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Monday, June 1, 2020

Indonesia

From Wikipedia, the free encyclopedia

Republic of Indonesia

Republik Indonesia  (Indonesian)
Motto: Bhinneka Tunggal Ika (Old Javanese)
(English: "Unity in Diversity")
National ideology: Pancasila[1][2]
Indonesia (orthographic projection).svg
Capital
and largest city
Jakarta
6°10′S 106°49′E
Official language
and national language
Indonesian
Regional languages
Over 700 languages
Ethnic groups Over 300 ethnic groups
Religion
(2010)
Demonym(s)Indonesian
GovernmentUnitary presidential constitutional republic

• President
Joko Widodo
Ma'ruf Amin
Puan Maharani
Muhammad Syarifuddin
LegislaturePeople's Consultative Assembly (MPR)
Regional Representative Council (DPD)
People's Representative Council (DPR)
Formation

2nd century
13th century
20 March 1602
1 January 1800
9 March 1942
17 August 1945
27 December 1949
• Unitary republic
17 August 1950
Area
• Land
1,904,569 km2 (735,358 sq mi)
• Water (%)
4.85
Population
• 2018 estimate
267,670,543
• 2010 census
237,641,326
• Density
138/km2 (357.4/sq mi)
GDP (PPP)2019 estimate
• Total
$3.740 trillion
• Per capita
$14,840
GDP (nominal)2019 estimate
• Total
$1.200 trillion
• Per capita
$4,460
Gini (2018)Positive decrease 39.0
medium
HDI (2018)Increase 0.707
high · 111th
CurrencyIndonesian rupiah (Rp) (IDR)
Time zoneUTC+7 to +9 (various)
Date formatDD/MM/YYYY
Driving sideleft
Calling code+62
ISO 3166 codeID
Internet TLD.id

Indonesia, officially the Republic of Indonesia, is a country in Southeast Asia and Oceania, between the Indian and Pacific oceans. It consists of more than seventeen thousand islands, including Sumatra, Java, Borneo (Kalimantan), Sulawesi, and New Guinea (Papua). Indonesia is the world's largest island country and the 14th largest country by land area, at 1,904,569 square kilometres (735,358 square miles). With over 267 million people, it is the world's 4th most populous country as well as the most populous Muslim-majority country. Java, the world's most populous island, is home to more than half of the country's population.

The sovereign state is a presidential, constitutional republic with an elected legislature. It has 34 provinces, of which five have special status. The country's capital, Jakarta, is the second-most populous urban area in the world. The country shares land borders with Papua New Guinea, East Timor, and the eastern part of Malaysia. Other neighbouring countries include Singapore, Vietnam, the Philippines, Australia, Palau, and India's Andaman and Nicobar Islands. Despite its large population and densely populated regions, Indonesia has vast areas of wilderness that support one of the world's highest levels of biodiversity.

The Indonesian archipelago has been a valuable region for trade since at least the 7th century when Srivijaya and later Majapahit traded with entities from mainland China and the Indian subcontinent. Local rulers gradually absorbed foreign influences from the early centuries and Hindu and Buddhist kingdoms flourished. Sunni traders and Sufi scholars brought Islam, while Europeans introduced Christianity through colonisation. Although sometimes interrupted by the Portuguese, French and British, the Dutch were the foremost colonial power for much of their 350-year presence in the archipelago. The concept of "Indonesia" as a nation-state emerged in the early 20th century and the country proclaimed its independence in 1945. However, it was not until 1949 that the Dutch recognised Indonesia's sovereignty following an armed and diplomatic conflict between the two.

Indonesia consists of hundreds of distinct native ethnic and linguistic groups, with the largest one being the Javanese. A shared identity has developed with the motto "Bhinneka Tunggal Ika" ("Unity in Diversity" literally, "many, yet one"), defined by a national language, ethnic diversity, religious pluralism within a Muslim-majority population, and a history of colonialism and rebellion against it. The economy of Indonesia is the world's 16th largest by nominal GDP and 7th by GDP at PPP. The country is a member of several multilateral organisations, including the United Nations, World Trade Organization, International Monetary Fund, G20, and a founding member of Non-Aligned Movement, Association of Southeast Asian Nations, Asia-Pacific Economic Cooperation, East Asia Summit, Asian Infrastructure Investment Bank, and Organisation of Islamic Cooperation.

Etymology

The name Indonesia derives from Greek Indos (Ἰνδός) and the word nesos (νῆσος), meaning "Indian islands". The name dates to the 18th century, far predating the formation of independent Indonesia. In 1850, George Windsor Earl, an English ethnologist, proposed the terms Indunesians—and, his preference, Malayunesians—for the inhabitants of the "Indian Archipelago or Malayan Archipelago". In the same publication, one of his students, James Richardson Logan, used Indonesia as a synonym for Indian Archipelago. However, Dutch academics writing in East Indies publications were reluctant to use Indonesia; they preferred Malay Archipelago (Dutch: Maleische Archipel); the Netherlands East Indies (Nederlandsch Oost Indië), popularly Indië; the East (de Oost); and Insulinde.

After 1900, Indonesia became more common in academic circles outside the Netherlands, and native nationalist groups adopted it for political expression. Adolf Bastian, of the University of Berlin, popularised the name through his book Indonesien oder die Inseln des Malayischen Archipels, 1884–1894. The first native scholar to use the name was Ki Hajar Dewantara when in 1913 he established a press bureau in the Netherlands, Indonesisch Pers-bureau.

History

Early history

A Borobudur ship carved on Borobudur temple, c. 800 CE. Outrigger boats from the archipelago may have made trade voyages to the east coast of Africa as early as the 1st century CE.

Fossilised remains of Homo erectus, popularly known as the "Java Man", suggest the Indonesian archipelago was inhabited two million to 500,000 years ago. Homo sapiens reached the region around 43,000 BCE. Austronesian peoples, who form the majority of the modern population, migrated to Southeast Asia from what is now Taiwan. They arrived in the archipelago around 2,000 BCE and confined the native Melanesian peoples to the far eastern regions as they spread east. Ideal agricultural conditions and the mastering of wet-field rice cultivation as early as the eighth century BCE allowed villages, towns, and small kingdoms to flourish by the first century CE. The archipelago's strategic sea-lane position fostered inter-island and international trade, including with Indian kingdoms and Chinese dynasties, from several centuries BCE. Trade has since fundamentally shaped Indonesian history.

From the seventh century CE, the Srivijaya naval kingdom flourished as a result of trade and the influences of Hinduism and Buddhism. Between the eighth and tenth centuries CE, the agricultural Buddhist Sailendra and Hindu Mataram dynasties thrived and declined in inland Java, leaving grand religious monuments such as Sailendra's Borobudur and Mataram's Prambanan. The Hindu Majapahit kingdom was founded in eastern Java in the late 13th century, and under Gajah Mada, its influence stretched over much of present-day Indonesia. This period is often referred to as a "Golden Age" in Indonesian history.

The earliest evidence of Islamized populations in the archipelago dates to the 13th century in northern Sumatra. Other parts of the archipelago gradually adopted Islam, and it was the dominant religion in Java and Sumatra by the end of the 16th century. For the most part, Islam overlaid and mixed with existing cultural and religious influences, which shaped the predominant form of Islam in Indonesia, particularly in Java.

Colonial era

The submission of Prince Diponegoro to General De Kock at the end of the Java War in 1830

The first Europeans arrived in the archipelago in 1512, when Portuguese traders, led by Francisco Serrão, sought to monopolise the sources of nutmeg, cloves, and cubeb pepper in the Maluku Islands. Dutch and British traders followed. In 1602, the Dutch established the Dutch East India Company (VOC) and became the dominant European power for almost 200 years. The VOC was dissolved in 1800 following bankruptcy, and the Netherlands established the Dutch East Indies as a nationalised colony.

For most of the colonial period, Dutch control over the archipelago was tenuous. Dutch forces were engaged continuously in quelling rebellions both on and off Java. The influence of local leaders such as Prince Diponegoro in central Java, Imam Bonjol in central Sumatra, Pattimura in Maluku, and bloody 30-year war in Aceh weakened the Dutch and tied up the colonial military forces. Only in the early 20th century did their dominance extend to what was to become Indonesia's current boundaries.

The Japanese invasion and subsequent occupation during World War II ended Dutch rule and encouraged the previously suppressed independence movement. Two days after the surrender of Japan in August 1945, Sukarno and Mohammad Hatta, influential nationalist leaders, proclaimed Indonesian independence and were appointed president and vice-president respectively. The Netherlands attempted to re-establish their rule, and a bitter armed and diplomatic struggle ended in December 1949 when the Dutch formally recognised Indonesian independence in the face of international pressure. Despite extraordinary political, social and sectarian divisions, Indonesians, on the whole, found unity in their fight for independence.

Modern era

Sukarno (left) and Hatta (right), Indonesia's founding fathers and the first President and Vice President

As president, Sukarno moved Indonesia from democracy towards authoritarianism and maintained power by balancing the opposing forces of the military, political Islam, and the increasingly powerful Communist Party of Indonesia (PKI). Tensions between the military and the PKI culminated in an attempted coup in 1965. The army, led by Major General Suharto, countered by instigating a violent anti-communist purge that killed between 500,000 and one million people. The PKI was blamed for the coup and effectively destroyed. Suharto capitalised on Sukarno's weakened position, and following a drawn-out power play with Sukarno, Suharto was appointed president in March 1968. His "New Order" administration, supported by the United States, encouraged foreign direct investment, which was a crucial factor in the subsequent three decades of substantial economic growth. 

Indonesia was the country hardest hit by the 1997 Asian financial crisis. It brought out popular discontent with the New Order's corruption and suppression of political opposition and ultimately ended Suharto's presidency. In 1999, East Timor seceded from Indonesia, following its 1975 invasion by Indonesia and a 25-year occupation that was marked by international condemnation of human rights abuses.

