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Friday, September 16, 2022

Creation science

From Wikipedia, the free encyclopedia

Creation science or scientific creationism is a pseudoscientific form of Young Earth creationism which claims to offer scientific arguments for certain literalist and inerrantist interpretations of the Bible. It is often presented without overt faith-based language, but instead relies on reinterpreting scientific results to argue that various myths in the Book of Genesis and other select biblical passages are scientifically valid. The most commonly advanced ideas of creation science include special creation based on the Genesis creation narrative and flood geology based on the Genesis flood narrative. Creationists also claim they can disprove or reexplain a variety of scientific facts, theories and paradigms of geology, cosmology, biological evolution, archaeology, history, and linguistics using creation science. Creation science was foundational to intelligent design.

The overwhelming consensus of the scientific community is that creation science fails to qualify as scientific because it lacks empirical support, supplies no testable hypotheses, and resolves to describe natural history in terms of scientifically untestable supernatural causes. Courts, most often in the United States where the question has been asked in the context of teaching the subject in public schools, have consistently ruled since the 1980s that creation science is a religious view rather than a scientific one. Historians, philosophers of science and skeptics have described creation science as a pseudoscientific attempt to map the Bible into scientific facts. Professional biologists have criticized creation science for being unscholarly, and even as a dishonest and misguided sham, with extremely harmful educational consequences.

Beliefs and activities

Religious basis

Creation science is based largely upon chapters 1–11 of the Book of Genesis. These describe how God calls the world into existence through the power of speech ("And God said, Let there be light," etc.) in six days, calls all the animals and plants into existence, and molds the first man from clay and the first woman from a rib taken from the man's side; a worldwide flood destroys all life except for Noah and his family and representatives of the animals, and Noah becomes the ancestor of the 70 "nations" of the world; the nations live together until the incident of the Tower of Babel, when God disperses them and gives them their different languages. Creation science attempts to explain history and science within the span of Biblical chronology, which places the initial act of creation some six thousand years ago.

Modern religious affiliations

Most creation science proponents hold fundamentalist or Evangelical Christian beliefs in Biblical literalism or Biblical inerrancy, as opposed to the higher criticism supported by liberal Christianity in the Fundamentalist–Modernist Controversy. However, there are also examples of Islamic and Jewish scientific creationism that conform to the accounts of creation as recorded in their religious doctrines.

The Seventh-day Adventist Church has a history of support for creation science. This dates back to George McCready Price, an active Seventh-day Adventist who developed views of flood geology, which formed the basis of creation science. This work was continued by the Geoscience Research Institute, an official institute of the Seventh-day Adventist Church, located on its Loma Linda University campus in California.

Creation science is generally rejected by the Church of England as well as the Roman Catholic Church. The Pontifical Gregorian University has officially discussed intelligent design as a "cultural phenomenon" without scientific elements. The Church of England's official website cites Charles Darwin's local work assisting people in his religious parish.

Views on science

Creation science rejects evolution and the common descent of all living things on Earth. Instead, it asserts that the field of evolutionary biology is itself pseudoscientific or even a religion. Creationists argue instead for a system called baraminology, which considers the living world to be descended from uniquely created kinds or "baramins."

Creation science incorporates the concept of catastrophism to reconcile current landforms and fossil distributions with Biblical interpretations, proposing the remains resulted from successive cataclysmic events, such as a worldwide flood and subsequent ice age. It rejects one of the fundamental principles of modern geology (and of modern science generally), uniformitarianism, which applies the same physical and geological laws observed on the Earth today to interpret the Earth's geological history.

Sometimes creationists attack other scientific concepts, like the Big Bang cosmological model or methods of scientific dating based upon radioactive decay. Young Earth creationists also reject current estimates of the age of the universe and the age of the Earth, arguing for creationist cosmologies with timescales much shorter than those determined by modern physical cosmology and geological science, typically less than 10,000 years.

The scientific community has overwhelmingly rejected the ideas put forth in creation science as lying outside the boundaries of a legitimate science. The foundational premises underlying scientific creationism disqualify it as a science because the answers to all inquiry therein are preordained to conform to Bible doctrine, and because that inquiry is constructed upon theories which are not empirically testable in nature.

Scientists also deem creation science's attacks against biological evolution to be without scientific merit. The views of the scientific community were accepted in two significant court decisions in the 1980s, which found the field of creation science to be a religious mode of inquiry, not a scientific one.

History

Creation science began in the 1960s, as a fundamentalist Christian effort in the United States to prove Biblical inerrancy and nullify the scientific evidence for evolution. It has since developed a sizable religious following in the United States, with creation science ministries branching worldwide. The main ideas in creation science are: the belief in creation ex nihilo (Latin: out of nothing); the conviction that the Earth was created within the last 6,000–10,000 years; the belief that humans and other life on Earth were created as distinct fixed "baraminological" kinds; and "flood geology" or the idea that fossils found in geological strata were deposited during a cataclysmic flood which completely covered the entire Earth. As a result, creationists also challenge the geologic and astrophysical measurements of the age of the Earth and the universe along with their origins, which creationists believe are irreconcilable with the account in the Book of Genesis. Creation science proponents often refer to the theory of evolution as "Darwinism" or as "Darwinian evolution."

The creation science texts and curricula that first emerged in the 1960s focused upon concepts derived from a literal interpretation of the Bible and were overtly religious in nature, most notably proposing Noah's flood in the Biblical Genesis account as an explanation for the geological and fossil record. These works attracted little notice beyond the schools and congregations of conservative fundamental and Evangelical Christians until the 1970s, when its followers challenged the teaching of evolution in the public schools and other venues in the United States, bringing it to the attention of the public-at-large and the scientific community. Many school boards and lawmakers were persuaded to include the teaching of creation science alongside evolution in the science curriculum. Creation science texts and curricula used in churches and Christian schools were revised to eliminate their Biblical and theological references, and less explicitly sectarian versions of creation science education were introduced in public schools in Louisiana, Arkansas, and other regions in the United States.

The 1982 ruling in McLean v. Arkansas found that creation science fails to meet the essential characteristics of science and that its chief intent is to advance a particular religious view. The teaching of creation science in public schools in the United States effectively ended in 1987 following the United States Supreme Court decision in Edwards v. Aguillard. The court affirmed that a statute requiring the teaching of creation science alongside evolution when evolution is taught in Louisiana public schools was unconstitutional because its sole true purpose was to advance a particular religious belief.

In response to this ruling, drafts of the creation science school textbook Of Pandas and People were edited to change references of creation to intelligent design before its publication in 1989. The intelligent design movement promoted this version. Requiring intelligent design to be taught in public school science classes was found to be unconstitutional in the 2005 Kitzmiller v. Dover Area School District federal court case.

Before 1960s

The teaching of evolution was gradually introduced into more and more public high school textbooks in the United States after 1900, but in the aftermath of the First World War the growth of fundamentalist Christianity gave rise to a creationist opposition to such teaching. Legislation prohibiting the teaching of evolution was passed in certain regions, most notably Tennessee's Butler Act of 1925. The Soviet Union's successful launch of Sputnik 1 in 1957 sparked national concern that the science education in public schools was outdated. In 1958, the United States passed National Defense Education Act which introduced new education guidelines for science instruction. With federal grant funding, the Biological Sciences Curriculum Study (BSCS) drafted new standards for the public schools' science textbooks which included the teaching of evolution. Almost half the nation's high schools were using textbooks based on the guidelines of the BSCS soon after they were published in 1963. The Tennessee legislature did not repeal the Butler Act until 1967.

Creation science (dubbed "scientific creationism" at the time) emerged as an organized movement during the 1960s. It was strongly influenced by the earlier work of armchair geologist George McCready Price who wrote works such as Illogical Geology: The Weakest Point in the Evolution Theory (1906) and The New Geology (1923) to advance what he termed "new catastrophism" and dispute the current geological time frames and explanations of geologic history. Price was cited at the Scopes Trial of 1925, but his writings had no credence among geologists and other scientists. Price's "new catastrophism" was also disputed by most other creationists until its revival with the 1961 publication of The Genesis Flood by John C. Whitcomb and Henry M. Morris, a work which quickly became an important text on the issue to fundamentalist Christians and expanded the field of creation science beyond critiques of geology into biology and cosmology as well. Soon after its publication, a movement was underway to have the subject taught in United States' public schools.

