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Tuesday, February 10, 2015

Cancer research


From Wikipedia, the free encyclopedia


Cancer research is basic research into cancer in order to identify causes and develop strategies for prevention, diagnosis, treatments and cure.

Cancer research ranges from epidemiology, molecular bioscience to the performance of clinical trials to evaluate and compare applications of the various cancer treatment. These applications include surgery, radiation therapy, chemotherapy, hormone therapy, Immunotherapy and combined treatment modalities such as chemo-radiotherapy. Starting in the mid-1990s, the emphasis in clinical cancer research shifted towards therapies derived from biotechnology research, such as cancer immunotherapy and gene therapy.

Areas of research

Cause

Early research on the cause of cancer was summarized by Haddow in 1958.[1] The first chemical carcinogen was identified in 1928-29 as 1:2-5:6-dibenzanthracene, and the carcinogeneic substance in pitch was identified as 3:4-benzopyrene in 1933. Haddow concluded that “there can be little doubt of the importance of their [chemical] combination with the genetical material” as the source of the chemical mechanism of action of carcinogens. Brookes and Lawley, in 1964, summarized ongoing research into the causes of cancer.[2] They referred to the competing hypotheses that carcinogens reacted mainly with proteins versus mainly with DNA. The direct research of Brookes and Lawley, testing carcinogenic hydrocarbons, indicated that they react with DNA. McCann et al.[3] in 1975 and McCann and Ames, in 1976,[4] tested 175 known carcinogens for interaction with DNA sufficient to cause mutations in their new Salmonella/microsome test. This test uses bacteria as sensitive indicators of DNA damage. They found that 90% of known carcinogens caused mutations in their test. They indicated that the carcinogens that did not cause mutations in their assay were likely due to the need for the carcinogens to be activated by enzymes not available in their system.

By 1981, Doll and Peto conducted an epidemiological study in which they compared cancer rates for 37 specific cancers in the United States to rates for these cancers in populations in which the incidence of these cancers is low.[5] The populations compared with US populations included Norwegians, Nigerians, Japanese, British, and Israeli Jews. Their conclusion was that 75 - 80% of the cases of cancer in the United States were likely avoidable. The avoidable sources of cancer included tobacco, alcohol, diet (especially meat and fat), food additives, occupational exposures (including aromatic amines, benzene, heavy metals, vinyl chloride), pollution, industrial products, medicines and medical procedures, UV light from the sun, exposure to medical x-rays, and infection. Many of these sources of cancer are DNA damaging agents.

More recent research, indicating both the role of DNA damage in causing cancer and other factors including reduced expression of DNA repair genes by epigenetic alterations (allowing DNA damages to accumulate) are summarized in Carcinogenesis and in an article by Bernstein et al. in 2013.[6]

Research into the cause of cancer involves many different disciplines including genetics, diet, environmental factors (i.e. chemical carcinogens). In regard to investigation of causes and potential targets for therapy, the route used starts with data obtained from clinical observations, enters basic research, and, once convincing and independently confirmed results are obtained, proceeds with clinical research, involving appropriately designed trials on consenting human subjects, with the aim to test safety and efficiency of the therapeutic intervention method. An important part of basic research is characterization of the potential mechanisms of carcinogenesis, in regard to the types of genetic and epigenetic changes that are associated with cancer development. The mouse is often used as a mammalian model for manipulation of the function of genes that play a role in tumor formation, while basic aspects of tumor initiation, such as mutagenesis, are assayed on cultures of bacteria and mammalian cells.

Important cell types involved in cancer growth

There are several different cell types that are critical to tumor growth. In particular Endothelial Progenitor Cells are a very important cell population in tumor blood vessel growth. This finding was demonstrated in the high impact factor journals of Science (2008) and Genes and Development (2007)which also showed that Endothelial Progenitor Cells are critical for metastasis and the angiogenesis.[7][8] This importance of endothelial progenitor cells in tumour growth and angiogenesis has been confirmed by a recent publication in Cancer Research (August 2010). This seminal paper has demonstrated that endothelial progenitor cells can be marked using the Inhibitor of DNA Binding 1 (ID1). This novel finding meant that investigators were able to track endothelial progenitor cells from the bone marrow to the blood to the tumour-stroma and even incorporated in tumour vasculature. This finding of endothelial progenitor cells incorporated in tumour vasculature proves the importance of this cell type in blood vessel development in a tumour setting. Furthermore, ablation of the endothelial progenitor cells in the bone marrow lead to a significant decrease in tumour growth and vasculature development. Therefore endothelial progenitor cells are very important in tumour biology and present novel therapeutic targets.[9]

In vitro research using cell lines


Electroporation is used extensively in cancer research for gene and drug delivery. Gemini X2 system manufactured by BTX Harvard Apparatus

