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Tuesday, March 25, 2025

Left-wing politics

From Wikipedia, the free encyclopedia
https://en.wikipedia.org/wiki/Left-wing_politics

Left-wing politics
describes the range of political ideologies that support and seek to achieve social equality and egalitarianism, often in opposition to social hierarchy as a whole or certain social hierarchies. Left-wing politics typically involve a concern for those in society whom its adherents perceive as disadvantaged relative to others as well as a belief that there are unjustified inequalities that need to be reduced or abolished, through radical means that change the nature of the society they are implemented in. According to emeritus professor of economics Barry Clark, supporters of left-wing politics "claim that human development flourishes when individuals engage in cooperative, mutually respectful relations that can thrive only when excessive differences in status, power, and wealth are eliminated."

Within the left–right political spectrum, Left and Right were coined during the French Revolution, referring to the seating arrangement in the French National Assembly. Those who sat on the left generally opposed the Ancien Régime and the Bourbon monarchy and supported the Revolution, the creation of a democratic republic and the secularisation of society while those on the right were supportive of the traditional institutions of the Ancien Régime. Usage of the term Left became more prominent after the restoration of the French monarchy in 1815, when it was applied to the Independents. The word wing was first appended to Left and Right in the late 19th century, usually with disparaging intent, and left-wing was applied to those who were unorthodox in their religious or political views.

Ideologies considered to be left-wing vary greatly depending on the placement along the political spectrum in a given time and place. At the end of the 18th century, upon the founding of the first liberal democracies, the term Left was used to describe liberalism in the United States and republicanism in France, supporting a lesser degree of hierarchical decision-making than the right-wing politics of the traditional conservatives and monarchists. In modern politics, the term Left typically applies to ideologies and movements to the left of classical liberalism, supporting some degree of democracy in the economic sphere. Today, ideologies such as social liberalism and social democracy are considered to be centre-left, while the Left is typically reserved for movements more critical of capitalism, including the labour movement, socialism, anarchism, communism, Marxism, and syndicalism, each of which rose to prominence in the 19th and 20th centuries. In addition, the term left-wing has also been applied to a broad range of culturally liberal social movements, including the civil rights movement, feminist movement, LGBT rights movement, abortion-rights movements, multiculturalism, anti-war movement, and environmental movement, as well as a wide range of political parties.

Positions

The following positions are typically associated with left-wing politics.

Economics

Left-leaning economic beliefs range from Keynesian economics and the welfare state through industrial democracy and the social market to the nationalization of the economy and central planning, to the anarcho-syndicalist advocacy of a council-based and self-managed anarchist communism. During the Industrial Revolution, leftists supported trade unions. At the beginning of the 20th century, many leftists advocated strong government intervention in the economy. Leftists continue to criticize the perceived exploitative nature of globalization, the "race to the bottom" and unjust lay-offs and exploitation of workers. In the last quarter of the 20th century, the belief that the government (ruling in accordance with the interests of the people) ought to be directly involved in the day-to-day workings of an economy declined in popularity amongst the centre-left, especially social democrats who adopted the Third Way. Left-wing politics are typically associated with popular or state control of major political and economic institutions.

Other leftists believe in Marxian economics, named after the economic theories of Karl Marx. Some distinguish Marx's economic theories from his political philosophy, arguing that Marx's approach to understanding the economy is independent of his advocacy of revolutionary socialism or his belief in the inevitability of a proletarian revolution. Marxian economics do not exclusively rely on Marx and draw from a range of Marxist and non-Marxist sources. The dictatorship of the proletariat and workers' state are terms used by some Marxists, particularly Leninists and Marxist–Leninists, to describe what they see as a temporary state between the capitalist state of affairs and a communist society. Marx defined the proletariat as salaried workers, in contrast to the lumpenproletariat, who he defined as the outcasts of society such as beggars, tricksters, entertainers, buskers, criminals and prostitutes. The political relevance of farmers has divided the left. In Das Kapital, Marx scarcely mentioned the subject. Mikhail Bakunin thought the lumpenproletariat was a revolutionary class, while Mao Zedong believed that it would be rural peasants, not urban workers, who would bring about the proletarian revolution.

Left-libertarians, anarchists and libertarian socialists believe in a decentralized economy run by trade unions, workers' councils, cooperatives, municipalities and communes, opposing both state and private control of the economy, preferring social ownership and local control in which a nation of decentralized regions is united in a confederation. The global justice movement, also known as the anti-globalisation movement and the alter-globalisation movement, protests against corporate economic globalisation due to its negative consequences for the poor, workers, the environment, and small businesses.

Leftists generally believe in innovation in various technological and philosophical fields and disciplines to help causes they support.

