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Postbiological evolution is a form of evolution which has transitioned from a biological paradigm, driven by the propagation of genes, to a nonbiological (e.g., cultural or technological) paradigm, presumably driven by some alternative replicator (e.g., memes or temes), and potentially resulting in the extinction, obsolescence, or trophic reorganization of the former. Researchers anticipating a postbiological universe tend to describe this transition as marked by the maturation and potential convergence of high technologies, such as artificial intelligence or nanotechnology.

Evolution from biological to mechanical