From Wikipedia, the free encyclopedia
The
impact of nanotechnology extends from its
medical,
ethical,
mental, legal and
environmental applications, to fields such as engineering, biology, chemistry, computing, materials science, and communications.
Major benefits of nanotechnology include improved manufacturing methods, water purification systems, energy systems,
physical enhancement,
nanomedicine, better food production methods, nutrition and large-scale infrastructure auto-fabrication.
[1]
Nanotechnology's reduced size may allow for automation of tasks which
were previously inaccessible due to physical restrictions, which in turn
may reduce labor, land, or maintenance requirements placed on humans.
Potential risks include environmental, health, and safety issues;
transitional effects such as displacement of traditional industries as
the products of nanotechnology become dominant, which are of concern to
privacy rights advocates. These may be particularly important if
potential negative effects of nanoparticles are overlooked.
Whether
nanotechnology merits special government
regulation is a controversial issue. Regulatory bodies such as the
United States Environmental Protection Agency
and the Health and Consumer Protection Directorate of the European
Commission have started dealing with the potential risks of
nanoparticles. The organic food sector has been the first to act with
the regulated exclusion of engineered nanoparticles from certified
organic produce, firstly in
Australia and the
UK,
[2] and more recently in
Canada, as well as for all food certified to
Demeter International standards
[3]
Overview
The presence of nanomaterials (materials that contain
nanoparticles)
is not in itself a threat. It is only certain aspects that can make
them risky, in particular their mobility and their increased reactivity.
Only if certain properties of certain nanoparticles were harmful to
living beings or the environment would we be faced with a genuine
hazard. In this case it can be called nanopollution.
In addressing the health and environmental impact of
nanomaterials we need to differentiate between two types of
nanostructures: (1) Nanocomposites, nanostructured surfaces and
nanocomponents (electronic, optical, sensors etc.), where nanoscale
particles are incorporated into a substance, material or device (“fixed”
nano-particles); and (2) “free” nanoparticles, where at some stage in
production or use individual nanoparticles of a substance are present.
These free nanoparticles could be nanoscale species of elements, or
simple compounds, but also complex compounds where for instance a
nanoparticle of a particular element is coated with another substance
(“coated” nanoparticle or “core-shell” nanoparticle).
There seems to be consensus that, although one should be aware of
materials containing fixed nanoparticles, the immediate concern is with
free nanoparticles.
Nanoparticles are very different from their everyday
counterparts, so their adverse effects cannot be derived from the known
toxicity of the macro-sized material. This poses significant issues for
addressing the health and environmental impact of free nanoparticles.
To complicate things further, in talking about nanoparticles it
is important that a powder or liquid containing nanoparticles almost
never be monodisperse, but contain instead a range of particle sizes.
This complicates the experimental analysis as larger nanoparticles might
have different properties from smaller ones. Also, nanoparticles show a
tendency to aggregate, and such aggregates often behave differently
from individual nanoparticles.
Health impact
A video on the health and safety implications of nanotechnology
The health impacts of
nanotechnology are the possible effects that the use of nanotechnological materials and devices will have on
human health.
As nanotechnology is an emerging field, there is great debate
regarding to what extent nanotechnology will benefit or pose risks for
human health. Nanotechnology's health impacts can be split into two
aspects: the potential for nanotechnological innovations to have
medical applications to cure disease, and the potential health hazards posed by exposure to
nanomaterials.
Medical applications
Nanomedicine is the
medical application of
nanotechnology.
[4] The approaches to nanomedicine range from the medical use of
nanomaterials, to
nanoelectronic biosensors, and even possible future applications of
molecular nanotechnology. Nanomedicine seeks to deliver a valuable set of research tools and clinically helpful devices in the near future.
[5][6] The
National Nanotechnology Initiative
expects new commercial applications in the pharmaceutical industry that
may include advanced drug delivery systems, new therapies, and
in vivo imaging.
[7] Neuro-electronic interfaces and other
nanoelectronics-based sensors are another active goal of research. Further down the line, the
speculative field of
molecular nanotechnology believes that
cell repair machines could revolutionize medicine and the medical field.
Nanomedicine research is directly funded, with the US
National Institutes of Health in 2005 funding a five-year plan to set up four nanomedicine centers. In April 2006, the journal
Nature Materials estimated that 130 nanotech-based drugs and delivery systems were being developed worldwide.