Environment

One of the foremost left-wing advocates was Thomas Paine, one of the first individuals since left and right became political terms to describe the collective human ownership of the world which he speaks of in Agrarian Justice. As such, most of left-wing thought and literature regarding environmentalism stems from this duty of ownership and the aforementioned form of cooperative ownership means that humanity must take care of the Earth. This principle is reflected in much of the historical left-wing thought and literature that came afterwards, although there were disagreements about what this entailed. Both Karl Marx and the early socialist philosopher and scholar William Morris arguably had a concern for environmental matters. According to Marx, "[e]ven an entire society, a nation, or all simultaneously existing societies taken together, are not the owners of the earth. They are simply its possessors, its beneficiaries, and have to bequeath it in an improved state to succeeding generations". Following the Russian Revolution, environmental scientists such as revolutionary Alexander Bogdanov and the Proletkult organisation made efforts to incorporate environmentalism into Bolshevism and "integrate production with natural laws and limits" in the first decade of Soviet rule, before Joseph Stalin attacked ecologists and the science of ecology, purged environmentalists and promoted the pseudoscience of Trofim Lysenko during his rule up until his death in 1953. Similarly, Mao Zedong rejected environmentalism and believed that based on the laws of historical materialism, all of nature must be put into the service of revolution.

From the 1970s onwards, environmentalism became an increasing concern of the left, with social movements and several unions campaigning on environmental issues and causes. In Australia, the left-wing Builders Labourers Federation, led by the communist Jack Mundy, united with environmentalists to place green bans on environmentally destructive development projects. Several segments of the socialist and Marxist left consciously merged environmentalism and anti-capitalism into an eco-socialist ideology. Barry Commoner articulated a left-wing response to The Limits to Growth model that predicted catastrophic resource depletion and spurred environmentalism, postulating that capitalist technologies were the key cause responsible for environmental degradation, as opposed to human population pressures. Environmental degradation can be seen as a class or equity issue, as environmental destruction disproportionately affects poorer communities and countries.

Global warming was the cover story of this 2007 issue of the Ms. magazine.

Several left-wing or socialist groupings have an overt environmental concern and several green parties contain a strong socialist presence. The Green Party of England and Wales features an eco-socialist group, the Green Left, which was founded in June 2005. Its members held several influential positions within the party, including both the former Principal Speakers Siân Berry and Derek Wall, himself an eco-socialist and Marxist academic. In Europe, several green left political parties such as the European United Left–Nordic Green Left combine traditional social-democratic values such as a desire for greater economic equality and workers rights with demands for environmental protection. Democratic socialist Bolivian president Evo Morales has traced environmental degradation to capitalist consumerism, stating that "[t]he Earth does not have enough for the North to live better and better, but it does have enough for all of us to live well". James Hansen, Noam Chomsky, Raj Patel, Naomi Klein, The Yes Men and Dennis Kucinich hold similar views.

In climate change mitigation, the Left is also divided over how to effectively and equitably reduce carbon emissions as the center-left often advocates a reliance on market measures such as emissions trading and a carbon tax while those further to the left support direct government regulation and intervention in the form of a Green New Deal, either alongside or instead of market mechanisms.

Nationalism, anti-imperialism and anti-nationalism

The question of nationality, imperialism and nationalism has been a central feature of political debates on the Left. During the French Revolution, nationalism was a key policy of the Republican Left. The Republican Left advocated for civic nationalism and argued that the nation is a "daily plebiscite" formed by the subjective "will to live together". Related to revanchism, the belligerent will to take revenge against Germany and retake control of Alsace-Lorraine, nationalism was sometimes opposed to imperialism. In the 1880s, there was a debate between leftists such as the Radical Georges Clemenceau, the Socialist Jean Jaurès and the nationalist Maurice Barrès, who argued that colonialism diverted France from liberating the "blue line of the Vosges", in reference to Alsace-Lorraine; and the "colonial lobby" such as Jules Ferry of the Moderate Republicans, Léon Gambetta of the Republicans and Eugène Etienne, the president of the Parliamentary Colonial Group. After the antisemitic Dreyfus Affair in which officer Alfred Dreyfus was falsely convicted of sedition and exiled to a penal colony in 1894 before being exonerated in 1906, nationalism in the form of Boulangism increasingly became associated with the far-right.

The Marxist social class theory of proletarian internationalism asserts that members of the working class should act in solidarity with working people in other countries in pursuit of a common class interest, rather than only focusing on their own countries. Proletarian internationalism is summed up in the slogan: "Workers of the world, unite!", the last line of The Communist Manifesto. Union members had learned that more members meant more bargaining power. Taken to an international level, leftists argued that workers should act in solidarity with the international proletariat in order to further increase the power of the working class. Proletarian internationalism saw itself as a deterrent against war and international conflicts, because people with a common interest are less likely to take up arms against one another, instead focusing on fighting the bourgeoisie as the ruling class. According to Marxist theory, the antonym of proletarian internationalism is bourgeois nationalism. Some Marxists, together with others on the left, view nationalism, racism (including antisemitism) and religion as divide and conquer tactics used by the ruling classes to prevent the working class from uniting against them in solidarity with one another. Left-wing movements have often taken up anti-imperialist positions. Anarchism has developed a critique of nationalism that focuses on nationalism's role in justifying and consolidating state power and domination. Through its unifying goal, nationalism strives for centralisation (both in specific territories and in a ruling elite of individuals) while it prepares a population for capitalist exploitation. Within anarchism, this subject has been extensively discussed by Rudolf Rocker in his book titled Nationalism and Culture and by the works of Fredy Perlman such as Against His-Story, Against Leviathan and The Continuing Appeal of Nationalism.

