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Sunday, October 26, 2025

Senescence

From Wikipedia, the free encyclopedia

Senescence (/ˌsɪˈnɛsəns/) or biological aging is the gradual deterioration of functional characteristics in living organisms. Whole organism senescence involves an increase in death rates or a decrease in fecundity with increasing age, at least in the later part of an organism's life cycle. However, the effects of senescence can be delayed. The 1934 discovery that calorie restriction can extend lifespans by 50% in rats, the existence of species having negligible senescence, and the existence of potentially immortal organisms such as members of the genus Hydra have motivated research into delaying senescence and thus age-related diseases. Rare human mutations can cause accelerated aging diseases.

Environmental factors may affect aging – for example, overexposure to ultraviolet radiation accelerates skin aging. Different parts of the body may age at different rates and distinctly, including the brain, the cardiovascular system, and muscle. Similarly, functions may distinctly decline with aging, including movement control and memory. Two organisms of the same species can also age at different rates, making biological aging and chronological aging distinct concepts.

Definition and characteristics

Organismal senescence is the aging of whole organisms. Actuarial senescence can be defined as an increase in mortality or a decrease in fecundity with age. The Gompertz–Makeham law of mortality says that the age-dependent component of the mortality rate increases exponentially with age.

Aging is characterized by the declining ability to respond to stress, increased homeostatic imbalance, and increased risk of aging-associated diseases, including cancer and heart disease. Aging has been defined as "a progressive deterioration of physiological function, an intrinsic age-related process of loss of viability and increase in vulnerability."

In 2013, a group of scientists defined nine hallmarks of aging that are common between organisms with emphasis on mammals:

In a decadal update, three hallmarks have been added, totaling 12 proposed hallmarks:

The environment induces damage at various levels, e.g., damage to DNA, and damage to tissues and cells by oxygen radicals (widely known as free radicals), and some of this damage is not repaired and thus accumulates with time. Cloning from somatic cells rather than germ cells may begin life with a higher initial load of damage. Dolly the sheep died young from a contagious lung disease, but data on an entire population of cloned individuals would be necessary to measure mortality rates and quantify aging.

The evolutionary theorist George Williams wrote, "It is remarkable that after a seemingly miraculous feat of morphogenesis, a complex metazoan should be unable to perform the much simpler task of merely maintaining what is already formed."

Variation among species

Different speeds with which mortality increases with age correspond to different maximum life span among species. For example, a mouse is elderly at 3 years, a human is elderly at 80 years, and ginkgo trees show little effect of age even at 667 years.

Almost all organisms senesce, including bacteria which have asymmetries between "mother" and "daughter" cells upon cell division, with the mother cell experiencing aging, while the daughter is rejuvenated. There is negligible senescence in some groups, such as the genus HydraPlanarian flatworms have "apparently limitless telomere regenerative capacity fueled by a population of highly proliferative adult stem cells." These planarians are not biologically immortal, but rather their death rate slowly increases with age. Organisms that are thought to be biologically immortal would, in one instance, be Turritopsis dohrnii, also known as the "immortal jellyfish", due to its ability to revert to its youth when it undergoes stress during adulthood. The reproductive system is observed to remain intact, and even the gonads of Turritopsis dohrnii exist.

Some species exhibit "negative senescence", in which reproduction capability increases or is stable, and mortality falls with age, resulting from the advantages of increased body size during aging.

Theories of aging

Unsolved problem in biology
Why does biological aging occur?

More than 300 different theories have been posited to explain the nature (mechanisms) and causes (reasons for natural emergence or factors) of aging. Good theories would both explain past observations and predict the results of future experiments. Some of the theories may complement each other, overlap, contradict, or may not preclude various other theories.

Theories of aging fall into two broad categories: evolutionary theories of aging and mechanistic theories of aging. Evolutionary theories of aging primarily explain why aging happens, but do not concern themselves with the molecular mechanism(s) that drive the process. All evolutionary theories of aging rest on the basic mechanisms that the force of natural selection declines with age. Mechanistic theories of aging can be divided into theories that propose aging is programmed, and damage accumulation theories, i.e. those that propose aging to be caused by specific molecular changes occurring over time.

