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Sunday, October 13, 2019

Prevention of mental disorders

From Wikipedia, the free encyclopedia
Prevention of mental disorders are measures that try to decrease the chances of a mental disorder occurring. A 2004 WHO report stated that "prevention of these disorders is obviously one of the most effective ways to reduce the [disease] burden." The 2011 European Psychiatric Association (EPA) guidance on prevention of mental disorders states "There is considerable evidence that various psychiatric conditions can be prevented through the implementation of effective evidence-based interventions." A 2011 UK Department of Health report on the economic case for mental health promotion and mental illness prevention found that "many interventions are outstandingly good value for money, low in cost and often become self-financing over time, saving public expenditure". In 2016, the National Institute of Mental Health re-affirmed prevention as a research priority area.

Methods

Parenting

Parenting may affect the child's mental health, and evidence suggests that helping parents to be more effective with their children can address mental health needs.

Assessing parenting capability has been raised in child protection and other contexts. Delaying of potential very young pregnancies could lead to better mental health causal risk factors such as improved parenting skills and more stable homes, and various approaches have been used to encourage such behaviour change. Some countries run conditional cash transfer welfare programs where payment is conditional on behaviour of the recipients. Compulsory contraception has been used to prevent future mental illness.

Pre-emptive CBT

Use of cognitive behavioral therapy (CBT) with people at risk has significantly reduced the number of episodes of generalized anxiety disorder and other anxiety symptoms, and also given significant improvements in explanatory style, hopelessness, and dysfunctional attitudes. In 2014 the UK National Institute for Health and Care Excellence (NICE) recommended preventive CBT for people at risk of psychosis. As of 2018, some health providers now advocate pre-emptive use of CBT to prevent worsening of mental illnesses.

Mental silence meditation

Sahaja meditators scored above control groups for emotional well-being and mental health measures on SF-36 ratings, leading to proposed use for mental illness prevention, although this result could be due to meditators having other characteristics leading to good mental health, such as higher general self care.

Internet- and mobile-based interventions

A review found that a number of studies have shown that internet- and mobile-based interventions can be effective in preventing mental disorders.

Specific diseases

Depression

For depressive disorders, when people participated in interventions, some studies show the number of new cases is reduced by 22% to 38%. These interventions included CBT. Such interventions also save costs. Depression prevention continues to be called for.

Anxiety

  • use of cognitive behavioral therapy (CBT) with people at risk has significantly reduced the number of episodes of generalized anxiety disorder and other anxiety symptoms, and also given significant improvements in explanatory style, hopelessness, and dysfunctional attitudes. Other interventions (parental inhibition reduction, behaviourism, parental modelling, problem-solving and communication skills) have also produced significant benefits. People with subthreshold panic disorder were found to benefit from use of CBT.
  • for older people, a stepped-care intervention (watchful waiting, CBT and medication if appropriate) achieved a 50% lower incidence rate of depression and anxiety disorders in a patient group aged 75 or older.
  • for younger people, it has been found that teaching CBT in schools reduced anxiety in children, and a review found that most universal, selective and indicated prevention programs are effective in reducing symptoms of anxiety in children and adolescents.
  • for university students mindfulness has been shown to reduce subsequent anxiety.

Psychosis

In those at high risk there is tentative evidence that psychosis incidence may be reduced with the use of CBT or other types of therapy. In 2014 the UK National Institute for Health and Care Excellence (NICE) recommended preventive CBT for people at risk of psychosis.

There is also tentative evidence that treatment may help those with early symptoms. Antipsychotic medications are not recommended for preventing psychosis.

For schizophrenia, one study of preventative CBT showed a positive effect and another showed neutral effect.

Targeted vs universal

There has been an historical trend among public health professionals to consider targeted programmes. However identification of high risk groups can increase stigma, in turn meaning that the targeted people do not engage. Thus policy recommends universal programs, with resources within such programs weighted towards high risk groups.

Universal prevention (aimed at a population that has no increased risk for developing a mental disorder, such as school programs or mass media campaigns) need very high numbers of people to show effect (sometimes known as the "power" problem). Approaches to overcome this are (1) focus on high-incidence groups (e.g. by targeting groups with high risk factors), (2) use multiple interventions to achieve greater, and thus more statistically valid, effects, (3) use cumulative meta-analyses of many trials, and (4) run very large trials.