In the post-Suharto era, democratic processes have been strengthened by enhancing regional autonomy and instituting the country's first direct presidential election in 2004. Political, economic and social instability, corruption, and terrorism remained problems in the 2000s; however, in recent years, the economy has performed strongly. Although relations among the diverse population are mostly harmonious, acute sectarian discontent and violence remain a problem in some areas. A political settlement to an armed separatist conflict in Aceh was achieved in 2005 following the 2004 Indian Ocean earthquake and tsunami that killed 130,000 Indonesians. In 2014, Joko Widodo became the first directly elected president from outside the military and political elite.

Geography

Mount Semeru and Mount Bromo in East Java. Indonesia's seismic and volcanic activity is among the world's highest.
 
Indonesia lies between latitudes 11°S and 6°N, and longitudes 95°E and 141°E. It is the largest archipelagic country in the world, extending 5,120 kilometres (3,181 mi) from east to west and 1,760 kilometres (1,094 mi) from north to south. According to the country's Coordinating Ministry for Maritime Affairs, Indonesia has 17,504 islands (16,056 of which are registered at the UN), scattered over both sides of the equator, around 6,000 of which are inhabited. The largest are Java, Sumatra, Borneo (shared with Brunei and Malaysia), Sulawesi, and New Guinea (shared with Papua New Guinea). Indonesia shares land borders with Malaysia on Borneo, Papua New Guinea on the island of New Guinea, and East Timor on the island of Timor, and maritime borders with Singapore, Malaysia, Vietnam, the Philippines, Palau, and Australia.

At 4,884 metres (16,024 ft), Puncak Jaya is Indonesia's highest peak, and Lake Toba in Sumatra is the largest lake, with an area of 1,145 km2 (442 sq mi). Indonesia's largest rivers are in Kalimantan and New Guinea and include Kapuas, Barito, Mamberamo, Sepik and Mahakam. They serve as communication and transport links between the island's river settlements.

Climate

Typical Indonesian rainforest, mostly found in Kalimantan and Sumatra

Indonesia lies along the equator, and its climate tends to be relatively even year-round. Indonesia has two seasons—a wet season and a dry season—with no extremes of summer or winter. For most of Indonesia, the dry season falls between May and October with the wet season between November and April. Indonesia's climate is almost entirely tropical, dominated by the tropical rainforest climate found in every large island of Indonesia. More cooling climate types do exist in mountainous regions that are 1,300 to 1,500 metres (4,300 to 4,900 feet) above sea level. The oceanic climate (Köppen Cfb) prevails in highland areas adjacent to rainforest climates, with reasonably uniform precipitation year-round. In highland areas near the tropical monsoon and tropical savanna climates, the subtropical highland climate (Köppen Cwb) is prevalent with a more pronounced dry season. 

Some regions, such as Kalimantan and Sumatra, experience only slight differences in rainfall and temperature between the seasons, whereas others, such as Nusa Tenggara, experience far more pronounced differences with droughts in the dry season, and floods in the wet. Rainfall varies across regions, with more in western Sumatra, Java, and the interiors of Kalimantan and Papua, and less in areas closer to Australia, such as Nusa Tenggara, which tend to be dry. The almost uniformly warm waters that constitute 81% of Indonesia's area ensure that temperatures on land remain relatively constant. Humidity is quite high, at between 70 and 90%. Winds are moderate and generally predictable, with monsoons usually blowing in from the south and east in June through October, and from the northwest in November through March. Typhoons and large-scale storms pose little hazard to mariners; significant dangers come from swift currents in channels, such as the Lombok and Sape straits.

Geology

A chart with the heading "Major Volcanoes of Indonesia (with eruptions since 1900 A.D.)". Depicted below the heading is an overhead view of a cluster of islands.
Major volcanoes in Indonesia. Indonesia is in the Pacific Ring of Fire area.
 
Tectonically, Indonesia is highly unstable, making it a site of numerous volcanoes and frequent earthquakes. It lies on the Pacific Ring of Fire where the Indo-Australian Plate and the Pacific Plate are pushed under the Eurasian plate where they melt at about 100 kilometres (62 miles) deep. A string of volcanoes runs through Sumatra, Java, Bali and Nusa Tenggara, and then to the Banda Islands of Maluku to northeastern Sulawesi. Of the 400 volcanoes, around 130 are active. Between 1972 and 1991, there were 29 volcanic eruptions, mostly on Java. Volcanic ash has made agricultural conditions unpredictable in some areas. However, it has also resulted in fertile soils, a factor in historically sustaining high population densities of Java and Bali.

A massive supervolcano erupted at present-day Lake Toba around 70,000 BCE. It is believed to have caused a global volcanic winter and cooling of the climate, and subsequently led to a genetic bottleneck in human evolution, though this is still in debate. The 1815 eruption of Mount Tambora and the 1883 eruption of Krakatoa were among the largest in recorded history. The former caused 92,000 deaths and created an umbrella of volcanic ash which spread and blanketed parts of the archipelago, and made much of Northern Hemisphere without summer in 1816. The latter produced the loudest sound in recorded history and caused 36,000 deaths due to the eruption itself and the resulting tsunamis, with significant additional effects around the world years after the event. Recent catastrophic disasters due to seismic activity include the 2004 Indian Ocean earthquake and the 2006 Yogyakarta earthquake.

Biodiversity

Species endemic to Indonesia. Clockwise from top: Rafflesia arnoldii, orangutan, greater bird-of-paradise, and Komodo dragon.
 
Indonesia's size, tropical climate, and archipelagic geography support one of the world's highest levels of biodiversity. Its flora and fauna is a mixture of Asian and Australasian species. The islands of the Sunda Shelf (Sumatra, Java, Borneo, and Bali) were once linked to mainland Asia, and have a wealth of Asian fauna. Large species such as the Sumatran tiger, rhinoceros, orangutan, Asian elephant, and leopard were once abundant as far east as Bali, but numbers and distribution have dwindled drastically. Having been long separated from the continental landmasses, Sulawesi, Nusa Tenggara, and Maluku have developed their unique flora and fauna. Papua was part of the Australian landmass and is home to a unique fauna and flora closely related to that of Australia, including over 600 bird species. Forests cover approximately 70% of the country. However, the forests of the smaller, and more densely populated Java, have largely been removed for human habitation and agriculture.

Indonesia is second only to Australia in terms of total endemic species, with 36% of its 1,531 species of bird and 39% of its 515 species of mammal being endemic. Tropical seas surround Indonesia's 80,000 kilometres (50,000 miles) of coastline. The country has a range of sea and coastal ecosystems, including beaches, dunes, estuaries, mangroves, coral reefs, seagrass beds, coastal mudflats, tidal flats, algal beds, and small island ecosystems. Indonesia is one of Coral Triangle countries with the world's most enormous diversity of coral reef fish with more than 1,650 species in eastern Indonesia only.

British naturalist Alfred Russel Wallace described a dividing line (Wallace Line) between the distribution of Indonesia's Asian and Australasian species. It runs roughly north–south along the edge of the Sunda Shelf, between Kalimantan and Sulawesi, and along the deep Lombok Strait, between Lombok and Bali. Flora and fauna on the west of the line are generally Asian, while east from Lombok they are increasingly Australian until the tipping point at the Weber Line. In his 1869 book, The Malay Archipelago, Wallace described numerous species unique to the area. The region of islands between his line and New Guinea is now termed Wallacea.

Environment


Indonesia's large and growing population and rapid industrialisation present serious environmental issues. They are often given a lower priority due to high poverty levels and weak, under-resourced governance. Problems include the destruction of peatlands, large-scale illegal deforestation—and the resulting Southeast Asian haze—over-exploitation of marine resources, air pollution, garbage management, and reliable water and wastewater services. These issues contribute to Indonesia's poor ranking (number 133 out of 180 countries) in the 2018 Environmental Performance Index. The report also indicates that Indonesia's performance is among the lowest in the Asia-Pacific region.

Expansion of the palm oil industry requiring significant changes to the natural ecosystems is the one primary factor behind much of Indonesia's deforestation. While it can generate wealth for local communities, it may degrade ecosystems and cause social problems. This situation makes Indonesia the world's largest forest-based emitter of greenhouse gases. It also threatens the survival of indigenous and endemic species. The International Union for Conservation of Nature (IUCN) identified 140 species of mammals as threatened, and 15 as critically endangered, including the Bali starling, Sumatran orangutan, and Javan rhinoceros.

Several studies consider Indonesia to be at severe risk from the projected effects of climate change. They predict that unreduced emissions would see an average temperature rise of around 1 °C (2 °F) by mid-century, amounting to almost double the frequency of scorching days (above 35 °C or 95 °F) per year by 2030. That figure is predicted to rise further by the end of the century. It would raise the frequency of drought and food shortages, having an impact on precipitation and the patterns of wet and dry seasons, the basis of Indonesia's agricultural system. It would also encourage diseases and increases in wildfires, which threaten the country's enormous rainforest. Rising sea levels, at current rates, would result in tens of millions of households being at risk of submersion by mid-century. A majority of Indonesia's population lives in low-lying coastal areas, including the capital Jakarta, the fastest sinking city in the world. Impoverished communities would likely be affected the most by climate change.

Government and politics

A presidential inauguration by the MPR in the Parliament Complex Jakarta, 2014

Indonesia is a republic with a presidential system. Following the fall of the New Order in 1998, political and governmental structures have undergone sweeping reforms, with four constitutional amendments revamping the executive, legislative and judicial branches. Chief among them is the delegation of power and authority to various regional entities while remaining a unitary state. The President of Indonesia is the head of state and head of government, commander-in-chief of the Indonesian National Armed Forces (Tentara Nasional Indonesia, TNI), and the director of domestic governance, policy-making, and foreign affairs. The president may serve a maximum of two consecutive five-year terms.

