenium-tris(bipyridine) cation
 
Many coordination compounds are chiral. At one time, chirality was only associated with organic chemistry, but this misconception was overthrown by the resolution of a purely inorganic compound, hexol, by Alfred Werner. A famous example is tris(bipyridine)ruthenium(II) complex in which the three bipyridine ligands adopt a chiral propeller-like arrangement.[23] In this case, the Ru atom is the stereogenic center. The two enantiomers of complexes such as [Ru(2,2′-bipyridine)3]2+ may be designated as Λ (capital lambda, the Greek version of "L") for a left-handed twist of the propeller described by the ligands, and Δ (capital delta, Greek "D") for a right-handed twist – pictured.

Chirality of compounds with a stereogenic lone pair

When a nonbonding pair of electrons, a lone pair, occupies space, chirality can result. The effect is pervasive in certain amines, phosphines,[24] sulfonium and oxonium ions, sulfoxides, and even carbanions. The main requirement is that aside from the lone pair, the other three substituents differ mutually. Chiral phosphine ligands are useful in asymmetric synthesis.
Geometric inversion among the lone pair and three bonded groups on a tetrahedral amine

Chiral amines are special in the sense that the enantiomers can rarely be separated. The energy barrier for nitrogen inversion of the stereocenter is generally only about 30 kJ/mol, which means that the two stereoisomers rapidly interconvert at room temperature. As a result, such chiral amines cannot be resolved into individual enantiomers unless some of the substituents are constrained in cyclic structures, such as in Tröger's base.

Elon Musk


From Wikipedia, the free encyclopedia

Elon Musk
Elon Musk - The Summit 2013.jpg
Musk at The Summit 2013 in Dublin.
Born (1971-06-28) June 28, 1971 (age 43)
Pretoria, Gauteng, South Africa
Residence Los Angeles, California, United States
Nationality American, Canadian, South African
Education Pretoria Boys High School
Alma mater Queen's University (transferred)
University of Pennsylvania[1][2]
Occupation Entrepreneur, engineer, inventor
Known for SpaceX, PayPal, Tesla Motors, Hyperloop, Zip2, Solar City
Salary US$1 at Tesla Motors (2014)[3]
Net worth Decrease US$7.5 billion (January 2015)[4]
Title CEO and CTO of SpaceX,
Product architect and CEO of Tesla Motors,
Chairman of SolarCity
Spouse(s)
Children 5 sons
Signature Elon Musk
Website
twitter.com/elonmusk

Elon Reeve Musk (/ˈlɒn ˈmʌsk/; born June 28, 1971) is a South Africa-born, Canadian-American entrepreneur, engineer, inventor and investor[5][6][7][8][9]. He is the CEO and CTO of SpaceX, CEO and chief product architect of Tesla Motors, and chairman of SolarCity. He is the founder of SpaceX and a cofounder of PayPal,[10] Tesla Motors, and Zip2.[11][12][13][14] He has also envisioned a conceptual high-speed transportation system known as the Hyperloop.

Early life

Musk was born June 28, 1971, in Pretoria, South Africa,[15] to a Canadian-English mother and prominent model Maye Musk and a South African-born British father and electrical/mechanical engineer Errol Musk.[16][17][18] After his parents divorced in 1980, Musk lived mostly with his father in locations in South Africa.[19] He taught himself computer programming and at age 12 sold the computer code for a video game called Blastar for $500.[20]

Musk attended Waterkloof House Preparatory School before graduating from Pretoria Boys High School and moving to Canada in 1988 at age 17, after obtaining Canadian citizenship through his mother.[21][22] He did so before his South African military service, reasoning that it would be easier to emigrate to the United States from Canada than from South Africa.[20][23][24]

At age 19, Musk was accepted into Queen's University in Kingston, Ontario for undergraduate study, and in 1992, after spending two years at Queen's University, Musk transferred to the University of Pennsylvania where he eventually received a Bachelor of Arts degree in Physics, and a Bachelor of Science degree in Economics from the Wharton School. Musk stayed on a year to finish his second bachelor's degree, a Bachelor of Arts degree in Economics.[25] In 1995, age 24, Musk moved to California to begin a PhD in Applied physics at Stanford, but left the program after two days to pursue his entrepreneurial aspirations in the areas of the Internet, renewable energy and outer space.[20][26] In 2002, he became an American citizen.[23][27]