History

History of mental illness prevention strategies

  • In 2018 the University of Birmingham Mental Health Policy Commission focused on prevention, including the challenges of funding given the shortness of political cycles versus the longer paybacks of prevention.
  • In 2018 11 European researchers published a review of mental illness prevention stating that "Increasing evidence suggests that preventive interventions in psychiatry that are feasible, safe, and cost-effective could translate into a broader focus on prevention in our field." and that "Gaps between knowledge, policy, and practice need to be bridged."
  • In 2018 Massachusetts announced a mental health strategy including many prevention elements. The executive summary began "Behavioral health promotion and upstream prevention works."
  • In 2017 the Australian Government funded a new Centre for Research Excellence in Prevention of Anxiety and Depression.
  • The US Substance Abuse and Mental Health Services Administration (SAMHSA) advocates a 5-step prevention framework.
  • In 2016:
    • the UK NHS Mental Health Taskforce included 'preventing mental health' in its 3 Priorities, focusing on children and young ages, and the importance of employment.
    • the UK NGO Mental Health Foundation published a review of prevention approaches.
    • the UK NGO Mind produced public mental health recommendations for more prevention.
  • In 2015:
    • the Hunter Institute of mental health in Australia published its "Prevention First" strategic framework for prevention.
    • the UK NGO Mental Health Foundation published a review of prevention research, paving the way for prevention strategies.
    • the official journal of the World Psychiatric Association included a survey of public mental health which concluded "the evidence base for public mental health interventions is convincing, and the time is now ripe to move from knowledge to action".
  • In 2014 the UK Chief Medical Officer, Professor Dame Sally Davies, chose mental health for her major annual report, and included prevention of mental illness heavily in this.
  • In 2013 the Faculty of Public Health, the UK professional body for public health professionals, produced its "Better Mental Health for All" resource, which aims at "the promotion of mental wellbeing and the primary prevention of mental illness".
  • In 2012, Mind, the UK mental health NGO, included "Staying well; Support people likely to develop mental health problems, to stay well." as its first goal for 2012–16.
  • The 2011 mental health strategy of Manitoba (Canada) included intents to (i) reduce risk factors associated with mental ill-health and (ii) increase mental health promotion for both adults and children.
  • The 2011 US National Prevention Strategy included mental and emotional well-being, with recommendations including (i) better parenting and (ii) early intervention.
  • Australia's mental health plan for 2009–14 included "Prevention and Early Intervention" as priority 2.
  • The 2008 EU "Pact for Mental Health" made recommendations for youth and education including (i) promotion of parenting skills, (ii) integration of socio-emotional learning into education curricular and extracurricular activities, and (iii) early intervention throughout the educational system.
  • The 2006 Canadian "Out of the Shadows at last" included a section on prevention.

History of mental illness prevention programmes

Historically prevention has been a very small part of the spend of mental health systems. For instance the 2009 UK Department of Health analysis of prevention expenditure did not include any apparent spend on mental health. The situation is the same in research.

However more recently some prevention programmes have been proposed or implemented. Prevention programmes can include public health policies to raise general health, creating supportive environments, strengthening communities, developing personal skills, and reorienting services.
  • In 2017 the UK PHE and LSE produced research showing short payback periods for a number of prevention interventions.
  • In 2017 the Scotland Mental Health Strategy included prevention, including a focus on improving parenting skills.
  • In 2016, the UK Education Policy Institute advocated prevention through increased mental health literacy, better parenting and improving children's resilience and digital world skills.
  • In 2013 the UK NGO Mental Health Foundation and partners began to use Video Interaction Guidance (VIG) in an early years intervention to reduce later life mental illness.
  • In 2013 in Australia the National Health and Medical Research Council supported a set of parenting strategies to prevent teenagers becoming anxious or depressed.
  • In 2012 the UK Schizophrenia Commission recommended "a preventative strategy for psychosis including promoting protective factors for mental wellbeing and reducing risks such as cannabis use in early adolescence."
  • In 2010 the European Union DataPrev database was launched. It states "A healthy start is crucial for mental health and wellbeing throughout life, with parenting being the single most important factor," and recommends a range of interventions.
  • In 2009 the US National Academies publication on preventing mental, emotional, and behavioral disorders among young people focused on recent research and program experience and stated that "A number of promotion and prevention programs are now available that should be considered for broad implementation." A 2011 review of this by the authors said "A scientific base of evidence shows that we can prevent many mental, emotional, and behavioral disorders before they begin" and made recommendations including
    • supporting the mental health and parenting skills of parents,
    • encouraging the developmental competencies of children and
    • using preventive strategies particularly for children at risk (such as children of parents with mental illness, or with family stresses such as divorce or job loss).
In India the 1982 National Mental health Programme included prevention, but implementation has been slow, particularly of prevention elements.

It is already known that home visiting programs for pregnant women and parents of young children can produce replicable effects on children's general health and development in a variety of community settings. Similarly positive benefits from social and emotional education are well proven. Research has shown that risk assessment and behavioral interventions in pediatric clinics reduced abuse and neglect outcomes for young children. Early childhood home visitation also reduced abuse and neglect, but results were inconsistent.

Issues in implementation

Prevention programs can face issues in (i) ownership, because health systems are typically targeted at current suffering, and (ii) funding, because program benefits come on longer timescales than the normal political and management cycle. Assembling collaborations of interested bodies appears to be an effective model for achieving sustained commitment and funding.

Saturday, October 12, 2019

Mumps

From Wikipedia, the free encyclopedia

Mumps
Other namesEpidemic parotitis
Mumps PHIL 130 lores.jpg
Child with mumps
SpecialtyInfectious disease
SymptomsFever, muscle pain, headache, feeling generally unwell, painful swelling of the parotid gland
ComplicationsMeningitis, pancreatitis, deafness, infertility (males)
Usual onset~17 days after exposure
Duration7–10 days
CausesMumps rubulavirus
Diagnostic methodViral culture, antibodies in the blood
PreventionMumps vaccine
TreatmentSupportive
MedicationPain medication, intravenous immunoglobulin
Prognosis1 in 10,000 die
FrequencyMore common in the developing world

Mumps is a viral disease caused by the mumps virus. Initial signs and symptoms often include fever, muscle pain, headache, poor appetite, and feeling generally unwell. This is then usually followed by painful swelling of one or both parotid salivary glands. Symptoms typically occur 16 to 18 days after exposure and resolve after 7 to 10 days. Symptoms are often more severe in adults than in children. About a third of people have mild or no symptoms. Complications may include meningitis (15%), pancreatitis (4%), inflammation of the heart, permanent deafness, and testicular inflammation, which uncommonly results in infertility. Women may develop ovarian swelling, but this does not increase the risk of infertility.

