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Sunday, December 12, 2021

Pharmacy

From Wikipedia, the free encyclopedia
 
PharmacistsMortar.svg
Occupation
NamesPharmacist, Chemist, Doctor of Pharmacy, Druggist, Apothecary or simply Doctor
Occupation type
Professional
Activity sectors
Health care, health sciences, chemical sciences
Description
Education required
Doctor of Pharmacy, Master of Pharmacy, Bachelor of Pharmacy, Diploma in Pharmacy
Related jobs
Physician, pharmacy technician, toxicologist, chemist, pharmacy assistant, other medical specialists
The Green Pharmacy Cross (sometimes overlaid with Bowl of Hygieia), is widely used in Europe and India on pharmacy signs.
 
A medication is a drug used to diagnose, cure, treat, or prevent disease.
 
The Apothecary or The Chemist by Gabriël Metsu (c. 1651–67)

Pharmacy is the clinical health science that links medical science with chemistry and it is charged with the discovery, production, disposal, safe and effective use, and control of medications and drugs. The practice of pharmacy requires excellent knowledge of drugs, their mechanism of action, side effects, interactions, mobility and toxicity. At the same time, it requires knowledge of treatment and understanding of the pathological process. Some specialties of pharmacists, such as that of clinical pharmacists, require other skills, e.g. knowledge about the acquisition and evaluation of physical and laboratory data.

The scope of pharmacy practice includes more traditional roles such as compounding and dispensing of medications, and it also includes more modern services related to health care, including clinical services, reviewing medications for safety and efficacy, and providing drug information. Pharmacists, therefore, are the experts on drug therapy and are the primary health professionals who optimize the use of medication for the benefit of the patients.

An establishment in which pharmacy (in the first sense) is practiced is called a pharmacy (this term is more common in the United States) or a chemist's (which is more common in Great Britain, though pharmacy is also used). In the United States and Canada, drugstores commonly sell medicines, as well as miscellaneous items such as confectionery, cosmetics, office supplies, toys, hair care products and magazines, and occasionally refreshments and groceries.

In its investigation of herbal and chemical ingredients, the work of the apothecary may be regarded as a precursor of the modern sciences of chemistry and pharmacology, prior to the formulation of the scientific method.

Disciplines

Pharmacy, Tacuinum sanitatis casanatensis (14th century)

The field of pharmacy can generally be divided into three primary disciplines:

The boundaries between these disciplines and with other sciences, such as biochemistry, are not always clear-cut. Often, collaborative teams from various disciplines (pharmacists and other scientists) work together toward the introduction of new therapeutics and methods for patient care. However, pharmacy is not a basic or biomedical science in its typical form. Medicinal chemistry is also a distinct branch of synthetic chemistry combining pharmacology, organic chemistry, and chemical biology.

Pharmacology is sometimes considered as the fourth discipline of pharmacy. Although pharmacology is essential to the study of pharmacy, it is not specific to pharmacy. Both disciplines are distinct. Those who wish to practice both pharmacy (patient-oriented) and pharmacology (a biomedical science requiring the scientific method) receive separate training and degrees unique to either discipline.

Pharmacoinformatics is considered another new discipline, for systematic drug discovery and development with efficiency and safety.

Pharmacogenomics is the study of genetic-linked variants that effect patient clinical responses, allergies, and metabolism of drugs.

Professionals

The World Health Organization estimates that there are at least 2.6 million pharmacists and other pharmaceutical personnel worldwide.

Pharmacists

Pharmacists are healthcare professionals with specialized education and training who perform various roles to ensure optimal health outcomes for their patients through the quality use of medicines. Pharmacists may also be small business proprietors, owning the pharmacy in which they practice. Since pharmacists know about the mode of action of a particular drug, and its metabolism and physiological effects on the human body in great detail, they play an important role in optimization of drug treatment for an individual.

Pharmacists are represented internationally by the International Pharmaceutical Federation (FIP). They are represented at the national level by professional organisations such as the Royal Pharmaceutical Society in the UK, Pharmaceutical Society of Australia (PSA), Canadian Pharmacists Association (CPhA), Indian Pharmacist Association (IPA), Pakistan Pharmacists Association (PPA), American Pharmacists Association (APhA), and the Malaysian Pharmaceutical Society (MPS).

In some cases, the representative body is also the registering body, which is responsible for the regulation and ethics of the profession.

In the United States, specializations in pharmacy practice recognized by the Board of Pharmacy Specialties include: cardiovascular, infectious disease, oncology, pharmacotherapy, nuclear, nutrition, and psychiatry. The Commission for Certification in Geriatric Pharmacy certifies pharmacists in geriatric pharmacy practice. The American Board of Applied Toxicology certifies pharmacists and other medical professionals in applied toxicology.

Pharmacy support staff

Pharmacy technicians

Pharmacy technicians support the work of pharmacists and other health professionals by performing a variety of pharmacy-related functions, including dispensing prescription drugs and other medical devices to patients and instructing on their use. They may also perform administrative duties in pharmaceutical practice, such as reviewing prescription requests with medic's offices and insurance companies to ensure correct medications are provided and payment is received.

Legislation requires the supervision of certain pharmacy technician's activities by a pharmacist. The majority of pharmacy technicians work in community pharmacies. In hospital pharmacies, pharmacy technicians may be managed by other senior pharmacy technicians. In the UK the role of a PhT in hospital pharmacy has grown and responsibility has been passed on to them to manage the pharmacy department and specialized areas in pharmacy practice allowing pharmacists the time to specialize in their expert field as medication consultants spending more time working with patients and in research. Pharmacy technicians are registered with the General Pharmaceutical Council (GPhC). The GPhC is the regulator of pharmacists, pharmacy technicians, and pharmacy premises.

In the US, pharmacy technicians perform their duties under the supervision of pharmacists. Although they may perform, under supervision, most dispensing, compounding and other tasks, they are not generally allowed to perform the role of counseling patients on the proper use of their medications. Some states have a legally mandated pharmacist-to-pharmacy technician ratio.

Dispensing assistants

Dispensing assistants are commonly referred to as "dispensers" and in community pharmacies perform largely the same tasks as a pharmacy technician. They work under the supervision of pharmacists and are involved in preparing (dispensing and labelling) medicines for provision to patients.

Healthcare assistants/medicines counter assistants

In the UK, this group of staff can sell certain medicines (including pharmacy only and general sales list medicines) over the counter. They cannot prepare prescription-only medicines for supply to patients.

Education requirements

There are different requirements of schooling according to the national jurisdiction where the student intends to practise.

United States

In the United States, general pharmacist will attain a Doctor of Pharmacy Degree (Pharm.D.). The Pharm.D. can be completed in a minimum of six years, which includes two years of pre-pharmacy classes, and four years of professional studies. After graduating pharmacy school, it is highly suggested that the student go on to complete a one or two-year residency, which provides valuable experience for the student before going out independently to be a generalized or specialized pharmacist.

The curriculum specified for a Pharm.D. consists of at least 208-credit hours. Of the 208 credit hours, 68 are transferred-credit hours, and the remaining 140 credit hours are completed in the professional school. There are a series of required standardized tests that students have to pass throughout the process of pharmacy school. The standardized test to get into pharmacy school in the United States is called the Pharmacy College Admission Test (PCAT). In a student's third professional year in pharmacy school, it is required to pass the Pharmacy Curriculum Outcomes Assessment (PCOA). Once the Pharm.D. is attained after the fourth year of professional school, the student is then eligible to take the North American Pharmacist Licensure Exam (NAPLEX) and the Multistate Pharmacy Jurisprudence Exam (MPJE) to work as a professional pharmacist.

History

Physician and Pharmacist, illustration from Medicinarius (1505) by Hieronymus Brunschwig

The earliest known compilation of medicinal substances was the Sushruta Samhita, an Indian Ayurvedic treatise attributed to Sushruta in the 6th century BC. However, the earliest text as preserved dates to the 3rd or 4th century AD.

Many Sumerian (4th millennium BC – early 2nd millennium BC) cuneiform clay tablets record prescriptions for medicine.

Ancient Egyptian pharmacological knowledge was recorded in various papyri such as the Ebers Papyrus of 1550 BC, and the Edwin Smith Papyrus of the 16th century BC.

Dioscorides, De Materia Medica, Byzantium, 15th century

In Ancient Greece, Diocles of Carystus (4th century BC) was one of several men studying the medicinal properties of plants. He wrote several treatises on the topic. The Greek physician Pedanius Dioscorides is famous for writing a five-volume book in his native Greek Περί ύλης ιατρικής in the 1st century AD. The Latin translation De Materia Medica (Concerning medical substances) was used as a basis for many medieval texts and was built upon by many middle eastern scientists during the Islamic Golden Age, themselves deriving their knowledge from earlier Greek Byzantine medicine Byzantine Medicine.

