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Wednesday, September 15, 2021

Dream

From Wikipedia, the free encyclopedia

Self-Portrait of a Dreamer, Joseph Klibansky, 2016, Museumplein, Amsterdam.

A dream is a succession of images, ideas, emotions, and sensations that usually occur involuntarily in the mind during certain stages of sleep. During a typical lifespan, a person spends a total of about six years dreaming (which is about two hours each night). Most dreams last only 5 to 20 minutes.

The content and function of dreams have been a topic of scientific, philosophical and religious interest throughout recorded history. Dream interpretation, practiced by the Babylonians in the third millennium BCE and even earlier by the ancient Sumerians, figures prominently in religious texts in several traditions and has played a lead role in psychotherapy. The scientific study of dreams is called oneirology. Most modern dream study focuses on the neurophysiology of dreams and on proposing and testing hypotheses regarding dream function. It is not known where in the brain dreams originate, if there is a single origin for dreams or if multiple regions of the brain are involved, or what the purpose of dreaming is for the body or mind.

The human dream experience and what to make of it have undergone sizable shifts over the course of history. Long ago, according to writings from Mesopotamia and Ancient Egypt, dreams dictated post-dream behaviors to an extent sharply reduced in later millennia. These ancient writings about dreams highlight visitation dreams, where a dream figure, usually a deity or a prominent forebear, commands the dreamer to take specific actions and may predict future events. The brain activity capable of formulating such dreams, rare among literate people in later eras, conforms to the bicameral mentality hypothesized by Julian Jaynes as dominant into the second or first millennium BCE. Framing the dream experience varies across cultures as well as through time.

Dreaming and sleep are intertwined. Dreams occur mainly in the rapid-eye movement (REM) stage of sleep—when brain activity is high and resembles that of being awake. Because REM sleep is detectable in many species, and because research suggests that all mammals experience REM, linking dreams to REM sleep has led to conjectures that animals dream. However, humans dream during non-REM sleep, also, and not all REM awakenings elicit dream reports. To be studied, a dream must first be reduced to a verbal report, which is an account of the subject's memory of the dream, not the subject's dream experience itself. So, dreaming by non-humans is currently unprovable, as is dreaming by human fetuses and pre-verbal infants.

Subjective experience

Usha Dreaming Aniruddha (oleographic print) Raja Ravi Varma (1848-1906).

Preserved writings from early Mediterranean civilizations indicate a relatively abrupt change in subjective dream experience between Bronze Age antiquity and the beginnings of the classical era.

In visitation dreams reported in ancient writings, dreamers were largely passive in their dreams, and visual content served primarily to frame authoritative auditory messaging. Gudea, the king of the Sumerian city-state of Lagash (reigned c. 2144–2124 BCE), rebuilt the temple of Ningirsu as the result of a dream in which he was told to do so. After antiquity, the passive hearing of visitation dreams largely gave way to visualized narratives in which the dreamer becomes a character who actively participates.

From the 1940s to 1985, Calvin S. Hall collected more than 50,000 dream reports at Western Reserve University. In 1966 Hall and Robert Van de Castle published The Content Analysis of Dreams, in which they outlined a coding system to study 1,000 dream reports from college students. Results indicated that participants from varying parts of the world demonstrated similarity in their dream content. The only residue of antiquity's authoritative dream figure in the Hall and Van de Castle listing of dream characters is the inclusion of God in the category of prominent persons. Hall's complete dream reports were made publicly available in the mid-1990s by Hall's protégé William Domhoff. More recent studies of dream reports, while providing more detail, continue to cite the Hall study favorably.

A soldier dreams: the trenches of WWI. Jan Styka (1858-1925).

In the Hall study, the most common emotion experienced in dreams was anxiety. Other emotions included abandonment, anger, fear, joy, and happiness. Negative emotions were much more common than positive ones. The Hall data analysis showed that sexual dreams occur no more than 10% of the time and are more prevalent in young to mid-teens. Another study showed that 8% of both men's and women's dreams have sexual content. In some cases, sexual dreams may result in orgasms or nocturnal emissions. These are colloquially known as "wet dreams."

The visual nature of dreams is generally highly phantasmagoric; that is, different locations and objects continuously blend into each other. The visuals (including locations, people, and objects) are generally reflective of a person's memories and experiences, but conversation can take on highly exaggerated and bizarre forms. Some dreams may even tell elaborate stories wherein the dreamer enters entirely new, complex worlds and awakes with ideas, thoughts and feelings never experienced prior to the dream.

People who are blind from birth do not have visual dreams. Their dream contents are related to other senses like hearing, touch, smell and taste, whichever are present since birth.

Neurophysiology

Dream study is popular with scientists exploring the mind-brain problem. Some "propose to reduce aspects of dream phenomenology to neurobiology." But current science cannot specify dream physiology in detail. Protocols in most nations restrict human brain research to non-invasive procedures. In the United States, invasive brain procedures with a human subject are allowed only when these are deemed necessary in surgical treatment to address medical needs of the same human subject. Non-invasive measures of brain activity like electroencephalogram (EEG) voltage averaging or cerebral blood flow cannot identify small but influential neuronal populations. Also, fMRI signals are too slow to explain how brains compute in real time.

Scientists researching some brain functions can work around current restrictions by examining animal subjects. As stated by the Society for Neuroscience, "Because no adequate alternatives exist, much of this research must be done on animal subjects." However, since animal dreaming can be only inferred, not confirmed, animal studies yield no hard facts to illuminate the neurophysiology of dreams. Examining human subjects with brain lesions can provide clues, but the lesion method cannot discriminate between the effects of destruction and disconnection and cannot target specific neuronal groups in heterogeneous regions like the brain stem.

Generation

Denied precision tools, obliged to depend on imaging, much dream research has succumbed to the law of the instrument. Studies detect an increase of blood flow in a specific brain region and then credit that region with a role in generating dreams. But pooling study results has led to the newer conclusion that dreaming involves large numbers of regions and pathways, which likely are different for different dream events.

