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Friday, February 24, 2023

Social determinants of health

From Wikipedia, the free encyclopedia
 
Social Determinants of Health: Five Key Domains

The social determinants of health (SDOH) are the economic and social conditions that influence individual and group differences in health status. They are the health promoting factors found in one's living and working conditions (such as the distribution of income, wealth, influence, and power), rather than individual risk factors (such as behavioral risk factors or genetics) that influence the risk for a disease, or vulnerability to disease or injury. The distributions of social determinants are often shaped by public policies that reflect prevailing political ideologies of the area.

The World Health Organization says that "the social determinants can be more important than health care or lifestyle choices in influencing health." and "This unequal distribution of health-damaging experiences is not in any sense a 'natural' phenomenon but is the result of a toxic combination of poor social policies, unfair economic arrangements [where the already well-off and healthy become even richer and the poor who are already more likely to be ill become even poorer], and bad politics."

Issues of particular focus are social determinants of mental health, social determinants of health in poverty and social determinants of obesity.

Historical development

Social Determinants of Health visualization

Starting in the early 2000s, the World Health Organization facilitated the academic and political work on social determinants in a way that provided a deep understanding of health disparities in a global perspective.

In 2003, the World Health Organization (WHO) Europe suggested that the social determinants of health included: the social gradient, stress, early life, social exclusion, work, unemployment, social support, addiction, food, and transportation.

In 2008, the WHO Commission on Social Determinants of Health published a report entitled "Closing the Gap in a Generation", which aimed to understand, from a social justice perspective, how health inequity could be remedied, and what actions could combat factors that exacerbated injustices. The work of the commission was based on development goals, and thus, connected SDH (social determinants of health) discourse to economic growth and bridging gaps in the healthcare system. This report identified two broad areas of social determinants of health that needed to be addressed. The first area was daily living conditions, which included healthy physical environments, fair employment, and decent work, social protection across the lifespan, and access to health care. The second major area was distribution of power, money, and resources, including equity in health programs, public financing of action on the social determinants, economic inequalities, resource depletion, healthy working conditions, gender equity, political empowerment, and a balance of power and prosperity of nations.

The 2010 Affordable Care Act (ACA) established by the Obama administration in the United States, embodied the ideas put in place by the WHO by bridging the gap between community-based health and healthcare as a medical treatment, meaning that a larger consideration of social determinants of health was emerging in the policy. The ACA established community change through initiatives like providing Community Transformation Grants to community organizations, which opened up further debates and talks about increased integration of policies to create change on a larger scale.

The 2011 World Conference on Social Determinants of Health, in which 125 delegations participated, created the Rio Political Declaration on Social Determinants of Health. With a series of affirmations and announcements, the Declaration aimed to communicate that the social conditions in which an individual exists were key to understanding health disparities that individual may face, and it called for new policies across the world to fight health disparities, along with global collaborations.

Commonly accepted social determinants

The United States Centers for Disease Control and Prevention (CDC) defines social determinants of health as "life-enhancing resources, such as food supply, housing, economic and social relationships, transportation, education, and health care, whose distribution across populations effectively determines length and quality of life." These include access to care and resources such as food, insurance coverage, income, housing, and transportation.

According to a report by the Center for Migration Studies of New York, the different social determinants of health are strongly correlated. People living in an area with one identified determinant also tend to be affected by other determinants. Social determinants of health influence health-promoting behaviors, and health equity among the population is not possible without equitable distribution of social determinants among groups.

A commonly used model that illustrate the relationship between biological, individual, community, and societal determinants is Whitehead and Dahlgren's model originally presented in 1991 and has been adapted by the CDC. Additionally, within the United States, the Healthy People 2030 is an objective-driven framework which can guide public health practitioners and healthcare providers on how to address social determinants of health at the community level.

In Canada, these social determinants of health have gained wide usage: Income and income distribution; Education; Unemployment and job security; Employment and working conditions; Early childhood development; Food insecurity; Housing; Social exclusion/inclusion; Social safety network; Health services; Aboriginal status; Gender; Race; Disability.

The list of social determinants of health can be much longer. A recently published article identified several other social determinants. Unfortunately, there is no agreed taxonomy or criteria as to what should be considered a social determinant of health. In the literature, a subjective assessment—whether social factors impacting health are avoidable through structural changes in policy and practice—seems to be the dominant way of identifying a social determinant of health. The increase of artificial intelligence (AI) being used in clinical care raises numerous opportunities for addressing health equity issues, yet clear models and procedures for data characteristics and design have not been embraced consistently across health systems and providers.

Gender

The World Health Organization (WHO) has defined health as "a state of complete physical, mental, and social well-being and not merely the absence of disease or infirmity." Identified by the 2012 World Development Report as one of two key human capital endowments, health can influence an individual's ability to reach his or her full potential in society. Yet while gender equality has made the most progress in areas such as education and labor force participation, health inequality between men and women continues to harm many societies to this day.

While both males and females face health disparities, women have historically experienced a disproportionate amount of health inequity. This stems from the fact that many cultural ideologies and practices have created a structured patriarchal society where women are vulnerable to abuse and mistreatment. Additionally, women are typically restricted from receiving certain opportunities such as education and paid labor that can help improve their accessibility to better health care resources. Females are also frequently underrepresented or excluded from mixed-sex clinical trials and therefore subjected to physician bias in diagnosis and treatment.

Race

Race and health refers to how being identified with a specific race influences health. Race is a complex concept that has changed across chronological eras and depends on both self-identification and social recognition. In the study of race and health, scientists organize people in racial categories depending on different factors such as: phenotype, ancestry, social identity, genetic makeup and lived experience. "Race" and ethnicity often remain undifferentiated in health research.

Differences in health status, health outcomes, life expectancy, and many other indicators of health in different racial and ethnic groups are well documented. Epidemiological data indicate that racial groups are unequally affected by diseases, in terms or morbidity and mortality. Some individuals in certain racial groups receive less care, have less access to resources, and live shorter lives in general. Overall, racial health disparities appear to be rooted in social disadvantages associated with race such as implicit stereotyping and average differences in socioeconomic status.

Health disparities are defined as "preventable differences in the burden of disease, injury, violence, or opportunities to achieve optimal health that are experienced by socially disadvantaged populations". According to the U.S. Centers for Disease Control and Prevention, they are intrinsically related to the "historical and current unequal distribution of social, political, economic and environmental resources".

The relationship between race and health has been studied from multidisciplinary perspectives, with increasing focus on how racism influences health disparities, and how environmental and physiological factors respond to one another and to genetics.

Ongoing debates

Steven H. Woolf, MD of the Virginia Commonwealth University Center on Human Needs states, "The degree to which social conditions affect health is illustrated by the association between education and mortality rates." Reports in 2005 revealed the mortality rate was 206.3 per 100,000 for adults aged 25 to 64 years with little education beyond high school, but was twice as great (477.6 per 100,000) for those with only a high school education and three times as great (650.4 per 100,000) for those less educated. Based on the data collected, the social conditions such as education, income, and race were dependent on one another, but these social conditions also apply to independent health influences.

Marmot and Bell of the University College London found that in wealthy countries, income and mortality are correlated as a marker of relative position within society, and this relative position is related to social conditions that are important for health including good early childhood development, access to high quality education, rewarding work with some degree of autonomy, decent housing, and a clean and safe living environment. The social condition of autonomy, control, and empowerment turns are important influences on health and disease, and individuals who lack social participation and control over their lives are at a greater risk for heart disease and mental illness.

Early childhood development can be promoted or disrupted as a result of the social and environmental factors effecting the mother, while the child is still in the womb. Janet Currie's research finds that women in New York City receiving assistance from the Special Supplemental Nutrition Program for Women, Infants, and Children (WIC), in comparison to their previous or future childbirth, are 5.6% less likely to give birth to a child who is underweight, an indication that a child will have better short term, and long term physical, and cognitive development.

Several other social determinants are related to health outcomes and public policy, and are easily understood by the public to impact health. They tend to cluster together – for example, those living in poverty experience a number of negative health determinants.

International health inequalities

Health gap in England and Wales, 2011 Census

Even in the wealthiest countries, there are health inequalities between the rich and the poor. Researchers Labonte and Schrecker from the Department of Epidemiology and Community Medicine at the University of Ottawa emphasize that globalization is key to understanding the social determinants of health, and as Bushra (2011) posits, the impacts of globalization are unequal. Globalization has caused an uneven distribution of wealth and power both within and across national borders, and where and in what situation a person is born has an enormous impact on their health outcomes. The Organization for Economic Cooperation and Development found significant differences among developed nations in health status indicators such as life expectancy, infant mortality, incidence of disease, and death from injuries. Migrants and their family members also experience significant negatives health impacts.