The failure of revolutions in Germany and Hungary in the 1918–1920 years ended Bolshevik hopes for an imminent world revolution and led to the promotion of the doctrine of socialism in one country by Joseph Stalin. In the first edition of his book titled Osnovy Leninizma (Foundations of Leninism, 1924), Stalin argued that revolution in one country is insufficient. By the end of that year in the second edition of the book, he argued that the "proletariat can and must build the socialist society in one country". In April 1925, Nikolai Bukharin elaborated on the issue in his brochure titled Can We Build Socialism in One Country in the Absence of the Victory of the West-European Proletariat?, whose position was adopted as state policy after Stalin's January 1926 article titled On the Issues of Leninism (К вопросам ленинизма) was published. This idea was opposed by Leon Trotsky and his supporters, who declared the need for an international "permanent revolution" and condemned Stalin for betraying the goals and ideals of the socialist revolution. Various Fourth Internationalist groups around the world who describe themselves as Trotskyist see themselves as standing in this tradition while Maoist China formally supported the theory of socialism in one country.

European social democrats strongly support Europeanism and supranational integration within the European Union, although there is a minority of nationalists and Eurosceptics on the left. Several scholars have linked this form of left-wing nationalism to the pressure generated by economic integration with other countries, often encouraged by neoliberal free trade agreements. This view is sometimes used to justify hostility towards supranational organizations. Left-wing nationalism can also refer to any form of nationalism which emphasizes a leftist working-class populist agenda that seeks to overcome exploitation or oppression by other nations. Many Third World anti-colonialist movements have adopted leftist and socialist ideas. Third-Worldism is a tendency within leftist thought that regards the division between First World and Second World developed countries and Third World developing countries as being of high political importance. This tendency supports decolonization and national liberation movements against imperialism by capitalists. Third-Worldism is closely connected with African socialism, Latin American socialism, Maoism, pan-Africanism and pan-Arabism. Several left-wing groups in the developing world such as the Zapatista Army of National Liberation in Mexico, the Abahlali baseMjondolo in South Africa and the Naxalites in India have argued that the First World and the Second World Left takes a racist and paternalistic attitude towards liberation movements in the Third World.

Religion

The original French Left was firmly anti-clerical, strongly opposing the influence of the Roman Catholic Church and supporting atheism and the separation of church and state, ushering in a policy known as laïcité. Karl Marx asserted that "religion is the sigh of the oppressed creature, the heart of a heartless world, and the soul of soulless conditions. It is the opium of the people". In Soviet Russia, the Bolsheviks under Vladimir Lenin originally embraced an ideological principle which professed that all religion would eventually atrophy and resolved to eradicate organized Christianity and other religious institutions. In 1918, 10 Russian Orthodox hierarchs were summarily executed by a firing squad, and children were deprived of any religious education outside of the home.

Today in the Western world, those on the Left generally support secularization and the separation of church and state. However, religious beliefs have also been associated with many left-wing movements such as the progressive movement, the Social Gospel movement, the civil rights movement, the anti-war movement, the anti-capital punishment movement and Liberation Theology. Early utopian socialist thinkers such as Robert Owen, Charles Fourier and the Comte de Saint-Simon based their theories of socialism upon Christian principles. Other common leftist concerns such as pacifism, social justice, racial equality, human rights and the rejection of capitalism and excessive wealth can be found in the Bible.

In the late 19th century, the Protestant Social Gospel movement arose in the United States which integrated progressive and socialist thought with Christianity through faith-based social activism. Other left-wing religious movements include Buddhist socialism, Jewish socialism and Islamic socialism. There have been alliances between the left and anti-war Muslims, such as the Respect Party and the Stop the War Coalition in Britain. In France, the left has been divided over moves to ban the hijab from schools, with some leftists supporting a ban based on the separation of church and state in accordance with the principle of laïcité and other leftists opposing the prohibition based on personal and religious freedom.

