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Thursday, February 23, 2023

Airway management

From Wikipedia, the free encyclopedia
Airway management
Glidescope 02.JPG
Photograph of an anesthesiologist using the Glidescope video laryngoscope to intubate the trachea of a morbidly obese elderly person with challenging airway anatomy

Airway management includes a set of maneuvers and medical procedures performed to prevent and relieve airway obstruction. This ensures an open pathway for gas exchange between a patient's lungs and the atmosphere. This is accomplished by either clearing a previously obstructed airway; or by preventing airway obstruction in cases such as anaphylaxis, the obtunded patient, or medical sedation. Airway obstruction can be caused by the tongue, foreign objects, the tissues of the airway itself, and bodily fluids such as blood and gastric contents (aspiration).

Airway management is commonly divided into two categories: basic and advanced.

Basic techniques are generally non-invasive and do not require specialized medical equipment or advanced training. These include head and neck maneuvers to optimize ventilation, abdominal thrusts, and back blows.

Advanced techniques require specialized medical training and equipment, and are further categorized anatomically into supraglottic devices (such as oropharyngeal and nasopharyngeal airways), infraglottic techniques (such as tracheal intubation), and surgical methods (such as cricothyrotomy and tracheotomy).

Airway management is a primary consideration in the fields of cardiopulmonary resuscitation, anaesthesia, emergency medicine, intensive care medicine, neonatology, and first aid. The "A" in the ABC treatment mnemonic is for airway.

Basic airway management

Basic airway management involves maneuvers that do not require specialized medical equipment (in contrast to advanced airway management). It is mainly used in first aid since it is non-invasive, quick, and relatively simple to perform. The simplest way to determine if the airway is obstructed is by assessing whether the patient is able to speak. Basic airway management can be divided into treatment and prevention of an obstruction in the airway.

Back slaps and abdominal thrusts are performed to relieve airway obstruction by foreign objects
 
Inward and upward force during abdominal thrusts

Treatment

Treatment includes different maneuvers that aim to remove the foreign body that is obstructing the airway. This type of obstruction most often occurs when someone is eating or drinking. Most modern protocols, including those of the American Heart Association, American Red Cross and the European Resuscitation Council, recommend several stages, designed to apply increasingly more pressure. Most protocols recommend first encouraging the victims to cough, and allowing them an opportunity to spontaneously clear the foreign body if they are coughing forcefully. If the person's airway continues to be blocked, more forceful maneuvers such as hard back slaps and abdominal thrusts (Heimlich maneuver) can be performed. Some guidelines recommend alternating between abdominal thrusts and back slaps while others recommend the same starting with the back slaps first. Having the person lean forward reduces the chances of the foreign body going back down the airway when coming up.

Performing abdominal thrusts on someone else involves standing behind them, and providing inward and upward forceful compressions in the upper abdomen, concretely in the area located between the chest and the belly button. The rescuer usually gives the compressions using a fist that is grasped with the other hand.

Abdominal thrusts can also be performed on oneself with the help of the objects near, for example: by leaning over a chair. Anyway, when the choking victim is oneself, one of the more reliable options is the usage of any specific anti-choking device. In adults, there is limited evidence that the head down position can be used for self-treatment of suffocation and appears to be an option only if other maneuvers do not work. In contrast, in children under 1 it is recommended that the child be placed in a head down position as this appears to help increase the effectiveness of back slaps and abdominal thrusts.

When the victim can not receive pressures on the abdomen (it can happen in case of pregnancy or excessive obesity, for example), chest thrusts are advised instead of abdominal thrusts. The chest thrusts are the same type of compressions but applied on the lower half of the chest bone (not in the very extreme, which is a point named xiphoid process and could be broken).

The American Medical Association and Australian Resuscitation Council advocate sweeping the fingers across the back of the throat to attempt to dislodge airway obstructions, once the choking victim becomes unconscious. However, many modern protocols and literature recommend against the use of the finger sweep. If the person is conscious, they should be able to remove the foreign object themselves, and if they are unconscious, a finger sweep can cause more harm. A finger sweep can push the foreign body further down the airway, making it harder to remove, or cause aspiration by inducing the person to vomit. Additionally, there is the potential for harm to the rescuer if they are unable to clearly see the oral cavity (for example, cutting a finger on jagged teeth).

Prevention

The head-tilt/chin-lift is the most reliable method of opening the airway.
 
The jaw thrust maneuver can also open up the airway with minimal spine manipulation

Prevention techniques focus on preventing airway obstruction by the tongue and reducing the likelihood of aspiration of stomach contents or blood. The head-tilt/chin-lift and jaw-thrust maneuvers are useful for the former while the recovery position is useful for the latter. If head-tilt/chin-lift and jaw-thrust maneuvers are performed with any objects in the airways it may dislodge them further down the airways and thereby cause more blockage and harder removal.

The head-tilt/chin-lift is the primary maneuver used in any patient in whom cervical spine injury is not a concern. This maneuver involves flexion of the neck and extension of the head at Atlanto-occipital joint (also called the sniffing position), which opens up the airway by lifting the tongue away from the back of the throat. Placing a folded towel behind the head accomplishes the same result.

All forms of the recovery position share basic principles. The head is in a dependent position so that fluid can drain from the patient's airway; the chin is well up to keep the epiglottis opened. Arms and legs are locked to stabilize the position of the patient

The jaw-thrust maneuver is an effective airway technique, particularly in the patient in whom cervical spine injury is a concern. It is easiest when the patient is positioned supine. The practitioner places their index and middle fingers behind the angle of the mandible to physically push the posterior aspects of the mandible upwards while their thumbs push down on the chin to open the mouth. When the mandible is displaced forward, it pulls the tongue forward and prevents it from occluding the entrance to the trachea.

The recovery position is an important prevention technique for an unconscious person that is breathing casually. This position entails having the person lie in a stable position on their side with the head in a dependent position so fluids do not drain down the airway, reducing the risk of aspiration.

Most airway maneuvers are associated with some movement of the cervical spine. When there is a possibility of cervical injury, collars are used to help hold the head in-line. Most of these airway maneuvers are associated with some movement of the cervical spine. Even though cervical collars can cause problems maintaining an airway and maintaining a blood pressure, it is not recommended to remove the collar without adequate personnel to manually hold the head in place.