These inequalities may exist in the context of the health care system, or in broader social approaches. According to the WHO's Commission on Social Determinants of Health, access to health care is essential for equitable health, and it argued that health care should be a common good rather than a market commodity. However, there is substantial variation in health care systems and coverage from country to country. The commission also calls for government action on such things as access to clean water and safe, equitable working conditions, and it notes that dangerous working conditions exist even in some wealthy countries. In the Rio Political Declaration on Social Determinants of Health, several key areas of action were identified to address inequalities, including promotion of participatory policy-making processes, strengthening global governance and collaboration, and encouraging developed countries to reach a target of 0.7% of gross national product (GNP) for official development assistance.

Theoretical approaches

The UK Black and The Health Divide reports considered two primary mechanisms for understanding how social determinants influence health: cultural/behavioral and materialist/structuralist The cultural/behavioral explanation is that individuals' behavioral choices (e.g., tobacco and alcohol use, diet, physical activity, etc.) were responsible for their development and deaths from a variety of diseases. However, both the Black and Health Divide reports found that behavioral choices are determined by one's material conditions of life, and these behavioral risk factors account for a relatively small proportion of variation in the incidence and death from various diseases.

The materialist/structuralist explanation emphasizes the people's material living conditions. These conditions include availability of resources to access the amenities of life, working conditions, and quality of available food and housing among others. Within this view, three frameworks have been developed to explain how social determinants influence health. These frameworks are: (a) materialist; (b) neo-materialist; and (c) psychosocial comparison. The materialist view explains how living conditions – and the social determinants of health that constitute these living conditions – shape health. The neo-materialist explanation extends the materialist analysis by asking how these living conditions occur. The psychosocial comparison explanation considers whether people compare themselves to others and how these comparisons affect health and wellbeing.

A nation's wealth is a strong indicator of the health of its population. Within nations, however, individual socio-economic position is a powerful predictor of health. Material conditions of life determine health by influencing the quality of individual development, family life and interaction, and community environments. Material conditions of life lead to differing likelihood of physical (infections, malnutrition, chronic disease, and injuries), developmental (delayed or impaired cognitive, personality, and social development), educational (learning disabilities, poor learning, early school leaving), and social (socialization, preparation for work, and family life) problems. Material conditions of life also lead to differences in psychosocial stress. When the fight-or-flight reaction is chronically elicited in response to constant threats to income, housing, and food availability, the immune system is weakened, insulin resistance is increased, and lipid and clotting disorders appear more frequently. The effects of chronic fight-or-flight is described in the allostatic load model.

The materialist approach offers insight into the sources of health inequalities among individuals and nations. Adoption of health-threatening behaviors is also influenced by material deprivation and stress. Environments influence whether individuals take up tobacco, use alcohol, consume poor diets, and have low levels of physical activity. Tobacco use, excessive alcohol consumption, and carbohydrate-dense diets are also used to cope with difficult circumstances. The materialist approach seeks to understand how these social determinants occur.

The neo-materialist approach is concerned with how nations, regions, and cities differ on how economic and other resources are distributed among the population. This distribution of resources can vary widely from country to country. The neo-materialist view focuses on both the social determinants of health and the societal factors that determine the distribution of these social determinants, and especially emphasizes how resources are distributed among members of a society.

The social comparison approach holds that the social determinants of health play their role through citizens' interpretations of their standings in the social hierarchy. There are two mechanisms by which this occurs. At the individual level, the perception and experience of one's status in unequal societies lead to stress and poor health. Feelings of shame, worthlessness, and envy can lead to harmful effects upon neuro-endocrine, autonomic and metabolic, and immune systems. Comparisons to those of a higher social class can also lead to attempts to alleviate such feelings by overspending, taking on additional employment that threaten health, and adopting health-threatening coping behaviors such as overeating and using alcohol and tobacco. At the communal level, widening and strengthening of hierarchy weakens social cohesion, which is a determinant of health. The social comparison approach directs attention to the psychosocial effects of public policies that weaken the social determinants of health. However, these effects may be secondary to how societies distribute material resources and provide security to its citizens, which are described in the materialist and neo-materialist approaches.

Life-course perspective

Life-course approaches emphasize the accumulated effects of experience across the life span in understanding the maintenance of health and the onset of disease. The economic and social conditions – the social determinants of health – under which individuals live their lives have a cumulative effect upon the probability of developing any number of diseases, including heart disease and stroke. Studies into the childhood and adulthood antecedents of adult-onset diabetes show that adverse economic and social conditions across the life span predispose individuals to this disorder.

Hertzman outlines three health effects that have relevance for a life-course perspective. Latent effects are biological or developmental early life experiences that influence health later in life. Low birth weight, for instance, is a reliable predictor of incidence of cardiovascular disease and adult-onset diabetes in later life. Nutritional deprivation during childhood has lasting health effects as well.

Pathway effects are experiences that set individuals onto trajectories that influence health, well-being, and competence over the life course. As one example, children who enter school with delayed vocabulary are set upon a path that leads to lower educational expectations, poor employment prospects, and greater likelihood of illness and disease across the lifespan. Deprivation associated with poor-quality neighborhoods, schools, and housing sets children off on paths that are not conducive to health and well-being.

Cumulative effects are the accumulation of advantage or disadvantage over time that manifests itself in poor health, in particular between women and men. These involve the combination of latent and pathways effects. Adopting a life-course perspective directs attention to how social determinants of health operate at every level of development – in utero, infancy, early childhood, childhood, adolescence, and adulthood – to both immediately influence health and influence it in the future.

Chronic stress and health

Stress is hypothesized to be a major influence in the social determinants of health. There is a relationship between experience of chronic stress and negative health outcomes. This relationship is explained through both direct and indirect effects of chronic stress on health outcomes.

The direct relationship between stress and health outcomes is the effect of stress on human physiology. The long term stress hormone, cortisol, is believed to be the key driver in this relationship. Chronic stress has been found to be significantly associated with chronic low-grade inflammation, slower wound healing, increased susceptibility to infections, and poorer responses to vaccines. Meta-analysis of healing studies has found that there is a robust relationship between elevated stress levels and slower healing for many different acute and chronic conditions However, it is also important to note that certain factors, such as coping styles and social support, can mitigate the relationship between chronic stress and health outcomes.

Stress can also be seen to have an indirect effect on health status. One way this happens is due to the strain on the psychological resources of the stressed individual. Chronic stress is common in those of a low socio-economic status, who are having to balance worries about financial security, how they will feed their families, housing status, and many other concerns. Therefore, individuals with these kinds of worries may lack the emotional resources to adopt positive health behaviors. Chronically stressed individuals may therefore be less likely to prioritize their health.

In addition to this, the way that an individual responds to stress can influence their health status. Often, individuals responding to chronic stress will develop potentially positive or negative coping behaviors. People who cope with stress through positive behaviors such as exercise or social connections may not be as affected by the relationship between stress and health, whereas those with a coping style more prone to over-consumption (i.e. emotional eating, drinking, smoking or drug use) are more likely to be see negative health effects of stress. Vape shops are also found more in low socioeconomic status areas. The owners target these areas in particular to gain profit. Since people with low-income status are not highly educated, they are more prone to make poor health behavior choices. Socioeconomic status also has a huge impact in lives of people of color. According to Kids Count Data Center, Children in Poverty 2014, in the United States 39% of African American children and adolescents, and 33% of Latino children and adolescents are living in poverty (Kids Count Data Center, Children in Poverty 2014). The stress these racial groups with low socioeconomic status face, is higher than the same race group from a high-income community. According to the research done on socioeconomic disparities in vape shop density and proximity to public schools, the researchers found that vape shops were located a lot more in the areas with schools where African-Americans/Latinos/Hispanic students were in higher population than the areas with schools where White population was more.

The detrimental effects of stress on health outcomes are hypothesized to partly explain why countries that have high levels of income inequality have poorer health outcomes compared to more equal countries. Wilkinson and Picket hypothesized in their book The Spirit Level that the stressors associated with low social status are amplified in societies where others are clearly far better off.

A landmark study conducted by the World Health Organization and the International Labour Organization found that exposure to long working hours, operating through psychosocial stress, is the occupational risk factor with the largest attributable burden of disease, i.e. an estimated 745,000 fatalities from ischemic heart disease and stroke events in 2016.

Improving health conditions worldwide

Reducing the health gap requires that governments build systems that allow a healthy standard of living for every resident.

Interventions

Three common interventions for improving social determinant outcomes as identified by the WHO are education, social security and urban development. However, evaluation of interventions has been difficult due to the nature of the interventions, their impact and the fact that the interventions strongly affect children's health outcomes.