Mumps is highly contagious and spreads rapidly among people living in close quarters. The virus is transmitted by respiratory droplets or direct contact with an infected person. Only humans get and spread the disease. People are infectious from about 7 days before onset of parotid inflammation to about 8 days after. Once an infection has run its course, a person is typically immune for life. Reinfection is possible, but the ensuing infection tends to be mild. Diagnosis is usually suspected due to parotid swelling and can be confirmed by isolating the virus on a swab of the parotid duct. Testing for IgM antibodies in the blood is simple and may be useful; however, it can be falsely negative in those who have been immunized.

Mumps is preventable by two doses of the mumps vaccine. Most of the developed world includes it in their immunization programs, often in combination with measles, rubella, and varicella vaccine. Countries that have low immunization rates may see an increase in cases among older age groups and thus worse outcomes. No specific treatment is known. Efforts involve controlling symptoms with pain medication such as paracetamol (acetaminophen). Intravenous immunoglobulin may be useful in certain complications. Hospitalization may be required if meningitis or pancreatitis develops. About one in 10,000 people who are infected die.

Without immunization, about 0.1 to 1.0% of the population is affected per year. Widespread vaccination has resulted in a more than 90% decline in rates of disease. Mumps is more common in the developing world, where vaccination is less common. Outbreaks, however, may still occur in a vaccinated population. Before the introduction of a vaccine, mumps was a common childhood disease worldwide. Larger outbreaks of disease typically occurred every 2 to 5 years. Children between the ages of 5 and 9 were most commonly affected. Among immunized populations, those in their early 20s often are affected. Around the equator, it often occurs all year round, while in the more northerly and southerly regions of the world, it is more common in the winter and spring. Painful swelling of the parotid glands and testicles was described by Hippocrates in the fifth century BCE.

Signs and symptoms

Mumps is usually preceded by a set of prodromal symptoms, including low-grade fever, headache, and feeling generally unwell. This is followed by progressive swelling of one or both parotid glands. Parotid gland swelling usually lasts about a week. Other symptoms of mumps can include dry mouth, sore face and/or ears, and difficulty speaking.

Complications

  • Painful testicular inflammation develops in 15–40% of men who have completed puberty and contract the mumps virus. This testicular inflammation is generally one-sided (both testicles are swollen in 15–30% of mumps orchitis cases) and typically occurs about 10 days after the parotid gland becomes inflamed. Testicular swelling has been documented as late as 6 weeks after parotid-gland swelling. Decreased fertility is an uncommon consequence of testicular inflammation from mumps and infertility is rare.
  • Studies have reached differing conclusions regarding whether infection with the mumps virus during pregnancy leads to an increased rate of spontaneous abortion.
  • Before vaccination, about 10% of cases of aseptic meningitis were due to mumps. The symptoms generally resolve within 10 days. Infection of the brain itself (encephalitis) occurs in between 0.02 and 0.3% of cases.
  • Ovarian inflammation occurs in about 5% percent of adolescent and adult females.
  • Acute pancreatic inflammation occurs in about 4% percent of cases, manifesting as abdominal pain and vomiting.
  • Brain inflammation is very rare, and fatal in about 1% of the cases when it occurs.
  • Profound (91 dB or more) but rare sensorineural hearing loss can occur, which can be uni- or bilateral. Acute unilateral deafness occurs in about 0.005% of cases.

Cause

The mumps virus is an enveloped, single-stranded, linear negative-sense RNA virus of the genus Rubulavirus and family Paramyxovirus. The genome consists of 15,384 bases encoding nine proteins. Proteins involved in viral replication are the nucleoprotein, phosphoprotein, and polymerase protein while the genomic RNA forms the ribonucleocapsid. Humans are the only natural host for the virus. 

Mumps is spread from person to person through contact with respiratory secretions, such as saliva from an infected person. When an infected person coughs or sneezes, the droplets aerosolize and can enter the eyes, nose, or mouth of another person. Mumps can also be spread by sharing eating utensils or cups. The virus can also survive on surfaces and then be spread after contact in a similar manner. A person infected with mumps is contagious from around 7 days before the onset of symptoms until about 8 days after symptoms start. The incubation period (time until symptoms begin) can be from 12–25 days, but is typically 16–18 days. About 20-40% of persons infected with the mumps virus do not show symptoms, so being infected and spreading the virus without knowing it is possible.

Diagnosis

During an outbreak, a diagnosis can be made by determining recent exposure and parotitis. However, when the disease incidence is low, other infectious causes of parotitis should be considered, such as HIV, coxsackievirus, and influenza. Some viruses such as enteroviruses may cause aseptic meningitis that is very clinically similar to mumps.

