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Monday, July 25, 2022

Metamaterial cloaking

From Wikipedia, the free encyclopedia

Metamaterial cloaking is the usage of metamaterials in an invisibility cloak. This is accomplished by manipulating the paths traversed by light through a novel optical material. Metamaterials direct and control the propagation and transmission of specified parts of the light spectrum and demonstrate the potential to render an object seemingly invisible. Metamaterial cloaking, based on transformation optics, describes the process of shielding something from view by controlling electromagnetic radiation. Objects in the defined location are still present, but incident waves are guided around them without being affected by the object itself.

Electromagnetic metamaterials

Electromagnetic metamaterials respond to chosen parts of radiated light, also known as the electromagnetic spectrum, in a manner that is difficult or impossible to achieve with natural materials. In other words, these metamaterials can be further defined as artificially structured composite materials, which exhibit interaction with light usually not available in nature (electromagnetic interactions). At the same time, metamaterials have the potential to be engineered and constructed with desirable properties that fit a specific need. That need will be determined by the particular application.

The artificial structure for cloaking applications is a lattice design – a sequentially repeating network – of identical elements. Additionally, for microwave frequencies, these materials are analogous to crystals for optics. Also, a metamaterial is composed of a sequence of elements and spacings, which are much smaller than the selected wavelength of light. The selected wavelength could be radio frequency, microwave, or other radiations, now just beginning to reach into the visible frequencies. Macroscopic properties can be directly controlled by adjusting characteristics of the rudimentary elements, and their arrangement on, or throughout the material. Moreover, these metamaterials are a basis for building very small cloaking devices in anticipation of larger devices, adaptable to a broad spectrum of radiated light.

Hence, although light consists of an electric field and a magnetic field, ordinary optical materials, such as optical microscope lenses, have a strong reaction only to the electric field. The corresponding magnetic interaction is essentially nil. This results in only the most common optical effects, such as ordinary refraction with common diffraction limitations in lenses and imaging.

Since the beginning of optical sciences, centuries ago, the ability to control the light with materials has been limited to these common optical effects. Metamaterials, on the other hand, are capable of a very strong interaction, or coupling, with the magnetic component of light. Therefore, the range of response to radiated light is expanded beyond the ordinary optical limitations that are described by the sciences of physical optics and optical physics. In addition, as artificially constructed materials, both the magnetic and electric components of the radiated light can be controlled at will, in any desired fashion as it travels, or more accurately propagates, through the material. This is because a metamaterial's behavior is typically formed from individual components, and each component responds independently to a radiated spectrum of light. At this time, however, metamaterials are limited. Cloaking across a broad spectrum of frequencies has not been achieved, including the visible spectrum. Dissipation, absorption, and dispersion are also current drawbacks, but this field is still in its optimistic infancy.

Metamaterials and transformation optics

Left:The cross section of a PEC cylinder subject to a plane wave (only the electric field component of the wave is shown). The field is scattered. Right: a circular cloak, designed using transformation optics methods, is used to cloak the cylinder. In this case the field remains unchanged outside the cloak and the cylinder is invisible electromagnetically. Note the special distortion pattern of the field inside the cloak.

The field of transformation optics is founded on the effects produced by metamaterials.

Transformation optics has its beginnings in the conclusions of two research endeavors. They were published on May 25, 2006, in the same issue of Science, a peer reviewed journal. The two papers are tenable theories on bending or distorting light to electromagnetically conceal an object. Both papers notably map the initial configuration of the electromagnetic fields on to a Cartesian mesh. Twisting the Cartesian mesh, in essence, transforms the coordinates of the electromagnetic fields, which in turn conceal a given object. Hence, with these two papers, transformation optics is born.

Transformation optics subscribes to the capability of bending light, or electromagnetic waves and energy, in any preferred or desired fashion, for a desired application. Maxwell's equations do not vary even though coordinates transform. Instead it is the values of the chosen parameters of the materials which "transform", or alter, during a certain time period. So, transformation optics developed from the capability to choose the parameters for a given material. Hence, since Maxwell's equations retain the same form, it is the successive values of the parameters, permittivity and permeability, which change over time. Furthermore, permittivity and permeability are in a sense responses to the electric and magnetic fields of a radiated light source respectively, among other descriptions. The precise degree of electric and magnetic response can be controlled in a metamaterial, point by point. Since so much control can be maintained over the responses of the material, this leads to an enhanced and highly flexible gradient-index material. Conventionally predetermined refractive index of ordinary materials instead become independent spatial gradients in a metamaterial, which can be controlled at will. Therefore, transformation optics is a new method for creating novel and unique optical devices.

Science of cloaking devices

The purpose of a cloaking device is to hide something, so that a defined region of space is invisibly isolated from passing electromagnetic fields (or sound waves), as with Metamaterial cloaking.

Cloaking objects, or making them appear invisible with metamaterials, is roughly analogous to a magician's sleight of hand, or his tricks with mirrors. The object or subject doesn't really disappear; the vanishing is an illusion. With the same goal, researchers employ metamaterials to create directed blind spots by deflecting certain parts of the light spectrum (electromagnetic spectrum). It is the light spectrum, as the transmission medium, that determines what the human eye can see.

In other words, light is refracted or reflected determining the view, color, or illusion that is seen. The visible extent of light is seen in a chromatic spectrum such as the rainbow. However, visible light is only part of a broad spectrum, which extends beyond the sense of sight. For example, there are other parts of the light spectrum which are in common use today. The microwave spectrum is employed by radar, cell phones, and wireless Internet. The infrared spectrum is used for thermal imaging technologies, which can detect a warm body amidst a cooler night time environment, and infrared illumination is combined with specialized digital cameras for night vision. Astronomers employ the terahertz band for submillimeter observations to answer deep cosmological questions.

Furthermore, electromagnetic energy is light energy, but only a small part of it is visible light. This energy travels in waves. Shorter wavelengths, such as visible light and infrared, carry more energy per photon than longer waves, such as microwaves and radio waves. For the sciences, the light spectrum is known as the electromagnetic spectrum.

The properties of optics and light

Prisms, mirrors, and lenses have a long history of altering the diffracted visible light that surrounds all. However, the control exhibited by these ordinary materials is limited. Moreover, the one material which is common among these three types of directors of light is conventional glass. Hence, these familiar technologies are constrained by the fundamental, physical laws of optics. With metamaterials in general, and the cloaking technology in particular, it appears these barriers disintegrate with advancements in materials and technologies never before realized in the natural physical sciences. These unique materials became notable because electromagnetic radiation can be bent, reflected, or skewed in new ways. The radiated light could even be slowed or captured before transmission. In other words, new ways to focus and project light and other radiation are being developed. Furthermore, the expanded optical powers presented in the science of cloaking objects appear to be technologically beneficial across a wide spectrum of devices already in use. This means that every device with basic functions that rely on interaction with the radiated electromagnetic spectrum could technologically advance. With these beginning steps a whole new class of optics has been established.

Interest in the properties of optics and light

Interest in the properties of optics, and light, date back to almost 2000 years to Ptolemy (AD 85 – 165). In his work entitled Optics, he writes about the properties of light, including reflection, refraction, and color. He developed a simplified equation for refraction without trigonometric functions. About 800 years later, in AD 984, Ibn Sahl discovered a law of refraction mathematically equivalent to Snell's law. He was followed by the most notable Islamic scientist, Ibn Al-Haytham (c.965–1039), who is considered to be "one of the few most outstanding figures in optics in all times." He made significant advances in the science of physics in general, and optics in particular. He anticipated the universal laws of light articulated by seventeenth century scientists by hundreds of years.