Advanced airway management

In contrast to basic airway management maneuvers such as head-tilt or jaw-thrust, advanced airway management relies on the use of medical equipment. Advanced airway management can be performed "blindly" or with visualization of the glottis by using a laryngoscope. Advanced airway management is frequently performed in the critically injured, those with extensive pulmonary disease, or anesthetized patients to facilitate oxygenation and mechanical ventilation. Additionally, implementation of a cuffing system is used to prevent the possibility of asphyxiation or airway obstruction.

Many methods are used in Advanced airway management. Examples in increasing order of invasiveness include the use of supraglottic devices such as oropharyngeal or nasopharyngeal airways, infraglottic techniques such as tracheal intubation and finally surgical methods.

Removal of foreign objects

Foreign objects can be removed with a Magill forceps under inspection of the airway with a laryngoscope

The ingestion and aspiration of foreign objects pose a common and dangerous problem in young children. It remains one of the leading cause of death in children under the age of 5. Common food items (baby carrots, peanuts, etc.) and household objects (coins, metals, etc.) may lodge in various levels of the airway tract and cause significant obstruction of the airway. Complete obstruction of the airway represents a medical emergency. During such crisis, caretakers may attempt back blows, abdominal thrust, or the Heimlich maneuver to dislodge the inhaled object and reestablish airflow into the lungs.

In the hospital setting, healthcare practitioners will make the diagnosis of foreign body aspiration from the medical history and physical exam findings. In some cases, providers will order chest radiographs, which may show signs of air-trapping in the affected lung. In advanced airway management, the inhaled foreign objects, however, are either removed by using a simple plastic suction device (such as a Yankauer suction tip) or under direct inspection of the airway with a laryngoscope or bronchoscope. If removal is not possible, other surgical methods should be considered.

Supraglottic techniques

Supraglottic techniques use devices that are designed to have the distal tip resting above the level of the glottis when in its final seated position. Supraglottic devices ensure patency of the upper respiratory tract without entry into the trachea by bridging the oral and pharyngeal spaces. There are many methods of subcategorizing this family of devices including route of insertion, absence or presence of a cuff, and anatomic location of the device's distal end. The most commonly used devices are laryngeal masks and supraglottic tubes, such as oropharyngeal (OPA) and nasopharyngeal airways (NPA). In general, features of an ideal supraglottic airway include the ability to bypass the upper airway, produce low airway resistance, allow both positive pressure as well as spontaneous ventilation, protect the respiratory tract from gastric and nasal secretions, be easily inserted by even a nonspecialist, produce high first-time insertion rate, remain in place once in seated position, minimize risk of aspiration, and produce minimal side effects.

A nasopharyngeal airway is a soft rubber or plastic tube that is passed through the nose and into the posterior pharynx. Nasopharyngeal airways are produced in various lengths and diameters to accommodate for gender and anatomical variations. Functionally, the device is gently inserted through a patient's nose after careful lubrication with a viscous lidocaine gel. Successful placement will facilitate spontaneous ventilation, masked ventilation, or machine assisted ventilation with a modified nasopharyngeal airway designed with special attachments at the proximal end. Patients generally tolerate NPAs very well. NPAs are preferred over OPAs when the patient's jaw is clenched or if the patient is semiconscious and cannot tolerate an OPA. NPAs, however, are generally not recommended if there is suspicion of a fracture to the base of the skull. In these circumstances, insertion of the NPA can cause neurological damage by entering the cranium during placement. There is no consensus, however, regarding the risk of neurological damage secondary to a basilar skull fracture compared to hypoxia due to insufficient airway management. Other complications of Nasopharyngeal airways use includes laryngospasm, epistaxis, vomiting, and tissue necrosis with prolonged use.

Oropharyngeal airways in a range of sizes

Oropharyngeal airways are curved, rigid plastic devices, inserted into the patient's mouth. Oropharyngeal airways are produced in various lengths and diameters to accommodate for gender and anatomical variations. It is especially useful in patients with excessive tongue and other soft tissues. OPAs prevent airway obstruction by ensuring that the patient's tongue does not obstruct the epiglottis by creating a conduit. Because an oropharyngeal airway can mechanically stimulate the gag reflex, it should only be used in a deeply sedated or unresponsive patient to avoid vomiting and aspiration. Careful attention must be made while inserting an OPA. The user must avoid pushing the tongue further down the patient's throat. This is usually done by inserting the OPA with its curve facing cephalad and rotating it 180 degrees as you enter the posterior pharynx.

Extraglottic devices are another family of supraglottic devices that are inserted through the mouth to sit on top of the larynx. Extraglottic devices are used in the majority of operative procedures performed under general anaesthesia. Compared to a cuffed tracheal tube, extraglottic devices provide less protection against aspiration but are more easily inserted and causes less laryngeal trauma. Limitations of extraglottic devices arise in morbidly obese patients, lengthy surgical procedures, surgery involving the airways, laparoscopic procedures and others due to its bulkier design and inferior ability to prevent aspiration. In these circumstances, endotracheal intubation is generally preferred. The most commonly used extraglottic device is the laryngeal mask airway (LMA). An LMA is a cuffed perilaryngeal sealer that is inserted into the mouth and set over the glottis. Once it is in its seated position, the cuff is inflated. Other variations include devices with oesophageal access ports, so that a separate tube can be inserted from the mouth to the stomach to decompress accumulated gases and drain liquid contents. Other variations of the device can have an endotracheal tube passed through the LMA and into the trachea.

Infraglottic techniques

A cuffed endotracheal tube used in tracheal intubation

In contrast to supraglottic devices, infraglottic devices create a conduit between the mouth, passing through the glottis, and into the trachea. There are many infraglottic methods available and the chosen technique is reliant on the accessibility of medical equipment, competence of the clinician and the patient's injury or disease. Tracheal intubation, often simply referred to as intubation, is the placement of a flexible plastic or rubber tube into the trachea to maintain an open airway or to serve as a conduit through which to administer certain drugs. The most widely used route is orotracheal, in which an endotracheal tube is passed through the mouth and vocal apparatus into the trachea. In a nasotracheal procedure, an endotracheal tube is passed through the nose and vocal apparatus into the trachea. Alternatives to standard endotracheal tubes include laryngeal tube and combitube.

Surgical methods

In cricothyrotomy, the incision or puncture is made through the cricothyroid membrane in between the thyroid cartilage and the cricoid cartilage
In cricothyrotomy, the incision or puncture is made through the cricothyroid membrane in between the thyroid cartilage and the cricoid cartilage
 
Photograph of a tracheostomy tube

Surgical methods for airway management rely on making a surgical incision below the glottis in order to achieve direct access to the lower respiratory tract, bypassing the upper respiratory tract. Surgical airway management is often performed as a last resort in cases where orotracheal and nasotracheal intubation are impossible or contraindicated. Surgical airway management is also used when a person will need a mechanical ventilator for a longer period. Surgical methods for airway management include cricothyrotomy and tracheostomy.

