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Deuterium fusion, also called deuterium burning, is a nuclear fusion reaction that occurs in stars and some substellar objects, in which a deuterium nucleus and a proton combine to form a helium-3 nucleus. It occurs as the second stage of the proton–proton chain reaction, in which a deuterium nucleus formed from two protons fuses with another proton, but can also proceed from primordial deuterium.

In protostars