The highest representative body at the national level is the People's Consultative Assembly (Majelis Permusyawaratan Rakyat, MPR). Its main functions are supporting and amending the constitution, inaugurating and impeaching the president, and formalising broad outlines of state policy. The MPR comprises two houses; the People's Representative Council (Dewan Perwakilan Rakyat, DPR), with 575 members, and the Regional Representative Council (Dewan Perwakilan Daerah, DPD), with 136. The DPR passes legislation and monitors the executive branch. Reforms since 1998 have markedly increased its role in national governance, while the DPD is a new chamber for matters of regional management.

Most civil disputes appear before the State Court (Pengadilan Negeri); appeals are heard before the High Court (Pengadilan Tinggi). The Supreme Court of Indonesia (Mahkamah Agung) is the highest level of the judicial branch, and hears final cessation appeals and conducts case reviews. Other courts include the Constitutional Court (Mahkamah Konstitusi) that listens to constitutional and political matters and the Religious Court (Pengadilan Agama) that deals with codified Islamic Law (sharia) cases. Additionally, the Judicial Commission (Komisi Yudisial) monitors the performance of judges.

Parties and elections

Since 1999, Indonesia has had a multi-party system. In all legislative elections since the fall of the New Order, no political party has managed to win an overall majority of seats. The Indonesian Democratic Party of Struggle (PDI-P), which secured the most votes in the 2019 elections, is the party of the incumbent President, Joko Widodo. Other notable parties include the Party of the Functional Groups (Golkar), the Great Indonesia Movement Party (Gerindra), the Democratic Party, and the Prosperous Justice Party (PKS). The 2019 elections resulted in nine political parties in the DPR, with a parliamentary threshold of 4% of the national vote. The first general election was held in 1955 to elect members of the DPR and the Constitutional Assembly (Konstituante). At the national level, Indonesians did not elect a president until 2004. Since then, the president is elected for a five-year term, as are the party-aligned members of the DPR and the non-partisan DPD. Beginning with 2015 local elections, elections for governors and mayors have occurred on the same date. As of 2019, both legislative and presidential elections coincide.

Administrative divisions

Indonesia has several levels of subdivisions. The first level is that of the provinces, with five out of a total of 34 having a special status. Each has a legislature (Dewan Perwakilan Rakyat Daerah, DPRD) and an elected governor. This number has evolved, with the most recent change being the split of North Kalimantan from East Kalimantan in 2012. The second level is that of the regencies (kabupaten) and cities (kota), led by regents (bupati) and mayors (walikota) respectively and a legislature (DPRD Kabupaten/Kota). The third level is that of the districts (kecamatan, distrik in Papua, or kapanewon and kemantren in Yogyakarta), and the fourth is of the villages (either desa, kelurahan, kampung, nagari in West Sumatra, or gampong in Aceh).

The village is the lowest level of government administration. It is divided into several community groups (rukun warga, RW), which are further divided into neighbourhood groups (rukun tetangga, RT). In Java, the village (desa) is divided into smaller units called dusun or dukuh (hamlets), which are the same as RW. Following the implementation of regional autonomy measures in 2001, regencies and cities have become chief administrative units, responsible for providing most government services. The village administration level is the most influential on a citizen's daily life and handles matters of a village or neighbourhood through an elected village chief (lurah or kepala desa).

Aceh, Jakarta, Yogyakarta, Papua, and West Papua have greater legislative privileges and a higher degree of autonomy from the central government than the other provinces. A conservative Islamic territory, Aceh has the right to create some aspects of an independent legal system implementing sharia. Yogyakarta is the only pre-colonial monarchy legally recognised in Indonesia, with the positions of governor and vice governor being prioritised for descendants of the Sultan of Yogyakarta and Paku Alam, respectively. Papua and West Papua are the only provinces where the indigenous people have privileges in their local government. Jakarta is the only city granted a provincial government due to its position as the capital of Indonesia.

Foreign relations


Indonesia maintains 132 diplomatic missions abroad, including 95 embassies. The country adheres to what it calls a "free and active" foreign policy, seeking a role in regional affairs in proportion to its size and location but avoiding involvement in conflicts among other countries.

Indonesia was a significant battleground during the Cold War. Numerous attempts by the United States and the Soviet Union, and China to some degree, culminated in the 1965 coup attempt and subsequent upheaval that led to a reorientation of foreign policy. Quiet alignment with the West while maintaining a non-aligned stance has characterised Indonesia's foreign policy since then. Today, it maintains close relations with its neighbours and is a founding member of the Association of Southeast Asian Nations (ASEAN) and the East Asia Summit. In common with most of the Muslim world, Indonesia does not have diplomatic relations with Israel and has actively supported Palestine. However, observers have pointed out that Indonesia has ties with Israel, albeit discreetly.

Indonesia has been a member of the United Nations since 1950 and was a founding member of the Non-Aligned Movement (NAM) and the Organisation of Islamic Cooperation (OIC). Indonesia is a signatory to the ASEAN Free Trade Area agreement, the Cairns Group, and the World Trade Organization (WTO), and an occasional member of OPEC. During the Indonesia–Malaysia confrontation, Indonesia withdrew from the UN due to the latter's election to the United Nations Security Council, although it returned 18 months later. It marked the first time in UN history that a member state had attempted a withdrawal. Indonesia has been a humanitarian and development aid recipient since 1966, and recently, the country has expressed interest in becoming an aid donor.

Military

Indonesian Armed Forces. Clockwise from top: Indonesian Army during training session, Sukhoi Su-30, Pindad Anoa, and Indonesian naval vessel KRI Sultan Iskandar Muda 367.
 
Indonesia's Armed Forces (TNI) include the Army (TNI–AD), Navy (TNI–AL, which includes Marine Corps), and Air Force (TNI–AU). The army has about 400,000 active-duty personnel. Defence spending in the national budget was 0.7% of GDP in 2018, with controversial involvement of military-owned commercial interests and foundations. The Armed Forces were formed during the Indonesian National Revolution when it undertook guerrilla warfare along with informal militia. Since then, territorial lines have formed the basis of all TNI branches' structure, aimed at maintaining domestic stability and deterring foreign threats. The military has possessed a strong political influence since its founding, which peaked during the New Order. Political reforms in 1998 included the removal of the TNI's formal representation from the legislature. Nevertheless, its political influence remains, albeit at a reduced level.

Since independence, the country has struggled to maintain unity against local insurgencies and separatist movements. Some, notably in Aceh and Papua, have led to an armed conflict, and subsequent allegations of human rights abuses and brutality from all sides. The former was resolved peacefully in 2005, while the latter continues, amid a significant, albeit imperfect, implementation of regional autonomy laws, and a reported decline in the levels of violence and human rights abuses since 2004. Other engagements of the army include the campaign against the Netherlands New Guinea to incorporate the territory into Indonesia, the Konfrontasi to oppose the creation of Malaysia, the mass killings of PKI, and the invasion of East Timor, which remains Indonesia's most massive military operation.

Economy

Jakarta, the capital city and the country's commercial centre

Indonesia has a mixed economy in which both the private sector and government play vital roles. As the only G20 member state in Southeast Asia, the country has the largest economy in the region and is classified as a newly industrialised country. As of 2019, it is the world's 16th largest economy by nominal GDP and 7th in terms of GDP at PPP, estimated to be US$1.100 trillion and US$3.740 trillion respectively. Per capita GDP in PPP is US$14,020, while nominal per capita GDP is US$4,120. The debt ratio to GDP is 29.2%. The services are the economy's largest sector and account for 43.4% of GDP (2018), followed by industry (39.7%) and agriculture (12.8%). Since 2009, it has employed more people than other sectors, accounting for 47.7% of the total labour force, followed by agriculture (30.2%) and industry (21.9%).

Vast palm oil plantation in Bogor, West Java. Currently, Indonesia is the world's largest producer of palm oil.
 
Over time, the structure of the economy has changed considerably. Historically, it has been weighted heavily towards agriculture, reflecting both its stage of economic development and government policies in the 1950s and 1960s to promote agricultural self-sufficiency. A gradual process of industrialisation and urbanisation began in the late 1960s and accelerated in the 1980s as falling oil prices saw the government focus on diversifying away from oil exports and towards manufactured exports. This development continued throughout the 1980s and into the next decade despite the 1990 oil price shock, during which the GDP rose at an average rate of 7.1%. As a result, the official poverty rate fell from 60% to 15%. Reduction of trade barriers from the mid-1980s made the economy more globally integrated. The growth, however, ended with the, which affected the economy severely. It caused a real GDP contraction by 13.1% in 1998, and inflation reached 72%. The economy reached its low point in mid-1999 with only 0.8% real GDP growth.

Relatively steady inflation and an increase in GDP deflator and the Consumer Price Index have contributed to strong economic growth in recent years. Since 2007, annual growth has accelerated to between 4% and 6% as a result of improvement in the banking sector and domestic consumption, helping Indonesia weather the 2008–2009 Great Recession. In 2011, the country regained the investment grade rating it had lost in 1997. As of 2019, 9.41% of the population lived below the poverty line, and the official open unemployment rate was 5.28%.

Indonesia has abundant natural resources like oil and natural gas, coal, tin, copper, gold, and nickel, while agriculture produces rice, palm oil, tea, coffee, cacao, medicinal plants, spices, and rubber. These commodities make up a large portion of the country's exports, with palm oil and coal briquettes as the leading export commodities. In addition to refined and crude petroleum as the main imports, telephones, vehicle parts and wheat cover the majority of additional imports. China, the United States, Japan, Singapore, India, Malaysia, South Korea and Thailand are Indonesia's principal export markets and import partners.

Transport

Major transport modes in Indonesia. Clockwise from top: TransJakarta bus, Jabodetabek Commuter Line, Garuda Indonesia Boeing 737-800, Pelni ship.
 
Indonesia's transport system has been shaped over time by the economic resource base of an archipelago, and the distribution of its 250 million people highly concentrated on Java. All transport modes play a role in the country's transport system and are generally complementary rather than competitive. In 2016, the transport sector generated about 5.2% of GDP.