Pharmacy in China dates at least to the earliest known Chinese manual, the Shennong Bencao Jing (The Divine Farmer's Herb-Root Classic), dating back to the 1st century AD. It was compiled during the Han dynasty and was attributed to the mythical Shennong. Earlier literature included lists of prescriptions for specific ailments, exemplified by a manuscript "Recipes for 52 Ailments", found in the Mawangdui, sealed in 168 BC.

In Japan, at the end of the Asuka period (538–710) and the early Nara period (710–794), the men who fulfilled roles similar to those of modern pharmacists were highly respected. The place of pharmacists in society was expressly defined in the Taihō Code (701) and re-stated in the Yōrō Code (718). Ranked positions in the pre-Heian Imperial court were established; and this organizational structure remained largely intact until the Meiji Restoration (1868). In this highly stable hierarchy, the pharmacists—and even pharmacist assistants—were assigned status superior to all others in health-related fields such as physicians and acupuncturists. In the Imperial household, the pharmacist was even ranked above the two personal physicians of the Emperor.

There is a stone sign for a pharmacy shop with a tripod, a mortar, and a pestle opposite one for a doctor in the Arcadian Way in Ephesus near Kusadasi in Turkey. The current Ephesus dates back to 400 BC and was the site of the Temple of Artemis, one of the seven wonders of the world.

In Baghdad the first pharmacies, or drug stores, were established in 754, under the Abbasid Caliphate during the Islamic Golden Age. By the 9th century, these pharmacies were state-regulated.

The advances made in the Middle East in botany and chemistry led medicine in medieval Islam substantially to develop pharmacology. Muhammad ibn Zakarīya Rāzi (Rhazes) (865–915), for instance, acted to promote the medical uses of chemical compounds. Abu al-Qasim al-Zahrawi (Abulcasis) (936–1013) pioneered the preparation of medicines by sublimation and distillation. His Liber servitoris is of particular interest, as it provides the reader with recipes and explains how to prepare the 'simples' from which were compounded the complex drugs then generally used. Sabur Ibn Sahl (d 869), was, however, the first physician to record his findings in a pharmacopoeia, describing a large variety of drugs and remedies for ailments. Al-Biruni (973–1050) wrote one of the most valuable Islamic works on pharmacology, entitled Kitab al-Saydalah (The Book of Drugs), in which he detailed the properties of drugs and outlined the role of pharmacy and the functions and duties of the pharmacist. Avicenna, too, described no less than 700 preparations, their properties, modes of action, and their indications. He devoted in fact a whole volume to simple drugs in The Canon of Medicine. Of great impact were also the works by al-Maridini of Baghdad and Cairo, and Ibn al-Wafid (1008–1074), both of which were printed in Latin more than fifty times, appearing as De Medicinis universalibus et particularibus by 'Mesue' the younger, and the Medicamentis simplicibus by 'Abenguefit'. Peter of Abano (1250–1316) translated and added a supplement to the work of al-Maridini under the title De Veneris. Al-Muwaffaq's contributions in the field are also pioneering. Living in the 10th century, he wrote The foundations of the true properties of Remedies, amongst others describing arsenious oxide, and being acquainted with silicic acid. He made clear distinction between sodium carbonate and potassium carbonate, and drew attention to the poisonous nature of copper compounds, especially copper vitriol, and also lead compounds. He also describes the distillation of sea-water for drinking.

In Europe, pharmacy-like shops began to appear during the 12th century. In 1240, emperor Frederic II issued a decree by which the physician's and the apothecary's professions were separated.

Sign of the Town Hall Pharmacy in Tallinn, operating continuously from at least 1422, showing the Bowl of Hygieia

There are pharmacies in Europe that have been in operation since medieval times. In Dubrovnik (Croatia), a pharmacy that first opened in 1317 is located inside the Franciscan monastery: it is oldest operating pharmacy in Europe. In the Town Hall Square of Tallinn (Estonia), there is a pharmacy dating from at least 1422. The medieval Esteve Pharmacy, located in Llívia, a Catalan enclave close to Puigcerdà, is a museum: the building dates back to the 15th century and the museum keeps albarellos from the 16th and 17th centuries, old prescription books and antique drugs.

Practice areas

Pharmacists practice in a variety of areas including community pharmacies, hospitals, clinics, extended care facilities, psychiatric hospitals, and regulatory agencies. Pharmacists themselves may have expertise in a medical specialty.

Community pharmacy

A pharmacy (also known as a chemist in Australia, New Zealand and the British Isles; or drugstore in North America; retail pharmacy in industry terminology; or apothecary, historically) is where most pharmacists practice the profession of pharmacy. It is the community pharmacy in which the dichotomy of the profession exists; health professionals who are also retailers.

Community pharmacies usually consist of a retail storefront with a dispensary, where medications are stored and dispensed. According to Sharif Kaf al-Ghazal, the opening of the first drugstores are recorded by Muslim pharmacists in Baghdad in 754 AD.

Hospital pharmacy

Pharmacies within hospitals differ considerably from community pharmacies. Some pharmacists in hospital pharmacies may have more complex clinical medication management issues, and pharmacists in community pharmacies often have more complex business and customer relations issues.

Because of the complexity of medications including specific indications, effectiveness of treatment regimens, safety of medications (i.e., drug interactions) and patient compliance issues (in the hospital and at home), many pharmacists practicing in hospitals gain more education and training after pharmacy school through a pharmacy practice residency, sometimes followed by another residency in a specific area. Those pharmacists are often referred to as clinical pharmacists and they often specialize in various disciplines of pharmacy.

For example, there are pharmacists who specialize in hematology/oncology, HIV/AIDS, infectious disease, critical care, emergency medicine, toxicology, nuclear pharmacy, pain management, psychiatry, anti-coagulation clinics, herbal medicine, neurology/epilepsy management, pediatrics, neonatal pharmacists and more.

Hospital pharmacies can often be found within the premises of the hospital. Hospital pharmacies usually stock a larger range of medications, including more specialized medications, than would be feasible in the community setting. Most hospital medications are unit-dose, or a single dose of medicine. Hospital pharmacists and trained pharmacy technicians compound sterile products for patients including total parenteral nutrition (TPN), and other medications are given intravenously. That is a complex process that requires adequate training of personnel, quality assurance of products, and adequate facilities.

Several hospital pharmacies have decided to outsource high-risk preparations and some other compounding functions to companies who specialize in compounding. The high cost of medications and drug-related technology and the potential impact of medications and pharmacy services on patient-care outcomes and patient safety require hospital pharmacies to perform at the highest level possible.

Clinical pharmacy

Pharmacists provide direct patient care services that optimize the use of medication and promotes health, wellness, and disease prevention. Clinical pharmacists care for patients in all health care settings, but the clinical pharmacy movement initially began inside hospitals and clinics. Clinical pharmacists often collaborate with physicians and other healthcare professionals to improve pharmaceutical care. Clinical pharmacists are now an integral part of the interdisciplinary approach to patient care. They often participate in patient care rounds for drug product selection. In the UK clinical pharmacists can also prescribe some medications for patients on the NHS or privately, after completing a non-medical prescribers course to become an Independent Prescriber.

The clinical pharmacist's role involves creating a comprehensive drug therapy plan for patient-specific problems, identifying goals of therapy, and reviewing all prescribed medications prior to dispensing and administration to the patient. The review process often involves an evaluation of the appropriateness of drug therapy (e.g., drug choice, dose, route, frequency, and duration of therapy) and its efficacy. The pharmacist must also consider potential drug interactions, adverse drug reactions, and patient drug allergies while they design and initiate a drug therapy plan.

Ambulatory care pharmacy

Since the emergence of modern clinical pharmacy, ambulatory care pharmacy practice has emerged as a unique pharmacy practice setting. Ambulatory care pharmacy is based primarily on pharmacotherapy services that a pharmacist provides in a clinic. Pharmacists in this setting often do not dispense drugs, but rather see patients in-office visits to manage chronic disease states.

In the U.S. federal health care system (including the VA, the Indian Health Service, and NIH) ambulatory care pharmacists are given full independent prescribing authority. In some states, such North Carolina and New Mexico, these pharmacist clinicians are given collaborative prescriptive and diagnostic authority. In 2011 the board of Pharmaceutical Specialties approved ambulatory care pharmacy practice as a separate board certification. The official designation for pharmacists who pass the ambulatory care pharmacy specialty certification exam will be Board Certified Ambulatory Care Pharmacist and these pharmacists will carry the initials BCACP.

