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Thursday, August 9, 2018

Religious experience

From Wikipedia, the free encyclopedia

A religious experience (sometimes known as a spiritual experience, sacred experience, or mystical experience) is a subjective experience which is interpreted within a religious framework. The concept originated in the 19th century, as a defense against the growing rationalism of Western society. William James popularised the concept.

Many religious and mystical traditions see religious experiences (particularly that knowledge which comes with them) as revelations caused by divine agency rather than ordinary natural processes. They are considered real encounters with God or gods, or real contact with higher-order realities of which humans are not ordinarily aware.[3]

Skeptics may hold that religious experience is an evolved feature of the human brain amenable to normal scientific study.[note 1] The commonalities and differences between religious experiences across different cultures have enabled scholars to categorize them for academic study.[4]

Definitions

William James

Psychologist and philosopher William James described four characteristics of mystical experience in The Varieties of Religious Experience. According to James, such an experience is:
  • Transient – the experience is temporary; the individual soon returns to a "normal" frame of mind. Feels outside normal perception of space and time.
  • Ineffable – the experience cannot be adequately put into words.
  • Noetic – the individual feels that he or she has learned something valuable from the experience. Feels to have gained knowledge that is normally hidden from human understanding.
  • Passive – the experience happens to the individual, largely without conscious control. Although there are activities, such as meditation (see below), that can make religious experience more likely, it is not something that can be turned on and off at will.

Norman Habel

Norman Habel defines religious experiences as the structured way in which a believer enters into a relationship with, or gains an awareness of, the sacred within the context of a particular religious tradition (Habel, O'Donoghue and Maddox: 1993). Religious experiences are by their very nature preternatural; that is, out of the ordinary or beyond the natural order of things. They may be difficult to distinguish observationally from psychopathological states such as psychoses or other forms of altered awareness (Charlesworth: 1988). Not all preternatural experiences are considered to be religious experiences. Following Habel's definition, psychopathological states or drug-induced states of awareness are not considered to be religious experiences because they are mostly not performed within the context of a particular religious tradition.

Moore and Habel identify two classes of religious experiences: the immediate and the mediated religious experience (Moore and Habel: 1982).
  • Mediated – In the mediated experience, the believer experiences the sacred through mediators such as rituals, special persons, religious groups, totemic objects or the natural world (Habel et al.: 1993).
  • Immediate – The immediate experience comes to the believer without any intervening agency or mediator. The deity or divine is experienced directly.

Richard Swinburne

In his book Faith and Reason, the philosopher Richard Swinburne formulated five categories into which all religious experiences fall:
  • Public – a believer 'sees God's hand at work', whereas other explanations are possible e.g. looking at a beautiful sunset
  • Public – an unusual event that breaches natural law e.g. walking on water
  • Private – describable using normal language e.g. Jacob's vision of a ladder
  • Private – indescribable using normal language, usually a mystical experience e.g. "white did not cease to be white, nor black cease to be black, but black became white and white became black."
  • Private – a non-specific, general feeling of God working in one's life.
Swinburne also suggested two principles for the assessment of religious experiences:
  • Principle of Credulity – with the absence of any reason to disbelieve it, one should accept what appears to be true e.g. if one sees someone walking on water, one should believe that it is occurring.
  • Principle of Testimony – with the absence of any reason to disbelieve them, one should accept that eyewitnesses or believers are telling the truth when they testify about religious experiences.

Rudolf Otto

The German thinker Rudolf Otto (1869–1937) argues that there is one common factor to all religious experience, independent of the cultural background. In his book The Idea of the Holy (1923) he identifies this factor as the numinous. The "numinous" experience has two aspects:
  • mysterium tremendum, which is the tendency to invoke fear and trembling;
  • mysterium fascinans, the tendency to attract, fascinate and compel.
The numinous experience also has a personal quality to it, in that the person feels to be in communion with a holy other. Otto sees the numinous as the only possible religious experience. He states: "There is no religion in which it [the numinous] does not live as the real innermost core and without it no religion would be worthy of the name" (Otto: 1972). Otto does not take any other kind of religious experience such as ecstasy and enthusiasm seriously and is of the opinion that they belong to the 'vestibule of religion'.

Related terms

  • Ecstasy – In ecstasy the believer is understood to have a soul or spirit which can leave the body. In ecstasy the focus is on the soul leaving the body and to experience transcendental realities. This type of religious experience is characteristic for the shaman.
  • Enthusiasm – In enthusiasm – or possession – God is understood to be outside, other than or beyond the believer. A sacred power, being or will enters the body or mind of an individual and possesses it. A person capable of being possessed is sometimes called a medium. The deity, spirit or power uses such a person to communicate to the immanent world. Lewis argues that ecstasy and possession are basically one and the same experience, ecstasy being merely one form which possession may take. The outward manifestation of the phenomenon is the same in that shamans appear to be possessed by spirits, act as their mediums, and even though they claim to have mastery over them, can lose that mastery (Lewis: 1986).
  • Mystical experience – Mystical experiences are in many ways the opposite of numinous experiences. In the mystical experience, all 'otherness' disappear and the believer becomes one with the transcendent. The believer discovers that he or she is not distinct from the cosmos, the deity or the other reality, but one with it. Zaehner has identified two distinctively different mystical experiences: natural and religious mystical experiences (Charlesworth: 1988). Natural mystical experiences are, for example, experiences of the 'deeper self' or experiences of oneness with nature. Zaehner argues that the experiences typical of 'natural mysticism' are quite different from the experiences typical of religious mysticism (Charlesworth: 1988). Natural mystical experiences are not considered to be religious experiences because they are not linked to a particular tradition, but natural mystical experiences are spiritual experiences that can have a profound effect on the individual.
  • Spiritual awakening – A spiritual awakening usually involves a realization or opening to a sacred dimension of reality and may or may not be a religious experience. Often a spiritual awakening has lasting effects upon one's life. The term "spiritual awakening" may be used to refer to any of a wide range of experiences including being born again, near-death experiences, and mystical experiences such as liberation and enlightenment.

History

Origins

The notion of "religious experience" can be traced back to William James, who used the term "religious experience" in his book, The Varieties of Religious Experience.[5] It is considered to be the classic work in the field, and references to James' ideas are common at professional conferences. James distinguished between institutional religion and personal religion. Institutional religion refers to the religious group or organization, and plays an important part in a society's culture. Personal religion, in which the individual has mystical experience, can be experienced regardless of the culture.