Court determinations

The various state laws prohibiting teaching of evolution were overturned in 1968 when the United States Supreme Court ruled in Epperson v. Arkansas such laws violated the Establishment Clause of the First Amendment to the United States Constitution. This ruling inspired a new creationist movement to promote laws requiring that schools give balanced treatment to creation science when evolution is taught. The 1981 Arkansas Act 590 was one such law that carefully detailed the principles of creation science that were to receive equal time in public schools alongside evolutionary principles. The act defined creation science as follows:

"'Creation-science' means the scientific evidences for creation and inferences from those evidences. Creation-science includes the scientific evidences and related inferences that indicate:

  1. Sudden creation of the universe, and, in particular, life, from nothing;
  2. The insufficiency of mutation and natural selection in bringing about development of all living kinds from a single organism;
  3. Changes only with fixed limits of originally created kinds of plants and animals;
  4. Separate ancestry for man and apes;
  5. Explanation of the earth's geology by catastrophism, including the occurrence of worldwide flood; and
  6. A relatively recent inception of the earth and living kinds."

This legislation was examined in McLean v. Arkansas, and the ruling handed down on January 5, 1982, concluded that creation-science as defined in the act "is simply not science"McLean v. Arkansas Bd. of Ed., 529 (United States District Court for the Eastern District of Arkansas 1982).. The judgement defined the following as essential characteristics of scienceMcLean v. Arkansas Bd. of Ed., 529 (United States District Court for the Eastern District of Arkansas 1982).:

  1. It is guided by natural law;
  2. It has to be explanatory by reference to nature law;
  3. It is testable against the empirical world;
  4. Its conclusions are tentative, i.e., are not necessarily the final word; and
  5. It is falsifiable.

The court ruled that creation science failed to meet these essential characteristics and identified specific reasons. After examining the key concepts from creation science, the court found:

  1. Sudden creation "from nothing" calls upon a supernatural intervention, not natural law, and is neither testable nor falsifiable
  2. Objections in creation science that mutation and natural selection are insufficient to explain common origins was an incomplete negative generalization
  3. 'Kinds' are not scientific classifications, and creation science's claims of an outer limit to the evolutionary change possible of species are not explained scientifically or by natural law
  4. The separate ancestry of man and apes is an assertion rather than a scientific explanation, and did not derive from any scientific fact or theory
  5. Catastrophism, including its identification of the worldwide flood, failed as a science
  6. "Relatively recent inception" was the product of religious readings and had no scientific meaning, and was neither the product of, nor explainable by, natural law; nor is it tentative

The court further noted that no recognized scientific journal had published any article espousing the creation science theory as described in the Arkansas law, and stated that the testimony presented by defense attributing the absence to censorship was not credible.

In its ruling, the court wrote that for any theory to qualify as scientific, the theory must be tentative, and open to revision or abandonment as new facts come to light. It wrote that any methodology which begins with an immutable conclusion that cannot be revised or rejected, regardless of the evidence, is not a scientific theory. The court found that creation science does not culminate in conclusions formed from scientific inquiry, but instead begins with the conclusion, one taken from a literal wording of the Book of Genesis, and seeks only scientific evidence to support it.

The law in Arkansas adopted the same two-model approach as that put forward by the Institute for Creation Research, one allowing only two possible explanations for the origins of life and existence of man, plants and animals: it was either the work of a creator or it was not. Scientific evidence that failed to support the theory of evolution was posed as necessarily scientific evidence in support of creationism, but in its judgment the court ruled this approach to be no more than a "contrived dualism which has not scientific factual basis or legitimate educational purpose."

The judge concluded that "Act 590 is a religious crusade, coupled with a desire to conceal this fact," and that it violated the First Amendment's Establishment Clause. The decision was not appealed to a higher court, but had a powerful influence on subsequent rulings. Louisiana's 1982 Balanced Treatment for Creation-Science and Evolution-Science Act, authored by State Senator Bill P. Keith, judged in the 1987 United States Supreme Court case Edwards v. Aguillard, and was handed a similar ruling. It found the law to require the balanced teaching of creation science with evolution had a particular religious purpose and was therefore unconstitutional.

Intelligent design splits off

In 1984, The Mystery of Life's Origin was first published. It was co-authored by chemist and creationist Charles B. Thaxton with Walter L. Bradley and Roger L. Olsen, the foreword written by Dean H. Kenyon, and sponsored by the Christian-based Foundation for Thought and Ethics (FTE). The work presented scientific arguments against current theories of abiogenesis and offered a hypothesis of special creation instead. While the focus of creation science had until that time centered primarily on the criticism of the fossil evidence for evolution and validation of the creation myth of the Bible, this new work posed the question whether science reveals that even the simplest living systems were far too complex to have developed by natural, unguided processes.

Kenyon later co-wrote with creationist Percival Davis a book intended as a "scientific brief for creationism" to use as a supplement to public high school biology textbooks. Thaxton was enlisted as the book's editor, and the book received publishing support from the FTE. Prior to its release, the 1987 Supreme Court ruling in Edwards v. Aguillard barred the teaching of creation science and creationism in public school classrooms. The book, originally titled Biology and Creation but renamed Of Pandas and People, was released in 1989 and became the first published work to promote the anti-evolutionist design argument under the name intelligent design. The contents of the book later became a focus of evidence in the federal court case, Kitzmiller v. Dover Area School District, when a group of parents filed suit to halt the teaching of intelligent design in Dover, Pennsylvania, public schools. School board officials there had attempted to include Of Pandas and People in their biology classrooms and testimony given during the trial revealed the book was originally written as a creationist text but following the adverse decision in the Supreme Court it underwent simple cosmetic editing to remove the explicit allusions to "creation" or "creator," and replace them instead with references to "design" or "designer."

By the mid-1990s, intelligent design had become a separate movement. The creation science movement is distinguished from the intelligent design movement, or neo-creationism, because most advocates of creation science accept scripture as a literal and inerrant historical account, and their primary goal is to corroborate the scriptural account through the use of science. In contrast, as a matter of principle, neo-creationism eschews references to scripture altogether in its polemics and stated goals (see Wedge strategy). By so doing, intelligent design proponents have attempted to succeed where creation science has failed in securing a place in public school science curricula. Carefully avoiding any reference to the identity of the intelligent designer as God in their public arguments, intelligent design proponents sought to reintroduce the creationist ideas into science classrooms while sidestepping the First Amendment's prohibition against religious infringement. However, the intelligent design curriculum was struck down as a violation of the Establishment Clause in Kitzmiller v. Dover Area School District, the judge in the case ruled "that ID is nothing less than the progeny of creationism."

Today, creation science as an organized movement is primarily centered within the United States. Creation science organizations are also known in other countries, most notably Creation Ministries International which was founded (under the name Creation Science Foundation) in Australia. Proponents are usually aligned with a Christian denomination, primarily with those characterized as evangelical, conservative, or fundamentalist. While creationist movements also exist in Islam and Judaism, these movements do not use the phrase creation science to describe their beliefs.

Issues

Creation science has its roots in the work of young Earth creationist George McCready Price disputing modern science's account of natural history, focusing particularly on geology and its concept of uniformitarianism, and his efforts instead to furnish an alternative empirical explanation of observable phenomena which was compatible with strict Biblical literalism. Price's work was later discovered by civil engineer Henry M. Morris, who is now considered to be the father of creation science. Morris and later creationists expanded the scope with attacks against the broad spectrum scientific findings that point to the antiquity of the Universe and common ancestry among species, including growing body of evidence from the fossil record, absolute dating techniques, and cosmogony.

The proponents of creation science often say that they are concerned with religious and moral questions as well as natural observations and predictive hypotheses. Many state that their opposition to scientific evolution is primarily based on religion.

The overwhelming majority of scientists are in agreement that the claims of science are necessarily limited to those that develop from natural observations and experiments which can be replicated and substantiated by other scientists, and that claims made by creation science do not meet those criteria. Duane Gish, a prominent creation science proponent, has similarly claimed, "We do not know how the creator created, what processes He used, for He used processes which are not now operating anywhere in the natural universe. This is why we refer to creation as special creation. We cannot discover by scientific investigation anything about the creative processes used by the Creator." But he also makes the same claim against science's evolutionary theory, maintaining that on the subject of origins, scientific evolution is a religious theory which cannot be validated by science.

Metaphysical assumptions

Creation science makes the a priori metaphysical assumption that there exists a creator of the life whose origin is being examined. Christian creation science holds that the description of creation is given in the Bible, that the Bible is inerrant in this description (and elsewhere), and therefore empirical scientific evidence must correspond with that description. Creationists also view the preclusion of all supernatural explanations within the sciences as a doctrinaire commitment to exclude the supreme being and miracles. They claim this to be the motivating factor in science's acceptance of Darwinism, a term used in creation science to refer to evolutionary biology which is also often used as a disparagement. Critics argue that creation science is religious rather than scientific because it stems from faith in a religious text rather than by the application of the scientific method. The United States National Academy of Sciences (NAS) has stated unequivocally, "Evolution pervades all biological phenomena. To ignore that it occurred or to classify it as a form of dogma is to deprive the student of the most fundamental organizational concept in the biological sciences. No other biological concept has been more extensively tested and more thoroughly corroborated than the evolutionary history of organisms." Anthropologist Eugenie Scott has noted further, "Religious opposition to evolution propels antievolutionism. Although antievolutionists pay lip service to supposed scientific problems with evolution, what motivates them to battle its teaching is apprehension over the implications of evolution for religion."