Since eyes are closed during sleep, what generates dream vision? Image creation in the brain involves significant neural activity downstream from eye intake, and it is theorized that "the visual imagery of dreams is produced by activation during sleep of the same structures that generate complex visual imagery in waking perception."

Dreams do more than present visual images. They present them in a running narrative. Following their work with split-brain subjects, Gazzaniga and LeDoux postulated, without attempting to specify the neural mechanisms, a "left-brain interpreter" that seeks to create a plausible narrative from whatever electro-chemical signals reach the brain's left hemisphere. Sleep research has determined that some brain regions fully active during waking are, during REM sleep, activated only in a partial or fragmentary way. Drawing on this knowledge, textbook author James W. Kalat explains, "[A] dream represents the brain's effort to make sense of sparse and distorted information.... The cortex combines this haphazard input with whatever other activity was already occurring and does its best to synthesize a story that makes sense of the information." Neuroscientist Indre Viskontas is even more blunt, calling often bizarre dream content "just the result of your interpreter trying to create a story out of random neural signaling.”

Theories on function

For humans in the pre-classical era, and continuing for some non-literate populations into modern times, dreams are believed to have functioned as revealers of truths sourced during sleep from gods or other external entities. Ancient Egyptians believed that dreams were the best way to receive divine revelation, and thus they would induce (or "incubate") dreams. They went to sanctuaries and slept on special "dream beds" in hope of receiving advice, comfort, or healing from the gods. From a Darwinian perspective dreams would have to fulfill some kind of biological requirement, provide some benefit for natural selection to take place, or at least have no negative impact on fitness. Robert (1886), a physician from Hamburg, was the first who suggested that dreams are a need and that they have the function to erase (a) sensory impressions that were not fully worked up, and (b) ideas that were not fully developed during the day. In dreams, incomplete material is either removed (suppressed) or deepened and included into memory. Freud, whose dream studies focused on interpreting dreams, not explaining how or why humans dream, disputed Robert's hypothesis and proposed that dreams preserve sleep by representing as fulfilled those wishes that otherwise would awaken the dreamer. Freud wrote that dreams "serve the purpose of prolonging sleep instead of waking up. Dreams are the GUARDIANS of sleep and not its disturbers."

Grandmother and Granddaughter Dream (1839 or 1840). Taras Shevchenko

A turning point in theorizing about dream function came in 1953, when Science published the Aserinsky and Kleitman paper establishing REM sleep as a distinct phase of sleep and linking dreams to REM sleep. Until and even after publication of the Solms 2000 paper that certified the separability of REM sleep and dream phenomena, many studies purporting to uncover the function of dreams have in fact been studying not dreams but measurable REM sleep.

Theories of dream function since the identification of REM sleep include:

Hobson's and McCarley's 1977 activation-synthesis hypothesis, which proposed "a functional role for dreaming sleep in promoting some aspect of the learning process...."

Crick's and Mitchison's 1983 "reverse learning" theory, which states that dreams are like the cleaning-up operations of computers when they are offline, removing (suppressing) parasitic nodes and other "junk" from the mind during sleep.

Hartmann's 1995 proposal that dreams serve a "quasi-therapeutic" function, enabling the dreamer to process trauma in a safe place.

Revonsuo's 2000 threat simulation hypothesis, whose premise is that during much of human evolution, physical and interpersonal threats were serious, giving reproductive advantage to those who survived them. Dreaming aided survival by replicating these threats and providing the dreamer with practice in dealing with them.

Eagleman's and Vaughn's 2021 defensive activation theory, which says that, given the brain's neuroplasticity, dreams evolved as a visual hallucinatory activity during sleep's extended periods of darkness, busying the occipital lobe and thereby protecting it from possible appropriation by other, non-vision, sense operations.

Religious and other cultural contexts

Dreams figure prominently in major world religions. The dream experience for early humans, according to one interpretation, gave rise to the notion of a human "soul," a central element in much religious thought. J. W. Dunne wrote:

But there can be no reasonable doubt that the idea of a soul must have first arisen in the mind of primitive man as a result of observation of his dreams. Ignorant as he was, he could have come to no other conclusion but that, in dreams, he left his sleeping body in one universe and went wandering off into another. It is considered that, but for that savage, the idea of such a thing as a 'soul' would never have even occurred to mankind....

Hindu

In the Mandukya Upanishad, part of the Veda scriptures of Indian Hinduism, a dream is one of three states that the soul experiences during its lifetime, the other two states being the waking state and the sleep state. The earliest Upanishads, written before 300 BCE, emphasize two meanings of dreams. The first says that dreams are merely expressions of inner desires. The second is the belief of the soul leaving the body and being guided until awakened.

Abrahamic

Jacob's dream of a ladder of angels, c. 1690. Michael Willmann

In Judaism, dreams are considered part of the experience of the world that can be interpreted and from which lessons can be garnered. It is discussed in the Talmud, Tractate Berachot 55–60.

The ancient Hebrews connected their dreams heavily with their religion, though the Hebrews were monotheistic and believed that dreams were the voice of one God alone. Hebrews also differentiated between good dreams (from God) and bad dreams (from evil spirits). The Hebrews, like many other ancient cultures, incubated dreams in order to receive a divine revelation. For example, the Hebrew prophet Samuel would "lie down and sleep in the temple at Shiloh before the Ark and receive the word of the Lord." Most of the dreams in the Bible are in the Book of Genesis.

Christians mostly shared the beliefs of the Hebrews and thought that dreams were of a supernatural character because the Old Testament includes frequent stories of dreams with divine inspiration. The most famous of these dream stories was Jacob's dream of a ladder that stretches from Earth to Heaven. Many Christians preach that God can speak to people through their dreams. The famous glossary, the Somniale Danielis, written in the name of Daniel, attempted to teach Christian populations to interpret their dreams.