Compounding pharmacy/industrial pharmacy

Compounding involves preparing drugs in forms that are different from the generic prescription standard. This may include altering the strength, ingredients, or dosage form. Compounding is a way to create custom drugs for patients who may not be able to take the medication in its standard form, such as due to an allergy or difficulty swallowing. Compounding is necessary for these patients to still be able to properly get the prescriptions they need.

One area of compounding is preparing drugs in new dosage forms. For example, if a drug manufacturer only provides a drug as a tablet, a compounding pharmacist might make a medicated lollipop that contains the drug. Patients who have difficulty swallowing the tablet may prefer to suck the medicated lollipop instead.

Another form of compounding is by mixing different strengths (g, mg, mcg) of capsules or tablets to yield the desired amount of medication indicated by the physician, physician assistant, nurse practitioner, or clinical pharmacist practitioner. This form of compounding is found at community or hospital pharmacies or in-home administration therapy.

Compounding pharmacies specialize in compounding, although many also dispense the same non-compounded drugs that patients can obtain from community pharmacies.

Consultant pharmacy

Consultant pharmacy practice focuses more on medication regimen review (i.e. "cognitive services") than on actual dispensing of drugs. Consultant pharmacists most typically work in nursing homes, but are increasingly branching into other institutions and non-institutional settings. Traditionally consultant pharmacists were usually independent business owners, though in the United States many now work for a large pharmacy management company such as Omnicare, Kindred Healthcare or PharMerica. This trend may be gradually reversing as consultant pharmacists begin to work directly with patients, primarily because many elderly people are now taking numerous medications but continue to live outside of institutional settings. Some community pharmacies employ consultant pharmacists and/or provide consulting services.

The main principle of consultant pharmacy is developed by Hepler and Strand in 1990.

Veterinary pharmacy

Veterinary pharmacies, sometimes called animal pharmacies, may fall in the category of hospital pharmacy, retail pharmacy or mail-order pharmacy. Veterinary pharmacies stock different varieties and different strengths of medications to fulfill the pharmaceutical needs of animals. Because the needs of animals, as well as the regulations on veterinary medicine, are often very different from those related to people, in some jurisdictions veterinary pharmacy may be kept separate from regular pharmacies.

Nuclear pharmacy

Nuclear pharmacy focuses on preparing radioactive materials for diagnostic tests and for treating certain diseases. Nuclear pharmacists undergo additional training specific to handling radioactive materials, and unlike in community and hospital pharmacies, nuclear pharmacists typically do not interact directly with patients.

Military pharmacy

Airman 1st Class Breanna DeMasters and Staff Sgt. Giovanni Fiorito, 332nd Expeditionary Medical Group pharmacy technicians, fill prescription medication for patients, Oct. 7, Joint Base Balad Iraq.

Military pharmacy is a different working environment to civilian practise because military pharmacy technicians perform duties such as evaluating medication orders, preparing medication orders, and dispensing medications. This would be illegal in civilian pharmacies because these duties are required to be performed by a licensed registered pharmacist. In the US military, state laws that prevent technicians from counseling patients or doing the final medication check prior to dispensing to patients (rather than a pharmacist solely responsible for these duties) do not apply.

Pharmacy informatics

Pharmacy informatics is the combination of pharmacy practice science and applied information science. Pharmacy informaticists work in many practice areas of pharmacy, however, they may also work in information technology departments or for healthcare information technology vendor companies. As a practice area and specialist domain, pharmacy informatics is growing quickly to meet the needs of major national and international patient information projects and health system interoperability goals. Pharmacists in this area are trained to participate in medication management system development, deployment, and optimization.

Specialty pharmacy

Specialty pharmacies supply high-cost injectable, oral, infused, or inhaled medications that are used for chronic and complex disease states such as cancer, hepatitis, and rheumatoid arthritis. Unlike a traditional community pharmacy where prescriptions for any common medication can be brought in and filled, specialty pharmacies carry novel medications that need to be properly stored, administered, carefully monitored, and clinically managed. In addition to supplying these drugs, specialty pharmacies also provide lab monitoring, adherence counseling, and assist patients with cost-containment strategies needed to obtain their expensive specialty drugs. In the US, it is currently the fastest-growing sector of the pharmaceutical industry with 19 of 28 newly FDA approved medications in 2013 being specialty drugs.

Due to the demand for clinicians who can properly manage these specific patient populations, the Specialty Pharmacy Certification Board has developed a new certification exam to certify specialty pharmacists. Along with the 100 questions computerized multiple-choice exam, pharmacists must also complete 3,000 hours of specialty pharmacy practice within the past three years as well as 30 hours of specialty pharmacist continuing education within the past two years.

Pharmaceutical sciences

The pharmaceutical sciences are a group of interdisciplinary areas of study concerned with the design, action, delivery, and disposition of drugs. They apply knowledge from chemistry (inorganic, physical, biochemical and analytical), biology (anatomy, physiology, biochemistry, cell biology, and molecular biology), epidemiology, statistics, chemometrics, mathematics, physics, and chemical engineering.

The pharmaceutical sciences are further subdivided into several specific specialties, with four main branches:

As new discoveries advance and extend the pharmaceutical sciences, subspecialties continue to be added to this list. Importantly, as knowledge advances, boundaries between these specialty areas of pharmaceutical sciences are beginning to blur. Many fundamental concepts are common to all pharmaceutical sciences. These shared fundamental concepts further the understanding of their applicability to all aspects of pharmaceutical research and drug therapy.

Pharmacocybernetics (also known as pharma-cybernetics, cybernetic pharmacy, and cyber pharmacy) is an emerging field that describes the science of supporting drugs and medications use through the application and evaluation of informatics and internet technologies, so as to improve the pharmaceutical care of patients.

Society and culture

Etymology

The word pharmacy is derived from Old French farmacie "substance, such as a food or in the form of a medicine which has a laxative effect" from Medieval Latin pharmacia from Greek pharmakeia (Greek: φαρμακεία) "a medicine", which itself derives from pharmakon (φάρμακον), meaning "drug, poison, spell" (which is etymologically related to pharmakos).

Separation of prescribing and dispensing

Separation of prescribing and dispensing, also called dispensing separation, is a practice in medicine and pharmacy in which the physician who provides a medical prescription is independent from the pharmacist who provides the prescription drug.

In the Western world there are centuries of tradition for separating pharmacists from physicians. In Asian countries, it is traditional for physicians to also provide drugs.

In contemporary time researchers and health policy analysts have more deeply considered these traditions and their effects. Advocates for separation and advocates for combining make similar claims for each of their conflicting perspectives, saying that separating or combining reduces conflict of interest in the healthcare industry, unnecessary health care, and lowers costs, while the opposite causes those things. Research in various places reports mixed outcomes in different circumstances.

The future of pharmacy

Pharmacists now go on rounds with doctors and have more patient interaction.

In the coming decades, pharmacists are expected to become more integral within the health care system. Rather than simply dispensing medication, pharmacists are increasingly expected to be compensated for their patient care skills. In particular, Medication Therapy Management (MTM) includes the clinical services that pharmacists can provide for their patients. Such services include a thorough analysis of all medication (prescription, non-prescription, and herbals) currently being taken by an individual. The result is a reconciliation of medication and patient education resulting in increased patient health outcomes and decreased costs to the health care system.

This shift has already commenced in some countries; for instance, pharmacists in Australia receive remuneration from the Australian Government for conducting comprehensive Home Medicines Reviews. In Canada, pharmacists in certain provinces have limited prescribing rights (as in Alberta and British Columbia) or are remunerated by their provincial government for expanded services such as medications reviews (Medschecks in Ontario). In the United Kingdom, pharmacists who undertake additional training are obtaining prescribing rights and this is because of pharmacy education. They are also being paid for by the government for medicine use reviews. In Scotland, the pharmacist can write prescriptions for Scottish registered patients of their regular medications, for the majority of drugs, except for controlled drugs, when the patient is unable to see their doctor, as could happen if they are away from home or the doctor is unavailable. In the United States, pharmaceutical care or clinical pharmacy has had an evolving influence on the practice of pharmacy. Moreover, the Doctor of Pharmacy (Pharm. D.) degree is now required before entering practice and some pharmacists now complete one or two years of residency or fellowship training following graduation. In addition, consultant pharmacists, who traditionally operated primarily in nursing homes, are now expanding into direct consultation with patients, under the banner of "senior care pharmacy".

In addition to patient care, pharmacies will be a focal point for medical adherence initiatives. There is enough evidence to show that integrated pharmacy based initiatives significantly impact adherence for chronic patients. For example, a study published in NIH shows "pharmacy based interventions improved patients' medication adherence rates by 2.1 percent and increased physicians' initiation rates by 38 percent, compared to the control group".