A physical examination confirms the presence of the swollen glands. Usually, the disease is diagnosed on clinical grounds, and no confirmatory laboratory testing is needed. If uncertainty exists about the diagnosis, a test of saliva or blood may be carried out; a newer diagnostic confirmation, using real-time nested polymerase chain reaction technology, has also been developed. As with any inflammation of the salivary glands, the serum level of the enzyme amylase is often elevated.

Prevention

The most common preventive measure against mumps is a vaccination with a mumps vaccine, invented by American microbiologist Maurice Hilleman at Merck. The vaccine may be given separately or as part of the MMR vaccine or MMRV vaccine. The World Health Organization (WHO) recommends the use of mumps vaccines in all countries with well-functioning childhood vaccination programmes. In the United Kingdom, they are routinely given to children at age 13 months with a booster at 3–5 years (preschool). The American Academy of Pediatrics recommends the routine administration of MMR vaccine at ages 12–15 months and at 4–6 years. In some locations, the vaccine is given again between 4 and 6 years of age, or between 11 and 12 years of age if not previously given. The efficacy of the vaccine depends on its strain, but is usually around 80%. The Jeryl Lynn strain is most commonly used in developed countries, but has been shown to have reduced efficacy in epidemic situations. The Leningrad-Zagreb strain commonly used in developing countries appears to have superior efficacy in epidemic situations.

Because of the outbreaks within college and university settings, many governments have established vaccination programs to prevent large-scale outbreaks. In Canada, provincial governments and the Public Health Agency of Canada have all participated in awareness campaigns to encourage students ranging from grade one to college and university to get vaccinated.

The WHO, the American Academy of Pediatrics, the Advisory Committee on Immunization Practices of the Centers for Disease Control and Prevention, the American Academy of Family Physicians, the British Medical Association, and the Royal Pharmaceutical Society of Great Britain recommend routine vaccination of children against mumps. General mumps vaccination with MMR began in the United Kingdom in 1988.

Before the introduction of the mumps vaccine, the mumps virus was the leading cause of viral meningoencephalitis in the United States. However, encephalitis occurs rarely (less than two per 100,000). In one of the largest studies in the literature, the most common symptoms of mumps meningoencephalitis were found to be fever (97%), vomiting (94%), and headache (88.8%). The mumps vaccine was introduced into the United States in December 1967: since its introduction, a steady decrease in the incidence of mumps has occurred, with 151,209 cases of mumps reported in 1968. From 2001 to 2008, the case average was only 265 per year, excluding an outbreak of less than 6000 cases in 2006 attributed largely to university contagion in young adults.

Management

The treatment of mumps is supportive. Symptoms may be relieved by the application of intermittent ice or heat to the affected neck/testicular area and by acetaminophen for pain relief. Warm saltwater gargles, soft foods, and extra fluids may also help relieve symptoms. Acetylsalicylic acid (aspirin) is not used to treat children due to the risk of Reye syndrome.

No effective postexposure recommendation is made to prevent secondary transmission, nor is the postexposure use of vaccine or immunoglobulin effective.

Mumps is considered most contagious in the 5 days after the onset of symptoms, and isolation is recommended during this period. In someone who has been admitted to the hospital, standard and droplet precautions are needed. People who work in healthcare cannot work for 5 days.

Epidemiology

In the United States, typically between a few hundred and few thousand cases occur in a year.

History

Mumps has been known to humans since antiquity. It was mentioned by Hippocrates in his Of the Epidemics written in 400 BC, wherein he described the painful swelling of the parotid glands and testicles. The disease was first described scientifically as late as 1790 by a British physician Robert Hamilton (1721–1793) in the Transactions of the Royal Society of Edinburgh. The disease was one of the most medically significant diseases among the armies involved in the fighting both World War I and World War II. A number of attempts to prove that mumps is contagious failed. Its contagiousness was finally proved in 1934 by Claude D. Johnson and Ernest William Goodpasture (1886–1960), who demonstrated that mumps was transmitted by a filterable virus.

Population history of indigenous peoples of the Americas

From Wikipedia, the free encyclopedia
 
1857 engraving of a sick Native American being cared for by an indigenous healer
Contemporary illustration of the 1868 Washita Massacre by the 7th Cavalry against Black Kettle's band of Cheyennes, during the American Indian Wars. Violence and conflict with colonists were also important causes of the decline of certain indigenous American populations since the 16th century.
 
The population figure of indigenous peoples of the Americas before the 1492 Spanish voyage of Christopher Columbus has proven difficult to establish. Scholars rely on archaeological data and written records from European settlers. Most scholars writing at the end of the 19th century estimated that the pre-Columbian population was as low as 10 million; by the end of the 20th century most scholars gravitated to a middle estimate of around 50 million, with some historians arguing for an estimate of 100 million or more. Contact with the Europeans led to the European colonization of the Americas, in which millions of immigrants from Europe eventually settled in the Americas.

The population of African and Eurasian peoples in the Americas grew steadily, while the indigenous population plummeted. Eurasian diseases such as influenza, pneumonic plagues, and smallpox devastated the Native Americans, who did not have immunity to them. Conflict and outright warfare with Western European newcomers and other American tribes further reduced populations and disrupted traditional societies. The extent and causes of the decline have long been a subject of academic debate, along with its characterization as a genocide.