Iain R. Edgar has researched the role of dreams in Islam. He has argued that dreams play an important role in the history of Islam and the lives of Muslims, since dream interpretation is the only way that Muslims can receive revelations from God since the death of the last prophet, Muhammad. According to Edgar, Islam classifies three types of dreams. Firstly, there is the true dream (al-ru’ya), then the false dream, which may come from the devil (shaytan), and finally, the meaningless everyday dream (hulm). This last dream could be brought forth by the dreamer's ego or base appetite based on what they experienced in the real world. The true dream is often indicated by Islam's hadith tradition. In one narration by Aisha, the wife of the Prophet, it is said that the Prophet's dreams would come true like the ocean's waves. Just as in its predecessors, the Quran also recounts the story of Joseph and his unique ability to interpret dreams.

Buddhist

In Buddhism, ideas about dreams are similar to the classical and folk traditions in South Asia. The same dream is sometimes experienced by multiple people, as in the case of the Buddha-to-be, before he is leaving his home. It is described in the Mahāvastu that several of the Buddha's relatives had premonitory dreams preceding this. Some dreams are also seen to transcend time: the Buddha-to-be has certain dreams that are the same as those of previous Buddhas, the Lalitavistara states. In Buddhist literature, dreams often function as a "signpost" motif to mark certain stages in the life of the main character.

Buddhist views about dreams are expressed in the Pāli Commentaries and the Milinda Pañhā.

Other

Dreaming of the Tiger Spring (虎跑夢泉) Statue at Hupao Spring (Hupaomengquan) in Hangzhou, Zhejiang, China.

In Chinese history, people wrote of two vital aspects of the soul of which one is freed from the body during slumber to journey in a dream realm, while the other remained in the body. This belief and dream interpretation had been questioned since early times, such as by the philosopher Wang Chong (27–97 AD).

The Babylonians and Assyrians divided dreams into "good," which were sent by the gods, and "bad," sent by demons. A surviving collection of dream omens entitled Iškar Zaqīqu records various dream scenarios as well as prognostications of what will happen to the person who experiences each dream, apparently based on previous cases. Some list different possible outcomes, based on occasions in which people experienced similar dreams with different results. The Greeks shared their beliefs with the Egyptians on how to interpret good and bad dreams, and the idea of incubating dreams. Morpheus, the Greek god of dreams, also sent warnings and prophecies to those who slept at shrines and temples. The earliest Greek beliefs about dreams were that their gods physically visited the dreamers, where they entered through a keyhole, exiting the same way after the divine message was given.

Antiphon wrote the first known Greek book on dreams in the 5th century BCE. In that century, other cultures influenced Greeks to develop the belief that souls left the sleeping body. Hippocrates (469–399 BCE) had a simple dream theory: during the day, the soul receives images; during the night, it produces images. Greek philosopher Aristotle (384–322 BCE) believed dreams caused physiological activity. He thought dreams could analyze illness and predict diseases. Marcus Tullius Cicero, for his part, believed that all dreams are produced by thoughts and conversations a dreamer had during the preceding days. Cicero's Somnium Scipionis described a lengthy dream vision, which in turn was commented on by Macrobius in his Commentarii in Somnium Scipionis.

Herodotus in his The Histories, writes "The visions that occur to us in dreams are, more often than not, the things we have been concerned about during the day."

The Dreaming is a common term within the animist creation narrative of indigenous Australians for a personal, or group, creation and for what may be understood as the "timeless time" of formative creation and perpetual creating.

Some Indigenous American tribes and Mexican populations believe that dreams are a way of visiting and having contact with their ancestors. Some Native American tribes have used vision quests as a rite of passage, fasting and praying until an anticipated guiding dream was received, to be shared with the rest of the tribe upon their return.

Interpretation

Joseph Interprets Pharaoh's Dream c. 1896-1902. Jacques Joseph Tissot (1836-1902).

Beginning in the late 19th century, Austrian neurologist Sigmund Freud, founder of psychoanalysis, theorized that dreams reflect the dreamer's unconscious mind and specifically that dream content is shaped by unconscious wish fulfillment. He argued that important unconscious desires often relate to early childhood memories and experiences. Carl Jung and others expanded on Freud's idea that dream content reflects the dreamer's unconscious desires.

Dream interpretation can be a result of subjective ideas and experiences. One study found that most people believe that "their dreams reveal meaningful hidden truths." The researchers surveyed students in the United States, South Korea, and India, and found that 74% of Indians, 65% of South Koreans and 56% of Americans believed their dream content provided them with meaningful insight into their unconscious beliefs and desires. This Freudian view of dreaming was believed significantly more than theories of dreaming that attribute dream content to memory consolidation, problem-solving, or as a byproduct of unrelated brain activity. The same study found that people attribute more importance to dream content than to similar thought content that occurs while they are awake. Americans were more likely to report that they would miss their flight if they dreamt of their plane crashing than if they thought of their plane crashing the night before flying (while awake), and that they would be as likely to miss their flight if they dreamt of their plane crashing the night before their flight as if there was an actual plane crash on the route they intended to take. Participants in the study were more likely to perceive dreams to be meaningful when the content of dreams was in accordance with their beliefs and desires while awake. They were more likely to view a positive dream about a friend to be meaningful than a positive dream about someone they disliked, for example, and were more likely to view a negative dream about a person they disliked as meaningful than a negative dream about a person they liked.

According to surveys, it is common for people to feel their dreams are predicting subsequent life events. Psychologists have explained these experiences in terms of memory biases, namely a selective memory for accurate predictions and distorted memory so that dreams are retrospectively fitted onto life experiences. The multi-faceted nature of dreams makes it easy to find connections between dream content and real events. The term "veridical dream" has been used to indicate dreams that reveal or contain truths not yet known to the dreamer, whether future events or secrets.