Career

Zip2

In 1995, Musk started Zip2, a web software company, with his brother, Kimbal. The company developed and marketed an Internet "city guide" for the newspaper publishing industry.[28] Musk obtained contracts with The New York Times and the Chicago Tribune[29] and persuaded the board of directors to abandon plans for a merger with a company called CitySearch.[30] Compaq acquired Zip2 for US$307 million in cash and US$34 million in stock options in 1999.[31] Musk received 7% or $22 million from the sale.[29]

X.com and PayPal

In March 1999, Musk co-founded X.com, an online financial services and e-mail payment company.[28][30] One year later, the company merged with Confinity,[29][32] which had a money transfer service called PayPal. The merged company focused on the PayPal service and was renamed as PayPal in 2001. PayPal's early growth was driven mainly by a viral marketing campaign where new customers were recruited when they received money through the service.[33] In October 2002, PayPal was acquired by eBay for US$1.5 billion in stock, of which $165 million was given to Musk.[34]
Before its sale, Musk, the company's largest shareholder, owned 11.7% of PayPal's shares.[35]

SpaceX

With $100 million of his early fortune,[citation needed] Musk founded his third company, Space Exploration Technologies, or SpaceX, in June 2002.[36] Musk is CEO and Chief Designer (CTO) of the Hawthorne, California-based company. SpaceX develops and manufactures space launch vehicles with a focus on advancing the state of rocket technology. The company's first two launch vehicles are the Falcon 1 and Falcon 9 rockets, and its first spacecraft is the Dragon.[37] In seven years, SpaceX designed the family of Falcon launch vehicles and the Dragon multi-purpose spacecraft from the ground up.[citation needed] In September 2009, SpaceX's Falcon 1 rocket, designed by Musk, became the first privately funded liquid-fuelled vehicle to put a satellite into Earth orbit.[citation needed] On May 25, 2012, the SpaceX Dragon vehicle berthed with the ISS, making history as the first commercial company to launch and berth a vehicle to the International Space Station.[38]

Musk and President Barack Obama at the Falcon 9 launch site in 2010

SpaceX was awarded a contract from NASA in 2006 to develop and test a new launch vehicle, Falcon 9, to transport cargo to the space station,[39] followed by a $1.6 billion NASA contract on December 23, 2008 for 12 flights of its Falcon 9 rocket and Dragon spacecraft to the International Space Station, replacing the Space Shuttle after it retired in 2011. SpaceX is one of two contractors in the Commercial Resupply Services program, which replaces the cargo transport function of the Space Shuttle. Astronaut transport to the ISS is currently handled solely by the Soyuz, but as of 2014 SpaceX is also one of two companies remaining in the Commercial Crew Development program, which is intended to develop a US astronaut transport capability.

Musk was influenced by Isaac Asimov's Foundation series[40] and views space exploration as an important step in expanding—if not preserving—the consciousness of human life.[41]

Musk said that multiplanetary life may serve as a hedge against threats to the survival of the human species. "An asteroid or a super volcano could destroy us, and we face risks the dinosaurs never saw: an engineered virus, inadvertent creation of a micro black hole, catastrophic global warming or some as-yet-unknown technology could spell the end of us. Humankind evolved over millions of years, but in the last sixty years atomic weaponry created the potential to extinguish ourselves. Sooner or later, we must expand life beyond this green and blue ball—or go extinct." His goal is to reduce the cost of human spaceflight by a factor of 10.[42] In a 2011 interview, he said he hopes to send humans to Mars' surface within 10–20 years.[43]

The SpaceX factory was used as a filming location for Iron Man 2 's Hammer Industries, and Musk has a cameo in the movie.[44]

Tesla Motors

Musk observing an assembly demo at the reopening of the NUMMI plant, now known as the Tesla Factory (Fremont, CA) in 2010

The company was co-founded by Martin Eberhard, Marc Tarpenning, JB Straubel, and Ian Wright in 2003.[45] A year later Elon Musk invested in the company and became Chairman.[45] Other Series A investments groups included SDL Ventures and Compass Technology Partners. Following the financial crisis in 2008,[46] Musk assumed leadership of the company as CEO and product architect, positions he still holds today. Tesla Motors first built an electric sports car, the Tesla Roadster, with sales of about 2,500 vehicles to 31 countries. Tesla began delivery of its four-door Model S sedan on June 22, 2012 and unveiled its third product, the Model X, aimed at the SUV/minivan market, on February 9, 2012. Model X is scheduled to begin production in early 2015.[47] In addition to its own cars, Tesla sells electric powertrain systems to Daimler for the Smart EV, Mercedes B-Class Electric Drive and Mercedes A Class and to Toyota for the RAV4 EV. Musk was able to bring in both companies as long-term investors in Tesla.[48]

Musk and Senator Dianne Feinstein next to a Tesla Model S (2010)