In the seventeenth century both Willebrord Snellius and Descartes were credited with discovering the law of refraction. It was Snellius who noted that Ptolemy's equation for refraction was inexact. Consequently, these laws have been passed along, unchanged for about 400 years, like the laws of gravity.

Perfect cloak and theory

Electromagnetic radiation and matter have a symbiotic relationship. Radiation does not simply act on a material, nor is it simply acted upon by a given material. Radiation interacts with matter. Cloaking applications which employ metamaterials alter how objects interact with the electromagnetic spectrum. The guiding vision for the metamaterial cloak is a device that directs the flow of light smoothly around an object, like water flowing past a rock in a stream, without reflection, rendering the object invisible. In reality, the simple cloaking devices of the present are imperfect, and have limitations. One challenge up to the present date has been the inability of metamaterials, and cloaking devices, to interact at frequencies, or wavelengths, within the visible light spectrum.

Challenges presented by the first cloaking device

The principle of cloaking, with a cloaking device, was first proved (demonstrated) at frequencies in the microwave radiation band on October 19, 2006. This demonstration used a small cloaking device. Its height was less than one half inch (< 13 mm) and its diameter five inches (125 mm), and it successfully diverted microwaves around itself. The object to be hidden from view, a small cylinder, was placed in the center of the device. The invisibility cloak deflected microwave beams so they flowed around the cylinder inside with only minor distortion, making it appear almost as if nothing were there at all.

Such a device typically involves surrounding the object to be cloaked with a shell which affects the passage of light near it. There was reduced reflection of electromagnetic waves (microwaves), from the object. Unlike a homogeneous natural material with its material properties the same everywhere, the cloak's material properties vary from point to point, with each point designed for specific electromagnetic interactions (inhomogeneity), and are different in different directions (anisotropy). This accomplishes a gradient in the material properties. The associated report was published in the journal Science.

Although a successful demonstration, three notable limitations can be shown. First, since its effectiveness was only in the microwave spectrum the small object is somewhat invisible only at microwave frequencies. This means invisibility had not been achieved for the human eye, which sees only within the visible spectrum. This is because the wavelengths of the visible spectrum are tangibly shorter than microwaves. However, this was considered the first step toward a cloaking device for visible light, although more advanced nanotechnology-related techniques would be needed due to light's short wavelengths. Second, only small objects can be made to appear as the surrounding air. In the case of the 2006 proof of cloaking demonstration, the hidden from view object, a copper cylinder, would have to be less than five inches in diameter, and less than one half inch tall. Third, cloaking can only occur over a narrow frequency band, for any given demonstration. This means that a broad band cloak, which works across the electromagnetic spectrum, from radio frequencies to microwave to the visible spectrum, and to x-ray, is not available at this time. This is due to the dispersive nature of present-day metamaterials. The coordinate transformation (transformation optics) requires extraordinary material parameters that are only approachable through the use of resonant elements, which are inherently narrow band, and dispersive at resonance.

Usage of metamaterials

At the very beginning of the new millennium, metamaterials were established as an extraordinary new medium, which expanded control capabilities over matter. Hence, metamaterials are applied to cloaking applications for a few reasons. First, the parameter known as material response has broader range. Second, the material response can be controlled at will.

Third, optical components, such as lenses, respond within a certain defined range to light. As stated earlier – the range of response has been known, and studied, going back to Ptolemy – eighteen hundred years ago. The range of response could not be effectively exceeded, because natural materials proved incapable of doing so. In scientific studies and research, one way to communicate the range of response is the refractive index of a given optical material. Every natural material so far only allows for a positive refractive index. Metamaterials, on the other hand, are an innovation that are able to achieve negative refractive index, zero refractive index, and fractional values in between zero and one. Hence, metamaterials extend the material response, among other capabilities. However, negative refraction is not the effect that creates invisibility-cloaking. It is more accurate to say that gradations of refractive index, when combined, create invisibility-cloaking. Fourth, and finally, metamaterials demonstrate the capability to deliver chosen responses at will.

Device

Before actually building the device, theoretical studies were conducted. The following is one of two studies accepted simultaneously by a scientific journal, as well being distinguished as one of the first published theoretical works for an invisibility cloak.

Controlling electromagnetic fields

Orthogonal coordinates — Cartesian plane as it transforms from rectangular to curvilinear coordinates

The exploitation of "light", the electromagnetic spectrum, is accomplished with common objects and materials which control and direct the electromagnetic fields. For example, a glass lens in a camera is used to produce an image, a metal cage may be used to screen sensitive equipment, and radio antennas are designed to transmit and receive daily FM broadcasts. Homogeneous materials, which manipulate or modulate electromagnetic radiation, such as glass lenses, are limited in the upper limit of refinements to correct for aberrations. Combinations of inhomogeneous lens materials are able to employ gradient refractive indices, but the ranges tend to be limited.

Metamaterials were introduced about a decade ago, and these expand control of parts of the electromagnetic spectrum; from microwave, to terahertz, to infrared. Theoretically, metamaterials, as a transmission medium, will eventually expand control and direction of electromagnetic fields into the visible spectrum. Hence, a design strategy was introduced in 2006, to show that a metamaterial can be engineered with arbitrarily assigned positive or negative values of permittivity and permeability, which can also be independently varied at will. Then direct control of electromagnetic fields becomes possible, which is relevant to novel and unusual lens design, as well as a component of the scientific theory for cloaking of objects from electromagnetic detection.

Each component responds independently to a radiated electromagnetic wave as it travels through the material, resulting in electromagnetic inhomogeneity for each component. Each component has its own response to the external electric and magnetic fields of the radiated source. Since these components are smaller than the radiated wavelength it is understood that a macroscopic view includes an effective value for both permittivity and permeability. These materials obey the laws of physics, but behave differently from normal materials. Metamaterials are artificial materials engineered to provide properties which "may not be readily available in nature". These materials usually gain their properties from structure rather than composition, using the inclusion of small inhomogeneities to enact effective macroscopic behavior.

The structural units of metamaterials can be tailored in shape and size. Their composition, and their form or structure, can be finely adjusted. Inclusions can be designed, and then placed at desired locations in order to vary the function of a given material. As the lattice is constant, the cells are smaller than the radiated light.

The design strategy has at its core inhomogeneous composite metamaterials which direct, at will, conserved quantities of electromagnetism. These quantities are specifically, the electric displacement field D, the magnetic field intensity B, and the Poynting vector S. Theoretically, when regarding the conserved quantities, or fields, the metamaterial exhibits a twofold capability. First, the fields can be concentrated in a given direction. Second, they can be made to avoid or surround objects, returning without perturbation to their original path. These results are consistent with Maxwell's equations and are more than only ray approximation found in geometrical optics. Accordingly, in principle, these effects can encompass all forms of electromagnetic radiation phenomena on all length scales.

The hypothesized design strategy begins with intentionally choosing a configuration of an arbitrary number of embedded sources. These sources become localized responses of permittivity, ε, and magnetic permeability, μ. The sources are embedded in an arbitrarily selected transmission medium with dielectric and magnetic characteristics. As an electromagnetic system the medium can then be schematically represented as a grid.