In one experiment, subjects were asked to write down their dreams in a diary. This prevented the selective memory effect, and the dreams no longer seemed accurate about the future. Another experiment gave subjects a fake diary of a student with apparently precognitive dreams. This diary described events from the person's life, as well as some predictive dreams and some non-predictive dreams. When subjects were asked to recall the dreams they had read, they remembered more of the successful predictions than unsuccessful ones.

Images and literature

Graphic artists, writers and filmmakers all have found dreams to offer a rich vein for creative expression. In the West, artists' depictions of dreams in Renaissance and Baroque art often were related to Biblical narrative. Especially preferred by visual artists were the Jacob's Ladder dream in Genesis and St. Joseph's dreams in the Gospel according to Matthew.

Many later graphic artists have depicted dreams, including Japanese woodblock artist Hokusai (1760-1849) and Western European painters Rousseau (1844-1910), Picasso (1881-1973), and Dali (1904-1989).

In literature, dream frames were frequently used in medieval allegory to justify the narrative; The Book of the Duchess and The Vision Concerning Piers Plowman are two such dream visions. Even before them, in antiquity, the same device had been used by Cicero and Lucian of Samosata.

The cheshire cat, John Tenniel (1820-1914), illustration in Alice's Adventures in Wonderland, 1866 edition.

Dreams have also featured in fantasy and speculative fiction since the 19th century. One of the best-known dream worlds is Wonderland from Lewis Carroll's Alice's Adventures in Wonderland, as well as Looking-Glass Land from its sequel, Through the Looking-Glass. Unlike many dream worlds, Carroll's logic is like that of actual dreams, with transitions and flexible causality.

Other fictional dream worlds include the Dreamlands of H. P. Lovecraft's Dream Cycle and The Neverending Story's world of Fantastica, which includes places like the Desert of Lost Dreams, the Sea of Possibilities and the Swamps of Sadness. Dreamworlds, shared hallucinations and other alternate realities feature in a number of works by Philip K. Dick, such as The Three Stigmata of Palmer Eldritch and Ubik. Similar themes were explored by Jorge Luis Borges, for instance in The Circular Ruins.

Modern popular culture often conceives of dreams, as did Freud, as expressions of the dreamer's deepest fears and desires. In speculative fiction, the line between dreams and reality may be blurred even more in service to the story. Dreams may be psychically invaded or manipulated (Dreamscape, 1984; the Nightmare on Elm Street films, 1984–2010; Inception, 2010) or even come literally true (as in The Lathe of Heaven, 1971).

Lucidity

Lucid dreaming is the conscious perception of one's state while dreaming. In this state the dreamer may often have some degree of control over their own actions within the dream or even the characters and the environment of the dream. Dream control has been reported to improve with practiced deliberate lucid dreaming, but the ability to control aspects of the dream is not necessary for a dream to qualify as "lucid" — a lucid dream is any dream during which the dreamer knows they are dreaming. The occurrence of lucid dreaming has been scientifically verified.

"Oneironaut" is a term sometimes used for those who lucidly dream.

In 1975, psychologist Keith Hearne successfully recorded a communication from a dreamer experiencing a lucid dream. On April 12, 1975, after agreeing to move his eyes left and right upon becoming lucid, the subject and Hearne's co-author on the resulting article, Alan Worsley, successfully carried out this task. Years later, psychophysiologist Stephen LaBerge conducted similar work including:

  • Using eye signals to map the subjective sense of time in dreams.
  • Comparing the electrical activity of the brain while singing awake and while dreaming.
  • Studies comparing in-dream sex, arousal, and orgasm.

Communication between two dreamers has also been documented. The processes involved included EEG monitoring, ocular signaling, incorporation of reality in the form of red light stimuli and a coordinating website. The website tracked when both dreamers were dreaming and sent the stimulus to one of the dreamers where it was incorporated into the dream. This dreamer, upon becoming lucid, signaled with eye movements; this was detected by the website whereupon the stimulus was sent to the second dreamer, invoking incorporation into that dreamer's dream.

Recollection

Raphael's dream (1821). Johannes Riepenhausen and Franz Riepenhausen.

The recollection of dreams is extremely unreliable, though it is a skill that can be trained. Dreams can usually be recalled if a person is awakened while dreaming. Women tend to have more frequent dream recall than men. Dreams that are difficult to recall may be characterized by relatively little affect, and factors such as salience, arousal, and interference play a role in dream recall. Often, a dream may be recalled upon viewing or hearing a random trigger or stimulus. The salience hypothesis proposes that dream content that is salient, that is, novel, intense, or unusual, is more easily remembered. There is considerable evidence that vivid, intense, or unusual dream content is more frequently recalled. A dream journal can be used to assist dream recall, for personal interest or psychotherapy purposes.

Adults report remembering around two dreams per week, on average. Unless a dream is particularly vivid and if one wakes during or immediately after it, the content of the dream is typically not remembered. Recording or reconstructing dreams may one day assist with dream recall. Using the permitted non-invasive technologies, functional magnetic resonance imaging (fMRI) and electromyography (EMG), researchers have been able to identify basic dream imagery, dream speech activity and dream motor behavior (such as walking and hand movements).

In line with the salience hypothesis, there is considerable evidence that people who have more vivid, intense or unusual dreams show better recall. There is evidence that continuity of consciousness is related to recall. Specifically, people who have vivid and unusual experiences during the day tend to have more memorable dream content and hence better dream recall. People who score high on measures of personality traits associated with creativity, imagination, and fantasy, such as openness to experience, daydreaming, fantasy proneness, absorption, and hypnotic susceptibility, tend to show more frequent dream recall. There is also evidence for continuity between the bizarre aspects of dreaming and waking experience. That is, people who report more bizarre experiences during the day, such as people high in schizotypy (psychosis proneness), have more frequent dream recall and also report more frequent nightmares.