The origins of the use of this term can be dated further back.[2] In the 18th, 19th, and 20th centuries, several historical figures put forth very influential views that religion and its beliefs can be grounded in experience itself. While Kant held that moral experience justified religious beliefs, John Wesley in addition to stressing individual moral exertion thought that the religious experiences in the Methodist movement (paralleling the Romantic Movement) were foundational to religious commitment as a way of life.[6]

Wayne Proudfoot traces the roots of the notion of "religious experience" to the German theologian Friedrich Schleiermacher (1768–1834), who argued that religion is based on a feeling of the infinite. The notion of "religious experience" was used by Schleiermacher and Albert Ritschl to defend religion against the growing scientific and secular critique, and defend the view that human (moral and religious) experience justifies religious beliefs.[2]

The notion of "religious experience" was adopted by many scholars of religion, of which William James was the most influential.[7][note 2]

A broad range of western and eastern movements have incorporated and influenced the emergence of the modern notion of "mystical experience", such as the Perennial philosophy, Transcendentalism, Universalism, the Theosophical Society, New Thought, Neo-Vedanta and Buddhist modernism.[11][12]

Perennial philosophy

"The Temple of the Rose Cross", Teophilus Schweighardt Constantiens, 1618.

According to the Perennial philosophy, the mystical experiences in all religions are essentially the same. It supposes that many, if not all of the world's great religions, have arisen around the teachings of mystics, including Buddha, Jesus, Lao Tze, and Krishna. It also sees most religious traditions describing fundamental mystical experience, at least esoterically. A major proponent in the 20th century was Aldous Huxley, who "was heavily influenced in his description by Vivekananda's neo-Vedanta and the idiosyncratic version of Zen exported to the west by D.T. Suzuki. Both of these thinkers expounded their versions of the perennialist thesis",[13] which they originally received from western thinkers and theologians.[14]

Transcendentalism and Unitarian Universalism

Transcendentalism was an early 19th-century liberal Protestant movement, which was rooted in English and German Romanticism, the Biblical criticism of Herder and Schleiermacher, and the skepticism of Hume.[web 1] The Transcendentalists emphasised an intuitive, experiential approach of religion.[web 2] Following Schleiermacher,[15] an individual's intuition of truth was taken as the criterion for truth.[web 2] In the late 18th and early 19th century, the first translations of Hindu texts appeared, which were also read by the Transcendentalists, and influenced their thinking.[web 2] They also endorsed universalist and Unitarianist ideas, leading to Unitarian Universalism, the idea that there must be truth in other religions as well, since a loving God would redeem all living beings, not just Christians.[web 2][web 3]

New Thought

New Thought promotes the ideas that Infinite Intelligence, or God, is everywhere, spirit is the totality of real things, true human selfhood is divine, divine thought is a force for good, sickness originates in the mind, and "right thinking" has a healing effect.[web 4][web 5] New Thought was propelled along by a number of spiritual thinkers and philosophers and emerged through a variety of religious denominations and churches, particularly the Unity Church, Religious Science, and Church of Divine Science.[16] The Home of Truth, which belongs to the New Thought movement has, from its inception as the Pacific Coast Metaphysical Bureau in the 1880s, disseminated the teachings of the Hindu teacher Swami Vivekananda.[web 6]

Theosophical Society

The Theosophical Society was formed in 1875 by Helena Blavatsky, Henry Steel Olcott, William Quan Judge and others to advance the spiritual principles and search for Truth known as Theosophy.[17][note 3] The Theosophical Society has been highly influential in promoting interest, both in west and east, in a great variety of religious teachings:
"No single organization or movement has contributed so many components to the New Age Movement as the Theosophical Society [...] It has been the major force in the dissemination of occult literature in the West in the twentieth century.[17]
The Theosophical Society searched for 'secret teachings' in Asian religions. It has been influential on modernist streams in several Asian religions, notably Hindu reform movements, the revival of Theravada Buddhism, and D.T. Suzuki, who popularized the idea of enlightenment as insight into a timeless, transcendent reality.[web 7][web 8][11] Another example can be seen in Paul Brunton's A Search in Secret India, which introduced Ramana Maharshi to a western audience.

Orientalism and the "pizza effect"

The interplay between western and eastern notions of religion is an important factor in the development of modern mysticism. In the 19th century, when Asian countries were colonialised by western states, a process of cultural mimesis began.[14][18][2] In this process, Western ideas about religion, especially the notion of "religious experience" were introduced to Asian countries by missionaries, scholars and the Theosophical Society, and amalgamated in a new understanding of the Indian and Buddhist traditions. This amalgam was exported back to the West as 'authentic Asian traditions', and acquired a great popularity in the west. Due to this western popularity, it also gained authority back in India, Sri Lanka and Japan.[14][18][2]
The best-known representatives of this amalgamated tradition are Annie Besant (Theosophical Society), Swami Vivekenanda and Sarvepalli Radhakrishnan (Neo-Vedanta), Anagarika Dharmapala, a 19th-century Sri Lankan Buddhist activist who founded the Maha Bodhi Society, and D.T. Suzuki, a Japanese scholar and Zen-Buddhist. A synonymous term for this broad understanding is nondualism. This mutual influence is also known as the pizza effect.

Criticism

The notion of "experience" has been criticised.[19][20][21]

"Religious empiricism" is seen as highly problematic and was – during the period in-between world wars – famously rejected by Karl Barth.[22] In the 20th century, religious as well as moral experience as justification for religious beliefs still holds sway. Some influential modern scholars holding this liberal theological view are Charles Raven and the Oxford physicist/theologian Charles Coulson.[23]

Robert Sharf points out that "experience" is a typical Western term, which has found its way into Asian religiosity via western influences.[19][note 4] The notion of "experience" introduces a false notion of duality between "experiencer" and "experienced", whereas the essence of kensho is the realisation of the "non-duality" of observer and observed.[25][26] "Pure experience" does not exist; all experience is mediated by intellectual and cognitive activity.[27][28] The specific teachings and practices of a specific tradition may even determine what "experience" someone has, which means that this "experience" is not the proof of the teaching, but a result of the teaching.[1] A pure consciousness without concepts, reached by "cleansing the doors of perception",[note 5] would be an overwhelming chaos of sensory input without coherence.[30]

Causes of religious experiences

Religious practices: traditions offer a wide variety of religious practices to induce religious experiences:
Drugs: religious experiences may also be caused by the use of entheogens, such as:
Neurophysiological origins: Religious experiences may have neurophysiological origins. These are studied in the field of neurotheology, and the cognitive science of religion, and include near-death experience[42] and the "Koren helmet"[43] Causes may be:

Religious practices

Western

Neoplatonism

Neoplatonism is the modern term for a school of religious and mystical philosophy that took shape in the 3rd century AD, founded by Plotinus and based on the teachings of Plato and earlier Platonists.
Neoplatonism teaches that along the same road by which it descended the soul must retrace its steps back to the supreme Good. It must first of all return to itself. This is accomplished by the practice of virtue, which aims at likeness to God, and leads up to God. By means of ascetic observances the human becomes once more a spiritual and enduring being, free from all sin. But there is still a higher attainment; it is not enough to be sinless, one must become "God", (henosis). This is reached through contemplation of the primeval Being, the One – in other words, through an ecstatic approach to it.

