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Saturday, May 1, 2021

Inequality in disease

From Wikipedia, the free encyclopedia

Social epidemiology focuses on the patterns in morbidity and mortality rates that emerge as a result of social characteristics. While an individual's lifestyle choices or family history may place him or her at an increased risk for developing certain illnesses, there are social inequalities in health that cannot be explained by individual factors. Variations in health outcomes in the United States are attributed to several social characteristics, such as gender, race, socioeconomic status, the environment, and educational attainment. Inequalities in any or all of these social categories can contribute to health disparities, with some groups placed at an increased risk for acquiring chronic diseases than others.

For example, cardiovascular disease is the leading cause of death in the United States, followed closely by cancer, with the fifth most deadly being diabetes. The general risk factors associated with these diseases include obesity and poor diet, tobacco and alcohol use, physical inactivity, and access to medical care and health information. Although it may seem that many of these risk factors arise solely from individual health choices, such a view neglects the structural patterns in the choices that individuals make. Consequently, a person's likelihood of developing heart disease, cancer, or diabetes is in part correlated with social factors. Among all racial groups, individuals who are impoverished or low income, have lower levels of educational attainment, and/or live in lower-income neighborhoods are all more likely to develop chronic diseases, such as heart disease, cancer, and diabetes.

Gender

In the United States and Europe, up until the 19th century, women tended to die at an earlier age than men. This was largely due to the risks involved in pregnancy and childbirth. However, in the late 19th century there was a shift in life expectancy and women started to live longer than men. Notably, this is partly explained by biological factors. For instance, there is a cross-cultural trend that male fetal mortality rates are higher than female fetal mortality rates. Additionally, estrogen decreases the risk of females acquiring heart disease by lowering the amount of cholesterol in the blood, while testosterone suppresses the immune system in males and puts them at risk for acquiring serious illnesses. However, biological differences do not fully account for the large gender gap in the health outcomes of men and women. Social factors play a large role in gender disparities in health.

One of the main factors that contributes to the decreased life expectancy of males is their propensity to engage in risk-taking behaviors. Some commonly cited examples include heavy drinking, illicit drug use, violence, drunk driving, not wearing helmets, and smoking. These behaviors contribute to injuries that may lead to premature death in males. In particular, the effect of risk-taking behavior on health is especially visible in the case of smoking. As smoking rates have fallen in the United States overall, less men engage in this behavior and the life expectancy gap between men and women has slightly decreased as a result.

The behaviour of men and women also vary in regards to diet and exercise, leading to differential health outcomes . On average, men exercise more than women, but their diet is less nutritious. Consequently, men are more likely to be overweight, while women are at greater risk for obesity. Exposure to violence is another social factor that has an influence on health. In general, women have a higher likelihood of experiencing sexual and intimate partner violence, while men are twice as likely to die from suicide or homicide.

Markedly, the impact of gender on health becomes especially salient in different socioeconomic contexts. In the United States, there is a large economic gender inequality with many economically disadvantaged women occupying much fewer positions of power than men. According to the Panel Study of Income Dynamics, "among adults with the strongest attachment to the labor force, only 9.6% of women earned more than $50,000 annually, compared with 44.5% of men."  This gendered economic inequality is partly responsible for the gender-health paradox: the general trend that women live longer than men, but experience a greater degree of non-life-threatening chronic illnesses over the course of a lifetime. A low socioeconomic status in women contributes to feelings of a lack of personal control over the events in their lives, increased stress, and low self-esteem. Perpetual states of stress inflict damage on the bodies and minds of women, placing them at risk for physical ailments, such as heart disease and arthritis, as well mental health disorders, such as depression.

Another significant social factor is that men and women deal with their illnesses in different ways. Women generally have strong support networks and are able to rely on others for emotional support, with the potential to improve their states of health. In contrast, men are less likely to have strong support networks, they have fewer doctor visits, and often cope with their illnesses on their own. Also, men and women express pain in different ways. Researchers have observed that women openly express feelings of pain, while men are more reserved in this regard and prefer to appear tough even when they experience severe mental or physical suffering. This finding suggests that this is due to socialization processes. Women are taught to be submissive and emotional, while men are taught to be strong, powerful figures that do not show their emotions. The social stigma associated with expressions of pain prevents men from admitting their suffering to others, making it more difficult to overcome the pain.

Moreover, neighborhood effects have a greater influence on women than men. For instance, research findings suggest that women living in impoverished neighborhoods are more likely to experience obesity, while this effect is not as strong for men. The physical environment also generally impacts a woman's self-rated health. This effect can be explained by the fact that women spend more time at home than their male counterparts, as a result of higher unemployment rates, and therefore may be more exposed to negative environmental characteristics that take a toll on their health.

Finally, gender effects also vary with race, ethnicity, and nativity status. Notably, Christy Erving conducted a study in which she examined the gender differences in the health profiles of African Americans and Caribbean blacks (immigrants and U.S. born). One of the findings from this research is that on average, African American women report lower self-rated measures of health, worse physical health, and were more likely to experience severe chronic illnesses than men. This finding contradicts the gender-health paradox in the sense that researchers would expect morbidity rates to be higher for women, but less of the illnesses that they acquire should be debilitating. In contrast, the opposite trend is observed for U.S. born Caribbean blacks, with men more likely to experience chronic, life-threatening illnesses than women. The health outcomes of Caribbean black immigrants are somewhere in-between the health outcomes of U.S. born Caribbean blacks and African Americans, wherein the females have a lower value of self-reported health but experience equal rates of life-threatening, chronic disease as men. This data illustrates that even within one racial category, there can be stark gender differences in health on the basis of social differences within the groups that compose the race.

Race

Studies have shown that individuals that are racially and ethnically stigmatized, not just in the U.S., but globally as well, experience health issues such as mental and physical illness, and in some cases even death, in higher rates than the average individual. There has been some controversy around "race" being a determinant of disease and health issues, since there are unmeasured forms of background history that are potential factors in this research. Geographical origins and the types of environments individual races were exposed to are huge contributes to the health of a certain race, especially when the environment that they are in now is not the same as the one their race originates from geographically.