Population overview

Given the fragmentary nature of the evidence, even semi-accurate pre-Columbian population figures are impossible to obtain. Scholars have varied widely on the estimated size of the indigenous populations prior to colonization and on the effects of European contact. Estimates are made by extrapolations from small bits of data. In 1976, geographer William Denevan used the existing estimates to derive a "consensus count" of about 54 million people. Nonetheless, more recent estimates still range widely.

Using an estimate of approximately 37 million people in Mexico, Central and South America in 1492 (including 6 million in the Aztec Empire, 5-10 million in the Mayan States, 11 million in what is now Brazil, and 12 million in the Inca Empire), the lowest estimates give a death toll due from disease of 80% by the end of the 17th century (nine million people in 1650). Latin America would match its 15th-century population early in the 19th century; it numbered 17 million in 1800, 30 million in 1850, 61 million in 1900, 105 million in 1930, 218 million in 1960, 361 million in 1980, and 563 million in 2005. In the last three decades of the 16th century, the population of present-day Mexico dropped to about one million people. The Maya population is today estimated at six million, which is about the same as at the end of the 15th century, according to some estimates. In what is now Brazil, the indigenous population declined from a pre-Columbian high of an estimated four million to some 300,000. 

While it is difficult to determine exactly how many Natives lived in North America before Columbus, estimates range from a low of 2.1 million to 7 million people to a high of 18 million.

The aboriginal population of Canada during the late 15th century is estimated to have been between 200,000 and two million, with a figure of 500,000 currently accepted by Canada's Royal Commission on Aboriginal Health. Repeated outbreaks of Old World infectious diseases such as influenza, measles and smallpox (to which they had no natural immunity), were the main cause of depopulation. This combined with other factors such as dispossession from European/Canadian settlements and numerous violent conflicts resulted in a forty- to eighty-percent aboriginal population decrease after contact. For example, during the late 1630s, smallpox killed over half of the Wyandot (Huron), who controlled most of the early North American fur trade in what became Canada. They were reduced to fewer than 10,000 people.

Historian David Henige has argued that many population figures are the result of arbitrary formulas selectively applied to numbers from unreliable historical sources. He believes this is a weakness unrecognized by several contributors to the field, and insists there is not sufficient evidence to produce population numbers that have any real meaning. He characterizes the modern trend of high estimates as "pseudo-scientific number-crunching." Henige does not advocate a low population estimate, but argues that the scanty and unreliable nature of the evidence renders broad estimates inevitably suspect, saying "high counters" (as he calls them) have been particularly flagrant in their misuse of sources. Many population studies acknowledge the inherent difficulties in producing reliable statistics, given the scarcity of hard data.

The population debate has often had ideological underpinnings. Low estimates were sometimes reflective of European notions of cultural and racial superiority. Historian Francis Jennings argued, "Scholarly wisdom long held that Indians were so inferior in mind and works that they could not possibly have created or sustained large populations."

The indigenous population of the Americas in 1492 was not necessarily at a high point and may actually have been in decline in some areas. Indigenous populations in most areas of the Americas reached a low point by the early 20th century. In most cases, populations have since begun to climb.

Pre-Columbian Americas

Genetic diversity and population structure in the American land mass using DNA micro-satellite markers (genotype) sampled from North, Central, and South America have been analyzed against similar data available from other indigenous populations worldwide. The Amerindian populations show a lower genetic diversity than populations from other continental regions. Observed is both a decreasing genetic diversity as geographic distance from the Bering Strait occurs and a decreasing genetic similarity to Siberian populations from Alaska (genetic entry point). Also observed is evidence of a higher level of diversity and lower level of population structure in western South America compared to eastern South America. A relative lack of differentiation between Mesoamerican and Andean populations is a scenario that implies coastal routes were easier than inland routes for migrating peoples (Paleo-Indians) to traverse. The overall pattern that is emerging suggests that the Americas were recently colonized by a small number of individuals (effective size of about 70-250), and then they grew by a factor of 10 over 800 – 1000 years. The data also show that there have been genetic exchanges between Asia, the Arctic and Greenland since the initial peopling of the Americas. A new study in early 2018 suggests that the effective population size of the original founding population of Native Americans was about 250 people.

Depopulation from disease

Sixteenth-century Aztec drawings of victims of smallpox (above) and measles (below)
 

Graph demonstrating the population collapse in Central Mexico brought on by successive epidemics in the early colonial period.
 
According to Noble David Cook, a community of scholars has recently, albeit slowly, "been quietly accumulating piece by piece data on early epidemics in the Americas and their relation to the subjugation of native peoples." They now believe that widespread epidemic disease, to which the natives had no prior exposure or resistance, was the primary cause of the massive population decline of the Native Americans. Earlier explanations for the population decline of the American natives include the European immigrants' accounts of the brutal practices of the Spanish conquistadores, as recorded by the Spaniards themselves. This was applied through the encomienda, which was a system ostensibly set up to protect people from warring tribes as well as to teach them the Spanish language and the Catholic religion, but in practice was tantamount to serfdom and slavery. The most notable account was that of the Dominican friar Bartolomé de las Casas, whose writings vividly depict Spanish atrocities committed in particular against the Taínos. It took five years for the Taíno rebellion to be quelled by both the Real Audiencia—through diplomatic sabotage, and through the Indian auxiliaries fighting with the Spanish. After Emperor Charles V personally eradicated the notion of the encomienda system as a use for slave labour, there were not enough Spanish to have caused such a large population decline. The second European explanation was a perceived divine approval, in which God removed the natives as part of His "divine plan" to make way for a new Christian civilization. Many Native Americans viewed their troubles in terms of religious or supernatural causes within their own belief systems.

