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Thursday, June 25, 2020

Trotskyism

From Wikipedia, the free encyclopedia
 
Trotskyism is the theory of Marxism as advocated by the Russian revolutionary Leon Trotsky. Trotsky identified as an orthodox Marxist and BolshevikLeninist. He supported founding a vanguard party of the proletariat, proletarian internationalism and a dictatorship of the proletariat based on working class self-emancipation and mass democracy. Trotskyists are critical of Stalinism as they oppose Joseph Stalin's theory of socialism in one country in favor of Trotsky's theory of permanent revolution. Trotskyists also criticize the bureaucracy that developed in the Soviet Union under Stalin.

Vladimir Lenin and Trotsky were close both ideologically and personally during the Russian Revolution and its aftermath, and some call Trotsky its "co-leader". Trotsky was the paramount leader of the Red Army in the direct aftermath of the Revolutionary period. Trotsky initially opposed some aspects of Leninism, but he concluded that unity between the Mensheviks and Bolsheviks was impossible and joined the Bolsheviks. Trotsky played a leading role with Lenin in the revolution. Assessing Trotsky, Lenin wrote: "Trotsky long ago said that unification is impossible. Trotsky understood this and from that time on there has been no better Bolshevik."

Under Stalin's orders, Trotsky was removed from power (October 1927), expelled from the All-Union Communist Party (Bolsheviks) (November 1927), exiled first to Alma-Ata (January 1928), and then from the Soviet Union (February 1929). As the head of the Fourth International, Trotsky continued from exile to oppose the Stalinist bureaucracy in the Soviet Union. On 20 August 1940, Trotsky was attacked by Ramón Mercader, a Spanish-born NKVD agent, and died the next day in a hospital. His murder is considered a political assassination. Almost all of the Trotskyists within the All-Union Communist Party (Bolsheviks) were executed in the Great Purges of 1937–1938, effectively removing all of Trotsky's internal influence in the Soviet Union.

Trotsky's Fourth International was established in France in 1938, when Trotskyists argued that the Comintern or Third International had become irretrievably "lost to Stalinism" and thus incapable of leading the international working class to political power. In contemporary English language usage, an advocate of Trotsky's ideas is often called a "Trotskyist". A Trotskyist can be called a "Trotskyite" or "Trot", especially by a critic of Trotskyism.

Definition

The leaders of the Trotskyist Left Opposition in Moscow, 1927 (sitting: Leonid Serebryakov, Karl Radek, Leon Trotsky, Mikhail Boguslavsky and Yevgeni Preobrazhensky; standing: Christian Rakovsky, Yakov Drobnis, Alexander Beloborodov and Lev Sosnovsky)
 
According to Trotsky, his program could be distinguished from other Marxist theories by five key elements:
On the political spectrum of Marxism, Trotskyists are usually considered to be towards the left. In the 1920s they called themselves the Left Opposition, although today's left communism is distinct and usually non-Bolshevik. The terminological disagreement can be confusing because different versions of a left-right political spectrum are used. Anti-revisionists consider themselves the ultimate leftists on a spectrum from communism on the left to imperialist capitalism on the right, but given that Stalinism is often labeled rightist within the communist spectrum and left communism leftist, anti-revisionists' idea of left is very different from that of left communism. Despite being Bolshevik-Leninist comrades during the Russian Revolution and Russian Civil War, Trotsky and Stalin became enemies in the 1920s and thereafter opposed the legitimacy of each other's forms of Leninism. Trotsky was extremely critical of the Stalinist USSR for suppressing democracy and lack of adequate economic planning.

Theory

In 1905, Trotsky formulated his theory of permanent revolution that later became a defining characteristic of Trotskyism. Until 1905, some revolutionaries claimed that Marx's theory of history posited that only a revolution in a European capitalist society would lead to a socialist one. According to this position, it was impossible for a socialist revolution to occur in a backward, feudal country such as early 20th century Russia when it had such a small and almost powerless capitalist class.

The theory of permanent revolution addressed the question of how such feudal regimes were to be overthrown and how socialism could be established given the lack of economic prerequisites. Trotsky argued that in Russia only the working class could overthrow feudalism and win the support of the peasantry. Furthermore, he argued that the Russian working class would not stop there. They would win their own revolution against the weak capitalist class, establish a workers' state in Russia and appeal to the working class in the advanced capitalist countries around the world. As a result, the global working class would come to Russia's aid and socialism could develop worldwide.

Capitalist or bourgeois-democratic revolution

Revolutions in Britain in the 17th century and in France in 1789 abolished feudalism and established the basic requisites for the development of capitalism. Trotsky argued that these revolutions would not be repeated in Russia.

In Results and Prospects, written in 1906, Trotsky outlines his theory in detail, arguing: "History does not repeat itself. However much one may compare the Russian Revolution with the Great French Revolution, the former can never be transformed into a repetition of the latter." In the French Revolution of 1789, France experienced what Marxists called a "bourgeois-democratic revolution"—a regime was established wherein the bourgeoisie overthrew the existing French feudalistic system. The bourgeoisie then moved towards establishing a regime of democratic parliamentary institutions. However, while democratic rights were extended to the bourgeoisie, they were not generally extended to a universal franchise. The freedom for workers to organize unions or to strike was not achieved without considerable struggle.

Passivity of the bourgeoisie

Trotsky argues that countries like Russia had no "enlightened, active" revolutionary bourgeoisie which could play the same role and the working class constituted a very small minority. By the time of the European revolutions of 1848, "the bourgeoisie was already unable to play a comparable role. It did not want and was not able to undertake the revolutionary liquidation of the social system that stood in its path to power."

The theory of permanent revolution considers that in many countries that are thought under Trotskyism to have not yet completed a bourgeois-democratic revolution, the capitalist class opposes the creation of any revolutionary situation. They fear stirring the working class into fighting for its own revolutionary aspirations against their exploitation by capitalism. In Russia, the working class, although a small minority in a predominantly peasant-based society, were organised in vast factories owned by the capitalist class and into large working-class districts. During the Russian Revolution of 1905, the capitalist class found it necessary to ally with reactionary elements such as the essentially feudal landlords and ultimately the existing Czarist Russian state forces. This was to protect their ownership of their property—factories, banks, etc.—from expropriation by the revolutionary working class.

Therefore, according to the theory of permanent revolution the capitalist classes of economically backward countries are weak and incapable of carrying through revolutionary change. As a result, they are linked to and rely on the feudal landowners in many ways. Thus Trotsky argues that because a majority of the branches of industry in Russia were originated under the direct influence of government measures—sometimes with the help of government subsidies—the capitalist class was again tied to the ruling elite. The capitalist class were subservient to European capital.

Incapability of the peasantry

The theory of permanent revolution further considers that the peasantry as a whole cannot take on the task of carrying through the revolution, because it is dispersed in smallholdings throughout the country and forms a heterogeneous grouping, including the rich peasants who employ rural workers and aspire to landlordism as well as the poor peasants who aspire to own more land. Trotsky argues: "All historical experience [...] shows that the peasantry are absolutely incapable of taking up an independent political role".

The key role of the proletariat

Trotskyists differ on the extent to which this is true today, but even the most orthodox tend to recognise in the late twentieth century a new development in the revolts of the rural poor, the self-organising struggles of the landless; and many other struggles which in some ways reflect the militant united organised struggles of the working class; and which to various degrees do not bear the marks of class divisions typical of the heroic peasant struggles of previous epochs. However, orthodox Trotskyists today still argue that the town- and city-based working-class struggle is central to the task of a successful socialist revolution, linked to these struggles of the rural poor. They argue that the working class learns of necessity to conduct a collective struggle, for instance in trade unions, arising from its social conditions in the factories and workplaces; and that the collective consciousness it achieves as a result is an essential ingredient of the socialist reconstruction of society.

Trotsky himself argued that only the proletariat or working class were capable of achieving the tasks of that bourgeois revolution. In 1905, the working class in Russia, a generation brought together in vast factories from the relative isolation of peasant life, saw the result of its labour as a vast collective effort and the only means of struggling against its oppression in terms of a collective effort and forming workers councils (soviets) in the course of the revolution of that year. In 1906, Trotsky argued:
The factory system brings the proletariat to the foreground [...] The proletariat immediately found itself concentrated in tremendous masses, while between these masses and the autocracy there stood a capitalist bourgeoisie, very small in numbers, isolated from the "people", half-foreign, without historical traditions, and inspired only by the greed for gain.
— Leon Trotsky, Results and Prospects
For instance, the Putilov Factory numbered 12,000 workers in 1900 and according to Trotsky 36,000 in July 1917.

Although only a small minority in Russian society, the proletariat would lead a revolution to emancipate the peasantry and thus "secure the support of the peasantry" as part of that revolution, on whose support it will rely. However, in order to improve their own conditions the working class will find it necessary to create a revolution of their own, which would accomplish both the bourgeois revolution and then establish a workers' state.

International revolution

According to classical Marxism, revolution in peasant-based countries such as Russia prepares the ground ultimately only for a development of capitalism since the liberated peasants become small owners, producers and traders which leads to the growth of commodity markets, from which a new capitalist class emerges. Only fully developed capitalist conditions prepare the basis for socialism.

Trotsky agreed that a new socialist state and economy in a country like Russia would not be able to hold out against the pressures of a hostile capitalist world as well as the internal pressures of its backward economy. The revolution, Trotsky argued, must quickly spread to capitalist countries, bringing about a socialist revolution which must spread worldwide. In this way the revolution is "permanent", moving out of necessity first, from the bourgeois revolution to the workers’ revolution and from there uninterruptedly to European and worldwide revolutions.