Social progressivism and counterculture

Social progressivism is another common feature of modern leftism, particularly in the United States, where social progressives played an important role in the abolition of slavery, the enshrinement of women's suffrage in the United States Constitution, and the protection of civil rights, LGBTQ rights, women's rights and multiculturalism. Progressives have both advocated for alcohol prohibition legislation and worked towards its repeal in the mid to late 1920s and early 1930s. Current positions associated with social progressivism in the Western world include strong opposition to the death penalty, torture, mass surveillance, and the war on drugs, and support for abortion rights, cognitive liberty, LGBTQ rights including legal recognition of same-sex marriage, same-sex adoption of children, the right to change one's legal gender, distribution of contraceptives, and public funding of embryonic stem-cell research. The desire for an expansion of social and civil liberties often overlaps that of the libertarian movement. Public education was a subject of great interest to groundbreaking social progressives such as Lester Frank Ward and John Dewey, who believed that a democratic society and system of government was practically impossible without a universal and comprehensive nationwide system of education.

Various counterculture and anti-war movements in the 1960s and 1970s were associated with the New Left. Unlike the earlier leftist focus on labour union activism and a proletarian revolution, the New Left instead adopted a broader definition of political activism commonly called social activism. The New Left in the United States is associated with the hippie movement, mass protest movements on school campuses and a broadening of focus from protesting class-based oppression to include issues such as gender, race and sexual orientation. The British New Left was an intellectually driven movement which attempted to correct the perceived errors of the Old Left. The New Left opposed prevailing authoritarian structures in society which it designated as "The Establishment" and became known as the "Anti-Establishment". The New Left did not seek to recruit industrial workers en masse, but instead concentrated on a social activist approach to organization, convinced that they could be the source for a better kind of social revolution. This view has been criticized by several Marxists, especially Trotskyists, who characterized this approach as "substitutionism" which they described as a misguided and non-Marxist belief that other groups in society could "substitute" for and "replace" the revolutionary agency of the working class.

Many early feminists and advocates of women's rights were considered a part of the Left by their contemporaries. Feminist pioneer Mary Wollstonecraft was influenced by Thomas Paine. Many notable leftists have been strong supporters of gender equality such as Marxist philosophers and activists Rosa Luxemburg, Clara Zetkin and Alexandra Kollontai, anarchist philosophers and activists such as Virginia Bolten, Emma Goldman and Lucía Sánchez Saornil and democratic socialist philosophers and activists such as Helen Keller and Annie Besant. However, Marxists such as Rosa Luxemburg, Clara Zetkin, and Alexandra Kollontai, who are supporters of radical social equality for women and have rejected and opposed liberal feminism because they considered it to be a capitalist bourgeois ideology. Marxists were responsible for organizing the first International Working Women's Day events.

The women's liberation movement is closely connected to the New Left and other new social movements which openly challenged the orthodoxies of the Old Left. Socialist feminism as exemplified by the Freedom Socialist Party and Radical Women and Marxist feminism, spearheaded by Selma James, saw themselves as a part of the Left that challenges male-dominated and sexist structures within the Left. The connection between left-wing ideologies and the struggle for LGBTQ rights also has an important history. Prominent socialists who were involved in early struggles for LGBTQ rights include Edward Carpenter, Oscar Wilde, Harry Hay, Bayard Rustin and Daniel Guérin, among others. The New Left is also strongly supportive of LGBTQ rights and liberation, having been instrumental in the founding of the LGBTQ rights movement in the aftermath of the Stonewall Riots of 1969. Contemporary leftist activists and socialist countries such as Cuba are actively supportive of LGBTQ+ people and are involved in the struggle for LGBTQ+ rights and equality.

History

The 5 May 1789 opening of the Estates General of 1789 in Versailles

In politics, the term Left derives from the French Revolution as the political groups opposed to the royal veto privilege (Montagnard and Jacobin deputies from the Third Estate) generally sat to the left of the presiding member's chair in parliament while the ones in favour of the royal veto privilege sat on its right. That habit began in the original French National Assembly. Throughout the 19th century, the main line dividing Left and Right was between supporters of the French republic and those of the monarchy's privileges. The June Days uprising during the Second Republic was an attempt by the Left to re-assert itself after the 1848 Revolution, but only a small portion of the population supported this.

In the mid-19th century, nationalism, socialism, democracy and anti-clericalism became key features of the French Left. After Napoleon III's 1851 coup and the subsequent establishment of the Second Empire, Marxism began to rival radical republicanism and utopian socialism as a force within left-wing politics. The influential Communist Manifesto by Karl Marx and Friedrich Engels, published amidst the wave of revolutions of 1848 across Europe, asserted that all of human history is defined by class struggle. They predicted that a proletarian revolution would eventually overthrow bourgeois capitalism and create a stateless, moneyless and classless communist society. It was in this period that the word wing was appended to both Left and Right.

The International Workingmen's Association (1864–1876), sometimes called the First International, brought together delegates from many different countries, with many different views about how to reach a classless and stateless society. Following a split between supporters of Marx and Mikhail Bakunin, anarchists formed the Saint-Imier International and later the International Workers' Association (IWA–AIT). The Second International (1888–1916) became divided over the issue of World War I. Those who opposed the war, among them Vladimir Lenin and Rosa Luxemburg, saw themselves as further to the left.