A cricothyrotomy is an emergency surgical procedure in which an incision is made through the cricothyroid membrane to establish a patent airway during certain life-threatening situations, such as airway obstruction by a foreign body, angioedema, or massive facial trauma. Cricothyrotomy is much easier and quicker to perform than tracheotomy, does not require manipulation of the cervical spine and is associated with fewer immediate complications. Some complications of cricothyrotomy include bleeding, infection, and injury to surrounding skin and soft tissue structures.

A tracheotomy is a surgical procedure in which a surgeon makes incision in the neck and a breathing tube is inserted directly into the trachea. A common reason for performing a tracheotomy includes requiring to be put on a mechanical ventilator for a longer period. The advantages of a tracheotomy include less risk of infection and damage to the trachea during the immediate post-surgical period. Although rare, some long term complications of tracheotomies include tracheal stenosis and tracheoinnominate fistulas.

Airway management in specific situations

Cardiopulmonary resuscitation

The optimal method of airway management during CPR is not well established at this time given that the majority of studies on the topic are observational in nature. These studies, however, guide recommendations until prospective, randomized controlled trials are conducted.

Current evidence suggests that for out-of-hospital cardiac arrest, basic airway interventions (head-tilt–chin-lift maneuvers, bag-valve-masking or mouth-to-mouth ventilations, nasopharyngeal and/or oropharyngeal airways) resulted in greater short-term and long-term survival, as well as improved neurological outcomes in comparison to advanced airway interventions (endotracheal intubation, laryngeal mask airway, all types of supraglottic airways (SGA), and trans-tracheal or trans-cricothyroid membrane airways). Given that these are observational studies, caution must be given to the possibility of confounding by indication. That is, patients requiring an advanced airway may have had a poorer prognosis in relation to those requiring basic interventions to begin with.

For the management of in-hospital cardiac arrest however, studies currently support the establishment of an advanced airway. It is well documented that quality chest compressions with minimal interruption result in improved survival. This is suggested to be due, in part, to decreased no-flow-time in which vital organs, including the heart are not adequately perfused. Establishment of an advanced airway (endotracheal tube, laryngeal mask airway) allows for asynchronous ventilation, reducing the no-flow ratio, as compared to the basic airway (bag-valve mask) for which compressions must be paused to adequately ventilate the patient.

Bystanders without medical training who see an individual suddenly collapse should call for help and begin chest compressions immediately. The American Heart Association currently supports "Hands-only"™ CPR, which advocates chest compressions without rescue breaths for teens or adults. This is to minimize the reluctance to start CPR due to concern for having to provide mouth-to-mouth resuscitation.

Trauma

Bag-valve mashttps://en.wikipedia.org/wiki/Airway_managementk ventilation. Airway represents the "A" in the ABC mnemonic for trauma resuscitation.

Management of the airway in trauma can be particularly complicated, and is dependent on the mechanism, location, and severity of injury to the airway and its surrounding tissues. Injuries to the cervical spine, traumatic disruption of the airway itself, edema in the setting of caustic or thermal trauma, and the combative patient are examples of scenarios a provider may need to take into account in assessing the urgency of securing an airway and the means of doing so.

The pre-hospital setting provides unique challenges to management of the airway including tight spaces, neck immobilization, poor lighting, and often the added complexity of attempting procedures during transport. When possible, basic airway management should be prioritized including head-tilt-chin-lift maneuvers, and bag-valve masking. If ineffective, a supraglottic airway can be utilized to aid in oxygenation and maintenance of a patent airway. An oropharyngeal airway is acceptable, however nasopharyngeal airways should be avoided in trauma, particularly if a basilar skull fracture is suspected. Endotracheal intubation carries with it many risks, particularly when paralytics are used, as maintenance of the airway becomes a challenge if intubation fails. It should therefore be attempted by experienced personnel, only when less invasive methods fail or when it is deemed necessary for safe transport of the patient, to reduce risk of failure and the associated increase in morbidity and mortality due to hypoxia.

Laryngeal mask airway (LMA). Example of a supraglottic device.

Management of the airway in the emergency department is optimal given the presence of trained personnel from multiple specialties, as well as access to "difficult airway equipment" (videolaryngoscopy, eschmann tracheal tube introducer, fiberoptic bronchoscopy, surgical methods, etc.). Of primary concern is the condition and patency of the maxillofacial structures, larynx, trachea, and bronchi as these are all components of the respiratory tract and failure anywhere along this path may impede ventilation. Excessive facial hair, severe burns, and maxillofacial trauma may prevent acquisition of a good mask seal, rendering bag-valve mask ventilation difficult. Edema of the airway can make laryngoscopy difficult, and therefore in those with suspected thermal burns, intubation is recommended in attempts to quickly secure an airway prior to progression of the swelling. Furthermore, blood and vomitus in the airway may prove visualization of the vocal cords difficult rendering direct and video laryngoscopy, as well as fiberoptic bronchoscopy challenging. Establishment of a surgical airway is challenging in the setting of restricted neck extension (such as in a c-collar), laryngotracheal disruption, or distortion of the anatomy by a penetrating force or hematoma. Tracheotomy in the operating room by trained professionals is recommended over cricothyroidotomy in the case of complete laryngotracheal disruption or children under the age of 12.

Mechanical ventilation

From Wikipedia, the free encyclopedia

Mechanical ventilation
Servo I Ventilator.jpg
Servo-u Ventilator
ICD-993.90 96.7
MeSHD012121
OPS-301 code8-71

Mechanical ventilation, assisted ventilation or intermittent mandatory ventilation (IMV), is the medical term for using a machine called a ventilator to fully or partially provide artificial ventilation. Mechanical ventilation helps move air into and out of the lungs, with the main goal of helping the delivery of oxygen and removal of carbon dioxide. Mechanical ventilation is used for many reasons, including to protect the airway due to mechanical or neurologic cause, to ensure adequate oxygenation, or to remove excess carbon dioxide from the lungs. Various healthcare providers are involved with the use of mechanical ventilation and people who require ventilators are typically monitored in an intensive care unit.