An internationalist outlook of permanent revolution is found in the works of Karl Marx. The term "permanent revolution" is taken from a remark of Marx from his March 1850 Address: "it is our task", Marx said:
[...] to make the revolution permanent until all the more or less propertied classes have been driven from their ruling positions, until the proletariat has conquered state power and until the association of the proletarians has progressed sufficiently far—not only in one country but in all the leading countries of the world—that competition between the proletarians of these countries ceases and at least the decisive forces of production are concentrated in the hands of the workers.
— Karl Marx, Address of the Central Committee to the Communist League

History

Origins

Trotsky in exile in Siberia, 1900
 
According to Trotsky, the term "Trotskyism" was coined by Pavel Milyukov (sometimes transliterated as Paul Miliukoff), the ideological leader of the Constitutional Democratic Party (Kadets) in Russia. Milyukov waged a bitter war against Trotskyism "as early as 1905".

Trotsky was elected chairman of the St. Petersburg Soviet during the Russian Revolution of 1905. He pursued a policy of proletarian revolution at a time when other socialist trends advocated a transition to a "bourgeois" (capitalist) regime to replace the essentially feudal Romanov state. It was during this year that Trotsky developed the theory of permanent revolution, as it later became known (see below). In 1905, Trotsky quotes from a postscript to a book by Milyukov, The Elections to the Second State Duma, published no later than May 1907:
Those who reproach the Kadets with failure to protest at that time, by organising meetings, against the "revolutionary illusions" of Trotskyism and the relapse into Blanquism, simply do not understand [...] the mood of the democratic public at meetings during that period.
— Pavel Milyukov, The Elections to the Second State Duma
Milyukov suggests that the mood of the "democratic public" was in support of Trotsky's policy of the overthrow of the Romanov regime alongside a workers' revolution to overthrow the capitalist owners of industry, support for strike action and the establishment of democratically elected workers' councils or "soviets".

Trotskyism and the 1917 Russian Revolution

During his leadership of the Russian revolution of 1905, Trotsky argued that once it became clear that the Tsar's army would not come out in support of the workers, it was necessary to retreat before the armed might of the state in as good an order as possible. In 1917, Trotsky was again elected chairman of the Petrograd soviet, but this time soon came to lead the Military Revolutionary Committee which had the allegiance of the Petrograd garrison and carried through the October 1917 insurrection. Stalin wrote:
All practical work in connection with the organisation of the uprising was done under the immediate direction of Comrade Trotsky, the President of the Petrograd Soviet. It can be stated with certainty that the Party is indebted primarily and principally to Comrade Trotsky for the rapid going over of the garrison to the side of the Soviet and the efficient manner in which the work of the Military Revolutionary Committee was organized.
— Joseph Stalin, Pravda, November 6, 1918
As a result of his role in the Russian Revolution of 1917, the theory of permanent revolution was embraced by the young Soviet state until 1924.

The Russian revolution of 1917 was marked by two revolutions: the relatively spontaneous February 1917 revolution, and the 25 October 1917 seizure of power by the Bolsheviks, who had gained the leadership of the Petrograd soviet.

Before the February 1917 Russian revolution, Lenin had formulated a slogan calling for the "democratic dictatorship of the proletariat and the peasantry", but after the February revolution through his April Theses, Lenin instead called for "all power to the Soviets". Lenin nevertheless continued to emphasise (as did Trotsky also) the classical Marxist position that the peasantry formed a basis for the development of capitalism, not socialism.
Also before February 1917, Trotsky had not accepted the importance of a Bolshevik style organisation. Once the February 1917 Russian revolution had broken out, Trotsky admitted the importance of a Bolshevik organisation and joined the Bolsheviks in July 1917. Despite the fact that many like Stalin saw Trotsky's role in the October 1917 Russian revolution as central, Trotsky wrote that without Lenin and the Bolshevik Party, the October revolution of 1917 would not have taken place.

As a result, since 1917 Trotskyism as a political theory is fully committed to a Leninist style of democratic centralist party organisation, which Trotskyists argue must not be confused with the party organisation as it later developed under Stalin. Trotsky had previously suggested that Lenin's method of organisation would lead to a dictatorship, but it is important to emphasise that after 1917 orthodox Trotskyists argue that the loss of democracy in the Soviet Union was caused by the failure of the revolution to spread internationally and the consequent wars, isolation, and imperialist intervention, not the Bolshevik style of organisation.

Lenin's outlook had always been that the Russian revolution would need to stimulate a Socialist revolution in Western Europe in order that this European socialist society would then come to the aid of the Russian revolution and enable Russia to advance towards socialism. Lenin stated:
We have stressed in a good many written works, in all our public utterances, and in all our statements in the press that [...] the socialist revolution can triumph only on two conditions. First, if it is given timely support by a socialist revolution in one or several advanced countries.
— Vladimir Lenin, Speech at Tenth Congress of the RCP(B)
This outlook matched precisely Trotsky's theory of permanent revolution. Trotsky's permanent revolution had foreseen that the working class would not stop at the bourgeois democratic stage of the revolution, but proceed towards a workers' state as happened in 1917. The Polish Trotskyist Isaac Deutscher maintains that in 1917 Lenin changed his attitude to Trotsky's theory of Permanent Revolution and after the October revolution it was adopted by the Bolsheviks.

Lenin was met with initial disbelief in April 1917. Trotsky argues that:
[...] up to the outbreak of the February revolution and for a time after Trotskyism did not mean the idea that it was impossible to build a socialist society within the national boundaries of Russia (which "possibility" was never expressed by anybody up to 1924 and hardly came into anybody’s head). Trotskyism meant the idea that the Russian proletariat might win the power in advance of the Western proletariat, and that in that case it could not confine itself within the limits of a democratic dictatorship but would be compelled to undertake the initial socialist measures. It is not surprising, then, that the April theses of Lenin were condemned as Trotskyist.
— Leon Trotsky, History of the Russian Revolution

"Legend of Trotskyism"

"Bolshevik freedom" with nude of Trotsky in a Polish propaganda poster, Polish–Soviet War (1920)

In The Stalin School of Falsification, Trotsky argues that what he calls the "legend of Trotskyism" was formulated by Grigory Zinoviev and Lev Kamenev in collaboration with Stalin in 1924 in response to the criticisms Trotsky raised of Politburo policy. Orlando Figes argues: "The urge to silence Trotsky, and all criticism of the Politburo, was in itself a crucial factor in Stalin's rise to power".

During 1922–1924, Lenin suffered a series of strokes and became increasingly incapacitated. Before his death in 1924, while describing Trotsky as "distinguished not only by his exceptional abilities—personally he is, to be sure, the most able man in the present Central Committee" and also maintaining that "his non-Bolshevik past should not be held against him", Lenin criticized him for "showing excessive preoccupation with the purely administrative side of the work" and also requested that Stalin be removed from his position of General Secretary, but his notes remained suppressed until 1956. Zinoviev and Kamenev broke with Stalin in 1925 and joined Trotsky in 1926 in what was known as the United Opposition.

In 1926, Stalin allied with Nikolai Bukharin, who then led the campaign against "Trotskyism". In The Stalin School of Falsification, Trotsky quotes Bukharin's 1918 pamphlet, From the Collapse of Czarism to the Fall of the Bourgeoisie, which was re-printed in 1923 by the party publishing house, Proletari. In this pamphlet, Bukharin explains and embraces Trotsky's theory of permanent revolution, writing: "The Russian proletariat is confronted more sharply than ever before with the problem of the international revolution ... The grand total of relationships which have arisen in Europe leads to this inevitable conclusion. Thus, the permanent revolution in Russia is passing into the European proletarian revolution". Yet it is common knowledge, Trotsky argues, that three years later in 1926 "Bukharin was the chief and indeed the sole theoretician of the entire campaign against 'Trotskyism', summed up in the struggle against the theory of the permanent revolution."

Trotsky wrote that the Left Opposition grew in influence throughout the 1920s, attempting to reform the Communist Party, but in 1927 Stalin declared "civil war" against them:
During the first ten years of its struggle, the Left Opposition did not abandon the program of ideological conquest of the party for that of conquest of power against the party. Its slogan was: reform, not revolution. The bureaucracy, however, even in those times, was ready for any revolution in order to defend itself against a democratic reform.
In 1927, when the struggle reached an especially bitter stage, Stalin declared at a session of the Central Committee, addressing himself to the Opposition: "Those cadres can be removed only by civil war!" What was a threat in Stalin’s words became, thanks to a series of defeats of the European proletariat, a historic fact. The road of reform was turned into a road of revolution.
— Leon Trotsky, The Revolution Betrayed: What Is the Soviet Union and Where Is It Going?, p. 279, Pathfinder
Defeat of the European working class led to further isolation in Russia and further suppression of the Opposition. Trotsky argued that the "so-called struggle against 'Trotskyism' grew out of the bureaucratic reaction against the October Revolution [of 1917]". He responded to the one-sided civil war with his Letter to the Bureau of Party History (1927), contrasting what he claimed to be the falsification of history with the official history of just a few years before. He further accused Stalin of derailing the Chinese revolution and causing the massacre of the Chinese workers:
In the year 1918, Stalin, at the very outset of his campaign against me, found it necessary, as we have already learned, to write the following words:
"All the work of practical organization of the insurrection was carried out under the direct leadership of the Chairman of the Petrograd Soviet, comrade Trotsky..." (Stalin, Pravda, 6 November 1918)
With full responsibility for my words, I am now compelled to say that the cruel massacre of the Chinese proletariat and the Chinese Revolution at its three most important turning points, the strengthening of the position of the trade union agents of British imperialism after the General Strike of 1926, and, finally, the general weakening of the position of the Communist International and the Soviet Union, the party owes principally and above all to Stalin.
— Leon Trotsky, The Stalin School of Falsification, p. 87, Pathfinder (1971).
Trotsky was sent into internal exile and his supporters were jailed. For instance, Victor Serge first "spent six weeks in a cell" after a visit at midnight, then 85 days in an inner GPU cell, most of it in solitary confinement. He details the jailings of the Left Opposition. However, the Left Opposition continued to work in secret within the Soviet Union. Trotsky was eventually exiled to Turkey and moved from there to France, Norway and finally to Mexico.