In the United States, leftists such as social liberals, progressives and trade unionists were influenced by the works of Thomas Paine, who introduced the concept of asset-based egalitarianism which theorises that social equality is possible by a redistribution of resources. After the Reconstruction era in the aftermath of the American Civil War, the phrase "the Left" was used to describe those who supported trade unions, the civil rights movement and the anti-war movement. More recently, left-wing and right-wing have often been used as synonyms for the Democratic and Republican parties, or as synonyms for liberalism and conservatism, respectively.

During the 20th century, war resulted in a dramatic intensification of the pace of social changes, and was a crucial catalyst for the growth of left-wing politics. Since the Right was populist, both in the Western and the Eastern Bloc, anything viewed as avant-garde art was called leftist across Europe, thus the identification of Picasso's Guernica as "leftist" in Europe and the condemnation of the Russian composer Shostakovich's opera (The Lady Macbeth of Mtsensk District) in Pravda as follows: "Here we have 'leftist' confusion instead of natural, human music".

Types

The spectrum of left-wing politics ranges from centre-left to far-left or ultra-left. The term centre-left describes a position within the political mainstream that accepts capitalism and a market economy. The terms far-left and ultra-left are used for positions that are more radical, more strongly rejecting capitalism and mainstream representative democracy, instead advocating for a socialist society based on economic democracy and direct democracy, representing economic, political and social democracy. The centre-left includes social democrats, social liberals, progressives and greens. Centre-left supporters accept market allocation of resources in a mixed economy with an empowered public sector and a thriving private sector. Centre-left policies tend to favour limited state intervention in matters pertaining to the public interest.

In several countries, the terms far-left and radical left have been associated with many varieties of anarchism, autonomism and communism. They have been used to describe groups that advocate anti-capitalism and eco-terrorism. In France, a distinction is made between the centre-left and the left represented by the Socialist Party and the French Communist Party and the far-left as represented by anarcho-communists, Maoists and Trotskyists. The United States Department of Homeland Security defines "left-wing extremism" as groups that "seek to bring about change through violent revolution, rather than through established political processes". Similar to far-right politics, extremist far-left politics have motivated political violence, radicalization, genocide, terrorism, sabotage and damage to property, the formation of militant organizations, political repression, conspiracism, xenophobia, and nationalism.

In China, the term Chinese New Left denotes those who oppose the economic reforms enacted by Deng Xiaoping in the 1980s and 1990s, favour instead the restoration of Maoist policies and the immediate transition to a socialist economy. In the Western world, the term New Left is used for social and cultural politics.

In the United Kingdom during the 1980s, the term hard left was applied to supporters of Tony Benn such as the Campaign Group and those involved in the London Labour Briefing newspaper as well as Trotskyist groups such as Militant and the Alliance for Workers' Liberty. In the same period, the term soft left was applied to supporters of the British Labour Party who were perceived to be more moderate and closer to the centre, accepting Keynesianism. Under the leadership of Tony Blair and Gordon Brown, the Labour Party adopted the Third Way and rebranded itself as New Labour in order to promote the notion that it was less left-wing than it had been in the past to accommodate the neoliberal trend arising since the 1970s with the displacement of Keynesianism and post-war social democracy. One of the first actions of Ed Miliband, the Labour Party leader who succeeded Blair and Brown, was the rejection of the New Labour label and a promise to abandon the Third Way and turn back to the left. However, Labour's voting record in the House of Commons from 2010 to 2015 indicated that the Labour Party under Miliband had maintained the same distance from the left as it did under Blair. ,In contrast, the election of Jeremy Corbyn as the Labour Party leader was viewed by scholars and political commentators as Labour turning back toward its more classical socialist roots, rejecting neoliberalism and the Third Way whilst supporting a democratic socialist society and an end to austerity measures.

Adult stem cell

From Wikipedia, the free encyclopedia
Adult stem cell
Transmission electron micrograph of an adult stem cell displaying typical ultrastructural characteristics.

Adult stem cells are undifferentiated cells, found throughout the body after development, that multiply by cell division to replenish dying cells and regenerate damaged tissues. Also known as somatic stem cells (from Greek σωματικóς, meaning of the body), they can be found in juvenile, adult animals, and humans, unlike embryonic stem cells.

Scientific interest in adult stem cells is centered around two main characteristics. The first of which is their ability to divide or self-renew indefinitely, and the second their ability to generate all the cell types of the organ from which they originate, potentially regenerating the entire organ from a few cells. Unlike embryonic stem cells, the use of human adult stem cells in research and therapy is not considered to be controversial, as they are derived from adult tissue samples rather than human embryos designated for scientific research. The main functions of adult stem cells are to replace cells that are at risk of possibly dying as a result of disease or injury and to maintain a state of homeostasis within the cell. There are three main methods to determine if the adult stem cell is capable of becoming a specialized cell. The adult stem cell can be labeled in vivo and tracked, it can be isolated and then transplanted back into the organism, and it can be isolated in vivo and manipulated with growth hormones. They have mainly been studied in humans and model organisms, such as mice, rats and planarians.

