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Tuesday, August 5, 2014

It's precisely this power that makes Showalter's biomedical research possible.

Scientist uses giant spectrometer to search for cure for cancer

Scientist uses giant spectrometer to search for cure for cancer
Scott Showalter, a researcher and associate professor of chemistry, in his lab in the Chemistry Building. Credit: Lauren Ingram
A pro at navigating the labyrinthine hallways in the Chemistry Building, Scott Showalter, researcher and associate professor of chemistry in Penn State's Eberly College of Science, maneuvers from his office, class and a handful of laboratories throughout the day. But it's one workspace in particular, home to the ScholarSphere, a drum-shaped hunk of machinery—essentially a gigantic MRI on stilts—where Showalter is moving closer to the biomedical breakthrough he so desires.

Showalter wants to help find a cure for cancer.

By harnessing the power of the mammoth instrument, a nuclear magnetic resonance (NMR) spectrometer, he is able to study the chemical structures of invisible-to-the-eye atoms stored in vials no larger than ballpoint pens.

The irony of the disproportion is not lost on him.

"We're using this gigantic machine to fine-tune new methods for studying disordered proteins of microscopic proportions—of which 70 percent can be disease causing," Showalter said.

Proteins are important to health because they regulate gene expression and execute cell function, which can, for example, play a role in determining whether or not a pancreas creates enough insulin or if a cellular mutation will become cancerous.

"These disordered proteins are too small to study under a microscope, but the behavior of the infinitesimal magnets in the atoms that comprise the proteins are the key to our work," Showalter explained. "So, we're putting the atoms in the presence of the biggest magnet we can find to get them dancing: a NMR spectrometer."

The spectrometer uses an ultrastrong magnet and radio frequency circuitry similar to an FM radio to analyze the atom's structure in ways other tools can't.

Scientist uses giant spectrometer to search for cure for cancer
Showalter uses a nuclear magnetic resonance (NMR) spectrometer to fine-tune new methods for studying disordered proteins. Credit: Lauren Ingram
Used by Penn State scientists for all kinds of research, the spectrometer packs a punch so strong—emitting a magnetic field nearly half a million times stronger than that of the earth below State College—that any smartphone, laptop or pacemaker that comes within its vicinity is fried.
It's precisely this power that makes Showalter's possible.

By developing original methods for understanding these intrinsically disordered proteins (a relatively new field of biochemistry), Showalter and his team can provide researchers around the world with the knowledge and resources they need to design drug targets for treating such maladies as cancer, diabetes and hepatitis C.

"Unlike the other two-thirds of the proteins in our bodies, these disordered proteins are constantly changing form. At this point, scientists don't understand them well enough to efficiently design drug molecules that can interact with them," said Showalter. "Our primary goal is to understand them better on a fundamental level because the process of finding a drug is either going to be a very expensive, unguided fishing expedition or a well-informed, strategic collaboration."
As one of the preliminary steps in this process, Showalter and his team are not only writing the code for and running the new experiments; they also are sharing their potentially life-saving findings with the world.

"Developing the code to conduct experiments on the NMR spectrometer is not easy. There are many, many scientists who are capable of using these instruments but who don't consider themselves to be code developers," Showalter said. "We're broadly disseminating data files other people can upload to their NMR spectrometers so they can do the experiments, too."
As part of his for publicly disseminating his research findings (a mandate of his National Science Foundation grant), Showalter shares the results of his original experiments in research journals and also uploads the code for the experiments into ScholarSphere, Penn State's digital repository for curating and preserving research and scholarly data.

Scientist uses giant spectrometer to search for cure for cancer
The atoms Showalter and his team study are placed in vials the sizes of ballpoint pens and tested in the NMR spectrometer. Credit: Lauren Ingram

By openly sharing the original experiments with scientists around the world using the repository service, Showalter and his team are widening the net of researchers who can use the same NMR techniques to conduct their own biomedical research.
So far, it's working.

After reading a paper written by Showalter and team in the Journal of Physical Chemistry Letters, which linked to the experiment's code in ScholarSphere, a scientist at the Scripps Research Institute in Florida downloaded the data set and reached out to Showalter with some follow-up questions.