It is only in a state of perfect passivity and repose that the soul can recognize and touch the primeval Being. Hence the soul must first pass through a spiritual curriculum. Beginning with the contemplation of corporeal things in their multiplicity and harmony, it then retires upon itself and withdraws into the depths of its own being, rising thence to the nous, the world of ideas. But even there it does not find the Highest, the One; it still hears a voice saying, "not we have made ourselves." The last stage is reached when, in the highest tension and concentration, beholding in silence and utter forgetfulness of all things, it is able as it were to lose itself. Then it may see God, the foundation of life, the source of being, the origin of all good, the root of the soul. In that moment it enjoys the highest indescribable bliss; it is as it were swallowed up of divinity, bathed in the light of eternity. Porphyry tells us that on four occasions during the six years of their intercourse Plotinus attained to this ecstatic union with God.

Alcoholics Anonymous Twelfth Step

The twelfth step of the Alcoholics Anonymous program states that "Having had a spiritual awakening as the result of these steps, we tried to carry this message to alcoholics and to practice these principles in all our affairs".[47] The terms “spiritual experience” and “spiritual awaken-ing” are used many times in "The Big Book of Alcoholics Anonymous"[48] which argues that a spiritual experience is needed to bring about recovery from alcoholism.[49]

Christianity

Christian mysticism
Three early Methodist leaders, Charles Wesley, John Wesley, and Francis Asbury, portrayed in stained glass at the Memorial Chapel, Lake Junaluska, North Carolina

Christian doctrine generally maintains that God dwells in all Christians and that they can experience God directly through belief in Jesus,[50] Christian mysticism aspires to apprehend spiritual truths inaccessible through intellectual means, typically by emulation of Christ. William Inge divides this scala perfectionis into three stages: the "purgative" or ascetic stage, the "illuminative" or contemplative stage, and the third, "unitive" stage, in which God may be beheld "face to face."[51]

The third stage, usually called contemplation in the Western tradition, refers to the experience of oneself as united with God in some way. The experience of union varies, but it is first and foremost always associated with a reuniting with Divine love. The underlying theme here is that God, the perfect goodness,[52] is known or experienced at least as much by the heart as by the intellect since, in the words of 1 John 4:16: "God is love, and he who abides in love abides in God and God in him." Some approaches to classical mysticism would consider the first two phases as preparatory to the third, explicitly mystical experience; but others state that these three phases overlap and intertwine.
Hesychasm
Based on Christ's injunction in the Gospel of Matthew to "go into your closet to pray",[53] hesychasm in tradition has been the process of retiring inward by ceasing to register the senses, in order to achieve an experiential knowledge of God (see theoria).

The highest goal of the hesychast is the experiential knowledge of God. In the 14th Century, the possibility of this experiential knowledge of God was challenged by a Calabrian monk, Barlaam, who, although he was formally a member of the Orthodox Church, had been trained in Western Scholastic theology. Barlaam asserted that our knowledge of God can only be propositional. The practice of the hesychasts was defended by St. Gregory Palamas.

Islam

While all Muslims believe that they are on the pathway to God and will become close to God in Paradise – after death and after the "Final Judgment" – Sufis believe that it is possible to become close to God and to experience this closeness while one is alive.[54] Sufis believe in a tripartite way to God as explained by a tradition attributed to the Prophet,"The Shariah are my words (aqwal), the tariqa are my actions (amal), and the haqiqa is my interior states (ahwal)". Shariah, tariqa and haqiqa are mutually interdependent.

The tariqa, the ‘path’ on which the mystics walk, has been defined as ‘the path which comes out of the Shariah, for the main road is called shar, the path, tariq.’ No mystical experience can be realized if the binding injunctions of the Shariah are not followed faithfully first. The path, tariqa, however, is narrower and more difficult to walk. It leads the adept, called salik (wayfarer), in his suluk (wandering), through different stations (maqam) until he reaches his goal, the perfect tauhid, the existential confession that God is One.[55]

Asia

Buddhism

The Buddha demonstrating control over fire and water. Gandhara, 3rd century CE

In Theravada Buddhism practice is described in the threefold training of discipline (śīla), meditative concentration (samādhi), and transcendent wisdom (prajñā). Zen-Buddhism emphaises the sole practice of meditation, while Vajrayana Buddhism utilizes a wide variety of practices. While the main aim of meditation and prajna is to let go of attachments, it may also result in a comprehension of the Buddha-nature and the inherent lucidness of the mind.

Different varieties of religious experience are described in detail in the Śūraṅgama Sūtra. In its section on the fifty skandha-maras, each of the five skandhas has ten skandha-maras associated with it, and each skandha-mara is described in detail as a deviation from correct samādhi. These skandha-maras are also known as the "fifty skandha demons" in some English-language publications.[56]

It is also believed that supernormal abilities are developed from meditation, which are termed "higher knowledge" (abhijñā), or "spiritual power" (ṛddhi). One early description found in the Samyutta Nikaya, which mentions abilities such as:[57]
... he goes unhindered through a wall, through a rampart, through a mountain as though through space; he dives in and out of the earth as though it were water; he walks on water without sinking as though it were earth; seated cross-legged, he travels in space like a bird; with his hands he touches and strokes the moon and sun so powerful and mighty; he exercises mastery with the body as far as the brahmā world.