Creation science advocates argue that scientific theories of the origins of the Universe, Earth, and life are rooted in a priori presumptions of methodological naturalism and uniformitarianism, each of which they reject. In some areas of science such as chemistry, meteorology or medicine, creation science proponents do not necessarily challenge the application of naturalistic or uniformitarian assumptions, but instead single out those scientific theories they judge to be in conflict with their religious beliefs, and it is against those theories that they concentrate their efforts.

Religious criticism

Many mainstream Christian churches criticize creation science on theological grounds, asserting either that religious faith alone should be a sufficient basis for belief in the truth of creation, or that efforts to prove the Genesis account of creation on scientific grounds are inherently futile because reason is subordinate to faith and cannot thus be used to prove it.

Many Christian theologies, including Liberal Christianity, consider the Genesis creation narrative to be a poetic and allegorical work rather than a literal history, and many Christian churches—including the Eastern Orthodox Church, the Roman Catholic, Anglican and the more liberal denominations of the Lutheran, Methodist, Congregationalist and Presbyterian faiths—have either rejected creation science outright or are ambivalent to it. Belief in non-literal interpretations of Genesis is often cited as going back to Saint Augustine.

Theistic evolution and evolutionary creationism are theologies that reconcile belief in a creator with biological evolution. Each holds the view that there is a creator but that this creator has employed the natural force of evolution to unfold a divine plan. Religious representatives from faiths compatible with theistic evolution and evolutionary creationism have challenged the growing perception that belief in a creator is inconsistent with the acceptance of evolutionary theory. Spokespersons from the Catholic Church have specifically criticized biblical creationism for relying upon literal interpretations of biblical scripture as the basis for determining scientific fact.

Scientific criticism

Creation science
ClaimsThe Bible contains an accurate literal account of the origin of the Universe, Earth, life and humanity.
Related scientific disciplinesAnthropology, biology, geology, astronomy
Year proposed1923
Original proponentsGeorge McCready Price, Henry M. Morris, and John C. Whitcomb
Subsequent proponentsInstitute for Creation Research, Answers in Genesis
Pseudoscientific concepts

The National Academy of Sciences states that "the claims of creation science lack empirical support and cannot be meaningfully tested" and that "creation science is in fact not science and should not be presented as such in science classes." According to Joyce Arthur writing for Skeptic magazine, the "creation 'science' movement gains much of its strength through the use of distortion and scientifically unethical tactics" and "seriously misrepresents the theory of evolution."

Scientists have considered the hypotheses proposed by creation science and have rejected them because of a lack of evidence. Furthermore, the claims of creation science do not refer to natural causes and cannot be subject to meaningful tests, so they do not qualify as scientific hypotheses. In 1987, the United States Supreme Court ruled that creationism is religion, not science, and cannot be advocated in public school classrooms. Most mainline Christian denominations have concluded that the concept of evolution is not at odds with their descriptions of creation and human origins.

A summary of the objections to creation science by scientists follows:

  • Creation science is not falsifiable: An idea or hypothesis is generally not considered to be in the realm of science unless it can be potentially disproved with certain experiments, this is the concept of falsifiability in science. The act of creation as defined in creation science is not falsifiable because no testable bounds can be imposed on the creator. In creation science, the creator is defined as limitless, with the capacity to create (or not), through fiat alone, infinite universes, not just one, and endow each one with its own unique, unimaginable and incomparable character. It is impossible to disprove a claim when that claim as defined encompasses every conceivable contingency.
  • Creation science violates the principle of parsimony: Parsimony favours those explanations which rely on the fewest assumptions. Scientists prefer explanations that are consistent with known and supported facts and evidence and require the fewest assumptions to fill the remaining gaps. Many of the alternative claims made in creation science retreat from simpler scientific explanations and introduce more complications and conjecture into the equation.
  • Creation science is not, and cannot be, empirically or experimentally tested: Creationism posits supernatural causes which lie outside the realm of methodological naturalism and scientific experiment. Science can only test empirical, natural claims.
  • Creation science is not correctable, dynamic, tentative or progressive: Creation science adheres to a fixed and unchanging premise or "absolute truth," the "word of God," which is not open to change. Any evidence that runs contrary to that truth must be disregarded. In science, all claims are tentative, they are forever open to challenge, and must be discarded or adjusted when the weight of evidence demands it.

By invoking claims of "abrupt appearance" of species as a miraculous act, creation science is unsuited for the tools and methods demanded by science, and it cannot be considered scientific in the way that the term "science" is currently defined. Scientists and science writers commonly characterize creation science as a pseudoscience.

Historical, philosophical, and sociological criticism

Historically, the debate of whether creationism is compatible with science can be traced back to 1874, the year science historian John William Draper published his History of the Conflict between Religion and Science. In it Draper portrayed the entire history of scientific development as a war against religion. This presentation of history was propagated further by followers such as Andrew Dickson White in his two-volume A History of the Warfare of Science with Theology in Christendom (1896). Their conclusions have been disputed.

In the United States, the principal focus of creation science advocates is on the government-supported public school systems, which are prohibited by the Establishment Clause from promoting specific religions. Historical communities have argued that Biblical translations contain many translation errors and errata, and therefore that the use of biblical literalism in creation science is self-contradictory.

Kinds of creation science

Biology

Creationist arguments in relation to biology center on an idea derived from Genesis that states that life was created by God, in a finite number of "created kinds," rather than through biological evolution from a common ancestor. Creationists contend that any observable speciation descends from these distinctly created kinds through inbreeding, deleterious mutations and other genetic mechanisms. Whereas evolutionary biologists and creationists share similar views of microevolution, creationists reject the fact that the process of macroevolution can explain common ancestry among organisms far beyond the level of common species. Creationists contend that there is no empirical evidence for new plant or animal species, and deny fossil evidence has ever been found documenting the process.

Popular arguments against evolution have changed since the publishing of Henry M. Morris' first book on the subject, Scientific Creationism (1974), but some consistent themes remain: that missing links or gaps in the fossil record are proof against evolution; that the increased complexity of organisms over time through evolution is not possible due to the law of increasing entropy; that it is impossible that the mechanism of natural selection could account for common ancestry; and that evolutionary theory is untestable. The origin of the human species is particularly hotly contested; the fossil remains of hominid ancestors are not considered by advocates of creation biology to be evidence for a speciation event involving Homo sapiens. Creationists also assert that early hominids, are either apes, or humans.

Richard Dawkins has explained evolution as "a theory of gradual, incremental change over millions of years, which starts with something very simple and works up along slow, gradual gradients to greater complexity," and described the existing fossil record as entirely consistent with that process. Biologists emphasize that transitional gaps between recovered fossils are to be expected, that the existence of any such gaps cannot be invoked to disprove evolution, and that instead the fossil evidence that could be used to disprove the theory would be those fossils which are found and which are entirely inconsistent with what can be predicted or anticipated by the evolutionary model. One example given by Dawkins was, "If there were a single hippo or rabbit in the Precambrian, that would completely blow evolution out of the water. None have ever been found."

Geology

Flood geology

Flood geology is a concept based on the belief that most of Earth's geological record was formed by the Great Flood described in the story of Noah's Ark. Fossils and fossil fuels are believed to have formed from animal and plant matter which was buried rapidly during this flood, while submarine canyons are explained as having formed during a rapid runoff from the continents at the end of the flood. Sedimentary strata are also claimed to have been predominantly laid down during or after Noah's flood and orogeny. Flood geology is a variant of catastrophism and is contrasted with geological science in that it rejects standard geological principles such as uniformitarianism and radiometric dating. For example, the Creation Research Society argues that "uniformitarianism is wishful thinking."

Geologists conclude that no evidence for such a flood is observed in the preserved rock layers and moreover that such a flood is physically impossible, given the current layout of land masses. For instance, since Mount Everest currently is approximately 8.8 kilometres in elevation and the Earth's surface area is 510,065,600 km2, the volume of water required to cover Mount Everest to a depth of 15 cubits (6.8 m), as indicated by Genesis 7:20, would be 4.6 billion cubic kilometres. Measurements of the amount of precipitable water vapor in the atmosphere have yielded results indicating that condensing all water vapor in a column of atmosphere would produce liquid water with a depth ranging between zero and approximately 70mm, depending on the date and the location of the column. Nevertheless, there continue to be adherents to the belief in flood geology, and in recent years new creationist models have been introduced such as catastrophic plate tectonics and catastrophic orogeny.