In vitro assays allow scientists to conduct studies under reasonable conditions in the lab. In order to study the communication between a tumor cell and a host cell in vitro assays have been created. The use of fragmented chicken heart cells as a host case for nutrients[10] Thus allowing the HeLa cells to, in a sense win, and over take the PHF. In the case of the L tumor cells, they were not able to invade the PHF. Though HeLa cells were able to accomplish invasion after several hours the L cells are structurally different rendering them inadequate. The L cells have much more intercellular free space and do not surround the host cell as tightly as Hela cells. It was concluded that with a tight gap junction nutrients cannot enter the cell allowing the cancer cells to invade. With this information about the gap junction process between host cell and the tumor cell, further studies were conducted in cancer gene therapy with the use of Hela cells and the herpes virus.[11]

Oncogenomics/Genes involved in cancer

The goal of oncogenomics is to identify new oncogenes or tumor suppressor genes that may provide new insights into cancer diagnosis, predicting clinical outcome of cancers, and new targets for cancer therapies. As the Cancer Genome Project stated in a 2004 review article, "a central aim of cancer research has been to identify the mutated genes that are causally implicated in oncogenesis (cancer genes)."[12] The Cancer Genome Atlas project is a related effort investigating the genomic changes associated with cancer, while the COSMIC cancer database documents acquired genetic mutations from hundreds of thousands of human cancer samples.[13]
These large scale projects, involving about 350 different types of tumour, have identified ~130,000 mutations in ~3000 genes that have been mutated in the tumours. The majority occurred in 319 genes of which 286 were tumour suppressor genes and 33 oncogenes.

Several hereditary factors can increase the chance of cancer-causing mutations, including the activation of oncogenes or the inhibition of tumor suppressor genes. The functions of various onco- and tumor suppressor genes can be disrupted at different stages of tumor progression. Mutations in such genes can be used to classify the malignancy of a tumor.

In later stages, tumors can develop a resistance to cancer treatment. The identification of oncogenes and tumor suppressor genes is important to understand tumor progression and treatment success. The role of a given gene in cancer progression may vary tremendously, depending on the stage and type of cancer involved.[14]

Genes and protein products that have been identified by at least two independent publications as being involved in cancer are:[12]

ABI1, ABL2, ACSL6, AF1Q, AF5Q31 (also known as MCEF), AKT1, ARNT, ASPSCR1, ATF1, ATIC, BCL10, BFHD, BIRC3, BMPR1A, BTG1, CBFA2T1, CBFA2T3, CBFB, CCND1, CDC2, CDK4, CHIC2, CHN1, COPEB, COX6C, CTNNB1, CYLD, DDB2, DDIT3, DEK, Eif4a, EIF4A2, EPS15, ERCC2, ERCC3, ERCC5, ERG, ETV4, ETV6, EWSR1, EXT1, EXT2, FANCC, FANCG, FGFR1OP, FGFR3, FH, FIP1L1, FUS, GAS7, GATA1, GMPS, GOLGA5, GPC (gene), GPHN, HIST1H4I, HRAS, HSPCA, IL21R, IIRF4, KRAS2, LASP1, LCP1, LHFP, LMO2, LYL1, MADH4, MEIS1, MLF1, MLH1, MLLT3, MLLT6, MNAT1, MSF, MSH2, MSN, MUTYH, MYC, NCOA4, NF2, NPM1, NRAS, PAX8, PCBD, PDGFB, PHOX2B, PIM1, PLK2, PNUTL1, POU2F1, PPARG, PRCC, PRKACB, PRKAR1A, PTEN, PTPN11, RABEP1, RAD51L1, RAP1GDS1, RARA, RB1, RET, RHOH, RPL22, SBDS, SDHB, SEPTIN6, SET, SH3GL1, SS18L1, SSX1, SSX2, SSX4, STAT3, TAF15, TCF12, TCL1A, TFE3, TFEB, TFG, TFPT, TFRC, TNFRSF6, TP53, TPM3, TPM4, TRIP11, VHL, WAS, WT1, ZNF198, ZNF278, ZNF384, ZNFN1A1

Treatment

Current topics of cancer treatment research include:

Vaccines[edit]

Flaws and vulnerabilities

Newsweek magazine published an article criticising the use of lab rats on cancer research because even though researchers frequently manage to cure lab mice transplanted with human tumors, few of those achievements are relevant to humanity.[19] Oncologist Paul Bunn, from the International Association for the Study of Lung Cancer[20] said: "We put a human tumor under the mouse's skin, and that microenvironment doesn't reflect a person's—the blood vessels, inflammatory cells or cells of the immune system".[19] Fran Visco founder of the National Breast Cancer Coalition completed: "We cure cancer in animals all the time, but not in people."[19]

Most funding for cancer research comes from taxpayers and charities, rather than from profit-making businesses. In the US, less than 30% of all cancer research is funded by commercial researchers such as pharmaceutical companies.[21] Per capita, public spending on cancer research by taxpayers and charities in the US was five times as much in 2002-03 as public spending by taxpayers and charities in the 15 countries then full members of the European Union.[21] As a percentage of GDP, the non-commercial funding of cancer research in the US was four times the amount dedicated to cancer research in Europe.[21] Half of Europe's non-commercial cancer research is funded by charitable organizations.[21]

