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Pandemic predictions and preparations prior to COVID-19 were pandemic predictions made and preparations carried out in the early twenty-first century prior to the 2019–20 COVID-19 pandemic. The World Health Organization (WHO) and the World Bank warned about the risk of pandemics throughout the 2000s and the 2010s, especially after the 2002–2004 SARS outbreak with the Global Preparedness Monitoring Board releasing its first report in late 2019. The WHO coined the term, Disease X in 2018 so the preparations for the next, at-the-time unknown pandemic could be undertaken. In 2005–2006, prior to the 2009 swine flu pandemic and during the decade following the pandemic, the governments in the United States and France prepared stocks of pandemic equipment and depleted their stocks.
 
During the COVID-19 pandemic itself, several reports underlined the inability of national governments to learn from the previous disease outbreaks, epidemics and pandemics. According to Richard Horton, editor-in-chief of The Lancet, the United Kingdom "failed to act upon the lessons" of the SARS outbreak. Horton described the "global response to SARS-CoV-2 [as] the greatest science policy failure in a generation".

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