Radiometric dating

Creationists point to experiments they have performed, which they claim demonstrate that 1.5 billion years of nuclear decay took place over a short period of time, from which they infer that "billion-fold speed-ups of nuclear decay" have occurred, a massive violation of the principle that radioisotope decay rates are constant, a core principle underlying nuclear physics generally, and radiometric dating in particular.

The scientific community points to numerous flaws in the creationists' experiments, to the fact that their results have not been accepted for publication by any peer-reviewed scientific journal, and to the fact that the creationist scientists conducting them were untrained in experimental geochronology. They have also been criticised for widely publicising the results of their research as successful despite their own admission of insurmountable problems with their hypothesis.

The constancy of the decay rates of isotopes is well supported in science. Evidence for this constancy includes the correspondences of date estimates taken from different radioactive isotopes as well as correspondences with non-radiometric dating techniques such as dendrochronology, ice core dating, and historical records. Although scientists have noted slight increases in the decay rate for isotopes subject to extreme pressures, those differences were too small to significantly impact date estimates. The constancy of the decay rates is also governed by first principles in quantum mechanics, wherein any deviation in the rate would require a change in the fundamental constants. According to these principles, a change in the fundamental constants could not influence different elements uniformly, and a comparison between each of the elements' resulting unique chronological timescales would then give inconsistent time estimates.

In refutation of young Earth claims of inconstant decay rates affecting the reliability of radiometric dating, Roger C. Wiens, a physicist specializing in isotope dating states:

There are only three quite technical instances where a half-life changes, and these do not affect the dating methods:

  1. "Only one technical exception occurs under terrestrial conditions, and this is not for an isotope used for dating. ... The artificially-produced isotope, beryllium-7 has been shown to change by up to 1.5%, depending on its chemical environment. ... Heavier atoms are even less subject to these minute changes, so the dates of rocks made by electron-capture decays would only be off by at most a few hundredths of a percent."
  2. "... Another case is material inside of stars, which is in a plasma state where electrons are not bound to atoms. In the extremely hot stellar environment, a completely different kind of decay can occur. 'Bound-state beta decay' occurs when the nucleus emits an electron into a bound electronic state close to the nucleus. ... All normal matter, such as everything on Earth, the Moon, meteorites, etc. has electrons in normal positions, so these instances never apply to rocks, or anything colder than several hundred thousand degrees."
  3. "The last case also involves very fast-moving matter. It has been demonstrated by atomic clocks in very fast spacecraft. These atomic clocks slow down very slightly (only a second or so per year) as predicted by Einstein's theory of relativity. No rocks in our solar system are going fast enough to make a noticeable change in their dates."

Radiohaloes

In the 1970s, young Earth creationist Robert V. Gentry proposed that radiohaloes in certain granites represented evidence for the Earth being created instantaneously rather than gradually. This idea has been criticized by physicists and geologists on many grounds including that the rocks Gentry studied were not primordial and that the radionuclides in question need not have been in the rocks initially.

Thomas A. Baillieul, a geologist and retired senior environmental scientist with the United States Department of Energy, disputed Gentry's claims in an article entitled, "'Polonium Haloes' Refuted: A Review of 'Radioactive Halos in a Radio-Chronological and Cosmological Perspective' by Robert V. Gentry." Baillieul noted that Gentry was a physicist with no background in geology and given the absence of this background, Gentry had misrepresented the geological context from which the specimens were collected. Additionally, he noted that Gentry relied on research from the beginning of the 20th century, long before radioisotopes were thoroughly understood; that his assumption that a polonium isotope caused the rings was speculative; and that Gentry falsely argued that the half-life of radioactive elements varies with time. Gentry claimed that Baillieul could not publish his criticisms in a reputable scientific journal, although some of Baillieul's criticisms rested on work previously published in reputable scientific journals.

Astronomy and cosmology

Creationist cosmologies

Several attempts have been made by creationists to construct a cosmology consistent with a young Universe rather than the standard cosmological age of the universe, based on the belief that Genesis describes the creation of the Universe as well as the Earth. The primary challenge for young-universe cosmologies is that the accepted distances in the Universe require millions or billions of years for light to travel to Earth (the "starlight problem"). An older creationist idea, proposed by creationist astronomer Barry Setterfield, is that the speed of light has decayed in the history of the Universe. More recently, creationist physicist Russell Humphreys has proposed a hypothesis called "white hole cosmology", asserting that the Universe expanded out of a white hole less than 10,000 years ago; claiming that the age of the universe is illusory and results from relativistic effects. Humphreys' cosmology is advocated by creationist organisations such as Answers in Genesis; however because its predictions conflict with current observations, it is not accepted by the scientific community.

Planetology

Various claims are made by creationists concerning alleged evidence that the age of the Solar System is of the order of thousands of years, in contrast to the scientifically accepted age of 4.6 billion years. It is commonly argued that the number of comets in the Solar System is much higher than would be expected given its supposed age. Young Earth Creationists reject the existence of the Kuiper belt and Oort cloud. They also argue that the recession of the Moon from the Earth is incompatible with either the Moon or the Earth being billions of years old. These claims have been refuted by planetologists.

In response to increasing evidence suggesting that Mars once possessed a wetter climate, some creationists have proposed that the global flood affected not only the Earth but also Mars and other planets. People who support this claim include creationist astronomer Wayne Spencer and Russell Humphreys.

An ongoing problem for creationists is the presence of impact craters on nearly all Solar System objects, which is consistent with scientific explanations of solar system origins but creates insuperable problems for young Earth claims. Creationists Harold Slusher and Richard Mandock, along with Glenn Morton (who later repudiated this claim) asserted that impact craters on the Moon are subject to rock flow, and so cannot be more than a few thousand years old. While some creationist astronomers assert that different phases of meteoritic bombardment of the Solar System occurred during "creation week" and during the subsequent Great Flood, others regard this as unsupported by the evidence and call for further research.

Polyculture

From Wikipedia, the free encyclopedia
 
Polyculture providing useful within-field diversity: companion planting of carrots and onions. The onion smell puts off carrot root fly, while the smell of carrots puts off onion fly.

In agriculture, polyculture is the practice of growing more than one crop species in the same space, at the same time. In doing this, polyculture attempts to mimic the diversity of natural ecosystems. Polyculture is the opposite of monoculture, in which only one plant or animal species are cultivated together. Polyculture can improve control of some pests, weeds, and diseases while reducing the need for pesticides. Intercrops of legumes with non-legumes can increase yields on low-nitrogen soils due to biological nitrogen fixation. However, polycultures can also reduce crop yields due to competition between the mixed species for light, water, or nutrients. It also complicates management as species have different growth rates, days to maturity, and harvest requirements. Monocultures are more amenable to mechanization. For these reasons, many farmers in large-scale agriculture continue to rely on monocultures and use crop rotation to add diversity to the system.

Other forms of polyculture can be found in permaculture and integrated aquaculture.

Historical and modern uses

Diversity of crops in space and time; monocultures and polycultures, and rotations of both.

Diversity in time
Low Higher
Cyclic Dynamic (non-cyclic)
Diversity in space Low Monoculture, one species in a field Continuous

monoculture,

monocropping

Crop rotation

(rotation of monocultures)

Sequence of monocultures
Higher Polyculture, two or more species

intermingled in a field

Continuous

polyculture

Rotation of polycultures Sequence of polycultures

Polyculture has traditionally been the most prevalent form of agriculture. A well-known example of historic polyculture is the intercropping of maize, beans, and squash plants in a group often referred to as "the three sisters". In this combination, the maize provides a structure for the bean to grow on, the bean provides nitrogen for all of the plants, while the squash suppresses weeds on the ground. This crop mixture can be traced back several thousand years ago to civilizations in Latin America and Africa and is representative of how species in polycultures sustain each other and minimize the need for human intervention. Integrated aquaculture, or the growing of seafood and plants together, has been common in parts of Eastern Asia for several thousand years as well. In China and Japan, for example, fish and shrimp have historically been grown in ponds with rice and seaweed. Other countries where polyculture has traditionally been a substantial part of agricultural and continues to be so today include those in the Himalayan region, Eastern Asia, South America, and Africa.

Because of the development of pesticides, herbicides, and fertilizers, monoculture became the predominant form of agriculture in the 1950s. The prevalence of polyculture declined greatly in popularity at that time in more economically developed countries where it was deemed to produce less yield while requiring more labor. Polyculture farming has not disappeared entirely though as traditional polyculture systems continue to be an essential part of the food production system today. Around 15% to 20% of the world's agriculture is estimated as relying on traditional polyculture systems. The majority of Latin American farmers continue to intercrop their maize, beans, and squash. Due to climate change, polyculture is returning in popularity in more developed countries as well as food producers seek to reduce their environmental and health impacts.

