Pathogenic hypothesis on the possible role of CagA-positive strains in ischaemic heart disease. : Clinical effects of Helicobacter pylori outside the stomach : Nature Reviews Gastroenterology & Hepatology : Nature Publishing Group

Pathogenic hypothesis on the possible role of CagA-positive strains in ischaemic heart disease. : Clinical effects of Helicobacter pylori outside the stomach : Nature Reviews Gastroenterology & Hepatology : Nature Publishing Group

Figure 1: Pathogenic hypothesis on the possible role of CagA-positive strains in ischaemic heart disease.

FromClinical effects of Helicobacter pylori outside the stomach

• Francesco Franceschi,¹
• Giuseppe Zuccalà,¹
• Davide Roccarina¹
• & Antonio Gasbarrini²

Journal name:

Nature Reviews Gastroenterology & Hepatology

Year published:

(2013)

DOI:

doi:10.1038/nrgastro.2013.243

Molecular mimicry between anti-CagA antibodies and antigens localized inside the atherosclerotic plaque might contribute to the reactivation of the inflammatory response inside the lesion, possibly leading to destabilization and rupture.

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Additional data

Affiliations

1. Internal Medicine Institute, Catholic University of Rome, Policlinico A. Gemelli Largo A. Gemelli, 8-00168 Rome, Italy.

   • Francesco Franceschi,
   • Giuseppe Zuccalà &
   • Davide Roccarina

2. Internal Medicine and Gastroenterology, Catholic University of Rome, Policlinico A. Gemelli Largo A. Gemelli, 8-00168 Rome, Italy.

   • Antonio Gasbarrini

Contributions

D. Roccarina and G. Zuccalà researched the data for the article. F. Franceschi wrote the article. A. Gasbarrini reviewed and edited it. All authors discussed the content of the article before submission.

Competing interests statement

The authors declare no competing interests.

Corresponding author

Correspondence to:

• Francesco Franceschi

Author details

• Francesco Franceschi

  Francesco Franceschi, MD, PhD is Assistant Professor at the Institute of Internal Medicine of the Catholic University of Rome, Italy. He has worked as a Postdoctoral Research Fellow in Gastroenterology and Pathology at the Baylor College of Medicine, Houston, TX (USA). His main research interests in the field of gastroenterology are Helicobacter pylori infection, role of gut microbiota in health and diseases, probiotics and gastrointestinal cancers.
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• Giuseppe Zuccalà

  Giuseppe Zuccalà, MD, is Associate Professor at the Institute of Internal Medicine of the Catholic University of Rome, Italy. He has been a visiting Associate Professor and consultant epidemiologist at the Department of Geriatrics of the Wake Forest University, NC (USA). He serves as Chief of Emergency Medicine at Gemelli Hospital of Rome. His main research interests in the field of gastroenterology are epidemiology of gastrointestinal diseases and probiotics.

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• Davide Roccarina

  Davide Roccarina, MD, is a staff physician at the Catholic University of Rome, Italy. He is now in his second year of a PhD programme on physiopathology of metabolism and nutrition. His main research interests in the field of gastroenterology are Helicobacter pylori infection, probiotics and the role of abdominal ultrasonography in gastrointestinal diseases.

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• Antonio Gasbarrini

  Antonio Gasbarrini, MD, is Professor of Gastroenterology at the Catholic University of Rome, Italy. He has worked as Clinical and Research Fellow at the Department of Liver and Small Bowel Transplantation and Cell Physiology Institute of the University of Pittsburgh, PA (USA). He serves as Chief of Internal Medicine and Gastroenterology at Gemelli Hospital of Rome. His main research interests in the field of gastroenterology include Helicobacter pylori infection, role of gut microbiota in health and disease, probiotics, gastrointestinal cancer, IBD, coeliac disease and liver diseases.

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Nature Reviews Gastroenterology & Hepatology

ISSN: 1759-5045

EISSN: 1759-5053