History of pharmacy in the United States

From Wikipedia, the free encyclopedia
https://en.wikipedia.org/wiki/History_of_pharmacy_in_the_United_States

The history of pharmacy in the United States is the story of a melting pot of new pharmaceutical ideas and innovations drawn from advancements that Europeans shared, Native American medicine and newly discovered medicinal plants in the New World. American pharmacy grew from this fertile mixture, and has impacted U.S. history, and the global course of pharmacy.

A living historian interprets a 19th-century apothecary shop for visitors, Old Salem, North Carolina.

Apothecary—an ancient title that, especially in pre-modern or early modern contexts, indicates a broader set of skills and duties than the core role of dispensing medications, like prescribing remedies and even giving some treatments difficult to self-administer, e.g. enemas—have largely been within the "pharmacist" umbrella in the U.S. since the mid-19th century, when Edward Parrish of the American Pharmaceutical Association successfully proposed that the APhA "consider all the varied pharmaceutical practitioners 'pharmacists'” to better "standardize the field." Unlike in the UK, where pharmacists were separated from apothecaries by Parliament and the pharmacist had effectively eclipsed the ancient apothecary, appellations and professions have been far more fluid and overlapping in the U.S., especially prior to the regulatory schemes widely adopted in the late 19th century. "Apothecary" still crops up as synonym for pharmacist, along with "druggist," and has yet to fall entirely out of use, with some in the U.S. still calling themselves apothecaries. As the pharmacist increasingly became the distinct discipline and tightly defined profession it is today, American pharmacists added their own discoveries and innovations, and played a prominent role in the revolution in medical knowledge in the 19th and 20th centuries and the subsequent development of modern medicine.

The history of pharmacy has lagged behind other fields in the history of science and medicine, perhaps because primary sources in the field are sparse. Historical inquiries in this area have been few, and unlike the growing number of programs in the history of medicine, history of pharmacy programs remain few in number in the United States.

Colonial period

Early developments alongside colonization

As soon as Columbus started his explorations of the Americas in the late 15th century, a European effort to find valuable medicinal plants among the flora of the New World to add to the medical canon got underway. Early New World medicines uncovered included guaiacum from the West Indies (for coughs, rheumatism and a wide variety of other uses), sassafras from Florida, copaiba from Brazil, Peru balsam and, most famously, cinchona bark from Peru, also called "Jesuit's bark" in honor of its discoverer, which became the first effective treatment for malaria. The active ingredient of this cinchona bark, quinine, was the primary treatment for malaria well into the 1940s. "About 170 drugs used by the Indians of British North America, and perhaps 50 used by the indigenous people of the Caribbean, Mexico, Central and South America" became important enough in the U.S. (as the practitioners of chemistry and pharmacy eventually catalogued, analyzed and understood them) to merit listing in the United States Pharmacopoeia (est. 1820) or the National Formulary.

In the early 1700s, James Oglethorpe, founder of the Georgia colony, with the financial backing of the Worshipful Society of Apothecaries of London and others, launched an effort to identify and transplant beneficial plant species from the tropical colonies to Savannah, Georgia. Unfortunately for Oglethorpe (and all the Southern colonists) the expedition that marked this first attempt by an organized group of Old World apothecaries to benefit from British North America's potential as a medicine farm never bore fruit. The Caribbean expedition's lead investigator, botanist Robert Miller, was hampered by illness and uncooperative Spanish colonials, and all support from London ceased when Miller died without much success.

Pharmacy in eighteenth-century North America

The first "drugstores" in North America "appeared in Bethlehem, Pennsylvania, Boston, New York, and Philadelphia," with likely proto-drugstores—for example Gysbert van Imbroch ran a "general store" that sold drugs from 1663 to 1665 in Wildwyck, New Netherland, today's Kingston, New York—preceding the dedicated apothecary shops of the 1700s, and providing a model. Because of that model, and customs that stretch back to the first apothecary shops in the medieval Arab world most drugstores continued selling more general goods, perfumes, cosmetics, and drinks of all sorts alongside medicines, and still do.

Non-British influences

That the Spanish colonials, not the British, were the first in North America to license a pharmacist (in 1769 in New Orleans) and were also the first to regulate pharmacy as a separate profession, points to the importance of non-British colonial governments and, indeed, settlers from mainland Europe throughout North America, in importing and translating the more modern pharmacy methods, standards and ways of organization and regulation—developing in Europe since at least the 1600s—for application in the infant United States.

"Franco-Spanish" Louisiana "more clearly reflected [pharmacy's] development in Continental Europe." Influential milestones achieved in 18th-century Louisiana included the February 12th, 1770 edict from the governor in New Orleans, Don Alexandre O'Reilly, delineating the responsibilities and boundaries of medicine, surgery and pharmacy and marking the first legal recognition of pharmacy as a distinct discipline in the territories that would become the United States. Though the number of pharmacists licensed under this system in Spanish Louisiana never surpassed the single-digits, O'Reilly's decree and its ethical code for pharmacists set an important precedent future developments would build upon. It also brought on-line an important independent pipeline of licensed druggists, albeit a small pipeline, to add to the scant supply of Old World apothecaries who had immigrated to set up shop in the colonies.

Of the few apothecaries imported from Europe, those of Jesuit training had a long-felt impact in both New Spain and New France; so great was Jesuit involvement in "care of the sick" in their foreign missions, in fact, they sought and received a papal exemption from the ban on clerics serving in medical roles. Two dedicated "pharmacopoles or apothecary brethren" Jesuits are listed under the heading "Missions of North America in New France" in Society of Jesus personnel records for the "Province of France at the End of the Year 1749." Jesuit contributions, especially in translating Native American ethnobotany into medicines for European use, were highly influential as pharmacy developed in North America.

In British North America

Pharmacist Ambrose Hunsberger, in his sweeping introduction covering pharmacy's development in the United States prior to the events discussed in his 1923 article on Prohibition's impact, "The Practice of Pharmacy Under the Volstead Act," described pharmacy before its organization (which he places around 1821) in terms that evoke the snake oil salesmen and medicine shows that hit every town, hamlet and village in the country: "...the disorganized system of hawking medicinal remedies which prevailed throughout our thinly populated country. There was no method of protecting the public from fraud through control or regulation of the sale of adulterated and harmful medicinal products, and the credulous citizenry of the young nation was beguiled by every description of fakir and charlatan into buying their fantastic panaceas." Hunsberger puts the practice of "more or less methodical" pharmacy in Europe "two or three centuries" back, as early as the 16th or 17th centuries, whereas he places the start of organized pharmacy in the United States with the founding of America's first formal college of pharmacy, the Philadelphia College of Pharmacy (PCP), in 1821.

Prior to this, however, the original British colonies retained a much more ad hoc, improvisational approach to pharmacy, and "there were, as was to be expected in a land so vast and so sparsely settled, virtually no limitations as to where or by whom pharmacy could be practiced." Lines between the professions of pharmacist, wholesale druggist and physician did not yet exist in the way they would later; "their provinces overlapped, and appellations, which often meant little, frequently changed."

An empty bottle of True Daffy's Elixir (center) Dicey and Co.
Dicey and Co.'s True Daffy's Elixir, its 18th century-type embossed medicine bottle seen here (center), was one of the more popular examples of the patent medicines Americans imported from across the Atlantic in the 18th and 19th centuries.

In the colonial and early independence years, necessity demanded a do-it-yourself approach to pharmacy. "Most, if not all, American medical men prepared and dispensed their own medications, since fee bills and custom usually provided fees for the medication and not the visit, unless surgery or delivery was involved." Thus, oftentimes the doctor was the apothecary and the apothecary the doctor, especially among rural "country doctors" who predominated in this era of farmers with "freeholds" thinly dotting the colonies. "Even in the 1760s, when a younger and largely native born cohort of physicians returned from Europe, most of the reputable and even famous among the American medici ran their own pharmaceutical business," which, for most doctors for the bulk of the 18th century included mostly medications mixed and dispensed by hand, sometimes augmented with a supply of patent medicines imported from the UK or mainland Europe.

In the cities, the foundations of commercial pharmacy were slowly building. By 1721 there were "14 apothecary shops in Boston," and the first "commissioned pharmaceutical officer in an American army" was the Boston apothecary, Andrew Craigie. A sort of warrior-apothecary, he took part in the Battle of Bunker Hill, June 17, 1775. And "when Congress reorganized the Medical Department of the Army in 1777, Craigie became the first Apothecary General."