The road transport system is predominant, with a total length of 542,310 kilometres (336,980 miles) as of 2018. Jakarta has the most extended bus rapid transit system in the world, boasting some 251.2 kilometres (156.1 miles) in 13 corridors and ten cross-corridor routes. Rickshaws such as bajaj and becak and share taxis such as Angkot and Metromini are a regular sight in the country. Most of the railways are in Java, used for both freight and passenger transport, such as local commuter rail services complementing the inter-city rail network in several cities. In the late 2010s, Jakarta and Palembang were the first cities in Indonesia to have rapid transit systems, with more planned for other cities in the future. In 2015, the government announced a plan to build a high-speed rail, which would be a first in Southeast Asia.

Indonesia's largest airport, Soekarno–Hatta International Airport is the busiest in the Southern Hemisphere, serving 66 million passengers in 2018. Ngurah Rai International Airport and Juanda International Airport are the country's second- and third-busiest airport respectively. Garuda Indonesia, the country's flag carrier since 1949, is one of the world's leading airlines and a member of the global airline alliance SkyTeam. Port of Tanjung Priok is the busiest and most advanced Indonesian port, handling more than 50% of Indonesia's trans-shipment cargo traffic.

Energy

In 2017, Indonesia was the world's 9th largest energy producer with 4,200 terawatt-hours (14.2 quadrillion British thermal units), and the 15th largest energy consumer, with 2,100 terawatt-hours (7.1 quadrillion British thermal units). The country has substantial energy resources, including 22 billion barrels (3.5 billion cubic metres) of conventional oil and gas reserves (of which about 4 billion barrels are recoverable), 8 billion barrels of oil-equivalent of coal-based methane (CBM) resources, and 28 billion tonnes of recoverable coal. While reliance on domestic coal and imported oil has increased, Indonesia has seen progress in renewable energy with hydropower being the most abundant source. Furthermore, the country has the potential for geothermal, solar, wind, biomass and ocean energy. Indonesia has set out to achieve 23% use of renewable energy by 2025 and 31% by 2050. As of 2015, Indonesia's total national installed power generation capacity stands at 55,528.51 MW.

The country's largest dam, Jatiluhur, has several purposes including the provision of hydroelectric power generation, water supply, flood control, irrigation and aquaculture. The earth-fill dam is 105 m (344 ft) high and withholds a reservoir of 3.0 billion m3 (2.4 million acre⋅ft). It helps to supply water to Jakarta and to irrigate 240,000 ha (590,000 acres) of rice fields and has an installed capacity of 186.5 MW which feeds into the Java grid managed by the State Electricity Company (Perusahaan Listrik Negara, PLN).

Science and technology

Palapa satellite launch in 1984
 
Indonesia's expenditure on science and technology is relatively low, at less than 0.1% of GDP (2017). Historical examples of scientific and technological developments include the paddy cultivation technique terasering, which is common in Southeast Asia, and the pinisi boats by the Bugis and Makassar people. In the 1980s, Indonesian engineer Tjokorda Raka Sukawati invented a road construction technique named Sosrobahu that allows the construction of long stretches of flyovers above existing main roads with minimum traffic disruption. It later became widely used in several countries. The country is also an active producer of passenger trains and freight wagons with its state-owned company, the Indonesian Railway Industry (INKA), and has exported trains abroad.

Indonesia has a long history in developing military and small commuter aircraft as the only country in Southeast Asia to build and produce aircraft. With its state-owned company, the Indonesian Aerospace (PT. Dirgantara Indonesia), Indonesia has provided components for Boeing and Airbus. The company also collaborated with EADS CASA of Spain to develop the CN-235 that has seen use by several countries. Former President B. J. Habibie played a vital role in this achievement. Indonesia has also joined the South Korean programme to manufacture the fifth-generation jet fighter KAI KF-X.

Indonesia has a space programme and space agency, the National Institute of Aeronautics and Space (Lembaga Penerbangan dan Antariksa Nasional, LAPAN). In the 1970s, Indonesia became the first developing country to operate a satellite system called Palapa, a series of communication satellites owned by Indosat Ooredoo. The first satellite, PALAPA A1 was launched on 8 July 1976 from the Kennedy Space Center in Florida, United States. As of 2019, Indonesia has launched 18 satellites for various purposes, and LAPAN has expressed a desire to put satellites in orbit with native launch vehicles by 2040.

Tourism

Borobudur in Central Java, the world's largest Buddhist temple, is the single most visited tourist attraction in Indonesia.
 
Tourism contributed around US$19.7 billion to GDP in 2019. In 2018, Indonesia received 15.8 million visitors, a growth of 12.5% from last year, and received an average receipt of US$967. China, Singapore, Malaysia, Australia, and Japan are the top five sources of visitors to Indonesia. Since 2011, Wonderful Indonesia has been the slogan of the country's international marketing campaign to promote tourism.

Raja Ampat Islands, West Papua, has the highest recorded level of diversity in marine life according to Conservation International.
 
Nature and culture are prime attractions of Indonesian tourism. The former can boast a unique combination of a tropical climate, a vast archipelago, and a long stretch of beaches, and the latter complement those with a rich cultural heritage reflecting Indonesia's dynamic history and ethnic diversity. Indonesia has a well-preserved natural ecosystem with rain forests that stretch over about 57% of Indonesia's land (225 million acres). Forests on Sumatra and Kalimantan are examples of popular destinations, such as the Orangutan wildlife reserve. Moreover, Indonesia has one of the world's longest coastlines, measuring 54,716 kilometres (33,999 mi). The ancient Borobudur and Prambanan temples as well as Toraja and Bali, with its traditional festivities, are some of the popular destinations for cultural tourism.

Indonesia has nine UNESCO World Heritage Sites, including the Komodo National Park and the Sawahlunto Coal Mine; and a further 19 in a tentative list that includes Bunaken National Park and Raja Ampat Islands. Other attractions include the specific points in Indonesian history, such as the colonial heritage of the Dutch East Indies in the old towns of Jakarta and Semarang, and the royal palaces of Pagaruyung, Ubud, and Yogyakarta.

Demographics

Population pyramid 2016

The 2010 census recorded Indonesia's population as 237.6 million, the fourth largest in the world, with high population growth at 1.9%. Java is the world's most populous island, where 58% of the country's population lives. The population density is 138 people per km2 (357 per sq mi), ranking 88th in the world, although Java has a population density of 1,067 people per km2 (2,435 per sq mi). In 1961, the first post-colonial census recorded a total of 97 million people. It is expected to grow to around 295 million by 2030 and 321 million by 2050. The country currently possesses a relatively young population, with a median age of 30.2 years (2017 estimate).

The spread of the population is uneven throughout the archipelago with a varying habitat and level of development, ranging from the megacity of Jakarta to uncontacted tribes in Papua. As of 2010, about 49.7% of the population lives in urban areas. Jakarta is the country's primate city and the second-most populous urban area in the world with over 34 million residents. About 8 million Indonesians live overseas; most settled in Malaysia, the Netherlands, Saudi Arabia, the United Arab Emirates, Hong Kong, Singapore, the United States, and Australia.

Ethnic groups and languages

A map of ethnic groups in Indonesia

Indonesia is an ethnically diverse country, with around 300 distinct native ethnic groups. Most Indonesians are descended from Austronesian peoples whose languages had origins in Proto-Austronesian, which possibly originated in what is now Taiwan. Another major grouping is the Melanesians, who inhabit eastern Indonesia (the Maluku Islands and Western New Guinea).

The Javanese are the largest ethnic group, constituting 40.2% of the population, and are politically dominant. They are predominantly located in the central to eastern parts of Java and also sizable numbers in most provinces. The Sundanese, Malay, Batak, Madurese, Minangkabau and Buginese are the next largest groups in the country. A sense of Indonesian nationhood exists alongside strong regional identities.

The country's official language is Indonesian, a variant of Malay based on its prestige dialect, which for centuries had been the lingua franca of the archipelago. It was promoted by nationalists in the 1920s and achieved official status under the name Bahasa Indonesia in 1945. As a result of centuries-long contact with other languages, it is rich in local and foreign influences, including from Javanese, Sundanese, Minangkabau, Hindi, Sanskrit, Chinese, Arabic, Dutch, Portuguese and English. Nearly every Indonesian speaks the language due to its widespread use in education, academics, communications, business, politics, and mass media. Most Indonesians also speak at least one of more than 700 local languages, often as their first language. Most belong to the Austronesian language family, while there are over 270 Papuan languages spoken in eastern Indonesia. Of these, Javanese is the most widely spoken.

In 1930, Dutch and other Europeans (Totok), Eurasians, and derivative people like the Indos, numbered 240,000 or 0.4% of the total population. Historically, they constituted only a tiny fraction of the native population and continue to do so today. Despite the Dutch presence for almost 350 years, the Dutch language never had a substantial number of speakers or official status. The small minorities that can speak it or Dutch-based creole languages fluently are the aforementioned ethnic groups and descendants of Dutch colonisers. Today, there is some degree of fluency by either educated members of the oldest generation or legal professionals, as specific law codes are still only available in Dutch.

Religion

While the constitution stipulates religious freedom, the government officially recognises only six religions: Islam, Protestantism, Roman Catholicism, Hinduism, Buddhism, and Confucianism; with indigenous religions only partly acknowledged. Indonesia is the world's most populous Muslim-majority country with 227 million adherents in 2017, with the majority being Sunnis (99%). The Shias and Ahmadis respectively constitute 1% (1–3 million) and 0.2% (200,000–400,000) of the Muslim population. Almost 10% of Indonesians are Christians, while the rest are Hindus, Buddhists, and others. Most Hindus are Balinese, and most Buddhists are Chinese Indonesians.