Miscellany

A Dream of a Girl Before a Sunrise c. 1830-1833 by Karl Bryullov (1799-1852)

Illusion of reality

Some philosophers have proposed that what we think of as the "real world" could be or is an illusion (an idea known as the skeptical hypothesis about ontology). The first recorded mention of the idea was in the 4th century BCE by Zhuangzi, and in Eastern philosophy, the problem has been named the "Zhuangzi Paradox."

He who dreams of drinking wine may weep when morning comes; he who dreams of weeping may in the morning go off to hunt. While he is dreaming he does not know it is a dream, and in his dream he may even try to interpret a dream. Only after he wakes does he know it was a dream. And someday there will be a great awakening when we know that this is all a great dream. Yet the stupid believe they are awake, busily and brightly assuming they understand things, calling this man ruler, that one herdsman—how dense! Confucius and you are both dreaming! And when I say you are dreaming, I am dreaming, too. Words like these will be labeled the Supreme Swindle. Yet, after ten thousand generations, a great sage may appear who will know their meaning, and it will still be as though he appeared with astonishing speed.

The idea also is discussed in Hindu and Buddhist writings. It was formally introduced to Western philosophy by Descartes in the 17th century in his Meditations on First Philosophy.

Absent-minded transgression

Dreams of absent-minded transgression (DAMT) are dreams wherein the dreamer absent-mindedly performs an action that he or she has been trying to stop (one classic example is of a quitting smoker having dreams of lighting a cigarette). Subjects who have had DAMT have reported waking with intense feelings of guilt. One study found a positive association between having these dreams and successfully stopping the behavior.

Daydreams

Dante Meditating, 1852, by Joseph Noel Paton.

A daydream is a visionary fantasy, especially one of happy, pleasant thoughts, hopes or ambitions, imagined as coming to pass, and experienced while awake. There are many different types of daydreams, and there is no consistent definition amongst psychologists. The general public also uses the term for a broad variety of experiences. Research by Harvard psychologist Deirdre Barrett has found that people who experience vivid dreamlike mental images reserve the word for these, whereas many other people refer to milder imagery, realistic future planning, review of past memories or just "spacing out"—i.e. one's mind going relatively blank—when they talk about "daydreaming."'

While daydreaming has long been derided as a lazy, non-productive pastime, it is now commonly acknowledged that daydreaming can be constructive in some contexts. There are numerous examples of people in creative or artistic careers, such as composers, novelists and filmmakers, developing new ideas through daydreaming. Similarly, research scientists, mathematicians and physicists have developed new ideas by daydreaming about their subject areas.

Hallucination

A hallucination, in the broadest sense of the word, is a perception in the absence of a stimulus. In a stricter sense, hallucinations are perceptions in a conscious and awake state, in the absence of external stimuli, and have qualities of real perception, in that they are vivid, substantial, and located in external objective space. The latter definition distinguishes hallucinations from the related phenomena of dreaming, which does not involve wakefulness.

Nightmare

Woman having a nightmare. Jean-Pierre Simon (1764-1810 or 1813).

A nightmare is an unpleasant dream that can cause a strong negative emotional response from the mind, typically fear or horror, but also despair, anxiety and great sadness. The dream may contain situations of danger, discomfort, psychological or physical terror. Sufferers usually awaken in a state of distress and may be unable to return to sleep for a prolonged period of time.

Night terror

A night terror, also known as a sleep terror or pavor nocturnus, is a parasomnia disorder that predominantly affects children, causing feelings of terror or dread. Night terrors should not be confused with nightmares, which are bad dreams that cause the feeling of horror or fear.

Déjà vu

One theory of déjà vu attributes the feeling of having previously seen or experienced something to having dreamed about a similar situation or place, and forgetting about it until one seems to be mysteriously reminded of the situation or the place while awake.

See also

 

Adenosine triphosphate

From Wikipedia, the free encyclopedia
 
Adenosine-5'-triphosphate
Adenosintriphosphat protoniert.svg
ATP-xtal-3D-balls.png
ATP-xtal-3D-vdW.png
Names
IUPAC name
Adenosine 5′-(tetrahydrogen triphosphate)
Preferred IUPAC name
O1-{[(2R,3S,4R,5R)-5-(6-Amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl} tetrahydrogen triphosphate
Identifiers
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
DrugBank
ECHA InfoCard 100.000.258 Edit this at Wikidata
KEGG
UNII


Properties
C10H16N5O13P3
Molar mass 507.18 g/mol
Density 1.04 g/cm3 (disodium salt)
Melting point 187 °C (369 °F; 460 K) disodium salt; decomposes
Acidity (pKa) 6.5
UV-vismax) 259 nm
Absorbance ε259 = 15.4 mM−1 cm−1

A chemical formula
Interactive animation of the structure of ATP

Adenosine triphosphate (ATP) is an organic compound and hydrotrope that provides energy to drive many processes in living cells, such as muscle contraction, nerve impulse propagation, condensate dissolution, and chemical synthesis. Found in all known forms of life, ATP is often referred to as the "molecular unit of currency" of intracellular energy transfer. When consumed in metabolic processes, it converts either to adenosine diphosphate (ADP) or to adenosine monophosphate (AMP). Other processes regenerate ATP so that the human body recycles its own body weight equivalent in ATP each day. It is also a precursor to DNA and RNA, and is used as a coenzyme.

From the perspective of biochemistry, ATP is classified as a nucleoside triphosphate, which indicates that it consists of three components: a nitrogenous base (adenine), the sugar ribose, and the triphosphate.

Structure

ATP consists of an adenine attached by the 9-nitrogen atom to the 1′ carbon atom of a sugar (ribose), which in turn is attached at the 5' carbon atom of the sugar to a triphosphate group. In its many reactions related to metabolism, the adenine and sugar groups remain unchanged, but the triphosphate is converted to di- and monophosphate, giving respectively the derivatives ADP and AMP. The three phosphoryl groups are referred to as the alpha (α), beta (β), and, for the terminal phosphate, gamma (γ).