Scientist uses giant spectrometer to search for cure for cancer
Bastidas prepares a sample for the spectrometer. Credit: Penn State
It's having this kind of broad impact that gets Showalter out of bed in the morning.
"Our field is growing really quickly, and it's been a lot of fun to be part of a new area of biochemistry and to be able to make major contributions with a technique that I care about. It has been pretty inspiring," Showalter said. "I'm not a medical doctor, so anything that we might be able to do that can influence biomedicine and build bridges to the doctors and nurses who have a direct effect on a patient's health is my goal. I can't get there on my own, but hopefully together, we can help make innovations happen faster."
Explore further: Minuscule chips for NMR spectroscopy promise portability, parallelization

Stephen Jay Gould

Stephen Jay Gould

Condensed from Wikipedia, the free encyclopedia
Stephen Jay Gould
Stephen Jay Gould by Kathy Chapman.png
BornSeptember 10, 1941
Bayside, New York, United States
DiedMay 20, 2002(2002-05-20) (aged 60)
Manhattan, New York, United States
NationalityAmerican
FieldsPaleontology, Evolutionary biology History of Science
InstitutionsHarvard University,
American Museum of Natural History,
New York University
Alma materAntioch College,
Columbia University
ThesisPleistocene and Recent History of the Subgenus Poecilozonites (Poecilozonites) (Gastropoda: Pulmonata) in Bermuda: An Evolutionary Microcosm (1967)
Doctoral advisorR. L. Batten
J. Imbrie
Norman D. Newell
Known forPunctuated equilibrium, Non-overlapping magisteria
Notable awardsLinnean Society of London's Darwin–Wallace Medal (2008)
Paleontological Society Medal (2002)
Sue Tyler Friedman Medal (1989)
Charles Schuchert Award (1975)
Phi Beta Kappa Award in Science (twice – 1983, 1990)
MacArthur Fellowship
National Book Award
National Book Critics Circle Award
SpouseDeborah Lee (1965–?; divorced; 2 children)
Rhonda Roland Shearer (1995–2002; his death; 2 stepchildren)
Signature
Stephen Jay Gould (/ɡld/; September 10, 1941 – May 20, 2002) was an American paleontologist, evolutionary biologist and historian of science. He was also one of the most influential and widely read writers of popular science of his generation.[1] Gould spent most of his career teaching at Harvard University and working at the American Museum of Natural History in New York. In the later years of his life, Gould also taught biology and evolution at New York University.

Gould's most significant contribution to evolutionary biology was the theory of punctuated equilibrium, which he developed with Niles Eldredge in 1972.[2] The theory proposes that most evolution is marked by long periods of evolutionary stability, which is punctuated by rare instances of branching evolution. The theory was contrasted against phyletic gradualism, the popular idea that evolutionary change is marked by a pattern of smooth and continuous change in the fossil record.

Most of Gould's empirical research was based on the land snail genera Poecilozonites and Cerion. He also contributed to evolutionary developmental biology, and has received wide praise for his book Ontogeny and Phylogeny. In evolutionary theory he opposed strict selectionism, sociobiology as applied to humans, and evolutionary psychology. He campaigned against creationism and proposed that science and religion should be considered two distinct fields (or "magisteria") whose authorities do not overlap.[3]

Gould was known by the general public mainly from his 300 popular essays in the magazine Natural History,[4] and his books written for a non-specialist audience. In April 2000, the US Library of Congress named him a "Living Legend".[5]

Scientific career

Gould began his higher education at Antioch College, graduating with a double major in geology and philosophy in 1963.[20] During this time, he also studied at the University of Leeds in the United Kingdom.[21] After completing graduate work at Columbia University in 1967 under the guidance of Norman Newell, he was immediately hired by Harvard University where he worked until the end of his life (1967–2002). In 1973, Harvard promoted him to Professor of Geology and Curator of Invertebrate paleontology at the institution's Museum of Comparative Zoology; he very often described himself as a taxonomist.

In 1982 Harvard awarded him the title of Alexander Agassiz Professor of Zoology. The following year, 1983, he was awarded fellowship of the American Association for the Advancement of Science, where he later served as president (1999–2001). The AAAS news release cited his "numerous contributions to both scientific progress and the public understanding of science". He also served as president of the Paleontological Society (1985–1986) and of the Society for the Study of Evolution (1990–1991).