Mechanical ventilation is termed invasive if it involves an instrument to create an airway that is placed inside the trachea. This is done through an endotracheal tube or nasotracheal tube.

For non-invasive ventilation in people who are conscious, face or nasal masks are used.

The two main types of mechanical ventilation include positive pressure ventilation where air is pushed into the lungs through the airways, and negative pressure ventilation where air is pulled into the lungs. There are many specific modes of mechanical ventilation, and their nomenclature has been revised over the decades as the technology has continually developed.

History

Hospital staff examine a patient in an Iron lung tank respirator during the polio epidemic. The machine creates a negative pressure around the thoracic cavity, thereby causing air to rush into the lungs to equalize intrapulmonary pressure.

The Greek physician Galen may have been the first to describe mechanical ventilation: "If you take a dead animal and blow air through its larynx [through a reed], you will fill its bronchi and watch its lungs attain the greatest distention." In the 1600s, Robert Hooke conducted experiments on dogs to demonstrate this concept. Vesalius too describes ventilation by inserting a reed or cane into the trachea of animals. These experiments predate the discovery of oxygen and its role in respiration. In 1908, George Poe demonstrated his mechanical respirator by asphyxiating dogs and seemingly bringing them back to life. These experiments all demonstrate positive pressure ventilation.

To achieve negative pressure ventilation, there must be a sub-atmospheric pressure to draw air into the lungs. This was first achieved in the late 19th century when John Dalziel and Alfred Jones independently developed tank ventilators, in which ventilation was achieved by placing a patient inside a box that enclosed the body in a box with sub-atmospheric pressures. This machine came to be known colloquially as the Iron lung, which went through many iterations of development. The use of the iron lung became widespread during the polio epidemic of the 1900s.

Early ventilators were control style with no support breaths integrated into them and were limited to an inspiration to expiration ration of 1:1. In the 1970s, intermittent mandatory ventilation was introduced as well as synchronized intermittent mandatory ventilation. These styles of ventilation had control breaths that patients could breath between.

Uses

Respiratory therapist (RT) examining a mechanically ventilated patient in an intensive care unit. RTs participate in the optimization of ventilation management, adjustment, and weaning.

Mechanical ventilation is indicated when a patient's spontaneous breathing is inadequate to maintain life. It may be indicated in anticipation of imminent respiratory failure, acute respiratory failure, acute hypoxemia, or prophylactically. Because mechanical ventilation serves only to provide assistance for breathing and does not cure a disease, the patient's underlying condition should be identified and treated in order to liberate them from the ventilator.

Common specific medical indications for mechanical ventilation include:

Mechanical ventilation is typically used as a short-term measure. It may, however, be used at home or in a nursing or rehabilitation institution for patients that have chronic illnesses that require long-term ventilatory assistance.

Risks and complications

Mechanical ventilation is often a life-saving intervention, but carries potential complications. A common complication of positive pressure ventilation stemming directly from the ventilator settings include volutrauma and barotrauma. Others include pneumothorax, subcutaneous emphysema, pneumomediastinum, and pneumoperitoneum. Another well-documented complication is ventilator-associated lung injury which presents as acute respiratory distress syndrome. Other complications include diaphragm atrophy, decreased cardiac output, and oxygen toxicity. One of the primary complications that presents in patients mechanically ventilated is acute lung injury (ALI)/acute respiratory distress syndrome (ARDS). ALI/ARDS are recognized as significant contributors to patient morbidity and mortality.

In many healthcare systems, prolonged ventilation as part of intensive care is a limited resource. For this reason, decisions to commence and remove ventilation may raise ethical debate and often involve legal orders such as do-not-resuscitate orders.

Mechanical ventilation is often associated with many painful procedures and the ventilation itself can be uncomfortable. For infants who require opioids for pain, the potential side effects of opioids include problems with feeding, gastric and intestinal mobility problems, the potential for opioid dependence, and opioid tolerance.

Withdrawal from mechanical ventilation

Timing of withdrawal from mechanical ventilation—also known as weaning—is an important consideration. People who require mechanical ventilation should have their ventilation considered for withdrawal if they are able to support their own ventilation and oxygenation, and this should be assessed continuously. There are several objective parameters to look for when considering withdrawal, but there are no specific criteria that generalizes to all patients.

The Rapid Shallow Breathing Index (RSBI, the ratio of respiratory frequency to tidal volume (f/VT), previously referred to as the "Yang Tobin Index" or "Tobin Index" after Dr. Karl Yang and Prof. Martin J. Tobin of Loyola University Medical Center) is one of the best studied and most commonly used weaning predictors, with no other predictor having been shown to be superior. It was described in a prospective cohort study of mechanically ventilated patients which found that a RSBI > 105 breaths/min/L was associated with weaning failure, while a RSBI < 105 breaths/min/L.

Spontaneous breathing trials are conducted to assess the likelihood of a patient being able to maintain stability and breath on their own without the ventilator. This is done by changing the mode to one where they have to trigger breaths and ventilatory support is only given to compensate for the added resistance of the endotracheal tube.

A cuff leak test is done to detect if there is airway edema to show the chances of post-extubation stridor. This is done by deflating to the cuff to check if air begins leaking around the endotracheal tube.

Physiology

The function of the lungs is to provide gas exchange via oxygenation and ventilation. This phenomenon of respiration involves the physiologic concepts of air flow, tidal volume, compliance, resistance, and dead space. Other relevant concepts include alveolar ventilation, arterial PaCO2, alveolar volume, and FiO2. Alveolar ventilation is the amount of gas per unit of time that reaches the alveoli and becomes involved in gas exchange. PaCO2 is the partial pressure of carbon dioxide of arterial blood, which determines how well carbon dioxide is able to move out of the body. Alveolar volume is the volume of air entering and leaving the alveoli per minute. Mechanical dead space is another important parameter in ventilator design and function, and is defined as the volume of gas breathed again as the result of use in a mechanical device.

Image of endotracheal tube placement required to connect a patient's physiologic airway to the ventilator.

Due to the anatomy of the human pharynx, larynx, and esophagus and the circumstances for which ventilation is needed, additional measures are required to secure the airway during positive-pressure ventilation in order to allow unimpeded passage of air into the trachea and avoid air passing into the esophagus and stomach. The common method is by insertion of a tube into the trachea. Intubation, which provides a clear route for the air can be either an endotracheal tube, inserted through the natural openings of mouth or nose, or a tracheostomy inserted through an artificial opening in the neck. In other circumstances simple airway maneuvers, an oropharyngeal airway or laryngeal mask airway may be employed. If non-invasive ventilation or negative-pressure ventilation is used, then an airway adjunct is not needed.