Cancer research processes have been criticised in many respects. These include, especially in the US, hypercompetition for the financial resources and positions required to conduct science, which seems to suppress the creativity, cooperation, risk-taking, and original thinking required to make fundamental discoveries, unduly favoring low-risk research into small incremental advancements over innovative research that might discover radically new and dramatically improved therapy. Other consequences of today's highly pressured competition for research resources appear to be a substantial number of research publications whose results cannot be replicated, and perverse incentives in research funding that encourage grantee institutions to grow without making sufficient investments in their own faculty and facilities.[22][23][24][25]

Distributed computing

One can share computer time for distributed cancer research projects like Help Conquer Cancer.[26] World Community Grid also had a project called Help Defeat Cancer. Other related projects include the Folding@home and Rosetta@home projects, which focus on groundbreaking protein folding and protein structure prediction research.

Organizations


Richard Branson


From Wikipedia, the free encyclopedia

Sir Richard Branson
5.3.10RichardBransonByDavidShankbone.jpg
Branson at the Time 100 Gala in May 2010
Born Richard Charles Nicholas Branson
(1950-07-18) 18 July 1950 (age 64)[1]
Blackheath, London, England, UK
Residence Necker Island, BVI
Occupation Founder of Virgin Group
Years active 1966–present
Net worth US$4.9 billion (as of October 2014)[2]
Religion None[3]
Spouse(s) Kristen Tomassi (m. 1972–79) (divorced)
Joan Templeman (m. 1989)
Parents Edward James Branson
Eve Branson

Sir Richard Charles Nicholas Branson (born 18 July 1950) is an English businessman and investor. He is best known as the founder of Virgin Group, which comprises more than 400 companies.[4]

At the age of sixteen his first business venture was a magazine called Student.[5] In 1970, he set up a mail-order record business. In 1972, he opened a chain of record stores, Virgin Records, later known as Virgin Megastores. Branson's Virgin brand grew rapidly during the 1980s, as he set up Virgin Atlantic and expanded the Virgin Records music label.

According to the Forbes 2014 list of billionaires, Branson is the seventh richest citizen of the United Kingdom, with an estimated net worth of US$4.9 billion.[2]

Early life

Branson was born in Blackheath, London, the eldest of three children born to barrister Edward James Branson (1918 – 2011), and Eve Branson (born 1924), a former ballet dancer and air hostess.[6][7] Branson has two younger sisters.[8] His grandfather, the Right Honourable Sir George Arthur Harwin Branson, was a judge of the High Court of Justice and a Privy Councillor.[9] Branson was educated at Scaitcliffe School, a prep school in Berkshire, before briefly attending Cliff View House School in Sussex.[10] Branson attended Stowe School, an independent school in Buckinghamshire until the age of sixteen.[10] Branson has dyslexia and had poor academic performance as a student, and on his last day at school, his headmaster, Robert Drayson, told him he would either end up in prison or become a millionaire.[10]

Branson's parents were supportive of his endeavors from an early age.[11]

Career

Record business

Branson started his record business from the crypt of a church where he ran The Student magazine.
Branson interviewed several prominent personalities of the late 1960s for the magazine including Mick Jagger and R. D. Laing.[12] Branson advertised popular records in The Student and it was an overnight success.[13] Trading under the name "Virgin", he sold records for considerably less than the "High Street" outlets, especially the chain W. H. Smith. Branson once said, "There is no point in starting your own business unless you do it out of a sense of frustration." The name "Virgin" was suggested by one of Branson's early employees because they were all new at business.[14] At the time, many products were sold under restrictive marketing agreements that limited discounting, despite efforts in the 1950s and 1960s to limit so-called resale price maintenance.[15]

Branson eventually started a record shop in Oxford Street in London. In 1971, Branson was questioned in connection with the selling of records in Virgin stores that had been declared export stock. The matter was never brought before a court and Branson agreed to repay any unpaid tax and a fine. Branson's mother, Eve, re-mortgaged the family home to help pay the settlement.[14]

The Manor Studio, Richard Branson's recording studio in the manor house at the village of Shipton-on-Cherwell in Oxfordshire.