After 1928, the various Communist Parties throughout the world expelled Trotskyists from their ranks. Most Trotskyists defend the economic achievements of the planned economy in the Soviet Union during the 1920s and 1930s, despite the "misleadership" of the Soviet bureaucracy and what they claim to be the loss of democracy. Trotskyists claim that in 1928 inner party democracy and indeed soviet democracy, which was at the foundation of Bolshevism, had been destroyed within the various Communist Parties. Anyone who disagreed with the party line was labeled a Trotskyist and even a fascist.

In 1937, Stalin again unleashed what Trotskyists say was a political terror against their Left Opposition and many of the remaining Old Bolsheviks (those who had played key roles in the October Revolution in 1917) in the face of increased opposition, particularly in the army.

Founding of the Fourth International

Trotsky with Vladimir Lenin and soldiers in Petrograd
 
Trotsky founded the International Left Opposition in 1930. It was meant to be an opposition group within the Comintern, but anyone who joined or was suspected of joining the ILO was immediately expelled from the Comintern. The ILO, therefore, concluded that opposing Stalinism from within the communist organizations controlled by Stalin's supporters had become impossible, so new organizations had to be formed. In 1933, the ILO was renamed the International Communist League (ICL), which formed the basis of the Fourth International, founded in Paris in 1938.

Trotsky said that only the Fourth International, basing itself on Lenin's theory of the vanguard party, could lead the world revolution and that it would need to be built in opposition to both the capitalists and the Stalinists. 

Trotsky argued that the defeat of the German working class and the coming to power of Hitler in 1933 was due in part to the mistakes of the Third Period policy of the Communist International and that the subsequent failure of the Communist Parties to draw the correct lessons from those defeats showed that they were no longer capable of reform and a new international organisation of the working class must be organised. The transitional demand tactic had to be a key element.

At the time of the founding of the Fourth International in 1938, Trotskyism was a mass political current in Vietnam, Sri Lanka and slightly later Bolivia. There was also a substantial Trotskyist movement in China which included the founding father of the Chinese communist movement, Chen Duxiu, amongst its number. Wherever Stalinists gained power, they made it a priority to hunt down Trotskyists and treated them as the worst of enemies.

The Fourth International suffered repression and disruption through the Second World War. Isolated from each other and faced with political developments quite unlike those anticipated by Trotsky, some Trotskyist organizations decided that the Soviet Union no longer could be called a degenerated workers' state and withdrew from the Fourth International. After 1945, Trotskyism was smashed as a mass movement in Vietnam and marginalised in a number of other countries.

Antonov-Ovseyenko was the first former Trotskyist to be posthumously rehabilitated

The International Secretariat of the Fourth International (ISFI) organised an international conference in 1946 and then World Congresses in 1948 and 1951 to assess the expropriation of the capitalists in Eastern Europe and Yugoslavia, the threat of a Third World War and the tasks for revolutionaries. The Eastern European Communist-led governments which came into being after World War II without a social revolution were described by a resolution of the 1948 congress as presiding over capitalist economies. By 1951, the Congress had concluded that they had become "deformed workers' states". As the Cold War intensified, the ISFI's 1951 World Congress adopted theses by Michel Pablo that anticipated an international civil war. Pablo's followers considered that the Communist Parties, insofar as they were placed under pressure by the real workers' movement, could escape Stalin's manipulations and follow a revolutionary orientation.

The 1951 Congress argued that Trotskyists should start to conduct systematic work inside those Communist Parties which were followed by the majority of the working class. However, the ISFI's view that the Soviet leadership was counter-revolutionary remained unchanged. The 1951 Congress argued that the Soviet Union took over these countries because of the military and political results of World War II and instituted nationalized property relations only after its attempts at placating capitalism failed to protect those countries from the threat of incursion by the West. 


Pablo began expelling large numbers of people who did not agree with his thesis and who did not want to dissolve their organizations within the Communist Parties. For instance, he expelled the majority of the French section and replaced its leadership. As a result, the opposition to Pablo eventually rose to the surface, with the Open Letter to Trotskyists of the World, by Socialist Workers Party leader James P. Cannon.

The Fourth International split in 1953 into two public factions. The International Committee of the Fourth International (ICFI) was established by several sections of the International as an alternative centre to the International Secretariat, in which they felt a revisionist faction led by Michel Pablo had taken power and recommitted themselves to the Lenin-Trotsky Theory of the Party and Trotsky's theory of Permanent Revolution. From 1960, led by the U.S Socialist Workers Party, a number of ICFI sections began the reunification process with the IS, but factions split off and continued their commitment to the ICFI. Today, national parties committed to the ICFI call themselves the Socialist Equality Party.

Trotskyist movements

Latin America


United Socialist Workers' Party in Brazil, June 2014

The Bolivian Trotskyist party (Partido Obrero Revolucionario, POR) became a mass party in the period of the late 1940s and early 1950s and together with other groups played a central role during and immediately after the period termed the Bolivian National Revolution.

In Brazil, as an officially recognised platform or faction of the PT until 1992, the Trotskyist Movimento Convergência Socialista (CS), which founded the United Socialist Workers' Party (PSTU) in 1994, saw a number of its members elected to national, state and local legislative bodies during the 1980s. The Socialism and Liberty Party (PSOL) presidential candidate in the 2006 general elections Heloísa Helena is termed a Trotskyist who was a member of the Workers Party of Brazil (PT), a legislative deputy in Alagoas and in 1999 was elected to the Federal Senate. Expelled from the PT in December 2003, she helped found PSOL in which various Trotskyist groups play a prominent role.

Workers' Left Front in Argentina in December 2017

In Argentina, the Workers' Revolutionary Party (Partido Revolucionario de los Trabajadores, PRT) lay in the merger of two leftist organizations in 1965, the Revolutionary and Popular Amerindian Front (Frente Revolucionario Indoamericano Popular, FRIP) and Worker's Word (Palabra Obrera, PO). In 1968, the PRT adhered to the Fourth International, based in Paris. That same year a related organisation was founded in Argentina, the ERP (People's Revolutionary Army) that became the strongest rural guerrilla movement in South America during the 1970s. The PRT left the Fourth International in 1973. Both the PRT and the ERP were suppressed by the Argentine military regime during the Dirty War. ERP commander Roberto Santucho was killed in July 1976. Owing to the ruthless repression PRT showed no signs of activity after 1977. During the 1980s in Argentina, the Trotskyist party founded in 1982 by Nahuel Moreno, MAS, (Movimiento al Socialismo, Movement Toward Socialism), claimed to be the "largest Trotskyist party" in the world before it broke into a number of different fragments in the late 1980s, including the present-day MST, PTS, Nuevo MAS, IS, PRS, FOS, etc. In 1989 in an electoral front with the Communist Party and Christian nationalists groups, called Izquierda Unida ("United Left"), obtained 3.49% of the vote, representing 580,944 voters. Today, the Workers' Party in Argentina has an electoral base in Salta Province in the far north, particularly in the city of Salta itself; and has become the third political force in the provinces of Tucumán, also in the north; and Santa Cruz, in the south.

Venezuelan president Hugo Chávez declared himself to be a Trotskyist during his swearing-in of his cabinet, two days before his own inauguration on 10 January 2007. Venezuelan Trotskyist organizations do not regard Chávez as a Trotskyist, with some describing him as a bourgeois nationalist and other considering him an honest revolutionary leader who has made major mistakes because he lacks a Marxist analysis.

Asia

LSSP main office in Colombo, Sri Lanka

In China various left opposition groups in the late 1920s sought to engage Trotsky against the Comintern policy of support for the Kuomintang. In 1931, at Trotsky's urging, the various factions united in the Communist League of China, adopting Trotsky’s document "The Political Situation in China and the Task of the Bolshevik-Leninist Opposition". The League and persecuted by the Nationalist government and by the Chinese Communist Party. 

In 1939, Ho Chi Minh, then a Comintern agent in southern China, reported that "everyone united to fight the Japanese except the Trotskyists. These traitors . . . adopted the ‘resolution’: ‘In the war against the Japanese, our position is clear: those who wanted the war and have illusions about the Kuomintang government, those concretely have committed treason. The union between the Communist Party and the Kuomintang is nothing but conscious treason’. And other ignominies of this kind." The Trotskyists were to be "crushed." In 1949, the Revolutionary Communist Party of China (Chinese: 中國革命共產黨; RCP) fled to Hong Kong. Since 1974, the party has been legally active as October Review, its official publication.