Soon after Europeans and enslaved Africans arrived in the New World, bringing with them the infectious diseases of Europe and Africa, observers noted immense numbers of indigenous Americans began to die from these diseases. One reason this death toll was overlooked is that once introduced, the diseases raced ahead of European immigration in many areas. The disease killed a sizable portion of the populations before European written records were made. After the epidemics had already killed massive numbers of natives, many newer European immigrants assumed that there had always been relatively few indigenous peoples. The scope of the epidemics over the years was tremendous, killing millions of people—possibly in excess of 90% of the population in the hardest-hit areas—and creating one of "the greatest human catastrophe in history, far exceeding even the disaster of the Black Death of medieval Europe", which had killed up to one-third of the people in Europe and Asia between 1347 and 1351. 

One of the most devastating diseases was smallpox, but other deadly diseases included typhus, measles, influenza, bubonic plague, cholera, malaria, tuberculosis, mumps, yellow fever and pertussis, which were chronic in Eurasia.

This transfer of disease between the Old and New Worlds was later studied as part of what has been labeled the "Columbian Exchange". 

The epidemics had very different effects in different regions of the Americas. The most vulnerable groups were those with a relatively small population and few built-up immunities. Many island-based groups were annihilated. The Caribs and Arawaks of the Caribbean nearly ceased to exist, as did the Beothuks of Newfoundland. While disease raged swiftly through the densely populated empires of Mesoamerica, the more scattered populations of North America saw a slower spread.

The colonization of the Americas killed so many people it resulted in climate change and temporary global cooling, according to scientists from University College London. According to one of the researchers, UCL Geography Professor Mark Maslin, the large death toll also boosted the economies of Europe: "the depopulation of the Americas may have inadvertently allowed the Europeans to dominate the world. It also allowed for the Industrial Revolution and for Europeans to continue that domination."

Historian Andrés Reséndez of University of California, Davis asserts that evidence suggests "slavery has emerged as major killer" of the indigenous populations of the Caribbean between 1492 and 1550 rather than diseases such as smallpox, influenza and malaria. He posits that unlike the populations of Europe who rebounded following the Black Death, no such rebound occurred for the indigenous populations of the Americas. He concludes that, even though the Spanish were aware of deadly diseases such as smallpox, there is no mention of them in the New World until 1519, meaning perhaps they didn't spread as fast as initially believed, and that unlike Europeans, the indigenous populations were subjected to brutal forced labor in gold and silver mines on a massive scale. Anthropologist Jason Hickel of the London School of Economics estimates that a third of Arawak workers died every six months from lethal forced labor in these mines.

Historian David Stannard says that by "focusing almost entirely on disease . . . contemporary authors increasingly have created the impression that the eradication of those tens of millions of people was inadvertent - a sad, but both inevitable and "unintended consequence" of human migration and progress," and asserts that their destruction "was neither inadvertent not inevitable," but the result of microbial pestilence and purposeful genocide working in tandem.

Virulence and mortality

Viral and bacterial diseases that kill victims before the illnesses spread to others tend to flare up and then die out. A more resilient disease would establish an equilibrium; if its victims lived beyond infection, the disease would spread further. The evolutionary process selects against quick lethality, with the most immediately fatal diseases being the most short-lived. A similar evolutionary pressure acts upon victim populations, as those lacking genetic resistance to common diseases die and do not leave descendants, whereas those who are resistant procreate and pass resistant genes to their offspring. For example, in the first fifty years of the sixteenth century, an unusually strong strain of syphilis killed a high proportion of infected Europeans within a few months; over time, however, the disease has become much less virulent.

Thus both infectious diseases and populations tend to evolve towards an equilibrium in which the common diseases are non-symptomatic, mild or manageably chronic. When a population that has been relatively isolated is exposed to new diseases, it has no resistance to the new diseases (the population is "biologically naive"). These people die at a much higher rate, resulting in what is known as a "virgin soil" epidemic. Before the European arrival, the Americas had been isolated from the Eurasian-African landmass. The peoples of the Old World had had thousands of years for their populations to accommodate to their common diseases. 

The fact that all members of an immunologically naive population are exposed to a new disease simultaneously increases the fatalities. In populations where the disease is endemic, generations of individuals acquired immunity; most adults had exposure to the disease at a young age. Because they were resistant to reinfection, they are able to care for individuals who caught the disease for the first time, including the next generation of children. With proper care, many of these "childhood diseases" are often survivable. In a naive population, all age groups are affected at once, leaving few or no healthy caregivers to nurse the sick. With no resistant individuals healthy enough to tend to the ill, a disease may have higher fatalities. 

The natives of the Americas were faced with several new diseases at once creating a situation where some who successfully resisted one disease might die from another. Multiple simultaneous infections (e.g., smallpox and typhus at the same time) or in close succession (e.g., smallpox in an individual who was still weak from a recent bout of typhus) are more deadly than just the sum of the individual diseases. In this scenario, death rates can also be elevated by combinations of new and familiar diseases: smallpox in combination with American strains of yaws, for example. 