Earning enough money from his record store, Branson in 1972 launched the record label Virgin Records with Nik Powell and bought a country estate north of Oxford, in which he installed a residential recording studio, The Manor Studio.[16] He leased out studio time to fledgling artists, including multi-instrumentalist Mike Oldfield, whose debut album Tubular Bells (1973) was the first release for Virgin Records and became a chart-topping best-seller.[17]

Virgin signed such controversial bands as the Sex Pistols, which other companies were reluctant to sign. It also won praise for exposing the public to such obscure avant-garde music as Faust and Can. Virgin Records also introduced Culture Club to the music world. In 1982, Virgin purchased the gay nightclub Heaven. In 1991, in a consortium with David Frost, Branson made an unsuccessful bid for three ITV franchisees under the CPV-TV name. The early 1980s also saw his only attempt as a producer—on the novelty record, "Baa, Baa, Black Sheep", by Singing Sheep in association with Doug McLean and Grace McDonald. The recording was a series of sheep baa-ing along to a drum-machine-produced track and reached number 42 in the UK charts in 1982.[18]

In 1992, to keep his airline company afloat, Branson sold the Virgin label to EMI for £500 million.[19] Branson said that he wept when the sale was completed because the record business had been the very start of the Virgin empire. In 1996 he created V2 Records to re-enter the music business, owning 5% himself.[20]

Business ventures

Branson formed Virgin Atlantic Airways in 1984, launched Virgin Mobile in 1999, and Virgin Blue in Australia (now named Virgin Australia) in 2000. He was ninth in the Sunday Times Rich List 2006, worth slightly more than £3 billion. Branson wrote in his autobiography of the decision to start an airline:
My interest in life comes from setting myself huge, apparently unachievable challenges and trying to rise above them ... from the perspective of wanting to live life to the full, I felt that I had to attempt it.
In 1993, Branson took what many saw as being one of his riskier business exploits by entering into the railway business. Virgin Trains won the franchises for the former Intercity West Coast and Cross-Country sectors of British Rail.

Virgin acquired European short-haul airline Euro Belgian Airlines in 1996 and renamed it Virgin Express. In 2006, the airline was merged with SN Brussels Airlines forming Brussels Airlines. It also started a national airline based in Nigeria, called Virgin Nigeria. Another airline, Virgin America, began flying out of San Francisco International Airport in August 2007. Branson has also developed a Virgin Cola brand and even a Virgin Vodka brand, which has not been a very successful enterprise. As a consequence of these lacklustre performers, the satirical British fortnightly magazine Private Eye has been critical of Branson and his companies (see Private Eye image caption).[21]

A series of disputes in the early 1990s caused tension between Virgin Atlantic and British Airways, which viewed Virgin as an emerging competitor. Virgin subsequently accused British Airways of poaching its passengers, hacking its computers, and leaking stories to the press that portrayed Virgin negatively. After the so-called campaign of "dirty tricks", British Airways settled the case, giving £500,000 to Branson, a further £110,000 to his airline, and had to pay legal fees of up to £3million . Branson distributed his compensation (the so-called "BA bonus") among his staff.[22]

On 25 September 2004, Branson announced the signing of a deal under which a new space tourism company, Virgin Galactic, will license the technology behind Spaceship One—funded by Microsoft co-founder Paul Allen and designed by legendary American aeronautical engineer and visionary Burt Rutan—to take paying passengers into suborbital space. Virgin Galactic (wholly owned by Virgin Group) plans to make flights available to the public with tickets priced at US$200,000 using Scaled Composites White Knight Two.[23] Branson plans to take his two children, 31-year-old Holly and 28-year-old Sam, on a trip to outer space when they ride the SpaceShipTwo rocket plane on its first public flight planned for 2014.[24]

Branson's next venture with the Virgin group is Virgin Fuels, which is set to respond to global warming and exploit the recent spike in fuel costs by offering a revolutionary, cheaper fuel for automobiles and, in the near future, aircraft. Branson has stated that he was formerly a global warming sceptic and was influenced in his decision by a breakfast meeting with Al Gore.[25]

On 21 September 2006, Branson pledged to invest the profits of Virgin Atlantic and Virgin Trains in research for environmentally friendly fuels. The investment is estimated to be worth $3 billion.[26][27]

On 4 July 2006, Branson sold his Virgin Mobile company to UK cable TV, broadband, and telephone company NTL/NTL:Telewest for almost £1 billion. A new company was launched with much fanfare and publicity on 8 February 2007, under the name Virgin Media. The decision to merge his Virgin Media Company with NTL was to integrate both of the companies' compatible parts of commerce. Branson used to own three-quarters of Virgin Mobile, whereas now he owns 15 percent of the new Virgin Media company.[28]

In 2006, Branson formed Virgin Comics and Virgin Animation, an entertainment company focused on creating new stories and characters for a global audience. The company was founded with author Deepak Chopra, filmmaker Shekhar Kapur, and entrepreneurs Sharad Devarajan and Gotham Chopra. Branson also launched the Virgin Health Bank on 1 February 2007, offering parents-to-be the opportunity to store their baby's umbilical cord blood stem cells in private and public stem-cell banks.