[8]
Nanomedicine is a large industry, with nanomedicine sales reaching
$6.8 billion in 2004. With over 200 companies and 38 products worldwide,
a minimum of $3.8 billion in nanotechnology
R&D is being invested every year.
[9] As the nanomedicine industry continues to grow, it is expected to have a significant impact on the economy.
Health hazards
Nanotoxicology is the field which studies potential health risks of
nanomaterials. The extremely small size of nanomaterials means that
they are much more readily taken up by the human body than larger sized
particles. How these nanoparticles behave inside the organism is one of
the significant issues that needs to be resolved. The behavior of
nanoparticles is a function of their size, shape and surface reactivity
with the surrounding tissue. Apart from what happens if non-degradable
or slowly degradable nanoparticles accumulate in organs, another concern
is their potential interaction with biological processes inside the
body: because of their large surface, nanoparticles on exposure to
tissue and fluids will immediately
adsorb
onto their surface some of the macromolecules they encounter. The
large number of variables influencing toxicity means that it is
difficult to generalise about health risks associated with exposure to
nanomaterials – each new nanomaterial must be assessed individually and
all material properties must be taken into account. Health and
environmental issues combine in the workplace of companies engaged in
producing or using nanomaterials and in the laboratories engaged in
nanoscience and nanotechnology research. It is safe to say that current
workplace exposure standards for dusts cannot be applied directly to
nanoparticle dusts.
The extremely small size of nanomaterials also means that they
are much more readily taken up by the human body than larger sized
particles. How these nanoparticles behave inside the body is one of the
issues that needs to be resolved. The behavior of nanoparticles is a
function of their size, shape and surface reactivity with the
surrounding tissue. They could cause overload on
phagocytes,
cells that ingest and destroy foreign matter, thereby triggering stress
reactions that lead to inflammation and weaken the body’s defense
against other pathogens. Apart from what happens if non-degradable or
slowly degradable nanoparticles accumulate in organs, another concern is
their potential interaction with biological processes inside the body:
because of their large surface, nanoparticles on exposure to tissue and
fluids will immediately
adsorb
onto their surface some of the macromolecules they encounter. This may,
for instance, affect the regulatory mechanisms of enzymes and other
proteins.
The
National Institute for Occupational Safety and Health
has conducted initial research on how nanoparticles interact with the
body’s systems and how workers might be exposed to nano-sized particles
in the manufacturing or industrial use of nanomaterials. NIOSH currently
offers interim guidelines for working with nanomaterials consistent
with the best scientific knowledge.
[10] At
The National Personal Protective Technology Laboratory of NIOSH, studies investigating the filter penetration of nanoparticles on NIOSH-certified and EU marked
respirators, as well as non-certified
dust masks have been conducted.
[11] These studies found that the most penetrating
particle size
range was between 30 and 100 nanometers, and leak size was the largest
factor in the number of nanoparticles found inside the respirators of
the test dummies.
[12][13]
Other properties of nanomaterials that influence toxicity
include: chemical composition, shape, surface structure, surface charge,
aggregation and solubility,
[14]
and the presence or absence of
functional groups of other chemicals.
[15]
The large number of variables influencing toxicity means that it is
difficult to generalise about health risks associated with exposure to
nanomaterials – each new nanomaterial must be assessed individually and
all material properties must be taken into account.
Literature reviews have been showing that release of engineered
nanoparticles and incurred personal exposure can happen during different
work activities.
[16][17][18] The situation alerts regulatory bodies to necessitate prevention strategies and regulations at nanotechnology workplaces.
Environmental impact
The
environmental impact of nanotechnology is the possible effects that the
use of nanotechnological materials and devices will have on
the environment.
[19] As nanotechnology is an emerging field, there is debate regarding to what extent industrial and commercial use of
nanomaterials will affect organisms and ecosystems.
Nanotechnology's environmental impact can be split into two
aspects: the potential for nanotechnological innovations to help improve
the environment, and the possibly novel type of pollution that
nanotechnological materials might cause if released into the
environment.
Environmental applications
Green nanotechnology refers to the use of
nanotechnology to enhance the environmental sustainability of processes producing
negative externalities. It also refers to the use of the products of nanotechnology to enhance
sustainability.