The first requirement might be to move a uniform electric field through space, but in a definite direction, which avoids an object or obstacle. Next remove and embed the system in an elastic medium that can be warped, twisted, pulled or stretched as desired. The initial condition of the fields is recorded on a Cartesian mesh. As the elastic medium is distorted in one, or combination, of the described possibilities, the same pulling and stretching process is recorded by the Cartesian mesh. The same set of contortions can now be recorded, occurring as coordinate transformation:

a (x,y,z), b (x,y,z), c (x,y,z), d (x,y,z) ....

Hence, the permittivity, ε, and permeability, µ, is proportionally calibrated by a common factor. This implies that less precisely, the same occurs with the refractive index. Renormalized values of permittivity and permeability are applied in the new coordinate system. For the renormalization equations see ref. #.

Application to cloaking devices

Given the above parameters of operation, the system, a metamaterial, can now be shown to be able to conceal an object of arbitrary size. Its function is to manipulate incoming rays, which are about to strike the object. These incoming rays are instead electromagnetically steered around the object by the metamaterial, which then returns them to their original trajectory. As part of the design it can be assumed that no radiation leaves the concealed volume of space, and no radiation can enter the space. As illustrated by the function of the metamaterial, any radiation attempting to penetrate is steered around the space or the object within the space, returning to the initial direction. It appears to any observer that the concealed volume of space is empty, even with an object present there. An arbitrary object may be hidden because it remains untouched by external radiation.

A sphere with radius R1 is chosen as the object to be hidden. The cloaking region is to be contained within the annulus R1 < r < R2. A simple transformation that achieves the desired result can be found by taking all fields in the region r < R2 and compressing them into the region R1 < r < R2. The coordinate transformations do not alter Maxwell's equations. Only the values of ε′ and µ′ change over time.

Cloaking hurdles

There are issues to be dealt with to achieve invisibility cloaking. One issue, related to ray tracing, is the anisotropic effects of the material on the electromagnetic rays entering the "system". Parallel bundles of rays, (see above image), headed directly for the center are abruptly curved and, along with neighboring rays, are forced into tighter and tighter arcs. This is due to rapid changes in the now shifting and transforming permittivity ε′ and permeability µ′. The second issue is that, while it has been discovered that the selected metamaterials are capable of working within the parameters of the anisotropic effects and the continual shifting of ε′ and µ′, the values for ε′ and µ′ cannot be very large or very small. The third issue is that the selected metamaterials are currently unable to achieve broad, frequency spectrum capabilities. This is because the rays must curve around the "concealed" sphere, and therefore have longer trajectories than traversing free space, or air. However, the rays must arrive around the other side of the sphere in phase with the beginning radiated light. If this is happening then the phase velocity exceeds the velocity of light in a vacuum, which is the speed limit of the universe. (Note, this does not violate the laws of physics). And, with a required absence of frequency dispersion, the group velocity will be identical with phase velocity. In the context of this experiment, group velocity can never exceed the velocity of light, hence the analytical parameters are effective for only one frequency.

Optical conformal mapping and ray tracing in transformation media

The goal then is to create no discernible difference between a concealed volume of space and the propagation of electromagnetic waves through empty space. It would appear that achieving a perfectly concealed (100%) hole, where an object could be placed and hidden from view, is not probable. The problem is the following: in order to carry images, light propagates in a continuous range of directions. The scattering data of electromagnetic waves, after bouncing off an object or hole, is unique compared to light propagating through empty space, and is therefore easily perceived. Light propagating through empty space is consistent only with empty space. This includes microwave frequencies.

Although mathematical reasoning shows that perfect concealment is not probable because of the wave nature of light, this problem does not apply to electromagnetic rays, i.e., the domain of geometrical optics. Imperfections can be made arbitrarily, and exponentially small for objects that are much larger than the wavelength of light.

Mathematically, this implies n < 1, because the rays follow the shortest path and hence in theory create a perfect concealment. In practice, a certain amount of acceptable visibility occurs, as noted above. The range of the refractive index of the dielectric (optical material) needs to be across a wide spectrum to achieve concealment, with the illusion created by wave propagation across empty space. These places where n < 1 would be the shortest path for the ray around the object without phase distortion. Artificial propagation of empty space could be reached in the microwave-to-terahertz range. In stealth technology, impedance matching could result in absorption of beamed electromagnetic waves rather than reflection, hence, evasion of detection by radar. These general principles can also be applied to sound waves, where the index n describes the ratio of the local phase velocity of the wave to the bulk value. Hence, it would be useful to protect a space from any sound sourced detection. This also implies protection from sonar. Furthermore, these general principles are applicable in diverse fields such as electrostatics, fluid mechanics, classical mechanics, and quantum chaos.

Mathematically, it can be shown that the wave propagation is indistinguishable from empty space where light rays propagate along straight lines. The medium performs an optical conformal mapping to empty space.

Microwave frequencies

The next step, then, is to actually conceal an object by controlling electromagnetic fields. Now, the demonstrated and theoretical ability for controlled electromagnetic fields has opened a new field, transformation optics. This nomenclature is derived from coordinate transformations used to create variable pathways for the propagation of light through a material. This demonstration is based on previous theoretical prescriptions, along with the accomplishment of the prism experiment. One possible application of transformation optics and materials is electromagnetic cloaking for the purpose of rendering a volume or object undetectable to incident radiation, including radiated probing.

This demonstration, for the first time, of actually concealing an object with electromagnetic fields, uses the method of purposely designed spatial variation. This is an effect of embedding purposely designed electromagnetic sources in the metamaterial.

As discussed earlier, the fields produced by the metamaterial are compressed into a shell (coordinate transformations) surrounding the now concealed volume. Earlier this was supported theory; this experiment demonstrated the effect actually occurs. Maxwell's equations are scalar when applying transformational coordinates, only the permittivity tensor and permeability tensor are affected, which then become spatially variant, and directionally dependent along different axes. The researchers state:

By implementing these complex material properties, the concealed volume plus the cloak appear to have the properties of free space when viewed externally. The cloak thus neither scatters waves nor imparts a shadow in the either of which would enable the cloak to be detected. Other approaches to invisibility either rely on the reduction of backscatter or make use of a resonance in which the properties of the cloaked object and the must be carefully matched. ...Advances in the development of [negative index metamaterials], especially with respect to gradient index lenses, have made the physical realization of the specified complex material properties feasible. We implemented a two-dimensional (2D) cloak because its fabrication and measurement requirements were simpler than those of a 3D cloak.

Before the actual demonstration, the experimental limits of the transformational fields were computationally determined, in addition to simulations, as both were used to determine the effectiveness of the cloak.

A month prior to this demonstration, the results of an experiment to spatially map the internal and external electromagnetic fields of negative refractive metamaterial was published in September 2006. This was innovative because prior to this the microwave fields were measured only externally. In this September experiment the permittivity and permeability of the microstructures (instead of external macrostructure) of the metamaterial samples were measured, as well as the scattering by the two-dimensional negative index metamaterials. This gave an average effective refractive index, which results in assuming homogeneous metamaterial.

Employing this technique for this experiment, spatial mapping of phases and amplitudes of the microwave radiations interacting with metamaterial samples was conducted. The performance of the cloak was confirmed by comparing the measured field maps to simulations.

For this demonstration, the concealed object was a conducting cylinder at the inner radius of the cloak. As the largest possible object designed for this volume of space, it has the most substantial scattering properties. The conducting cylinder was effectively concealed in two dimensions.