 
The natives of the Indonesian archipelago originally practised indigenous animism and dynamism, beliefs that are common to Austronesian people. They worshipped and revered ancestral spirit, and believed that supernatural spirits (hyang) might inhabit certain places such as large trees, stones, forests, mountains, or sacred sites. Examples of Indonesian native belief systems include the Sundanese Sunda Wiwitan, Dayak's Kaharingan, and the Javanese Kejawèn. They have had a significant impact on how other faiths are practised, evidenced by a large proportion of people—such as the Javanese abangan, Balinese Hindus, and Dayak Christians—practising a less orthodox, syncretic form of their religion.

Hindu influences reached the archipelago as early as the first century CE. The Sundanese kingdom of Salakanagara in western Java around 130 was the first historically recorded Indianised kingdom in the archipelago. Buddhism arrived around the 6th century, and its history in Indonesia is closely related to that of Hinduism, as some empires based on Buddhism had its roots around the same period. The archipelago has witnessed the rise and fall of powerful and influential Hindu and Buddhist empires such as Majapahit, Sailendra, Srivijaya, and Mataram. Though no longer a majority, Hinduism and Buddhism remain defining influences in Indonesian culture.

Islam was introduced by Sunni traders of the Shafi'i fiqh, as well as Sufi traders from the Indian subcontinent and southern Arabian peninsula as early as the 8th century CE. For the most part, Islam overlaid and mixed with existing cultural and religious influences that resulted in a distinct form of Islam. Trade, missionary works such as by the Wali Sanga and Chinese explorer Zheng He, and military campaigns by several sultanates helped accelerate the spread of the religion. By the end of the 16th century, Islam had supplanted Hinduism and Buddhism as the dominant religion of Java and Sumatra. 

Catholicism was brought by Portuguese traders and missionaries such as Jesuit Francis Xavier, who visited and baptised several thousand locals. Its spread faced difficulty due to the VOC policy of banning the religion and the Dutch hostility due to the Eighty Years' War against Catholic Spain's rule. Protestantism is mostly a result of Calvinist and Lutheran missionary efforts during the Dutch colonial era. Although they are the most common branch, there is a multitude of other denominations elsewhere in the country.

There was a sizable Jewish presence in the archipelago until 1945, mostly Dutch and some Baghdadi Jews. Since most have left after Indonesia proclaimed independence, Judaism was never accorded official status, and only a tiny number of Jews remain today, mostly in Jakarta and Surabaya. At the national and local level, Indonesia's political leadership and civil society groups have played a crucial role in interfaith relations, both positively and negatively. The invocation of the first principle of Indonesia's philosophical foundation, Pancasila (the belief in the one and only God) often serves as a reminder of religious tolerance, though instances of intolerance have occurred. An overwhelming majority of Indonesians consider religion to be essential, and its role is present in almost all aspects of society, including politics, education, marriage, and public holidays.

Education and health


Education is compulsory for 12 years. Parents can choose between state-run, non-sectarian schools or private or semi-private religious (usually Islamic) schools, supervised by the ministries of Education and Religion, respectively. Private international schools that do not follow the national curriculum are also available. The enrolment rate is 90% for primary education, 76% for secondary education, and 24% for tertiary education (2015). The literacy rate is 95% (2016), and the government spends about 3.6% of GDP (2015) on education. In 2018, there were more than 4,500 higher educational institutions in Indonesia. The top universities are the Java-based University of Indonesia, Bandung Institute of Technology and Gadjah Mada University. Andalas University is pioneering the establishment of a leading university outside of Java.

Government expenditure on healthcare is about 3.3% of GDP in 2016. As part of an attempt to achieve universal health care, the government launched the National Health Insurance (Jaminan Kesehatan Nasional, JKN) in 2014 that provides health care to citizens. They include coverage for a range of services from the public and also private firms that have opted to join the scheme. In recent decades, there have been remarkable improvements such as rising life expectancy (from 63 in 1990 to 71 in 2012) and declining child mortality (from 84 deaths per 1,000 births in 1990 to 27 deaths in 2015). Nevertheless, Indonesia continues to face challenges that include maternal and child health, low air quality, malnutrition, high rate of smoking, and infectious diseases.

Issues

Nearly 80% of Indonesia's population lives in the western parts of the archipelago, but they are growing at a slower pace than the rest of the country. This situation creates a gap in wealth, unemployment rate, and health between densely populated islands and economic centres (such as Sumatra and Java) and sparsely populated, disadvantaged areas (such as Maluku and Papua).  Racism, especially against Chinese Indonesians since the colonial period, is still prevalent today. There has been a marked increase of religious intolerance since 1998, with the most recent high-profile case being that of Chinese Christian former governor of Jakarta, Basuki Tjahaja Purnama. LGBT issues have recently gained attention in Indonesia. While homosexuality is legal in most parts of the country, it is illegal in Aceh and South Sumatra. LGBT people and activists have regularly faced fierce opposition, intimidation, and discrimination launched even by authorities.

Culture

The cultural history of the Indonesian archipelago spans more than two millennia. Influences from the Indian subcontinent, mainland China, the Middle East, Europe, and the Austronesian peoples have historically shaped the cultural, linguistic and religious make-up of the archipelago. As a result, modern-day Indonesia has a multicultural, multilingual and multi-ethnic society, with a complex cultural mixture that differs significantly from the original indigenous cultures. Indonesia currently holds ten items of UNESCO's Intangible Cultural Heritage, including a wayang puppet theatre, kris, batik, pencak silat, angklung, and the three genres of traditional Balinese dance.

Art and architecture

Traditional Balinese painting depicting cockfighting

Indonesian arts include both age-old art forms developed through centuries and a recently developed contemporary art. Despite often displaying local ingenuity, Indonesian arts have absorbed foreign influences—most notably from India, the Arab world, China and Europe, as a result of contacts and interactions facilitated, and often motivated, by trade. Painting is an established and developed art in Bali, where its people are famed for their artistry. Their painting tradition started as classical Kamasan or Wayang style visual narrative, derived from visual art discovered on candi bas reliefs in eastern Java.

An avenue of Tongkonan houses in a Torajan village, South Sulawesi

There have been numerous discoveries of megalithic sculptures in Indonesia. Subsequently, tribal art has flourished within the culture of Nias, Batak, Asmat, Dayak and Toraja. Wood and stone are common materials used as the media for sculpting among these tribes. Between the 8th and 15th centuries, the Javanese civilisation has developed a refined stone sculpting art and architecture which was influenced by Hindu-Buddhist Dharmic civilisation. The temples of Borobudur and Prambanan are among the most famous examples of the practice.

As with the arts, Indonesian architecture has absorbed foreign influences that have brought cultural changes and profound effect on building styles and techniques. The most dominant has traditionally been Indian; however, Chinese, Arab, and European influences have also been significant. Traditional carpentry, masonry, stone and woodwork techniques and decorations have thrived in vernacular architecture, with numbers of traditional houses' (rumah adat) styles that have been developed. The traditional houses and settlements in the country vary by ethnic groups, and each has a specific custom and history. Examples include Toraja's Tongkonan, Minangkabau's Rumah Gadang and Rangkiang, Javanese style Pendopo pavilion with Joglo style roof, Dayak's longhouses, various Malay houses, Balinese houses and temples, and also different forms of rice barns (lumbung).

Music, dance and clothing

Indonesian music and dance. Clockwise from top: A gamelan player, Angklung, Sundanese Jaipongan Mojang Priangan dance, Balinese Pendet dance.
 
The music of Indonesia predates historical records. Various indigenous tribes incorporate chants and songs accompanied by musical instruments in their rituals. Angklung, kacapi suling, siteran, gong, gamelan, degung, gong kebyar, bumbung, talempong, kulintang, and sasando are examples of traditional Indonesian instruments. The diverse world of Indonesian music genres is the result of the musical creativity of its people, and subsequent cultural encounters with foreign influences. These include gambus and qasida from the Middle East, keroncong from Portugal, and dangdut—one of the most popular music genres in Indonesia—with notable Hindi influence as well as Malay orchestras. Today, the Indonesian music industry enjoys both nationwide and regional popularity in Malaysia, Singapore, and Brunei, due to common culture and intelligible languages between Indonesian and Malay.

An Indonesian batik

Indonesian dances have a diverse history, with more than 3,000 original dances. Scholars believe that they had their beginning in rituals and religious worship. Examples include war dances, a dance of witch doctors, and dance to call for rain or any agricultural rituals such as Hudoq. Indonesian dances derive its influences from the archipelago's three distinct historical eras: the prehistoric and tribal, the Hindu-Buddhist, and the Islamic. Recently, show businesses, such as those that accompany music performances or entertainment begin showcasing modern dances. Influenced by Western culture, urban teen dances such as street dances have gained popularity among the Indonesian youth. Traditional dances, however, such as the Javanese, Sundanese, Minang, Balinese, Saman continue to be a living and dynamic tradition.

Indonesia has various styles of clothing as a result of its long and rich cultural history. The national costume has its origins in the indigenous culture of the country and traditional textile traditions. Since Java is the political, economic and cultural centre of Indonesia, the Javanese Batik and Kebaya are arguably Indonesia's most recognised national costume. They originally belong not only to the Javanese but also to Sundanese and Balinese cultures as well. Each province has a representation of traditional attire and dress, such as Ulos of Batak from North Sumatra; Songket of Malay and Minangkabau from Sumatra; and Ikat of Sasak from Lombok. People wear national and regional costumes during traditional weddings, formal ceremonies, music performances, government and official occasions, and they vary from traditional to modern attire. In 2009, Batik was recognised by UNESCO as a Masterpiece of Oral and Intangible Heritage of Humanity.

Theatre and cinema

Pandava and Krishna in an act of the Wayang Wong performance

Wayang, the Javanese, Sundanese, and Balinese shadow puppet theatre display several mythological legends such as Ramayana and Mahabharata. Other forms of local drama include the Javanese Ludruk and Ketoprak, the Sundanese Sandiwara, Betawi Lenong, and various Balinese dance drama. They incorporate humour and jest and often involve audiences in their performances. Some theatre traditions also include music, dancing and the silat martial art such as Randai from Minangkabau people of West Sumatra. It is usually performed for traditional ceremonies and festivals, and based on semi-historical Minangkabau legends and love story. Modern performing art also developed in Indonesia with their distinct style of drama. Notable theatre, dance, and drama troupe such as Teater Koma are famous as it often portrays social and political satire of Indonesian society.