An engraving depicting an 18th-century chemical laboratory, from William Lewis' later work Commercium Philosophico-Technicum (mid-1760s)

Important early American "apothecary shops" include the one in colonial Fredericksburg run by later-brigadier general in the Continental Army, Hugh Mercer, (the building is now a museum, and has been "scientifically dated" to 1771 or 1772). And the Marshall Apothecary (established 1729, open for 96 years) in Philadelphia, which was a manufacturer of medicines as well as a retailer, and served as an important supplier throughout the Revolutionary War. Advertisements from the period indicate "that there were drugstores in virtually all American cities by the end of the eighteenth century."

Economic historian Bernice Hamilton describes the 1700s as having "completely transformed" all "the medical professions," explaining that "advances in medical education and science," the emergence of a robust middle class, "as well as the growth of 'a professional feeling'" had greatly changed the socio-economic order by the end of the 18th century. Thanks to the ruling in the Rose Case back in London, apothecaries began 1705 as fully accredited medical professionals who could write prescriptions. Hamilton notes "…the apothecaries, once mere tradesmen and the 'servants of the physician,' had become practicing doctors," treating patients directly. These trends spread to the colonies, and though apothecaries never organized into a legally distinct and guilded profession in North America, the rural hinterlands mirrored the prevalence of the apothecary in Britain, where "in more remote locales, the apothecary 'was usually the only doctor.'"

The pharmacopoeia, which simply lists useful drugs—or sometimes more importantly, drops questionable substances from the canon—"came fully into its own in the early modern age", encompassing roughly the span of history covering the 1500s up until the French Revolutions in the late 1700s. But pharmacopoeias mainly offered some basics and compounding instructions.

Not until the first dispensatories were there books disseminating more comprehensive information on pharmaceuticals: guidance on uses for drugs, how and in what situations to employ them, experience with best practices, etc. "This kind of book, the dispensatory, became something of a British specialty in the late seventeenth and eighteenth century." These dispensatories, chief among them William Lewis' The New Dispensatory, which debuted in 1753 and was regarded as "the first truly scientific work on pharmacy in the English language," along with a later (1786) book intended as "'an improvement' on Lewis," the Edinburgh New Dispensatory, were undoubtedly formative for pharmacy in British North America. The New Dispensatory and Edinburgh New Dispensatory were printed in many editions and numerous languages within their lifespans (1753-1830) including six printings for American use between them.'

The 19th century: American pharmacy emerges

The 19th century (1800s) birthed "pharmacy as we know it." And again, pharmacy's development in mainland Europe continued to fuel its growth in the young American republic.

The Philadelphia College of Pharmacy and the birth of organized American pharmacy

The Philadelphia College of Pharmacy (PCP), modeled—at least in concept—after the Collége de pharmacie in Paris, was aided by European talent in its early, formative years. Elias Durand, who had served as "pharmacien of the Grand Army of Napoleon I," set up shop in Philadelphia in 1825, and "...in connection with the Philadelphia College of Pharmacy, immediately exerted a strong foreign influence on American pharmacy." According to William Procter, Jr., Durand "directly and indirectly had much to do with the introduction of scientific pharmacy into Philadelphia." Without teaching at the college, Durand still had a big impact by spreading new findings about medicinal plants, making "medicinal chemicals" never before created in the U.S., by training apprentices, like Augustine Duhamel, who went on to make important contributions and publish in the college journal, and by serving as a role model for foundational figures like Procter.

Hunsberger cites the founding of the Philadelphia College of Pharmacy (PCP) as "the first step forward in the development of a system of pharmaceutical practice in the United States," with the 1821 "meeting of apothecaries...held in Carpenters' Hall" (where the Declaration of Independence had been signed) to set up the first formal college of pharmacy and first pharmacists' association (the Philadelphia College of Pharmacy) in North America the seminal founding event. On March 13, 1821, "Sixty-eight pharmacists signed the Constitution of the first pharmaceutical association in the United States," with the symbolism of the Carpenters' Hall backdrop undeniable: American pharmacy would have a constitution, following in the footsteps of the founding fathers and their constitutional framework. The PCP constitution included a strict code of ethics that would expel anyone from the college who "adulterated" medications or knowingly sold "articles of that character," and provided for a "committee of inspection" to verify the purity, safety and effectiveness of medicines, and a "committee of equity" to arbitrate disputes between member pharmacists. The college, which was founded as an association to advance the discipline of pharmacy not just a university, quickly became a game-changer: in 1824 they published "carefully determined formulas" for the fabrication of (formerly) "secret-formula" patent medicines previously imported from the UK, an essential step toward self-sufficient pharmaceutical manufacturing in the U.S.

The Philadelphia College of Pharmacy also aided the rise of the American Pharmaceutical Association (APhA), which formed at a founding convention congregated in the Hall of the College, October 6 to 8, 1852. Daniel B. Smith, who had long been the PCP's president—ultimately from 1829 to 1854—was elected the APhA's first president at the founding convention, and William Procter, Jr. the first secretary.

The "Father of American Pharmacy"

William Procter, Jr., who graduated from, then taught at the Philadelphia College of Pharmacy for 20 years, went on to exert so much influence over the formative years of professional pharmacy that he's now widely considered the "Father of American Pharmacy." Procter successfully argued for the establishment of a chair of Pharmacy for pharmacist-professors at the PCP in 1844, then wrote "the first American pharmacy textbook," which came to be known as Mohr, Redwood, and Procter's Practical Pharmacy (1849). The book was not commercially successful, but became a model for subsequent "works of long-lived popularity: Edward Parrish's An Introduction to Practical Pharmacy (1855-1884), and Joseph P. Remington's Practice of Pharmacy (1888-1995 [19th ed.])". Procter also led the American Journal of Pharmacy for 22 years, served 30 years on the U.S.P. Revision Committee, where he did much to improve the U.S. Pharmacopeia, and following five years as the American Pharmaceutical Association's corresponding secretary, he became the APhA's president, leading delegations of American pharmacists in conferences with their counterparts offshore. At the Second International Congress of Pharmacy in Paris, France, August 21 to 24, 1867, Procter argued forcefully against the "compulsory limitation of pharmacies" (capping their number in a given city or province) under consideration, telling the assembled delegates that, in the U.S., "there is not the slightest obstacle toward a multiplication of drug stores save that a lack of success" and that the American public is "a forceful agent of reform" to keep unscrupulous operators in check. Procter's declaration was later seen as a defining statement of "the American Way of Pharmacy."

Pharmacy schools and professional organizations spread

Other major cities on the Eastern Seaboard followed Philadelphia's lead, establishing university training programs, professional associations and colleges of pharmacy that acted as professional associations like the PCP. New York City was among the quickest to follow suit with the New York College of Pharmacy, established 1829.

As this 1851 notice from the New York Daily Times exemplifies, pharmacy schools (here the New York College of Pharmacy) often were acting as professional associations, or at least promoted pharmacist education and the distinct profession of pharmacist with a guild-like zeal, with this article advertising training for "those who desire to qualify themselves thoroughly as Apothecaries" while calling out "inferior druggists" and cautioning that "community ought not to be indifferent" to the character and motives of druggists who "stand aloof from the College." Note the use of the term "druggists" to denote medication providers who are not trained pharmacists, while the term "apothecary" is still used as positive synonym.

1860 The first Pharmacists arrive on the west coast of America in the newly formed state of California

The Dr. Wilson Foskett Home and Drugstore, opened c. 1897 and now a registered National Historic Place in Idaho County, Idaho, shows how pharmaceutical businesses run by a doctor in conjunction with their medical practice, a ubiquitous feature of medicine in 1700s North America, persisted in more rural areas during the 19th century, sometimes even into the 20th century.