Hinduism

Building on European philosophers, Radhakrishnan reduced religion "to the core experience of reality in its fundamental unity". [58] According to Sarvepalli Radhakrishnan, "Hinduism is not just a faith. It is the union of reason and intuition that cannot be defined, but is only to be experienced."[59] This emphasis on experience as validation of a religious worldview is a modern development, which started in the 19th century, and was introduced to Indian thought by western Unitarian missionaries.[12] It has been popularized in Neo-Vedanta, which has dominated the popular understanding of Hinduism since the 19th century.[60][note 6] It emphasizes mysticism.[60][61][62][63] Swami Vivekanada presented the teachings of Neo-Vedanta as radical nondualism, unity between all religions and all persons.[64][65]

Meher Baba

According to the syncretistic Indian spiritual teacher Meher Baba, "Spiritual experience involves more than can be grasped by mere intellect. This is often emphasised by calling it a mystical experience. Mysticism is often regarded as something anti-intellectual, obscure and confused, or impractical and unconnected with experience. In fact, true mysticism is none of these. There is nothing irrational in true mysticism when it is, as it should be, a vision of Reality. It is a form of perception which is absolutely unclouded, and so practical that it can be lived every moment of life and expressed in every-day duties. Its connection with experience is so deep that, in one sense, it is the final understanding of all experience."[66]

Psychedelic drugs

Dr. R.R. Griffiths and colleagues at Johns Hopkins University had done a double blind study evaluating the psychological effects of psilocybin comparing with methylphenidate(Ritalin). 36 hallucinogen-naive adults were recruited. 22 of the 36 reported mystical experience. The effect persisted even at 2 and 14 months follow-up.[67][68] The group continued to do studies in evaluating the effect with different dosing[69] and the resulting mystical effect on personality.[70]

Neurophysiology

Psychiatry

A 2012 paper suggested that psychiatric conditions associated with psychotic spectrum symptoms may be possible explanations for revelatory driven experiences and activities such as those of Abraham, Moses, Jesus and Saint Paul.[71]

Neuroscience

Neuroscience of religion

Neuroscience of religion, also known as neurotheology, biotheology or spiritual neuroscience,[72] is the study of correlations of neural phenomena with subjective experiences of spirituality and hypotheses to explain these phenomena. Proponents of neurotheology claim that there is a neurological and evolutionary basis for subjective experiences traditionally categorized as spiritual or religious.[73]
The neuroscience of religion takes neural correlates as the basis of cognitive functions and religious experiences. These religious experience are thereby emergent properties of neural correlates. This approach does not necessitate exclusion of the Self, but interprets the Self as influenced or otherwise acted upon by underlying neural mechanisms. Proponents argue that religious experience can be evoked through stimulus of specific brain regions and/or can be observed through measuring increase in activity of specific brain regions.[74][note 7]

An alternate approach is influenced by personalism, and exists contra-parallel to the reductionist approach. It focuses on the Self as the object of interest,[note 8] the same object of interest as in religion.[citation needed] According to Patrick McNamara, a proponent of personalism, the Self is a neural entity that controls rather than consists of the cognitive functions being processed in brain regions.[78][79][note 9]

Neurological evolutionary basis

A biological basis for religious experience may exist.[80][79] References to the supernatural or mythical beings first appeared approximately 40,000 years ago.[81][82] A popular theory posits that dopaminergic brain systems are the evolutionary basis for human intellect[83][82] and more specifically abstract reasoning.[82] The capacity for religious thought arises from the capability to employ abstract reasoning. There is no evidence to support the theory that abstract reasoning, generally or with regard to religious thought, evolved independent of the dopaminergic axis.[82]

Religious behavior has been linked to "extrapersonal brain systems that predominate the ventromedial cortex and rely heavily on dopaminergic transmission."[84] A biphasic effect exists with regard to activation of the dopaminergic axis and/or ventromedial cortex. While mild activation can evoke a perceived understanding of the supernatural, extreme activation can lead to delusions characteristic of psychopathy.[82] Stress can cause the depletion of 5-hydroxytryptamine, also referred to as serotonin.[85] The ventromedial 5-HT axis is involved in peripersonal activities such as emotional arousal, social skills, and visual feedback.[82] When 5-HT is decreased or depleted, one may become subject to "incorrect attributions of self-initiated or internally generated activity (e.g. hallucinations)."[86]

Studies of the brain

Early studies in the 1950s and 1960s attempted to use EEGs to study brain wave patterns correlated with spiritual states. During the 1980s Dr. Michael Persinger stimulated the temporal lobes of human subjects[87] with a weak magnetic field. His subjects claimed to have a sensation of "an ethereal presence in the room."[88] Some current studies use neuroimaging to localize brain regions active, or differentially active, during religious experiences.[89][90][91] These neuroimaging studies have implicated a number of brain regions, including the limbic system, dorsolateral prefrontal cortex, superior parietal lobe, and caudate nucleus.[92][93][94] Based on the complex nature of religious experience, it is likely that they are mediated by an interaction of neural mechanisms that all add a small piece to the overall experience.[93]

According to the neurotheologist Andrew B. Newberg, neurological processes which are driven by the repetitive, rhythmic stimulation which is typical of human ritual, and which contribute to the delivery of transcendental feelings of connection to a universal unity.[clarification needed] They posit, however, that physical stimulation alone is not sufficient to generate transcendental unitive experiences. For this to occur they say there must be a blending of the rhythmic stimulation with ideas. Once this occurs "...ritual turns a meaningful idea into a visceral experience."[95] Moreover, they say that humans are compelled to act out myths by the biological operations of the brain due to what they call the "inbuilt tendency of the brain to turn thoughts into actions."

Temporal lobe epilepsy

Temporal lobe epilepsy has become a popular field of study due to its correlation to religious experience.[96][97][98][99] Religious experiences and hyperreligiosity are often used to characterize those with Temporal Lobe Epilepsy.[100][101] Visionary religious experiences, and momentary lapses of consciousness, may point toward a diagnosis of Geschwind syndrome. More generally, the symptoms are consistent with features of Temporal Lobe Epilepsy, not an uncommon feature in religious icons and mystics.[102] It seems that this phenomenon is not exclusive to TLE, but can manifest in the presence of other epileptic variates[103][104][82] as well as mania, obsessive-compulsive disorder, and schizophrenia, conditions characterized by ventromedial dopaminergic dysfunction.[82]

Integrating religious experience

Several psychologists have proposed models in which religious experiences are part of a process of transformation of the self.
Carl Jung's work on himself and his patients convinced him that life has a spiritual purpose beyond material goals. One's main task, he believed, is to discover and fulfil deep innate potential, much as the acorn contains the potential to become the oak, or the caterpillar to become the butterfly. Based on his study of Christianity, Hinduism, Buddhism, Gnosticism, Taoism, and other traditions, Jung perceived that this journey of transformation is at the mystical heart of all religions. It is a journey to meet the self and at the same time to meet the Divine. Unlike Sigmund Freud, Jung thought spiritual experience was essential to well-being.[105]

The notion of the numinous was an important concept in the writings of Carl Jung. Jung regarded numinous experiences as fundamental to an understanding of the individuation process because of their association with experiences of synchronicity in which the presence of archetypes is felt.[106][107]

McNamara proposes that religious experiences may help in "decentering" the self, and transform it into an integral self which is closer to an ideal self.[108]

Transpersonal psychology is a school of psychology that studies the transpersonal, self-transcendent or spiritual aspects of the human experience. The Journal of Transpersonal Psychology describes transpersonal psychology as "the study of humanity’s highest potential, and with the recognition, understanding, and realization of unitive, spiritual, and transcendent states of consciousness" (Lajoie and Shapiro, 1992:91). Issues considered in transpersonal psychology include spiritual self-development, peak experiences, mystical experiences, systemic trance and other metaphysical experiences of living.