Along with these factors, physical, psychological, social, and chemical environments are all included and accounted for. Including exposure over the course of one's life and through generations, and biological adaptation to these environmental exposures, including gene expression. An example of this is a study of hypertension between black people and whites. West Africans and people of West African descent levels of hypertension increased when they moved from Africa to the United States. Their levels of hypertension were twice as high as the levels of black people that were in Africa. While whites in the United States even had higher rates of hypertension than Black people in Africa, the black people in the United States rates of hypertension were higher than some predominately white populations in Europe. Again, this proves that when a race is taken out of their original geographic environment, they are more prone to disease and illness, because their genetic make-up was made for a specific type of environment.

Transitioning from the environmental aspect of race and disease, there is a direct correlation between race and socioeconomic status which contributes to racial disparities in health. When it comes to death rates from heart disease, the rate is about twice as high for black men vs. white men. Now, death rates from heart disease are lower for both black and white women compared to their male counterparts, but the patterns of racial disparities and education disparities for women are similar to that of the men. Death from heart disease is about three times as higher for black women than white women. For both black men and women, racial differences in deaths from heart disease at every level of education is evident, with the racial gap being larger at the higher levels of education than at the lowest levels. There are a number of reasons why race matters in terms of health after socioeconomic status has been accounted for. For one, health is affected by adversity early on in one's life, such as traumatic stress, poverty, and abuse. These factors affect the physical and mental health of an individual. As we know, most of the people living in poverty in the United States are minorities, specifically African Americans, so unfortunately there is no surprise that they are the individuals with so many health issues.

Continuously, race is relevant to health issues, because of the non-equivalence of socioeconomic status indicators across racial groups. At the same level of education, minorities (black people and non-white Hispanic people) receive less income than their Anglo-white counterparts, as well as have less wealth and purchasing power. Namely, one of the biggest reasons that race matters in terms of health is due to racism. Both personal and institutionalized racism are very prominent in today's society, maybe not as blunt and easy to notice in comparison to the past, but it still exists. Certain residential segregation by race, such as redlining, has created very distinct racial differences in terms of education, employment, and opportunities. Opportunities such as access to good healthcare/medical care. Institutional and cultural racism can even harm minorities health through stereotypes and prejudices, which contributes to socioeconomic mobility and can reduce and limit resources and opportunities required for a healthy lifestyle.

Socioeconomic status is only one part of racial disparities in health that reflect larger social inequalities in society. Racism is a system that combines with, and sometimes changes, socioeconomic status to influence health, and race still matters for health when socioeconomic status is considered.

Socioeconomic status

Socioeconomic status is a multidimensional classification, often defined using an individual's income and level of education. Other related metrics can round out this definition; for example, in a 2006 study by authors Cox, McKevitt, Rudd and Wolfe, further categories included "occupation, home and goods ownership, and area-based deprivation indices" in their determination of status.

Income inequality has risen rapidly in the United States, pushing greater amounts of the population into positions of lower socioeconomic status. A study published in 1993 examined Americans who had passed away between May and August 1960, and paired the mortality information with income, education and occupation data for each person. The work found an inverse correlation between socioeconomic status and mortality rate, as well as an increasing strength of this pattern and its reflection of the growth of income inequality in the United States.

These findings, although concerned with total mortality of any cause, reflect a similar relationship between socioeconomic status and disease incidence or death in the United States. Disease composes a very significant portion of U.S. mortality; as of May 2017, 6 out of 7 of the leading causes of death in America are non-communicable diseases, including heart disease, cancer, lower respiratory diseases, and cerebrovascular diseases (stroke). Indeed, these diseases have been seen to disproportionately affect the socioeconomically disadvantaged, albeit to different degrees and with differing magnitude. Mortality rates associated with cardiovascular disease (CVD), including coronary heart disease (CHD) and stroke, were assessed for individuals across areas of differing income and income inequality. The authors found that the mortality rates for each of the three respective diseases were greater by a factor of 1.36, 1.26, and 1.60, in areas of higher inequality compared to lower inequality areas of similar income. Across areas of differing income and constant income inequality, the rate of death due to CVD, CHD and stroke was increased by a factor of 1.27, 1.15, and 1.33 in the lower income areas. These trends across two measures of variation in socioeconomic status reflect the complexity and depth of the relationship between disease and economic standing. The authors are careful to state that while these patterns exist, they are not sufficiently described as related by cause and effect. While correlating, health and status have arisen in the U.S. from interrelated forces that may intricately accumulate or negate one another due to specific historical contexts.

As this lack of cause and effect simplicity indicates, exactly where disease-related health inequality arises is murky, and multiple factors likely contribute. Important to an examination of disease and health in the context of a complicated classification like socioeconomic status is the degree to which these measures are tied up with mechanisms that are dependent upon the individual, and those that are regionally variant. In the aforementioned 2006 study, the authors define individualized factors within three categories, "material (eg, income, possessions, environment), behavioural (eg, diet, smoking, exercise) and psychosocial (eg, perceived inequality, stress)", and provide two categories for external, regionally varying factors, "environmental influences (such as provision of and access to services) and psychosocial influences (such as social support)." The interactive and compounding nature of these forces can shape and be shaped by socioeconomic status, presenting a challenge to researchers to tease apart the intersecting factors of health and status. In the 2006 study, authors examined the specific drivers of the correlation between stroke occurrence and socioeconomic status. Identifying more nuanced and interlocking factors, they cited risk behaviors, early life influences, and access to care as tied to socioeconomic status and thus health inequality.

Inequality in disease is intricately tangled up with stratification of social class and economic status in the United States. Correlations, often disease-dependent, between health and socioeconomic attainment have been demonstrated in numerous studies for numerous diseases. The causes of these correlations are interlocking and often related to factors varying between regions and individuals, and design of future studies concerning inequality in disease require careful thought to the multifaceted driving mechanisms of social inequality.

Environment

The neighbourhood and areas people live in, as well as their occupation, make up the environment in which they exist. People living in poverty stricken neighborhoods are at a greater risk for heart disease, possibly because the supermarkets in their area do not sell healthy foods and there is increased availability of stores selling alcohol and tobacco than in more affluent parts of town. People living in rural areas are also more susceptible to heart disease, as well. An agriculturally based diet rich in fat and cholesterol, combined with an isolated environment in which there is limited access to health care and ways to distribute information probably creates a pattern in which people living in rural environments have higher levels of heart disease. Occupational cancer is one way in which the environment one works in can increase their rate of disease. Employees exposed to smoke, asbestos, diesel fumes, paint, and chemicals in factories can develop cancer from their workplace. All of these jobs tend to be low-paying and typically held by low income individuals. The decreased amount of healthy food in stores located in low-income areas also contributes to the increased rates of diabetes for persons living in those neighborhoods. One of the best examples of this can be seen by observing the city of Jacksonville, Florida.

