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Scholarly approaches to mysticism include typologies of mysticism and the explanation of mystical states. Since the 19th century, mystical experience has evolved as a distinctive concept. It is closely related to "mysticism" but lays sole emphasis on the experiential aspect, be it spontaneous or induced by human behavior, whereas mysticism encompasses a broad range of practices aiming at a transformation of the person, not just inducing mystical experiences.

There is a longstanding discussion on the nature of socalled "introvertive mysticism." Perennialists regard this kind of mysticism to be universal. A popular variant of perennialism sees various mystical traditions as pointing to one universal transcendental reality, for which those experiences offer the proof. The perennial position is "largely dismissed by scholars" but "has lost none of its popularity". Instead, a constructionist approach became dominant during the 1970s, which states that mystical experiences are mediated by pre-existing frames of reference, while the attribution approach focuses on the (religious) meaning that is attributed to specific events.

Some neurological research has attempted to identify which areas in the brain are involved in so-called "mystical experience" and the temporal lobe is often claimed to play a significant role, likely attributable to claims made in Vilayanur Ramachandran's 1998 book, Phantoms in the Brain. However, these claims have not stood up to scrutiny.

In mystical and contemplative traditions, mystical experiences are not a goal in themselves, but part of a larger path of self-transformation.

Typologies of mysticism