  1. Education: Many scientific studies have been conducted and strongly suggests that increased quantity and quality of education leads to benefits to both the individual and society (e.g. improved labor productivity). Health and economic outcome improvements can be seen in health measures such as blood pressure, crime, and market participation trends. Examples of interventions include decreasing size of classes and providing additional resources to low-income school districts. However, there is currently insufficient evidence to support education as a social determinants intervention with a cost-benefit analysis.
  2. Social Protection: Interventions such as “health-related cash transfers”, maternal education, and nutrition-based social protections have been shown to have a positive impact on health outcomes. However, the full economic costs and impacts generated of social security interventions are difficult to evaluate, especially as many social protections primarily affect children of recipients. The landmark Cochrane Collaboration Review of the health impact of unconditional cash transfers in low- and middle-income countries found a large body of evidence that these cash transfers clinically meaningfully reduce in the likelihood of being sick (by an estimated 27%), may also improve food security and dietary diversity, and may also reduce extreme poverty and improve school attendance, as well as increase healthcare spending.
  3. Urban Development: Urban development interventions include a wide variety of potential targets such as housing, transportation, and infrastructure improvements. The health benefits are considerable (especially for children), because housing improvements such as smoke alarm installation, concrete flooring, removal of lead paint, etc. can have a direct impact on health. In addition, there is a fair amount of evidence to prove that external urban development interventions such as transportation improvements or improved walkability of neighborhoods (which is highly effective in developed countries) can have health benefits. Affordable housing options (including public housing) can make large contributions to both social determinants of health, as well as the local economy, and access to public natural areas -including green and blue spaces- is also associated with improved health benefits.

The Commission on Social Determinants of Health made recommendations in 2005 for action to promote health equity based on three principles: "improve the circumstances in which people are born, grow, live, work, and age; tackle the inequitable distribution of power, money, and resources, the structural drivers of conditions of daily life, globally, nationally, and locally; and measure the problem, evaluate action, and expand the knowledge base." These recommendations would involve providing resources such as quality education, decent housing, access to affordable health care, access to healthy food, and safe places to exercise for everyone despite gaps in affluence. Expansion of knowledge of the social determinants of health, including among healthcare workers, can improve the quality and standard of care for people who are marginalized, poor or living in developing nations by preventing early death and disability while working to improve quality of life.

Challenges of measuring value of interventions

Many economic studies have been conducted to measure the effectiveness and value of social determinant interventions but are unable to accurately reflect effects on public health due to the multi-faceted nature of the topic. While neither cost-effectiveness nor cost-utility analysis is able to be used on social determinant interventions, cost-benefit analysis is able to better capture the effects of an intervention on multiple sectors of the economy. For example, tobacco interventions have shown to decrease tobacco use, but also prolong lifespans, increasing lifetime healthcare costs and is therefore marked as a failed intervention by cost-effectiveness, but not cost-benefit. Another issue with research in this area is that most of the current scientific papers focus on rich, developed countries, and there is a lack of research in developing countries.

Policy changes that affect children also present the challenge that it takes a significant amount of time to gather this type of data. In addition, policies to reduce child poverty are particularly important, as elevated stress hormones in children interfere with the development of brain circuitry and connections, causing long term chemical damage. In most wealthy countries, the relative child poverty rate is 10 percent or less; in the United States, it is 21.9 percent. The lowest poverty rates are more common in smaller well-developed and high-spending welfare states like Sweden and Finland, with about 5 or 6 percent. Middle-level rates are found in major European countries where unemployment compensation is more generous and social policies provide more generous support to single mothers and working women (through paid family leave, for example), and where social assistance minimums are high. For instance, the Netherlands, Austria, Belgium and Germany have poverty rates that are in the 7 to 8 percent range.

Within clinical settings

Connecting patients with the necessary social services during their visits to hospitals or medical clinics is an important factor in preventing patients from experiencing decreased health outcomes as a result of social or environmental factors.

A clinical study done by researchers at the University of California San Francisco, indicated that connecting patients with the resources to utilize and contact social services during clinical visits, significantly decreased families social needs and significantly improved children's overall health.

In addition, within the clinical setting, it was noted that in order to better health outcomes for the patients in any clinical setting, a collection of SHD data should be documented. This helps maintain the connection between healthcare systems and organizations that address these needs that were documented.

Public policy

The Rio Political Declaration on Social Determinants of Health embraces a transparent, participatory model of policy development that, among other things, addresses the social determinants of health leading to persistent health inequalities for indigenous peoples. In 2017, citing the need for accountability for the pledges made by countries in the Rio Political Declaration on Social Determinants of Health, the World Health Organization and United Nations Children's Fund called for the monitoring of intersectoral interventions on the social determinants of health that improve health equity.

The United States Department of Health and Human Services includes social determinants in its model of population health, and one of its missions is to strengthen policies which are backed by the best available evidence and knowledge in the field.  Social determinants of health do not exist in a vacuum. Their quality and availability to the population are usually a result of public policy decisions made by governing authorities. For example, early life is shaped by availability of sufficient material resources that assure adequate educational opportunities, food, and housing among others. Much of this has to do with the employment security and the quality of working conditions and wages. The availability of quality, regulated childcare is an especially important policy option in support of early life. These are not issues that usually come under individual control but rather they are socially constructed conditions which require institutional responses. A policy-oriented approach places such findings within a broader policy context. In this context, Health in All Policies has seen as a response to incorporate health and health equity into all public policies as means to foster synergy between sectors and ultimately promote health.

Yet it is not uncommon to see governmental and other authorities individualize these issues. Governments may view early life as being primarily about parental behaviors towards their children. They then focus upon promoting better parenting, assist in having parents read to their children, or urge schools to foster exercise among children rather than raising the amount of financial or housing resources available to families. Indeed, for every social determinant of health, an individualized manifestation of each is available. There is little evidence to suggest the efficacy of such approaches in improving the health status of those most vulnerable to illness in the absence of efforts to modify their adverse living conditions.

A team of the Cochrane Collaboration conducted the first comprehensive systematic review of the health impact of unconditional cash transfers, as an increasingly common up-stream, structural social determinant of health. The review of 21 studies, including 16 randomized controlled trials, found that unconditional cash transfers may not improve health services use. However, they lead to a large, clinically meaningful reduction in the likelihood of being sick by an estimated 27%. Unconditional cash transfers may also improve food security and dietary diversity. Children in recipient families are more likely to attend school, and the cash transfers may increase money spent on health care.

One of the recommendations by the Commission on the Social Determinants of Health is expanding knowledge – particularly to health care workers.

Although not addressed by the WHO Commission on Social Determinants of Health, sexual orientation and gender identity are increasingly recognized as social determinants of health.

With all the different health inequities and differences in quality of care addressed in social determinants of health, the American Hospital Association created the Value Initiative project which helps make healthcare more affordable to people of all types. It does this four different ways:

  1. It frames issues regarding the healthcare system and its pricing and affordability.
  2. It provides knowledge, resources, and tools for hospitals to supply affordable healthcare and increase value.
  3. The initiative collects data of hospital experiences to develop new federal policy solutions.
  4. Builds a platform for the American Hospital Association to discuss with policymakers to find solutions to the lack of affordable care.

This initiative educates the public and makes sure there is transparency in pricing of hospital bills, making sure patients are not billed more than they should be. It also addresses the cost drivers in the healthcare system, and urges for legislators to take action to make healthcare affordable and to prioritize health over profit. This organization asks congress to control the rising costs of pharmaceuticals by encouraging competition between manufacturers, and improving transparency in drug pricing. In this value initiative, they have started the Affordability Advocacy Agenda (AAA) which improves the ongoing policy and advocacy activities. With the Covid-19 pandemic health care spending increased and there was a rise in hospitalizations and therefore a rise in demand for health care providers. The price for care has increased and there aren't enough workers to meet the demand for care. The AAA and congress are working together to provide relief from the pandemic in order to make healthcare more affordable to all.

As of January 1, 2022 there are regulations placed for healthcare providers about no surprise billing. This is the "No Surprises Act" of division BB of the Consolidated Appropriations Act, 2021 and this rule was made by the Biden-Harris administration. Patients should not be billed more than they expected to pay, it is often noticed with emergency services and this rule will stop patients from getting worried about any bills out of their budget, and they will be able to get the proper care they need for their health with peace of mind. The act was passed by congress at the end of 2020 and offers protection against insured Americans getting surprise bills from out-of-network providers. They struggled to find an amount that an insurer should pay to the out-of-network provider, but eventually found an amount and the law is now in effect as of January 2022. When it comes to out-of-network providers, patients often rely on these services in an emergency and then get stuck with the bill afterwards. Air Ambulance bills are a big problem for consumers, not just because they are out of network and cost a lot, but also for their lack of billing transparency. Since the Airline Deregulation Act, which allows air ambulance to make their own prices, federal solutions to this increasing cost of emergency care is needed. A possible solution is to allow air ambulance services to be administered and financed in a way that combines competitive bidding and public utility regulation.