In 1989 Gould was elected into the body of the National Academy of Sciences. Through 1996–2002 Gould was Vincent Astor Visiting Research Professor of Biology at New York University. In 2001, the American Humanist Association named him the Humanist of the Year for his lifetime of work. In 2008, he was posthumously awarded the Darwin-Wallace Medal, along with 12 other recipients. (Until 2008 this medal had been awarded every 50 years by the Linnean Society of London.[22])

Punctuated equilibrium

Early in his career, Gould and Niles Eldredge developed the theory of punctuated equilibrium, according to which evolutionary change occurs relatively rapidly, alternating with longer periods of relative evolutionary stability.[2] Although Gould suggested the term itself, the basic concept was first presented in Eldredge's doctoral dissertation on Devonian trilobites and in an article published the previous year on allopatric speciation.[23] According to Gould, punctuated equilibrium revised a key pillar "in the central logic of Darwinian theory".[8]

Some evolutionary biologists have argued that while punctuated equilibrium was "of great interest to biology",[24] it merely modified neo-Darwinism in a manner that was fully compatible with what had been known before.[25] For example, George Gaylord Simpson, in Tempo and Mode in Evolution (1941), described evolutionary history as being characterized by long periods of stasis (bradytely) or gradual change (horotely), punctuated by short bursts of rapid change (tachytely). This description of evolutionary change, however, is not a theory of the process(es) that produces it. Punctuated equilibrium is such a theory.

Others have emphasized the theoretical novelty of punctuated equilibrium, and argued that evolutionary stasis had been "unexpected by most evolutionary biologists" and "had a major impact on paleontology and evolutionary biology".[26]

Gould criticized the "Darwinian Fundamentalism" of John Maynard Smith, Richard Dawkins, and Daniel Dennett.[27]

Some critics jokingly referred to the theory as "evolution by jerks",[28] which elicited Gould to respond in kind by describing gradualism as "evolution by creeps".[29]

Evolutionary developmental biology

Gould made significant contributions to evolutionary developmental biology,[30] especially in his work Ontogeny and Phylogeny.[20] In this book he emphasized the process of heterochrony, which encompasses two distinct processes: pedomorphosis and terminal additions. Pedomorphosis is the process where ontogeny is slowed down and the organism does not reach the end of its development.
Terminal addition is the process by which an organism adds to its development by speeding and shortening earlier stages in the developmental process. Gould's influence in the field of evolutionary developmental biology continues to be seen in such areas as the study of evolution of feathers.[31]

Selectionism and sociobiology

Gould championed biological constraints such as the limitations of developmental pathways on evolutionary outcomes, as well as other non-selectionist forces in evolution. In particular, he considered many higher functions of the human brain to be the unintended side consequence or by-product of natural selection, rather than direct adaptations. To describe such co-opted features he coined the term exaptation with Elisabeth Vrba.[32] Gould believed this understanding undermines an essential premise of human sociobiology and evolutionary psychology.

Against "Sociobiology"

In 1975, Gould's Harvard colleague E. O. Wilson introduced his analysis of animal behavior (including human behavior) based on a sociobiological framework that suggested that many social behaviors have a strong evolutionary basis.[33] In response, Gould, Richard Lewontin, and others from the Boston area wrote the subsequently well-referenced letter to The New York Review of Books entitled, "Against 'Sociobiology'". This open letter criticized Wilson's notion of a "deterministic view of human society and human action".[34]

But Gould did not rule out sociobiological explanations for many aspects of animal behavior, and later wrote: "Sociobiologists have broadened their range of selective stories by invoking concepts of inclusive fitness and kin selection to solve (successfully I think) the vexatious problem of altruism—previously the greatest stumbling block to a Darwinian theory of social behavior... Here sociobiology has had and will continue to have success. And here I wish it well. For it represents an extension of basic Darwinism to a realm where it should apply."[35]

Spandrels and the Panglossian Paradigm

A spandrel from the Holy Trinity Church in Fulnek, Czech Republic.

With Richard Lewontin, Gould wrote an influential 1979 paper entitled, "The Spandrels of San Marco and the panglossian paradigm",[36] which introduced the architectural term "spandrel" into evolutionary biology. In architecture, a spandrel is a curved area of masonry which exists between arches supporting a dome. Spandrels, also called pendentives in this context, are found particularly in Gothic churches.