Common practices

The kinds of plants that are grown, their spatial distribution, and the time that they spend growing together determines the specific type of polyculture that is implemented. There is no limit for the types of plants or animals that can be grown together to form a polyculture. The time overlaps between plants can be asymmetrical as well, with one plant depending on the other for longer than is reciprocated, often due to differences in life spans.

Annual polycultures

Intercropping

When more than two crops are grown in complete spatial and temporal overlap with each other, it is referred to as intercropping. Intercropping is particularly useful in plots with limited land availability. Legumes are one of the most commonly intercropped crops, specifically legume-cereal mixtures. Legumes fix atmospheric nitrogen into the soil so that it is available for consumption by other plants in a process known as nitrogen fixation. The presence of legumes consequently eliminates the need for man-made nitrogen fertilizers in intercrops.

Cover cropping

When a crop is grown alongside another plant that is not a crop, the combination is a form of cover cropping. If the non-crop plant is a weed, the combination is called a weedy culture. Grasses and legumes are the most common cover crops. Cover crops are greatly beneficial as they can help prevent soil erosion, physically suppress weeds, improve surface water retention, and, in the case of legumes, provide nitrogen compounds as well. Single-species cover cropping, in rotation with cash crops, increases agroecosystem diversity; a cover crop polyculture further increases that diversity, and there is evidence, using a range of cover crop treatments with or without legumes, that this increases ecosystem functionality, in terms of weed suppression, nitrogen retention, and above-ground biomass.

Strip cropping

Strip cropping is a form of polyculture that involves growing different plants in alternating rows. While strip cropping does not involve the complete intermixing of plant species, it still provides many of the same benefits such as preventing soil erosion and aiding with nutrient cycling.

Permaculture

A coffee farm in Colombia where coffee plants are grown under several tree species in imitation of natural ecosystems. Trees provide valuable resources for the coffee plants such as shade, nutrients, and soil structure.

Permacultures include polycultures of perennial plants such as legume-grass mixtures and wildflower mixtures, popular in Europe and more temperate climates. These increase soil fertility through nitrogen fixation, decrease soil erosion, regulate water consumption, and decrease the need for tillage thereby conserving soil nutrients. Permacultures require even less human intervention than other forms of polyculture because of lower harvest and tillage rates.

In many Latin American countries, agroforestry is a popular form of permaculture as well where trees and crops are grown together. Trees provide shade for the crops alongside organic matter and nutrients when they shed their leaves or fruits. The elaborate root systems of trees also help prevent soil erosion and increase the presence of microbes in the soil. In addition to benefiting crops, trees act as commodities themselves for use in paper, medicine, firewood, etc. Growing coffee plants alongside other tree species in Mexico is a common practice of agroforestry.

Coffee is a shade-loving crop, and is traditionally shade-grown. In India, it is often grown under a natural forest canopy, replacing the shrub layer. A different polyculture system is used for coffee in Mexico, where the Coffea bushes are grown under leguminous trees in the genus Inga.

One approach to sustainability is to develop polyculture systems by breeding perennial crop varieties of traditional annual arable crops. Perennial crops require less tillage and often have longer roots than annual varieties, helping to reduce soil erosion and tolerate drought. Such varieties are being developed for rice, wheat, sorghum, pigeon pea, barley, and sunflowers. If these can be combined in polyculture with a leguminous cover crop such as alfalfa, fixation of nitrogen will be added to the system, reducing the need for fertilizer and pesticides.

Ducks with free access to rice paddies provide an additional source of income, eat weeds that would restrict rice growth, and manure the fields, reducing the need for fertilizer.

Some traditional systems have combined polyculture with sustainability. In South-East Asia, rice-fish systems on rice paddies have raised freshwater fish as well as rice, producing a valuable additional crop and reducing eutrophication of neighbouring rivers. A variant in Indonesia combines rice, fish, ducks and water fern for a resilient and productive permaculture system; the ducks eat the weeds that would otherwise limit rice growth, saving labour and herbicides, while the duck and fish manure substitute for fertilizer.

Integrated aquaculture

Integrated aquaculture is a form of aquaculture in which cultures of fish or shrimp are grown together with seaweed, shellfish, or micro-algae. Mono-species aquaculture, a form of aquaculture where only members of the species are grown together, poses several problems for farmers and the environment. The harvesting of seaweed crops in monocultures, for example, releases nitrates into the water and can lead to severe eutrophication as has occurred in the Venice Lagoon. In terms of seafood growth, the greatest problem in monocultures is the high cost of feed, which accounts for about half of production costs. However, more than half of seafood feed is shown to go to waste and can lead to further problems with excess nitrogen release and eutrophication or algal blooms of freshwater. Many technological approaches to lowering these harmful environmental effects such as bacterial bio-filters have proved to consume high levels of energy and be economically costly.

As such, many farmers have transitioned towards integrated aquaculture. In integrated aquaculture farms, plants serve a dual purpose, acting as food for the sea animals and as a water filtration device for the surrounding environment by absorbing nitrates and excess oxygen. Nutrients can be recycled between plants and animals, reducing the need for chemical nutrient supplements. Plants that are grown alongside seafood such as seaweed often hold significant commercial value by themselves, so incorporating them into already existing seafood monocultures increases economic value.

Functions

Pest management

Pests are less predominant in polycultures than monocultures due to crop diversity. The lack of concentration of a single crop makes polycultures less appealing to pests who have a strong preference towards a specific crop. These specialized pests will often have more difficulty locating a favorable host plant inside of a polyculture than in a monoculture. If a pest has more generalized preferences, it will leave more quickly to other plants in the polyculture and as such have a lesser effect on any one plant. When pests are present in the nearby area, polycultures consequently experience lower yield loss than monocultures do in a theory known as the associational resistance hypothesis. Because polycultures mimic naturally diverse ecosystems, general pests are less likely to distinguish between polycultures and the surrounding environment as well. As such, pests travel more freely between the two environments, and have a relative smaller in presence in polycultures to begin with.

Because of the diversity of plants in a polyculture, natural enemies, or predators, of pests are often attracted to the polyculture alongside pests themselves as well. These natural enemies help suppress pest populations while doing no harm to the plants themselves.

Disease control

Plant diseases are less predominant in polycultures than monocultures. The disease-diversity hypothesis states that a greater diversity of plants leads to a decreased severity of disease. Because different plants are susceptible to different diseases, if a disease negatively impacts one crop, it will not necessarily spread to another and so the overall impact is contained. However, the type of disease and the susceptibility of the specific plants inside the polyculture to a particular disease can vary greatly.

Weed management

Both the density of crops and the diversity affect weed growth in polycultures. Having a greater density of plants reduces the available water, sunlight, and nutrient concentrations in the environment. Such a reduction is heightened with greater crop diversity as more potential resources are fully utilized. This level of competition makes polycultures particularly inhospitable to weeds.

When they do grow, weeds can help polycultures, assisting in pest management by attracting natural enemies of pests. They can also act as hosts to arthropods that are beneficial to other plants in the polyculture.

Sequestering carbon

A polyculture farming system that sequesters carbon is regenerative ocean farming. It grows a mix of seaweeds and shellfish for harvest, while helping to regenerate and restore local habitats like reef ecosystems.

Advantages

Sustainability

Applying pesticides to crops in a monoculture: some of these pesticides will likely end up in water sources and the atmosphere where they can pose serious health and environmental harm. Polycultures attract fewer pests than monocultures and experience less yield loss even when pests are present, often eliminating the need for pesticides.

Because polycultures use methods of pest, disease, and weed control that do not rely on human intervention, they do not release pesticides into the environment. Fertilizer use is reduced as well, as diverse plants more fully share and use all available soil and atmospheric nutrients. As such, environmental impacts such as eutrophication of fresh water or the presence of excess atmospheric nitrogen are greatly reduced.

Other negative impacts of modern agriculture are similarly reduced. Excessive tillage occurs in most modern agricultural practices, but removes essential microbes and nutrients from the soil that are conserved in polycultures, especially permacultures. Because polyculture relies on natural systems of crop maintenance, farmers save money on machinery. By growing multiple plants or animals together in the same space, agricultural land, a critical resource worldwide, taking up 40% of the world's land area, is used more productively.

Polyculture increases local biodiversity. Increasing crop diversity can increase pollination in nearby environments, as diverse plants attract a broader array of pollinators. This is one example of reconciliation ecology, or accommodating biodiversity within human landscapes. This may also form part of a biological pest control program.

Human health

The chemicals used in monoculture food production can be directly harmful to human health when released into the environment. Nitrogen is a chemical found in especially high concentrations in fertilizers. Nitrates from these fertilizers often become integrated in water sources due to agricultural runoff. The consumption of nitrates at high doses has been shown to lead to methemoglobinemia in infants.

Many of the crops consumed today are calorie-rich crops that can lead to illnesses such as obesity, hypertension, and type II diabetes. Because it encourages plant diversity, polyculture can help increase diet diversity by incorporating non-traditional foods into agriculture and people's diets.