In French Indochina during the 1930s, Vietnamese Trotskyism led by Tạ Thu Thâu was a significant current, particularly in Saigon, Cochinchina. In 1929, in the French Left Opposition La Vérité, Ta Thu Thau had condemned the Comintern for leading Chinese Communists (in 1927) to "the graveyard" through its support for the Kuomintang. The "'Sun Yat-sen-ist' synthesis of democracy, nationalism and socialism" was "a kind of nationalist mysticism." In Indochina it could only obscure "the concrete class relationships, and the real, organic liaison between the indigenous bourgeoisie and French imperialism," in the light of which the call for independence is "mechanical and formalistic." "A revolution based on the organisation of the proletarian and peasant masses is the only one capable of liberating the colonies ... The question of independence must be bound up with that of the proletarian socialist revolution."

For a period in the 1930s Ta Thu Thau's Struggle group, centred around the newspaper La Lutte , was sufficiently strong to induce "Stalinists" (members of the then Indochinese Communist Party) to collaborate with the Trotskyists in support of labour and peasant struggles, and in the presentation of a common Workers Slate for Saigon municipal, and Cochinchina Council, elections. Ta Thu Thau was captured and executed by the Communist-front Viet Minh in September 1945. Many, if not most, of his fellow luttuers were subsequently killed caught between the Viet Minh and the French effort at colonial reconquest.

In Sri Lanka, a group of Trotskyists (known as the "T Group"), including South Asia's pioneer Trotskyist, Philip Gunawardena, who had been active in Trotskyist politics in Europe, and his colleague N. M. Perera, were instrumental in the foundation of the Lanka Sama Samaja Party (LSSP) in 1935. It expelled its pro-Moscow wing in 1940, becoming a Trotskyist-led party. In 1942, following the escape of the leaders of the LSSP from a British prison, a unified Bolshevik–Leninist Party of India, Ceylon and Burma (BLPI) was established in India, bringing together the many Trotskyist groups in the subcontinent. The BLPI was active in the Quit India Movement as well as the labour movement, capturing the second oldest union in India. Its high point was when it led the strikes which followed the Bombay Mutiny

After the war, the Sri Lanka section split into the Lanka Sama Samaja Party and the Bolshevik Samasamaja Party (BSP). In the general election of 1947, the LSSP became the main opposition party, winning 10 seats, the BSP winning a further 5. It joined the Trotskyist Fourth International after fusion with the BSP in 1950 and led a general strike (Hartal) in 1953.

In 1964, the LSSP joined in a coalition government with Sirimavo Bandaranaike, in which three of its members, NM Perera, Cholmondely Goonewardena and Anil Moonesinghe were brought into the new cabinet. This led to the expulsion of party from the Fourth International. A section of the LSSP split to form the LSSP (Revolutionary) and joined the Fourth International after the LSSP proper was expelled. The LSSP (Revolutionary) later split into factions led by Bala Tampoe and Edmund Samarakkody. A further faction, the "Sakthi" Group, led by V. Karalasingham, rejoined the LSSP in 1966.
In 1968, a further faction of the LSSP (Revolutionary), led by Keerthi Balasooriya split, to form the Revolutionary Socialist League - more commonly known as the "Kamkaru Mawatha Group", after the name of their publication - and joined the International Committee of the Fourth International (ICFI). In 1987, the group changed its name to Socialist Equality Party.




In 1974, a secret faction of the LSSP, allied to the Militant group in the United Kingdom emerged. In 1977, this faction was expelled and formed the Nava Sama Samaja Party, led by Vasudeva Nanayakkara. In India the BLPI fractured. In 1948, at the request of the Fourth International, the rump of the party dissolved into the Congress Socialist Party as an exercise in entryism.

Europe

LCR protesters marching in a workforce demonstration in favour of public services and against privatization
 
The French section of the Fourth International was the Internationalist Communist Party (PCI). In 1952 the party split when the Fourth International removed its Central Committee, and split again when in 1953 the Fourth International itself divided. Further divisions occurred over which independence faction to support in the Algerian War.

In 1967, the rump of the PCI renamed itself the "Internationalist Communist Organisation" (Organisation Communiste Internationaliste, OCI). It grew rapidly during the May 1968 student demonstrations, but was banned alongside other far left groups, such as the Gauche prolétarienne (Proletarian Left). Members temporarily reconstituted the group as the Trotskyist Organisation, but soon obtained a state order permitting the reformation of the OCI. By 1970, the OCI was able to organise a 10,000-strong youth rally. The group also gained a strong base in trade unions. But further splits and disintegration followed.

In 2016 Jean-Luc Mélenchon, formerly of the ICO, launched the left-wing political platform La France Insoumise' (Unbowed France) subsequently endorsed by several parties, including his own Left Party and the French Communist Party. In the 2017 French Presidential Election he received 19% in the first round.' In the same election, Philippe Poutou of the New Anticapitalist Party, into which the Revolutionary Communist League (Ligue communiste révolutionnaire) dissolved itself in 2008, won 1.20% of the vote. The only openly Trotskyist candidate, Nathalie Arthaud of Workers' Struggle (Lutte Ouvrière) won 0.64% of the vote.

In Britain during the 1980s, the entryist Militant group operated within the Labour Party with three Members of Parliament and effective control of Liverpool City Council. Described by journalist Michael Crick as "Britain's fifth most important political party" in 1986, it played a prominent role in the 1989–1991 anti-poll tax movement which was widely thought to have led to the downfall of British Prime Minister Margaret Thatcher.

The most enduring of several Trotskyist parties in Britain has been the Socialist Workers Party, formerly the International Socialists (IS). Its founder Tony Cliff rejected the orthodox Trotskyist view of the USSR as a "deformed worker's state." Communist-party regimes were "state capitalist." The SWP has founded several front organisations through which they have sought to exert influence over the wider left, such as the Anti-Nazi League in the late 1970s and the Stop the War Coalition in 2001. It also formed an alliance with George Galloway and Respect whose dissolution in 2007 caused an internal crisis in the SWP. A more serious internal crisis, leading to a significant decline in the party's membership, emerged in 2013. Allegations of rape and sexual assault made against a leading member of the party, developed into a dispute over the practice of democratic centralism (defended by the party's international secretary Alex Callinicos).

In April 2019, a rival splinter from IS made headlines when three former members of the Revolutionary Communist Party campaigned in the European Parliamentary election as candidates for the Brexit Party, and a fourth, Munira Mirza, was appointed head of the Number 10 [Downing Street] policy unit by the new Conservative Prime Minister Boris Johnson. The RCP's rejection of the SWP's critical engagement with the Labour Party and with trade unions had morphed into an embrace of right-wing libertarian positions.

The Socialist Party in Ireland was formed in 1990 by members who had been expelled by the Irish Labour Party's leader Dick Spring. It has had support in the Fingal electoral district as well as in the city of Limerick. In 2018, it had three elected officials in Dáil Éireann. Paul Murphy, representing Dublin West (Dáil constituency), Mick Barry representing Cork North-Central (Dáil constituency) and Ruth Coppinger representing Dublin West (Dáil constituency).

In Portugal's October 2015 parliamentary election, the Left Bloc won 550,945 votes, which translated into 10.19% of the expressed votes and the election of 19 (out of 230) deputados (members of parliament). Although founded by several leftist tendencies, it still expresses much of the Trotskyist thought upheld and developed by its former leader, Francisco Louçã.

In Turkey, there are some Trotskyist organizations, including the International Socialist Tendency's section (Revolutionary Workers' Socialist Party), Coordinating Committee for the Refoundation of the Fourth International's section (Revolutionary Workers' Party), Permanent Revolution Movement (SDH), Socialism Magazine (sympathizers of the International Committee of the Fourth International), and several small groups.

International

Socialist Alternative members in the United States at an antiwar march in 2007

The Fourth International derives from the 1963 reunification of the two public factions into which the Fourth International split in 1953: the International Secretariat of the Fourth International (ISFI) and some sections of the International Committee of the Fourth International (ICFI). It is often referred to as the United Secretariat of the Fourth International, the name of its leading committee before 2003. The USFI retains sections and sympathizing organizations in over 50 countries, including the Ligue Communiste Revolutionnaire (LCR) of France, as well as sections in Portugal, Sri Lanka, the Philippines, and Pakistan.

The International Committee of the Fourth International maintains its independent organization and publishes the World Socialist Web Site.

The Committee for a Workers' International (CWI) was founded in 1974 and now has sections in over 35 countries. Before 1997, most organisations affiliated to the CWI sought to build an entrist Marxist wing within the large social democratic parties. The CWI has adopted a range of tactics, including working with trade unions, but in some cases working within or supporting other parties, endorsing Bernie Sanders for the 2016 U.S. Democratic Party nomination and encouraging him to run independently.
In France, the LCR is rivalled by Lutte Ouvrière, the French section of the Internationalist Communist Union (UCI), with small sections in a handful of other countries. It focuses its activities, whether propaganda or intervention, within the industrial proletariat.

The founders of the Committee for a Marxist International (CMI) claim they were expelled from the CWI when the CWI abandoned entryism. The CWI claims they left and no expulsions were carried out. Since 2006, it has been known as the International Marxist Tendency (IMT). CMI/IMT groups continue the policy of entering mainstream social democratic, communist or radical parties. Currently, International Marxist Tendency (IMT) is headed by Alan Woods

The list of Trotskyist internationals shows that there are a large number of other multinational tendencies that stand in the tradition of Leon Trotsky.