Pain medicine such as opioids are sometimes used in adults and infants who require mechanical ventilation. For preterm or full term infants who require mechanical ventilation, there is no strong evidence to prescribe opioids or sedation routinely for these procedures, however, some select infants requiring mechanical ventilation may require pain medicine such as opioids. It is not clear if clonidine is safe or effective to be used as a sedative for preterm and full term infants who require mechanical ventilation.

When 100% oxygen (1.00 FiO
2
) is used initially for an adult, it is easy to calculate the next FiO
2
to be used, and easy to estimate the shunt fraction. The estimated shunt fraction refers to the amount of oxygen not being absorbed into the circulation. In normal physiology, gas exchange of oxygen and carbon dioxide occurs at the level of the alveoli in the lungs. The existence of a shunt refers to any process that hinders this gas exchange, leading to wasted oxygen inspired and the flow of un-oxygenated blood back to the left heart, which ultimately supplies the rest of the body with de-oxygenated blood. When using 100% oxygen, the degree of shunting is estimated as 700 mmHg - measured PaO
2
. For each difference of 100 mmHg, the shunt is 5%. A shunt of more than 25% should prompt a search for the cause of this hypoxemia, such as mainstem intubation or pneumothorax, and should be treated accordingly. If such complications are not present, other causes must be sought after, and positive end-expiratory pressure (PEEP) should be used to treat this intrapulmonary shunt. Other such causes of a shunt include:

Technique

Modes

Mechanical ventilation utilizes several separate systems for ventilation referred to as the mode. Modes come in many different delivery concepts but all conventional positive pressure ventilators modes fall into one of two categories; volume-cycled or pressure-cycled. A relatively new ventilation mode is flow-controlled ventilation (FCV). FCV is a fully dynamic mode without significant periods of 'no flow'. It is based on creating a stable gas flow into or out of the patient’s lungs to generate an inspiration or expiration, respectively. This results in linear increases and decreases in intratracheal pressure. In contrast to conventional modes of ventilation, there are no abrupt drop intrathoracic pressure drops, because of the controlled expiration. Further, this mode allows to use thin endotracheal tubes (~2 - 10 mm inner diameter) to ventilate a patient as expiration is actively supported. In general, the selection of which mode of mechanical ventilation to use for a given patient is based on the familiarity of clinicians with modes and the equipment availability at a particular institution.

Types of Ventilation

Carl Gunnar Engström invented in 1950 one of the first intermittent positive pressure ventilator, which delivers air straight into the lungs using an endotracheal tube placed into the windpipe.

Positive pressure

The design of the modern positive-pressure ventilators were based mainly on technical developments by the military during World War II to supply oxygen to fighter pilots in high altitude. Such ventilators replaced the iron lungs as safe endotracheal tubes with high-volume/low-pressure cuffs were developed. The popularity of positive-pressure ventilators rose during the polio epidemic in the 1950s in Scandinavia and the United States and was the beginning of modern ventilation therapy. Positive pressure through manual supply of 50% oxygen through a tracheostomy tube led to a reduced mortality rate among patients with polio and respiratory paralysis. However, because of the sheer amount of man-power required for such manual intervention, mechanical positive-pressure ventilators became increasingly popular.

Positive-pressure ventilators work by increasing the patient's airway pressure through an endotracheal or tracheostomy tube. The positive pressure allows air to flow into the airway until the ventilator breath is terminated. Then, the airway pressure drops to zero, and the elastic recoil of the chest wall and lungs push the tidal volume — the breath-out through passive exhalation.

Negative pressure

Negative pressure mechanical ventilators are produced in small, field-type and larger formats. The prominent design of the smaller devices is known as the cuirass, a shell-like unit used to create negative pressure only to the chest using a combination of a fitting shell and a soft bladder. In recent years this device has been manufactured using various-sized polycarbonate shells with multiple seals, and a high-pressure oscillation pump in order to carry out biphasic cuirass ventilation. Its main use has been in patients with neuromuscular disorders that have some residual muscular function. The latter, larger formats are in use, notably with the polio wing hospitals in England such as St Thomas' Hospital in London and the John Radcliffe in Oxford.

The larger units have their origin in the iron lung, also known as the Drinker and Shaw tank, which was developed in 1928 by J.H Emerson Company and was one of the first negative-pressure machines used for long-term ventilation. It was refined and used in the 20th century largely as a result of the polio epidemic that struck the world in the 1940s. The machine is, in effect, a large elongated tank, which encases the patient up to the neck. The neck is sealed with a rubber gasket so that the patient's face (and airway) are exposed to the room air. While the exchange of oxygen and carbon dioxide between the bloodstream and the pulmonary airspace works by diffusion and requires no external work, air must be moved into and out of the lungs to make it available to the gas exchange process. In spontaneous breathing, a negative pressure is created in the pleural cavity by the muscles of respiration, and the resulting gradient between the atmospheric pressure and the pressure inside the thorax generates a flow of air. In the iron lung by means of a pump, the air is withdrawn mechanically to produce a vacuum inside the tank, thus creating negative pressure. This negative pressure leads to expansion of the chest, which causes a decrease in intrapulmonary pressure, and increases flow of ambient air into the lungs. As the vacuum is released, the pressure inside the tank equalizes to that of the ambient pressure, and the elastic recoil of the chest and lungs leads to passive exhalation. However, when the vacuum is created, the abdomen also expands along with the lung, cutting off venous flow back to the heart, leading to pooling of venous blood in the lower extremities. The patients can talk and eat normally, and can see the world through a well-placed series of mirrors. Some could remain in these iron lungs for years at a time quite successfully.

Some of the problems with the full body design were such as being unable to control the inspiratory to expiratory ratio and the flow rate. This design also caused blood pooling in the legs.

Intermittent abdominal pressure ventilator

Another type is the intermittent abdominal pressure ventilator that applies pressure externally via an inflated bladder, forcing exhalation, sometimes termed exsufflation. The first such apparatus was the Bragg-Paul Pulsator. The name of one such device, the Pneumobelt made by Puritan Bennett has to a degree become a generic name for the type.

Oscillator

3100A Oscillator

The most commonly used high frequency ventilator and only one approved in the United States is the 3100A from Vyaire Medical. It works by using very small tidal volumes by setting amplitude and a high rate set in hertz. This type of ventilation is primarily used in neonates and pediatric patients who are failing conventional ventilation.

