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γ-Hydroxybutyric acid
4-Hydroxybutansäure - 4-Hydroxybutanoic acid.svg
GHB-3D-balls.png
Clinical data
Synonymsγ-Hydroxybutyric acid
γ-Hydroxybutyrate
GHB
Pregnancy
category
  • US: C (Risk not ruled out)
Routes of
administration
Usually by mouth; intravenous
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability25% (oral)
Metabolism95%, mainly liver, also in blood and tissues
Onset of actionWithin 5–15 min[1]
Elimination half-life30–60 minutes
Excretion5%, kidney
Identifiers
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
Chemical and physical data
FormulaC4H8O3
Molar mass104.10 g/mol (GHB)
126.09 g/mol (sodium salt)
142.19 g/mol (potassium salt)
3D model (JSmol)

γ-Hydroxybutyric acid (GHB), also known as 4-hydroxybutanoic acid, is a naturally occurring neurotransmitter and a psychoactive drug. It is a precursor to GABA, glutamate, and glycine in certain brain areas, and it acts on the GHB receptor and it is a weak agonist at the GABAB receptor.

GHB has been used in a medical setting as a general anesthetic and as a treatment for cataplexy, narcolepsy, and alcoholism. It is also used illegally as an intoxicant, to try to increase athletic performance, and as a date rape drug and as a recreational drug. It is commonly used in the form of a salt, such as sodium γ-hydroxybutyrate (Na.GHB, sodium oxybate, or Xyrem) or potassium γ-hydroxybutyrate (K.GHB, potassium oxybate).

GHB is also produced as a result of fermentation, and is found in small quantities in some beers and wines, beef and small citrus fruits.[5]

Succinic semialdehyde dehydrogenase deficiency is a disease that causes GHB to accumulate in the blood.