Criticism

Trotskyism has been criticised from various directions. In 1935, Marxist–Leninist Moissaye J. Olgin argued that Trotskyism was "the enemy of the working class" and "should be shunned by anybody who has sympathy for the revolutionary movement of the exploited and oppressed the world over." The African American Marxist–Leninist Harry Haywood, who spent much time in the Soviet Union during the 1920s and 1930s, stated that although he had been somewhat interested in Trotsky’s ideas when he was young, he came to see it as "a disruptive force on the fringes of the international revolutionary movement" which eventually developed into "a counter-revolutionary conspiracy against the Party and the Soviet state". He continued to put forward his following belief:
Trotsky was not defeated by bureaucratic decisions or Stalin's control of the Party apparatus—as his partisans and Trotskyite historians claim. He had his day in court and finally lost because his whole position flew in the face of Soviet and world realities. He was doomed to defeat because his ideas were incorrect and failed to conform to objective conditions, as well as the needs and interests of the Soviet people.
Other figures associated with Marxism-Leninism criticized Trotskyist political theory, including Régis Debray. and Earl Browder.

Polish philosopher Leszek Kołakowski wrote: "Both Trotsky and Bukharin were emphatic in their assurances that forced labour was an organic part of the new society."

The way Trotskyists organise to promote their beliefs has been criticised often by ex-members of their organisations. Dennis Tourish, a former member of the CWI, asserts that these organisations typically value doctrinal orthodoxy over critical reflection, have illusions in the absolute correctness of their own party's analysis, a fear of dissent, the demonising of dissenters and critical opinion, overworking of members, a sectarian attitude to the rest of the left and the concentration of power among a small group of leaders.

Some Left Communists such as Paul Mattick claim that the October Revolution was totalitarian from the start and therefore Trotskyism has no real differences from Stalinism either in practice or theory.

In the United States, Dwight Macdonald broke with Trotsky and left the Trotskyist Socialist Workers Party by raising the question of the Kronstadt rebellion, which Trotsky as leader of the Soviet Red Army and the other Bolsheviks had brutally repressed. He then moved towards democratic socialism and anarchism. A similar critique on Trotsky's role on the events around the Kronstadt rebellion was raised by the American anarchist Emma Goldman. In her essay "Trotsky Protests Too Much", she says: "I admit, the dictatorship under Stalin's rule has become monstrous. That does not, however, lessen the guilt of Leon Trotsky as one of the actors in the revolutionary drama of which Kronstadt was one of the bloodiest scenes". Trotsky defended the actions of the Red Army in his essay "Hue and Cry over Kronstadt".

Bolsheviks

From Wikipedia, the free encyclopedia


The Bolsheviks, also known in English as the Bolshevists, were a radical far-left Marxist faction founded by Vladimir Lenin and Alexander Bogdanov that split from the Menshevik faction of the Marxist Russian Social Democratic Labour Party (RSDLP), a revolutionary socialist political party formed in 1898, at its Second Party Congress in 1903.

After forming their own party in 1912, the Bolsheviks took power in Russia in November 1917, overthrowing the liberal Provisional Government of Alexander Kerensky, and became the only ruling party in the subsequent Soviet Russia and its successor state, the Soviet Union. They considered themselves the leaders of the revolutionary working class of Russia. Their beliefs and practices were often referred to as Bolshevism.

History of the split

Lenin's ideology in What Is to Be Done?

Bolshevik, Boris Kustodiev, 1920

Lenin's political pamphlet What Is to Be Done?, which Lenin wrote in 1901 and published in 1902, helped to precipitate the split. In Germany, the book was published in 1902; but in Russia, strict censorship outlawed its publication and distribution. One of the main points of Lenin's writing was that a revolution can only be achieved by the strong leadership of the masses by one person, or by a very select few, who would dedicate their entire lives to the cause, although after the proposed revolution had successfully overthrown the government, this strong leadership would relinquish power to allow socialism to fully develop. Lenin said that if professional revolutionaries did not maintain control over the workers, then they would lose sight of the party's objective and adopt opposing beliefs, even abandon the revolution entirely.

The pamphlet also showed that Lenin's view of a socialist intelligentsia was not in line with Marxist theory, which also created some party unrest. For example, Lenin agreed with the Marxist idea of eliminating social classes, but his vision of a future society encompassed visible distinctions between those in politics and the common worker. Most party members considered unequal treatment of workers immoral and were loyal to the idea of a completely classless society. This pamphlet also showed that Lenin opposed another group of reformers, known as "Economists", who were for economic reform while leaving the government relatively unchanged and who, in Lenin's view, failed to recognize the importance of uniting the working population behind the party's cause.

2nd party congress

At the 2nd Congress of the RSDLP, which was held in Brussels and then London during August 1903, Lenin and Julius Martov disagreed over the party membership rules. Lenin, who was supported by Plekhanov, wanted to limit membership to those who supported the party full-time and worked in complete obedience to the elected party leadership. Martov wanted to extend membership to anyone "who recognises the Party Programme and supports it by material means and by regular personal assistance under the direction of one of the party’s organisations". Lenin believed his plan would develop a core group of professional revolutionaries who would devote their full time and energy towards developing the party into an organization capable of leading a successful workers' revolution against the Tsarist autocracy.

The base of active and experienced members would be the recruiting ground for this professional core. Sympathizers would be left outside and the party would be organised based on the concept of democratic centralism. Martov, until then a close friend of Lenin, agreed with him that the core of the party should consist of professional revolutionaries, but he argued that party membership should be open to sympathizers, revolutionary workers, and other fellow travellers. The two had disagreed on the issue as early as March–May 1903, but it was not until the Congress that their differences became irreconcilable and split the party. At first, the disagreement appeared to be minor and inspired by personal conflicts. For example, Lenin's insistence on dropping less active editorial board members from Iskra or Martov's support for the Organizing Committee of the Congress which Lenin opposed. The differences grew and the split became irreparable.

Internal unrest also arose over the political structure that was best suited for Soviet power. As discussed in What Is To Be Done?, Lenin firmly believed that a rigid political structure was needed to effectively initiate a formal revolution. This idea was met with opposition from once close followers, including Martov, Georgy Plekhanov, Leon Trotsky, and Pavel Axelrod. Plekhanov and Lenin's major dispute arose addressing the topic of nationalizing land or leaving it for private use. Lenin wanted to nationalize to aid in collectivization whereas Plekhanov thought worker motivation would remain higher if individuals were able to maintain their own property. Those who opposed Lenin and wanted to continue on the Marxist path towards complete socialism and disagreed with his strict party membership guidelines became known as "softs" while Lenin supporters became known as "hards".

Some of the factionalism could be attributed to Lenin's steadfast belief in his own opinion and what was described by Plekhanov as Lenin's inability to "bear opinions which were contrary to his own" and loyalty to his own self-envisioned utopia. Lenin was seen even by fellow party members as being so narrow-minded and unable to accept criticism that he believed that anyone who didn't follow him was his enemy. Leon Trotsky, one of Lenin's fellow revolutionaries, compared Lenin in 1904 to the French revolutionary Maximilien Robespierre.

Origins of Bolshevik and Menshevik

The two factions were originally known as "hard" (Lenin's supporters) and "soft" (Martov's supporters), but the terminology soon changed to "Bolsheviks" and "Mensheviks", from the Russian bolshinstvo ("majority") and menshinstvo ("minority"). In the Second Party Congress vote, the Bolsheviks won votes on the majority of important issues, hence the name. On the other hand, Martov's supporters won the vote concerning the question of party membership. Neither Lenin nor Martov had a firm majority throughout the Congress as delegates left or switched sides. In the end, the Congress was evenly split between the two factions.

From 1907 on, English language articles sometimes used the term "Maximalist" for "Bolshevik" and "Minimalist" for "Menshevik", which proved confusing since there was also a "Maximalist" faction within the Russian Socialist Revolutionary Party in 1904–1906 (which after 1906 formed a separate Union of Socialists-Revolutionaries Maximalists) and then again after 1917.

The Bolsheviks ultimately became the Communist Party of the Soviet Union. The Bolsheviks, or Reds, came to power in Russia during the October Revolution phase of the Russian Revolution of 1917 and founded the Russian Soviet Federative Socialist Republic (RSFSR). With the Reds defeating the Whites and others during the Russian Civil War of 1917–1922, the RSFSR became the chief constituent of the Soviet Union (USSR) in December 1922.

Demographics of the two factions

The average party member was very young. In 1907, 22% of Bolsheviks were under 20, 37% were 20–24 and 16% were 25–29. By 1905, 62% of the members were industrial workers (3% of the population in 1897). 22% of Bolsheviks were gentry (1.7% of the total population), 38% were uprooted peasants, compared with 19% and 26% for the Mensheviks. In 1907, 78.3% of the Bolsheviks were Russian and 10% were Jewish (34% and 20% for the Mensheviks). Total membership was 8,400 in 1905, 13,000 in 1906 and 46,100 by 1907 (8,400, 18,000 and 38,200 for the Mensheviks). By 1910, both factions together had fewer than 100,000 members.

Beginning of the 1905 Revolution (1903–1905)

The two factions were in a state of flux in 1903–1904 with many members changing sides. The founder of Russian Marxism, Georgy Plekhanov, who at first allied himself with Lenin and the Bolsheviks, had parted ways with them by 1904. Trotsky at first supported the Mensheviks, but he left them in September 1904 over their insistence on an alliance with Russian liberals and their opposition to a reconciliation with Lenin and the Bolsheviks. He remained a self-described "non-factional social democrat" until August 1917, when he joined Lenin and the Bolsheviks, as their positions resembled his and he came to believe that Lenin was right on the issue of the party.

All but one member of the RSDLP Central Committee were arrested in Moscow in early 1905. The remaining member, with the power of appointing a new committee, was won over by the Bolsheviks.