The aging process can be explained with different theories. These are evolutionary theories, molecular theories, system theories and cellular theories. The evolutionary theory of ageing was first proposed in the late 1940s and can be explained briefly by the accumulation of mutations (evolution of ageing), disposable soma and antagonistic pleiotropy hypothesis. The molecular theories of ageing include phenomena such as gene regulation (gene expression), codon restriction, error catastrophe, somatic mutation, accumulation of genetic material (DNA) damage (DNA damage theory of aging) and dysdifferentiation. The system theories include the immunologic approach to ageing, rate-of-living and the alterations in neuroendocrinal control mechanisms. (See homeostasis). Cellular theory of ageing can be categorized as telomere theory, free radical theory (free-radical theory of aging) and apoptosis. The stem cell theory of aging is also a sub-category of cellular theories.

Evolutionary aging theories

Antagonistic pleiotropy

One theory was proposed by George C. Williams and involves antagonistic pleiotropy. A single gene may affect multiple traits. Some traits that increase fitness early in life may also have negative effects later in life. But, because many more individuals are alive at young ages than at old ages, even small positive effects early can be strongly selected for, and large negative effects later may be very weakly selected against. Williams suggested the following example: Perhaps a gene codes for calcium deposition in bones, which promotes juvenile survival and will therefore be favored by natural selection; however, this same gene promotes calcium deposition in the arteries, causing negative atherosclerotic effects in old age. Thus, harmful biological changes in old age may result from selection for pleiotropic genes that are beneficial early in life but harmful later on. In this case, selection pressure is relatively high when Fisher's reproductive value is high and relatively low when Fisher's reproductive value is low.

Cancer versus cellular senescence tradeoff theory of aging

Senescent cells within a multicellular organism can be purged by competition between cells, but this increases the risk of cancer. This leads to an inescapable dilemma between two possibilities—the accumulation of physiologically useless senescent cells and cancer, both of which lead to increasing rates of mortality with age.

Disposable soma

The disposable soma theory of aging was proposed by Thomas Kirkwood in 1977. The theory suggests that aging occurs due to a strategy in which an individual only invests in maintenance of the soma for as long as it has a realistic chance of survival. A species that uses resources more efficiently will live longer, and therefore be able to pass on genetic information to the next generation. The demands of reproduction are high, so less effort is invested in the repair and maintenance of somatic cells, compared to germline cells, to focus on reproduction and species survival.

Programmed aging theories

Programmed theories of aging posit that aging is adaptive, normally invoking selection for evolvability or group selection.

The reproductive-cell cycle theory suggests that aging is regulated by changes in hormonal signaling over the lifespan.

Damage accumulation theories

The free radical theory of aging

One of the most prominent theories of aging was first proposed by Harman in 1956. It posits that free radicals produced by dissolved oxygen, radiation, cellular respiration, and other sources cause damage to the molecular machines in the cell and gradually wear them down. This is also known as oxidative stress.

There is substantial evidence to back up this theory. Old animals have larger amounts of oxidized proteins, DNA, and lipids than their younger counterparts.

Chemical damage

Elderly Klamath woman photographed by Edward S. Curtis in 1924

One of the earliest aging theories was the Rate of Living Hypothesis described by Raymond Pearl in 1928 (based on earlier work by Max Rubner), which states that fast basal metabolic rate corresponds to short maximum life span.

While there may be some validity to the idea that for various types of specific damage detailed below that are by-products of metabolism, all other things being equal, a fast metabolism may reduce lifespan, in general this theory does not adequately explain the differences in lifespan either within, or between, species. Calorically restricted animals process as much, or more, calories per gram of body mass, as their ad libitum fed counterparts, yet exhibit substantially longer lifespans. Similarly, metabolic rate is a poor predictor of lifespan for birds, bats and other species that, it is presumed, have reduced mortality from predation, and therefore have evolved long lifespans even in the presence of very high metabolic rates. In a 2007 analysis it was shown that, when modern statistical methods for correcting for the effects of body size and phylogeny are employed, metabolic rate does not correlate with longevity in mammals or birds.

Concerning specific types of chemical damage caused by metabolism, it is suggested that damage to long-lived biopolymers, such as structural proteins or DNA, caused by ubiquitous chemical agents in the body such as oxygen and sugars, are in part responsible for aging. The damage can include breakage of biopolymer chains, cross-linking of biopolymers, or chemical attachment of unnatural substituents (haptens) to biopolymers. Under normal aerobic conditions, approximately 4% of the oxygen metabolized by mitochondria is converted to superoxide ion, which can subsequently be converted to hydrogen peroxide, hydroxyl radical and eventually other reactive species including other peroxides and singlet oxygen, which can, in turn, generate free radicals capable of damaging structural proteins and DNA. Certain metal ions found in the body, such as copper and iron, may participate in the process. (In Wilson's disease, a hereditary defect that causes the body to retain copper, some of the symptoms resemble accelerated senescence.) These processes termed oxidative stress are linked to the potential benefits of dietary polyphenol antioxidants, for example in coffee, and tea. However their typically positive effects on lifespans when consumption is moderate have also been explained by effects on autophagyglucose metabolism and AMPK.