Food deserts in urban Jacksonville

In Jacksonville, Florida it is hard to find groceries stores around the area because it is surrounded by fats, sugar, and high in cholesterol markets. In Duval County, there are 177,000 food insecure individuals such as children, families,senior citizens, and veterans that do not know when they will have a chance to have another meal again. Nearly 60 percent of the food that is consumed in Duval County is processed. To combat this, agencies helped distribute food and they averaged 12.3 million meals over eight counties in Northern Florida. In Duval alone, 3.5 million meals were handed out to families. The image below shows all of the hunger-relief partner agencies located within Jacksonville's food deserts that get food from Feeding Northeast Florida. In all Feeding Northeast Florida provided 4.2 million pounds of food to agencies in food deserts. These numbers were stats recorded in 2016.

Water pollution

Just like Flint Jacksonville had a water crisis and found 23 different chemicals in their water supply. It was so bad that Jacksonville was labeled top 10 in worst water in the nation. They stood at number 10 because of the 23 different chemicals. The chemicals that were most found in the water in high volumes were trihalomethanes, which is made up of four different cleaning by products such as chloroform. Trihalomethanes are confirmed to be carcinogenic. Throughout the five year testing period, unsafe levels of trihalomethanes were found during the 32 months of testing, and levels that are considered illegal by the EPA were found in 12 of those months. In one of the testing periods the trihalomethanes were found at twice the EPA legal limit. Other chemicals such as lead and arsenic that can cause health problems to people, were also found in the drinking water.

Another way that water pollution is damaged is from nutrient overload. Nutrient overload is caused by manure and fertilizers, storm water runoff, and wastewater treatment plants. This occurs in a lot of Florida rivers and the rivers are contained with blue green algae that feed on all those nutrients. All the waste that is dumped into the rivers gets fed on by other plants and animals that release toxins in the area, which makes everything surrounded by it a deadly toxin as well. The toxins that are dumped into the rivers can cause discoloration in the rivers to make a dark blue and green color. By looking at the river most people can tell how dangerous and harmful it is to be around it. If the water were to somehow get into water companies people can receive serious harm from drinking and bathing with this water.

Education

Education level is a great predictor of socioeconomic status. On average, individuals with a bachelors, associates, and high school degrees will annually earn 64.5, 50, and 41 thousand dollars respectively. This means that the average bachelor's degree earner will receive approximately $1,000,000 more over their working life than an individual with only a high school degree. Furthermore, as authors Montez, Hummer, and Hayward explained, "In 2012, unemployment was 12.4 percent among adults who did not graduate high school, compared to 8.3 percent among adults with a high school diploma and 4.5 percent among college graduates." Because the relationship between socioeconomic status and the prevalence of disease has already been well established, education is indirectly responsible for an increased prevalence of disease among the impoverished.

More directly, educational attainment is a great predictor of how likely an individual is to engage in risky, possibly disease causing, behaviors. In terms of smoking, which directly correlates to an increased risk for diseases like lung cancer, education is an important determining factor in the likelihood of an individual to smoke. As of 2009-10, 35 percent of adults who did not graduate high school were smokers, compared to 30 percent of high school graduates and just 13 percent of college graduates. High school graduates also smoked more packs, on average, each year than smokers who had graduated from college. Furthermore, individuals with a high school degree or less were 30% less likely to abstain from smoking for at least 3 months during their time as a regular smoker Other studies have found that binge drinking is higher among those with college degrees, implying that binge drinking is a habitat developed by many during the college years.

Unhealthy dietary habits can also directly lead to diseases such as heart disease, hypertension, and type-2 diabetes. One of the leading causes of unhealthy eating habits is a lack of access to grocery stores, creating so called "food deserts." Studies have found that immediate access to a grocery store (within 1.5 mile radius) was 1.4 times less likely in areas where only 27%, or less, of the population was college graduates. The negative effects of these food deserts are exacerbated by the fact that impoverished neighborhoods also had an oversupply of liquor store, fast food restaurants, and convenience stores.

One significant risk for sexually active individuals is that of sexually transmitted diseases and infections. While studies have found that the correlation between education and carrying these is relatively low on average (and even less so for certain subsets such as Black women), there is a strong correlation between education and other risky sexual behaviors. Those with only a high school degree or less were significantly more likely to engage in risky practices such as early sexual initiation, sexual activity with those who use "shooting" street drugs such as heroin, and even prostitution. In addition, those with less education were also less likely to practice some safe sex practices such as condom use.

Studies have also found that adults with higher educational achievement were more likely to lead healthier lives. Intake of key nutrients such as Vitamins A and C, potassium, and calcium was positively correlated with education level. This is a critical statistic because those nutrients, such as Vitamin C, are critical in helping the body fight diseases and infections. There was also a correlation between education and exercise habits. A 2010 study found that while 85% of college graduates stated they exercised in the last month, only 68% of high school graduates and 61% of non-high school graduates said the same. Because exercise is so crucial to preventing diseases like hypertension and type 2 diabetes, this stark distinction between exercise habitats can have significant effects. By 2011, 15% of high school (or less) graduates had diabetes, compared to just 7% of college graduates.

Arguably the best way of seeing the true effects of education in the inequality of disease is to examine mortality levels, as Heart Disease, Cancer, and Lower Respiratory Diseases are the top three killers, respectively, of Americans every year. By age 25, if an individual does not have at least a high school degree, they will die an average of 9 years earlier than an otherwise similar college graduate. A different national study found that individuals with only bachelor's degrees were 26% more likely to die in the next 5 years than individuals of the same age with professional degrees such as a master's. Even more stark, Americans without a high school degree were almost twice as likely to die than those with a professional degree in the study's 5 year follow-up period.