In neutral solution, ionized ATP exists mostly as ATP4−, with a small proportion of ATP3−.

Binding of metal cations to ATP

Being polyanionic and featuring a potentially chelating polyphosphate group, ATP binds metal cations with high affinity. The binding constant for Mg2+
is (9554). The binding of a divalent cation, almost always magnesium, strongly affects the interaction of ATP with various proteins. Due to the strength of the ATP-Mg2+ interaction, ATP exists in the cell mostly as a complex with Mg2+
bonded to the phosphate oxygen centers.

A second magnesium ion is critical for ATP binding in the kinase domain. The presence of Mg2+ regulates kinase activity.

Chemical properties

Salts of ATP can be isolated as colorless solids.

The cycles of synthesis and degradation of ATP; 2 and 1 represent input and output of energy, respectively.

ATP is stable in aqueous solutions between pH 6.8 and 7.4, in the absence of catalysts. At more extreme pHs, it rapidly hydrolyses to ADP and phosphate. Living cells maintain the ratio of ATP to ADP at a point ten orders of magnitude from equilibrium, with ATP concentrations fivefold higher than the concentration of ADP. In the context of biochemical reactions, the P-O-P bonds are frequently referred to as high-energy bonds.

Reactive aspects

The hydrolysis of ATP into ADP and inorganic phosphate releases 30.5 kJ/mol of enthalpy, with a change in free energy of 3.4 kJ/mol. The energy released by cleaving either a phosphate (Pi) or pyrophosphate (PPi) unit from ATP at standard state of 1 M are:

ATP + H
2
O
→ ADP + Pi   ΔG° = −30.5 kJ/mol (−7.3 kcal/mol)
ATP + H
2
O
→ AMP + PPi   ΔG° = −45.6 kJ/mol (−10.9 kcal/mol)

These abbreviated equations can be written more explicitly (R = adenosyl):

[RO-P(O)2-O-P(O)2-O-PO3]4− + H
2
O
→ [RO-P(O)2-O-PO3]3− + [PO4]3− + 2 H+
[RO-P(O)2-O-P(O)2-O-PO3]4− + H
2
O
→ [RO-PO3]2− + [O3P-O-PO3]4− + 2 H+
This image shows a 360-degree rotation of a single, gas-phase magnesium-ATP chelate with a charge of −2. The anion was optimized at the UB3LYP/6-311++G(d,p) theoretical level and the atomic connectivity modified by the human optimizer to reflect the probable electronic structure.

Production from AMP and ADP

Production, aerobic conditions

A typical intracellular concentration of ATP is hard to pin down, however, reports have shown there to be 1–10  μmol per gram of tissue in a variety of eukaryotes. The dephosphorylation of ATP and rephosphorylation of ADP and AMP occur repeatedly in the course of aerobic metabolism.

ATP can be produced by a number of distinct cellular processes; the three main pathways in eukaryotes are (1) glycolysis, (2) the citric acid cycle/oxidative phosphorylation, and (3) beta-oxidation. The overall process of oxidizing glucose to carbon dioxide, the combination of pathways 1 and 2, known as cellular respiration, produces about 30 equivalents of ATP from each molecule of glucose.

ATP production by a non-photosynthetic aerobic eukaryote occurs mainly in the mitochondria, which comprise nearly 25% of the volume of a typical cell.

Glycolysis

In glycolysis, glucose and glycerol are metabolized to pyruvate. Glycolysis generates two equivalents of ATP through substrate phosphorylation catalyzed by two enzymes, PGK and pyruvate kinase. Two equivalents of NADH are also produced, which can be oxidized via the electron transport chain and result in the generation of additional ATP by ATP synthase. The pyruvate generated as an end-product of glycolysis is a substrate for the Krebs Cycle.

Glycolysis is viewed as consisting of two phases with five steps each. In phase 1, "the preparatory phase", glucose is converted to 2 d-glyceraldehyde -3-phosphate (g3p). One ATP is invested in Step 1, and another ATP is invested in Step 3. Steps 1 and 3 of glycolysis are referred to as "Priming Steps". In Phase 2, two equivalents of g3p are converted to two pyruvates. In Step 7, two ATP are produced. Also, in Step 10, two further equivalents of ATP are produced. In Steps 7 and 10, ATP is generated from ADP. A net of two ATPs is formed in the glycolysis cycle. The glycolysis pathway is later associated with the Citric Acid Cycle which produces additional equivalents of ATP.

Regulation

In glycolysis, hexokinase is directly inhibited by its product, glucose-6-phosphate, and pyruvate kinase is inhibited by ATP itself. The main control point for the glycolytic pathway is phosphofructokinase (PFK), which is allosterically inhibited by high concentrations of ATP and activated by high concentrations of AMP. The inhibition of PFK by ATP is unusual since ATP is also a substrate in the reaction catalyzed by PFK; the active form of the enzyme is a tetramer that exists in two conformations, only one of which binds the second substrate fructose-6-phosphate (F6P). The protein has two binding sites for ATP – the active site is accessible in either protein conformation, but ATP binding to the inhibitor site stabilizes the conformation that binds F6P poorly. A number of other small molecules can compensate for the ATP-induced shift in equilibrium conformation and reactivate PFK, including cyclic AMP, ammonium ions, inorganic phosphate, and fructose-1,6- and -2,6-biphosphate.