The lines between the Bolsheviks and the Mensheviks hardened in April 1905 when the Bolsheviks held a Bolsheviks-only meeting in London, which they called the 3rd Party Congress. The Mensheviks organised a rival conference and the split was thus finalized.

The Bolsheviks played a relatively minor role in the 1905 Revolution and were a minority in the Saint Petersburg Soviet of Workers' Deputies led by Trotsky. However, the less significant Moscow Soviet was dominated by the Bolsheviks. These Soviets became the model for those formed in 1917.

Mensheviks (1906–1907)

As the Russian Revolution of 1905 progressed, Bolsheviks, Mensheviks, and smaller non-Russian social democratic parties operating within the Russian Empire attempted to reunify at the 4th (Unification) Congress of the RSDLP held in April 1906 at Folkets hus, Norra Bantorget, in Stockholm. When the Mensheviks made an alliance with the Jewish Bund, the Bolsheviks found themselves in a minority.

However, all factions retained their respective factional structure and the Bolsheviks formed the Bolshevik Centre, the de facto governing body of the Bolshevik faction within the RSDLP. At the Fifth Congress held in London in May 1907, the Bolsheviks were in the majority, but the two factions continued functioning mostly independently of each other.

Split between Lenin and Bogdanov (1908–1910)

Tensions had existed between Lenin and Alexander Bogdanov from as early as 1904. Lenin had fallen out with Nikolai Valentinov after Valentinov had introduced him to Ernst Mach's Empiriocriticism, a viewpoint that Bogdanov had been exploring and developing as Empiriomonism. Having worked as co-editor with Plekhanov on Zarya, Lenin had come to agree with the Valentinov's rejection of Bogdanov's Empiriomonism. With the defeat of the revolution in mid-1907 and the adoption of a new, highly restrictive election law, the Bolsheviks began debating whether to boycott the new parliament known as the Third Duma. Lenin, Grigory Zinoviev, Lev Kamenev, and others argued for participating in the Duma while Bogdanov, Anatoly Lunacharsky, Mikhail Pokrovsky, and others argued that the social democratic faction in the Duma should be recalled. The latter became known as "recallists" (otzovists in Russian). A smaller group within the Bolshevik faction demanded that the RSDLP central committee should give its sometimes unruly Duma faction an ultimatum, demanding complete subordination to all party decisions. This group became known as "ultimatists" and was generally allied with the recallists.

With most Bolshevik leaders either supporting Bogdanov or undecided by mid-1908 when the differences became irreconcilable, Lenin concentrated on undermining Bogdanov's reputation as a philosopher. In 1909, he published a scathing book of criticism entitled Materialism and Empirio-criticism (1909), assaulting Bogdanov's position and accusing him of philosophical idealism. In June 1909, Bogdanov proposed the formation of Party Schools as Proletarian Universities at a Bolshevik mini-conference in Paris organised by the editorial board of the Bolshevik magazine Proletary. However, this proposal was not adopted and Lenin tried to expel Bogdanov from the Bolshevik faction. Bogdanov was then involved with setting up Vpered, which ran the Capri Party School from August to December 1909.

Final attempt at party unity (1910)

With both Bolsheviks and Mensheviks weakened by splits within their ranks and by Tsarist repression, the two factions were tempted to try to re-unite the party. In January 1910, Leninists, recallists, and various Menshevik factions held a meeting of the party's Central Committee in Paris. Kamenev and Zinoviev were dubious about the idea; but under pressure from conciliatory Bolsheviks like Victor Nogin, they were willing to give it a try.

One of the underlying reasons that prevented any reunification of the party was the Russian police. The police were able to infiltrate both parties' inner circles by sending in spies who then reported on the opposing party's intentions and hostilities. This allowed the tensions to remain high between the Bolsheviks and Mensheviks and helped prevent their uniting. 

Lenin was firmly opposed to any re-unification but was outvoted within the Bolshevik leadership. The meeting reached a tentative agreement, and one of its provisions was to make Trotsky's Vienna-based Pravda a party-financed central organ. Kamenev, Trotsky's brother-in-law who was with the Bolsheviks, was added to the editorial board; but the unification attempts failed in August 1910 when Kamenev resigned from the board amid mutual recriminations.

Forming a separate party (1912)


The factions permanently broke relations in January 1912 after the Bolsheviks organised a Bolsheviks-only Prague Party Conference and formally expelled Mensheviks and recallists from the party. As a result, they ceased to be a faction in the RSDLP and instead declared themselves an independent party, called Russian Social Democratic Labour Party (Bolsheviks) – or RSDLP(b). Unofficially, the party has been referred to as the Bolshevik Party. Throughout the 20th century, the party adopted a number of different names. In 1918, RSDLP(b) became All-Russian Communist Party (Bolsheviks) and remained so until 1925. From 1925–1952, the name was All-Union Communist Party (Bolsheviks) and from 1952–1991 Communist Party of the Soviet Union

As the party split became permanent, further divisions became evident. One of the most notable differences was how each faction decided to fund its revolution. The Mensheviks decided to fund their revolution through membership dues while Lenin often resorted to more drastic measures since he required a higher budget. One of the common methods the Bolsheviks used was committing bank robberies, one of which, in 1907, resulted in the party getting over 250,000 roubles, which is the equivalent of about $125,000. Bolsheviks were in constant need of money because Lenin practised his beliefs, expressed in his writings, that revolutions must be led by individuals who devote their entire lives to the cause. As compensation, he rewarded them with salaries for their sacrifice and dedication. This measure was taken to help ensure that the revolutionaries stayed focused on their duties and motivated them to perform their jobs. Lenin also used the party money to print and copy pamphlets which were distributed in cities and at political rallies in an attempt to expand their operations. Both factions received funds through donations from wealthy supporters.

The elections to the Russian Constituent Assembly took place in November 1917 in which the Bolsheviks came second with 23.9% of the vote and dissolved the Assembly in January 1918
 
Further differences in party agendas became evident as the beginning of World War I loomed near. Joseph Stalin was especially eager for the start of the war, hoping that it would turn into a war between classes or essentially a Russian Civil War. This desire for war was fuelled by Lenin's vision that the workers and peasants would resist joining the war effort and therefore be more compelled to join the socialist movement. Through the increase in support, Russia would then be forced to withdraw from the Allied powers in order to resolve her internal conflict. Unfortunately for the Bolsheviks, Lenin's assumptions were incorrect. Despite his and the party's attempts to push for a civil war through involvement in two conferences in 1915 and 1916 in Switzerland, the Bolsheviks were in the minority in calling for a ceasefire by the Russian Army in World War I.

Although the Bolshevik leadership had decided to form a separate party, convincing pro-Bolshevik workers within Russia to follow suit proved difficult. When the first meeting of the Fourth Duma was convened in late 1912, only one out of six Bolshevik deputies, Matvei Muranov (another one, Roman Malinovsky, was later exposed as an Okhrana agent), voted on 15 December 1912 to break from the Menshevik faction within the Duma. The Bolshevik leadership eventually prevailed, and the Bolsheviks formed their own Duma faction in September 1913.

One final difference between the Bolsheviks and Mensheviks was how ferocious and tenacious the Bolshevik party was in order to achieve its goals, although Lenin was open minded to retreating from political ideals if he saw the guarantee of long-term gains benefiting the party. This practice was seen in the party's trying to recruit peasants and uneducated workers by promising them how glorious life would be after the revolution and granting them temporary concessions.

In 1918, the party renamed itself the Russian Communist Party (Bolsheviks) at Lenin's suggestion. In 1925, this was changed to All-Union Communist Party (Bolsheviks). At the 19th Party Congress in 1952 the Bolshevik Party was renamed the Communist Party of the Soviet Union at Stalin's suggestion.

Non-Russian/Soviet groups having used the name "Bolshevik"

Derogatory usage of "Bolshevik"

"Down with Bolshevism. Bolshevism brings war and destruction, hunger and death", anti-Bolshevik German propaganda, 1919
 
"Bolo" was a derogatory expression for Bolsheviks used by British service personnel in the North Russian Expeditionary Force which intervened against the Red Army during the Russian Civil War. Adolf Hitler, Joseph Goebbels and other Nazi leaders used it in reference to the worldwide political movement coordinated by the Comintern. During the days of the Cold War in the United Kingdom, labour union leaders and other leftists were sometimes derisively described as "Bolshies". The usage is roughly equivalent to the term "commie", "Red", or "pinko" in the United States during the same period. The term "Bolshie" later became a slang term for anyone who was rebellious, aggressive, or truculent.

Wednesday, June 24, 2020

Coagulation

From Wikipedia, the free encyclopedia

Coagulation
Coagulation in vivo.png
Blood coagulation pathways in vivo showing the central role played by thrombin
HealthBeneficial

Coagulation, also known as clotting, is the process by which blood changes from a liquid to a gel, forming a blood clot. It potentially results in hemostasis, the cessation of blood loss from a damaged vessel, followed by repair. The mechanism of coagulation involves activation, adhesion and aggregation of platelets, as well as deposition and maturation of.

Coagulation begins almost instantly after an injury to the blood vessel has damaged the endothelium lining the blood vessel. Exposure of blood to the subendothelial space initiates two processes: changes in platelets, and the exposure of subendothelial tissue factor to plasma factor VII, which ultimately leads to cross-linked fibrin formation. Platelets immediately form a plug at the site of injury; this is called primary hemostasis. Secondary hemostasis occurs simultaneously: additional coagulation (clotting) factors beyond factor VII  respond in a cascade to form fibrin strands, which strengthen the platelet plug.