In June 2006, a tip-off from Virgin Atlantic led US and UK competition authorities to investigate price-fixing attempts between Virgin Atlantic and British Airways. In August 2007, British Airways was fined £271 million over the allegations. Virgin Atlantic was given immunity for tipping off the authorities and received no fine—a controversial decision the Office of Fair Trading defended as being in the public interest.[29]

On 9 February 2007, Branson announced the setting up of a new global science and technology prize—The Virgin Earth Challenge—in the belief that history has shown that prizes of this nature encourage technological advancements for the good of mankind. The Virgin Earth Challenge will award $25 million to the individual or group who are able to demonstrate a commercially viable design that will result in the net removal of anthropogenic, atmospheric greenhouse gases each year for at least ten years without countervailing harmful effects. This removal must have long-term effects and contribute materially to the stability of the Earth's climate. Branson also announced that he would be joined in the adjudication of the prize by a panel of five judges, all world authorities in their respective fields: Al Gore, Sir Crispin Tickell, Tim Flannery, James E. Hansen, and James Lovelock.

In July 2007, Branson purchased his Australian home, Makepeace Island, in Noosa.[30] In August 2007, Branson announced that he bought a 20-percent stake in Malaysia's AirAsia X.[31]

Branson in April 2009 at the launch of Virgin America in Orange County, California.

On 13 October 2007, Branson's Virgin Group sought to add Northern Rock to its empire after submitting an offer that would result in Branson personally owning 30% of the company and change the company's name from Northern Rock to Virgin Money.[32] The Daily Mail ran a campaign against his bid and Vince Cable, financial spokesperson for Liberal Democrats', suggested in the House of Commons that Branson's criminal conviction for tax evasion might be felt by some as a good enough reason not to trust him with public money.[33]

On 10 January 2008, Branson's Virgin Healthcare announced that it would open a chain of health care clinics that would offer conventional medical care alongside homoeopathic and complementary therapies, a development that was welcomed by Ben Bradshaw, the UK's health minister.[34]

Plans where GPs could be paid for referring National Health Service (NHS) patients to private Virgin services were abandoned in June 2008. The BMA warned the plan would "damage clinical objectivity", there would be a financial incentive for GPs to push patients toward the Virgin services at the centre.[35] Plans to take over an NHS Practice in Swindon were abandoned subsequently, in late September 2008.[36]

In February 2009, Branson's Virgin organisation were reported as bidding to buy the former Honda Formula One team. Branson later stated an interest in Formula One, but claimed that, before the Virgin brand became involved with Honda or any other team, Formula One would have to develop a more economically efficient and environmentally responsible image. At the start of the 2009 formula one season on 28 March, it was announced that Virgin would be sponsoring the new Brawn GP team,[37] with discussions also under way about introducing a less "dirty" fuel in the medium term.[38] After the end of the season and the subsequent purchase of Brawn GP by Mercedes Benz, Branson invested in an 80% buyout of Manor Grand Prix,[39][40] with the team being renamed Virgin Racing.

Branson and Tony Fernandes, owner of Air Asia and Lotus F1 Racing, had a bet for the 2010 F1 season where the team's boss should work on the winner's airline during a charity flight dressed as a stewardess. Fernandes escaped as the winner of the bet, as Lotus Racing ended tenth in the championship, while Virgin Racing ended twelfth and last. Branson kept his word after losing the bet, as he served his duty as a stewardess on an Air Asia flight between Perth and Kuala Lumpur on 12 May 2013.[41]

In 2010, Branson became patron of the UK's Gordon Bennett 2010 gas balloon race, which has 16 hydrogen balloons flying across Europe.[42]

In April 2010, Branson described the closure of large parts of European airspace owing to volcanic ash as "beyond a joke". Some scientists later concluded that serious structural damage to aircraft could have occurred if passenger planes had continued to fly.[43]

In July 2012, Branson announced plans to build an orbital space launch system, designated LauncherOne.[44] Four commercial customers have already contracted for launches and two companies are developing standardised satellite buses optimised to the design of LauncherOne, in expectation of business opportunities created by the new smallsat launcher.[45]

In August 2012, the franchise for the West Coast Main Line, managed by Virgin Rail since 1997, came to an end. The contract was awarded to FirstGroup after a competitive tender process overseen by the Department for Transport. Branson had expressed his concerns about the tender process and questioned the validity of the business plan submitted by FirstGroup. When Virgin Rail lost the contract, Branson said he was convinced the civil servants had "got their maths wrong". In October, after an investigation into the bidding process, the deal was scrapped. The Transport Secretary announced there were "significant technical flaws" in the process and mistakes had been made by transport staff. Virgin Rail continue to operate the West Coast line.[46]

World record attempts


A 1998 attempt at an around-the-world balloon flight by Branson, Fossett, and Lindstrand ends in the Pacific Ocean on 25 December 1998.

Branson made several world record-breaking attempts after 1985, when in the spirit of the Blue Riband he attempted the fastest Atlantic Ocean crossing. His first attempt in the "Virgin Atlantic Challenger" led to the boat capsizing in British waters and a rescue by RAF helicopter, which received wide media coverage. Some newspapers called for Branson to reimburse the government for the rescue cost. In 1986, in his "Virgin Atlantic Challenger II", with sailing expert Daniel McCarthy, he beat the record by two hours.[5] A year later his hot air balloon "Virgin Atlantic Flyer" crossed the Atlantic.[47]

In January 1991, Branson crossed the Pacific from Japan to Arctic Canada, 6,700 miles (10,800 km), in a balloon of 2,600,000 cubic feet (74,000 m3). This broke the record, with a speed of 245 miles per hour (394 km/h).