Citric acid cycle

In the mitochondrion, pyruvate is oxidized by the pyruvate dehydrogenase complex to the acetyl group, which is fully oxidized to carbon dioxide by the citric acid cycle (also known as the Krebs cycle). Every "turn" of the citric acid cycle produces two molecules of carbon dioxide, one equivalent of ATP guanosine triphosphate (GTP) through substrate-level phosphorylation catalyzed by succinyl-CoA synthetase, as succinyl- CoA is converted to Succinate, three equivalents of NADH, and one equivalent of FADH2. NADH and FADH2 are recycled (to NAD+ and FAD, respectively), generating additional ATP by oxidative phosphorylation. The oxidation of NADH results in the synthesis of 2–3 equivalents of ATP, and the oxidation of one FADH2 yields between 1–2 equivalents of ATP. The majority of cellular ATP is generated by this process. Although the citric acid cycle itself does not involve molecular oxygen, it is an obligately aerobic process because O2 is used to recycle the NADH and FADH2 and provides the chemical energy driving the process. In the absence of oxygen, the citric acid cycle ceases.

The generation of ATP by the mitochondrion from cytosolic NADH relies on the malate-aspartate shuttle (and to a lesser extent, the glycerol-phosphate shuttle) because the inner mitochondrial membrane is impermeable to NADH and NAD+. Instead of transferring the generated NADH, a malate dehydrogenase enzyme converts oxaloacetate to malate, which is translocated to the mitochondrial matrix. Another malate dehydrogenase-catalyzed reaction occurs in the opposite direction, producing oxaloacetate and NADH from the newly transported malate and the mitochondrion's interior store of NAD+. A transaminase converts the oxaloacetate to aspartate for transport back across the membrane and into the intermembrane space.

In oxidative phosphorylation, the passage of electrons from NADH and FADH2 through the electron transport chain releases the chemical energy of O2 to pump protons out of the mitochondrial matrix and into the intermembrane space. This pumping generates a proton motive force that is the net effect of a pH gradient and an electric potential gradient across the inner mitochondrial membrane. Flow of protons down this potential gradient – that is, from the intermembrane space to the matrix – yields ATP by ATP synthase. Three ATP are produced per turn.

Although oxygen consumption appears fundamental for the maintenance of the proton motive force, in the event of oxygen shortage (hypoxia), intracellular acidosis (mediated by enhanced glycolytic rates and ATP hydrolysis), contributes to mitochondrial membrane potential and directly drives ATP synthesis.

Most of the ATP synthesized in the mitochondria will be used for cellular processes in the cytosol; thus it must be exported from its site of synthesis in the mitochondrial matrix. ATP outward movement is favored by the membrane's electrochemical potential because the cytosol has a relatively positive charge compared to the relatively negative matrix. For every ATP transported out, it costs 1 H+. Producing one ATP costs about 3 H+. Therefore, making and exporting one ATP requires 4H+. The inner membrane contains an antiporter, the ADP/ATP translocase, which is an integral membrane protein used to exchange newly synthesized ATP in the matrix for ADP in the intermembrane space. This translocase is driven by the membrane potential, as it results in the movement of about 4 negative charges out across the mitochondrial membrane in exchange for 3 negative charges moved inside. However, it is also necessary to transport phosphate into the mitochondrion; the phosphate carrier moves a proton in with each phosphate, partially dissipating the proton gradient. After completing glycolysis, the citric acid cycle, the electron transport chain, and oxidative phosphorylation, approximately 30–38 ATP molecules are produced per glucose.

Regulation

The citric acid cycle is regulated mainly by the availability of key substrates, particularly the ratio of NAD+ to NADH and the concentrations of calcium, inorganic phosphate, ATP, ADP, and AMP. Citrate – the ion that gives its name to the cycle – is a feedback inhibitor of citrate synthase and also inhibits PFK, providing a direct link between the regulation of the citric acid cycle and glycolysis.

Beta oxidation

In the presence of air and various cofactors and enzymes, fatty acids are converted to acetyl-CoA. The pathway is called beta-oxidation. Each cycle of beta-oxidation shortens the fatty acid chain by two carbon atoms and produces one equivalent each of acetyl-CoA, NADH, and FADH2. The acetyl-CoA is metabolized by the citric acid cycle to generate ATP, while the NADH and FADH2 are used by oxidative phosphorylation to generate ATP. Dozens of ATP equivalents are generated by the beta-oxidation of a single long acyl chain.

Regulation

In oxidative phosphorylation, the key control point is the reaction catalyzed by cytochrome c oxidase, which is regulated by the availability of its substrate – the reduced form of cytochrome c. The amount of reduced cytochrome c available is directly related to the amounts of other substrates:

which directly implies this equation:

Thus, a high ratio of [NADH] to [NAD+] or a high ratio of [ADP][Pi] to [ATP] imply a high amount of reduced cytochrome c and a high level of cytochrome c oxidase activity. An additional level of regulation is introduced by the transport rates of ATP and NADH between the mitochondrial matrix and the cytoplasm.

Ketosis

Ketone bodies can be used as fuels, yielding 22 ATP and 2 GTP molecules per acetoacetate molecule when oxidized in the mitochondria. Ketone bodies are transported from the liver to other tissues, where acetoacetate and beta-hydroxybutyrate can be reconverted to acetyl-CoA to produce reducing equivalents (NADH and FADH2), via the citric acid cycle. Ketone bodies cannot be used as fuel by the liver, because the liver lacks the enzyme β-ketoacyl-CoA transferase, also called thiolase. Acetoacetate in low concentrations is taken up by the liver and undergoes detoxification through the methylglyoxal pathway which ends with lactate. Acetoacetate in high concentrations is absorbed by cells other than those in the liver and enters a different pathway via 1,2-propanediol. Though the pathway follows a different series of steps requiring ATP, 1,2-propanediol can be turned into pyruvate.

Production, anaerobic conditions

Fermentation is the metabolism of organic compounds in the absence of air. It involves substrate-level phosphorylation in the absence of a respiratory electron transport chain. The equation for the reaction of glucose to form lactic acid is:

C
6
H
12
O
6
+ 2 ADP + 2 Pi → 2 CH
3
CH(OH)COOH
+ 2 ATP + 2 H
2
O

Anaerobic respiration is respiration in the absence of O
2
. Prokaryotes can utilize a variety of electron acceptors. These include nitrate, sulfate, and carbon dioxide.