When visiting Venice in 1978, Gould noted that the spandrels of the San Marco cathedral, while quite beautiful, were not spaces planned by the architect. Rather the spaces arise as "necessary architectural byproducts of mounting a dome on rounded arches." Gould and Lewontin thus defined "spandrels" in the evolutionary biology context, to mean any biological feature of an organism that arises as a necessary side consequence of other features, which is not directly selected for by natural selection.
Proposed examples include the "masculinized genitalia in female hyenas, exaptive use of an umbilicus as a brooding chamber by snails, the shoulder hump of the giant Irish deer, and several key features of human mentality."[37]

In Voltaire's Candide, Dr. Pangloss is portrayed as a clueless scholar who, despite the evidence, insists that "all is for the best in this best of all possible worlds". Gould and Lewontin asserted that it is Panglossian for evolutionary biologists to view all traits as atomized things that had been naturally selected for, and criticised biologists for not granting theoretical space to other causes, such as phyletic and developmental constraints. The relative frequency of spandrels, so defined, versus adaptive features in nature, remains a controversial topic in evolutionary biology.[38] An illustrative example of Gould's approach can be found in Elisabeth Lloyd's case study suggesting that the female orgasm is a by-product of shared developmental pathways.[39] Gould also wrote on this topic in his essay "Male Nipples and Clitoral Ripples",[40] prompted by Lloyd's earlier work.

Evolutionary progress

Gould favored the argument that evolution has no inherent drive towards long-term "progress". Uncritical commentaries often portray evolution as a ladder of progress, leading towards bigger, faster, and smarter organisms, the assumption being that evolution is somehow driving organisms to get more complex and ultimately more like humankind. Gould argued that evolution's drive was not towards complexity, but towards diversification. Because life is constrained to begin with a simple starting point ( like bacteria), any diversity resulting from this start, by random walk, will have a skewed distribution and therefore be perceived to move in the direction of higher complexity. But life, Gould argued, can also easily adapt towards simplification, as is often the case with parasites.[41]

In a review of Full House, Richard Dawkins approved of Gould's general argument, but suggested that he saw evidence of a "tendency for lineages to improve cumulatively their adaptive fit to their particular way of life, by increasing the numbers of features which combine together in adaptive complexes. ... By this definition, adaptive evolution is not just incidentally progressive, it is deeply, dyed-in-the-wool, indispensably progressive."[42]

Cladistics

Gould never embraced cladistics as a method of investigating evolutionary lineages and process, possibly because he was concerned that such investigations would lead to neglect of the details in historical biology, which he considered all-important. In the early 1990s this led him into a debate with Derek Briggs, who had begun to apply quantitative cladistic techniques to the Burgess Shale fossils, about the methods to be used in interpreting these fossils.[43] Around this time cladistics rapidly became the dominant method of classification in evolutionary biology. Inexpensive but increasingly powerful personal computers made it possible to process large quantities of data about organisms and their characteristics. Around the same time the development of effective polymerase chain reaction techniques made it possible to apply cladistic methods of analysis to biochemical and genetic features as well.[44]

Technical work on land snails

Most of Gould's empirical research pertained to land snails. He focused his early work on the Bermudian genus Poecilozonites, while his later work concentrated on the West Indian genus Cerion.
According to Gould "Cerion is the land snail of maximal diversity in form throughout the entire world. There are 600 described species of this single genus. In fact, they're not really species, they all interbreed, but the names exist to express a real phenomenon which is this incredible morphological diversity. Some are shaped like golf balls, some are shaped like pencils. ... Now my main subject is the evolution of form, and the problem of how it is that you can get this diversity amid so little genetic difference, so far as we can tell, is a very interesting one. And if we could solve this we'd learn something general about the evolution of form."[45]

Given Cerion's extensive geographic diversity, Gould later lamented that if Christopher Columbus had only cataloged a single Cerion it would have ended the scholarly debate about which island Columbus had first set foot on in America.[46]

Influence

Gould is one of the most frequently cited scientists in the field of evolutionary theory. His 1979 "spandrels" paper has been cited more than 4,000 times.[47] In Paleobiology—the flagship journal of his own speciality—only Charles Darwin and George Gaylord Simpson have been cited more often.[48] Gould was also a considerably respected historian of science. Historian Ronald Numbers has been quoted as saying: "I can't say much about Gould's strengths as a scientist, but for a long time I've regarded him as the second most influential historian of science (next to Thomas Kuhn)."[49]

The Structure of Evolutionary Theory

Shortly before his death, Gould published a long treatise recapitulating his version of modern evolutionary theory: The Structure of Evolutionary Theory (2002).

