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Biological determinism, also known as genetic determinism is the belief that human behavior is controlled by an individual's genes or some component of their physiology, generally at the expense of the role of the environment, whether in embryonic development or in learning. Genetic reductionism is a similar concept, but it is distinct from genetic determinism in that the former refers to the level of understanding, while the latter refers to the supposedly causal role of genes. It has been associated with movements in science and society including eugenics, scientific racism, the debate around the heritability of IQ, the biological basis for gender roles, and the sociobiology debate. 
 
In 1892 August Weismann proposed in his germ plasm theory that heritable information is transmitted only via germ cells, which he thought contained determinants (genes). Francis Galton, supposing that undesirable traits such as club foot and criminality were inherited, advocated eugenics, aiming to prevent supposedly defective people from breeding. Samuel George Morton and Paul Broca attempted to relate the cranial capacity (internal skull volume) to skin colour, intending to show that white people were superior. Other workers such as H. H. Goddard, and Robert Yerkes attempted to measure people's intelligence and to show that the resulting scores were heritable, again to demonstrate the supposed superiority of people with white skin.

Galton popularized the phrase nature and nurture, later often used to characterize the heated debate over whether genes or the environment determined human behavior. Scientists such as ecologists and behavioural geneticists now see it as obvious that both factors are essential, and that they are intertwined.

Late in the 20th century, the determinism of gender roles was debated by geneticists and others. Biologists such as John Money and Anke Ehrhardt attempted to describe femininity and homosexuality according to then-current social standards; against this, the evolutionary biologist Richard Lewontin and others argued that clothing and other preferences vary in different societies. The biologist E. O. Wilson founded the discipline of sociobiology, founded on observations of animals such as social insects, controversially suggesting that its explanations of social behaviour might apply to humans.

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