Advertisement for Loetoeng Kasaroeng (1926), the first fiction film produced in the Dutch East Indies

The first film produced in the archipelago was Loetoeng Kasaroeng, a silent film by Dutch director L. Heuveldorp. The film industry expanded after independence, with six films made in 1949 rising to 58 in 1955. Usmar Ismail, who made significant imprints in the 1950s and 1960s, is generally considered to be the pioneer of Indonesian films. The latter part of the Sukarno era saw the use of cinema for nationalistic, anti-Western purposes, and foreign films were subsequently banned, while the New Order utilised a censorship code that aimed to maintain social order. Production of films peaked during the 1980s, although it declined significantly in the next decade. Notable films in this period include Pengabdi Setan (1980), Nagabonar (1987), Tjoet Nja' Dhien (1988), Catatan Si Boy (1989), and Warkop's comedy films.

Independent filmmaking was a rebirth of the film industry since 1998, where films started addressing previously banned topics, such as religion, race, and love. Between 2000 and 2005, the number of films released each year steadily increased. Riri Riza and Mira Lesmana were among the new generation of filmmakers who co-directed Kuldesak (1999), Petualangan Sherina (2000), Ada Apa dengan Cinta? (2002), and Laskar Pelangi (2008). In 2016, Warkop DKI Reborn: Jangkrik Boss Part 1 smashed box office records, becoming the most-watched Indonesian film with 6.8 million tickets sold. Indonesia has held annual film festivals and awards, including the Indonesian Film Festival (Festival Film Indonesia) that has been held intermittently since 1955. It hands out the Citra Award, the film industry's most prestigious award. From 1973 to 1992, the festival was held annually and then discontinued until its revival in 2004.

Media and literature


Media freedom increased considerably after the fall of the New Order, during which the Ministry of Information monitored and controlled domestic media and restricted foreign media. The television market includes several national commercial networks and provincial networks that compete with public TVRI, which held a monopoly on TV broadcasting from 1962 to 1989. By the early 21st century, the improved communications system had brought television signals to every village and people can choose from up to 11 channels. Private radio stations carry news bulletins while foreign broadcasters supply programmes. The number of printed publications has increased significantly since 1998. More than 30 million cell phones are sold each year, with 27% of them being local brands.

Like other developing countries, Indonesia began development of the Internet in the early 1990s. Its first commercial Internet service provider, PT. Indo Internet began operation in Jakarta in 1994. The country had 171 million Internet users in 2018, with a penetration rate that keeps increasing annually. Most are between the ages of 15 and 19 and depend primarily on mobile phones for access, outnumbering both laptops and computers.


The oldest evidence of writing in the Indonesian archipelago is a series of Sanskrit inscriptions dated to the 5th century. Many of Indonesia's peoples have firmly rooted oral traditions, which help to define and preserve their cultural identities. In written poetry and prose, several traditional forms dominate, mainly syair, pantun, gurindam, hikayat and babad. Some of these works are Syair Raja Siak, Syair Abdul Muluk, Hikayat Abdullah, Hikayat Bayan Budiman, Hikayat Hang Tuah, Sulalatus Salatin, and Babad Tanah Jawi.

Early modern Indonesian literature originates in Sumatran tradition. Balai Pustaka, the government bureau for popular literature, was instituted around 1920 to promote the development of indigenous literature. It adopted Malay as the preferred universal medium. Prominent figures in modern Indonesian literature include Dutch author Multatuli, who criticised the treatment of natives under Dutch colonial rule; Sumatrans Mohammad Yamin and Hamka, who were influential pre-independence nationalist writers and politicians; and proletarian writer Pramoedya Ananta Toer, Indonesia's most famous novelist. Pramoedya earned several accolades, and many considered him to be Southeast Asia's leading candidate for a Nobel Prize in Literature. Literature and poetry flourished even more in the first half of the 20th century. Notable authors include Chairil Anwar (Aku), Marah Roesli (Sitti Nurbaya), Merari Siregar (Azab dan Sengsara), Abdul Muis (Salah Asuhan), Djamaluddin Adinegoro (Darah Muda), Sutan Takdir Alisjahbana (Layar Terkembang), and Amir Hamzah (Nyanyi Sunyi) whose works are among the most well known in Maritime Southeast Asia.

Cuisine

Nasi Padang with rendang, gulai and vegetables

Indonesian cuisine is one of the most diverse, vibrant, and colourful in the world, full of intense flavour. Many regional cuisines exist, often based upon indigenous culture and foreign influences such as Chinese, European, Middle Eastern, and Indian precedents. Rice is the leading staple food and is served with side dishes of meat and vegetables. Spices (notably chilli), coconut milk, fish and chicken are fundamental ingredients.

Some popular dishes such as nasi goreng, gado-gado, sate, and soto are prevalent and considered as national dishes. The Ministry of Tourism, however, chose tumpeng as the official national dish in 2014, describing it as binding the diversity of various culinary traditions. Other popular dishes include rendang, one of the many Padang cuisines along with dendeng and gulai. In 2017, rendang was chosen as the "World's Most Delicious Food" by the CNN Travel reader's choice. Another fermented food is oncom, similar in some ways to tempeh but uses a variety of bases (not only soy), created by different fungi, and particularly popular in West Java.

Sports

A demonstration of Pencak Silat, a form of martial arts

Sports are generally male-oriented, and spectators are often associated with illegal gambling. Badminton and football are the most popular sports. Indonesia is among the only five countries that have won the Thomas and Uber Cup, the world team championship of men's and women's badminton. Along with weightlifting, it is the sport that contributes the most to Indonesia's Olympic medal tally. Liga 1 is the country's premier football club league. On the international stage, Indonesia has experienced limited success despite being the first Asian team to participate in the FIFA World Cup in 1938 as Dutch East Indies. On the continental level, Indonesia won the bronze medal in the 1958 Asian Games. Indonesia's first appearance in the AFC Asian Cup was in 1996 and successfully qualified for the next three tournaments. They, however, failed to progress through the next stage in all occasions.

Other popular sports include boxing and basketball, which has a long history in Indonesia and was part of the first National Games (Pekan Olahraga Nasional, PON) in 1948. Some of the famous Indonesian boxers include Ellyas Pical, three times IBF Super flyweight champion; Nico Thomas, Muhammad Rachman, and Chris John. In motorsport, Rio Haryanto became the first Indonesian to compete in Formula One in 2016. Sepak takraw and karapan sapi (bull racing) in Madura are some examples of traditional sports in Indonesia. In areas with a history of tribal warfare, mock fighting contests are held, such as caci in Flores and pasola in Sumba. Pencak Silat is an Indonesian martial art and in 1987, became one of the sporting events in the Southeast Asian Games, with Indonesia appearing as one of the leading competitors. In Southeast Asia, Indonesia is one of the top sports powerhouses by winning the Southeast Asian Games ten times since 1977, most recently in 2011.

Streptococcus pyogenes

From Wikipedia, the free encyclopedia
 
Streptococcus pyogenes
"S. pyogenes" bacteria at 900× magnification
S. pyogenes bacteria at 900× magnification
Scientific classification 
Domain: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Streptococcaceae
Genus: Streptococcus
Species:
S. pyogenes
Binomial name
Streptococcus pyogenes
Rosenbach 1884

Streptococcus pyogenes is a species of Gram-positive, aerotolerant bacterium in the genus Streptococcus. These bacteria are extracellular, and made up of non-motile and non-sporing cocci. It is clinically important for humans. It is an infrequent, but usually pathogenic, part of the skin microbiota. It is the predominant species harboring the Lancefield group A antigen, and is often called group A Streptococcus (GAS). However, both Streptococcus dysgalactiae and the Streptococcus anginosus group can possess group A antigen. Group A streptococci when grown on blood agar typically produces small zones of beta-hemolysis, a complete destruction of red blood cells. (A zone size of 2–3 mm is typical.) It is thus also called group A (beta-hemolytic) Streptococcus (GABHS), and it can make colonies greater than 5 mm in size.

Like other cocci, streptococci are round bacteria. The species name is derived from Greek words meaning 'a chain' (streptos) of berries (coccus [Latinized from kokkos]) and pus (pyo)-forming(genes), because streptococcal cells tend to link in chains of round cells (see image) and a number of infections caused by the bacterium produce pus. The main criterion for differentiation between Staphylococcus spp. and Streptococcus spp. is the catalase test. Staphylococci are catalase positive whereas streptococci are catalase-negative. S. pyogenes can be cultured on fresh blood agar plates. Under ideal conditions, it has an incubation period of 1 to 3 days.

An estimated 700 million GAS infections occur worldwide each year. While the overall mortality rate for these infections is 0.1%, over 650,000 of the cases are severe and invasive, and have a mortality rate of 25%. Early recognition and treatment are critical; diagnostic failure can result in sepsis and death.

Epidemiology

S. pyogenes typically colonizes the throat, genital mucosa, rectum, and skin. Of healthy individuals, 1% to 5% have throat, vaginal, or rectal carriage. In healthy children, such carriage rate varies from 2% to 17%. There are four methods for the transmission of this bacterium: inhalation of respiratory droplets, skin contact, contact with objects, surface, or dust that is contaminated with bacteria or, less commonly, transmission through food. Such bacteria can cause a variety of diseases such as streptococcal pharyngitis, rheumatic fever, rheumatic heart disease, and scarlet fever. Although pharyngitis is mostly viral in origin, about 15 to 30% of all pharyngitis cases in children are caused by GAS; meanwhile, 5 to 20% of pharyngitis in adults are streptococcal. The number of pharyngitis cases is higher in children when compared with adults due to exposures in schools, nurseries, and as a consequence of lower host immunity. Such cases Streptococcal pharyngitis occurs more frequently from December to April (later winter to early spring) in seasonal countries, possibly due to changing climate, behavioural changes or predisposing viral infection. Disease cases are the lowest during autumn.