Population health

From Wikipedia, the free encyclopedia
 
Income inequality and mortality in 282 metropolitan areas of the United States. Mortality is correlated with both income and inequality.

Population health has been defined as "the health outcomes of a group of individuals, including the distribution of such outcomes within the group". It is an approach to health that aims to improve the health of an entire human population. It has been described as consisting of three components. These are "health outcomes, patterns of health determinants, and policies and interventions".

A priority considered important in achieving the aim of population health is to reduce health inequities or disparities among different population groups due to, among other factors, the social determinants of health (SDOH). The SDOH include all the factors (social, environmental, cultural and physical) that the different populations are born into, grow up and function with throughout their lifetimes which potentially have a measurable impact on the health of human populations. The population health concept represents a change in the focus from the individual-level, characteristic of most mainstream medicine. It also seeks to complement the classic efforts of public health agencies by addressing a broader range of factors shown to impact the health of different populations. The World Health Organization's Commission on Social Determinants of Health, reported in 2008, that the SDOH factors were responsible for the bulk of diseases and injuries and these were the major causes of health inequities in all countries. In the US, SDOH were estimated to account for 70% of avoidable mortality.

From a population health perspective, health has been defined not simply as a state free from disease but as "the capacity of people to adapt to, respond to, or control life's challenges and changes". The World Health Organization (WHO) defined health in its broader sense in 1946 as "a state of complete physical, mental, and social well-being and not merely the absence of disease or infirmity."

Healthy People 2020

Healthy People 2020 is a web site sponsored by the US Department of Health and Human Services, representing the cumulative effort of 34 years of interest by the Surgeon General's office and others. It identifies 42 topics considered social determinants of health and approximately 1200 specific goals considered to improve population health. It provides links to the current research available for selected topics and identifies and supports the need for community involvement considered essential to address these problems realistically.

Economic inequality

Recently, human role has been encouraged by the influence of population growth there has been increasing interest from epidemiologists on the subject of economic inequality and its relation to the health of populations. There is a very robust correlation between socioeconomic status and health. This correlation suggests that it is not only the poor who tend to be sick when everyone else is healthy, heart disease, ulcers, type 2 diabetes, rheumatoid arthritis, certain types of cancer, and premature aging. Despite the reality of the SES Gradient, there is debate as to its cause. A number of researchers (A. Leigh, C. Jencks, A. Clarkwest—see also Russell Sage working papers) see a definite link between economic status and mortality due to the greater economic resources of the better-off, but they find little correlation due to social status differences.

Other researchers such as Richard G. Wilkinson, J. Lynch, and G.A. Kaplan have found that socioeconomic status strongly affects health even when controlling for economic resources and access to health care. Most famous for linking social status with health are the Whitehall studies—a series of studies conducted on civil servants in London. The studies found that, despite the fact that all civil servants in England have the same access to health care, there was a strong correlation between social status and health. The studies found that this relationship stayed strong even when controlling for health-affecting habits such as exercise, smoking and drinking. Furthermore, it has been noted that no amount of medical attention will help decrease the likelihood of someone getting type 1 diabetes or rheumatoid arthritis—yet both are more common among populations with lower socioeconomic status. Lastly, it has been found that amongst the wealthiest quarter of countries on earth (a set stretching from Luxembourg to Slovakia) there is no relation between a country's wealth and general population health—suggesting that past a certain level, absolute levels of wealth have little impact on population health, but relative levels within a country do. The concept of psychosocial stress attempts to explain how psychosocial phenomenon such as status and social stratification can lead to the many diseases associated with the SES gradient. Higher levels of economic inequality tend to intensify social hierarchies and generally degrades the quality of social relations—leading to greater levels of stress and stress related diseases. Richard Wilkinson found this to be true not only for the poorest members of society, but also for the wealthiest. Economic inequality is bad for everyone's health. Inequality does not only affect the health of human populations. David H. Abbott at the Wisconsin National Primate Research Center found that among many primate species, less egalitarian social structures correlated with higher levels of stress hormones among socially subordinate individuals. Research by Robert Sapolsky of Stanford University provides similar findings.

Research

There is well-documented variation in health outcomes and health care utilization & costs by geographic variation in the U.S., down to the level of Hospital Referral Regions (defined as a regional health care market, which may cross state boundaries, of which there are 306 in the U.S.). There is ongoing debate as to the relative contributions of race, gender, poverty, education level and place to these variations. The Office of Epidemiology of the Maternal and Child Health Bureau recommends using an analytic approach (Fixed Effects or hybrid Fixed Effects) to research on health disparities to reduce the confounding effects of neighborhood (geographic) variables on the outcomes.

Critiques

Population health has been subject to ongoing critiques and its assumptions

Subfields

Family planning

Family planning programs (including contraceptives, sexuality education, and promotion of safe sex) play a major role in population health. Family planning is one of the most highly cost-effective interventions in medicine. Family planning saves lives and money by reducing unintended pregnancy and the transmission of sexually transmitted infections.

For example, the United States Agency for International Development lists as benefits of its international family planning program:

  • "Protecting the health of women by reducing high-risk pregnancies"
  • "Protecting the health of children by allowing sufficient time between pregnancies"
  • "Fighting HIV/AIDS through providing information, counseling, and access to male and female condoms"
  • "Reducing abortions"
  • "Supporting women's rights and opportunities for education, employment, and full participation in society"
  • "Protecting the environment by stabilizing population growth"

Mental health

There are three main kinds of population-based approaches to mental health: health care system interventions; public health practice interventions; and social, economic, and environmental policy interventions. Health care system interventions are mediated by the health care system and hospital leaders. Examples of these interventions include enhancing the efficacy of clinical mental health services, providing consultations and training for community partners, and sharing aggregate health data to inform policy, practice, and planning for public mental health. Public health practice interventions are mediated by public health department officials. These interventions include advocating for policy changes, initiating public service announcements to reduce the stigma of mental illness, and conducting outreach to increase the accessibility of community mental health resources. Elected officials and administrative policy makers implement social, economic, and environmental policy interventions. These can include reducing financial and housing insecurity, changing the built environment to increase urban green space and decrease nighttime noise pollution, and reducing structural stigma directed at those with mental illness.