Infrared frequencies

The definition optical frequency, in metamaterials literature, ranges from far infrared, to near infrared, through the visible spectrum, and includes at least a portion of ultra-violet. To date when literature refers optical frequencies these are almost always frequencies in the infrared, which is below the visible spectrum. In 2009 a group of researchers announced cloaking at optical frequencies. In this case the cloaking frequency was centered at 1500 nm or 1.5 micrometers – the infrared.

Sonic frequencies

A laboratory metamaterial device, applicable to ultra-sound waves was demonstrated in January 2011. It can be applied to sound wavelengths corresponding to frequencies from 40 to 80 kHz.

The metamaterial acoustic cloak is designed to hide objects submerged in water. The metamaterial cloaking mechanism bends and twists sound waves by intentional design.

The cloaking mechanism consists of 16 concentric rings in a cylindrical configuration. Each ring has acoustic circuits. It is intentionally designed to guide sound waves in two dimensions.

Each ring has a different index of refraction. This causes sound waves to vary their speed from ring to ring. "The sound waves propagate around the outer ring, guided by the channels in the circuits, which bend the waves to wrap them around the outer layers of the cloak". It forms an array of cavities that slow the speed of the propagating sound waves. An experimental cylinder was submerged and then disappeared from sonar. Other objects of various shape and density were also hidden from the sonar. The acoustic cloak demonstrated effectiveness for frequencies of 40 kHz to 80 kHz.

In 2014 researchers created a 3D acoustic cloak from stacked plastic sheets dotted with repeating patterns of holes. The pyramidal geometry of the stack and the hole placement provide the effect.

Invisibility in diffusive light scattering media

In 2014, scientists demonstrated good cloaking performance in murky water, demonstrating that an object shrouded in fog can disappear completely when appropriately coated with metamaterial. This is due to the random scattering of light, such as that which occurs in clouds, fog, milk, frosted glass, etc., combined with the properties of the metatmaterial coating. When light is diffused, a thin coat of metamaterial around an object can make it essentially invisible under a range of lighting conditions.

Cloaking attempts

Broadband ground-plane cloak

If a transformation to quasi-orthogonal coordinates is applied to Maxwell's equations in order to conceal a perturbation on a flat conducting plane rather than a singular point, as in the first demonstration of a transformation optics-based cloak, then an object can be hidden underneath the perturbation. This is sometimes referred to as a "carpet" cloak.

As noted above, the original cloak demonstrated utilized resonant metamaterial elements to meet the effective material constraints. Utilizing a quasi-conformal transformation in this case, rather than the non-conformal original transformation, changed the required material properties. Unlike the original (singular expansion) cloak, the "carpet" cloak required less extreme material values. The quasi-conformal carpet cloak required anisotropic, inhomogeneous materials which only varied in permittivity. Moreover, the permittivity was always positive. This allowed the use of non-resonant metamaterial elements to create the cloak, significantly increasing the bandwidth.

An automated process, guided by a set of algorithms, was used to construct a metamaterial consisting of thousands of elements, each with its own geometry. Developing the algorithm allowed the manufacturing process to be automated, which resulted in fabrication of the metamaterial in nine days. The previous device used in 2006 was rudimentary in comparison, and the manufacturing process required four months in order to create the device. These differences are largely due to the different form of transformation: the original 2006 cloak transformed a singular point, while the ground-plane version transforms a plane, and the transformation in the carpet cloak was quasi-conformal, rather than non-conformal.

Other theories of cloaking

Other theories of cloaking discuss various science and research based theories for producing an electromagnetic cloak of invisibility. Theories presented employ transformation optics, event cloaking, dipolar scattering cancellation, tunneling light transmittance, sensors and active sources, and acoustic cloaking.

Institutional research

The research in the field of metamaterials has diffused out into the American government science research departments, including the US Naval Air Systems Command, US Air Force, and US Army. Many scientific institutions are involved including:

Funding for research into this technology is provided by the following American agencies:

Through this research, it has been realized that developing a method for controlling electromagnetic fields can be applied to escape detection by radiated probing, or sonar technology, and to improve communications in the microwave range; that this method is relevant to superlens design and to the cloaking of objects within and from electromagnetic fields.

In the news

On October 20, 2006, the day after Duke University achieved enveloping and "disappearing" an object in the microwave range, the story was reported by Associated Press. Media outlets covering the story included USA Today, MSNBC's Countdown With Keith Olbermann: Sight Unseen, The New York Times with Cloaking Copper, Scientists Take Step Toward Invisibility, (London) The Times with Don't Look Now—Visible Gains in the Quest for Invisibility, Christian Science Monitor with Disappear Into Thin Air? Scientists Take Step Toward Invisibility, Australian Broadcasting, Reuters with Invisibility Cloak a Step Closer, and the (Raleigh) News & Observer with 'Invisibility Cloak a Step Closer.

On November 6, 2006, the Duke University research and development team was selected as part of the Scientific American best 50 articles of 2006.

In the month of November 2009, "research into designing and building unique 'metamaterials' has received a £4.9 million funding boost. Metamaterials can be used for invisibility 'cloaking' devices, sensitive security sensors that can detect tiny quantities of dangerous substances, and flat lenses that can be used to image tiny objects much smaller than the wavelength of light."

In November 2010, scientists at the University of St Andrews in Scotland reported the creation of a flexible cloaking material they call "Metaflex", which may bring industrial applications significantly closer.

In 2014, the world 's first 3D acoustic device was built by Duke engineers.

Photonic crystal

From Wikipedia, the free encyclopedia
 
The opal in this bracelet contains a natural periodic microstructure responsible for its iridescent color. It is essentially a natural photonic crystal.
 
Wings of some butterflies contain photonic crystals.

A photonic crystal is an optical nanostructure in which the refractive index changes periodically. This affects the propagation of light in the same way that the structure of natural crystals gives rise to X-ray diffraction and that the atomic lattices (crystal structure) of semiconductors affect their conductivity of electrons. Photonic crystals occur in nature in the form of structural coloration and animal reflectors, and, as artificially produced, promise to be useful in a range of applications.

Photonic crystals can be fabricated for one, two, or three dimensions. One-dimensional photonic crystals can be made of thin film layers deposited on each other. Two-dimensional ones can be made by photolithography, or by drilling holes in a suitable substrate. Fabrication methods for three-dimensional ones include drilling under different angles, stacking multiple 2-D layers on top of each other, direct laser writing, or, for example, instigating self-assembly of spheres in a matrix and dissolving the spheres.

Photonic crystals can, in principle, find uses wherever light must be manipulated. For example, dielectric mirrors are one-dimensional photonic crystals which can produce ultra-high reflectivity mirrors at a specified wavelength. Two-dimensional photonic crystals called photonic-crystal fibers are used for fiber-optic communication, among other applications. Three-dimensional crystals may one day be used in optical computers, and could lead to more efficient photovoltaic cells.

Although the energy of light (and all electromagnetic radiation) is quantized in units called photons, the analysis of photonic crystals requires only classical physics. "Photonic" in the name is a reference to photonics, a modern designation for the study of light (optics) and optical engineering. Indeed, the first research into what we now call photonic crystals may have been as early as 1887 when the English physicist Lord Rayleigh experimented with periodic multi-layer dielectric stacks, showing they can effect a photonic band-gap in one dimension. Research interest grew with work in 1987 by Eli Yablonovitch and Sajeev John on periodic optical structures with more than one dimension—now called photonic crystals.

Introduction

0:41
Diffraction from a periodic structure as a function of incident wavelength. For some wavelength ranges, the wave is unable to penetrate the structure.