ATP replenishment by nucleoside diphosphate kinases

ATP can also be synthesized through several so-called "replenishment" reactions catalyzed by the enzyme families of nucleoside diphosphate kinases (NDKs), which use other nucleoside triphosphates as a high-energy phosphate donor, and the ATP:guanido-phosphotransferase family.

ATP production during photosynthesis

In plants, ATP is synthesized in the thylakoid membrane of the chloroplast. The process is called photophosphorylation. The "machinery" is similar to that in mitochondria except that light energy is used to pump protons across a membrane to produce a proton-motive force. ATP synthase then ensues exactly as in oxidative phosphorylation. Some of the ATP produced in the chloroplasts is consumed in the Calvin cycle, which produces triose sugars.

ATP recycling

The total quantity of ATP in the human body is about 0.1 mol/L. The majority of ATP is recycled from ADP by the aforementioned processes. Thus, at any given time, the total amount of ATP + ADP remains fairly constant.

The energy used by human cells in an adult requires the hydrolysis of 100 to 150 mol/L of ATP daily, which means a human will typically use their body weight worth of ATP over the course of the day. Each equivalent of ATP is recycled 1000–1500 times during a single day (150 / 0.1 = 1500), at approximately 9×1020 molecules/s.

An example of the Rossmann fold, a structural domain of a decarboxylase enzyme from the bacterium Staphylococcus epidermidis (PDB: 1G5Q​) with a bound flavin mononucleotide cofactor.

Biochemical functions

Intracellular signaling

ATP is involved in signal transduction by serving as substrate for kinases, enzymes that transfer phosphate groups. Kinases are the most common ATP-binding proteins. They share a small number of common folds. Phosphorylation of a protein by a kinase can activate a cascade such as the mitogen-activated protein kinase cascade.

ATP is also a substrate of adenylate cyclase, most commonly in G protein-coupled receptor signal transduction pathways and is transformed to second messenger, cyclic AMP, which is involved in triggering calcium signals by the release of calcium from intracellular stores. This form of signal transduction is particularly important in brain function, although it is involved in the regulation of a multitude of other cellular processes.

DNA and RNA synthesis

ATP is one of four monomers required in the synthesis of RNA. The process is promoted by RNA polymerases. A similar process occurs in the formation of DNA, except that ATP is first converted to the deoxyribonucleotide dATP. Like many condensation reactions in nature, DNA replication and DNA transcription also consume ATP.

Amino acid activation in protein synthesis

Aminoacyl-tRNA synthetase enzymes consume ATP in the attachment tRNA to amino acids, forming aminoacyl-tRNA complexes. Aminoacyl transferase binds AMP-amino acid to tRNA. The coupling reaction proceeds in two steps:

  1. aa + ATP ⟶ aa-AMP + PPi
  2. aa-AMP + tRNA ⟶ aa-tRNA + AMP

The amino acid is coupled to the penultimate nucleotide at the 3′-end of the tRNA (the A in the sequence CCA) via an ester bond (roll over in illustration).

ATP binding cassette transporter

Transporting chemicals out of a cell against a gradient is often associated with ATP hydrolysis. Transport is mediated by ATP binding cassette transporters. The human genome encodes 48 ABC transporters, that are used for exporting drugs, lipids, and other compounds.

Extracellular signalling and neurotransmission

Cells secrete ATP to communicate with other cells in a process called purinergic signalling. ATP serves as a neurotransmitter in many parts of the nervous system, modulates ciliary beating, affects vascular oxygen supply etc. ATP is either secreted directly across the cell membrane through channel proteins or is pumped into vesicles which then fuse with the membrane. Cells detect ATP using the purinergic receptor proteins P2X and P2Y.

Protein solubility

ATP has recently been proposed to act as a biological hydrotrope and has been shown to affect proteome-wide solubility.

ATP analogues

Biochemistry laboratories often use in vitro studies to explore ATP-dependent molecular processes. ATP analogs are also used in X-ray crystallography to determine a protein structure in complex with ATP, often together with other substrates.

Enzyme inhibitors of ATP-dependent enzymes such as kinases are needed to examine the binding sites and transition states involved in ATP-dependent reactions.

Most useful ATP analogs cannot be hydrolyzed as ATP would be; instead, they trap the enzyme in a structure closely related to the ATP-bound state. Adenosine 5′-(γ-thiotriphosphate) is an extremely common ATP analog in which one of the gamma-phosphate oxygens is replaced by a sulfur atom; this anion is hydrolyzed at a dramatically slower rate than ATP itself and functions as an inhibitor of ATP-dependent processes. In crystallographic studies, hydrolysis transition states are modeled by the bound vanadate ion.

Caution is warranted in interpreting the results of experiments using ATP analogs, since some enzymes can hydrolyze them at appreciable rates at high concentration.

Medical use

ATP is used intravenously for some heart related conditions.

History

ATP was discovered in 1929 by Karl Lohmann and Jendrassik and, independently, by Cyrus Fiske and Yellapragada Subba Rao of Harvard Medical School, both teams competing against each other to find an assay for phosphorus.

It was proposed to be the intermediary between energy-yielding and energy-requiring reactions in cells by Fritz Albert Lipmann in 1941.

It was first synthesized in the laboratory by Alexander Todd in 1948.

The Nobel Prize in Chemistry 1997 was divided, one half jointly to Paul D. Boyer and John E. Walker "for their elucidation of the enzymatic mechanism underlying the synthesis of adenosine triphosphate (ATP)" and the other half to Jens C. Skou "for the first discovery of an ion-transporting enzyme, Na+, K+ -ATPase."

See also

 

Archetype

From Wikipedia, the free encyclopedia https://en.wikipedia.org/wiki/Archetype The concept of an archetyp...