5000 nanochannels control release; can deliver medicinal doses
for several days or a few weeks, also effective for HIV and damaged
joints
December 2, 2016
Original link: http://www.kurzweilai.net/implantable-device-targets-cancer-other-illnesses-with-controlled-long-term-drug-delivery
A drug-delivery capsule directly implanted into a cancerous tumor (credit: Lyle Hood/UTSA)
“The problem with most drug-delivery systems is that you have a specific minimum dosage of medicine that you need to take for it to be effective,” said Lyle Hood, assistant professor of mechanical engineering. “There’s also a limit to how much of the drug can be present in your system so that it doesn’t make you sick.” So a person who needs frequent doses of a specific medicine is required to take a pill every day or visit a doctor for injections.
KurzweilAI has covered a number of drug-delivery systems targeting cancer this year, based on “Nanoparticle cluster bombs,” “magnetically guided bacteria,” and “DNA-based lock-and-key pores,” for example.
What makes the UTSA system different is that it’s an implantable capsule, filled with medicinal fluid that uses about 5000 nanochannels to regulate the rate of release of the medicine, Hood explained. “This way, we have the proper amount of drugs in a person’s system to be effective, but not so much that they’ll harm that person.”
The capsule can deliver medicinal doses for several days or a few weeks, says Hood, and can be used for any kind of ailment that needs a localized delivery over several days or a few weeks. He believes this makes it especially tailored for treating cancer.
A larger version of the device, originally created by Alessandro Grattoni, chair of the Department of Nanomedicine at Houston Methodist Research Institute, can treat diseases like HIV for up to a year. “In HIV treatment, you can bombard the virus with drugs to the point that that person is no longer infectious and shows no symptoms,” Hood said. “The danger is that if that person stops taking their drugs, the amount of medicine in his or her system drops below the effective dose and the virus is able to become resistant to the treatments.”
The new capsule could provide a constant delivery of the HIV-battling drugs to prevent such an outcome. Hood noted it can also be used to deliver cortisone to damaged joints to avoid painful, frequent injections, and possibly even to pursue immunotherapy treatments for cancer patients.
“The idea behind immunotherapy is to deliver a cocktail of immune drugs to call attention to the cancer in a person’s body, so the immune system will be inspired to get rid of the cancer itself,” he added.
The current prototype of the device is permanent and injected under the skin, but the researchers are working on 3-D printing technology to make a new, fully biodegradable version of the device that could potentially be swallowed.
Abstract of Nanochannel Implants for Minimally-Invasive Insertion and Intratumoral Delivery
Novel approaches to achieve local, intratumoral drug delivery have the dual benefit of reducing systemic toxicity while enhancing efficacy for malignant cells. We have developed a new implantable system combining a next-generation BioNEMS nanofluidic membrane with parallel nanochannels that offers controlled release of biomolecules. Based on concentration-driven diffusive transport, nanochannel membranes provide a “drug agnostic” delivery mechanism. Integrating this nanotechnology within a small implantable capsule permits multipurpose functionality and compatibility with different therapeutic approaches as well as diagnostic imaging capability. A minimally-invasive, percutaneous trocar delivery mechanism enables serial implantation throughout a target tissue volume. In this manuscript, we demonstrate that this platform is capable of sustained delivery for chemotherapy, radiosensitization, immunomodulation, and imaging contrast, among others. This platform’s utility was established through release of doxorubicin, OX86, FGK45, and Magnevist. Further proof-of-concept experiments demonstrated successful in vivo implantation and intratumoral release of antibodies and contrast agents, as well as the platform’s MR-compatibility and capability as a radiopaque fiducial. These results provide strong evidence for a flexible, multifunctional nanofluidic implant capable of broadening local delivery utility in the clinic.