High Frequency Jet Ventilation

The first type of high frequency ventilator made for neonates and the only jet type is made by Bunnell Incorporated. It works in conjunction with a separate CMV ventilator to add pulses of air to the control breaths and PEEP.

Neonatal Jet ventilator

Monitoring

One of the main reasons why a patient is admitted to an ICU is for delivery of mechanical ventilation. Monitoring a patient in mechanical ventilation has many clinical applications: Enhance understanding of pathophysiology, aid with diagnosis, guide patient management, avoid complications, and assess trends.

In ventilated patients, pulse oximetry is commonly used when titrating FIO2. A reliable target of Spo2 is greater than 95%.

The total PEEP in the patient can be determined by doing an expiratory hold on the ventilator. If this is higher than the set PEEP, this indicates air trapping.

The plateau pressure can be found by doing an inspiratory hold. This shows the actual pressure the patient's lungs are experiencing.

Loops can be used to see what is occurring in the patient's lungs. These include flow-volume and pressure-volume loops. They can show changes in compliance and resistance.

Functional Residual Capacity can be determined when using the GE Carestation.

Modern ventilators have advanced monitoring tools. There are also monitors that work independently of the ventilator which allow for measuring patients after the ventilator has been removed, such as a Tracheal tube test.

Types of ventilators

SMART BAG MO Bag-Valve-Mask Resuscitator

Ventilators come in many different styles and method of giving a breath to sustain life. There are manual ventilators such as bag valve masks and anesthesia bags that require the users to hold the ventilator to the face or to an artificial airway and maintain breaths with their hands. Mechanical ventilators are ventilators not requiring operator effort and are typically computer-controlled or pneumatic-controlled. Mechanical ventilators typically require power by a battery or a wall outlet (DC or AC) though some ventilators work on a pneumatic system not requiring power. There are a variety of technologies available for ventilation, falling into two main (and then lesser categories), the two being the older technology of negative-pressure mechanisms, and the more common positive-pressure types.

Common positive-pressure mechanical ventilators include:

  1. Transport ventilators—These ventilators are small and more rugged, and can be powered pneumatically or via AC or DC power sources.
  2. Intensive-care ventilators—These ventilators are larger and usually run on AC power (though virtually all contain a battery to facilitate intra-facility transport and as a back-up in the event of a power failure). This style of ventilator often provides greater control of a wide variety of ventilation parameters (such as inspiratory rise time). Many ICU ventilators also incorporate graphics to provide visual feedback of each breath.
  3. Neonatal ventilators (bubble CPAP, HFJV, HFOV)—Designed with the preterm neonate in mind, these are a specialized subset of ICU ventilators that are designed to deliver smaller volumes and pressures to these patients. These may be conventional or high frequency types.
  4. Positive airway pressure ventilators (PAP) — These ventilators are specifically designed for non-invasive ventilation. This includes ventilators for use at home for treatment of chronic conditions such as sleep apnea or COPD and in the ICU setting.

Breath delivery mechanisms

Trigger

The trigger, either flow or pressure, is what causes a breath to be delivered by a mechanical ventilator. Breaths may be triggered by a patient taking their own breath, a ventilator operator pressing a manual breath button, or based on the set respiratory rate.

Cycle

The cycle is what causes the breath to transition from the inspiratory phase to the exhalation phase. Breaths may be cycled by a mechanical ventilator when a set time has been reached, or when a preset flow or percentage of the maximum flow delivered during a breath is reached depending on the breath type and the settings. Breaths can also be cycled when an alarm condition such as a high pressure limit has been reached.

Limit

Limit is how the breath is controlled. Breaths may be limited to a set maximum pressure or volume.

Breath exhalation

Exhalation in mechanical ventilation is almost always completely passive. The ventilator's expiratory valve is opened, and expiratory flow is allowed until the baseline pressure (PEEP) is reached. Expiratory flow is determined by patient factors such as compliance and resistance.

Artificial airways as a connection to the ventilator

There are various procedures and mechanical devices that provide protection against airway collapse, air leakage, and aspiration:

  • Face mask — In resuscitation and for minor procedures under anaesthesia, a face mask is often sufficient to achieve a seal against air leakage. Airway patency of the unconscious patient is maintained either by manipulation of the jaw or by the use of nasopharyngeal or oropharyngeal airway. These are designed to provide a passage of air to the pharynx through the nose or mouth, respectively. Poorly fitted masks often cause nasal bridge ulcers, a problem for some patients. Face masks are also used for non-invasive ventilation in conscious patients. A full-face mask does not, however, provide protection against aspiration. Non-invasive ventilation can be considered for epidemics of COVID-19 where sufficient invasive ventilation capacity is not available (or in some milder cases), but pressurized protection suits for caregivers are recommended due to the risks of poorly fitting masks emitting contaminating aerosols.
  • Tracheal intubation is often performed for mechanical ventilation of hours to weeks duration. A tube is inserted through the nose (nasotracheal intubation) or mouth (orotracheal intubation) and advanced into the trachea. In most cases, tubes with inflatable cuffs are used for protection against leakage and aspiration. Intubation with a cuffed tube is thought to provide the best protection against aspiration. Tracheal tubes inevitably cause pain and coughing. Therefore, unless a patient is unconscious or anaesthetized for other reasons, sedative drugs are usually given to provide tolerance of the tube. Other disadvantages of tracheal intubation include damage to the mucosal lining of the nasopharynx or oropharynx and subglottic stenosis.
  • Supraglottic airway — a supraglottic airway (SGA) is any airway device that is seated above and outside the trachea, as an alternative to endotracheal intubation. Most devices work via masks or cuffs that inflate to isolate the trachea for oxygen delivery. Newer devices feature esophageal ports for suctioning or ports for tube exchange to allow intubation. Supraglottic airways differ primarily from tracheal intubation in that they do not prevent aspiration. After the introduction of the laryngeal mask airway (LMA) in 1998, supraglottic airway devices have become mainstream in both elective and emergency anesthesia. There are many types of SGAs available including the esophageal-tracheal combitube (ETC), laryngeal tube (LT), and the obsolete esophageal obturator airway (EOA).
  • Cricothyrotomy — Patients requiring emergency airway management, in whom tracheal intubation has been unsuccessful, may require an airway inserted through a surgical opening in the cricothyroid membrane. This is similar to a tracheostomy but a cricothyrotomy is reserved for emergency access.
  • Tracheostomy — When patients require mechanical ventilation for several weeks, a tracheostomy may provide the most suitable access to the trachea. A tracheostomy is a surgically created passage into the trachea. Tracheostomy tubes are well tolerated and often do not necessitate any use of sedative drugs. Tracheostomy tubes may be inserted early during treatment in patients with pre-existing severe respiratory disease, or in any patient expected to be difficult to wean from mechanical ventilation, i.e., patients with little muscular reserve.
  • Mouthpiece — Less common interface, does not provide protection against aspiration. There are lipseal mouthpieces with flanges to help hold them in place if patient is unable.