Population health management (PHM)

One method to improve population health is population health management (PHM), which has been defined as "the technical field of endeavor which utilizes a variety of individual, organizational and cultural interventions to help improve the morbidity patterns (i.e., the illness and injury burden) and the health care use behavior of defined populations". PHM is distinguished from disease management by including more chronic conditions and diseases, by use of "a single point of contact and coordination", and by "predictive modeling across multiple clinical conditions". PHM is considered broader than disease management in that it also includes "intensive care management for individuals at the highest level of risk" and "personal health management... for those at lower levels of predicted health risk". Many PHM-related articles are published in Population Health Management, the official journal of DMAA: The Care Continuum Alliance.

The following road map has been suggested for helping healthcare organizations navigate the path toward implementing effective population health management:

  • Establish precise patient registries
  • Determine patient-provider attribution
  • Define precise numerators in the patient registries
  • Monitor and measure clinical and cost metrics
  • Adhere to basic clinical practice guidelines
  • Engage in risk-management outreach
  • Acquire external data
  • Communicate with patients
  • Educate patients and engage with them
  • Establish and adhere to complex clinical practice guidelines
  • Coordinate effectively between care team and patient
  • Track specific outcomes

Healthcare reform and population health

Healthcare reform is driving change to traditional hospital reimbursement models. Prior to the introduction of the Patient Protection and Affordable Care Act (PPACA), hospitals were reimbursed based on the volume of procedures through fee-for-service models. Under the PPACA, reimbursement models are shifting from volume to value. New reimbursement models are built around pay for performance, a value-based reimbursement approach, which places financial incentives around patient outcomes and has drastically changed the way US hospitals must conduct business to remain financially viable. In addition to focusing on improving patient experience of care and reducing costs, hospitals must also focus on improving the health of populations (IHI Triple Aim).

As participation in value-based reimbursement models such as accountable care organizations (ACOs) increases, these initiatives will help drive population health. Within the ACO model, hospitals have to meet specific quality benchmarks, focus on prevention, and carefully manage patients with chronic diseases. Providers get paid more for keeping their patients healthy and out of the hospital. Studies have shown that inpatient admission rates have dropped over the past ten years in communities that were early adopters of the ACO model and implemented population health measures to treat "less sick" patients in the outpatient setting. A study conducted in the Chicago area showed a decline in inpatient utilization rates across all age groups, which was an average of a 5% overall drop in inpatient admissions.

Hospitals are finding it financially advantageous to focus on population health management and keeping people in the community well. The goal of population health management is to improve patient outcomes and increase health capital. Other goals include preventing disease, closing care gaps, and cost savings for providers. In the last few years, more effort has been directed towards developing telehealth services, community-based clinics in areas with high proportion of residents using the emergency department as primary care, and patient care coordinator roles to coordinate healthcare services across the care continuum.

Health can be considered a capital good; health capital is part of human capital as defined by the Grossman model. Health can be considered both an investment good and consumption good. Factors such as obesity and smoking have negative effects on health capital, while education, wage rate, and age may also impact health capital. When people are healthier through preventative care, they have the potential to live a longer and healthier life, work more and participate in the economy, and produce more based on the work done. These factors all have the potential to increase earnings. Some states, like New York, have implemented statewide initiatives to address population health. In New York state there are 11 such programs. One example is the Mohawk Valley Population Health Improvement Program (http://www.mvphip.org/). These programs work to address the needs of the people in their region, as well as assist their local community based organizations and social services to gather data, address health disparities, and explore evidence-based interventions that will ultimately lead to better health for everyone.

Eradication of infectious diseases

From Wikipedia, the free encyclopedia
 
A child suffering from smallpox. In 1980, the World Health Organization announced the global eradication of smallpox. It is the only human disease to be eradicated worldwide.
 
Video recording of a set of presentations given in 2010 about humanity's efforts towards malaria eradication

Eradication is the reduction of an infectious disease's prevalence in the global host population to zero. It is sometimes confused with elimination, which describes either the reduction of an infectious disease's prevalence in a regional population to zero or the reduction of the global prevalence to a negligible amount. Further confusion arises from the use of the term eradication to refer to the total removal of a given pathogen from an individual (also known as clearance of an infection), particularly in the context of HIV and certain other viruses where such cures are sought.

The selection of infectious diseases for eradication is based on rigorous criteria, as both biological and technical features determine whether a pathogenic organism is (at least potentially) eradicable. The targeted organism must not have a non-human reservoir (or, in the case of animal diseases, the infection reservoir must be an easily identifiable species, as in the case of rinderpest), and/or amplify in the environment. This implies that sufficient information on the life cycle and transmission dynamics is available at the time an eradication initiative is programmed. An efficient and practical intervention (such as a vaccine or antibiotic) must be available to interrupt transmission of the infective agent. Studies of measles in the pre-vaccination era led to the concept of the critical community size, the size of the population below which a pathogen ceases to circulate. The use of vaccination programs before the introduction of an eradication campaign can reduce the susceptible population. The disease to be eradicated should be clearly identifiable, and an accurate diagnostic tool should exist. Economic considerations, as well as societal and political support and commitment, are other crucial factors that determine eradication feasibility.

Two infectious diseases have successfully been eradicated: smallpox and rinderpest. There are also four ongoing programs, targeting poliomyelitis, yaws, dracunculiasis, and malaria. Five more infectious diseases have been identified as of April 2008 as potentially eradicable with current technology by the Carter Center International Task Force for Disease Eradication—measles, mumps, rubella, lymphatic filariasis and cysticercosis.

Eradicated diseases

So far, two diseases have been successfully eradicated—one specifically affecting humans (smallpox), and one affecting a wide range of ruminants (rinderpest).

Smallpox

Boy with smallpox (1969). The last natural smallpox case was of Ali Maow Maalin, in Merca, Somalia, on 26 October 1977.

Smallpox was the first disease, and so far the only infectious disease of humans, to be eradicated by deliberate intervention. It became the first disease for which there was an effective vaccine in 1798 when Edward Jenner showed the protective effect of inoculation (vaccination) of humans with material from cowpox lesions.

Smallpox (variola) occurred in two clinical varieties: variola major, with a mortality rate of up to 40 percent, and variola minor, also known as alastrim, with a mortality rate of less than one percent. The last naturally occurring case of Variola major was diagnosed in October 1975 in Bangladesh. The last naturally occurring case of smallpox (Variola minor) was diagnosed on 26 October 1977, on Ali Maow Maalin, in the Merca District, of Somalia. The source of this case was a known outbreak in the nearby district of Kurtuware. All 211 contacts were traced, revaccinated, and kept under surveillance.