As a public figure

Gould became widely known through his popular essays on evolution in the Natural History magazine. His essays were published in a series titled This View of Life (a phrase from the concluding paragraph of Charles Darwin's Origin of Species) starting from January 1974 and ended in January 2001, amounting to a continuous publication of 300 essays.[4] Many of his essays were reprinted in collected volumes that became bestselling books such as Ever Since Darwin and The Panda's Thumb, Hens' Teeth and Horses' Toes, and The Flamingo's Smile.

A passionate advocate of evolutionary theory, Gould wrote prolifically on the subject, trying to communicate his understanding of contemporary evolutionary biology to a wide audience. A recurring theme in his writings is the history and development of pre-evolutionary and evolutionary thought. He was also an enthusiastic baseball fan and sabermetrician, and made frequent reference to the sport in his essays. Many of his baseball essays were anthologized in his posthumously published book Triumph and Tragedy in Mudville (2003).[50]

Although a proud Darwinist, Gould's emphasis was less gradualist and reductionist than most neo-Darwinists. He fiercely opposed many aspects of sociobiology and its intellectual descendant evolutionary psychology. He devoted considerable time to fighting against creationism, creation science, and intelligent design. Most notably, Gould provided expert testimony against the equal-time creationism law in McLean v. Arkansas. Gould later developed the term "non-overlapping magisteria" (NOMA) to describe how, in his view, science and religion could not comment on each other's realm. Gould went on to develop this idea in some detail, particularly in the books Rocks of Ages (1999) and The Hedgehog, the Fox, and the Magister's Pox (2003). In a 1982 essay for Natural History Gould wrote:
Our failure to discern a universal good does not record any lack of insight or ingenuity, but merely demonstrates that nature contains no moral messages framed in human terms. Morality is a subject for philosophers, theologians, students of the humanities, indeed for all thinking people. The answers will not be read passively from nature; they do not, and cannot, arise from the data of science. The factual state of the world does not teach us how we, with our powers for good and evil, should alter or preserve it in the most ethical manner.[51]
The anti-evolution petition A Scientific Dissent From Darwinism spawned the National Center for Science Education's pro-evolution counterpart Project Steve, which is named in Gould's honor.[52]

Gould also became a noted public face of science, often appearing on television. In 1984 Gould received his own NOVA special on PBS.[53] Other appearances included interviews on CNN's Crossfire, NBC's The Today Show, and regular appearances on the Charlie Rose show. Gould was also a guest in all seven episodes of the Dutch talk series A Glorious Accident, in which he appeared with Oliver Sacks.[54]

Gould was featured prominently as a guest in Ken Burns's PBS documentary Baseball, as well as PBS's Evolution series. Gould was also on the Board of Advisers to the influential Children's Television Workshop television show 3-2-1 Contact, where he made frequent guest appearances.

In 1997 he voiced a cartoon version of himself on the television series The Simpsons. In the episode "Lisa the Skeptic", Lisa finds a skeleton that many people believe is an apocalyptic angel. Lisa contacts Gould and asks him to test the skeleton's DNA. The fossil is discovered to be a marketing gimmick for a new mall.[55] During production the only phrase Gould objected to was a line in the script that introduced him as the "world's most brilliant paleontologist".[56] In 2002 the show paid tribute to Gould after his death, dedicating the season 13 finale to his memory. Gould had died two days before the episode aired.

Controversy

Gould received many accolades for his scholarly work and popular expositions of natural history,[18][57] but was not immune from criticism by biologists who felt his public presentations were out of step with mainstream evolutionary theory.[58] The public debates between Gould's supporters and detractors have been so quarrelsome that they have been dubbed "The Darwin Wars" by several commentators.[59][60][61][62][63]

John Maynard Smith, an eminent British evolutionary biologist, was among Gould's strongest critics. Maynard Smith thought that Gould misjudged the vital role of adaptation in biology, and was critical of Gould's acceptance of species selection as a major component of biological evolution.[64] In a review of Daniel Dennett's book Darwin's Dangerous Idea, Maynard Smith wrote that Gould "is giving non-biologists a largely false picture of the state of evolutionary theory."[65] But Maynard Smith has not been consistently negative, writing in a review of The Panda's Thumb that "Stephen Gould is the best writer of popular science now active... Often he infuriates me, but I hope he will go right on writing essays like these."[66] Maynard Smith was also among those who welcomed Gould's reinvigoration of evolutionary paleontology.[25]