Between 1995 and 1998 Branson, Per Lindstrand and Steve Fossett made attempts to circumnavigate the globe by balloon. In late 1998 they made a record-breaking flight from Morocco to Hawaii but were unable to complete a global flight before Bertrand Piccard and Brian Jones in Breitling Orbiter 3 in March 1999.

In March 2004, Branson set a record by travelling from Dover to Calais in a Gibbs Aquada in 1 hour, 40 minutes and 6 seconds, the fastest crossing of the English Channel in an amphibious vehicle. The previous record of six hours was set by two Frenchmen.[48] The cast of Top Gear, Jeremy Clarkson, James May and Richard Hammond, attempted to break this record in an amphibious vehicle which they had constructed and, while successfully crossing the channel, did not break Branson's record. After being intercepted by the Coast Guard and asked what their intentions were, Clarkson remarked "..our intentions are to go across the Channel faster than 'Beardy' Branson!". The Coast Guard wished them good luck and left.[49]

In September 2008, Branson and his children made an unsuccessful attempt at an Eastbound record crossing of the Atlantic ocean under sail in the 99 feet (30 m) sloop Virgin Money.[50] The boat, also known as Speedboat, is owned by NYYC member Alex Jackson, who was a co-skipper on this passage, with Branson and Mike Sanderson. After 2 days, 4 hours, winds of force 7 to 9 (strong gale), and seas of 40 feet (12 m), a 'monster wave' destroyed the spinnaker, washed a ten-man life raft overboard and severely ripped the mainsail. She eventually continued to St. George's, Bermuda.[51]

Television, film and print


Branson has guest starred, usually playing himself, on several television shows, including Friends, Baywatch, Birds of a Feather, Only Fools and Horses, The Day Today, a special episode of the comedy Goodness Gracious Me and Tripping Over. Branson made several appearances during the nineties on the BBC Saturday morning show Live & Kicking, where he was referred to as 'the pickle man' by comedy act Trev and Simon (in reference to Branston Pickle).[52] Branson also appears in a cameo early in XTC's "Generals and Majors" video. He was also the star of a reality television show on Fox called The Rebel Billionaire: Branson's Quest for the Best (2004), in which sixteen contestants were tested for their entrepreneurship and sense of adventure. It did not succeed as a rival show to Donald Trump's The Apprentice and only lasted one season.

His high public profile often leaves him open as a figure of satire—the 2000 AD series Zenith features a parody of Branson as a super villain, as the comic's publisher and favoured distributor and the Virgin group were in competition at the time. He is also caricatured in The Simpsons episode "Monty Can't Buy Me Love" as the tycoon Arthur Fortune, and as the ballooning megalomaniac Richard Chutney (a pun on Branson, as in Branston Pickle) in Believe Nothing. The character Grandson Richard 39 in Terry Pratchett's Wings is modelled on Branson.

He has a cameo appearance in several films: Around the World in 80 Days (2004), where he played a hot-air balloon operator; Superman Returns, where he was credited as a 'Shuttle Engineer' and appeared alongside his son, Sam, with a Virgin Galactic-style commercial suborbital shuttle at the centre of his storyline. He also has a cameo in the James Bond film Casino Royale. Here, he is seen as a passenger going through Miami Airport security check-in and being frisked – several Virgin Atlantic planes appear soon after. British Airways edited out Branson's cameo in their in-flight screening of the movie.[53] He makes a number of brief and disjointed appearances in the cult classic documentary Derek and Clive Get the Horn which follows the exploits of Peter Cook and Dudley Moore recording their last comedy album. Branson and his mother were also featured in the documentary film, Lemonade Stories. In early 2006 on Rove Live, Rove McManus and Sir Richard pushed each other into a swimming pool fully clothed live on TV during a "Live at your house" episode.

Branson is a Star Trek fan and named his new spaceship VSS Enterprise in honour of the famous Star Trek ships, and in 2006, reportedly offered actor William Shatner a ride on the inaugural space launch of Virgin Galactic. In an interview in Time magazine, 10 August 2009, Shatner claimed that Branson approached him asking how much he would pay for a ride on the spaceship. In response, Shatner asked "how much would you pay me to do it?"

In August 2007, Branson announced on The Colbert Report that he had named a new aircraft Air Colbert. He later doused political satirist and talk show host Stephen Colbert with water from his mug. Branson subsequently took a retaliatory splash from Colbert. The interview quickly ended, with both laughing[54] as shown on the episode aired on Comedy Central on 22 August 2007. The interview was promoted on The Report as the Colbert-Branson Interview Trainwreck. Branson then made a cameo appearance on The Soup playing an intern working under Joel McHale who had been warned against getting into water fights with Stephen Colbert, and being subsequently fired.