Effectiveness

The effects of interspecific competition and intraspecific competition can cause great damage to plants in certain polycultures. In order for a polyculture to be effective, the diverse species that are a part of it must have distinct biological needs such as absorbing different nutrients or requiring different amounts of sunlight as stated by the competitive exclusion principle. Due to the large number of plant species that are cultivated by humans, finding and testing combinations of plants where interspecific and intraspecific competition do not significantly negatively affect the individual plants is extremely difficult. As such, for crops where historic polycultures do not exist, such a multiplicity makes the creation of new polycultures a significant issue.

Crop yield is also an issue in polycultures. While a polyculture produces more biomass overall than a monoculture, individual crops inside of the polyculture are not as prevalent. When there is a focal crop whose cultivation is especially important for a society a lower yield for a certain crop may pose food availability issues.

Similarly, while diseases and pests affect a polyculture less as a group, they do not necessarily have a decreased effect on a focal crop. If targeted by a specialized pest or disease, a focal crop in a polyculture will likely experience the same yield loss as its monoculture counterpart.

Polyculture also often requires more labor.

 

Thursday, September 15, 2022

Chimera (genetics)

From Wikipedia, the free encyclopedia

Two-colored rose chimera

A genetic chimerism or chimera (/kˈmɪərə, kə-/ ky-MEER-ə, kə-) is a single organism composed of cells with more than one distinct genotype. In animals, this means an individual derived from two or more zygotes, which can include possessing blood cells of different blood types, subtle variations in form (phenotype) and, if the zygotes were of differing sexes, then even the possession of both female and male sex organs (this is just one of many different phenomena that may result in intersex conditions). Animal chimeras are produced by the merger of two (or more) embryos. In plant chimeras, however, the distinct types of tissue may originate from the same zygote, and the difference is often due to mutation during ordinary cell division. Normally, genetic chimerism is not visible on casual inspection; however, it has been detected in the course of proving parentage.

Another way that chimerism can occur in animals is by organ transplantation, giving one individual tissues that developed from a different genome. For example, transplantation of bone marrow often determines the recipient's ensuing blood type.

Etymology

While German dermatologist Alfred Blaschko described Blaschko's lines in 1901, the genetic science took until the 1930s to approach a vocabulary for the phenomenon. The term genetic chimera has been used at least since the 1944 article of Belgovskii.

Animals

An animal chimera is a single organism that is composed of two or more different populations of genetically distinct cells that originated from different zygotes involved in sexual reproduction. If the different cells have emerged from the same zygote, the organism is called a mosaic. Innate chimeras are formed from at least four parent cells (two fertilised eggs or early embryos fused together). Each population of cells keeps its own character and the resulting organism is a mixture of tissues. Cases of human chimerism have been documented.

This condition is either innate or it is synthetic, acquired for example through the infusion of allogeneic hematopoietic cells during transplantation or transfusion.

In nonidentical twins, innate chimerism occurs by means of blood-vessel anastomoses. The likelihood of offspring being a chimera is increased if it is created via in vitro fertilisation. Chimeras can often breed, but the fertility and type of offspring depends on which cell line gave rise to the ovaries or testes; varying degrees of intersex differences may result if one set of cells is genetically female and another genetically male.

Tetragametic chimerism

African violets exhibiting chimerism

Tetragametic chimerism is a form of congenital chimerism. This condition occurs through the fertilization of two separate ova by two sperm, followed by aggregation of the two at the blastocyst or zygote stages. This results in the development of an organism with intermingled cell lines. Put another way, the chimera is formed from the merging of two nonidentical twins (a similar merging presumably occurs with identical twins, but as their genotypes are not significantly distinct, the resulting individual would not be considered a chimera). As such, they can be male, female, or have mixed intersex characteristics.

As the organism develops, it can come to possess organs that have different sets of chromosomes. For example, the chimera may have a liver composed of cells with one set of chromosomes and have a kidney composed of cells with a second set of chromosomes. This has occurred in humans, and at one time was thought to be extremely rare although more recent evidence suggests that this is not the case.

This is particularly true for the marmoset. Recent research shows most marmosets are chimeras, sharing DNA with their fraternal twins. 95% of marmoset fraternal twins trade blood through chorionic fusions, making them hematopoietic chimeras.

Most chimeras will go through life without realizing they are chimeras. The difference in phenotypes may be subtle (e.g., having a hitchhiker's thumb and a straight thumb, eyes of slightly different colors, differential hair growth on opposite sides of the body, etc.) or completely undetectable. Chimeras may also show, under a certain spectrum of UV light, distinctive marks on the back resembling that of arrow points pointing downwards from the shoulders down to the lower back; this is one expression of pigment unevenness called Blaschko's lines.

Affected persons may be identified by the finding of two populations of red cells or, if the zygotes are of opposite sex, ambiguous genitalia and intersex alone or in combination; such persons sometimes also have patchy skin, hair, or eye pigmentation (heterochromia). If the blastocysts are of opposite sex, genitals of both sexes may be formed: either ovary and testis, or combined ovotestes, in one rare form of intersex, a condition previously known as true hermaphroditism.

Note that the frequency of this condition does not indicate the true prevalence of chimerism. Most chimeras composed of both male and female cells probably do not have an intersex condition, as might be expected if the two cell populations were evenly blended throughout the body. Often, most or all of the cells of a single cell type will be composed of a single cell line, i.e. the blood may be composed predominantly of one cell line, and the internal organs of the other cell line. Genitalia produce the hormones responsible for other sex characteristics.

Natural chimeras are almost never detected unless they exhibit abnormalities such as male/female or hermaphrodite characteristics or uneven skin pigmentation. The most noticeable are some male tortoiseshell cats and calico cats (although most male tortoiseshells have an extra X chromosome responsible for the colouration) or animals with ambiguous sex organs.

The existence of chimerism is problematic for DNA testing, a fact with implications for family and criminal law. The Lydia Fairchild case, for example, was brought to court after DNA testing apparently showed that her children could not be hers. Fraud charges were filed against her and her custody of her children was challenged. The charge against her was dismissed when it became clear that Lydia was a chimera, with the matching DNA being found in her cervical tissue. Another case was that of Karen Keegan, who was also suspected (initially) of not being her children's biological mother, after DNA tests on her adult sons for a kidney transplant she needed, seemed to show she was not their mother.

The tetragametic state has important implications for organ or stem cell transplantation. Chimeras typically have immunologic tolerance to both cell lines.

Microchimerism

Microchimerism is the presence of a small number of cells that are genetically distinct from those of the host individual. Most people are born with a few cells genetically identical to their mothers' and the proportion of these cells goes down in healthy individuals as they get older. People who retain higher numbers of cells genetically identical to their mother's have been observed to have higher rates of some autoimmune diseases, presumably because the immune system is responsible for destroying these cells and a common immune defect prevents it from doing so and also causes autoimmune problems. The higher rates of autoimmune diseases due to the presence of maternally-derived cells is why in a 2010 study of a 40-year-old man with scleroderma-like disease (an autoimmune rheumatic disease), the female cells detected in his blood stream via FISH (fluorescence in situ hybridization) were thought to be maternally-derived. However, his form of microchimerism was found to be due to a vanished twin, and it is unknown whether microchimerism from a vanished twin might predispose individuals to autoimmune diseases as well. Mothers often also have a few cells genetically identical to those of their children, and some people also have some cells genetically identical to those of their siblings (maternal siblings only, since these cells are passed to them because their mother retained them).

Symbiotic chimerism in anglerfish

Chimerism occurs naturally in adult Ceratioid anglerfish and is in fact a natural and essential part of their life cycle. Once the male achieves adulthood, it begins its search for a female. Using strong olfactory (or smell) receptors, the male searches until it locates a female anglerfish. The male, less than an inch in length, bites into her skin and releases an enzyme that digests the skin of both his mouth and her body, fusing the pair down to the blood-vessel level. While this attachment has become necessary for the male's survival, it will eventually consume him, as both anglerfish fuse into a single hermaphroditic individual. Sometimes in this process, more than one male will attach to a single female as a symbiote. In this case, they will all be consumed into the body of the larger female angler. Once fused to a female, the males will reach sexual maturity, developing large testicles as their other organs atrophy. This process allows for sperm to be in constant supply when the female produces an egg, so that the chimeric fish is able to have a greater number of offspring.

Germline chimerism

Germline chimerism occurs when the germ cells (for example, sperm and egg cells) of an organism are not genetically identical to its own. It has been recently discovered that marmosets can carry the reproductive cells of their (fraternal) twin siblings due to placental fusion during development. (Marmosets almost always give birth to fraternal twins.)