One reason for criticism was that Gould appeared to be presenting his ideas as a revolutionary way of understanding evolution, and argued for the importance of mechanisms other than natural selection, mechanisms which he believed had been ignored by many professional evolutionists. As a result, many non-specialists sometimes inferred from his early writings that Darwinian explanations had been proven to be unscientific (which Gould never tried to imply). Along with many other researchers in the field, Gould's works were sometimes deliberately taken out of context by creationists as "proof" that scientists no longer understood how organisms evolved.[67] Gould himself corrected some of these misinterpretations and distortions of his writings in later works.[68]

As documented by Kim Sterelny among others, Gould disagreed with Richard Dawkins about the importance of gene selection in evolution. Dawkins argued that evolution is best understood as competition among genes (or replicators), while Gould advocated the importance of multi-level selection, including selection amongst genes, cell lineages, organisms, demes, species, and clades.[62]

Dawkins also found that Gould deliberately played down the difference between rapid gradualism and macromutation in his theory of punctuated equilibrium.[69] Criticism of Gould and his theory of punctuated equilibrium can be found in Dawkins' The Blind Watchmaker and Unweaving the Rainbow, as well as chapter 10 of Dennett's Darwin's Dangerous Idea.

Cambrian fauna

Gould's interpretation of the Cambrian Burgess Shale fossils in his book Wonderful Life emphasized the striking morphological disparity (or "weirdness") of the Burgess Shale fauna, and the role of chance in determining which members of this fauna survived and flourished. He used the Cambrian fauna as an example of the role of contingency in the broader pattern of evolution.

His view was criticized by Simon Conway Morris in his 1998 book The Crucible of Creation.[70] Conway Morris stressed those members of the Cambrian fauna that resemble modern taxa. He also promoted convergent evolution as a mechanism producing similar forms in similar environmental circumstances, and argued in a subsequent book that the appearance of human-like animals is likely.
Paleontologists Derek Briggs and Richard Fortey have also argued that much of the Cambrian fauna may be regarded as stem groups of living taxa,[71] though this is still a subject of intense research and debate, and the relationship of many Cambrian taxa to modern phyla has not been established in the eyes of many palaeontologists.

Paleontologist Richard Fortey noted that prior to the release of Wonderful Life, Conway Morris shared many of Gould's sentiments and views. It was only after publication of Wonderful Life that Conway Morris revised his interpretation and adopted a more progressive stance towards the history of life.[72]

Richard Dawkins also disagreed with Gould's interpretation of the Burgess Shale, arguing:
The extreme Gouldian view—certainly the view inspired by his rhetoric, though it is hard to tell from his own words whether he literally holds it himself—is radically different from and utterly incompatible with the standard neo-Darwinian model. ... For a new body plan—a new phylum—to spring into existence, what actually has to happen on the ground is that a child is born which suddenly, out of the blue, is as different from its parents as a snail is from an earthworm. No zoologist who thinks through the implications, not even the most ardent saltationist, has ever supported any such notion.[73]

Opposition to sociobiology and evolutionary psychology

Gould also had a long-running public feud with E. O. Wilson and other evolutionary biologists about human sociobiology and its later descendant evolutionary psychology (which Gould, Lewontin, and Maynard Smith opposed, but which Richard Dawkins, Daniel Dennett, and Steven Pinker advocated).[74] These debates reached their climax in the 1970s, and included strong opposition from groups like the Sociobiology Study Group and Science for the People.[75] Pinker accuses Gould, Lewontin, and other opponents of evolutionary psychology of being "radical scientists", whose stance on human nature is influenced by politics rather than science.[76] Gould stated that he made "no attribution of motive in Wilson's or anyone else's case" but cautioned that all human beings are influenced, especially unconsciously, by our personal expectations and biases. He wrote:
I grew up in a family with a tradition of participation in campaigns for social justice, and I was active, as a student, in the civil rights movement at a time of great excitement and success in the early 1960s. Scholars are often wary of citing such commitments. … [but] it is dangerous for a scholar even to imagine that he might attain complete neutrality, for then one stops being vigilant about personal preferences and their influences—and then one truly falls victim to the dictates of prejudice. Objectivity must be operationally defined as fair treatment of data, not absence of preference.[77]
Gould's primary criticism held that human sociobiological explanations lacked evidential support, and argued that adaptive behaviors are frequently assumed to be genetic for no other reason than their supposed universality, or their adaptive nature. Gould emphasized that adaptive behaviors can be passed on through culture as well, and either hypothesis is equally plausible.[78] Gould did not deny the relevance of biology to human nature, but reframed the debate as "biological potentiality vs. biological determinism". Gould stated that the human brain allows for a wide range of behaviors. Its flexibility "permits us to be aggressive or peaceful, dominant or submissive, spiteful or generous…
Violence, sexism, and general nastiness are biological since they represent one subset of a possible range of behaviors. But peacefulness, equality, and kindness are just as biological—and we may see their influence increase if we can create social structures that permit them to flourish."[78]