Photonic crystals are composed of periodic dielectric, metallo-dielectric—or even superconductor microstructures or nanostructures that affect electromagnetic wave propagation in the same way that the periodic potential in a semiconductor crystal affects the propagation of electrons, determining allowed and forbidden electronic energy bands. Photonic crystals contain regularly repeating regions of high and low refractive index. Light waves may propagate through this structure or propagation may be disallowed, depending on their wavelength. Wavelengths that may propagate in a given direction are called modes, and the ranges of wavelengths which propagate are called bands. Disallowed bands of wavelengths are called photonic band gaps. This gives rise to distinct optical phenomena, such as inhibition of spontaneous emission, high-reflecting omni-directional mirrors, and low-loss-waveguiding. The bandgap of photonic crystals can be understood as the destructive interference of multiple reflections of light propagating in the crystal at each interface between layers of high- and low- refractive index regions, akin to the bandgaps of electrons in solids.

The periodicity of the photonic crystal structure must be around or greater than half the wavelength (in the medium) of the light waves in order for interference effects to be exhibited. Visible light ranges in wavelength between about 400 nm (violet) to about 700 nm (red) and the resulting wavelength inside a material requires dividing that by the average index of refraction. The repeating regions of high and low dielectric constant must, therefore, be fabricated at this scale. In one dimension, this is routinely accomplished using the techniques of thin-film deposition.

History

Photonic crystals have been studied in one form or another since 1887, but no one used the term photonic crystal until over 100 years later—after Eli Yablonovitch and Sajeev John published two milestone papers on photonic crystals in 1987. The early history is well-documented in the form of a story when it was identified as one of the landmark developments in physics by the American Physical Society.

Before 1987, one-dimensional photonic crystals in the form of periodic multi-layer dielectric stacks (such as the Bragg mirror) were studied extensively. Lord Rayleigh started their study in 1887, by showing that such systems have a one-dimensional photonic band-gap, a spectral range of large reflectivity, known as a stop-band. Today, such structures are used in a diverse range of applications—from reflective coatings to enhancing LED efficiency to highly reflective mirrors in certain laser cavities (see, for example, VCSEL). The pass-bands and stop-bands in photonic crystals were first reduced to practice by Melvin M. Weiner who called those crystals "discrete phase-ordered media." Melvin M. Weiner achieved those results by extending Darwin's dynamical theory for x-ray Bragg diffraction to arbitrary wavelengths, angles of incidence, and cases where the incident wavefront at a lattice plane is scattered appreciably in the forward-scattered direction. A detailed theoretical study of one-dimensional optical structures was performed by Vladimir P. Bykov, who was the first to investigate the effect of a photonic band-gap on the spontaneous emission from atoms and molecules embedded within the photonic structure. Bykov also speculated as to what could happen if two- or three-dimensional periodic optical structures were used. The concept of three-dimensional photonic crystals was then discussed by Ohtaka in 1979, who also developed a formalism for the calculation of the photonic band structure. However, these ideas did not take off until after the publication of two milestone papers in 1987 by Yablonovitch and John. Both these papers concerned high-dimensional periodic optical structures, i.e., photonic crystals. Yablonovitch's main goal was to engineer photonic density of states to control the spontaneous emission of materials embedded in the photonic crystal. John's idea was to use photonic crystals to affect localisation and control of light.

After 1987, the number of research papers concerning photonic crystals began to grow exponentially. However, due to the difficulty of fabricating these structures at optical scales (see Fabrication challenges), early studies were either theoretical or in the microwave regime, where photonic crystals can be built on the more accessible centimetre scale. (This fact is due to a property of the electromagnetic fields known as scale invariance. In essence, electromagnetic fields, as the solutions to Maxwell's equations, have no natural length scale—so solutions for centimetre scale structure at microwave frequencies are the same as for nanometre scale structures at optical frequencies.)

By 1991, Yablonovitch had demonstrated the first three-dimensional photonic band-gap in the microwave regime. The structure that Yablonovitch was able to produce involved drilling an array of holes in a transparent material, where the holes of each layer form an inverse diamond structure – today it is known as Yablonovite.

In 1996, Thomas Krauss demonstrated a two-dimensional photonic crystal at optical wavelengths. This opened the way to fabricate photonic crystals in semiconductor materials by borrowing methods from the semiconductor industry.

Today, such techniques use photonic crystal slabs, which are two dimensional photonic crystals "etched" into slabs of semiconductor. Total internal reflection confines light to the slab, and allows photonic crystal effects, such as engineering photonic dispersion in the slab. Researchers around the world are looking for ways to use photonic crystal slabs in integrated computer chips, to improve optical processing of communications—both on-chip and between chips.

Autocloning fabrication technique, proposed for infrared and visible range photonic crystals by Sato et al. in 2002, utilizes electron-beam lithography and dry etching: lithographically-formed layers of periodic grooves are stacked by regulated sputter deposition and etching, resulting in "stationary corrugations" and periodicity. Titanium dioxide/silica and tantalum pentoxide/silica devices were produced, exploiting their dispersion characteristics and suitability to sputter deposition.

Such techniques have yet to mature into commercial applications, but two-dimensional photonic crystals are commercially used in photonic crystal fibres (otherwise known as holey fibres, because of the air holes that run through them). Photonic crystal fibres were first developed by Philip Russell in 1998, and can be designed to possess enhanced properties over (normal) optical fibres.

Study has proceeded more slowly in three-dimensional than in two-dimensional photonic crystals. This is because of more difficult fabrication. Three-dimensional photonic crystal fabrication had no inheritable semiconductor industry techniques to draw on. Attempts have been made, however, to adapt some of the same techniques, and quite advanced examples have been demonstrated, for example in the construction of "woodpile" structures constructed on a planar layer-by-layer basis. Another strand of research has tried to construct three-dimensional photonic structures from self-assembly—essentially letting a mixture of dielectric nano-spheres settle from solution into three-dimensionally periodic structures that have photonic band-gaps. Vasily Astratov's group from the Ioffe Institute realized in 1995 that natural and synthetic opals are photonic crystals with an incomplete bandgap. The first demonstration of an "inverse opal" structure with a complete photonic bandgap came in 2000, from researchers at the University of Toronto, Canada, and Institute of Materials Science of Madrid (ICMM-CSIC), Spain. The ever-expanding field of natural photonics, bioinspiration and biomimetics—the study of natural structures to better understand and use them in design—is also helping researchers in photonic crystals. For example, in 2006 a naturally occurring photonic crystal was discovered in the scales of a Brazilian beetle. Analogously, in 2012 a diamond crystal structure was found in a weevil and a gyroid-type architecture in a butterfly. More recently, gyroid photonic crystals have been found in the feather barbs of blue-winged leafbirds and are responsible for the bird's shimmery blue coloration.

Construction strategies

The fabrication method depends on the number of dimensions that the photonic bandgap must exist in.

One-dimensional photonic crystals

To produce a one-dimensional photonic crystal, thin film layers of different dielectric constant may be periodically deposited on a surface which leads to a band gap in a particular propagation direction (such as normal to the surface). A Bragg grating is an example of this type of photonic crystal. One-dimensional photonic crystals can include layers of non-linear optical materials in which the non-linear behaviour is accentuated due to field enhancement at wavelengths near a so-called degenerate band edge. This field enhancement (in terms of intensity) can reach where N is the total number of layers. However by using layers which include an optically anisotropic material, it has been shown that the field enhancement can reach , which, in conjunction with non-linear optics, has potential applications such as in the development of an all-optical switch.