Stem cell division and differentiation: A – stem cells; B – progenitor cell; C – differentiated cell; 1 – symmetric stem cell division; 2 – asymmetric stem cell division; 3 – progenitor division; 4 – terminal differentiation

Structure

Defining properties

A stem cell possesses two properties:

  • Self-renewal is the ability to go through numerous cycles of cell division while still maintaining its undifferentiated state. Stem cells can replicate several times and can result in the formation of two stem cells, one stem cell more differentiated than the other, or two differentiated cells.
  • Multipotency or multidifferentiative potential is the ability to generate progeny of several distinct cell types, (for example glial cells and neurons) as opposed to unipotency, which is the term for cells that are restricted to producing a single cell type. However, some researchers do not consider multipotency to be essential and believe that unipotent self-renewing stem cells can exist. These properties can be illustrated with relative ease in vitro, using methods such as clonogenic assays, where the progeny of a single cell is characterized. However, it is known that in vitro cell culture conditions can alter the behavior of cells, proving that a particular subpopulation of cells possesses stem cell properties in vivo is challenging, and so considerable debate exists as to whether some proposed stem cell populations in the adult are indeed stem cells.

Properties

Cell division

To ensure self-renewal, stem cells undergo two types of cell division (see Stem cell division and differentiation diagram). Symmetric division gives rise to two identical daughter stem cells, whereas asymmetric division produces one stem cell and one progenitor cell with limited self-renewal potential. Progenitors can go through several rounds of cell division before finally differentiating into a mature cell. It is believed that the molecular distinction between symmetric and asymmetric divisions lies in the differential segregation of cell membrane proteins (such as receptors) and their associated proteins between the daughter cells.

Under normal conditions, tissue stem cells divide slowly and infrequently. They exhibit signs of quiescence or reversible growth arrest. The niche the stem cell is found in plays a large role in maintaining quiescence. Perturbed niches cause the stem cell to begin actively dividing again to replace lost or damaged cells until the niche is restored. In hematopoietic stem cells, the MAPK/ERK pathway and PI3K/AKT/mTOR pathway regulate this transition. The ability to regulate the cell cycle in response to external cues helps prevent stem cell exhaustion or the gradual loss of stem cells following an altered balance between dormant and active states. Infrequent cell divisions also help reduce the risk of acquiring DNA mutations that would be passed on to daughter cells.

Plasticity

Discoveries in recent years have suggested that adult stem cells might have the ability to differentiate into cell types from different germ layers. For instance, neural stem cells from the brain, which are derived from ectoderm, can differentiate into ectoderm, mesoderm, and endoderm. Stem cells from the bone marrow, which is derived from mesoderm, can differentiate into liver, lung, GI tract, and skin, which are derived from endoderm and mesoderm. This phenomenon is referred to as stem cell transdifferentiation or plasticity. It can be induced by modifying the growth medium when stem cells are cultured in vitro or by transplanting them to an organ of the body different from the one they were originally isolated from. There is yet no consensus among biologists on the prevalence and physiological and therapeutic relevance of stem cell plasticity. More recent findings suggest that pluripotent stem cells may reside in blood and adult tissues in a dormant state. These cells are referred to as "Blastomere Like Stem Cells" (BLSCs) and "very small embryonic-like" (VSEL) stem cells, and display pluripotency in vitro. As BLSCs and VSEL cells are present in virtually all adult tissues, including the lungs, brain, kidneys, muscles, and pancreas, co-purification of BLSCs and VSEL cells with other populations of adult stem cells may explain the apparent pluripotency of adult stem cell populations. However, recent studies have shown that both human and murine VSEL cells lack stem cell characteristics and are not pluripotent.

Aging

Stem cell function becomes impaired with age, and this contributes to progressive deterioration of tissue maintenance and repair. A likely important cause of increasing stem cell dysfunction is an age-dependent accumulation of DNA damage in both stem cells and the cells that comprise the stem cell environment. (See also DNA damage theory of aging.)

Adult stem cells can, however, be artificially reverted to a state where they behave like embryonic stem cells (including the associated DNA repair mechanisms). This was done with mice as early as 2006 with prospects to slow down human aging substantially. Such cells are one of the various classes of induced stem cells.

Function

Signaling pathways

Adult stem cell research has been focused on uncovering the general molecular mechanisms that control their self-renewal and differentiation.

The Notch pathway has been known to developmental biologists for decades. Its role in the control of stem cell proliferation has now been demonstrated for several cell types including hematopoietic, neural, and mammary stem cells.
These developmental pathways are also strongly implicated as stem cell regulators.
The TGFβ family of cytokines regulate the stemness of both normal and cancer stem cells.