Diseases of affluence

From Wikipedia, the free encyclopedia

Diseases of affluence, previously called diseases of rich people, is a term sometimes given to selected diseases and other health conditions which are commonly thought to be a result of increasing wealth in a society. Also referred to as the "Western disease" paradigm, these diseases are in contrast to so-called "diseases of poverty", which largely result from and contribute to human impoverishment. These diseases of affluence have vastly increased in prevalence since the end of World War II.

Examples of diseases of affluence include mostly chronic non-communicable diseases (NCDs) and other physical health conditions for which personal lifestyles and societal conditions associated with economic development are believed to be an important risk factor — such as type 2 diabetes, asthma, coronary heart disease, cerebrovascular disease, peripheral vascular disease, obesity, hypertension, cancer, alcoholism, gout, and some types of allergy. They may also be considered to include depression and other mental health conditions associated with increased social isolation and lower levels of psychological well-being observed in many developed countries. Many of these conditions are interrelated, for example obesity is thought to be a partial cause of many other illnesses.

In contrast, the diseases of poverty have tended to be largely infectious diseases, or the result of poor living conditions. These include tuberculosis, malaria, and intestinal diseases. Increasingly, research is finding that diseases thought to be diseases of affluence also appear in large part in the poor. These diseases include obesity and cardiovascular disease and, coupled with infectious diseases, these further increase global health inequalities.

Diseases of affluence started to become more prevalent in developing countries as diseases of poverty decline, longevity increases, and lifestyles change. In 2008, nearly 80% of deaths due to NCDs — including heart disease, strokes, chronic lung diseases, cancers and diabetes — occurred in low- and middle-income countries.

Main instances

According to the World Health Organization (WHO), the top 10 causes of deaths in high income/affluent countries in 2016 were from:

  1. Ischemic heart diseases
  2. Stroke
  3. Alzheimer disease and other dementia
  4. Trachea, bronchus and lung cancer
  5. Chronic obstructive pulmonary disease
  6. Lower respiratory infections
  7. Colon and rectum cancers
  8. Diabetes
  9. Kidney diseases
  10. Breast cancer

Except for the lower respiratory infections, all of them are non-communicable diseases. In 2016 WHO reported 56.9 million deaths worldwide, and more than half (54%), were due to the top causes of death previously mentioned.

Causes

Factors associated with the increase of these conditions and illnesses appear to be things that are a direct result of technological advances. They include:

  • Less strenuous physical exercise, often through increased use of motor vehicles
  • Irregular exercise as a result of office jobs involving no physical labor.
  • Easy accessibility in society to large amounts of low-cost food (relative to the much-lower caloric food availability in a subsistence economy)
    • More food generally, with much less physical exertion expended to obtain a moderate amount of food
    • Higher consumption of vegetable oils and high sugar-containing foods
    • Higher consumption of meat and dairy products
    • Higher consumption of refined flours and products made of such, like white bread or white noodles
    • More foods which are processed, cooked, and commercially provided (rather than seasonal, fresh foods prepared locally at the time of eating)
  • Prolonged periods of little activity
  • Greater use of alcohol and tobacco
  • Longer lifespans
    • Reduced exposure to infectious agents throughout life (this can result in a more idle and inexperienced immune system, as compared to an individual who experienced relatively frequent exposure to certain pathogens in their time of life)
  • Increased cleanliness. The hygiene hypothesis postulates that children of affluent families are now exposed to fewer antigens than has been normal in the past, giving rise to increased prevalence of allergy and autoimmune diseases.

Diabetes mellitus

Diabetes is a chronic metabolic disease characterized by increase blood glucose level. Type 2 diabetes is the most common form of diabetes. It is caused by resistance to insulin or the lack of production of insulin. It is seen most commonly in adults. Type 1 diabetes or juvenile diabetes affects mostly children. This condition is due to little or lack of insulin production from the pancreas.

According to WHO the prevalence of diabetes has quadrupled from 1980 to 422 million adults. The global prevalence of diabetes has increased from 4.7% in 1980 to 8.5% in 2014. Diabetes has been a major cause for blindness, kidney failure, heart attack, stroke and lower limb amputation.

Prevalence in countries of affluence

The Centers of Disease Control and Prevention (CDC) released a report in 2015 indicating that more than 100 million Americans have diabetes or pre-diabetes. Diabetes was the seventh leading cause of death in the United States in 2015. In developed countries like the United States, the risk for diabetes is seen in people with low socioeconomic status (SES). Socioeconomic status is defined by the education and the income level of a person. The prevalence of diabetes varies by education level. Of those diagnosed with diabetes:12.6% of adults had less than a high school education, 9.5% had a high school education and 7.2% had more than high school education.

Differences in diabetes prevalence are seen in the population and ethnic groups in USA. Diabetes is more common in non-Hispanic whites who are less educated and have a lower income. It is also more common in less educated Hispanics. The highest prevalence of diabetes is seen in the southeast, southern and Appalachian portion of the United States. In the United States the prevalence of diabetes is increasing in children and adolescents. In 2015, 25 million people were diagnosed with diabetes, of which 193,000 were children. The total direct and indirect cost of diagnosed diabetes in US in 2012 was $245 billion.

In 2009, the Canadian Diabetes Association (CDA) estimated that diagnosed diabetes will increase from 1.3 million in 2000 to 2.5 million in 2010 and 3.7 million in 2020. Diabetes was the 7th leading cause of death in Canada in 2015. Like United States, diabetes in more prevalent in the low socioeconomic group of people in Canada.

According to the International Diabetes Federation, more than 58 million people are diagnosed with diabetes in the European Union Region (EUR), and this will go up to 66.7 million by 2045. Similar to other affluent countries like America and Canada, diabetes is more prevalent in the poorer parts of Europe like Central and Eastern Europe.

In Australia according to self-reported data, 1 in 7 adults or approximately 1.2 million people had diabetes in 2014–2015. People who were living in remote or socioeconomically disadvantaged areas were 4 times more likely to develop type 2 diabetes as compared to non-indigenous Australians. Australia incurred $20.8 million in direct costs towards hospitalization, medication, and out-patient treatment towards diabetes. In 2015, $1.2 billion were lost in Australia's Gross Domestic Product (GDP) due to diabetes.

In these countries of affluence, diabetes is prevalent in low socioeconomic groups of people as there is abundance of unhealthy food choices, high energy rich food, and decreased physical activity. More affluent people are typically more educated and have tools to counter unhealthy foods, such as access to healthy food, physical trainers, and parks and fitness centers.

Risk factors

Obesity and being overweight is one of the main risk factors of type 2 diabetes. Other risk factors include lack of physical activity, genetic predisposition, being over 45 years old, tobacco use, high blood pressure and high cholesterol. In United States, the prevalence of obesity was 39.8% in adults and 18.5% in children and adolescents in 2015–2016. In Australia in 2014–2015, 2 out 3 adults or 63% were overweight or obese. Also, 2 out of 3 adults did little or no exercise. According to the World Health Organization, Europe had the 2nd highest proportion of overweight or obese people in 2014 behind the Americas.

In developing countries

According to WHO the prevalence of diabetes is rising more in the middle and low income countries. Over the next 25 years, the number of people with diabetes in developing countries will increase by over 150%. Diabetes is typically seen in people above the retirement age in developed countries, but in developing countries people in the age of 35-64 are mostly affected. Although, diabetes is considered a disease of affluence affecting the developed countries, there is more loss of life and premature death among people with diabetes in the developing countries. Asia accounts for 60% of the world's diabetic population. In 1980 less than 1% of Chinese adults were affected by diabetes, but by 2008 the prevalence was 10%. It is predicted that by 2030 diabetes may affect 79.4 million people in India, 42.3 million people in China and 30.3 million in United States.

These changes are the result of developing nations having rapid economic development. This rapid economic development has caused a change in the lifestyle and food habits leading to over-nutrition, increased intake of fast food causing increase in weight, and insulin resistance. Compared to the west, obesity in Asia is low. India has very low prevalence of obesity, but a very high prevalence of diabetes suggesting that diabetes may occur at a lower BMI in Indians as compared to the Europeans. Smoking increases the risk for diabetes by 45%. In developing countries around 50–60% adult males are regular smokers, increasing their risk for diabetes. In developing countries, diabetes is more commonly seen in the more urbanized areas. The prevalence of diabetes in rural population is 1/4th that of urban population for countries like India, Bangladesh, Nepal, Bhutan and Sri Lanka.