In March 2008 he launched Virgin Mobile in India and during that period, he even played a cameo performance in Bollywood film, London Dreams.[55] In July 2010, Branson narrated Australian sailor Jessica Watson's documentary about her solo sailing trip around the world. It premiered on ONEHD on 16 August 2010.[citation needed]

In April 2011 Branson appeared on CNN's Mainsail[56] with Kate Winslet. Together they re-enacted a famous scene[57] from the 1997 film Titanic for the cameras. On 17 August 2011, he was featured in the premier episode of Hulu's first long-form original production entitled, A Day in the Life.[58]

At the 2012 Pride of Britain Awards broadcast on ITV on 30 October, Branson, along with Michael Caine, Elton John, Simon Cowell and Stephen Fry, recited Rudyard Kipling's poem If— in tribute to the 2012 British Olympic and Paralympics heroes.[59]

Humanitarian initiatives

In the late 1990s, Branson and musician Peter Gabriel discussed with Nelson Mandela their idea of a small, dedicated group of leaders, working objectively and without any vested personal interest to solve difficult global conflicts.[60] On 18 July 2007, in Johannesburg, South Africa, Mandela announced the formation of a new group, The Elders, in a speech he delivered on his 89th birthday. Kofi Annan serves as Chair of The Elders and Gro Harlem Brundtland as Deputy Chair. The other members are Martti Ahtisaari, Ela Bhatt, Lakhdar Brahimi, Fernando Henrique Cardoso, Jimmy Carter, Hina Jilani, Graça Machel, Mary Robinson and Ernesto Zedillo. Desmond Tutu and Mandela have been Honorary Elders. The Elders is independently funded by a group of donors, including Branson and Gabriel. The Elders use their collective skills to catalyse peaceful resolutions to long-standing conflicts, articulate new approaches to global issues that are causing or may cause immense human suffering, and share wisdom by helping to connect voices all over the world.

Richard Branson with his mother Eve, and the Board of Directors of the International Centre for Missing & Exploited Children

In 1999, Branson became a founding sponsor of the International Centre for Missing & Exploited Children ("ICMEC"), the goal of which is to help find missing children, and to stop the exploitation of children, as his mother Eve became a founding member of ICMEC's Board of Directors.[61][62]

Branson's other work in South Africa includes the Branson School of Entrepreneurship, set up in 2005 as a partnership between Virgin Unite, the non-profit foundation of Virgin, and entrepreneur Taddy Blecher, the founder of CIDA City Campus, a university in Johannesburg. The school aims to improve economic growth in South Africa by supporting start-ups and micro-enterprises with skills, mentors, services, networks and finance arrangements.[63][64] Fundraising activity to support the school is achieved by the Sunday Times Fast Track 100, sponsored by Virgin Group, at its yearly event, where places to join Richard Branson on trips to South Africa to provide coaching and mentoring to students are auctioned to attendees. In 2009, Jason Luckhurst and Boyd Kershaw of Practicus, Martin Ainscough of the Ainscough Group and Matthew Riley of Daisy Communications helped raise £150,000 through the auction.[65]

In March 2008, Branson hosted an environmental gathering at his private island, Necker Island, in the Caribbean with several prominent entrepreneurs, celebrities, and world leaders. They discussed global warming-related problems facing the world, hoping that the meeting would be a precursor to future discussions regarding similar problems. Former British Prime Minister Tony Blair, Wikipedia co-founder Jimmy Wales, and Larry Page of Google were in attendance.[66]

On 8 May 2009, Branson took over Mia Farrow's hunger strike for three days in protest of the Sudanese government expulsion of aid groups from the Darfur region.[67] In 2010, he and the Nduna Foundation (founded by Amy Robbins), and Humanity United (an organization backed by Pam Omidyar, the wife of eBay founder Pierre Omidyar) founded Enterprise Zimbabwe.[68]

Branson is a signatory of Global Zero (campaign), a non-profit international initiative for the elimination of all nuclear weapons worldwide.[69] Since its launch in Paris in December 2008,[70] Global Zero (campaign) has grown to 300 leaders, including current and former heads of state, national security officials and military commanders, and 400,000 citizens worldwide; developed a practical step-by-step plan to eliminate nuclear weapons; launched an international student campaign with 75 campus chapters in eight countries; and produced an acclaimed documentary film, Countdown to Zero, in partnership with Lawrence Bender and Participant Media.[71]

Since 2010, Branson has served as a Commissioner on the Broadband Commission for Digital Development, a UN initiative which promotes universal access to broadband services.[72] In 2011, Branson served on the Global Commission on Drug Policy with former political and cultural leaders of Latin America and elsewhere, "in a bid to boost the effort to achieve more humane and rational drug laws."[73]

In December 2013 Branson urged companies to boycott Uganda because of its "anti-homosexuality bill." Branson stated that it would be "against my conscience to support this country...governments must realize that people should be able to love whoever they want."[74]

In 2014, Branson joined forces with African Wildlife Foundation and partner WildAid for the "Say No" Campaign,[75] an initiative to bring public awareness to the issues of wildlife poaching and trafficking.