Musk has favored building a sub-$30,000 subcompact and building and selling electric vehicle powertrain components so that other automakers can produce electric vehicles at affordable prices without having to develop the products in house.[49] Several mainstream publications have compared him with Henry Ford for his work on advanced vehicle powertrains.[50]

To overcome the range limitations of electric cars, Musk said in an interview with All Things D in May 2013 that Tesla is "dramatically accelerating" their network of supercharger stations, tripling the number on the East and West coasts of the U.S. that June, with plans for more expansion across North America, including Canada, throughout the year.[51] He is reported to have a 32% stake in Tesla, which is valued at US$18 billion, as of November 2013.[52][53] His annual salary at Tesla is one dollar, and similar to Steve Jobs and others, the remainder of his compensation is in the form of stock and performance-based bonuses.[3][54]

Technology sharing

Tesla CEO Elon Musk announced in a press release and conference call and blog post[55] on June 12, 2014 that the company will allow its technology patents for use by anyone in good faith, in a bid to entice automobile manufacturers to speed up development of electric cars. "The unfortunate reality is electric car programs (or programs for any vehicle that doesn't burn hydrocarbons) at the major manufacturers are small to non-existent, constituting an average of far less than 1% of their total vehicle sales," he said at the time.

SolarCity

Musk provided the initial concept for SolarCity, which was then co-founded in 2006 by his cousins Lyndon and Peter Rive.[56][57] Musk remains the largest shareholder. SolarCity is now the second largest provider of solar power systems in the United States.[58]
The underlying motivation for funding both SolarCity and Tesla is to help combat global warming.[59] In 2012, Musk announced that SolarCity and Tesla Motors are collaborating to use electric vehicle batteries to smooth the impact of rooftop solar on the power grid, with the program going live in 2013.[60]

On June 17, 2014, Musk committed to building a SolarCity advanced production facility in Buffalo, NY that would triple the size of the largest solar plant in the United States. Musk stated the plant will be "one of the single largest solar panel production plants in the world," and it will be followed by one or more even bigger facilities in subsequent years.[61]

Hyperloop

On August 12, 2013, Musk unveiled a proposal for a new form of transportation between the Greater Los Angeles area and the San Francisco Bay Area, after being disappointed with the approved California High-Speed Rail system.[62] After envisioning Hyperloop, Musk assigned a dozen engineers from Tesla Motors and SpaceX who worked for nine months, establishing the conceptual foundations and creating the designs for the transportation system.[63] An early design for the system was then published in a whitepaper posted to the Tesla and SpaceX blogs.[64][65] Musk named it "hyperloop," a hypothetical subsonic air travel machine that stretches approximately 350 miles (560 km) from Sylmar (a northern district of Los Angeles) to Hayward (east of San Francisco) and would theoretically allow commuters to travel between the cities in 35 minutes or less, providing a shorter traveling time than even a commercial airplane can currently provide.[66] Musk's proposal, if technologically feasible at the costs he has cited, would make travel cheaper than any other mode of transport for such long distances. The system is proposed to use a partial vacuum to reduce aerodynamic drag, which it is theorized would allow for high speed travel with relatively low power. 
He has estimated the total cost of the system at $6 billion, but this amount is speculative.[67] It was proposed to rely completely on solar energy for all power requirements. On January 15, 2015 Elon Musk announced via Twitter that he would be building a 5 mile long Hyperloop track most likely in Texas for students and companies to work with. [68]

Philanthropy


Musk speaking alongside Irish Taoiseach (Prime Minister) Enda Kenny

Musk is chairman of the Musk Foundation, which focuses its philanthropic efforts on science education, paediatric health, and clean energy. In 2010, the foundation created a program focused on donating solar-power systems for critical needs in disaster areas. The first such solar-power installation was donated to a hurricane response center in Alabama that had been neglected by state and federal aid. To make it clear that this program was not serving Musk's own commercial interests, SolarCity noted that it had no presence or planned business activity in that state.[69] In a 2011 visit to Soma City in Fukushima, Japan, which had been devastated by tsunami, Musk donated a solar power project valued at $250,000 to the city.[70]

Musk had plans for a "Mars Oasis" project in 2001, which would land a miniature experimental greenhouse on Mars, containing food crops growing on Martian regolith.[71][72] Ultimately Musk ended up founding SpaceX with the long-term goal of creating a true spacefaring civilization.[73]
Musk's philosophy and description of what is needed to solve the problem are provided in the IEEE podcast "Elon Musk: a founder of PayPal, Tesla Motors, and SpaceX"[74] and article "Risky Business."[72]