Types

Hematopoietic stem cells

Hematopoietic stem cells (HSCs) are stem cells that can differentiate into all blood cells. This process is called hematopoiesis. Hematopoietic stem cells are found in the bone marrow and umbilical cord blood. The HSCs are generally dormant when found in adults due to their nature.

Mammary stem cells

Mammary stem cells provide the source of cells for the growth of the mammary gland during puberty and gestation and play an important role in the carcinogenesis of the breast. Mammary stem cells have been isolated from human and mouse tissue as well as from cell lines derived from the mammary gland. Single such cells can give rise to both the luminal and myoepithelial cell types of the gland and have been shown to have the ability to regenerate the entire organ in mice.

Intestinal stem cells

Intestinal stem cells divide continuously throughout life and use a complex genetic program to produce the cells lining the surface of the small and large intestines. Intestinal stem cells reside near the base of the stem cell niche, called the crypts of Lieberkuhn. Intestinal stem cells are probably the source of most cancers of the small intestine and colon.

Mesenchymal stem cells

Mesenchymal stem cells (MSCs) are of stromal origin and may differentiate into a variety of tissues. MSCs have been isolated from the placenta, adipose tissue, lung, bone marrow and blood, Wharton's jelly from the umbilical cord, and teeth (perivascular niche of dental pulp and periodontal ligament). MSCs are attractive for clinical therapy due to their ability to differentiate, provide trophic support, and modulate innate immune response. These cells differentiate into various cell types such as osteoblasts, chondroblasts, adipocytes, neuroectodermal cells, and hepatocytes. Bioactive mediators that favor local cell growth are also secreted by MSCs. Anti-inflammatory effects on the local microenvironment, which promote tissue healing, are also observed. The inflammatory response can be modulated by adipose-derived regenerative cells (ADRC) including mesenchymal stem cells and regulatory T-lymphocytes. The mesenchymal stem cells thus alter the outcome of the immune response by changing the cytokine secretion of dendritic and T-cell subsets. This results in a shift from a pro-inflammatory environment to an anti-inflammatory or tolerant cell environment.

Endothelial stem cells

Endothelial stem cells are one of the three types of multipotent stem cells found in the bone marrow. They are a rare and controversial group with the ability to differentiate into endothelial cells, the cells that line blood vessels as well as lymphatic vessels. Endothelial stem cells are an important aspect of the vascular network, even influencing the motion relating to white blood cells.

Neural stem cells

The existence of stem cells in the adult brain has been postulated following the discovery that the process of neurogenesis, the birth of new neurons, continues into adulthood in rats. The presence of stem cells in the mature primate brain was first reported in 1967. It has since been shown that new neurons are generated in adult mice, songbirds, and primates, including humans. Normally, adult neurogenesis is restricted to two areas of the brain – the subventricular zone, which lines the lateral ventricles, and the dentate gyrus of the hippocampal formation. Although the generation of new neurons in the hippocampus is well established, the presence of true self-renewing stem cells there has been debated. Under certain circumstances, such as following tissue damage in ischemia, neurogenesis can be induced in other brain regions, including the neocortex.

Neural stem cells are commonly cultured in vitro as so-called neurospheres – floating heterogeneous aggregates of cells, containing a large proportion of stem cells. They can be propagated for extended periods and differentiated into both neuronal and glial cells, and therefore behave as stem cells. However, some recent studies suggest that this behavior is induced by the culture conditions in progenitor cells, the progeny of stem cell division that normally undergo a strictly limited number of replication cycles in vivo. Furthermore, neurosphere-derived cells do not behave as stem cells when transplanted back into the brain.

Neural stem cells share many properties with hematopoietic stem cells (HSCs). Remarkably, when injected into the blood, neurosphere-derived cells differentiate into various cell types of the immune system.

Olfactory adult stem cells

Olfactory adult stem cells have been successfully harvested from the human olfactory mucosa cells, which are found in the lining of the nose and are involved in the sense of smell. If they are given the right chemical environment, these cells have the same ability as embryonic stem cells to develop into many different cell types. Olfactory stem cells hold the potential for therapeutic applications and, in contrast to neural stem cells, can be harvested with ease without harm to the patient. This means they can be easily obtained from all individuals, including older patients who might be most in need of stem cell therapies.

Neural crest stem cells

Hair follicles contain two types of stem cells, one of which appears to represent a remnant of the stem cells of the embryonic neural crest. Similar cells have been found in the gastrointestinal tract, sciatic nerve, cardiac outflow tract and spinal and sympathetic ganglia. These cells can generate neurons, Schwann cells, myofibroblasts, chondrocytes, and melanocytes.