Cardiovascular disease

Cardiovascular disease refers to a disease of the heart and blood vessels. Conditions and diseases associated with heart disease include: stroke, coronary heart disease, congenital heart disease, heart failure, peripheral vascular disease, and cardiomyopathy. Cardiovascular disease is known as the world's biggest killer. 17.5 million people die from it each year, which equals 31% of all deaths. Heart disease and stroke cause 80% of these deaths.

Risk factors

High blood pressure is the leading risk factor for cardiovascular disease and has contributed to 12% of the cardiovascular related deaths worldwide. Other significant risk factors for heart disease include high cholesterol and smoking. 47% of all Americans have one of these three risk factors. Lifestyle choices, such as poor diet and physical inactivity, and excessive alcohol use can also contribute to cardiovascular disease. Medical conditions, like diabetes and obesity can also be risk factors.

Prevalence in countries of affluence

In the United States, 610,000 people die every year from heart disease which is equal to 1 in 4 deaths. The leading cause of death for both men and women in the United States is heart disease. In Canada, heart disease is the second leading cause of death. In 2014, it was the cause of death for 51,000 people. In Australia, heart disease is also the leading cause of death. 29% of deaths in 2015, had an underlying cause of heart disease. Heart disease causes one in four premature deaths in the United Kingdom and in 2015 heart disease caused 26% of all deaths in that country.

People of lower socio-economic status are more likely to have cardiovascular disease than those who have a higher socio-economic status. This inequality gap has occurred in developed countries because people who have a lower socio-economic status often face many of the risk factors of tobacco and alcohol use, obesity as well as having a sedentary lifestyle. Further social and environmental factors such as poverty, pollution, family history, housing and employment contribute to this inequality gap and to risk of having a health condition caused by cardiovascular disease. The increasing inequality gap between the higher and lower income populations continues in countries such as Canada, despite the availability of health care for everyone.

Alzheimer's disease and other dementias

Dementia is a chronic syndrome which is characterized by deterioration in the thought process beyond what is expected from normal aging. It affects the persons memory, thinking, orientation, comprehension, behavior and ability to perform everyday activity. There are many different forms of dementia . Alzheimer is the most common form which contributes to 60–70% of the dementia cases. Different forms of dementia can co-exist. Young onset dementia which occurs in individuals before the age of 65 contributes to 9% of the total cases. It is the major cause of disability and dependency among old people.

Worldwide, there are 50 million people with dementia and every year 10 million new cases are being reported. The total number of people with dementia is projected to reach 82 million by 2030 and 152 million in 2050 .

Prevalence in countries of affluence

According to CDC, Alzheimer is the 6th leading cause of death in U.S adults and 5th leading cause of death in adults over the age of 65. In 2014, 5 million Americans above the age of 65 were diagnosed with Alzheimer. This number is predicted to triple by the year 2060 and reach up to 14 million. Dementia and Alzheimer has been shown to go unreported on death certificates, leading to under representation of the actual mortality caused by these diseases. Between 2000 and 2015, mortality due to cardiovascular diseases has decreased by 11%, where as death from Alzheimer has increased by 123%. 1 in 3 people over the age of 65 die from Alzheimer or other forms of dementia. Furthermore, 200,000 individuals have been affected by young onset dementia. In United States, Alzheimer affects more women than men. It is twice more common in African-Americans and Hispanics than in whites. As the number of older Americans increases rapidly, the number of new cases of Alzheimer will rise too.

East Asia has the most people living with dementia (9.8 million) followed by Western Europe (7.5 million), South Asia (5.1 million) and North America (4.8 million). In 2016, the prevalence of Alzheimer was 5.05% in Europe. Like in United States, it is more prevalent in women than in men. In the European Union, Finland has the highest mortality among both men and women due to dementia. In Canada, over half a million people are living with dementia. It is projected that by 2031 the number will go up by 66% to 937,000. Every year 25,000 new cases of dementia are diagnosed .

Dementia is the second leading cause of death in Australia. In 2016, it was the leading cause of deaths in females. In Australia 436,366 people are living with dementia in 2018. 3 in 10 people over the age of 85 and 1 in 10 people over the age of 65 have dementia. It is the single greatest cause of disability in older Australians . Rates of dementia are higher for indigenous people. In people from the northern territory and western Australia the prevalence of dementia is 26 times higher in the 45–69 year old group and about 20 times greater in 60–69 year old group.

Risk factors in countries of affluence

The risk factors for developing dementia or Alzheimer's include age, family history, genetic factors, environmental factors, brain injury, viral infections, neurotoxic chemicals, and various immunological and hormonal disorders.

A new research study has found an association between the affluence of a country, hygiene conditions and the prevalence of Alzheimer in their population. According to the Hygiene Hypothesis, affluent countries with more urbanized and industrialized areas have better hygiene, better sanitation, clean water and improved access to antibiotics. This reduces the exposure to the friendly bacteria, virus and other microorganisms that help stimulate our immune system. Decreased microbial exposure leads to immune system that is poorly developed, which exposes the brain to inflammation as is seen in Alzheimer's disease.

Countries like the UK and France that have access to clean drinking water, improved sanitation facilities and have a high GDP show a 9% increase in Alzheimer's disease as opposed to countries like Kenya and Cambodia. Also countries like UK and Australia, where three quarters of their population lives in urban areas, have a 10% higher Alzheimer's rate than in countries like Bangladesh and Nepal where less than one tenth of their population live in urban areas.

Alzheimer's risk changes with the environment. Individuals from the same ethnic background living in an area of low sanitation will have a lower risk as compared to the same individuals living in an area of high sanitation who will be exposed to a higher risk of developing Alzheimer's. An African-American in U.S. has a higher risk of developing Alzheimer's as compared to one living in Nigeria. Immigrant populations exhibit Alzheimer disease rates intermediate between their home country and adopted country. Moving from a country of high sanitation to a country of low sanitation reduces the risk associated with the disease.

Mental illness

People who face poverty have more risks related to having a mental illness and also do not have as much access to treatment. The stressful events that they face, unsafe living condition and poor physical health lead to cycle of poverty and mental illness that is seen all over the world. According to the World Health Organization 76–85% of people living in lower and middle income countries are not treated for their mental illness. For those in higher-income counties, 35–50% of people with mental illness do not receive treatment. It is estimated that 90% of deaths by suicide are caused by substance use disorders and mental illness in higher income countries. In lower to middle income countries, this number is lower.

Prevalence of mental illness

One in four people have experienced mental illness at one time in their lives, and approximately 450 million people in the world currently have a mental illness. Those who are impoverished live in conditions associated with a higher risk for mental illness and, to compound the issue, do not have as much access to treatment. Stress, unsafe living conditions, and poor physical health associated with lack of sufficient income lead to a cycle of poverty and mental illness that is observed worldwide. Of all countries, India, China, and the United States have the highest levels of anxiety, depression and schizophrenia, according to the WHO. The proportion of people with depression is between 2% to 6%; Greenland, Australia, and the United States have the highest rates of this disorder. Of these three, the U.S. is reported to have the greatest rate of depression. In the U.S., approximately one in five adults has a mental illness, or 44.7 million people. In 2016, it was estimated that 268 million people in the world had depression.

Anxiety disorders, such as generalized anxiety, Obsessive Compulsive Disorder, and Post Traumatic Stress Disorder affected 275 million people worldwide in 2016. The global proportion of people affected by anxiety disorders is between 2.5 and 6.5%. Australia, Brazil, Argentina, Iran, the United States, and a number of countries in Western Europe appear to have a higher prevalence of anxiety disorders.

Cancer

Cancer is a generic term for a large group of disease which is characterized by rapid creation of abnormal cells that grow beyond their usual boundaries. These cells can invade adjoining parts of the body and spread to other organs causing metastases, which is a major cause of death. According to WHO, Cancer is the second leading cause of death globally. One in six deaths worldwide are caused due to cancer, accounting to a total of 9.6 million deaths in 2018. Tracheal, bronchus, and lung cancer is the leading form of cancer deaths across most high and middle-income countries.

Prevalence in countries of affluence

In United States, 1,735,350 new cases of cancer will be diagnosed in 2018. Most common forms of cancer are cancer of the breast, lung, bronchus, prostate, colorectal cancer, melanoma of skin, Non-Hodgkin's lymphoma, renal cancer, thyroid cancer and liver cancer. Cancer mortality is higher among men than in women. African-Americans have the highest risk of mortality due to cancer. Cancer is also the leading cause of death in Australia. The most common cancers in Australia are prostate, breast, colorectal, melanoma and lung cancer. These account for 60% of the cancer cases diagnosed in Australia.