Disorders of coagulation are disease states which can result in hemorrhage, bruising, or thrombosis.

Coagulation is highly conserved throughout biology. In all mammals, coagulation involves both a cellular (platelet) and a protein (coagulation factor) component. The system in humans has been the most extensively researched and is the best understood.

Physiology

The interaction of vWF and GP1b alpha. The GP1b receptor on the surface of platelets allows the platelet to bind to vWF, which is exposed upon damage to vasculature. The vWF A1 domain (yellow) interacts with the extracellular domain of GP1ba (blue).

Platelet activation

When the endothelium is damaged, the normally isolated, underlying collagen is exposed to circulating platelets, which bind directly to collagen with collagen-specific glycoprotein Ia/IIa surface receptors. This adhesion is strengthened further by von Willebrand factor (vWF), which is released from the endothelium and from platelets; vWF forms additional links between the platelets' glycoprotein Ib/IX/V and A1 domain. This localization of platelets to the extracellular matrix promotes collagen interaction with platelet glycoprotein VI. Binding of collagen to glycoprotein VI triggers a signaling cascade that results in activation of platelet integrins. Activated integrins mediate tight binding of platelets to the extracellular matrix. This process adheres platelets to the site of injury.

Activated platelets release the contents of stored granules into the blood plasma. The granules include ADP, serotonin, platelet-activating factor (PAF), vWF, platelet factor 4, and thromboxane A2 (TXA2), which, in turn, activate additional platelets. The granules' contents activate a Gq-linked protein receptor cascade, resulting in increased calcium concentration in the platelets' cytosol. The calcium activates protein kinase C, which, in turn, activates phospholipase A2 (PLA2). PLA2 then modifies the integrin membrane glycoprotein IIb/IIIa, increasing its affinity to bind fibrinogen. The activated platelets change shape from spherical to stellate, and the fibrinogen cross-links with glycoprotein IIb/IIIa aid in aggregation of adjacent platelets (completing primary hemostasis).

Coagulation cascade

The classical blood coagulation pathway
 
Modern coagulation pathway. Hand-drawn composite from similar drawings presented by Professor Dzung Le, MD, PhD, at UCSD Clinical Chemistry conferences on 14 and 21 October 2014. Original schema from Introduction to Hematology by Samuel I. Rapaport. 2nd edition;Lippencott:1987. Dr Le added the factor XI portion based on a paper from about year 2000. Dr. Le's similar drawings presented the development of this cascade over 6 frames, like a comic.
 
The coagulation cascade of secondary hemostasis has two initial pathways which lead to fibrin formation. These are the contact activation pathway (also known as the intrinsic pathway), and the tissue factor pathway (also known as the extrinsic pathway), which both lead to the same fundamental reactions that produce fibrin. It was previously thought that the two pathways of coagulation cascade were of equal importance, but it is now known that the primary pathway for the initiation of blood coagulation is the tissue factor (extrinsic) pathway. The pathways are a series of reactions, in which a zymogen (inactive enzyme precursor) of a serine protease and its glycoprotein co-factor are activated to become active components that then catalyze the next reaction in the cascade, ultimately resulting in cross-linked fibrin. Coagulation factors are generally indicated by Roman numerals, with a lowercase a appended to indicate an active form.

The coagulation factors are generally serine proteases (enzymes), which act by cleaving downstream proteins. The exceptions are tissue factor, FV, FVIII, FXIII. Tissue factor, FV and FVIII are glycoproteins, and Factor XIII is a transglutaminase. The coagulation factors circulate as inactive zymogens. The coagulation cascade is therefore classically divided into three pathways. The tissue factor and contact activation pathways both activate the "final common pathway" of factor X, thrombin and fibrin.

Tissue factor pathway (extrinsic)

The main role of the tissue factor pathway is to generate a "thrombin burst", a process by which thrombin, the most important constituent of the coagulation cascade in terms of its feedback activation roles, is released very rapidly. FVIIa circulates in a higher amount than any other activated coagulation factor. The process includes the following steps:
  1. Following damage to the blood vessel, FVII leaves the circulation and comes into contact with tissue factor (TF) expressed on tissue-factor-bearing cells (stromal fibroblasts and leukocytes), forming an activated complex (TF-FVIIa).
  2. TF-FVIIa activates FIX and FX.
  3. FVII is itself activated by thrombin, FXIa, FXII and FXa.
  4. The activation of FX (to form FXa) by TF-FVIIa is almost immediately inhibited by tissue factor pathway inhibitor (TFPI).
  5. FXa and its co-factor FVa form the prothrombinase complex, which activates prothrombin to thrombin.
  6. Thrombin then activates other components of the coagulation cascade, including FV and FVIII (which forms a complex with FIX), and activates and releases FVIII from being bound to vWF.
  7. FVIIIa is the co-factor of FIXa, and together they form the "tenase" complex, which activates FX; and so the cycle continues. ("Tenase" is a contraction of "ten" and the suffix "-ase" used for enzymes.)

Contact activation pathway (intrinsic)

The contact activation pathway begins with formation of the primary complex on collagen by high-molecular-weight kininogen (HMWK), prekallikrein, and FXII (Hageman factor). Prekallikrein is converted to kallikrein and FXII becomes FXIIa. FXIIa converts FXI into FXIa. Factor XIa activates FIX, which with its co-factor FVIIIa form the tenase complex, which activates FX to FXa. The minor role that the contact activation pathway has in initiating clot formation can be illustrated by the fact that patients with severe deficiencies of FXII, HMWK, and prekallikrein do not have a bleeding disorder. Instead, contact activation system seems to be more involved in inflammation, and innate immunity. Despite this, interference with the pathway may confer protection against thrombosis without a significant bleeding risk.

Final common pathway

The division of coagulation in two pathways is arbitrary, originating from laboratory tests in which clotting times were measured either after the clotting was initiated by glass, the intrinsic pathway; or clotting was initiated by thromboplastin (a mix of tissue factor and phospholipids), the extrinsic pathway.

Further, the final common pathway scheme implies that prothrombin is converted to thrombin only when acted upon by the intrinsic or extrinsic pathways, which is an oversimplification. In fact, thrombin is generated by activated platelets at the initiation of the platelet plug, which in turn promotes more platelet activation.

Thrombin functions not only to convert fibrinogen to fibrin, it also activates Factors VIII and V and their inhibitor protein C (in the presence of thrombomodulin); and it activates Factor XIII, which forms covalent bonds that crosslink the fibrin polymers that form from activated monomers.

The coagulation cascade is maintained in a prothrombotic state by the continued activation of FVIII and FIX to form the tenase complex until it is down-regulated by the anticoagulant pathways.

Cell-based scheme of coagulation

A newer model of coagulation mechanism explains the intricate combination of cellular and biochemical events that occur during the coagulation process in vivo. Along with the procoagulant and anticoagulant plasma proteins, normal physiologic coagulation requires the presence of two cell types for formation of coagulation complexes: cells that express tissue factor (usually extravascular) and platelets.

The coagulation process occurs in two phases. First is the initiation phase, which occurs in tissue-factor-expressing cells. This is followed by the propagation phase, which occurs on activated platelets. The initiation phase, mediated by the tissue factor exposure, proceeds via the classic extrinsic pathway and contributes to about 5% of thrombin production. The amplified production of thrombin occurs via the classic intrinsic pathway in the propagation phase; about 95% of thrombin generated will be during this second phase.

Cofactors

Various substances are required for the proper functioning of the coagulation cascade:

Calcium and phospholipid

Calcium and phospholipid (a platelet membrane constituent) are required for the tenase and prothrombinase complexes to function. Calcium mediates the binding of the complexes via the terminal gamma-carboxy residues on FXa and FIXa to the phospholipid surfaces expressed by platelets, as well as procoagulant microparticles or microvesicles shed from them. Calcium is also required at other points in the coagulation cascade.

Vitamin K

Vitamin K is an essential factor to a hepatic gamma-glutamyl carboxylase that adds a carboxyl group to glutamic acid residues on factors II, VII, IX and X, as well as Protein S, Protein C and Protein Z. In adding the gamma-carboxyl group to glutamate residues on the immature clotting factors, Vitamin K is itself oxidized. Another enzyme, Vitamin K epoxide reductase (VKORC), reduces vitamin K back to its active form. Vitamin K epoxide reductase is pharmacologically important as a target of anticoagulant drugs warfarin and related coumarins such as acenocoumarol, phenprocoumon, and dicumarol. These drugs create a deficiency of reduced vitamin K by blocking VKORC, thereby inhibiting maturation of clotting factors. Vitamin K deficiency from other causes (e.g., in malabsorption) or impaired vitamin K metabolism in disease (e.g., in liver failure) lead to the formation of PIVKAs (proteins formed in vitamin K absence), which are partially or totally non-gamma carboxylated, affecting the coagulation factors' ability to bind to phospholipid.

Regulators

Coagulation with arrows for negative and positive feedback.
 
Five mechanisms keep platelet activation and the coagulation cascade in check. Abnormalities can lead to an increased tendency toward thrombosis:

Protein C

Protein C is a major physiological anticoagulant. It is a vitamin K-dependent serine protease enzyme that is activated by thrombin into activated protein C (APC). Protein C is activated in a sequence that starts with Protein C and thrombin binding to a cell surface protein thrombomodulin. Thrombomodulin binds these proteins in such a way that it activates Protein C. The activated form, along with protein S and a phospholipid as cofactors, degrades FVa and FVIIIa. Quantitative or qualitative deficiency of either (protein C or protein S) may lead to thrombophilia (a tendency to develop thrombosis). Impaired action of Protein C (activated Protein C resistance), for example by having the "Leiden" variant of Factor V or high levels of FVIII, also may lead to a thrombotic tendency.