Although the "modern" form of pharmacy was well into its development by the beginning of the 1800s on the east coast and other areas to the west of America, it would take several decades until 1847 before America would finally have control over the furthest south-western continental territories. Although there were several legitimate American doctors in Los Angeles by 1850, none of whom had studied or held degrees in the pharmaceutical sciences, in particular (pharmaceutical formulation) but nonetheless subsequently functioned as "druggist" and as an interesting side note, almost all of whom were not primarily doctors as a main occupation but had other main forms of livelihoods. In ca. 1854 one such case, and also one of the first doctors in L.A., Dr. William B. Osborn (sometimes spelled as Osburn, Osbourne, or Osbourn), also credited as being the first "drug-store" establisher in Los Angeles, had turned his business over (to pursue other non-medical endeavors) to Dr. James P. McFarland and John Gately Downey. The store then under the control of the partnership between McFarland and Downey was then actually run by a Dr. Alexander Hope also a "druggist" as more of an employee of the two men. Downey had previously only apprenticed at an apothecary in Washington, D.C., until 1846 and later worked as an independent "druggist" in Cincinnati, Ohio, before finally arriving in California in 1849. Once in Los Angeles, Downey's main focus and foremost career ambition was mainly that of a politician rather than that of a schooled, professional apothecary or pharmacist. In 1856 Dr. McFarland had also left the business partnership and California to return home to Tennessee. Downey eventually sold the "drug-store" to Dr. Henry M. Myles and C.M. Small (in order to further pursue his true vocation in politics and go on to become the seventh Governor of California from 1860 to 1862) and shortly thereafter Dr. Myles passed away and a German immigrant, pharmacist had taken the business over. It was not until ca. 1860, which saw the first of two European, immigrant, career pharmacists / apothecaries (both of German descent) who arrived in the newly founded American frontier town of Los Angeles, California. The first was the pharmacist Theodore Wollweber (Main St. / Hall at 59) and in 1861 his only competitor at the time, the second pharmacist Adolph Junge, who also established his "drug store" in the same Temple Block (Temple Street) area on 99 Main-St. north of Commercial St. and was in operation for about 20 years thereafter until ca. 1880. The future medical pioneer Dr. Joseph Kurtz (German) arrived in L.A. in 1868 at the encouragement and recommendation of close associate Adolph Junge and would go on to be the first Los Angeles County Medical Examiner - Coroner from 1870 to 1873 and again from 1876 to 1877 in addition to being one of the founders of the Los Angeles County Medical Association in 1871 and the professor of surgery at USC School of Medicine (founded in 1885 and in 1999 renamed as Keck School of Medicine of USC) for 25 years, from 1885 to 1910. Also, the later locally well-known (German) pharmacist F.J. Gieze came to work as a clerk and colleague following in 1874 for a time thereafter with Junge, and would later gain recognition as a trusted pharmacist. Around this same time period a Dr. J.M. Jansco (who specialized in "Diseases of Children") pediatrician had his practice located at Junge's drug-store as well as Dr. Osborn who had also maintained his office at Junge's drug-store from 1865 until his death in 1867. The original prescription book of pharmacist Adolph Junge bears historical witness to his activity and can still be viewed / researched today in the Natural History Museum of Los Angeles County (as part of the "Prudhomme Papers" Archives). The USC College of Pharmacy was established in 1905. Since the arrival of the first two European-schooled pharmacists in 1860, Wollweber and Junge, it would then take some 60+ years longer for the retail pharmacy industry as a whole to further develop, "when in 1919 brothers Harry and Robert Borun, along with brother-in-law Norman Levin, founded Borun Brothers, a Los Angeles drug wholesaler". Following 10 years later, in 1929, the brothers opened their own Los Angeles retail outlets under the name Thrifty Cut Rate, which would shortly thereafter be renamed to Thrifty Drug Store and in turn would usher in the age of the modern "drug, sundries & household wares" chain-store model with hired/contracted professional in-house pharmacists. The first store was located at 412 S. Broadway in downtown Los Angeles, just across the street from the original Broadway Department Store. By 1942, they operated 58 chain stores in and around the greater Los Angeles area, which also served as a business model that most all other large corporate drug store chains would follow.

Pharmacy and the Industrial Revolution

With the rise of mechanization and mass production, new modes of medication-delivery, among them the tablet (1884), the enteric-coated pill (1884) and the gelatin capsule (first produced on a large scale in 1875 by Parke, Davis & Company, Detroit) became practicable. By 1900, most pharmacies stocked the shelves, partially or predominantly, with medicines prefabricated en masse by the growing pharmaceutical industry instead of custom-produced by individual pharmacisti, and the traditional role of the scientifically trained pharmacist to produce medicines increasingly eroded. This shift worried many, raising concerns of quality control, professional irrelevance and more. William Procter lamented that, "If the pharmacist becomes a mere dispenser of medicines, 'he relapses into a simple shopkeeper.'”

At the "London Chemists" drugstore at Eighth Avenue and 23rd Street in Manhattan, many foods and medicines are advertised, including Ex-lax. Photo taken following the gangland killing of Mad Dog Coll, who was using the drugstore phone booth, February 8th, 1932.
 
"Soda jerks" dispensing Coca-Cola at Fleeman's Pharmacy, Atlanta, Georgia, circa 1948. This photo documents the first-ever installation of this model of "Boat Motor"-styled Coca-Cola dispenser.

21st century developments

Background

By the turn of the 21st century, several factors gave rise to concerns about a shortage of primary care in the United States. From an aging generation of baby boomers to increasing numbers of physician retirees, it was projected that the United States would be short about 40,000-52,000 physicians by the 2020s. Furthermore, "implementation of the Affordable Care Act identifies millions of newly insured patients needing primary care." This shortage was viewed by many as an opportunity to expand the scope of practice of existing healthcare professionals, such as pharmacists.

Provider status

On the federal level, legislation regarding pharmacists' provider status was first introduced to the U.S. House of Representatives in 2014 by Representative Brett Guthrie (R-KY) in the 113th Congress. The purpose of the Pharmacy and Medically Underserved Areas Enhancement Act (HR 592) was to amend the Social Security Act to recognize pharmacists as healthcare providers and cover their services in medically underserved communities under Medicare Part B. This bill failed to pass and was reintroduced in 2015 by Representatives Brett Guthrie (R-KY), G.K. Butterfield (D-NC), and Todd Young (R-IN). Unfortunately, this bill expired once more at the end of the 114th Congress. It was reintroduced for the third time on Jan 12, 2017 during the 115th Congress by Representatives Sherrod Brown (D-OH), Bob Casey (D-PA), and Chuck Grassley (R-IA). The bill was referred to the Committee on Finance but was not enacted.

A number of states are expanding the pharmacist's scope of practice through the implementation of advanced practice pharmacy. In addition to the advanced practice designation, pharmacists in certain practice settings have been granted the ability to perform certain tasks under a collaborative practice agreement (CPA) with a physician. These tasks include the following:

  • Assess the patient by gathering subjective and objective information
  • Prescribe medications to manage disease states (starting, stopping, or adjusting treatment)
  • Order lab tests and interpret the results
  • Coordinate patient care with other healthcare professionals
  • Develop relationships with patient to allow for ongoing care

Under this movement for expansion of pharmacists' scope of practice, the state of California instated Senate Bill 493 in 2014, written by Senator Ed Hernandez, authorizing pharmacists to furnish self-administered hormonal contraceptives, nicotine replacement products, and prescription medications recommended for international travelers not requiring a diagnosis, among other functions. The bill also authorized California-licensed pharmacists to order tests pertaining to the efficacy and safety of patient drug therapies as well as performing patient assessments. This bill was followed by Assembly Bill 1535 in 2014, granting California pharmacists the authority to furnish naloxone. As an adjunct to SB493 and AB1535, Assembly Bill 1114 was approved in California in 2016 to establish a fee schedule for pharmacist services under the Medi-Cal program, allowing for proper reimbursement of the following provided or furnished services:

In 2019, the California Department of Health Care Services (DHCS) established the fee schedule for AB1114, issuing the billing codes needed to implement the pharmacy services outlined by the bill. Under AB 1114, pharmacists may bill for services using CPT code 99201 for new patients, CPT code 99212 for established patients, or CPT code 90471 for immunization administration.

Women in pharmacy in the United States

Elizabeth Gooking Greenleaf was the first female apothecary in the Thirteen Colonies. She is considered to be the first female pharmacist in the United States.

Mary Corinna Putnam Jacobi graduated from the New York College of Pharmacy in 1863, which made her the first woman to graduate from a United States school of pharmacy.

Susan Hayhurst was the first woman to receive a pharmacy degree in the United States, which occurred in 1883.

Cora Dow (1868–1915), a pharmacist in Cincinnati, Ohio, was the leading female pharmacist of her time, with eleven stores under her name when she died.

Julia Pearl Hughes (1873-1950) was the first African-American female pharmacist to own and operate her own drug store.

Anna Louise James (1886-1977) was the first African-American female pharmacist in Connecticut.

History of pharmacy

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The history of pharmacy as an independent science dates back to the first third of the 19th century. Before then, pharmacy evolved from antiquity as part of medicine. The history of pharmacy coincides well with the history of medicine, but it's important that there is a distinction between the two topics. Pharmaceuticals is one of the most-researched fields in the academic industry, but the history surrounding that particular topic is sparse compared to the impact its made world-wide. Before the advent of pharmacists, there existed apothecaries that worked alongside priests and physicians in regard to patient care.