Temporal lobe epilepsy

From Wikipedia, the free encyclopedia
Temporal lobe epilepsy (TLE)
Lobes of the brain NL.svg
Lobes of the brain. Temporal lobe in green
Classification and external resources
SpecialtyPsychiatry, Neurology
ICD-10G40.1-G40.2
ICD-9-CM345.4
DiseasesDB29433
MedlinePlus001399
eMedicineneuro/365
Patient UKTemporal lobe epilepsy
MeSHD004833

Temporal lobe epilepsy (TLE) is a chronic disorder of the nervous system characterized by recurrent, unprovoked focal seizures that originate in the temporal lobe of the brain and last about one or two minutes. TLE is the most common form of epilepsy with focal seizures. A focal seizure in the temporal lobe may spread to other areas in the brain when it may become a focal to bilateral seizure.

TLE is usually diagnosed in childhood or adolescence. TLE is diagnosed by taking a medical history, blood tests, and brain imaging. It can have a number of causes such as head injury, stroke, brain infections, structural lesions in the brain, or brain tumors, or it can be of unknown onset. The first line of treatment is through anticonvulsants. Surgery may be an option, especially when there is an observable abnormality in the brain. Another treatment option is electrical stimulation of the brain through an implanted device called the vagus nerve stimulator (VNS).[1]

Types

Over forty types of epilepsy are recognized and these are divided into two main groups: focal seizures and generalized seizures.[2] Focal seizures account for approximately sixty percent of all adult cases.[3] Temporal lobe epilepsy (TLE) is the single most common form of focal seizure.[4]

The International League Against Epilepsy (ILAE) recognizes two main types of temporal lobe epilepsy: mesial temporal lobe epilepsy (MTLE), arising in the hippocampus, the parahippocampal gyrus and the amygdala which are located in the inner (medial) aspect of the temporal lobe and lateral temporal lobe epilepsy (LTLE), the rarer type, arising in the neocortex at the outer (lateral) surface of the temporal lobe.[3] The seizures of LTLE are characterized by auditory or visual features. Autosomal dominant lateral temporal lobe epilepsy (ADLTLE) is a rare hereditary condition, often associated with mutations in the LGI1 gene.[5]

Signs and symptoms

When a seizure begins in the temporal lobe, its effects depend on the precise location of its point of origin, its locus. In 1981, the ILAE recognized three types of seizures occurring in temporal lobe epilepsy. The classification was based on EEG findings.[6] However as of 2017 the general classification of seizures has been revised.[7] The newer classification uses three key features: where the seizures begin, the level of awareness during a seizure, and other features.[7]

Focal seizures

MRI Location amygdala
Focal seizures in the temporal lobe involve small areas of the lobe such as the amygdala and hippocampus.

The newer classification gives two types of focal onset seizures, as focal aware and focal impaired awareness.[2]

Focal aware seizures

Focal aware means that the level of consciousness is not altered during the seizure.[2] In temporal lobe epilepsy, a focal seizure usually causes abnormal sensations only.
These may be:
  • Sensations such as déjà vu (a feeling of familiarity), jamais vu (a feeling of unfamiliarity)
  • Amnesia; or a single memory or set of memories
  • A sudden sense of unprovoked fear and anxiety
  • Nausea
  • Auditory, visual, olfactory, gustatory, or tactile hallucinations.
  • Visual distortions such as macropsia and micropsia
  • Dissociation or derealisation
  • Synesthesia (stimulation of one sense experienced in a second sense) may transpire.[8]
  • Dysphoric or euphoric feelings, fear, anger, and other emotions may also occur. Often, the patient cannot describe the sensations.[9]
Olfactory hallucinations often seem indescribable to patients beyond "pleasant" or "unpleasant".[10]

Focal aware seizures are often called "auras" when they serve as a warning sign of a subsequent seizure. Regardless an aura is actually a seizure itself, and such a focal seizure may or may not progress to a focal impaired awareness seizure.[11] People who only experience focal aware seizures may not recognize what they are, nor seek medical care.

Focal impaired awareness seizures

Focal impaired awareness seizures are seizures which impair consciousness to some extent:[2] they alter the person's ability to interact normally with their environment. They usually begin with a focal aware seizure, then spread to a larger portion of the temporal lobe, resulting in impaired consciousness. They may include autonomic and psychic features present in focal aware seizures.

Signs may include:[12]
  • Motionless staring
  • Automatic movements of the hands or mouth
  • Confusion and disorientation
  • Altered ability to respond to others, unusual speech
  • Transient aphasia (losing ability to speak, read, or comprehend spoken word)
These seizures tend to have a warning or aura before they occur, and when they occur they generally tend to last only 1–2 minutes. It is not uncommon for an individual to be tired or confused for up to 15 minutes after a seizure has occurred, although postictal confusion can last for hours or even days. Though they may not seem harmful, due to the fact that the individual does not normally seize, they can be extremely harmful if the individual is left alone around dangerous objects. For example, if a person with complex partial seizures is driving alone, this can cause them to run into the ditch, or worse, cause an accident involving multiple people. With this type, some people do not even realize they are having a seizure and most of the time their memory from right before or after the seizure is wiped. First-aid is only required if there has been an injury or if this is the first time a person has had a seizure.

Focal to bilateral seizures

Seizures which begin in the temporal lobe, and then spread to involve both sides of the brain are termed focal to bilateral. (Where both sides of the brain or the whole brain are involved from the onset the seizures are known as generalized seizures and may be tonic clonic.[7] The arms, trunk, and legs stiffen (the tonic phase), in either a flexed or extended position, and then jerk (the clonic phase). These were previously known as grand mal seizures.[12] The word grand mal comes from the French term, meaning major affliction.[citation needed]

Postictal period

There is some period of recovery in which neurological function is altered after each of these seizure types. This is the postictal state. The degree and length of postictal impairment directly correlates with the severity of the seizure type. Focal aware seizures often last less than sixty seconds; focal with impaired awareness seizures may last up to two minutes; and generalized tonic clonic seizures may last up to three minutes.[citation needed] The postictal state in seizures other than focal aware may last much longer than the seizure itself.