It includes making green nano-products and using nano-products in
support of sustainability. Green nanotechnology has been described as
the development of
clean technologies,
"to minimize potential environmental and human health risks associated
with the manufacture and use of nanotechnology products, and to
encourage replacement of existing products with new nano-products that
are more environmentally friendly throughout their
lifecycle."
[20]
Green nanotechnology has two goals: producing
nanomaterials
and products without harming the environment or human health, and
producing nano-products that provide solutions to environmental
problems. It uses existing principles of
green chemistry and green engineering
[21]
to make nanomaterials and nano-products without toxic ingredients, at
low temperatures using less energy and renewable inputs wherever
possible, and using lifecycle thinking in all design and engineering
stages.
Pollution
Nanopollution is a generic name for all waste generated by
nanodevices or during the
nanomaterials
manufacturing process. Nanowaste is mainly the group of particles that
are released into the environment, or the particles that are thrown away
when still on their products.
Social impact
Beyond the toxicity risks to human health and the environment which
are associated with first-generation nanomaterials, nanotechnology has
broader societal impact and poses broader social challenges. Social
scientists have suggested that nanotechnology's social issues should be
understood and assessed not simply as "downstream" risks or impacts.
Rather, the challenges should be factored into "upstream" research and
decision-making in order to ensure technology development that meets
social objectives
[22]
Many social scientists and organizations in civil society suggest that
technology assessment and governance should also involve public participation
[23][24][25][26]
Over 800 nano-related patents were granted in 2003, with numbers increasing to nearly 19,000 internationally by 2012.
[27]
Corporations are already taking out broad-ranging patents on nanoscale
discoveries and inventions. For example, two corporations,
NEC and
IBM, hold the basic patents on
carbon nanotubes,
one of the current cornerstones of nanotechnology. Carbon nanotubes
have a wide range of uses, and look set to become crucial to several
industries from electronics and computers, to strengthened materials to
drug delivery and diagnostics. Carbon nanotubes are poised to become a
major traded commodity with the potential to replace major conventional
raw materials.
[28]
Nanotechnologies may provide new solutions for the millions of people in
developing countries who lack access to basic services, such as safe water, reliable energy, health care, and education. The 2004
UN
Task Force on Science, Technology and Innovation noted that some of the
advantages of nanotechnology include production using little labor,
land, or maintenance, high productivity, low cost, and modest
requirements for materials and energy. However, concerns are frequently
raised that the claimed benefits of nanotechnology will not be evenly
distributed, and that any benefits (including technical and/or economic)
associated with nanotechnology will only reach affluent nations.
[29]
Longer-term concerns center on the impact that new technologies
will have for society at large, and whether these could possibly lead to
either a
post-scarcity
economy, or alternatively exacerbate the wealth gap between developed
and developing nations. The effects of nanotechnology on the society as a
whole, on human health and the environment, on trade, on security, on
food systems and even on the definition of "human", have not been
characterized or politicized.
Regulation
Significant debate exists relating to the question of whether
nanotechnology or nanotechnology-based
products merit special government
regulation.
This debate is related to the circumstances in which it is necessary
and appropriate to assess new substances prior to their release into the
market, community and environment.
Regulatory bodies such as the
United States Environmental Protection Agency and the
Food and Drug Administration
in the U.S. or the Health & Consumer Protection Directorate of the
European Commission have started dealing with the potential risks posed
by nanoparticles. So far, neither engineered nanoparticles nor the
products and materials that contain them are subject to any special
regulation regarding production, handling or labelling. The
Material Safety Data Sheet
that must be issued for some materials often does not differentiate
between bulk and nanoscale size of the material in question and even
when it does these MSDS are advisory only.
Limited nanotechnology labeling and regulation may exacerbate
potential human and environmental health and safety issues associated
with nanotechnology.
[30]
It has been argued that the development of comprehensive regulation of
nanotechnology will be vital to ensure that the potential risks
associated with the research and commercial application of
nanotechnology do not overshadow its potential benefits.
[31]
Regulation may also be required to meet community expectations about
responsible development of nanotechnology, as well as ensuring that
public interests are included in shaping the development of
nanotechnology.
[32]
In "The Consumer Product Safety Commission and Nanotechnology," E. Marla Felcher suggests that the
Consumer Product Safety Commission,
which is charged with protecting the public against unreasonable risks
of injury or death associated with consumer products, is ill-equipped to
oversee the safety of complex, high-tech products made using
nanotechnology.