Pharmacy in Rome, Italy

Prehistoric Pharmacy

Paleopharmacological studies attest to the use of medicinal plants in pre-history. For example, herbs were discovered in the Shanidar Cave, and remains of the areca nut (Areca catechu) in the Spirit Cave. Prehistoric man learned pharmaceutical techniques through instinct, by watching birds and beasts, and using cool water, leaves, dirt, or mud as a soothing agent.

Antiquity

Mesopotamia and Egypt

Sumerian cuneiform tablets record prescriptions for medicine. Ancient Egyptian pharmacological knowledge was recorded in various papyri such as the Ebers Papyrus of 1550 BC and it included a 1,100-page document about 800 prescriptions using 700 drugs mostly derived from plants, and the Edwin Smith Papyrus of the 16th century BC.

The very beginnings or pharmaceutical texts were written on clay tablets by Mesopotamians. Some texts included formulas, instructions via pulverization, infusion, boiling, filtering and spreading; herbs were mentioned as well. Babylon, a state within Mesopotamia, provided the earliest known practice of running an apothecary i.e. pharmacy. Alongside the ill person included a priest, physician, and a pharmacist to tend to their needs.

Greece

Dioscorides, De Materia Medica, Byzantium, 15th century

In Ancient Greece, there existed a separation between physician and herbalist. The duties of the herbalist was to supply physicians with raw materials, including plants, to make medicines. According to Edward Kremers and Glenn Sonnedecker, "before, during and after the time of Hippocrates there was a group of experts in medicinal plants. Probably the most important representative of these rhizotomoi was Diocles of Carystus (4th century BC). He is considered to be the source for all Greek pharmacotherapeutic treatises between the time of Theophrastus and Dioscorides."

From 60 and 78 AD, the Greek physician Pedanius Dioscorides wrote a five volume book, De Materia Medica, covering over 600 plants and coining the term materia medica. It formed the basis for many medieval texts, and was built upon by many middle eastern scientists during the Islamic Golden Age.

Asia

The earliest known Chinese manual on materia medica is the Shennong Bencao Jing (The Divine Farmer's Herb-Root Classic), dating back to the first century AD. It was compiled during the Han dynasty and was attributed to the mythical Shennong. Earlier literature included lists of prescriptions for specific ailments, exemplified by a manuscript "Recipes for 52 Ailments", found in the Mawangdui, sealed in 168 BC. Further details on Chinese pharmacy can be found in the Pharmacy in China article.

The earliest known compilation of medicinal substances in Indian traditional medicine dates to the third or fourth century AD )(attributed to Sushruta, who is recorded as a physician of the sixth century BC).

There is a stone sign for a pharmacy with a tripod, a mortar, and a pestle opposite one for a doctor in the Arcadian Way in Ephesus, Turkey.

In Japan, at the end of the Asuka period (538-710) and the early Nara period (710-794), the men who fulfilled roles similar to those of modern pharmacists were highly respected. The place of pharmacists in society was expressly defined in the Taihō Code (701) and re-stated in the Yōrō Code (718). Ranked positions in the pre-Heian Imperial court were established; and this organizational structure remained largely intact until the Meiji Restoration (1868). In this highly stable hierarchy, the pharmacists—and even pharmacist assistants—were assigned status superior to all others in health-related fields such as physicians and acupuncturists. In the Imperial household, the pharmacist was even ranked above the two personal physicians of the Emperor.

Middle Ages

Middle East

In Baghdad the first pharmacies, or drug stores, were established in 754, under the Abbasid Caliphate during the Islamic Golden Age. By the ninth century, these pharmacies were state-regulated.

Roman herbal medicine guidebook De Materia Medica of Dioscorides. Cumin & dill. c. 1334.

The advances made in the Middle East in botany and chemistry led medicine in medieval Islam substantially to develop pharmacology. Muhammad ibn Zakarīya Rāzi (Rhazes) (865-915), for instance, acted to promote the medical uses of chemical compounds. Abu al-Qasim al-Zahrawi (Abulcasis) (936-1013) pioneered the preparation of medicines by sublimation and distillation. His Liber servitoris is of particular interest, as it provides the reader with recipes and explains how to prepare the "simples" from which were compounded the complex drugs then generally used. Sabur Ibn Sahl (d. 869), was, however, the first physician to initiate a pharmacopoeia, describing a large variety of drugs and remedies for ailments. Al-Biruni (973-1050) wrote one of the most valuable Islamic works on pharmacology entitled Kitab al-Saydalah (The Book of Drugs), where he gave detailed knowledge of the properties of drugs and outlined the role of pharmacy and the functions and duties of the pharmacist. Ibn Sina (Avicenna), too, described no less than 700 preparations, their properties, mode of action and their indications. He devoted in fact a whole volume to simple drugs in The Canon of Medicine. Of great impact were also the works by al-Maridini of Baghdad and Cairo, and Ibn al-Wafid (1008–1074), both of which were printed in Latin more than fifty times, appearing as De Medicinis universalibus et particularibus by `Mesue' the younger, and the Medicamentis Simplicibus by `Abenguefit'. Peter of Abano (1250–1316) translated and added a supplement to the work of al-Maridini under the title De Veneris. Al-Muwaffaq's contributions in the field are also pioneering. Living in the tenth century, he wrote The Foundations of the True Properties of Remedies, amongst others describing arsenious oxide, and being acquainted with silicic acid. He made clear distinction between sodium carbonate and potassium carbonate, and drew attention to the poisonous nature of copper compounds, especially copper vitriol, and also lead compounds. He also describes the distillation of sea-water for drinking.

Illustration of a pharmacy in the Italian Tacuinum sanitatis, 14th century.

Europe

Old pharmacy in the Franciscan Monastery, Dubrovnik

After the fifth century fall of the Western Roman Empire, medicinal knowledge in Europe suffered due to the loss of Greek medicinal texts and a strict adherence to tradition, although an area of Southern Italy near Salerno remained under Byzantine control and developed a hospital and medical school, which became famous by the 11th century.

In the early 11th century, Salerno scholar Constantinos Africanus translated many Arabic books into Latin, driving a shift from Hippocratic medicine towards a pharmaceutical-driven approach advocated by Galen. In medieval Europe, monks typically did not speak Greek, leaving only Latin texts such as the works of Pliny available until these translations by Constantinos. In addition, Arabic medicine became more widely known due to Muslim Spain.

In the 15th century, the printing press spread medicinal textbooks and formularies; the Antidotarium was the first printed drug formulary.

In Europe pharmacy-like shops began to appear during the 12th century. In 1240 emperor Frederic II issued a decree by which the physician's and the apothecary's professions were separated.

Old pharmacies continue to operate in Dubrovnik, Croatia located inside the Franciscan monastery, opened in 1317. The Town Hall Pharmacy in Tallinn, Estonia, which dates back to at least 1422, is the oldest continuously run pharmacy in the world still operating in the original premises.

The trend towards pharmacy specialization started to take effect in Bruges, Belgium where a new law was passed that forbid physicians to prepare medications for patients.

The oldest pharmacy is claimed to be set up in 1221 in the Church of Santa Maria Novella in Florence, Italy, which now houses a perfume museum. The medieval Esteve Pharmacy, located in Llívia, a Spanish enclave close to Puigcerdà, is also now a museum dating back to the 15th century, keeping albarellos from the 16th and 17th centuries, old prescription books and antique drugs. Florence is also the birthplace of the first official pharmacopeia, called the Nuevo Receptario, in which all pharmacies would use that document as guidance for caring for the sickly.

The Royal College of Apothecaries of the City and Kingdom of Valencia was founded in 1441, considered the oldest in the world, with full administrative and legislative powers. The apothecaries of Valencia were the first in the world to elaborate their medicines, with the same criteria that are currently required in the official pharmacopoeias.

The Republic of Venice was the first State with health modern policies which requires that the nature of the drug is public. In actuality, thirteen secrets survive which were offered to sale to the Venetian Republic.

Industrialization

The 1800s brought increased technical sophistication. By the late 1880s, German dye manufacturers had perfected the purification of individual organic compounds from tar and other mineral sources and had also established rudimentary methods in organic chemical synthesis.

Ritalin-SR-20mg-full.jpg

Chloral hydrate was introduced as a sleeping aid and sedative in 1869. Chloroform was first used as an anesthetic in 1847.

Derivatives of phenothiazines had an important impact on various aspects of medicine, beginning with methylene blue which was originally used as a dye after its synthesis from aniline in 1876. Phenothiazines were used as antimalarials, antiseptics, and antihelminthics up to 1940. 1950, chlorpromazine was discovered, which began the "psychopharmacological revolution".

The United States formed the American Pharmaceutical Association in 1852 with its main purpose to advance pharmacists' roles in patient care, assist in furthering career development, spread information about tools and resources, and raising awareness about the roles of pharmacists and their contribution to patient care.