Europe contains only 1/8 of the world population, but has around one quarter of the global cancer cases, with 3.7 million new cases each year. Lung, breast, stomach, liver, colon are the most common cancers in Europe. The overall incidences among different cancers vary across countries.

About one in two Canadians will develop cancer in their lifetime, and one in four will die of the disease. In 2017, 206,200 new cases of cancer were diagnosed. Lung, colorectal, breast, and prostate cancer accounted for about half of all cancer diagnoses and deaths.

Risk factors

High prevalence of cancer in high-income countries is attributed to lifestyle factors like obesity, smoking, physical inactivity, diet and alcohol intake. Around 40% of the cancers can be prevented by modifying these factors.

Allergies/autoimmune diseases

The rate of allergies around the world has risen in industrialized nations over the past 50 years. A number of public health measures, such as sterilized milk, use of antibiotics and improved food production have contributed to a decrease in infections in developed countries. There is a proposed causal relationship, known as the "hygiene hypothesis" that indicates that there are more autoimmune disorders and allergies in developed countries with fewer infections. In developing countries, it is assumed that the rates of allergies are lower than developed countries. That assumption may not be accurate due to limited data on prevalence. Research has found an increase in asthma by 10% in countries such as Peru, Costa Rica, and Brazil.

Causes of mental disorders

From Wikipedia, the free encyclopedia
 
Image 1: The prevalence of mental illness is higher in more unequal rich countries

A mental disorder is an impairment of the mind disrupting normal thinking, feeling, mood, behavior, or social interactions, and accompanied by significant distress or dysfunction. The causes of mental disorders are very complex and vary depending on the particular disorder and the individual. Although the causes of most mental disorders are not fully understood, researchers have identified a variety of biological, psychological, and environmental factors that can contribute to the development or progression of mental disorders. Most mental disorders result in a combination of several different factors rather than just a single factor.

Research results

Risk factors for mental illness include psychological trauma, adverse childhood experiences, genetic predisposition, and personality traits. Correlations of mental disorders with drug use include almost all psychoactive substances, e.g., cannabis, alcohol, and caffeine.

Mental illnesses have risk factors, for instance including unequal parental treatment, adverse life events and drug use in depression, migration and discrimination, childhood trauma, loss or separation in families, and cannabis use in schizophrenia and psychosis, and parenting factors, child abuse, family history (e.g. of anxiety), and temperament and attitudes (e.g. pessimism) in anxiety. Many psychiatric disorders include problems with impulse and other emotional control.

In February 2013, a study found genetic links between five major psychiatric disorders: autism, ADHD, bipolar disorder, major depressive disorder, and schizophrenia. Abnormal functioning of neurotransmitter systems is also responsible for some mental disorders, including serotonin, norepinephrine, dopamine, and glutamate system's abnormal functioning. Differences have also been found in the size or activity of specific brain regions in some cases. Psychological mechanisms have also been implicated, such as cognitive (e.g. reasoning) biases, emotional influences, personality dynamics, temperament, and coping style. Studies have indicated that variation in genes can play an important role in the evolution of mental disorders, although the reliable identification of connections between specific genes and specific disorders has proven more difficult. Environmental events surrounding pregnancy (such as maternal hypertension, preeclampsia, or infection) and birth have also been implicated. Traumatic brain injury may increase the risk of developing certain mental disorders. Throughout the years, there have been inconsistent links found to certain viral infections, substance misuse, and general physical health that have been false.

Adverse experiences affect a person's mental health, including abuse, neglect, bullying, social stress, traumatic events, and other overwhelming life experiences. The specific risks and pathways to particular disorders are less clear, however. Aspects of the wider community have also been implicated, including employment problems, socioeconomic inequality, lack of social cohesion, problems linked to migration, and features of particular societies and cultures. Mental stress is a common cause of mental illnesses, so finding a coping solution to cope with mental stress would be beneficial. Many solutions that have helped reduce stress are yoga, exercise, and some medications that may help.

Theories

General theories

Several theories or models seek to explain the causes (etiology) of mental disorders. These theories may differ in regards to how they explain the cause of the disorder, how to treat the disorder, and how they classify mental disorders. Theories also differ about the philosophy of mind they accept; that is, whether the mind and brain are identical or not.

During most of the 20th century, mental illness was ascribable to problematic relationships between children and their parents. This view was held well into the late 1990s, in which people still believed this child-parent relationship was a large determinant of severe mental illness, such as depression and schizophrenia. In the 21st century, additional factors have been identified such as genetic contributions, though experience also plays a role. So, the perceived causes of mental illness have changed over time and will most likely continue to alter while more research develops throughout the years.

Outside the West, community approaches remain a focus.

A practical mixture of models will explain particular issues and disorders, although there may be difficulty defining boundaries for indistinct psychiatric syndromes.

Medical or biomedical model

An overall distinction is also commonly made between a "medical model" (also known as a biomedical or disease model) and a "social model" (also known as an empowerment or recovery model) of mental disorder and disability, with the former focusing on hypothesized disease processes and symptoms, along with latter focusing on hypothesized social constructionism and social contexts.

Biological psychiatry has tended to follow a biomedical model focused on organic or "hardware" pathology of the brain, where many mental disorders are conceptualized as disorders of brain circuits shaped by a complex interplay of genetics and experience.

The social and medical models of mental disorders each work to identify and study distinct aspects, solutions, and potential therapies of disorders. The intersection and cross reference between the two models can further be used to develop more holistic models of mental disorders. Many criticisms historically of each model is the exclusivity of the other perspective. Therefore, intersectional research improved the impact and importance of future findings.

Biopsychosocial model

The primary model of contemporary mainstream Western psychiatry is the biopsychosocial model (BPS), which integrates biological, psychological, and social factors. The Biopsychosocial model was first conceptualised by George Engel in 1977, suggesting that to understand a person's medical condition it is not simply the biological factors to consider, but also the psychological and social factors . The biopsychosocial approach systematically considers biological, psychological, and social factors and their complex interactions in understanding health, illness, and health care delivery. Biological, psychological, and social factors exist along a continuum of natural systems. The factors within the model contain the following:

  • Biological (physiological pathology)
  • Psychological (thoughts emotions and behaviours such as psychological distress, fear/avoidance beliefs, current coping methods and attribution)
  • Social (socio-economical, socio-environmental, and cultural factors suchs as work issues, family circumstances and benefits/economics)

This model is commonly used for case conceptualization of psychological disorders as well as chronic pain, with the view that the pain is a psychophysiological behavior pattern that cannot be categorised into biological, psychological, or social factors alone.

A related view, the diathesis-stress model, posits that mental disorders result from genetic dispositions and environmental stressors, combining to cause patterns of distress or dysfunction. The model is one way to explain why some individuals are more vulnerable to mental disorders than others. Additionally, it explains why some people may develop a mental disorder after exposure to stressful life events while others do not.

Psychoanalytic theories

Psychoanalytic theories focus on unresolved internal and relational conflicts. These theories have been predicated as explanations of mental disorders. Many psychoanalytic groups are said to adhere to the biopsychosocial model and to accept an eclectic mix of subtypes of psychoanalysis. Sigmund Freud developed the psychoanalytic theory. This theory focuses on the impact of unconscious forces on human behavior. According to Freud, a personality has three parts: the id, ego, and superego. The id operates under the pleasure principle, the ego operates under the reality principle, and the superego is the "conscience" and incorporates what is and is not socially acceptable into a person's value system. According to the psychoanalytic theory, there are five stages of psychosexual development that everyone goes through the oral stage, anal stage, phallic stage, latency stage, and genital stage. Mental disorders can be caused by an individual receiving too little or too much gratification in one of the psychosexual developmental stages. When this happens, the individual is said to be in that developmental stage.

Attachment theory

Attachment theory is a kind of evolutionary-psychological approach sometimes applied in the context of mental disorders, which focuses on the role of early caregiver-child relationships, responses to danger, and the search for a satisfying reproductive relationship in adulthood. According to this theory, a child's attachment is to a nurturing adult, the more likely that child will maintain healthy relationships with others in their life. As found by the Strange Situation experiment run by Mary Ainsworth based on the formulations of John Bowlby, there are four patterns of attachment: secure attachment, avoidant attachment, disorganized attachment, and ambivalent attachment. Later research found the fourth pattern of attachment is known as disorganized disoriented attachment. Secure attachments reflect trust in the child-caretaker relationship while insecure attachment reflects mistrust. The security of attachment in a child affects the child's emotional, cognitive, and social competence later in life.

Evolutionary psychology

Evolutionary psychology and evolutionary psychiatry posit that mental disorders involve the dysfunctional operation of mental modules adapted to ancestral physical or social environments but not necessarily to modern ones. Behavioral abnormalities that resemble human mental illness have been found in related species (great apes).