Other contributing factors:
  • Native American medical treatments such as sweat baths and cold water immersion (practiced in some areas) weakened some patients and probably increased mortality rates.
  • Europeans brought many diseases with them because they had many more domesticated animals than the Native Americans. Domestication usually means close and frequent contact between animals and people, which allows diseases of domestic animals to migrate into the human population when the necessary mutations occur.
  • The Eurasian landmass extends many thousands of miles along an east-west axis. Climate zones also extend for thousands of miles, which facilitated the spread of agriculture, domestication of animals, and the diseases associated with domestication. The Americas extend mainly north and south, which, according to the environmental determinist theory popularized by Jared Diamond in Guns, Germs, and Steel, meant that it was much harder for cultivated plant species, domesticated animals, and diseases to migrate.

Biological warfare

When Old World diseases were first carried to the Americas at the end of the fifteenth century, they spread throughout the southern and northern hemispheres, leaving the indigenous populations in near ruins. No evidence has been discovered that the earliest Spanish colonists and missionaries deliberately attempted to infect the American natives, and some effort was actually made to limit the devastating effects of disease before it killed off what remained of their forced slave labor under their encomienda system. The cattle introduced by the Spanish contaminated various water reserves which Native Americans dug in the fields to accumulate rainwater. In response, the Franciscans and Dominicans created public fountains and aqueducts to guarantee access to drinking water. But when the Franciscans lost their privileges in 1572, many of these fountains were no longer guarded and so deliberate well poisoning may have happened. Although no proof of such poisoning has been found, some historians believe the decrease of the population correlates with the end of religious orders' control of the water.

In the centuries that followed, accusations and discussions of biological warfare were common. Well-documented accounts of incidents involving both threats and acts of deliberate infection are very rare, but may have occurred more frequently than scholars have previously acknowledged. Many of the instances likely went unreported, and it is possible that documents relating to such acts were deliberately destroyed, or sanitized. By the middle of the 18th century, colonists had the knowledge and technology to attempt biological warfare with the smallpox virus. They well understood the concept of quarantine, and that contact with the sick could infect the healthy with smallpox, and those who survived the illness would not be infected again. Whether the threats were carried out, or how effective individual attempts were, is uncertain.

One such threat was delivered by fur trader James McDougall, who is quoted as saying to a gathering of local chiefs, "You know the smallpox. Listen: I am the smallpox chief. In this bottle I have it confined. All I have to do is to pull the cork, send it forth among you, and you are dead men. But this is for my enemies and not my friends." Likewise, another fur trader threatened Pawnee Indians that if they didn't agree to certain conditions, "he would let the smallpox out of a bottle and destroy them." The Reverend Isaac McCoy was quoted in his History of Baptist Indian Missions as saying that the white men had deliberately spread smallpox among the Indians of the southwest, including the Pawnee tribe, and the havoc it made was reported to General Clark and the Secretary of War. Artist and writer George Catlin observed that Native Americans were also suspicious of vaccination, "They see white men urging the operation so earnestly they decide that it must be some new mode or trick of the pale face by which they hope to gain some new advantage over them." So great was the distrust of the settlers that the Mandan chief Four Bears denounced the white man, whom he had previously treated as brothers, for deliberately bringing the disease to his people.

During the Seven Years' War, British militia took blankets from their smallpox hospital and gave them as gifts to two neutral Lenape Indian dignitaries during a peace settlement negotiation, according to the entry in the Captain's ledger, "To convey the Smallpox to the Indians". In the following weeks, the high commander of the British forces in North America conspired with his Colonel to "Extirpate this Execreble Race" of Native Americans, writing, "Could it not be contrived to send the small pox among the disaffected tribes of Indians? We must on this occasion use every stratagem in our power to reduce them." His Colonel agreed to try. Most scholars have asserted that the 1837 Great Plains smallpox epidemic was "started among the tribes of the upper Missouri River by failure to quarantine steamboats on the river", and Captain Pratt of the St. Peter "was guilty of contributing to the deaths of thousands of innocent people. The law calls his offense criminal negligence. Yet in light of all the deaths, the almost complete annihilation of the Mandans, and the terrible suffering the region endured, the label criminal negligence is benign, hardly befitting an action that had such horrendous consequences." However, some sources attribute the 1836–40 epidemic to the deliberate communication of smallpox to Native Americans, with historian Ann F. Ramenofsky writing, "Variola Major can be transmitted through contaminated articles such as clothing or blankets. In the nineteenth century, the U. S. Army sent contaminated blankets to Native Americans, especially Plains groups, to control the Indian problem." Well into the 20th century, deliberate infection attacks continued as Brazilian settlers and miners transported infections intentionally to the native groups whose lands they coveted."

Vaccination

After Edward Jenner's 1796 demonstration that the smallpox vaccination worked, the technique became better known and smallpox became less deadly in the United States and elsewhere. Many colonists and natives were vaccinated, although, in some cases, officials tried to vaccinate natives only to discover that the disease was too widespread to stop. At other times, trade demands led to broken quarantines. In other cases, natives refused vaccination because of suspicion of whites. The first international healthcare expedition in history was the Balmis expedition which had the aim of vaccinating indigenous peoples against smallpox all along the Spanish Empire in 1803. In 1831, government officials vaccinated the Yankton Sioux at Sioux Agency. The Santee Sioux refused vaccination and many died.