Because a major function of the temporal lobe is short-term memory, a focal with impaired awareness seizure, and a focal to bilateral seizure can cause amnesia for the period of the seizure, meaning that the seizure may not be remembered.[citation needed]

Complications and prognosis

Depression

Individuals with temporal lobe epilepsy have a higher prevalence of depression than the general population. Although the psychosocial impacts of epilepsy may be causative, there are also links in the phenomenology and neurobiology of TLE and depression.[13]

Memory

Hippocampus

The temporal lobe and particularly the hippocampus plays an important role in memory processing. Declarative memory (memories which can be consciously recalled) is formed in the area of the hippocampus called the dentate gyrus.[citation needed]

Temporal lobe epilepsy is associated with memory disorders and loss of memory. Animal models and clinical studies show that memory loss correlates with temporal lobe neuronal loss in temporal lobe epilepsy. Verbal memory deficit correlates with pyramidal cell loss in TLE. This is more so on the left in verbal memory loss. Neuronal loss on the right is more prominent in non-verbal (visuospatial memory loss).[14][15][16][17][18]

Childhood onset

After childhood onset, one third will "grow out" of TLE, finding a lasting remission up to an average of 20 years. The finding of a lesion such as hippocampal sclerosis (a scar in the hippocampus), tumour, or dysplasia, on magnetic resonance imaging (MRI) predicts the intractability of seizures.[19]

Personality

The effect of temporal lobe epilepsy on personality is an historical observation dating to the 1800s. Personality and behavioural change in temporal lobe epilepsy is seen as a chronic condition when it persists for more than three months.[20]

Geschwind syndrome is a set of behavioural phenomena seen in some people with TLE. Documented by Norman Geschwind, signs include: hypergraphia (compulsion to write (or draw) excessively), hyperreligiosity (intense religious or philosophical experiences or interests), hyposexuality (reduced sexual interest or drive), circumstantiality (result of a non-linear thought pattern, talks at length about irrelevant and trivial details).[21] The personality changes generally vary by hemisphere.[21]

The existence of a "temporal lobe epileptic personality" and Geschwind syndrome has been disputed and research is inconclusive.[21]

Diagnosis

Epileptic spike and wave discharges monitored with EEG

The diagnosis of temporal lobe epilepsy can include the following methods:[22] Magnetic resonance imaging (MRI), CT scans, positron emission tomography (PET), EEG, and magnetoencephalography.

Differential diagnosis

Other medical conditions with similar symptoms include panic attacks, psychosis spectrum disorders, tardive dyskinesia, and occipital lobe epilepsy.[23]

Causes

The causes of TLE include mesial temporal sclerosis, traumatic brain injury, brain infections, such as encephalitis and meningitis, hypoxic brain injury, stroke, cerebral tumours, and genetic syndromes. Temporal lobe epilepsy is not the result of psychiatric illness or fragility of the personality.[12]

Febrile seizures

Although the theory is controversial, there is a link between febrile seizures (seizures coinciding with episodes of fever in young children) and subsequent temporal lobe epilepsy, at least epidemiologically.[24][25][26][27]

Human herpes virus 6

Reelin

In the mid 1980s, human herpesvirus 6 (HHV-6) was suggested as a possible causal link between febrile convulsions and mesial temporal lobe epilepsy. However, although the virus is found in temporal lobe tissue at surgery for TLE, it has not been recognised as a major factor in febrile seizures or TLE.[28][29][30]

Reelin

Dispersion of the granule cell layer in the hippocampal dentate gyrus is occasionally seen in temporal lobe epilepsy and has been linked to the downregulation of reelin, a protein that normally keeps the layer compact by containing neuronal migration. It is unknown whether changes in reelin expression play a role in epilepsy.[31][32]

Pathophysiology

Neuronal loss

In TLE, there is loss of neurons in region CA1 and CA3 of the hippocampus.[33][34] There is also damage to mossy cells and inhibitory interneurons in the hilar region of the hippocampus (region IV) and to the granule cells of the dentate gyrus. In animal models, neuronal loss occurs during seizures but in humans, neuronal loss predates the first seizure and does not necessarily continue with seizure activity.[35][36][37][38][39] The loss of the GABA-mediated inhibitory interneurons may increase the hyperexcitability of neurons of the hippocampus leading to recurrent seizures.[40] According to the "dormant basket cell" hypothesis, mossy cells normally excite basket cells which in turn, inhibit granule cells. Loss of mossy cells lowers the threshold of action potentials of the granule cells.[41]

GABA reversal

In certain patients with temporal lobe epilepsy it has been found that the subiculum could generate epileptic activity. It has been found that GABA reversal potential is depolarising[42] in the subpopulation of the pyramidal cells due to the lack of KCC2 co-transporter. It has been shown that it is theoretically possible to generate seizures in the neural networks due to down-regulation of KCC2,[43] consistent with the chloride measurements during the transition to seizure[44] and KCC2 blockade experiments.[45]

Granule cell dispersion in the dentate gyrus

Granule cell dispersion is a type of developmental migration and a pathological change found in the TLE brain which was first described in 1990.[46][47] The granule cells of the dentate gyrus are tightly packed forming a uniform, laminated layer with no monosynaptic connections.[48] This structure provides a filter for the excitability of neurons.[48]

In TLE, granule cells are lost, the structure is no longer closely packed and there are changes in the orientation of dendrites.[47][49] These changes may or may not be epileptogenic. For instance, if the dendrites of granule cells reconnect, it may be in a way (through the laminar planes) that allows hyperexcitability.[36] However, not all patients have granule cell dispersion.[33](p387–389)

Aberrant mossy fiber sprouting

Mossy fibers are the axons of granule cells. They project into the hilus of the dentate gyrus and stratum lucidum in the CA3 region giving inputs to both excitatory and inhibitory neurons.[48][50][51]

In the TLE brain, where granule cells are damaged or lost, axons, the mossy fibres, 'sprout' in order to reconnect to other granule cell dendrites. This is an example of synaptic reorganization. This was noted in human tissue in 1974 and in animal models in 1985. In TLE, the sprouting mossy fibres are larger than in the normal brain and their connections may be aberrant. Mossy fibre sprouting continues from one week to two months after injury.[33](p416–431)[48][52][53][54]

Aberrant mossy fibre sprouting may create excitatory feedback circuits that lead to temporal lobe seizures. This is evident in intracellular recordings.[55] Stimulation of aberrant mossy fibre areas increases the excitatory postsynaptic potential response.[56][57]

