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The Toyota Prius is the world's top selling hybrid electric vehicle, with global sales of almost 4 million units through January 2017.
 
A Brazilian filling station with four alternative fuels for sale: biodiesel (B3), gasohol (E25), neat ethanol ( E100), and compressed natural gas (CNG).
 
The Chevrolet Volt family was the world's top selling plug-in hybrid as of 2016, with global sales of about 134,500 units as of December 2016.

An alternative fuel vehicle is a motor vehicle that runs on alternative fuel, an energy other than traditional petroleum fuels (petrol or Diesel fuel); the term also refers to any technology of powering an engine that does not involve solely petroleum (e.g. electric car, hybrid electric vehicles, solar-powered vehicles). Because of a combination of factors, such as environmental concerns, high oil-prices and the potential for peak oil, development of cleaner alternative fuels and advanced power systems for vehicles has become a high priority for many governments and vehicle manufacturers around the world.

Vehicle engines powered by gasolene/petrol first emerged in the 1860s and 1870s; they took until the 1930s to completely dominate the original "alternative" engines driven by steam (18th century), by gases (early 19th century), or by electicity (c. 1830s).

Hybrid electric vehicles such as the Toyota Prius are not actually alternative fuel vehicles, but through advanced technologies in the electric battery and motor/generator, they make a more efficient use of petroleum fuel. Other research-and-development efforts in alternative forms of power focus on developing all-electric and fuel cell vehicles, and even on the stored energy of compressed air.

An environmental analysis of the impacts of various vehicle-fuels extends beyond just operating efficiency and emissions, especially if a technology comes into wide use. A life-cycle assessment of a vehicle involves production and post-use considerations. A cradle-to-cradle design is more important than a focus on a single factor such as the type of fuel.

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