Wednesday, February 22, 2023

Iron lung

From Wikipedia, the free encyclopedia
Iron lung
Iron lung CDC.jpg
An Emerson iron lung
ICD-9-CM93.99
MeSHD015919

An iron lung is a type of negative pressure ventilator (NPV), a mechanical respirator which encloses most of a person's body, and varies the air pressure in the enclosed space, to stimulate breathing. It assists breathing when muscle control is lost, or the work of breathing exceeds the person's ability. Need for this treatment may result from diseases including polio and botulism and certain poisons (for example, barbiturates, tubocurarine).

The use of iron lungs is largely obsolete in modern medicine, as more modern breathing therapies have been developed, and due to the eradication of polio in most of the world. However, in 2020, the COVID-19 pandemic revived some interest in the device as a cheap, readily-producible substitute for positive-pressure ventilators, which were feared to be outnumbered by patients potentially needing temporary artificially assisted respiration.

Design and function

Iron lung cylinder (black), patient head exposed through sealed opening. Diaphragm (yellow) mechanically extends/retracts, varying cylinder air pressure, causing patient chest to expand (inhale) (top) and contract (exhaling) (bottom)

The iron lung is typically a large horizontal cylinder, in which a person is laid, with their head protruding from a hole in the end of the cylinder, so that their full head (down to their voice box) is outside the cylinder, exposed to ambient air, and the rest of their body sealed inside the cylinder, where air pressure is continuously cycled up and down, to stimulate breathing.

To cause the patient to inhale, air is pumped out of the cylinder, causing a slight vacuum, which causes the patient's chest and abdomen to expand (drawing air from outside the cylinder, through the patient's exposed nose or mouth, into their lungs). Then, for the patient to exhale, the air inside the cylinder is compressed slightly (or allowed to equalize to ambient room pressure), causing the patient's chest and abdomen to partially collapse, forcing air out of the lungs, as the patient exhales the breath through their exposed mouth and nose, outside the cylinder.

Examples of the device include the Drinker respirator, the Emerson respirator, and the Both respirator. Iron lungs can be either manually or mechanically powered but normally are powered by an electric motor linked to a flexible pumping diaphragm (commonly opposite the end of the cylinder from the patient's head). Larger "room-sized" iron lungs were also developed, allowing for simultaneous ventilation of several patients (each with their heads protruding from sealed openings in the outer wall), with sufficient space inside for a nurse or a respiratory therapist to be inside the sealed room, attending the patients.

Smaller, single-patient versions of the iron lung include the so-called cuirass ventilator (named for the cuirass, a torso-covering body armor). The cuirass ventilator encloses only the patient's torso, or chest and abdomen, but otherwise operates essentially the same as the original, full-sized iron lung. A lightweight variation on the cuirass ventilator is the jacket ventilator or poncho or raincoat ventilator, which uses a flexible, impermeable material (such as plastic or rubber) stretched over a metal or plastic frame over the patient's torso.

Method and use

An Iron Lung ward, as mocked-up for a film, circa 1953

Humans, like most mammals, breathe by negative pressure breathing: the rib cage expands and the diaphragm contracts, expanding the chest cavity. This causes the pressure in the chest cavity to decrease, and the lungs expand to fill the space. This, in turn, causes the pressure of the air inside the lungs to decrease (it becomes negative, relative to the atmosphere), and air flows into the lungs from the atmosphere: inhalation. When the diaphragm relaxes, the reverse happens and the person exhales. If a person loses part or all of the ability to control the muscles involved, breathing becomes difficult or impossible.

Invention and early use

Initial development

Iron lung from the 1950s in the Gütersloh Town Museum. In Germany, fewer than a dozen of these breathing machines are available to the public.

In 1670, English scientist John Mayow came up with the idea of external negative pressure ventilation. Mayow built a model consisting of bellows and a bladder to pull in and expel air. The first negative pressure ventilator was described by British physician John Dalziel in 1832. Successful use of similar devices was described a few years later. Early prototypes included a hand-operated bellows-driven "Spirophore" designed by Dr Woillez of Paris (1876), and an airtight wooden box designed specifically for the treatment of polio by Dr Stueart of South Africa (1918). Stueart's box was sealed at the waist and shoulders with clay and powered by motor-driven bellows.

Drinker and Shaw tank

A Drinker iron lung displayed at the chapel of Netley Hospital, 2018

The first of these devices to be widely used however was developed in 1928 by Drinker and Shaw of the United States. The iron lung, often referred to in the early days as the "Drinker respirator", was invented by Philip Drinker (1894–1972) and Louis Agassiz Shaw Jr., professors of industrial hygiene at the Harvard School of Public Health. The machine was powered by an electric motor with air pumps from two vacuum cleaners. The air pumps changed the pressure inside a rectangular, airtight metal box, pulling air in and out of the lungs. The first clinical use of the Drinker respirator on a human was on October 12, 1928, at the Boston Children's Hospital in the US. The subject was an eight-year-old girl who was nearly dead as a result of respiratory failure due to polio. Her dramatic recovery, within less than a minute of being placed in the chamber, helped popularize the new device.

Variations

Boston manufacturer Warren E. Collins began production of the iron lung that year. Although it was initially developed for the treatment of victims of coal gas poisoning, it was most famously used in the mid-20th century for the treatment of respiratory failure caused by poliomyelitis.

Danish physiologist August Krogh, upon returning to Copenhagen in 1931 from a visit to New York where he saw the Drinker machine in use, constructed the first Danish respirator designed for clinical purposes. Krogh's device differed from Drinker's in that its motor was powered by water from the city pipelines. Krogh also made an infant respirator version.