Depopulation from European Conquest

War and violence

Storming of the Teocalli by Cortez and His Troops by Emanuel Leutze
 
While epidemic disease was a leading factor of the population decline of the American indigenous peoples after 1492, there were other contributing factors, all of them related to European contact and colonization. One of these factors was warfare. According to demographer Russell Thornton, although many lives were lost in wars over the centuries, and war sometimes contributed to the near extinction of certain tribes, warfare and death by other violent means was a comparatively minor cause of overall native population decline.

From the U.S. Bureau of the Census in 1894: "The Indian wars under the government of the United States have been more than 40 in number [Over the previous 100 years]. They have cost the lives of about 19,000 white men, women and children, including those killed in individual combats, and the lives of about 30,000 Indians. The actual number of killed and wounded Indians must be very much higher than the given... Fifty percent additional would be a safe estimate..."

There is some disagreement among scholars about how widespread warfare was in pre-Columbian America, but there is general agreement that war became deadlier after the arrival of the Europeans and their firearms. The South or Central American infrastructure allowed for thousands of European conquistadors and tens of thousands of their Indian auxiliaries to attack the dominant indigenous civilization. Empires such as the Incas depended on a highly centralized administration for the distribution of resources. Disruption caused by the war and the colonization hampered the traditional economy, and possibly led to shortages of food and materials. The Arauco War, Chichimeca War, Red Cloud's War, Seminole Wars, War of 1812, Pontiac's Rebellion, Beaver Wars, French-Indian War, American Civil War, American Revolution, Modoc War, Oka Crisis, Battle of Cut Knife, all represented either pyrrhic victories by colonial forces, outright defeat, military stalemates, or further alliance-politics. Across the western hemisphere, war with various Native American civilizations constituted alliances based out of both necessity or economic prosperity and, resulted in mass-scale intertribal warfare. European colonization in the North American continent also contributed to a number of wars between Native Americans, who fought over which of them should have first access to new technology and weaponry—like in the Beaver Wars.

Exploitation

Some Spaniards objected to the encomienda system, notably Bartolomé de las Casas, who insisted that the Indians were humans with souls and rights. Due to many revolts and military encounters, Emperor Charles V helped relieve the strain on both the Indian laborers and the Spanish vanguards probing the Caribana for military and diplomatic purposes. Later on New Laws were promulgated in Spain in 1542 to protect isolated natives, but the abuses in the Americas were never entirely or permanently abolished. The Spanish also employed the pre-Columbian draft system called the mita, and treated their subjects as something between slaves and serfs. Serfs stayed to work the land; slaves were exported to the mines, where large numbers of them died. In other areas the Spaniards replaced the ruling Aztecs and Incas and divided the conquered lands among themselves ruling as the new feudal lords with often, but unsuccessful lobbying to the viceroys of the Spanish crown to pay Tlaxcalan war demnities. The infamous Bandeirantes from São Paulo, adventurers mostly of mixed Portuguese and native ancestry, penetrated steadily westward in their search for Indian slaves. Serfdom existed as such in parts of Latin America well into the 19th century, past independence.

Massacres

Friar Bartolomé de las Casas and Antonius Flávio Chesta (Tony Chesta) and other dissenting Spaniards from the colonial period described the manner in which the natives were treated by colonials. This has helped to create an image of the Spanish conquistadores as cruel in the extreme.

Great revenues were drawn from Hispaniola so the advent of losing manpower didn't benefit the Spanish crown. At best, the reinforcement of vanguards sent by the Council of the Indies to explore the Caribana country and gather information on alliances or hostilities was the main goal of the local viceroys and their adelantados. Although mass killings and atrocities were not a significant factor in native depopulation, no mainstream scholar dismisses the sometimes humiliating circumstances now believed to be precipitated by civil disorder as well as Spanish cruelty.
  • The Pequot War in early New England.
  • In mid-19th century Argentina, post-independence leaders Juan Manuel de Rosas and Julio Argentino Roca engaged in what they presented as a "Conquest of the Desert" against the natives of the Argentinian interior, leaving over 1,300 indigenous dead.
  • While some California tribes were settled on reservations, others were hunted down and massacred by 19th century American settlers. It is estimated that at least 9,400 to 16,000 California Indians were killed by non-Indians, mostly occurring in more than 370 massacres (defined as the "intentional killing of five or more disarmed combatants or largely unarmed noncombatants, including women, children, and prisoners, whether in the context of a battle or otherwise").

Displacement and disruption

The populations of many Native American peoples were reduced by the common practice of intermarrying with Europeans. Although many Indian cultures that once thrived are extinct today, their descendants exist today in some of the bloodlines of the current inhabitants of the Americas.

Formal apology from the United States government

On 8 September 2000, the head of the United States Bureau of Indian Affairs (BIA) formally apologized for the agency's participation in the "ethnic cleansing" of Western tribes. In a speech before representatives of Native American peoples in June, 2019, California governor Gavin Newsom apologized for the California Genocide. Newsom said, "That’s what it was, a genocide. No other way to describe it. And that’s the way it needs to be described in the history books."

Connected car

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