Other theories suggest that mental illness could have evolutionary advantages for the species, including enhancing creativity and stress to enhance survival by activating the flight-or-fight response in anticipation of danger.

Schizophrenia could have been beneficial in prehistoric times by improving creativity during stressful times, or by helping to disseminate delusional tales that would have aided in-group cohesion and finding gullible mates. The paranoia associated with Schizophrenia could have prevented danger from other humans and other animals.

Mania and depression could have benefited from seasonal changes by helping to increase energy levels during times of plenty and rejuvenating energy during times of scarcity. In this way, mania was set in motion during the spring and summer to facilitate energy for hunting; depression worked best during the winter, similar to how bears hibernate to recover their energy levels. This may explain the connection between circadian genes and Bipolar Disorder and explain the relationship between light and seasonal affective disorder.

Biological factors

Biological factors consist of anything physical that can cause adverse effects on a person's mental health. Biological factors include genetics, prenatal damage, infections, exposure to toxins, brain defects or injuries, and substance abuse. Many professionals believe that the cause of mental disorders is the biology of the brain and the nervous system.

Mind mentions genetic factors, long-term physical health conditions, and head injuries or epilepsy (affecting behavior and mood) as factors that may trigger an episode of mental illness.

Genetics

Some rare mental disorders are caused only by genetics such as Huntington's disease.

Family linkage and some twin studies have indicated that genetic factors often play a role in the heritability of mental disorders. The reliable identification of specific genetic variation can cause indication of higher risk to particular disorders, through linkage, Genome Wide Association Scores or association studies, has proven difficult. This is due to the complexity of interactions between genes, environmental events, and early development or the need for new research strategies. No specific gene results in a complex trait disorder, but specific variations of alleles result in higher risk for a trait. The heritability of behavioral traits associated with a mental disorder may be in permissive than in restrictive environments, and susceptibility genes probably work through both "within-the-skin" (physiological) pathways and "outside-the-skin" (behavioral and social) pathways. Investigations increasingly focus on links between genes and endophenotypes because they are more specific traits. Some include neurophysiological, biochemical, endocrinological, neuroanatomical, cognitive, or neuropsychological, rather than disease categories. Concerning a well-known mental disorder, schizophrenia, it is said with certainty that alleles (forms of genes) were responsible for this disorder. Some research has indicated only multiple, rare mutations are thought to alter neurodevelopmental pathways that can ultimately contribute to schizophrenia; virtually every rare structural mutation was different in each individual.

Research has shown that many conditions are polygenic meaning there are multiple defective genes rather than only one that is responsible for a disorder, and these genes may also be pleiotropic meaning that they cause multiple disorders, not just one. Schizophrenia and Alzheimer's are both examples of hereditary mental disorders. When exonic genes encode for proteins, these proteins do not just affect one trait. The pathways that contribute to complex traits and phenotypes interact with multiple systems, even though proteins have specific functions. brain plasticity (neuroplasticity) raises questions of whether some brain differences may be caused by mental illnesses or by pre-existing and then causing them.

Prenatal damage

Any damage that occurs to a fetus while still in its mother's womb is considered prenatal damage. Mental disorders can develop if the pregnant mother uses drugs or alcohol or is exposed to illnesses or infections during pregnancy. Environmental events surrounding pregnancy and birth have increased the development of mental illness in the offspring. Some events may include maternal exposure to stress or trauma, conditions of famine, obstetric birth complications, infections, and gestational exposure to alcohol or cocaine. These factors have been hypothesized to affect areas of neurodevelopment, general development, and restrict neuroplasticity.

Infection, disease and toxins

There have been some findings of links between infection by the parasite Toxoplasma gondii and schizophrenia.

AIDS has been linked to some mental disorders. Research shows that infections and exposure to toxins such as HIV and streptococcus cause dementia. This HIV infection that makes its way to the brain is called encephalopathy which spreads itself through the brain leading to dementia. The infections or toxins that trigger a change in the brain chemistry can develop into a mental disorder.

Depression and emotional liability may be also be caused by babesiosis.

There is some evidence that there may be a relationship between BoDV-1 infection and psychiatric disease.

The research on Lyme disease caused by a deer tick and toxins is expanding the link between bacterial infections and mental illness.

Injury and brain defects

Any damage to the brain can cause a mental disorder. The brain is the control system for the nervous system and the rest of the body. Without it, the body cannot function properly.

Increased mood swings, insane behavior, and substance abuse disorders are traumatic brain injury (TBI) examples. Findings on the relationship between TBI severity and prevalence of subsequent psychiatric disorders have been inconsistent, and occurrence relates to prior mental health problems. Direct neurophysiological effects in a complex interaction with personality, attitude, and social influences.

Head trauma classifies as either open or closed head injury. In open head injury, the skull is punctured and the brain tissue is demolished. Closed head injury is more common, the skull is not punctured because there is an impact of the brain against the skull that creates permanent structural damage (subdural hematoma). With both types, symptoms may disappear or persist over time. Typically the longer the length of time spent unconscious and the length of post-traumatic amnesia the worse the prognosis for the individual. The cognitive residual symptoms of head trauma are associated with the type of injury (either an open head injury or closed head injury) and the amount of tissue destroyed. Closed injury head trauma symptoms include; Deficits in abstract reasoning ability, judgment, memory, and marked personality changes. Open injury head trauma symptoms tend to be the experience of classic neuropsychological syndromes like aphasia, visual-spatial disorders, and types of memory or perceptual disorders.

Brain tumors are classified as either malignant and benign, and as intrinsic (directly infiltrate the parenchyma of the brain) or extrinsic (grows on the external surface of the brain and produces symptoms as a result of pressure on the brain tissue). Progressive cognitive changes associated with brain tumors may include confusion, poor comprehension, and even dementia. Symptoms tend to depend on the location of the tumor in the brain. For example, tumors on the frontal lobe tend to be associated with the sign of impairment of judgment, apathy, and loss of the ability to regulate/modulate behavior.

Findings have indicated abnormal functioning of brainstem structures in individuals with mental disorders such as schizophrenia, and other disorders that have to do with impairments in maintaining sustained attention. Some abnormalities in the average size or shape of some regions of the brain have been found in some disorders, reflecting genes and experiences. Studies of schizophrenia have tended to find enlarged ventricles and sometimes reduced volume of the cerebrum and hippocampus, while studies of (psychotic) bipolar disorder have sometimes found increased amygdala volume. Findings differ over whether volumetric abnormalities are risk factors or are only found alongside the course of mental health problems, possibly reflecting neurocognitive or emotional stress processes and medication use or substance use. Some studies have also found reduced hippocampal volumes in major depression, possibly worsening with time depression.

Generic Neurotransmitter System

Neurotransmitter systems

Abnormal levels of dopamine activity correspond with several disorders (reduced in ADHD and OCD, and increased in schizophrenia). The dysfunction in serotonin and other monoamine neurotransmitters (norepinephrine and dopamine) correspond with certain mental disorders and their associated neural networks. Some include major depression, obsessive-compulsive disorder, phobias, post-traumatic stress disorder, and generalized anxiety disorder. Studies of depleted levels of monoamine neurotransmitters show an association with depression and other psychiatric disorders, but "... it should be questioned whether 5-HT [serotonin] represents just one of the final and not the main, factors in the neurological chain of events underlying psychopathological symptoms...."

Simplistic "chemical imbalance" explanations for mental disorders have never received empirical support; and most prominent psychiatrists, neuroscientists, and psychologists have not espoused such ill-defined, facile etiological theories. Instead, neurotransmitter systems have been understood in the context of the diathesis-stress or biopsychosocial models. The following 1967 quote from renowned psychiatric and neuroscience researchers exemplifies this more sophisticated understanding (in contrast to the woolly "chemical imbalance" notion).

Whereas specific genetic factors may be of importance in the etiology of some, and possibly all, depressions, it is equally conceivable that early experiences of the infant or child may cause enduring biochemical changes, that may predispose some individuals to depressions in adulthood. It is not likely that changes in the metabolism of the biogenic amines alone will account for the complex phenomena of normal or pathological affect.

Substance abuse

Substance abuse, especially long-term abuse, can cause or exacerbate many mental disorders. Alcoholism is linked to depression while abuse of amphetamines and LSD can leave a person feeling paranoid and anxious.

Correlations of mental disorders with drug use include cannabis, alcohol, and caffeine. At more than 300 mg, caffeine may cause anxiety or worsen anxiety disorders. Illicit drugs can stimulate particular parts of the brain that can affect development in adolescence. Cannabis has also been found to worsen depression and lessen an individual's motivation. Alcohol has the potential to damage "white matter" in the brain that affects thinking and memory. Alcohol is a problem in many countries due to many people participating in excessive drinking or binge drinking.