After two years' detailed analysis of national records, the global eradication of smallpox was certified by an international commission of smallpox clinicians and medical scientists on 9 December 1979, and endorsed by the General Assembly of the World Health Organization on 8 May 1980. However, there is an ongoing debate regarding the continued storage of the smallpox virus by labs in the US and Russia, as any accidental or deliberate release could create a new epidemic in people born since the late 1980s due to the cessation of vaccinations against the smallpox virus.

Rinderpest

During the twentieth century, there were a series of campaigns to eradicate rinderpest, a viral disease which infected cattle and other ruminants and belonged to the same family as measles, primarily through the use of a live attenuated vaccine. The final, successful campaign was led by the Food and Agriculture Organization of the United Nations. On 14 October 2010, with no diagnoses for nine years, the Food and Agriculture Organization announced that the disease had been completely eradicated, making this the first (and so far the only) disease of livestock to have been eradicated by human undertakings.

Global eradication underway

Poliomyelitis (polio)

International wild poliovirus cases by year
Year Estimated Recorded
1975 49,293
1980 400,000 52,552
1985 38,637
1988 350,000 35,251
1990 23,484
1993 100,000 10,487
1995 7,035
2000 2,971
2005 1,998
2010 1,352
2011 650
2012 222
2013 385
2014 359
2015 74
2016 37
2017 22
2018 33
2019 176

A dramatic reduction of the incidence of poliomyelitis in industrialized countries followed the development of a vaccine in the 1950s. In 1960, Czechoslovakia became the first country certified to have eliminated polio.

In 1988, the World Health Organization (WHO), Rotary International, the United Nations Children's Fund (UNICEF), and the United States Centers for Disease Control and Prevention (CDC) passed the Global Polio Eradication Initiative. Its goal was to eradicate polio by the year 2000. The updated strategic plan for 2004–2008 expects to achieve global eradication by interrupting poliovirus transmission, using the strategies of routine immunization, supplementary immunization campaigns, and surveillance of possible outbreaks. The WHO estimates that global savings from eradication, due to forgone treatment and disability costs, could exceed one billion U.S. dollars per year.

The following world regions have been declared polio-free:

The lowest annual wild polio prevalence seen so far was in 2017, with only 22 reported cases, although there were more total reported cases (including circulated vaccine-derived cases) than in 2016, mainly due to reporting of circulated vaccine-derived cases in Syria, where it likely had already been circulating, but gone unreported, presumably due to the civil war. Only two or three countries remain in which poliovirus transmission may never have been interrupted: Pakistan, Afghanistan, and perhaps Nigeria. (There have been no cases caused by wild strains of poliovirus in Nigeria since August 2016, though cVDPV2 was detected in environmental samples in 2017.) Nigeria was removed from the WHO list of polio-endemic countries in September 2015 but added back in 2016, and India was removed in 2014 after no new cases were reported for one year.

On 20 September 2015, the World Health Organization announced that wild poliovirus type 2 had been eradicated worldwide, as it has not been seen since 1999. On 24 October 2019, the World Health Organization announced that wild poliovirus type 3 had also been eradicated worldwide. This leaves only wild poliovirus type 1 and circulating vaccine-derived polio circulating in a few isolated pockets, with all wild polio cases after August 2016 in Afghanistan and Pakistan.

Dracunculiasis

International Guinea worm cases by year
Year Reported cases Countries
1989 892,055 16
1995 129,852 19
2000 75,223 16
2005 10,674 12
2010 1,797 6
2011 1,060 4
2012 542 4
2013 148 5
2014 126 4
2015 22 4
2016 25 3
2017 30 2
2018 28 3
2019 54 4
2020 24 4

Dracunculiasis, also called Guinea worm disease, is a painful and disabling parasitic disease caused by the nematode Dracunculus medinensis. It is spread through consumption of drinking water infested with copepods hosting Dracunculus larvae. The Carter Center has led the effort to eradicate the disease, along with the CDC, the WHO, UNICEF, and the Bill and Melinda Gates Foundation.

Unlike diseases such as smallpox and polio, there is no vaccine or drug therapy for guinea worm. Eradication efforts have been based on making drinking water supplies safer (e.g. by provision of borehole wells, or through treating the water with larvicide), on containment of infection and on education for safe drinking water practices. These strategies have produced many successes: two decades of eradication efforts have reduced Guinea worm's global incidence to 22 cases in 2015, after which cases rose to 25 cases in 2016, and 30 cases in 2017, but this is still down from an estimated 3.5 million in 1986. Success has been slower than was hoped—the original goal for eradication was 1995. The WHO has certified 180 countries free of the disease, and only three countries—South Sudan, Ethiopia, and Chad—reported cases of guinea worm in 2016, and only two—Ethiopia and Chad—in 2017. As of 2010, the WHO predicted it would be "a few years yet" before eradication is achieved, on the basis that it took 6–12 years for the countries that have so far eliminated guinea worm transmission to do so after reporting a similar number of cases to that reported by Sudan in 2009. The number of cases in 2019 (54) was less than 2% of the number in 2009, so real progress has been made towards this prediction. Nonetheless, the last 1% may be the hardest, and cases have increased from 2015 (22) to 2019 (54). The worm is able to infect dogs, domestic cats and baboons as well as humans, complicating eradication efforts.

Yaws

Yaws is a rarely fatal but highly disfiguring disease caused by the spiral-shaped bacterium (spirochete) Treponema pallidum pertenue, a close relative of the syphilis bacterium Treponema pallidum pallidum, spread through skin to skin contact with infectious lesions. The global prevalence of this disease and the other endemic treponematoses, bejel and pinta, was reduced by the Global Control of Treponematoses (TCP) programme between 1952 and 1964 from about 50 million cases to about 2.5 million (a 95% reduction). However, following the cessation of this program these diseases remained at a low prevalence in parts of Asia, Africa and the Americas with sporadic outbreaks. According to a 2012 official WHO roadmap, the elimination should be achievable by 2020. Yaws is currently targeted by the South-East Asian Regional Office of the WHO for elimination from the remaining endemic countries in this region (India, Indonesia and East Timor) by 2010, and so far, this appears to have met with some success, since no cases have been seen in India since 2004. The discovery that oral antibiotic azithromycin can be used instead of the previous standard, injected penicillin, was tested on Lihir Island from 2013 to 2014; a single oral dose of the macrolide antibiotic reduced disease prevalence from 2.4% to 0.3% at 12 months. The campaign was in an early stage in 2013, still gathering data on disease incidence and planning initial large-scale treatment campaigns in Cameroon, Ghana, Indonesia, Papua New Guinea, the Solomon Islands, and Vanuatu.