The Mismeasure of Man

Gould was the author of The Mismeasure of Man (1981), a history and inquiry of psychometrics and intelligence testing. Gould investigated the methods of nineteenth century craniometry, as well as the history of psychological testing. Gould claimed that both theories developed from an unfounded belief in biological determinism, the view that "social and economic differences between human groups—primarily races, classes, and sexes—arise from inherited, inborn distinctions and that society, in this sense, is an accurate reflection of biology."[79]

It was reprinted in 1996 with the addition of a new foreword and a critical review of The Bell Curve. The Mismeasure of Man has generated perhaps the greatest controversy of all of Gould's books. It has received both widespread praise[80] and extensive criticism,[81] including claims of misrepresentation.[82]

In 2011, a study conducted by six anthropologists reanalyzed Gould's claim that Samuel Morton unconsciously manipulated his skull measurements,[83] and concluded that Gould's analysis was poorly supported and incorrect. They praised Gould for his "staunch opposition to racism" but concluded, "we find that Morton's initial reputation as the objectivist of his era was well-deserved."[84] Ralph Holloway, one of the co-authors of the study, commented, "I just didn't trust Gould. ... I had the feeling that his ideological stance was supreme. When the 1996 version of 'The Mismeasure of Man' came and he never even bothered to mention Michael's study, I just felt he was a charlatan."[85] The group's paper was reviewed in the journal Nature, which recommended a degree of caution, stating "the critique leaves the majority of Gould's work unscathed," and notes that "because they couldn't measure all the skulls, they do not know whether the average cranial capacities that Morton reported represent his sample accurately."[86] The journal stated that Gould's opposition to racism may have biased his interpretation of Morton's data, but also noted that "Lewis and his colleagues have their own motivations. Several in the group have an association with the University of Pennsylvania, and have an interest in seeing the valuable but understudied skull collection freed from the stigma of bias."[86]

Non-overlapping magisterial

In his book Rocks of Ages (1999), Gould put forward what he described as "a blessedly simple and entirely conventional resolution to ... the supposed conflict between science and religion."[87] He defines the term magisterium as "a domain where one form of teaching holds the appropriate tools for meaningful discourse and resolution."[87] The non-overlapping magisteria (NOMA) principle therefore divides the magisterium of science to cover "the empirical realm: what the Universe is made of (fact) and why does it work in this way (theory). The magisterium of religion extends over questions of ultimate meaning and moral value. These two magisteria do not overlap, nor do they encompass all inquiry."[87] He suggests that "NOMA enjoys strong and fully explicit support, even from the primary cultural stereotypes of hard-line traditionalism" and that NOMA is "a sound position of general consensus, established by long struggle among people of goodwill in both magisteria."[87]

However, this view has not been without criticism. For example, in his book The God Delusion, Richard Dawkins argues that the division between religion and science is not as simple as Gould claims, as few religions exist without claiming the existence of miracles, which "by definition, violate the principles of science".[88] Dawkins also opposes the idea that religion has anything meaningful to say about ethics and values, and therefore has no authority to claim a magisterium of its own.[88] He goes on to say that he believes Gould is disingenuous in much of what he says in Rocks of Ages.[89] Similarly, humanist philosopher Paul Kurtz argues that Gould was wrong to posit that science has nothing to say about questions of ethics. In fact, Kurtz claims that science is a much better method than religion for determining moral principles.[90]

Publications

Articles

Gould's publications were numerous. One review of his publications between 1965 and 2000 noted 479 peer-reviewed papers, 22 books, 300 essays,[6] and 101 "major" book reviews.[91] A select number of his papers are listed online.

Books

The following is a list of books either written or edited by Stephen Jay Gould, including those published posthumously, after his death in 2002. While some books have been republished at later dates, by multiple publishers, the list below comprises the original publisher and publishing date.

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