In 1931, John Haven Emerson (1906–1997) introduced an improved and less expensive iron lung. The Emerson iron lung had a bed that could slide in and out of the cylinder as needed, and the tank had portal windows which allowed attendants to reach in and adjust limbs, sheets, or hot packs. Drinker and Harvard University sued Emerson, claiming he had infringed on patent rights. Emerson defended himself by making the case that such lifesaving devices should be freely available to all. Emerson also demonstrated that every aspect of Drinker's patents had been published or used by others at earlier times. Since an invention must be novel to be patentable, prior publication/use of the invention meant it was not novel and therefore unpatentable. Emerson won the case, and Drinker's patents were declared invalid.

The United Kingdom's first iron lung was designed in 1934 by Robert Henderson, an Aberdeen doctor. Henderson had seen a demonstration of the Drinker respirator in the early 1930s and built a device of his own upon his return to Scotland. Four weeks after its construction, the Henderson respirator was used to save the life of a 10-year-old boy from New Deer, Aberdeenshire, who had poliomyelitis. Despite this success, Henderson was reprimanded for secretly using hospital facilities to build the machine.

Both respirator

A Both cabinet respirator being used to treat a patient at the 110th Australian Military Hospital in 1943
 

The Both respirator, a negative pressure ventilator, was invented in 1937 when Australia's epidemic of poliomyelitis created an immediate need for more ventilating machines to compensate for respiratory paralysis. Although the Drinker model was effective and saved lives, its widespread use was hindered by the fact that the machines were very large, heavy (about 750 lbs or 340 kg), bulky, and expensive. In the US, an adult machine cost about $2000 in 1930, and £2000 delivered to Melbourne in 1936. The cost in Europe in the mid-1950s was around £1500. Consequently, there were few of the Drinker devices in Australia and Europe.

The South Australia Health Department asked Adelaide brothers Edward and Don Both to create an inexpensive "iron lung". Biomedical engineer Edward Both designed and developed a cabinet respirator made of plywood that worked similarly to the Drinker device, with the addition of a bi-valved design which allowed temporary access to the patient's body. Far cheaper to make (only £100) than the Drinker machine, the Both Respirator also weighed less and could be constructed and transported more quickly. Such was the demand for the machines that they were often used by patients within an hour of production.

Both-Nuffield iron lung display at the Thackray Medical Museum, Leeds. Pictures show assembly at the Morris motor works

Visiting London in 1938 during another polio epidemic, Both produced additional respirators there which attracted the attention of William Morris (Lord Nuffield), a British motor manufacturer and philanthropist. Nuffield, intrigued by the design, financed the production of approximately 1700 machines at his car factory in Cowley, and donated them to hospitals throughout all parts of Britain and the British Empire. Soon, the Both-Nuffield respirators were able to be produced by the thousand at about one-thirteenth the cost of the American design. By the early 1950s, there were over 700 Both-Nuffield iron lungs in the United Kingdom, but only 50 Drinker devices.

Polio epidemic

Staff in a Rhode Island hospital examine a patient in an iron lung tank respirator during a polio epidemic in Rhode Island in 1960. The iron lung encased the thoracic cavity in an air-tight chamber used to create negative pressure around the thoracic cavity, thereby causing air to enter the lungs to equalize intrapulmonary pressure.

Rows of iron lungs filled hospital wards at the height of the polio outbreaks of the 1940s and 1950s, helping children, and some adults, with bulbar polio and bulbospinal polio. A polio patient with a paralyzed diaphragm would typically spend two weeks inside an iron lung while recovering.

Modern development and usage

Polio vaccination programs have virtually eradicated new cases of poliomyelitis in the developed world. Because of this, and the development of modern ventilators, and widespread use of tracheal intubation and tracheotomy, the iron lung has mostly disappeared from modern medicine. In 1959, 1,200 people were using tank respirators in the United States, but by 2004 that number had decreased to just 39.

By 2014, only 10 people were left with an iron lung.

Replacement

Positive pressure ventilation systems are now more common than negative pressure systems. Positive pressure ventilators work by blowing air into the patient's lungs via intubation through the airway; they were used for the first time in Blegdams Hospital, Copenhagen, Denmark, during a polio outbreak in 1952. It proved a success and soon superseded the iron lung throughout Europe.

The iron lung now has a marginal place in modern respiratory therapy. Most patients with paralysis of the breathing muscles use modern mechanical ventilators that push air into the airway with positive pressure. These are generally efficacious and have the advantage of not restricting patients' movements or caregivers' ability to examine the patients as significantly as an iron lung does.

Continued use

Despite the advantages of positive ventilation systems, negative pressure ventilation is a truer approximation of normal physiological breathing and results in a more normal distribution of air in the lungs. It may also be preferable in certain rare conditions, such as central hypoventilation syndrome, in which failure of the medullary respiratory centers at the base of the brain results in patients having no autonomic control of breathing. At least one reported polio patient, Dianne Odell, had a spinal deformity that caused the use of mechanical ventilators to be contraindicated.

At least a few patients today still use the older machines, often in their homes, despite the occasional difficulty of finding replacement parts.

Joan Headley of Post-Polio Health International said that as of May 28, 2008, about 30 patients in the U.S. were still using an iron lung. That figure may be inaccurately low; Houston alone had 19 iron lung patients living at home in 2008.

Martha Mason of Lattimore, North Carolina died on May 4, 2009, after spending 60 of her 72 years in an iron lung.

On October 30, 2009, June Middleton of Melbourne, Australia, who had been entered in the Guinness Book of Records as the person who spent the longest time in an iron lung, died aged 83, having spent more than 60 years in her iron lung.

In 2013, the Post-Polio Health International (PHI) organizations estimated that only six to eight iron lung users were in the United States; as of 2017 its executive director knew of none. Press reports then emerged, however, of at least three (perhaps the last three) users of such devices, sparking interest amongst those in the makerspace community such as Naomi Wu in the manufacture of the obsolete components, particularly the gaskets. One is retired lawyer Paul Alexander, 77, of Dallas.

In 2021, the National Public Radio programs Radio Diaries and All Things Considered gave a report on Martha Lillard, one of the last two Americans depending on the daily use of an iron lung, which she had been using since 1953. In her audio interview, she reported that she was having problems obtaining replacement parts to keep her machine working properly.

COVID-19 pandemic

In early 2020, reacting to the COVID-19 pandemic, to address the urgent global shortage of modern ventilators (needed for patients with advanced, severe COVID-19), some enterprises developed prototypes of new, readily-producible versions of the iron lung. These developments included:

Lie point symmetry

From Wikipedia, the free encyclopedia https://en.wikipedia.org/wiki/Lie_point_symmetry     ...