However, aberrant mossy fiber sprouting may inhibit excitatory transmission by synapsing with basket cells which are inhibitory neurons and by releasing GABA and neuropeptide Y which are inhibitory neurotransmitters. Also, in animal models, granule cell hyper-excitability is recorded before aberrant mossy fibre sprouting has occurred.[58][59][60][61]

Treatments

Anticonvulsants

Many anticonvulsant oral medications are available for the management of temporal lobe seizures. Most anticonvulsants function by decreasing the excitation of neurons, for example, by blocking fast or slow sodium channels or by modulating calcium channels; or by enhancing the inhibition of neurons, for example by potentiating the effects of inhibitory neurotransmitters like GABA.[citation needed]

In TLE, the most commonly used older medications are phenytoin, carbamazepine, primidone, valproate, and phenobarbital. Newer drugs, such as gabapentin, topiramate, levetiracetam, lamotrigine, pregabalin, tiagabine, lacosamide, and zonisamide promise similar effectiveness, with possibly fewer side-effects. Felbamate and vigabatrin are newer, but can have serious adverse effects so they are not considered as first-line treatments.

Up to one third of patients with medial temporal lobe epilepsy will not have adequate seizure control with medication alone. For patients with medial TLE whose seizures remain uncontrolled after trials of several types of anticonvulsants (that is, the epilepsy is intractable), surgical excision of the affected temporal lobe may be considered.[62]

Surgical interventions

Epilepsy surgery has been performed since the 1860s and doctors have observed that it is highly effective in producing freedom from seizures. However, it was not until 2001 that a scientifically sound study was carried out to examine the effectiveness of temporal lobectomy.[63]
Temporal lobe surgery can be complicated by decreased cognitive function. However, after temporal lobectomy, memory function is supported by the opposite temporal lobe; and recruitment of the frontal lobe.[64][65] Cognitive rehabilitation may also help.[66]

Other treatments

Where surgery is not recommended, further management options include new (including experimental) anticonvulsants, and vagus nerve stimulation. The ketogenic diet is also recommended for children, and some adults.[67] Other options include brain cortex responsive neural stimulators, deep brain stimulation, stereotactic radiosurgery, such as the gamma knife, and laser ablation.[68]

Link with religiosity

The first to record and catalog the abnormal symptoms and signs of TLE was Norman Geschwind. He found a constellation of symptoms that included hypergraphia, hyperreligiosity, collapse, and pedantism, now called Geschwind syndrome.

Vilayanur S. Ramachandran explored the neural basis of the hyperreligiosity seen in TLE using the galvanic skin response (GSR), which correlates with emotional arousal, to determine whether the hyperreligiosity seen in TLE was due to an overall heightened emotional state or was specific to religious stimuli. Ramachandran presented two subjects with neutral, sexually arousing and religious words while measuring GSR. Ramachandran was able to show that patients with TLE showed enhanced emotional responses to the religious words, diminished responses to the sexually charged words, and normal responses to the neutral words. This study was presented as an abstract at a neuroscience conference and referenced in Ramachandran's book, Phantoms in the Brain,[69] but it has never been published in the peer-reviewed scientific press.[70]

A study in 2015, reported that intrinsic religiosity and religiosity outside of organized religion were higher in patients with epilepsy than in controls.[71] Lower education level, abnormal background EEG activity, and hippocampal sclerosis have been found to be contributing factors for religiosity in Temporal Lobe Epilepsy.[72]

Temporal lobe epilepsy has been suggested as a physical explanation for the revelatory experiences of prominent religious figures such as Abraham, Moses, Jesus, Mohammed, Saint Paul, and Joseph Smith. These experiences are described as complex interactions with their visions, but lacking the stereotypy, amnestic periods, and automatisms or generalized motor events, which are characteristic of TLE. Psychiatric conditions with psychotic spectrum symptoms may be a more plausible physical explanation of these experiences.[73] Pope Pius IX's doctrine of the immaculate conception is thought to have been influenced by his forensically diagnosed partial epilepsy.[74] It has also been suggested that the visions of Joan of Arc were probably an expression of partial epilepsy.[75] In 2016, a case history found that a temporal lobe epileptic experienced a vision of God following a temporal lobe seizure, while undergoing EEG monitoring. The patient reported that God had sent him to the world to "bring redemption to the people of Israel".[76] The purported link between TLE and religiosity has inspired work by Michael Persinger and many other researchers in the field of neurotheology, but some have questioned the evidence for a link between temporal lobe epilepsy and religiosity.[70][77] The novel, Lying Awake, by Mark Salzman, deals with topic of temporal lobe epilepsy and religion.

Neuroscience of religion

From Wikipedia, the free encyclopedia

The neuroscience of religion, also known as neurotheology and as spiritual neuroscience, attempts to explain religious experience and behaviour in neuroscientific terms. It is the study of correlations of neural phenomena with subjective experiences of spirituality and hypotheses to explain these phenomena. This contrasts with the psychology of religion which studies mental, rather than neural, states.

Proponents of the neuroscience of religion say there is a neurological and evolutionary basis for subjective experiences traditionally categorized as spiritual or religious.[3] The field has formed the basis of several popular science books,[4][5][6] but has received criticism from psychologists.[2]

Introduction

"Neurotheology" is a neologism that describes the scientific study of the neural correlates of religious or spiritual beliefs, experiences and practices. Other researchers prefer to use terms like "spiritual neuroscience" or "neuroscience of religion". Researchers in the field attempt to explain the neurological basis for religious experiences, such as:[7]

Terminology

Aldous Huxley used the term neurotheology for the first time in the utopian novel Island. The discipline studies the cognitive neuroscience of religious experience and spirituality. The term is also sometimes used in a less scientific context or a philosophical context. Some of these uses, according to the mainstream scientific community, qualify as pseudoscience. Huxley used it mainly in a philosophical context.

The use of the term neurotheology in published scientific work is currently uncommon. A search on the citation indexing service provided by Institute for Scientific Information returns five articles. Three of these are published in the journal Zygon: Journal of Religion & Science, while two are published in American Behavioral Scientist. Work on the neural basis of spirituality has, however, occurred sporadically throughout the 20th century.