A one-dimensional photonic crystal can be implemented using repeated alternating layers of a metamaterial and vacuum. If the metamaterial is such that the relative permittivity and permeability follow the same wavelength dependence, then the photonic crystal behaves identically for TE and TM modes, that is, for both s and p polarizations of light incident at an angle.

Recently, researchers fabricated a graphene-based Bragg grating (one-dimensional photonic crystal) and demonstrated that it supports excitation of surface electromagnetic waves in the periodic structure by using 633 nm He-Ne laser as the light source. Besides, a novel type of one-dimensional graphene-dielectric photonic crystal has also been proposed. This structure can act as a far-IR filter and can support low-loss surface plasmons for waveguide and sensing applications. 1D photonic crystals doped with bio-active metals (i.e. silver) have been also proposed as sensing devices for bacterial contaminants. Similar planar 1D photonic crystals made of polymers have been used to detect volatile organic compounds vapors in atmosphere. In addition to solid-phase photonic crystals, some liquid crystals with defined ordering can demonstrate photonic color. For example, studies have shown several liquid crystals with short- or long-range one-dimensional positional ordering can form photonic structures.

Two-dimensional photonic crystals

In two dimensions, holes may be drilled in a substrate that is transparent to the wavelength of radiation that the bandgap is designed to block. Triangular and square lattices of holes have been successfully employed.

The Holey fiber or photonic crystal fiber can be made by taking cylindrical rods of glass in hexagonal lattice, and then heating and stretching them, the triangle-like airgaps between the glass rods become the holes that confine the modes.

Three-dimensional photonic crystals

There are several structure types that have been constructed:

  • Spheres in a diamond lattice
  • Yablonovite
  • The woodpile structure – "rods" are repeatedly etched with beam lithography, filled in, and covered with a layer of new material. As the process repeats, the channels etched in each layer are perpendicular to the layer below, and parallel to and out of phase with the channels two layers below. The process repeats until the structure is of the desired height. The fill-in material is then dissolved using an agent that dissolves the fill-in material but not the deposition material. It is generally hard to introduce defects into this structure.
  • Inverse opals or Inverse Colloidal Crystals-Spheres (such as polystyrene or silicon dioxide) can be allowed to deposit into a cubic close packed lattice suspended in a solvent. Then a hardener is introduced that makes a transparent solid out of the volume occupied by the solvent. The spheres are then dissolved with an acid such as Hydrochloric acid. The colloids can be either spherical or nonspherical. contains in excess of 750,000 polymer nanorods. Light focused on this beam splitter penetrates or is reflected, depending on polarization.
A photonic crystal fiber
A photonic crystal fiber. SEM images of US NRL-produced fiber. (left) The diameter of the solid core at the center of the fiber is 5 µm, while (right) the diameter of the holes is 4 µm. Source: http://www.nrl.navy.mil/techtransfer/fs.php?fs_id=97
 
An SEM image of a self-assembled PMMA photonic crystal in two dimensions

Photonic crystal cavities

Not only band gap, photonic crystals may have another effect if we partially remove the symmetry through the creation a nanosize cavity. This defect allows you to guide or to trap the light with the same function as nanophotonic resonator and it is characterized by the strong dielectric modulation in the photonic crystals. For the waveguide, the propagation of light depends on the in-plane control provided by the photonic band gap and to the long confinement of light induced by dielectric mismatch. For the light trap, the light is strongly confined in the cavity resulting further interactions with the materials. First, if we put a pulse of light inside the cavity, it will be delayed by nano- or picoseconds and this is proportional to the quality factor of the cavity. Finally, if we put an emitter inside the cavity, the emission light also can be enhanced significantly and or even the resonant coupling can go through Rabi oscillation. This is related with cavity quantum electrodynamics and the interactions are defined by the weak and strong coupling of the emitter and the cavity. The first studies for the cavity in one-dimensional photonic slabs are usually in grating or distributed feedback structures. For two-dimensional photonic crystal cavities, they are useful to make efficient photonic devices in telecommunication applications as they can provide very high quality factor up to millions with smaller-than-wavelength mode volume. For three-dimensional photonic crystal cavities, several methods have been developed including lithographic layer-by-layer approach, surface ion beam lithography, and micromanipulation technique. All those mentioned photonic crystal cavities that tightly confine light offer very useful functionality for integrated photonic circuits, but it is challenging to produce them in a manner that allows them to be easily relocated. There is no full control with the cavity creation, the cavity location, and the emitter position relative to the maximum field of the cavity while the studies to solve those problems are still ongoing. Movable cavity of nanowire in photonic crystals is one of solutions to tailor this light matter interaction.

Fabrication challenges

Higher-dimensional photonic crystal fabrication faces two major challenges:

  • Making them with enough precision to prevent scattering losses blurring the crystal properties
  • Designing processes that can robustly mass-produce the crystals

One promising fabrication method for two-dimensionally periodic photonic crystals is a photonic-crystal fiber, such as a holey fiber. Using fiber draw techniques developed for communications fiber it meets these two requirements, and photonic crystal fibres are commercially available. Another promising method for developing two-dimensional photonic crystals is the so-called photonic crystal slab. These structures consist of a slab of material—such as silicon—that can be patterned using techniques from the semiconductor industry. Such chips offer the potential to combine photonic processing with electronic processing on a single chip.

For three dimensional photonic crystals, various techniques have been used—including photolithography and etching techniques similar to those used for integrated circuits. Some of these techniques are already commercially available. To avoid the complex machinery of nanotechnological methods, some alternate approaches involve growing photonic crystals from colloidal crystals as self-assembled structures.

Mass-scale 3D photonic crystal films and fibres can now be produced using a shear-assembly technique that stacks 200–300 nm colloidal polymer spheres into perfect films of fcc lattice. Because the particles have a softer transparent rubber coating, the films can be stretched and molded, tuning the photonic bandgaps and producing striking structural color effects.

Computing photonic band structure

The photonic band gap (PBG) is essentially the gap between the air-line and the dielectric-line in the dispersion relation of the PBG system. To design photonic crystal systems, it is essential to engineer the location and size of the bandgap by computational modeling using any of the following methods:

0:03
A video simulation of scattering forces and fields in a photonic crystal structure

Essentially, these methods solve for the frequencies (normal modes) of the photonic crystal for each value of the propagation direction given by the wave vector, or vice versa. The various lines in the band structure, correspond to the different cases of n, the band index. For an introduction to photonic band structure, see K. Sakoda's  and Joannopoulos  books.

Band structure of a 1D photonic crystal, DBR air-core calculated using plane wave expansion technique with 101 planewaves, for d/a=0.8, and dielectric contrast of 12.250.

The plane wave expansion method can be used to calculate the band structure using an eigen formulation of the Maxwell's equations, and thus solving for the eigen frequencies for each of the propagation directions, of the wave vectors. It directly solves for the dispersion diagram. Electric field strength values can also be calculated over the spatial domain of the problem using the eigen vectors of the same problem. For the picture shown to the right, corresponds to the band-structure of a 1D distributed Bragg reflector (DBR) with air-core interleaved with a dielectric material of relative permittivity 12.25, and a lattice period to air-core thickness ratio (d/a) of 0.8, is solved using 101 planewaves over the first irreducible Brillouin zone.

To speed calculation of the frequency band structure, the Reduced Bloch Mode Expansion (RBME) method can be used. The RBME method applies "on top" of any of the primary expansion methods mentioned above. For large unit cell models, the RBME method can reduce time for computing the band structure by up to two orders of magnitude.