MT1 (metabolic type 1) clone is frequently associated with invasive Streptococcus pyogenes infections among developed countries. The incidence and mortality of S. pyogenes was high during the pre-penicillin era, but had already started to fall prior to the widespread availability of penicillin. Therefore, environmental factors do play a role in the S. pyogenes infection. Incidence of S. pyogenes is 2 to 4 per 100,000 population in developed countries and 12 to 83 per 100,000 population in developing countries. S. pyogenes infection is more frequently found in men than women, with highest rates in the elderly, followed by infants. In people with risk factors such as heart disease, diabetes, malignancy, blunt trauma, surgical incision, virus respiratory infection, including influenza, S. pyogenes infection happens in 17 to 25% of all cases. GAS secondary infection usually happens within one week of the diagnosis of influenza infection. In 14 to 16% of childhood S. pyogenes infections, there is a prior chickenpox infection. Such S. pyogenes infection in children usually manifests as severe soft tissue infection with onset 4 to 12 days from the chickenpox diagnosis. There is also 40 to 60 times increase in risk of S. pyogenes infection within the first two weeks of chickenpox infection in children. However, 20 to 30% of S. pyogenes infection does occur in adults with no identifiable risk factors. The incidence is higher in children (50 to 80% of S. pyogenes infection) with no known risk factors. The rates of scarlet fever in UK was usually 4 in 100,000 population, however, in 2014, the rates had risen to 49 per 100,000 population. Rheumatic fever and rheumatic heart disease (RHD) usually occurs at 2 to 3 weeks after the throat infection, which is more common among the impoverished people in developing countries. From 1967 to 1996, the global mean incidence of rheumatic fever and RHD was 19 per 100,000 with the highest incidence at 51 per 100,000.

Maternal S. pyogenes infection usually happens in late pregnancy; at more than 30 weeks of gestation to four weeks postpartum, which accounts for 2 to 4% of all the S. pyogenes infections. This represents 20 to 100 times increase in risk for S. pyogenes infections. Clinical manifestations are: pneumonia, septic arthritis, necrotizing fasciitis, and genital tract sepsis. According to a study done by Queen Charlotte's hospital in London during the 1930's, the vagina was not the common source of such infection. On the contrary, maternal throat infection and close contacts with carriers were the more common sites for maternal S. pyogenes infection.

Bacteriology

Serotyping

In 1928, Rebecca Lancefield published a method for serotyping S. pyogenes based on its cell-wall polysaccharide, a virulence factor displayed on its surface. Later, in 1946, Lancefield described the serologic classification of S. pyogenes isolates based on their surface T-antigen. Four of the 20 T-antigens have been revealed to be pili, which are used by bacteria to attach to host cells. As of 2016, a total of 120 M proteins are identified. These M proteins are encoded by 234 types emm gene with greater than 1,200 alleles.

Lysogeny

All strains of S. pyogenes are polylysogenized, in that they carry one or more bacteriophage on their genomes. Some of the 'phages may be defective, but in some cases active 'phage may compensate for defects in others. In general, the genome of S. pyogenes strains isolated during disease are >90% identical, they differ by the 'phage they carry.

Virulence factors

S. pyogenes has several virulence factors that enable it to attach to host tissues, evade the immune response, and spread by penetrating host tissue layers. A carbohydrate-based bacterial capsule composed of hyaluronic acid surrounds the bacterium, protecting it from phagocytosis by neutrophils. In addition, the capsule and several factors embedded in the cell wall, including M protein, lipoteichoic acid, and protein F (SfbI) facilitate attachment to various host cells. M protein also inhibits opsonization by the alternative complement pathway by binding to host complement regulators. The M protein found on some serotypes is also able to prevent opsonization by binding to fibrinogen. However, the M protein is also the weakest point in this pathogen's defense, as antibodies produced by the immune system against M protein target the bacteria for engulfment by phagocytes. M proteins are unique to each strain, and identification can be used clinically to confirm the strain causing an infection.

Name Description
Streptolysin O An exotoxin, one of the bases of the organism's beta-hemolytic property, streptolysin O causes an immune response and detection of antibodies to it; antistreptolysin O (ASO) can be clinically used to confirm a recent infection. It is damaged by oxygen.
Streptolysin S A cardiotoxic exotoxin, another beta-hemolytic component, not immunogenic and O2 stable: A potent cell poison affecting many types of cell including neutrophils, platelets, and subcellular organelles.
Streptococcal pyrogenic exotoxin A (SpeA) Superantigens secreted by many strains of S. pyogenes: This pyrogenic exotoxin is responsible for the rash of scarlet fever and many of the symptoms of streptococcal toxic shock syndrome, also known as toxic shock like syndrome(TSLS).
Streptococcal pyrogenic exotoxin C (SpeC)
Streptococcal pyrogenic exotoxin B (SpeB) A cysteine protease and the predominant secreted protein. Multiple actions, including degrading the extracellular matrix, cytokines, complement components, and immunoglobulins. Also called streptopain.
Streptokinase Enzymatically activates plasminogen, a proteolytic enzyme, into plasmin, which in turn digests fibrin and other proteins
Hyaluronidase Hyaluronidase is widely assumed to facilitate the spread of the bacteria through tissues by breaking down hyaluronic acid, an important component of connective tissue. However, very few isolates of S. pyogenes are capable of secreting active hyaluronidase due to mutations in the gene that encodes the enzyme. Moreover, the few isolates capable of secreting hyaluronidase do not appear to need it to spread through tissues or to cause skin lesions. Thus, the true role of hyaluronidase in pathogenesis, if any, remains unknown.
Streptodornase Most strains of S. pyogenes secrete up to four different DNases, which are sometimes called streptodornase. The DNases protect the bacteria from being trapped in neutrophil extracellular traps (NETs) by digesting the NETs' web of DNA, to which are bound neutrophil serine proteases that can kill the bacteria.
C5a peptidase C5a peptidase cleaves a potent neutrophil chemotaxin called C5a, which is produced by the complement system. C5a peptidase is necessary to minimize the influx of neutrophils early in infection as the bacteria are attempting to colonize the host's tissue. C5a peptidase, although required to degrade the neutrophil chemotaxin C5a in the early stages of infection, is not required for S. pyogenes to prevent the influx of neutrophils as the bacteria spread through the fascia.
Streptococcal chemokine protease The affected tissue of patients with severe cases of necrotizing fasciitis are devoid of neutrophils. The serine protease ScpC, which is released by S. pyogenes, is responsible for preventing the migration of neutrophils to the spreading infection. ScpC degrades the chemokine IL-8, which would otherwise attract neutrophils to the site of infection.

Genome

The genomes of different strains were sequenced (genome size is 1.8–1.9 Mbp) encoding about 1700-1900 proteins (1700 in strain NZ131, 1865 in strain MGAS5005). Complete genome sequences of the type strain of S. pyogenes (NCTC 8198T = CCUG 4207T) are available in DNA Data Bank of Japan, European Nucleotide Archive, and GenBank under the accession numbers LN831034 and CP028841.

Biofilm formation

Biofilms are a way for S. pyogenes, as well as other bacterial cells, to communicate with each other. In the biofilm gene expression for multiple purposes (such as defending against the host immune system) is controlled via quorum sensing. One of the biofilm forming pathways in GAS is the Rgg2/3 pathway. It regulates SHP's (short hydrophobic peptides) that are quorum sensing pheromones a.k.a. autoinducers. The SHP's are translated to an immature form of the pheromone and must undergo processing, first by a metalloprotease enzyme inside the cell and then in the extracellular space, to reach their mature active form. The mode of transportation out of the cell and the extracellular processing factor(s) are still unknown. The mature SHP pheromone can then be taken into nearby cells and the cell it originated from via a transmembrane protein, oligopeptide permease. In the cytosol the pheromones have two functions in the Rgg2/3 pathway. Firstly, they inhibit the activity of Rgg3 which is a transcriptional regulator repressing SHP production. Secondly, they bind another transcriptional regulator, Rgg2, that increases the production of SHP's, having an antagonistic effect to Rgg3. SHP's activating their own transcriptional activator creates a positive feedback loop, which is common for the production for quorum sensing peptides. It enables the rapid production of the pheromones in large quantities. The production of SHP's increases biofilm biogenesis. It has been suggested that GAS switches between biofilm formation and degradation by utilizing pathways with opposing effects. Whilst Rgg2/3 pathway increases biofilm, the RopB pathway disrupts it. RopB is another Rgg-like protein (Rgg1) that directly activates SpeB (Streptococcal pyrogenic exotoxin B), a cysteine protease that acts as a virulence factor. In the absence of this pathway, biofilm formation is enhanced, possibly due to the lack of the protease degrading pheromones or other Rgg2/3 pathway counteracting effects.

Disease

S. pyogenes is the cause of many human diseases, ranging from mild superficial skin infections to life-threatening systemic diseases. Infections typically begin in the throat or skin. The most striking sign is a strawberry-like rash. Examples of mild S. pyogenes infections include pharyngitis (strep throat) and localized skin infection (impetigo). Erysipelas and cellulitis are characterized by multiplication and lateral spread of S. pyogenes in deep layers of the skin. S. pyogenes invasion and multiplication in the fascia can lead to necrotizing fasciitis, a life-threatening condition requiring surgery.  The bacterium is found in neonatal infections.

Infections due to certain strains of S. pyogenes can be associated with the release of bacterial toxins. Throat infections associated with release of certain toxins lead to scarlet fever. Other toxigenic S. pyogenes infections may lead to streptococcal toxic shock syndrome, which can be life-threatening.