Life experience and environmental factors

The term "environment" is very loosely defined when it comes to mental illness. Unlike biological and psychological causes, environmental causes are stressors that individuals deal with in everyday life. These stressors range from financial issues to having low self-esteem. Environmental causes are more psychologically based, making them more closely related. Events that evoke feelings of loss or damage are most likely to cause a mental disorder to develop in an individual. Environmental factors include but are not limited to dysfunctional home life, poor relationships with others, substance abuse, not meeting social expectations, low self-esteem, and poverty.

Mind mentions childhood abuse, trauma, violence or neglect, social isolation, loneliness or discrimination, the death of someone close, stress, homelessness or housing, social disadvantage, poverty or debt, unemployment, caring for a family member or friend, significant trauma as an adult, such as military combat, and being involved in an accident or being the victim of a violent crime as possibly triggering an episode of mental illness.

Repeating generational patterns are a risk factor for mental illness.

Life events and emotional stress

Treatment in childhood and adulthood, including sexual abuse, physical abuse, emotional abuse, domestic violence, and bullying, has been linked to the development of mental disorders, through a complex interaction of societal, family, psychological and biological factors. Negative or stressful life events more generally have been implicated in the development of a range of disorders, including mood and anxiety disorders. The main risks appear to be from a cumulative combination of such experiences over time, although exposure to a single major trauma can sometimes lead to psychopathology, including PTSD. Resilience to such experiences varies, and a person may be resistant to some forms of experience but susceptible to others. Features associated with variations in resilience include genetic vulnerability, temperamental characteristics, cognitive set, coping patterns, and other experiences.

For bipolar disorder, stress (such as childhood adversity) is not a specific cause but does place genetically and biologically vulnerable individuals at risk for a more severe course of illness.

Poor parenting, abuse and neglect

Poor parenting is a risk factor for depression and anxiety. Separation or bereavement in families, and childhood trauma, be risk factors for psychosis and schizophrenia.

Severe psychological trauma, such as abuse, can wreak havoc on a person's life. Children are much more susceptible to psychological harm from traumatic events than adults. Once again, the reaction to the trauma will vary based on the person and the individual's age. Many factors impact these children. Many factors include the type of event, the length of exposure, and how the individual was affected. Study shows that human-induced trauma, such as a tumultuous childhood, affects children even more than natural disasters.

Neglect is a type of maltreatment related to the failure to provide needed, age-appropriate care, supervision, and protection. It is not to be confused with abuse, which, in this context, is defined as any action that intentionally harms or injures another person. Neglect most often happens during childhood by the parents or caretakers. Parents who are guilty of neglect were also neglected as children. The long-term effects of neglect are reduced physical, emotional, and mental health in a child and throughout adulthood.

Adverse childhood experiences

Adverse childhood experiences (ACEs) such as physical or emotional neglect or both, abuse, poverty, malnutrition, and traumatic experiences can have long-lasting negative consequences. Adverse experiences in childhood can affect the structural and functional development of the brain, giving structural and functional abnormalities in the future, and adulthood. ACEs and chronic trauma can disrupt the control of immune responses and promote chronic immune system activation giving rise to lasting inflammatory dysregulation. The Adverse Childhood Experiences Study has shown a strong dose–response relationship between ACEs and numerous health, social, and behavioral problems throughout a person's lifespan, including suicide attempts and frequency of depressive episodes. Several adverse childhood experiences can give a level of stress known as toxic stress. A child's neurological development can be disrupted when chronically exposed to stressful events such as physical, emotional, or sexual abuse, physical or emotional neglect, witnessing violence in the household, or a parent being incarcerated or having a mental illness. As a result, the child's cognitive functioning or ability to cope with negative or disruptive emotions can diminish. Over time, the child may adopt various harmful coping strategies that contribute to later disease and disability. Childhood adversity is associated with an increased risk of developing severe mental illnesses, including schizophrenia. Studies show that it could contribute to some features of the illness, including cognitive impairment. Findings from several studies have been mixed but some suggest that cognitive impairment is more related to forms of neglect than any other form of adversity. Underlying mechanisms remain unknown.

Familial and close relationships

Relationships and community have been extensively associated with mental health, success, and mental disorders. Home life and parental support impact social and mental development and health of individuals. Parental divorce, death, absence, or lack of continuity appears to increase risk, perhaps only if there is family discord or disorganization. Early social privation, or lack of ongoing, harmonious, secure, committed relationships, has been implicated in the development of mental disorders.

How an individual interacts with others as well as the quality of relationships can greatly increase or decrease a person's quality of living. Continuous conflict with friends, support system, and family can all lead to an increased risk of developing or worsening a mental illness or mental health state. A dysfunctional family may include disobedience, child neglect, and/or one with mental and/or abuse which occurs.

Divorce is also another factor that can take a toll on both children and adults alike. Divorcees may have emotional adjustment problems due to a loss of intimacy and social connections. Newer statistics show that the negative effects of divorce have been overstated. The effects of divorce on children can be impactful on the child's mental health and development.

Social expectations and esteem

How individuals view themselves ultimately determines who they are, their abilities, and what they can be. Having both too low of self-esteem or too high can be detrimental to an individual's mental health. A person's self-esteem plays a role in their overall happiness and quality of life. Poor self-esteem can result in aggression, violence, self-deprecating behavior, anxiety, and other mental disorders.

Not fitting in with the masses can result in bullying and other types of emotional abuse. Bullying can result in depression, feelings of anger, loneliness.

Poverty

National Geographic, 1917, Czech poor peasant children

Studies show that there is a direct correlation between poverty and mental illness. The lower the socioeconomic status of an individual the higher the risk of mental illness. Impoverished people are two to three times more likely to develop mental illness than those of a higher economic class.

Low levels of self-efficiency and self-worth are experienced by children of disadvantaged families or those from the economic underclass. Theorists of child development have argued that persistent poverty leads to high levels of psychopathology and poor self-concepts.

This increased risk for psychiatric complications remains consistent for all individuals among the impoverished population, regardless of any in-group demographic differences that they may possess. These families must deal with economic stressors like unemployment and lack of affordable housing, which leads to mental health disorders. A person's socioeconomic class outlines the psychosocial, environmental, behavioral, and biomedical risk factors that are associated with mental health.

According to findings, there is a strong association between poverty and substance abuse. Substance abuse only perpetuates a continuous cycle. It can make it extremely difficult for individuals to find and keep jobs. As stated earlier, both financial problems and substance abuse can cause mental illnesses to develop.

Communities and cultures

Problems in communities or cultures, including poverty, unemployment or underemployment, lack of social cohesion, and migration, have been associated with the development of mental disorders. Stresses and strains related to socioeconomic position (socioeconomic status (SES) or social class) have been linked to the occurrence of major mental disorders, with a lower or more insecure educational, occupational, economic, or social position generally linked to more mental disorders. There have been mixed findings on the nature of the links and on the extent to which pre-existing personal characteristics influence the links. Both personal resources and community factors have been implicated, as well as interactions between individual-level and regional-level income levels. The causal role of different socioeconomic factors may vary by country. Socioeconomic deprivation in neighborhoods can cause worse mental health, even after accounting for genetic factors. Minority ethnic groups, including first or second-generation immigrants, are at greater risk for developing mental disorders, which has been attributed to various kinds of life insecurities and disadvantages, including racism. The direction of causality is sometimes unclear, and alternative hypotheses such as the drift hypothesis sometimes need to be discounted.

Psychological and individual factors, including resilience

Some clinicians believe that psychological characteristics alone determine mental disorders. Others speculate that abnormal behavior can be explained by a mix of social and psychological factors. In many examples, environmental and psychological triggers complement one another resulting in emotional stress, which in turn activates a mental illness. Each person is unique in how they will react to psychological stressors. What may break one person may have little to no effect on another. Psychological stressors, which can trigger mental illness, are as follows: emotional, physical, or sexual abuse, loss of a significant loved one, neglect, and being unable to relate to others.

The inability to relate to others is also known as emotional detachment. Emotional detachment makes it difficult for an individual to empathize with others or to share their feelings.These individuals tend to stress the importance of their independence and tend to struggle relating to others.An emotionally detached person may try to rationalize or apply logic to a situation to which there is no logical explanation. Often, the inability to relate to others stems from a traumatic event.

Mental characteristics of individuals, as assessed by both neurological and psychological studies, have been linked to the development and maintenance of mental disorders. This includes cognitive or neurocognitive factors, such as the way a person perceives, thinks, or feels about certain things; or an individual's overall personality, temperament, or coping style or the extent of protective factors or "positive illusions" such as optimism, personal control and a sense of meaning.

Classical radicalism

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