Theoretical work

In an attempt to focus and clarify what was a growing interest in this field, in 1994 educator and businessman Laurence O. McKinney published the first book on the subject, titled "Neurotheology: Virtual Religion in the 21st Century", written for a popular audience but also promoted in the theological journal Zygon.[9] According to McKinney, neurotheology sources the basis of religious inquiry in relatively recent developmental neurophysiology. According to McKinney's theory, pre-frontal development, in humans, creates an illusion of chronological time as a fundamental part of normal adult cognition past the age of three. The inability of the adult brain to retrieve earlier images experienced by an infantile brain creates questions such as "where did I come from" and "where does it all go", which McKinney suggests led to the creation of various religious explanations. The experience of death as a peaceful regression into timelessness as the brain dies won praise from readers as varied as author Arthur C. Clarke, eminent theologian Harvey Cox, and the Dalai Lama and sparked a new interest in the field.[citation needed]

What Andrew B. Newberg and others "discovered is that intensely focused spiritual contemplation triggers an alteration in the activity of the brain that leads one to perceive transcendent religious experiences as solid, tangible reality. In other words, the sensation that Buddhists call oneness with the universe."[10] The orientation area requires sensory input to do its calculus. "If you block sensory inputs to this region, as you do during the intense concentration of meditation, you prevent the brain from forming the distinction between self and not-self," says Newberg. With no information from the senses arriving, the left orientation area cannot find any boundary between the self and the world. As a result, the brain seems to have no choice but "to perceive the self as endless and intimately interwoven with everyone and everything." "The right orientation area, equally bereft of sensory data, defaults to a feeling of infinite space. The meditators feel that they have touched infinity."[11]

The radical Catholic theologian Eugen Drewermann developed a two-volume critique of traditional conceptions of God and the soul and a reinterpretation of religion (Modern Neurology and the Question of God) based on current neuroscientific research.[12]

However, it has also been argued "that neurotheology should be conceived and practiced within a theological framework."[13] Furthermore, it has been suggested that creating a separate category for this kind of research is moot since conventional Behavioural and Social Neurosciences disciplines can handle any empirical investigation of this nature.[14]

Various theories regarding the evolutionary origin of religion and the evolutionary psychology of religion have been proposed.

Experimental work

In 1969, British biologist Alister Hardy founded a Religious Experience Research Centre at Oxford after retiring from his post as Linacre Professor of Zoology. Citing William James's The Varieties of Religious Experience (1902), he set out to collect first-hand accounts of numinous experiences. He was awarded the Templeton Prize before his death in 1985. His successor David Hay suggested in God’s Biologist: A life of Alister Hardy (2011) that the RERC later dispersed as investigators turned to newer techniques of scientific investigation.

Magnetic stimulation studies

During the 1980s Michael Persinger stimulated the temporal lobes of human subjects with a weak magnetic field using an apparatus that popularly became known as the "God helmet"[15] and reported that many of his subjects claimed to experience a "sensed presence" during stimulation.[16] This work has been criticised,[2][17][18] though some researchers [19] have published a replication of one God Helmet experiment.[20]

Granqvist et al. claimed that Persinger's work was not "double-blind." Participants were often graduate students who knew what sort of results to expect, and there was the risk that the experimenters' expectations would be transmitted to subjects by unconscious cues. The participants were frequently given an idea of the purpose of the study by being asked to fill in questionnaires designed to test their suggestibility to paranormal experiences before the trials were conducted. Granqvist et al. failed to replicate Persinger's experiments double-blinded, and concluded that the presence or absence of the magnetic field had no relationship with any religious or spiritual experience reported by the participants, but was predicted entirely by their suggestibility and personality traits. Following the publication of this study, Persinger et al. dispute this.[21] One published attempt to create a "haunted room" using environmental "complex" electromagnetic fields based on Persinger's theoretical and experimental work did not produce the sensation of a "sensed presence" and found that reports of unusual experiences were uncorrelated with the presence or absence of these fields. As in the study by Granqvist et al., reports of unusual experiences were instead predicted by the personality characteristics and suggestibility of participants.[22] One experiment with a commercial version of the God helmet found no difference in response to graphic images whether the device was on or off.[23][24]

Neuropsychology and neuroimaging

The first researcher to note and catalog the abnormal experiences associated with temporal lobe epilepsy (TLE) was neurologist Norman Geschwind, who noted a set of religious behavioral traits associated with TLE seizures.[25] These include hypergraphia, hyperreligiosity, reduced sexual interest, fainting spells, and pedantism, often collectively ascribed to a condition known as Geschwind syndrome.

Vilayanur S. Ramachandran explored the neural basis of the hyperreligiosity seen in TLE using the galvanic skin response (GSR), which correlates with emotional arousal, to determine whether the hyperreligiosity seen in TLE was due to an overall heightened emotional state or was specific to religious stimuli. Ramachandran presented two subjects with neutral, sexually arousing and religious words while measuring GSR. Ramachandran was able to show that patients with TLE showed enhanced emotional responses to the religious words, diminished responses to the sexually charged words, and normal responses to the neutral words. This study was presented as an abstract at a neuroscience conference and referenced in Ramachandran's book, Phantoms in the Brain,[26] but it has never been published in the peer-reviewed scientific press.

Research by Mario Beauregard at the University of Montreal, using fMRI on Carmelite nuns, has purported to show that religious and spiritual experiences include several brain regions and not a single 'God spot'. As Beauregard has said, "There is no God spot in the brain. Spiritual experiences are complex, like intense experiences with other human beings."[27] The neuroimaging was conducted when the nuns were asked to recall past mystical states, not while actually undergoing them; "subjects were asked to remember and relive (eyes closed) the most intense mystical experience ever felt in their lives as a member of the Carmelite Order."[28] A 2011 study by researchers at the Duke University Medical Center found hippocampal atrophy is associated with older adults who report life-changing religious experiences, as well as those who are "born-again Protestants, Catholics, and those with no religious affiliation".[29]

A 2016 study using fMRI found "a recognizable feeling central to ... (Mormon)... devotional practice was reproducibly associated with activation in nucleus accumbens, ventromedial prefrontal cortex, and frontal attentional regions. Nucleus accumbens activation preceded peak spiritual feelings by 1–3 s and was replicated in four separate tasks. ... The association of abstract ideas and brain reward circuitry may interact with frontal attentional and emotive salience processing, suggesting a mechanism whereby doctrinal concepts may come to be intrinsically rewarding and motivate behavior in religious individuals."[30]

Psychopharmacology

Some scientists working in the field hypothesize that the basis of spiritual experience arises in neurological physiology. Speculative suggestions have been made that an increase of N,N-dimethyltryptamine levels in the pineal gland contribute to spiritual experiences.[31][32] Scientific studies confirming this have yet to be published. It has also been suggested that stimulation of the temporal lobe by psychoactive ingredients of 'Magic Mushrooms' mimics religious experiences.[33] This hypothesis has found laboratory validation with respect to psilocybin.

Evidence-based practice

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