Malaria

1962 Pakistani postage stamp promoting malaria eradication program

Malaria has been eliminated from most of Europe, North America, Australia, North Africa and the Caribbean, and parts of South America, Asia and Southern Africa. The WHO defines elimination as having no domestic transmission for the past three years. They also define an "elimination stage" when a country is on the verge of eliminating malaria, as being less than one case per 1000 people at risk per year. As of 2019, 38 countries are certified as having eliminated malaria. As of 2018, 21 countries were seeking to eliminate malaria by 2020. The pre-elimination stage entails fewer than 5 cases per 1000 people at risk per year.

In 1955 the WHO launched the Global Malaria Eradication Program (GMEP). Support waned, and the program was suspended in 1969. Since 2000, support for eradication has increased, although some people in the global health community remain sceptical. According to the WHO's World Malaria Report 2015, the global mortality rate for malaria fell by 60% between 2000 and 2015. The WHO aims to achieve a further 90% reduction between 2015 and 2030. Bill Gates believes that global eradication is possible by 2040.

A major challenge to malaria elimination is the persistence of malaria in border regions, making international cooperation crucial.

Regional elimination established or underway

Some diseases have already been eliminated from large regions of the world, and/or are currently being targeted for regional elimination. This is sometimes described as "eradication", although technically the term only applies when this is achieved on a global scale. Even after regional elimination is successful, interventions often need to continue to prevent a disease becoming re-established. Three of the diseases here listed (lymphatic filariasis, measles, and rubella) are among the diseases believed to be potentially eradicable by the International Task Force for Disease Eradication, and if successful, regional elimination programs may yet prove a stepping stone to later global eradication programs. This section does not cover elimination where it is used to mean control programs sufficiently tight to reduce the burden of an infectious disease or other health problem to a level where they may be deemed to have little impact on public health, such as the leprosy, neonatal tetanus, or obstetric fistula campaigns.

Hookworm

In North American countries, such as the United States, elimination of hookworm had been attained due to scientific advances. Despite the United States declaring that it had eliminated hookworm decades ago, a 2017 study showed it was present in Lowndes County, Alabama.

The Rockefeller Foundation's hookworm campaign in the 1920s was supposed to focus on the eradication of hookworm infections for those living in Mexico and other rural areas. However, the campaign was politically influenced, causing it to be less successful, and regions such as Mexico still deal with these infections from parasitic worms. This use of health campaigns by political leaders for political and economic advantages has been termed the science-politics paradox.

Lymphatic filariasis

Lymphatic filariasis is an infection of the lymph system by mosquito-borne microfilarial worms which can cause elephantiasis. Studies have demonstrated that transmission of the infection can be broken when a single dose of combined oral medicines is consistently maintained annually for approximately seven years. The strategy for eliminating transmission of lymphatic filariasis is mass distribution of medicines that kill the microfilariae and stop transmission of the parasite by mosquitoes in endemic communities. In sub-Saharan Africa, albendazole is being used with ivermectin to treat the disease, whereas elsewhere in the world albendazole is used with diethylcarbamazine. Using a combination of treatments better reduces the number of microfilariae in blood. Avoiding mosquito bites, such as by using insecticide-treated mosquito bed nets, also reduces the transmission of lymphatic filariasis. In the Americas, 95% of the burden of lymphatic filariasis is on the island of Hispaniola (comprising Haiti and the Dominican Republic). An elimination effort to address this is currently under way alongside the malaria effort described above; both countries intend to eliminate the disease by 2020.

As of October 2008, the efforts of the Global Programme to Eliminate LF are estimated to have already prevented 6.6 million new filariasis cases from developing in children, and to have stopped the progression of the disease in another 9.5 million people who have already contracted it. Overall, of 83 endemic countries, mass treatment has been rolled out in 48, and elimination of transmission reportedly achieved in 21.

Measles

Five out of six WHO regions have goals to eliminate measles, and at the 63rd World Health Assembly in May 2010, delegates agreed to move towards eventual eradication, although no specific global target date has yet been agreed. The Americas set a goal in 1994 to eliminate measles and rubella transmission by 2000, and successfully achieved regional measles elimination in 2002, although there have been occasional small outbreaks from imported cases since then. Europe had set a goal to eliminate measles transmission by 2010, but were hindered by the MMR vaccine controversy and by low uptake in certain groups, and despite achieving low levels by 2008, European countries have since experienced a small resurgence in cases. They have set a new target of 2015. The Eastern Mediterranean also had goals to eliminate measles by 2010 (later revised to 2015), the Western Pacific aims to eliminate the disease by 2012, and in 2009 the regional committee for Africa agreed a goal of measles elimination by 2020. As of May 2010, only the South-East Asian region has yet to set a target date for elimination of measles transmission.

In 2005, a global target was agreed for a 90% reduction in measles deaths by 2010 from the 757,000 deaths in 2000; estimates for 2008 show a 78% decline so far to 164,000 deaths. However, some have been pushing to attempt global eradication. This was updated at the 2010 World Health Assembly to a targeted 95% reduction in mortality by 2015, alongside specific vaccination and structural targets, and in a meeting in November 2010, the Strategic Advisory Group of Experts on Immunization "concluded that measles can and should be eradicated". A study of the costs of eradicating measles compared to the costs of maintaining indefinite control was commissioned in 2009 by the WHO and the Bill and Melinda Gates Foundation. In 2013, measles deaths globally were down to 145,700.