Applications

Photonic crystals are attractive optical materials for controlling and manipulating light flow. One dimensional photonic crystals are already in widespread use, in the form of thin-film optics, with applications from low and high reflection coatings on lenses and mirrors to colour changing paints and inks. Higher-dimensional photonic crystals are of great interest for both fundamental and applied research, and the two dimensional ones are beginning to find commercial applications.

The first commercial products involving two-dimensionally periodic photonic crystals are already available in the form of photonic-crystal fibers, which use a microscale structure to confine light with radically different characteristics compared to conventional optical fiber for applications in nonlinear devices and guiding exotic wavelengths. The three-dimensional counterparts are still far from commercialization but may offer additional features such as optical nonlinearity required for the operation of optical transistors used in optical computers, when some technological aspects such as manufacturability and principal difficulties such as disorder are under control.

In addition to the foregoing, photonic crystals have been proposed as platforms for the development of solar cells and optical sensors, including chemical sensors and biosensors.

Sunday, July 24, 2022

Frailty syndrome

From Wikipedia, the free encyclopedia
 
Frailty syndrome
A woman supporting herself with a walking frame.jpg
A woman supporting herself with a walking frame.
SpecialtyGeriatrics

Frailty is a common geriatric syndrome that embodies an elevated risk of catastrophic declines in health and function among older adults. Frailty is a condition associated with ageing, and it has been recognized for centuries. It is also a marker of a more widespread syndrome of frailty, with associated weakness, slowing, decreased energy, lower activity, and, when severe, unintended weight loss. Frailty has been identified as a risk factor for the development of dementia.

As a population ages, a central focus of geriatricians and public health practitioners is to understand, and then beneficially intervene on, the factors and processes that put elders at such risk, especially the increased vulnerability to stressors (e.g. extremes of heat and cold, infection, injury, or even changes in medication) that characterizes many older adults.

Geriatric syndromes related to frailty

Sarcopenia

Sarcopenia is the degenerative loss of skeletal muscle mass, quality, and strength associated with aging. The rate of muscle loss is dependent on exercise level, co-morbidities, nutrition and other factors. Sarcopenia can lead to reduction in functional status and cause significant disability from increased weakness. The muscle loss is related to changes in muscle synthesis signalling pathways although is incompletely understood. The cellular mechanisms are distinct from other types of muscle atrophy such as cachexia, in which muscle is degraded through cytokine-mediated degradation although both conditions may co-exist.

Osteoporosis

Osteoporosis causes a hunched-over appearance in some people.

Osteoporosis is an age-related disease of bone that leads to an increased risk of fracture. In osteoporosis the bone mineral density (BMD) is reduced, bone microarchitecture is disrupted, and the amount and variety of proteins in bone is altered. Osteoporosis is defined by the World Health Organization (WHO) in women as a bone mineral density 2.5 standard deviations below peak bone mass (20-year-old healthy female average) as measured by DXA; the term "established osteoporosis" includes the presence of a fragility fracture.

Osteoporosis is most common in women after menopause, when it is called postmenopausal osteoporosis, but may also develop in men, and may occur in anyone in the presence of particular hormonal disorders and other chronic diseases or as a result of medications, specifically glucocorticoids, when the disease is called steroid- or glucocorticoid-induced osteoporosis (SIOP or GIOP). Given its influence in the risk of fragility fracture, osteoporosis may significantly affect life expectancy and quality of life.

Muscle weakness

Muscle weakness, also known as muscle fatigue, (or "lack of strength") refers to the inability to exert force with one's skeletal muscles. Weakness often follows muscle atrophy and a decrease in activity, such as after a long bout of bedrest as a result of an illness. There is also a gradual onset of muscle weakness as a result of sarcopenia – the age-related loss of skeletal muscle.

Muscle weakness makes it difficult to perform everyday activities, like getting into a bathtub.

A test of strength is often used during a diagnosis of a muscular disorder before the etiology can be identified. Such etiology depends on the type of muscle weakness, which can be true or perceived as well as variable topically. True weakness is substantial, while perceived rather is a sensation of having to put more effort to do the same task. On the other hand, various topic locations for muscle weakness are central, neural and peripheral. Central muscle weakness is an overall exhaustion of the whole body, while peripheral weakness is an exhaustion of individual muscles. Neural weakness is somewhere between.

Biological and physiological mechanisms

It has been suggested that the causes of frailty are multifactorial, involving dysregulation across many physiological systems. A proinflammatory state, sarcopenia, anemia, relative deficiencies in anabolic hormones (androgens and growth hormone) and excess exposure to catabolic hormones (cortisol), insulin resistance, glucose levels, compromised altered immune function, micronutrient deficiencies and oxidative stress are each individually associated with a higher likelihood of frailty. Additional findings show that the risk of frailty increases with an increased number of abnormal bodily systems. This finding shows that interventions that target multiple systems may yield greater results in prevention and treatment of frailty than interventions that target only one system.

Associations between specific disease states are also associated with and frailty have also been observed, including cardiovascular disease, diabetes mellitus, chronic kidney disease and other diseases in which inflammation is prominent. It is possible that clinically measurable disease states can manifest themselves or be captured prior to the onset of frailty. No single disease state is necessary and sufficient for the pathogenesis of frailty, since many individuals with chronic diseases are not frail. Therefore, rather than being dependent on the presence of measurable diseases, frailty is an expression of a critical mass of physiologic impairments. Frailty has been identified as a risk factor for the development of dementia.

Theoretical understanding

Recent work on frailty has sought to characterize both the underlying changes in the body and the manifestations that make frailty recognizable. It is well-agreed upon that declines in physiologic reserves and resilience is the essence of being frail. Similarly, scientists agree that the risk of frailty increases with age and with the incidence of diseases. Beyond that, there is now strong evidence to support the theory that the development of frailty involves declines in energy production, energy utilization and repair systems in the body, resulting in declines in the function of many different physiological systems. This decline in multiple systems affects the normal complex adaptive behavior that is essential to health and eventually results in frailty typically manifesting as a syndrome of a constellation of weakness, slowness, reduced activity, low energy and unintended weight loss. When most severe, i.e. when 3 or more of these manifestations are present, the individual is at a high risk of death.

Frailty assessment

The syndrome of geriatric frailty is hypothesized to reflect impairments in the regulation of multiple physiologic systems, embodying a lack of resilience to physiologic challenges and thus elevated risk for a range of deleterious endpoints. Generally speaking, the empirical assessment of geriatric frailty in individuals seeks ultimately to capture this or related features, though distinct approaches to such assessment have been developed in the literature (see de Vries et al., 2011 for a comprehensive review).

Two most widely used approaches, different in their nature and scopes, are discussed below. Other approaches follow.

Physical frailty phenotype

A popular approach to the assessment of geriatric frailty encompasses the assessment of five dimensions that are hypothesized to reflect systems whose impaired regulation underlies the syndrome. These five dimensions are:

  • unintentional weight loss,
  • exhaustion,
  • muscle weakness,
  • slowness while walking, and
  • low levels of activity.

Corresponding to these dimensions are five specific criteria indicating adverse functioning, which are implemented using a combination of self-reported and performance-based measures. Those who meet at least three of the criteria are defined as "frail", while those not matching any of the five criteria are defined as "robust". Additional work on the construct is done by Bandeen-Roche et al. (2006), though some of the exact criteria and measures differ (see Table 1 in the paper for this contrast). Other studies in the literature have also adopted the general approach of Linda P. Fried et al. (2001) though, again, the exact criteria and their particular measures may vary. This assessment approach was developed and refined by Fried and colleagues at the Johns Hopkins University's Center on Aging and Health. This center is home to Johns Hopkins Claude D. Pepper Older Americans Independence Center, which focuses on frailty research and has launched a website dedicated to frailty science: https://frailtyscience.org.