Artificial chimerism

Chimeric trait distribution by generation

Artificial chimerism falls under the artificial category in which a chimera can exist. An individual that falls under this classification possesses two different sets of genetic pedigrees: one that was inherited genetically at the time of the formation of the human embryo and the other that was intentionally introduced through a medical procedure known as transplantation. Specific types of transplants that could induce this condition include bone marrow transplants and organ transplants, as the recipient's body essentially works to permanently incorporate the new blood stem cells into it.

An example of artificial chimerism in animals are the quail-chick chimeras. By utilizing  transplantation and ablation in the chick embryo stage, the neural tube and the neural crest cells of the chick were ablated, and replaced with the same parts from a quail. Once hatched, the quail feathers were visibly apparent around the wing area, whereas the rest of the chick's body was made of its own chicken cells.

Humans

Chimerism has been documented in humans in several instances.

  • The Dutch sprinter Foekje Dillema was expelled from the 1950 national team after she refused a mandatory sex test in July 1950; later investigations revealed a Y-chromosome in her body cells, and the analysis showed that she was probably a 46,XX/46,XY mosaic female.
  • In 1953, a human chimera was reported in the British Medical Journal. A woman was found to have blood containing two different blood types. Apparently this resulted from her twin brother's cells living in her body. A 1996 study found that such blood group chimerism is not rare.
  • Another report of a human chimera was published in 1998, where a male human had some partially developed female organs due to chimerism. He had been conceived by in-vitro fertilization.
  • In 2002, Lydia Fairchild was denied public assistance in Washington state when DNA evidence appeared to show that she was not the mother of her children. A lawyer for the prosecution heard of a human chimera in New England, Karen Keegan, and suggested the possibility to the defense, who were able to show that Fairchild, too, was a chimera with two sets of DNA, and that one of those sets could have been the mother of the children.
  • In 2002, an article in the New England Journal of Medicine describes a woman in whom tetragametic chimerism was unexpectedly identified after undergoing preparations for kidney transplant that required the patient and her immediate family to undergo histocompatibility testing, the result of which suggested that she was not the biological mother of two of her three children.
  • In 2009, singer Taylor Muhl discovered that what was always thought to be a large birthmark on her torso was actually caused by chimerism.
  • In 2017, a human-pig chimera was reported to have been created; the chimera was also reported to have 0.001% human cells, with the balance being pig.
  • In 2021, a human-monkey chimera was created as a joint project between the Salk Institute in the USA and Kunming University in China and published in the journal, Cell. This involved injecting human stem cells into monkey embryos. The embryos were only allowed to grow for a few days, but the study demonstrated that some of these embryos still had human stem cells surviving at the end of the experiments. Because humans are more closely related to monkeys than other animals, it means there is more chance of the chimeric embryos surviving for longer periods so that organs can develop. The project has opened up possibilities into organ transplantation as well as ethical concerns particularly concerning human brain development in primates.

Hermaphrodites

  • A hypothetical scenario in which it could be possible for a human to self-fertilize. If a human chimera is formed from a male and female zygote fusing into a single embryo, giving an individual functional gonadal tissue of both types, such a self-fertilization is feasible. Indeed, it is known to occur in non-human species where hermaphroditic animals are common. However, no such case of functional self-fertilization has ever been documented in humans. Some biologists have even said hermaphroditism does not occur in mammals, especially in humans.

Bone marrow recipients

  • Several cases of unusual chimera phenomena have been reported in bone marrow recipients.
    • In 2019, the blood and seminal fluid of a man in Reno, Nevada (who had undergone a vasectomy), exhibited only the genetic content of his bone marrow donor. Swabs from his lips, cheek and tongue showed mixed DNA content.
    • The DNA content of semen from an assault case in 2004 matched that of a man who had been in prison at the time of the assault, but who had been a bone marrow donor for his brother, who was later determined to have committed the crime.
    • In 2008, a man was killed in a traffic accident that occurred in Seoul, South Korea. In order to identify him, his DNA was analyzed. Results revealed that the DNA of his blood, along with some of his organs, appeared to show that he was female. It was later determined that he had received a bone marrow transplant from his daughter.

Chimera identification

Chimerism is so rare that there have only been 100 confirmed cases in humans. However, this may be due to the fact that humans might not be aware that they have this condition to begin with. There are usually no signs or symptoms for chimerism other than a few physical symptoms such as hyper-pigmentation, hypo-pigmentation, or possessing two different colored eyes. However, these signs do not necessarily mean an individual is a chimera and should only be seen as possible symptoms. Again, forensic investigation or curiosity over a failed maternity/paternity DNA test usually leads to the accidental discovery of this condition. By simply undergoing a DNA test, which usually consists of either a swift cheek swab or a blood test, the discovery of the once unknown second genome is made, therefore identifying that individual as a chimera.

Research

The first known primate chimeras are the rhesus monkey twins, Roku and Hex, each having six genomes. They were created by mixing cells from totipotent four-cell morulas; although the cells never fused, they worked together to form organs. It was discovered that one of these primates, Roku, was a sexual chimera; as four percent of Roku's blood cells contained two x chromosomes.

A major milestone in chimera experimentation occurred in 1984 when a chimeric sheep–goat was produced by combining embryos from a goat and a sheep, and survived to adulthood.

In August 2003, researchers at the Shanghai Second Medical University in China reported that they had successfully fused human skin cells and rabbit ova to create the first human chimeric embryos. The embryos were allowed to develop for several days in a laboratory setting, and then destroyed to harvest the resulting stem cells. In 2007, scientists at the University of Nevada School of Medicine created a sheep whose blood contained 15% human cells and 85% sheep cells.

On January 22, 2019 the National Society of Genetic Counselors released an article — Chimerism Explained: How One Person Can Unknowingly Have Two Sets of DNA, where they state “Tetragametic Chimerism, where a twin pregnancy evolves into one child, is currently believed to be one of the rarer forms. However, we know that 20 to 30% of singleton pregnancies were originally a twin or a multiple pregnancy. Due to this statistic, it is quite possible that tetragametic chimerism is more common than current data implies”.

Sponges

Chimerism has been found in some species of marine sponges. Four distinct genotypes have been found in a single individual, and there is potential for even greater genetic heterogeneity. Each genotype functions independently in terms of reproduction, but the different intra-organism genotypes behave as a single large individual in terms of ecological responses like growth.

Mice

A chimeric mouse with her offspring, which carry the agouti coat color gene; note her pink eye

Chimeric mice are important animals in biological research, as they allow for the investigation of a variety of biological questions in an animal that has two distinct genetic pools within it. These include insights into problems such as the tissue specific requirements of a gene, cell lineage, and cell potential.

The general methods for creating chimeric mice can be summarized either by injection or aggregation of embryonic cells from different origins. The first chimeric mouse was made by Beatrice Mintz in the 1960s through the aggregation of eight-cell-stage embryos. Injection on the other hand was pioneered by Richard Gardner and Ralph Brinster who injected cells into blastocysts to create chimeric mice with germ lines fully derived from injected embryonic stem cells (ES cells). Chimeras can be derived from mouse embryos that have not yet implanted in the uterus as well as from implanted embryos. ES cells from the inner cell mass of an implanted blastocyst can contribute to all cell lineages of a mouse including the germ line. ES cells are a useful tool in chimeras because genes can be mutated in them through the use of homologous recombination, thus allowing gene targeting. Since this discovery occurred in 1988, ES cells have become a key tool in the generation of specific chimeric mice.

Underlying biology

The ability to make mouse chimeras comes from an understanding of early mouse development. Between the stages of fertilization of the egg and the implantation of a blastocyst into the uterus, different parts of the mouse embryo retain the ability to give rise to a variety of cell lineages. Once the embryo has reached the blastocyst stage, it is composed of several parts, mainly the trophectoderm, the inner cell mass, and the primitive endoderm. Each of these parts of the blastocyst gives rise to different parts of the embryo; the inner cell mass gives rise to the embryo proper, while the trophectoderm and primitive endoderm give rise to extra embryonic structures that support growth of the embryo. Two- to eight-cell-stage embryos are competent for making chimeras, since at these stages of development, the cells in the embryos are not yet committed to give rise to any particular cell lineage, and could give rise to the inner cell mass or the trophectoderm. In the case where two diploid eight-cell-stage embryos are used to make a chimera, chimerism can be later found in the epiblast, primitive endoderm, and trophectoderm of the mouse blastocyst.

It is possible to dissect the embryo at other stages so as to accordingly give rise to one lineage of cells from an embryo selectively and not the other. For example, subsets of blastomeres can be used to give rise to chimera with specified cell lineage from one embryo. The Inner Cell Mass of a diploid blastocyst, for example, can be used to make a chimera with another blastocyst of eight-cell diploid embryo; the cells taken from the inner cell mass will give rise to the primitive endoderm and to the epiblast in the chimera mouse. From this knowledge, ES cell contributions to chimeras have been developed. ES cells can be used in combination with eight-cell-and two-cell-stage embryos to make chimeras and exclusively give rise to the embryo proper. Embryos that are to be used in chimeras can be further genetically altered in order to specifically contribute to only one part of chimera. An example is the chimera built off of ES cells and tetraploid embryos, which are artificially made by electrofusion of two two-cell diploid embryos. The tetraploid embryo will exclusively give rise to the trophectoderm and primitive endoderm in the chimera.