Frederick Banting and Charles Best found the hormone insulin to lower blood sugar of dogs in 1921. This inspired further work by James B. Collip who developed pure insulin used for human testing and dramatically changed the prospects for all diabetics.

Alexander Fleming developed the first antibiotic, penicillin, after discovering a fungus that was able to kill off bacteria.

 

Ethnobotany

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The ethnobotanist Richard Evans Schultes at work in the Amazon (~1940s)

Ethnobotany is the study of a region's plants and their practical uses through the traditional knowledge of a local culture and people. An ethnobotanist thus strives to document the local customs involving the practical uses of local flora for many aspects of life, such as plants as medicines, foods, intoxicants and clothing. Richard Evans Schultes, often referred to as the "father of ethnobotany", explained the discipline in this way:

Ethnobotany simply means ... investigating plants used by societies in various parts of the world.

Since the time of Schultes, the field of ethnobotany has grown from simply acquiring ethnobotanical knowledge to that of applying it to a modern society, primarily in the form of pharmaceuticals. Intellectual property rights and benefit-sharing arrangements are important issues in ethnobotany.

History

Plants have been widely used by Native American healers, such as this Ojibwa man.

The idea of ethnobotany was first proposed by the early 20th century botanist John William Harshberger. While Harshberger did perform ethnobotanical research extensively, including in areas such as North Africa, Mexico, Scandinavia, and Pennsylvania, it was not until Richard Evans Schultes began his trips into the Amazon that ethnobotany become a more well known science. However, the practice of ethnobotany is thought to have much earlier origins in the first century AD when a Greek physician by the name of Pedanius Dioscorides wrote an extensive botanical text detailing the medical and culinary properties of "over 600 mediterranean plants" named De Materia Medica. Historians note that Dioscorides wrote about traveling often throughout the Roman empire, including regions such as "Greece, Crete, Egypt, and Petra", and in doing so obtained substantial knowledge about the local plants and their useful properties. European botanical knowledge drastically expanded once the New World was discovered due to ethnobotany. This expansion in knowledge can primarily be attributed to the substantial influx of new plants from the Americas, including crops such as potatoes, peanuts, avocados, and tomatoes. The French explorer Jacques Cartier learned a cure for scurvy (a tea made from the needles of a coniferous tree, likely spruce) from a local Iroquois tribe.

Medieval and Renaissance

During the medieval period, ethnobotanical studies were commonly found connected with monasticism. Notable at this time was Hildegard von Bingen. However, most botanical knowledge was kept in gardens such as physic gardens attached to hospitals and religious buildings. It was thought of in practical use terms for culinary and medical purposes and the ethnographic element was not studied as a modern anthropologist might approach ethnobotany today.

Age of Reason

In 1732 Carl Linnaeus carried out a research expedition in Scandinavia asking the Sami people about their ethnological usage of plants.

The age of enlightenment saw a rise in economic botanical exploration. Alexander von Humboldt collected data from the New World, and James Cook's voyages brought back collections and information on plants from the South Pacific. At this time major botanical gardens were started, for instance the Royal Botanic Gardens, Kew in 1759. The directors of the gardens sent out gardener-botanist explorers to care for and collect plants to add to their collections.

As the 18th century became the 19th, ethnobotany saw expeditions undertaken with more colonial aims rather than trade economics such as that of Lewis and Clarke which recorded both plants and the peoples encountered use of them. Edward Palmer collected material culture artifacts and botanical specimens from people in the North American West (Great Basin) and Mexico from the 1860s to the 1890s. Through all of this research, the field of "aboriginal botany" was established—the study of all forms of the vegetable world which aboriginal peoples use for food, medicine, textiles, ornaments and more.

Development and application in modern science

The first individual to study the emic perspective of the plant world was a German physician working in Sarajevo at the end of the 19th century: Leopold Glück. His published work on traditional medical uses of plants done by rural people in Bosnia (1896) has to be considered the first modern ethnobotanical work.

Other scholars analyzed uses of plants under an indigenous/local perspective in the 20th century: Matilda Coxe Stevenson, Zuni plants (1915); Frank Cushing, Zuni foods (1920); Keewaydinoquay Peschel, Anishinaabe fungi (1998), and the team approach of Wilfred Robbins, John Peabody Harrington, and Barbara Freire-Marreco, Tewa pueblo plants (1916).

In the beginning, ethonobotanical specimens and studies were not very reliable and sometimes not helpful. This is because the botanists and the anthropologists did not always collaborate in their work. The botanists focused on identifying species and how the plants were used instead of concentrating upon how plants fit into people's lives. On the other hand, anthropologists were interested in the cultural role of plants and treated other scientific aspects superficially. In the early 20th century, botanists and anthropologists better collaborated and the collection of reliable, detailed cross-disciplinary data began.

Beginning in the 20th century, the field of ethnobotany experienced a shift from the raw compilation of data to a greater methodological and conceptual reorientation. This is also the beginning of academic ethnobotany. The so-called "father" of this discipline is Richard Evans Schultes, even though he did not actually coin the term "ethnobotany". Today the field of ethnobotany requires a variety of skills: botanical training for the identification and preservation of plant specimens; anthropological training to understand the cultural concepts around the perception of plants; linguistic training, at least enough to transcribe local terms and understand native morphology, syntax, and semantics.

Mark Plotkin, who studied at Harvard University, the Yale School of Forestry and Tufts University, has contributed a number of books on ethnobotany. He completed a handbook for the Tirio people of Suriname detailing their medicinal plants; Tales of a Shaman's Apprentice (1994); The Shaman's Apprentice, a children's book with Lynne Cherry (1998); and Medicine Quest: In Search of Nature's Healing Secrets (2000).

Plotkin was interviewed in 1998 by South American Explorer magazine, just after the release of Tales of a Shaman's Apprentice and the IMAX movie Amazonia. In the book, he stated that he saw wisdom in both traditional and Western forms of medicine:

No medical system has all the answers—no shaman that I've worked with has the equivalent of a polio vaccine and no dermatologist that I've been to could cure a fungal infection as effectively (and inexpensively) as some of my Amazonian mentors. It shouldn't be the doctor versus the witch doctor. It should be the best aspects of all medical systems (ayurvedic, herbalism, homeopathic, and so on) combined in a way which makes health care more effective and more affordable for all.

A great deal of information about the traditional uses of plants is still intact with tribal peoples. But the native healers are often reluctant to accurately share their knowledge to outsiders. Schultes actually apprenticed himself to an Amazonian shaman, which involves a long-term commitment and genuine relationship. In Wind in the Blood: Mayan Healing & Chinese Medicine by Garcia et al. the visiting acupuncturists were able to access levels of Mayan medicine that anthropologists could not because they had something to share in exchange. Cherokee medicine priest David Winston describes how his uncle would invent nonsense to satisfy visiting anthropologists.

Another scholar, James W. Herrick, who studied under ethnologist William N. Fenton, in his work Iroquois Medical Ethnobotany (1995) with Dean R. Snow (editor), professor of Anthropology at Penn State, explains that understanding herbal medicines in traditional Iroquois cultures is rooted in a strong and ancient cosmological belief system. Their work provides perceptions and conceptions of illness and imbalances which can manifest in physical forms from benign maladies to serious diseases. It also includes a large compilation of Herrick’s field work from numerous Iroquois authorities of over 450 names, uses, and preparations of plants for various ailments. Traditional Iroquois practitioners had (and have) a sophisticated perspective on the plant world that contrast strikingly with that of modern medical science.

Researcher Cassandra Quave at Emory University has used ethnobotany to address the problems that arise from antibiotic resistance. Quave notes that the advantage of medical ethnobotany over Western medicine rests in the difference in mechanism. For example, elmleaf blackberry extract focuses instead on the prevention of bacterial collaboration as opposed to directly exterminating them.

Issues

Many instances of gender bias have occurred in ethnobotany, creating the risk of drawing erroneous conclusions. Anthropologists would often consult with primarily men. In Las Pavas, a small farming community in Panama, anthropologists drew conclusions about the entire community's use of plant from their conversations and lessons with mostly men. They consulted with 40 families, but the women only participated rarely in interviews and never joined them in the field. Due to the division of labor, the knowledge of wild plants for food, medicine, and fibers, among others, was left out of the picture, resulting in a distorted view of which plants were actually important to them.

Ethnobotanists have also assumed that ownership of a resource means familiarity with that resource. In some societies women are excluded from owning land, while being the ones who work it. Inaccurate data can come from interviewing only the owners.

Other issues include ethical concerns regarding interactions with indigenous populations, and the International Society of Ethnobiology has created a code of ethics to guide researchers.

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