Frailty index / Deficit accumulation

Another notable approach to the assessment of geriatric frailty (if not also to some degree its conceptualization) is that of Rockwood and Mitnitski (2007) in which frailty is viewed in terms of the number of health "deficits" that are manifest in the individual, leading to a continuous measure of frailty (see Rockwood, Andrew, and Mitnitski (2007) for a contrast of the two approaches). This approach was developed by Dr. Rockwood and colleagues at Dalhousie University.

Four domains of frailty

A four domains of frailty model was proposed in response to an article in the BMJ. This conceptualisation could be viewed as blending the phenotypic and index models. Researchers tested this model for signal in routinely collected hospital data, and then used this signal in the development of a frailty model, finding even predictive capability across 3 outcomes of care. In the care home setting, one study indicated that not all four domains of frailty were routinely assessed in residents, giving evidence to suggest that frailty may still primarily be viewed only in terms of physical health.

SHARE Frailty Index

The SHARE-Frailty Index (SHARE-FI) was originally developed by Romero-Ortuno (2010) and researchers as part of the Survey of Healthy Ageing and Retirement in Europe. It consists of five domains of the frailty phenotype: •Fatigue •Loss of appetite •Grip strength •Functional difficulties •Physical activity

The SHARE-FI calculator is freely available to use online. The calculator classifies individuals as 1) frail; 2) pre-frail; and 3) non-frail / robust. The SHARE-FI has good clinical utility as it provides relatively quick assessment of frailty in often time-poor healthcare settings.

Prevention

Identification of risk factors

When considering prevention of frailty, it is important to understand the risk factors that contribute to frailty and identify them early on. A 2005 observational study found associations between frailty and a number of risk factors such as: low income, advanced age, chronic medical conditions, lack of education, and smoking.

Exercise

A significant target in the prevention of frailty is physical activity. As people age, physical activity markedly drops, with the steepest declines seen in adolescence and continuing on throughout life. The lower levels of physical activity and are associated with and a key component of frailty syndrome. Therefore, exercise regimens have been examined in a number of studies as an intervention to prevent frailty. A randomized control trial published in 2017 found significantly lower rates of frailty in older adults who were assigned an exercise regimen vs those who were in the control group. In this study, 15.3% of the control group became frail in the time frame of the study, in comparison to 4.9% of the exercise group. The exercise group also received a nutritional assessment, which is another target in frailty prevention.

Nutrition

Nutrition has also been a major target in the prevention of physical activity. A 2019 review paper examined a variety of studies and found evidence of nutritional intervention as an effective way of preventing frailty. With the mediterranean diet in particular reducing risk of frailty up to 60%.

Non-surgical management

Exercise

Individuals partaking in exercise appear to have potential in preventing frailty. In 2018, a systemic review concluded that group exercise had the benefit of delaying frailty in older adults aged 65 and above. Elderly adults are also less likely to sustain fall injuries.

Occupational therapy

Activities of daily living (ADLs) include activities that are necessary to sustain life. Examples are brushing teeth, getting out of bed, dressing oneself, bathing, etc. Occupational therapy provided modest improvements in elderly adults mobility to do ADLs.

Nutritional supplementation

Frailty can involve changes such as weight loss. Interventions should focus on any difficulties with supplementation and diet. For those who may be undernourished and not acquiring adequate calories, oral nutritional supplements in between meals may decrease nutritional deficits.

With age comes decreased bone density. Therefore, vitamin D supplementation may provide the benefits of improving stability and muscle strength retention.

Palliative care

Palliative care may be helpful for individuals who are experiencing an advanced state of frailty with possible other co-morbidities. Improving quality of life by reducing pain and other harmful symptoms is the goal with palliative care. One study showed the cost reduction by focusing on palliative care rather than expensive treatments that may be unnecessary and unhelpful.

Surgical outcomes

Frail elderly people are at significant risk of post-surgical complications and the need for extended care. Frailty more than doubles the risk of morbidity and mortality from surgery and cardiovascular conditions. Assessment of older patients before elective surgeries can accurately predict the patients' recovery trajectories. The most widely used frailty scale consists of five items:

  • unintentional weight loss >4.5 kg in the past year
  • self-reported exhaustion
  • <20th population percentile for grip strength
  • slowed walking speed, defined as lowest population quartile on 4-minute walking test
  • low physical activity such that persons would only rarely undertake a short walk

A healthy person scores 0; a very frail person scores 5. Compared to non-frail elderly people, people with intermediate frailty scores (2 or 3) are twice as likely to have post-surgical complications, spend 50% more time in the hospital, and are three times as likely to be discharged to a skilled nursing facility instead of to their own homes. Frail elderly patients (score of 4 or 5) have even worse outcomes, with the risk of being discharged to a nursing home rising to twenty times the rate for non-frail elderly people.

Epidemiology and public health

Frailty is a common geriatric syndrome. Estimates of frailty prevalence in older populations may vary according to a number of factors, including the setting in which the prevalence is being estimated – e.g., nursing home (higher prevalence) vs. community (lower prevalence) – and the operational definition used for defining frailty. Using the widely used frailty phenotype framework proposed by Fried et al. (2001), prevalence estimates of 7–16% have been reported in non-institutionalized, community-dwelling older adults.

The occurrence of frailty increases incrementally with advancing age, is more common in older women than men, and among those of lower socio-economic status. Frail older adults are at high risk for major adverse health outcomes, including disability, falls, institutionalization, hospitalization, and mortality.

Epidemiologic research to date has led to the identification of a number of risk factors for frailty, including: (a) chronic diseases, such as cardiovascular disease, diabetes, chronic kidney disease, depression, and cognitive impairment; (b) physiologic impairments, such as activation of inflammation and coagulation systems, anemia, atherosclerosis, autonomic dysfunction, hormonal abnormalities, obesity, hypovitaminosis D in men, and environment-related factors such as life space and neighborhood characteristics. Advances about potentially modifiable risk factors for frailty now offer the basis for translational research effort aimed at prevention and treatment of frailty in older adults. A recent systematic review found that exercise interventions can increase muscle strength and improve physical function; however, results are inconsistent in frail older adults living in the community.

A review looked at the relationship between the frailty syndrome and chronic lower extremity ischemia in those people with diabetes. On the one hand, chronic lower limb ischemia may predispose to the development of frailty, on the other hand, the presence of the frailty may affect the prognosis in patients with peripheral arterial disease.

Ongoing clinical trials

As of September 2021, ongoing clinical trials on frailty syndrome in the US include:

  • the impact of frailty on clinical outcomes of patients treated for abdominal aortic aneurysms
  • the use of "pre-habilitation," an exercise regimen used before transplant surgery, to prevent the frailty effects of kidney transplant in recipients
  • defining the acute changes in frailty following sepsis in the abdomen
  • the efficacy of the anti-inflammatory drug, Fisetin, in reducing frailty markers in elderly adults

Up-to-date information on ongoing clinical trials on frailty syndrome and other conditions can be found at clinicaltrials.gov.

Operator (computer programming)

From Wikipedia, the free encyclopedia https://en.wikipedia.org/wiki/Operator_(computer_programmin...