As of mid-2013, measles elimination in many areas is stalling. "This year, measles and rubella outbreaks are occurring in many areas of the world where people have no immunity to these viruses. The reasons people are unvaccinated range from lack of access to vaccines in areas of insecurity, to poor performing health systems, to vaccine refusals. We need to address each of these challenges if we’re going to meet global measles and rubella elimination goals," said Dr. Myrna Charles of the American Red Cross, as reported in a post in the Measles and Rubella Initiative's blog. A look at the WHO's epidemiological graph of measles over time from 2008-2013 show that, with little more of two years to go to 2015, measles cases in 2013 are moving in the wrong direction, with more cases this year than at the same point in 2012 or 2011.

During 2014 there were 23 outbreaks of measles in the United States and over 600 individual cases, which is the highest seen in decades. In 2015 the US has had one major outbreak of measles originating from an amusement park in California of a variant of the virus circulating in the Philippines in 2014. From this there have been 113 individual measles cases and one death (out of the total of 189 cases in the US in 2015).

The WHO region of the Americas declared on 27 September 2016 it had eliminated measles. The last confirmed endemic case of measles in the Americas was in Brazil in July 2015. May 2017 saw a return of measles to the US after an outbreak in Minnesota among unvaccinated children. Another outbreak occurred in the state of New York between 2018 and 2019, causing over 200 confirmed measles cases in mostly ultra-Orthodox Jewish communities. Subsequent outbreaks occurred in New Jersey and Washington state with over 30 cases reported in the Pacific Northwest.

Rubella

Four out of six WHO regions have goals to eliminate rubella, with the WHO recommending using existing measles programmes for vaccination with combined vaccines such as the MMR vaccine. The number of reported cases dropped from 670 thousand in the year 2000 to below 15 thousand in 2018, and the global coverage of rubella vaccination was estimated at 69% in 2018 by the WHO. The WHO region of the Americas declared on 29 April 2015 it had eliminated rubella and congenital rubella syndrome. The last confirmed endemic case of rubella in the Americas was in Argentina in February 2009. Australia achieved eradication in 2018. The WHO European region missed its elimination target of 2010 due to undervaccination in Central and Western Europe; it has set a new goal of 2015. The disease remains problematic in other regions; the WHO regions of Africa and South-East Asia have the highest rates of congenital rubella syndrome and a 2013 outbreak of rubella in Japan resulted in 15,000 cases.

Onchocerciasis

Onchocerciasis (river blindness) is the world's second leading cause of infectious blindness. It is caused by the nematode Onchocerca volvulus, which is transmitted to people via the bite of a black fly. Elimination of this disease is under way in the region of the Americas, where this disease was endemic to Brazil, Colombia, Ecuador, Guatemala, Mexico and Venezuela. The principal tool being used is mass ivermectin treatment. If successful, the only remaining endemic locations would be in Africa and Yemen. In Africa, it is estimated that greater than 102 million people in 19 countries are at high risk of onchocerciasis infection, and in 2008, 56.7 million people in 15 of these countries received community-directed treatment with ivermectin. Since adopting such treatment measures in 1997, the African Programme for Onchocerciasis Control reports a reduction in the prevalence of onchocerciasis in the countries under its mandate from a pre-intervention level of 46.5% in 1995 to 28.5% in 2008. Some African countries, such as Uganda, are also attempting elimination and successful elimination was reported in 2009 from two endemic foci in Mali and Senegal.

On 29 July 2013, the Pan American Health Organization (PAHO) announced that after 16 years of efforts, Colombia had become the first country in the world to eliminate the parasitic disease onchocerciasis. It has also been eliminated in Ecuador (2014), Mexico (2015), and Guatemala (2016).

Bovine spongiform encephalopathy (BSE) and new variant Creutzfeldt–Jakob disease (vCJD)

Following an epidemic of variant Creutzfeldt–Jakob disease (vCJD) in the UK in the 1990s, there have been campaigns to eliminate bovine spongiform encephalopathy (BSE) in cattle across the European Union and beyond which have achieved large reductions in the number of cattle with this disease. Cases of vCJD have also fallen since then, from an annual peak of 29 cases in 2000 to five in 2008 and none in 2012. Two cases were reported in both 2013 and 2014: two in France; one in the United Kingdom and one in the United States.

Following the ongoing eradication effort, only seven cases of BSE were reported worldwide in 2013: three in the United Kingdom, two in France, one in Ireland and one in Poland. This is the lowest number of cases since at least 1988. In 2015 there were at least six reported cases (three of the atypical H-type.

Syphilis

In 2015, Cuba became the first country in the world to eliminate mother-to-child syphilis. In 2017 the WHO declared that Antigua and Barbuda, Saint Kitts and Nevis and four British Overseas TerritoriesAnguilla, Bermuda, Cayman Islands, and Montserrat—have been certified that they have ended transmission of mother-to-child syphilis and HIV. Nevertheless eradication of syphilis by all transmission methods remains unresolved and many questions about the eradication effort remain to be answered.

African trypanosomiasis

Early planning by the WHO for the eradication of African trypanosomiasis, also known as sleeping sickness, is underway as the rate of reported cases continues to decline and passive treatment is continued. The WHO aims to completely eliminate transmission of the Trypanosoma brucei gambiense parasite by 2030, though it acknowledges that this goal "leaves no room for complacency."

Rabies

Rabies-free countries and territories as of 2018

Because the rabies virus is almost always caught from animals, rabies eradication has focused on reducing the population of wild and stray animals, controls and compulsory quarantine on animals entering the country, and vaccination of pets and wild animals. Many island nations, including Iceland, Ireland, Japan, Malta, and the United Kingdom, managed to eliminate rabies during the twentieth century, and more recently much of continental Europe has been declared rabies-free.

Eradicable diseases in animals

As far as animal diseases are concerned, now that rinderpest has been stamped out, many experts believe peste des petits ruminants (PPR) is the next disease amenable to global eradication. Also known as goat plague or ovine rinderpest, PPR is a highly contagious viral disease of goats and sheep characterized by fever, painful sores in the mouth, tongue and feet, diarrhea, pneumonia and death, especially in young animals. It is caused by a virus of the genus Morbillivirus that is related to rinderpest, measles and canine distemper.

Eradication difficulties

Public upheaval by means of war, famine, political means, and infrastructure destruction can disrupt or eliminate eradication efforts altogether.

Late Devonian extinction

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