Politics

In the 1980s, Branson was briefly given the post of "litter Tsar" by Margaret Thatcher—charged with "keeping Britain tidy".[76][77] In 2005 he declared that there were only negligible differences between the two main parties on economic matters.[78] He has frequently been mentioned as a candidate for Mayor of London, and polls have suggested he would be a viable candidate, though he has yet to express interest.[79][80][81] He supports continuing British membership of the European Union and opposes having a referendum on the issue.[82]

Controversies and criticism

Tax

Branson's business empire is owned by a complicated series of offshore trusts and companies. The Sunday Times stated that his wealth is calculated at £3 billion; if he were to retire to his Caribbean island and liquidate all of this, he would pay relatively little in tax.[83] Branson has been criticised for his business strategy, and has been accused of being a carpetbagger.[84][85][86][87] Branson responded that he is living on Necker for health rather than tax reasons.[88]

Profiting from SeaWorld

Branson has been criticized by the Whale and Dolphin Conservation organization for profiting from selling trips to SeaWorld and similar themed parks that hold dolphins, whales and other sea life in captivity for entertainment purposes.[89][90]

Honours and awards


Branson at a conference in San Diego, California, on 8 July 2013.

In 1993, Branson was awarded an honorary degree of Doctor of Technology from Loughborough University.

In the New Years Honours list dated 30 December 1999, Elizabeth II signified her intention to confer the honour of Knight Bachelor on him for his "services to entrepreneurship".[91][92] He was knighted by Charles, Prince of Wales on 30 March 2000 at an investiture in Buckingham Palace.[93]

Also in 2000, Branson received the 'Tony Jannus Award' for his accomplishments in commercial air transportation.

Branson appears at No. 85 on the 2002 list of "100 Greatest Britons" (sponsored by the BBC and voted for by the public). Branson was also ranked in 2007's Time Magazine "Top 100 Most Influential People in the World". In 2009, Branson was voted the UK's "Celebrity Dream Boss" in an opinion poll by Cancer Research UK.[94]

On 7 December 2007, United Nations Secretary General Ban Ki-Moon presented Branson with the United Nations Correspondents Association Citizen of the World Award for his support for environmental and humanitarian causes.[95]

On 24 January 2011, Branson was awarded the German Media Prize (organised by "Media Control Charts"), previously handed to former US president Bill Clinton and the Dalai Lama.

On 14 November 2011, Branson was awarded the ISTA Prize by the International Space Transport Association in The Hague for his pioneering achievements in the development of suborbital transport systems with "Virgin Galactic".[96]

On 11 February 2012, Branson was honoured with the National Academy of Recording Arts and Sciences' President's Merit Award for his contributions to the music industry. The event took place the night before the 54th Grammy Awards.[97]

On 2 June 2013, Branson received an honorary degree of Doctor Honoris Causa from Kaunas Technology University in Kaunas, Lithuania.[98]

On 15 May 2014, Branson received the 2014 Business for Peace Award, awarded annually by the Business for Peace Foundation in Oslo, Norway.[99]

On 21 September 2014, Branson was recognized by The Sunday Times as the most admired business person over the last five decades.[100]

On 9 October 2014, Branson was named as the number one LGBT ally in the Outstanding allies rankings. [101]

Personal life

Branson has a daughter named Holly and a son named Sam. He stated in an interview with Piers Morgan that he and his wife Joan had a daughter named Clare Sarah who died when she was just four days old in 1979.[102] The couple wed—at their daughter Holly's suggestion when she was eight years old—in 1989 at Necker Island, a 74-acre (30 ha) island owned by Branson in the British Virgin Islands.[103]

In 1998, Branson released his autobiography, titled Losing My Virginity, an international best-seller.[104]

Branson was deeply saddened by the disappearance of fellow adventurer Steve Fossett in September 2007; the following month he wrote an article for Time magazine, titled "My Friend, Steve Fossett".[105]

Influences

Branson has stated in a number of interviews that he derives much influence from non-fiction books. He most commonly names Nelson Mandela's autobiography, Long Walk to Freedom, explaining that Mandela was "one of the most inspiring men I have ever met and had the honour to call my friend."
Owing to his interest in humanitarian and ecological issues, Branson also lists Al Gore's best-selling book, An Inconvenient Truth, and The Revenge of Gaia by James Lovelock amongst his favourites. According to Branson's book, Screw It, Let's do It. Lessons in Life, he is also a huge fan of works by Jung Chang.[106] In terms of fiction, Branson has long held an admiration for the fictional character Peter Pan,[107] and in 2006 he founded Virgin Comics LLC, stating that Virgin Comics will give "a whole generation of young, creative thinkers a voice."[108]

Bayesian inference

From Wikipedia, the free encyclopedia https://en.wikipedia.org/wiki/Bayesian_inference Bayesian inference ( / ...