Antithrombin

Antithrombin is a serine protease inhibitor (serpin) that degrades the serine proteases: thrombin, FIXa, FXa, FXIa, and FXIIa. It is constantly active, but its adhesion to these factors is increased by the presence of heparan sulfate (a glycosaminoglycan) or the administration of heparins (different heparinoids increase affinity to FXa, thrombin, or both). Quantitative or qualitative deficiency of antithrombin (inborn or acquired, e.g., in proteinuria) leads to thrombophilia.

Tissue factor pathway inhibitor (TFPI)

Tissue factor pathway inhibitor (TFPI) limits the action of tissue factor (TF). It also inhibits excessive TF-mediated activation of FVII and FX.

Plasmin

Plasmin is generated by proteolytic cleavage of plasminogen, a plasma protein synthesized in the liver. This cleavage is catalyzed by tissue plasminogen activator (t-PA), which is synthesized and secreted by endothelium. Plasmin proteolytically cleaves fibrin into fibrin degradation products that inhibit excessive fibrin formation.

Prostacyclin

Prostacyclin (PGI2) is released by endothelium and activates platelet Gs protein-linked receptors. This, in turn, activates adenylyl cyclase, which synthesizes cAMP. cAMP inhibits platelet activation by decreasing cytosolic levels of calcium and, by doing so, inhibits the release of granules that would lead to activation of additional platelets and the coagulation cascade.

Fibrinolysis

Eventually, blood clots are reorganised and resorbed by a process termed fibrinolysis. The main enzyme responsible for this process (plasmin) is regulated by various activators and inhibitors.

Role in immune system

The coagulation system overlaps with the immune system. Coagulation can physically trap invading microbes in blood clots. Also, some products of the coagulation system can contribute to the innate immune system by their ability to increase vascular permeability and act as chemotactic agents for phagocytic cells. In addition, some of the products of the coagulation system are directly antimicrobial. For example, beta-lysine, an amino acid produced by platelets during coagulation, can cause lysis of many Gram-positive bacteria by acting as a cationic detergent. Many acute-phase proteins of inflammation are involved in the coagulation system. In addition, pathogenic bacteria may secrete agents that alter the coagulation system, e.g. coagulase and streptokinase.

Assessment

Numerous tests are used to assess the function of the coagulation system:
The contact activation (intrinsic) pathway is initiated by activation of the "contact factors" of plasma, and can be measured by the activated partial thromboplastin time (aPTT) test. 

The tissue factor (extrinsic) pathway is initiated by release of tissue factor (a specific cellular lipoprotein), and can be measured by the prothrombin time (PT) test. PT results are often reported as ratio (INR value) to monitor dosing of oral anticoagulants such as warfarin

The quantitative and qualitative screening of fibrinogen is measured by the thrombin clotting time (TCT). Measurement of the exact amount of fibrinogen present in the blood is generally done using the Clauss method for fibrinogen testing. Many analysers are capable of measuring a "derived fibrinogen" level from the graph of the Prothrombin time clot.

If a coagulation factor is part of the contact activation or tissue factor pathway, a deficiency of that factor will affect only one of the tests: Thus hemophilia A, a deficiency of factor VIII, which is part of the contact activation pathway, results in an abnormally prolonged aPTT test but a normal PT test. The exceptions are prothrombin, fibrinogen, and some variants of FX that can be detected only by either aPTT or PT. If an abnormal PT or aPTT is present, additional testing will occur to determine which (if any) factor is present as aberrant concentrations.

Deficiencies of fibrinogen (quantitative or qualitative) will affect all screening tests.

Role in disease

Coagulation defects may cause hemorrhage or thrombosis, and occasionally both, depending on the nature of the defect.

The GP1b-IX receptor complex. This protein receptor complex is found on the surface of platelets, and in conjunction with GPV allows for platelets to adhere to the site of injury. Mutations in the genes associated with the glycoprotein Ib-IX-V complex are characteristic of Bernard–Soulier syndrome

Platelet disorders

Platelet disorders are either congenital or acquired. Examples of congenital platelet disorders are Glanzmann's thrombasthenia, Bernard–Soulier syndrome (abnormal glycoprotein Ib-IX-V complex), gray platelet syndrome (deficient alpha granules), and delta storage pool deficiency (deficient dense granules). Most are rare. They predispose to hemorrhage. Von Willebrand disease is due to deficiency or abnormal function of von Willebrand factor, and leads to a similar bleeding pattern; its milder forms are relatively common.

Decreased platelet numbers (thrombocytopenia) is due to insufficient production (e.g., myelodysplastic syndrome or other bone marrow disorders), destruction by the immune system (immune thrombocytopenic purpura/ITP), or consumption (e.g., thrombotic thrombocytopenic purpura/TTP, hemolytic-uremic syndrome/HUS, paroxysmal nocturnal hemoglobinuria/PNH, disseminated intravascular coagulation/DIC, heparin-induced thrombocytopenia/HIT). Most consumptive conditions lead to platelet activation, and some are associated with thrombosis.

Coagulation factor disorders

The best-known coagulation factor disorders are the hemophilias. The three main forms are hemophilia A (factor VIII deficiency), hemophilia B (factor IX deficiency or "Christmas disease") and hemophilia C (factor XI deficiency, mild bleeding tendency). Hemophilia A and B are X-linked recessive disorders, whereas Hemophilia C is a much more rare autosomal recessive disorder most commonly seen in Ashkenazi Jews.

Von Willebrand disease (which behaves more like a platelet disorder except in severe cases), is the most common hereditary bleeding disorder and is characterized as being inherited autosomal recessive or dominant. In this disease, there is a defect in von Willebrand factor (vWF), which mediates the binding of glycoprotein Ib (GPIb) to collagen. This binding helps mediate the activation of platelets and formation of primary hemostasis.

Bernard–Soulier syndrome is a defect or deficiency in GPIb. GPIb, the receptor for vWF, can be defective and lead to lack of primary clot formation (primary hemostasis) and increased bleeding tendency. This is an autosomal recessive inherited disorder.

Thrombasthenia of Glanzmann and Naegeli (Glanzmann thrombasthenia) is extremely rare. It is characterized by a defect in GPIIb/IIIa fibrinogen receptor complex. When GPIIb/IIIa receptor is dysfunctional, fibrinogen cannot cross-link platelets, which inhibits primary hemostasis. This is an autosomal recessive inherited disorder.

In liver failure (acute and chronic forms), there is insufficient production of coagulation factors by the liver; this may increase bleeding risk. 

Deficiency of Vitamin K may also contribute to bleeding disorders because clotting factor maturation depends on Vitamin K. 

Thrombosis is the pathological development of blood clots. These clots may break free and become mobile, forming an embolus or grow to such a size that occludes the vessel in which it developed. An embolism is said to occur when the thrombus (blood clot) becomes a mobile embolus and migrates to another part of the body, interfering with blood circulation and hence impairing organ function downstream of the occlusion. This causes ischemia and often leads to ischemic necrosis of tissue. Most cases of venous thrombosis are due to acquired states (older age, surgery, cancer, immobility) or inherited thrombophilias (e.g., antiphospholipid syndrome, factor V Leiden, and various other genetic deficiencies or variants).

Mutations in factor XII have been associated with an asymptomatic prolongation in the clotting time and possibly a tendency toward thrombophlebitis. Other mutations have been linked with a rare form of hereditary angioedema (type III) essentialism.

Pharmacology

Procoagulants

The use of adsorbent chemicals, such as zeolites, and other hemostatic agents are also used for sealing severe injuries quickly (such as in traumatic bleeding secondary to gunshot wounds). Thrombin and fibrin glue are used surgically to treat bleeding and to thrombose aneurysms.

Desmopressin is used to improve platelet function by activating arginine vasopressin receptor 1A

Coagulation factor concentrates are used to treat hemophilia, to reverse the effects of anticoagulants, and to treat bleeding in patients with impaired coagulation factor synthesis or increased consumption. Prothrombin complex concentrate, cryoprecipitate and fresh frozen plasma are commonly used coagulation factor products. Recombinant activated human factor VII is increasingly popular in the treatment of major bleeding.

Tranexamic acid and aminocaproic acid inhibit fibrinolysis and lead to a de facto reduced bleeding rate. Before its withdrawal, aprotinin was used in some forms of major surgery to decrease bleeding risk and need for blood products.

Rivaroxaban drug bound to the coagulation factor Xa. The drug prevents this protein from activating the coagulation pathway by inhibiting its enzymatic activity.

Anticoagulants

Anticoagulants and anti-platelet agents are amongst the most commonly used medications. Anti-platelet agents include aspirin, dipyridamole, ticlopidine, clopidogrel, ticagrelor and prasugrel; the parenteral glycoprotein IIb/IIIa inhibitors are used during angioplasty. Of the anticoagulants, warfarin (and related coumarins) and heparin are the most commonly used. Warfarin affects the vitamin K-dependent clotting factors (II, VII, IX, X) and protein C and protein S, whereas heparin and related compounds increase the action of antithrombin on thrombin and factor Xa. A newer class of drugs, the direct thrombin inhibitors, is under development; some members are already in clinical use (such as lepirudin). Also in clinical use are other small molecular compounds that interfere directly with the enzymatic action of particular coagulation factors (the directly acting oral anticoagulants: dabigatran, rivaroxaban, apixaban, and edoxaban).

Operator (computer programming)

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