Methods of production

There are a variety of combinations that can give rise to a successful chimera mouse and – according to the goal of the experiment – an appropriate cell and embryo combination can be picked; they are generally but not limited to diploid embryo and ES cells, diploid embryo and diploid embryo, ES cell and tetraploid embryo, diploid embryo and tetraploid embryo, ES cells and ES cells. The combination of embryonic stem cell and diploid embryo is a common technique used for the making of chimeric mice, since gene targeting can be done in the embryonic stem cell. These kinds of chimeras can be made through either aggregation of stem cells and the diploid embryo or injection of the stem cells into the diploid embryo. If embryonic stem cells are to be used for gene targeting to make a chimera, the following procedure is common: a construct for homologous recombination for the gene targeted will be introduced into cultured mouse embryonic stem cells from the donor mouse, by way of electroporation; cells positive for the recombination event will have antibiotic resistance, provided by the insertion cassette used in the gene targeting; and be able to be positively selected for. ES cells with the correct targeted gene are then injected into a diploid host mouse blastocyst. Then, these injected blastocysts are implanted into a pseudo pregnant female surrogate mouse, which will bring the embryos to term and give birth to a mouse whose germline is derived from the donor mouse's ES cells. This same procedure can be achieved through aggregation of ES cells and diploid embryos, diploid embryos are cultured in aggregation plates in wells where single embryos can fit, to these wells ES cells are added the aggregates are cultured until a single embryo is formed and has progressed to the blastocyst stage, and can then be transferred to the surrogate mouse.

Plants

Ficus with chlorophyll-deficient cell zones

Structure

The distinction between sectorial, mericlinal and periclinal plant chimeras are widely used.

Graft chimeras

Taxus mosaic

These are produced by grafting genetically different parents, different cultivars or different species (which may belong to different genera). The tissues may be partially fused together following grafting to form a single growing organism that preserves both types of tissue in a single shoot. Just as the constituent species are likely to differ in a wide range of features, so the behavior of their periclinal chimeras is like to be highly variable. The first such known chimera was probably the Bizzaria, which is a fusion of the Florentine citron and the sour orange. Well-known examples of a graft-chimera are Laburnocytisus 'Adamii', caused by a fusion of a Laburnum and a broom, and "Family" trees, where multiple varieties of apple or pear are grafted onto the same tree. Many fruit trees are cultivated by grafting the body of a sapling onto a rootstock.

Chromosomal chimeras

These are chimeras in which the layers differ in their chromosome constitution. Occasionally, chimeras arise from loss or gain of individual chromosomes or chromosome fragments owing to misdivision. More commonly cytochimeras have simple multiple of the normal chromosome complement in the changed layer. There are various effects on cell size and growth characteristics.

Nuclear gene-differential chimeras

These chimeras arise by spontaneous or induced mutation of a nuclear gene to a dominant or recessive allele. As a rule, one character is affected at a time in the leaf, flower, fruit, or other parts.

Plastid gene-differential chimeras

These chimeras arise by spontaneous or induced mutation of a plastid gene, followed by the sorting-out of two kinds of plastid during vegetative growth. Alternatively, after selfing or nucleic acid thermodynamics, plastids may sort-out from a mixed egg or mixed zygote respectively. This type of chimera is recognized at the time of origin by the sorting-out pattern in the leaves. After sorting-out is complete, periclinal chimeras are distinguished from similar looking nuclear gene-differential chimeras by their non-mendelian inheritance. The majority of variegated-leaf chimeras are of this kind.

All plastid gene- and some nuclear gene-differential chimeras affect the color of the plasmids within the leaves, and these are grouped together as chlorophyll chimeras, or preferably as variegated leaf chimeras. For most variegation, the mutation involved is the loss of the chloroplasts in the mutated tissue, so that part of the plant tissue has no green pigment and no photosynthetic ability. This mutated tissue is unable to survive on its own, but it is kept alive by its partnership with normal photosynthetic tissue. Sometimes chimeras are also found with layers differing in respect of both their nuclear and their plastid genes.

Origins

There are multiple reasons to explain the occurrence of plant chimera during plant recovery stage:

(1) The process of shoot organogenesis starts form the multicellular origin.

(2) The endogenous tolerance leads to the ineffectiveness of the weak selective agents.

(3) A self-protection mechanism (cross protection). Transformed cells serve as guards to protect the untransformed ones.

(4) The observable characteristic of transgenic cells may be a transient expression of the marker gene. Or it may due to the presence of agrobacterium cells.

Detection

Untransformed cells should be easy to detect and remove to avoid chimeras. This is because it is important to maintain the stable ability of the transgenic plants across different generations. Reporter genes such as GUS and Green Fluorescent Protein (GFP) are utilized in combination with plant selective markers (herbicide, antibody etc.) However, GUS expression depends on the plant development stage and GFP may be influenced by the green tissue autofluorescence. Quantitative PCR could be an alternative method for chimera detection.

Viruses

Boiling Springs Lake, California, is where the first natural chimeric virus was found in 2012.
 

In 2012, the first example of a naturally-occurring RNA-DNA hybrid virus was unexpectedly discovered during a metagenomic study of the acidic extreme environment of Boiling Springs Lake that is in Lassen Volcanic National Park, California. The virus was named BSL-RDHV (Boiling Spring Lake RNA DNA Hybrid Virus). Its genome is related to a DNA circovirus, which usually infect birds and pigs, and a RNA tombusvirus, which infect plants. The study surprised scientists, because DNA and RNA viruses vary and the way the chimera came together was not understood.

Other viral chimeras have also been found, and the group is known as the CHIV viruses ("chimeric viruses").

Ethics and legislation

Ethics

The US and Western Europe have strict codes of ethics and regulations in place that expressly forbid certain subsets of experimentation using human cells, though there is a vast difference in the regulatory framework. Through the creation of human chimeras comes the question: where does society now draw the line of humanity? This question poses serious legal and moral issues, along with creating controversy. Chimpanzees, for example, are not offered any legal standing, and are put down if they pose a threat to humans. If a chimpanzee is genetically altered to be more similar to a human, it may blur the ethical line between animal and human. Legal debate would be the next step in the process to determine whether certain chimeras should be granted legal rights. Along with issues regarding the rights of chimeras, individuals have expressed concern about whether or not creating human chimeras diminishes the "dignity" of being human.

Legislation

The Human Chimera Prohibition Act

On 11 July 2005, a bill known as The Human Chimera Prohibition Act, was introduced into the United States Congress by Senator Samuel Brownback; however, it died in Congress sometime in the next year. The bill was introduced based on the findings that science has progressed to the point where the human and nonhuman species can be merged to create new forms of life. Because of this, serious ethical issues arise as this blurs the line between humans and other animals, and according to the bill with this blurring of the lines comes a show of disrespect for human dignity. The final claim brought up in The Human Chimera Prohibition Act was that there is an increasing amount of zoonotic diseases. With that being said, the creation of human-animal chimeras can allow these diseases to reach humans.

On 22 August 2016, another bill, The Human-Animal Chimera Prohibition Act of 2016, was introduced to the United States House of Representatives by Christopher H. Smith. It identifies a chimera as:

  • a human embryo into which a nonhuman cell or cells (or the component parts thereof) have been introduced to render the embryo's membership in the species Homo sapiens uncertain;
  • a chimera human/animal embryo produced by fertilizing a human egg with nonhuman sperm;
  • chimera human/animal embryo produced by fertilizing a nonhuman egg with human sperm;
  • an embryo produced by introducing a nonhuman nucleus into a human egg;
  • an embryo produced by introducing a human nucleus into a nonhuman egg;
  • an embryo containing at least haploid sets of chromosomes from both a human and a nonhuman life form;
  • a nonhuman life form engineered such that human gametes develop within the body of a nonhuman life form; or
  • a nonhuman life form engineered such that it contains a human brain or a brain derived wholly or predominantly from human neural tissues.

The bill prohibits the attempts to create a human-animal chimera, the transfer or attempt to transfer a human embryo into a nonhuman womb, the transfer or attempt to transfer a nonhuman embryo into a human womb, and the transport or receive of any purpose of an animal chimera. Penalties for violations of this bill include fines and/or imprisonment of up to 10 years. The bill was referred to the Subcommittee on Crime, Terrorism, Homeland Security, and Investigations on October 11, 2016, but died there.

Inequality (mathematics)

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