Testicular cells

Multipotent stem cells with a claimed equivalency to embryonic stem cells have been derived from spermatogonial progenitor cells found in the testicles of laboratory mice by scientists in Germany and the United States, and, a year later, researchers from Germany and the United Kingdom confirmed the same capability using cells from the testicles of humans. The extracted stem cells are known as human adult germline stem cells (GSCs)

Multipotent stem cells have also been derived from germ cells found in human testicles.

Clinical significance

Adult stem cell treatments have been used for many years to successfully treat leukemia and related bone/blood cancers utilizing bone marrow transplants. The use of adult stem cells in research and therapy is not considered as controversial as the use of embryonic stem cells, because the production of adult stem cells does not require the destruction of an embryo.

Early regenerative applications of adult stem cells have focused on intravenous delivery of blood progenitors known as Hematopoietic Stem Cells (HSCs). CD34+ hematopoietic Stem Cells have been clinically applied to treat various diseases including spinal cord injury, liver cirrhosis and Peripheral Vascular disease. Research has shown that CD34+ hematopoietic Stem Cells are relatively more numerous in men than in women of reproductive age group among spinal cord Injury victims. Other early commercial applications have focused on Mesenchymal Stem Cells (MSCs). For both cell lines, direct injection or placement of cells into a site in need of repair may be the preferred method of treatment, as vascular delivery suffers from a "pulmonary first pass effect" where intravenously injected cells are sequestered in the lungs. Clinical case reports in orthopedic applications have been published. Wakitani has published a small case series of nine defects in five knees involving surgical transplantation of mesenchymal stem cells with coverage of the treated chondral defects. Centeno et al. have reported high-field MRI evidence of increased cartilage and meniscus volume in individual human clinical subjects as well as a large n=227 safety study. Many other stem cell-based treatments are operating outside the US, with much controversy being reported regarding these treatments as some feel more regulation is needed as clinics tend to exaggerate claims of success and minimize or omit risks.

Therapies

The therapeutic potential of adult stem cells is the focus of much scientific research, due to their ability to be harvested from the parent body that is females during the delivery. In common with embryonic stem cells, adult stem cells can differentiate into more than one cell type, but unlike the former they are often restricted to certain types or "lineages". The ability of a differentiated stem cell of one lineage to produce cells of a different lineage is called transdifferentiation. Some types of adult stem cells are more capable of transdifferentiation than others, but for many there is no evidence that such a transformation is possible. Consequently, adult stem therapies require a stem cell source of the specific lineage needed, and harvesting and/or culturing them up to the numbers required is a challenge. Additionally, cues from the immediate environment (including how stiff or porous the surrounding structure/extracellular matrix is) can alter or enhance the fate and differentiation of the stem cells.

Sources

Pluripotent stem cells, i.e. cells that can give rise to any fetal or adult cell type, can be found in several tissues, including umbilical cord blood. Using genetic reprogramming, pluripotent stem cells equivalent to embryonic stem cells have been derived from human adult skin tissue. Other adult stem cells are multipotent, meaning there are several limited types of cell they can become, and are generally referred to by their tissue origin (such as mesenchymal stem cell, adipose-derived stem cell, endothelial stem cell, etc.). A great deal of adult stem cell research has focused on investigating their capacity to divide or self-renew indefinitely, and their differentiation potential. In mice, pluripotent stem cells can be directly generated from adult fibroblast cultures.

Research

Cancer

In recent years, acceptance of the concept of adult stem cells has increased. There is now a hypothesis that stem cells reside in many adult tissues and that these unique reservoirs of cells not only are responsible for the normal reparative and regenerative processes but are also considered to be a prime target for genetic and epigenetic changes, culminating in many abnormal conditions including cancer. (See cancer stem cell for more details.)

Multidrug resistance

Adult stem cells express transporters of the ATP-binding cassette family that actively pump a diversity of organic molecules out of the cell. Many pharmaceuticals are exported by these transporters conferring multidrug resistance onto the cell. This complicates the design of drugs, for instance, neural stem cell-targeted therapies for the treatment of clinical depression.

Lung Organoid Model: Lung Disease in COVID-19

The virus that causes COVID-19, SARS-CoV-2, damages the lungs extensively in the presence of an overreactive immune response. Adult stem cells were extracted from deep lung biopsies and used to construct a complete lung model with both proximal and distal airway epithelia. After being developed in 3D cultures, the organoids were separated into individual cells to form 2D monolayers. These lung models were used to study the damage SARS-CoV-2 causes when applied to the apical side of the transwell.

Stroke Treatment

Due to their multipotency, capacity to release growth factors, and immunomodulatory abilities, stem cell-based therapies have become a viable tool for the treatment of both acute and delayed phases of stroke. By inducing neurogenesis, angiogenesis, and synaptogenesis as well as activating endogenous restorative processes through the generation of cytokines and trophic factors, this transdifferentiation can form cells with a neural lineage.

Measurement uncertainty

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