S. pyogenes can also cause disease in the form of post-infectious "non-pyogenic" (not associated with local bacterial multiplication and pus formation) syndromes. These autoimmune-mediated complications follow a small percentage of infections and include rheumatic fever and acute post-infectious glomerulonephritis. Both conditions appear several weeks following the initial streptococcal infection. Rheumatic fever is characterized by inflammation of the joints and/or heart following an episode of streptococcal pharyngitis. Acute glomerulonephritis, inflammation of the renal glomerulus, can follow streptococcal pharyngitis or skin infection.

This bacterium remains acutely sensitive to penicillin. Failure of treatment with penicillin is generally attributed to other local commensal organisms producing β-lactamase, or failure to achieve adequate tissue levels in the pharynx. Certain strains have developed resistance to macrolides, tetracyclines, and clindamycin.

Applications

Bionanotechnology

Many S. pyogenes proteins have unique properties, which have been harnessed in recent years to produce a highly specific "superglue" and a route to enhance the effectiveness of antibody therapy.

Genome editing

The CRISPR system from this organism  that is used to recognize and destroy DNA from invading viruses, thus stopping the infection, was appropriated in 2012 for use as a genome-editing tool that could potentially alter any piece of DNA and later RNA.

Microcephaly

From Wikipedia, the free encyclopedia

Microcephaly
Microcephaly-comparison-500px.jpg
A baby with microcephaly (left) compared to a baby with a typical head size
SpecialtyMedical genetics, Psychiatry, Neurology
PrognosisPoor
A mother holding her son that was born with microcephaly due to vertically transmitted infection with Zika virus
 
Microcephaly is a medical condition in which the brain does not develop properly, resulting in a shorter-than-normal head. Microcephaly may be present at birth or it may develop in the first few years of life. Often, people with this disorder have an intellectual disability, poor motor function, poor speech, abnormal facial features, seizures and dwarfism.

The disorder is caused by a disruption to the genetic processes that form the brain early in pregnancy, though the cause is not identified in most cases. Many genetic syndromes can result in microcephaly, including chromosomal and single-gene conditions, though almost always in combination with other symptoms. Mutations that result solely in microcephaly (primary microcephaly) exist but are less common. External toxins to the embryo, such as alcohol during pregnancy or vertically transmitted infections, can also result in microcephaly. Microcephaly serves as an important neurological indication or warning sign, but no uniformity exists in its definition. It is usually defined as a head circumference (HC) more than two standard deviations below the mean for age and sex. Some academics advocate defining it as head circumference more than three standard deviations below the mean for the age and sex.

There is no specific treatment that returns the head size to normal. In general, life expectancy for individuals with microcephaly is reduced, and the prognosis for normal brain function is poor. Occasional cases develop normal intelligence and grow normally (apart from persistently small head circumference). It is reported that in the United States, microcephaly occurs in 2 to 12 babies per 10,000 births.

Signs and symptoms

There are a variety of symptoms that can occur in children. Infants with microcephaly are born with either a normal or reduced head size. Subsequently, the head fails to grow, while the face continues to develop at a normal rate, producing a child with a small head and a receding forehead, and a loose, often wrinkled scalp. As the child grows older, the smallness of the skull becomes more obvious, although the entire body also is often underweight and dwarfed.

Severely impaired intellectual development is common, but disturbances in motor functions may not appear until later in life. Affected newborns generally have striking neurological defects and seizures. Development of motor functions and speech may be delayed. Hyperactivity and intellectual disability are common occurrences, although the degree of each varies. Convulsions may also occur. Motor ability varies, ranging from clumsiness in some to spastic quadriplegia in others.

Causes

Neural scans of a normal-sized skull (left) and a case of microcephaly (right)

Microcephaly is a type of cephalic disorder. It has been classified in two types based on the onset:

Congenital

Postnatal onset

Genetic mutations cause most cases of microcephaly. Relationships have been found between autism, duplications of genes and macrocephaly on one side. On the other side, a relationship has been found between schizophrenia, deletions of genes and microcephaly. Several genes have been designated "MCPH" genes, after microcephalin (MCPH1), based on their role in brain size and primary microcephaly syndromes when mutated. In addition to microcephalin, these include WDR62 (MCPH2), CDK5RAP2 (MCPH3), KNL1 (MCPH4), ASPM (MCPH5), CENPJ (MCPH6), STIL (MCPH7), CEP135 (MCPH8), CEP152 (MCPH9), ZNF335 (MCPH10), PHC1 (MCPH11) and CDK6 (MCPH12). Moreover, an association has been established between common genetic variants within known microcephaly genes (such as MCPH1 and CDK5RAP2) and normal variation in brain structure as measured with magnetic resonance imaging (MRI)‍—‌i.e., primarily brain cortical surface area and total brain volume.

The spread of Aedes mosquito-borne Zika virus has been implicated in increasing levels of congenital microcephaly by the International Society for Infectious Diseases and the US Centers for Disease Control and Prevention. Zika can spread from a pregnant woman to her fetus. This can result in other severe brain malformations and birth defects. A study published in The New England Journal of Medicine has documented a case in which they found evidence of the Zika virus in the brain of a fetus that displayed the morphology of microcephaly.

Microcephaly

"Microcephaly" means "smallheadedness" (New Latin microcephalia, from Ancient Greek μικρός mikrós "small" and κεφαλή kephalé "head"). However, the older, slightly more traditional classification, "microcephaly", translates to, "smallness of brain". Similar to various sociocultural updates in linguistics, the term is deemed obsolete by modern medical culture. Therefore, because the size of the brain is most often determined by the size of one's skull, the use of classifying, "microcephaly", in more modern literature, is today almost always implied when discussing cases wherein microcephaly manifests.

Microlissencephaly

Microlissencephaly is microcephaly combined with lissencephaly (smooth brain surface due to absent sulci and gyri). Most cases of microlissencephaly are described in consanguineous families, suggesting an autosomal recessive inheritance.

Historical causes of microcephaly

After the dropping of atomic bombs "Little Boy" on Hiroshima and "Fat Man" on Nagasaki, several women close to ground zero who had been pregnant at the time gave birth to children with microcephaly. Microcephaly was present in 7 children from a group of 11 pregnant women at 11–17 weeks of gestation who survived the blast at less than 1.2 km (0.75 mi) from ground zero. Due to their proximity to the bomb, the pregnant women's in utero children received a biologically significant radiation dose that was relatively high due to the massive neutron output of the lower explosive-yielding Little Boy. Researchers studied 286 additional children who were in utero during the atomic bombings, and after a year they found these children had a higher incidence of microcephaly and mental retardation.

Other relations

Intracranial volume also affects this pathology, as it is related with the size of the brain.

Pathophysiology

Microcephaly generally is due to the diminished size of the largest part of the human brain, the cerebral cortex, and the condition can arise during embryonic and fetal development due to insufficient neural stem cell proliferation, impaired or premature neurogenesis, the death of neural stem cells or neurons, or a combination of these factors. Research in animal models such as rodents has found many genes that are required for normal brain growth. For example, the Notch pathway genes regulate the balance between stem cell proliferation and neurogenesis in the stem cell layer known as the ventricular zone, and experimental mutations of many genes can cause microcephaly in mice, similar to human microcephaly. Mutations of the abnormal spindle-like microcephaly-associated (ASPM) gene are associated with microcephaly in humans and a knockout model has been developed in ferrets that exhibits severe microcephaly. In addition, viruses such as cytomegalovirus (CMV) or Zika have been shown to infect and kill the primary stem cell of the brain—the radial glial cell, resulting in the loss of future daughter neurons. The severity of the condition may depend on the timing of infection during pregnancy. 

Microcephaly is a feature common to several different genetic disorders arising from a deficiency in the cellular DNA damage response. Individuals with the following DNA damage response disorders exhibit microcephaly: Nijmegen breakage syndrome, ATR-Seckel syndrome, MCPH1-dependent primary microcephaly disorder, xeroderma pigmentosum complementation group A deficiency, Fanconi anemia, ligase 4 deficiency syndrome and Bloom syndrome. These findings suggest that a normal DNA damage response is critical during brain development, perhaps to protect against induction of apoptosis by DNA damage occurring in neurons.

Treatment

Baby with microcephaly during a physical therapy session

There is no known cure for microcephaly. Treatment is symptomatic and supportive. Because some cases of microcephaly and its associated symptoms may be a result of amino acid deficiencies, treatment with amino acids in these cases has been shown to improve symptoms such as seizures and motor function delays.

History

People with microcephaly were sometimes sold to freak shows in North America and Europe in the 19th and early 20th centuries, where they were known by the name "pinheads". Many of them were presented as different species (e.g., "monkey man") and described as being the missing link. Famous examples include Zip the Pinhead (although he may not have had microcephaly) and Schlitzie the Pinhead, who also starred in the 1932 film Freaks. Both men were cited as influences on the development of the long-running comic strip character Zippy the Pinhead, created by Bill Griffith.

Notable cases

  • A certain 'dwarf' of Punt (ancient Somalia) was given by the Chief clans as partial tribute to the last ruler of Ancient Egypt's Old Kingdom, Pepi II Neferkare (6th Dynasty, circa 2125–2080 B.C.E.); it could be inferred that this person was indeed, also microcephalic. In a letter preserved at the British Museum, the young king gives instructions by letter, "Harkhuf! The men in your service [escorts; soldiers; sailors; guards, etc.] ought pay sincere care with the dwarf's head while sleeping during the voyage to the palace" (so that it does not fall off). At the same time, it could be for other reasons unrelated to microcephaly, etc.
  • Triboulet, a jester of duke René of Anjou (not to be confused with the slightly later Triboulet at the French court).
  • Jenny Lee Snow and Elvira Snow, whose stage names were Pip and Zip, respectively, were sisters with microcephaly who acted in the 1932 film Freaks.
  • Schlitze "Schlitzie" Surtees, possibly born Simon Metz, was a sideshow performer and actor.
  • Lester "Beetlejuice" Green, a member of radio host Howard Stern's Wack Pack.

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