In April 2012, Musk joined The Giving Pledge, offering an ethical commitment to donate the majority of his fortune to philanthropic causes.[75] Musk became a member of the campaign first popularised by Warren Buffett and Bill Gates with a class of 12 of America's wealthiest families and individuals.[75]

In January 2015 Musk donated $10M to the Future of Life Institute to run a global research program aimed at keeping artificial intelligence beneficial to humanity.[76]

Car blog Jalopnik reported on August 16, 2012 that Musk was supporting an effort by Matthew Inman of The Oatmeal to preserve the site of Nikola Tesla's lab on Long Island, New York and turn it into a museum, the Tesla Science Center at Wardenclyffe.[77] After further discussion with Inman, Elon Musk agreed to donate $1 million toward the construction of a museum on the Wardenclyffe property. As well, Musk pledged to build a Tesla Supercharger station for use in the museum's parking lot.[78][79]

Musk is a trustee of the X Prize Foundation, promoting renewable-energy technologies. He also sits on the boards of The Space Foundation, The National Academies Aeronautics and Space Engineering Board, Stanford Engineering Advisory Board and on the board of trustees of Caltech.[80]

Positions and opinions

Politically, Musk has described himself as half-democrat, half-republican. In his own words "I'm somewhere in the middle, socially liberal and fiscally conservative."[81]

Musk had been a supporter of the U.S. Political action committee FWD.us, which was started by fellow high-profile entrepreneur Mark Zuckerberg and advocates for immigration reform. However, in May 2013, Musk publicly withdrew his support in protest of advertisements the PAC was running that supported causes like the Keystone Pipeline. Musk and other members, including David Sacks, pulled out, criticizing the strategy as "cynical."[82]

When asked about his views on the "destiny" and grandness of the universe Musk responded:
Do I think that there's some sort of master intelligence architecting all of this stuff? I think probably not because then you have to say: "Where does the master intelligence come from?" So it sort of begs the question. So I think really you can explain this with the fundamental laws of physics. You know its complex phenomenon from simple elements.[83]
Musk has also stated that he hopes there is other intelligent life in the known universe. In his own words, intelligent life in the universe is "probably more likely than not, but that's a complete guess."[84]

Personal life

Musk previously owned a McLaren F1 sports car, however he crashed and 'wrecked' the car while it was uninsured.[85] He also previously owned a Czech-made jet trainer aircraft Aero L-39.[86] The 1994 model Dassault Falcon 900 aircraft used in the 2005 film Thank You for Smoking is registered to Musk (N900SX),[87] and Musk had a cameo as the pilot of his plane, opening the door for Robert Duvall and escorting Aaron Eckhart aboard. Musk owns Wet Nellie, the Lotus Esprit from the James Bond film The Spy Who Loved Me. He plans to convert it into the functional car-submarine from the film.[88] Musk attended the Burning Man festival in 2004 and has said he first thought up the idea for SolarCity at the festival.[60]

Musk has been married twice. He met his first wife, the Canadian author Justine Musk (née Wilson), while both were students at Ontario's Queen's University, Kingston. They married in 2000 and separated eight years later, after having six sons, five of whom they share custody.[18] Their first son, Nevada Alexander, died of SIDS when he was 10 weeks old.[89][90] Following the divorce, Justine Musk gave an interview describing her marriage with Musk in Marie Claire magazine.[91] Musk announced in January 2012 that he had recently ended a four-year relationship with his second wife, British actress Talulah Riley.[18][92] On January 18, 2012, he tweeted to Riley, "It was an amazing four years. I will love you forever. You will make someone very happy one day."[93] Later in July 2013, he decided to remarry his second wife. On February 11, 2014, Musk was invited to attend a state dinner at the White House, and the guest list included Mr. Elon Musk and Mrs. Talulah Musk.[94] In a 60 Minutes interview on March 30, 2014, with CBS journalist Scott Pelley, Elon and Talulah are shown to still be together with Elon's five children from his first marriage.[95] Finally, in December 2014 he filed for a second divorce from her.[96]

Tosca Musk, Elon's sister, is the founder of Musk Entertainment and has produced various movies.[97]

Awards and recognition

Musk is a Trustee of The X-Prize Foundation and a member of the Stanford University Engineering Advisory Board. He has previously served as a member of the United States National Academy of Sciences Aeronautics and Space Engineering Board.[117] In a 2010 Space Foundation survey, he was ranked as the No. 10 (tied with rocketry pioneer and scientist Wernher von Braun) most popular space hero.[118]

Honorary doctorates


Natural science

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