Sugars such as glucose and fructose can react with certain amino acids such as lysine and arginine and certain DNA bases such as guanine to produce sugar adducts, in a process called glycation. These adducts can further rearrange to form reactive species, which can then cross-link the structural proteins or DNA to similar biopolymers or other biomolecules such as non-structural proteins. People with diabetes, who have elevated blood sugar, develop senescence-associated disorders much earlier than the general population, but can delay such disorders by rigorous control of their blood sugar levels. There is evidence that sugar damage is linked to oxidant damage in a process termed glycoxidation.

Free radicals can damage proteins, lipids or DNA. Glycation mainly damages proteins. Damaged proteins and lipids accumulate in lysosomes as lipofuscin. Chemical damage to structural proteins can lead to loss of function; for example, damage to collagen of blood vessel walls can lead to vessel-wall stiffness and, thus, hypertension, and vessel wall thickening and reactive tissue formation (atherosclerosis); similar processes in the kidney can lead to kidney failure. Damage to enzymes reduces cellular functionality. Lipid peroxidation of the inner mitochondrial membrane reduces the electric potential and the ability to generate energy. It is probably no accident that nearly all of the so-called "accelerated aging diseases" are due to defective DNA repair enzymes.

It is believed that the impact of alcohol on aging can be partly explained by alcohol's activation of the HPA axis, which stimulates glucocorticoid secretion, long-term exposure to which produces symptoms of aging.

DNA damage

DNA damage was proposed in a 2021 review to be the underlying cause of aging because of the mechanistic link of DNA damage to nearly every aspect of the aging phenotype. Slower rate of accumulation of DNA damage as measured by the DNA damage marker gamma H2AX in leukocytes was found to correlate with longer lifespans in comparisons of dolphins, goats, reindeer, American flamingos and griffon vultures. DNA damage-induced epigenetic alterations, such as DNA methylation and many histone modifications, appear to be of particular importance to the aging process. Evidence for the theory that DNA damage is the fundamental cause of aging was first reviewed in 1981.

Mutation accumulation

Natural selection can support lethal and harmful alleles, if their effects are felt after reproduction. The geneticist J. B. S. Haldane wondered why the dominant mutation that causes Huntington's disease remained in the population, and why natural selection had not eliminated it. The onset of this neurological disease is (on average) at age 45 and is invariably fatal within 10–20 years. Haldane assumed that, in human prehistory, few survived until age 45. Since few were alive at older ages and their contribution to the next generation was therefore small relative to the large cohorts of younger age groups, the force of selection against such late-acting deleterious mutations was correspondingly small. Therefore, a genetic load of late-acting deleterious mutations could be substantial at mutation–selection balance. This concept came to be known as the selection shadow.

Peter Medawar formalised this observation in his mutation accumulation theory of aging. "The force of natural selection weakens with increasing age—even in a theoretically immortal population, provided only that it is exposed to real hazards of mortality. If a genetic disaster... happens late enough in individual life, its consequences may be completely unimportant". Age-independent hazards such as predation, disease, and accidents, called 'extrinsic mortality', mean that even a population with negligible senescence will have fewer individuals alive in older age groups.

Other damage

A study concluded that retroviruses in the human genomes can become awakened from dormant states and contribute to aging which can be blocked by neutralizing antibodies, alleviating "cellular senescence and tissue degeneration and, to some extent, organismal aging".

Stem cell theories of aging

The stem cell theory of aging postulates that the aging process is the result of the inability of various types of stem cells to continue to replenish the tissues of an organism with functional differentiated cells capable of maintaining that tissue's (or organ's) original function. Damage and error accumulation in genetic material is always a problem for systems regardless of the age. The number of stem cells in young people is very much higher than older people and thus creates a better and more efficient replacement mechanism in the young contrary to the old. In other words, aging is not a matter of the increase in damage, but a matter of failure to replace it due to a decreased number of stem cells. Stem cells decrease in number and tend to lose the ability to differentiate into progenies or lymphoid lineages and myeloid lineages.

Maintaining the dynamic balance of stem cell pools requires several conditions. Balancing proliferation and quiescence along with homing (See niche) and self-renewal of hematopoietic stem cells are favoring elements of stem cell pool maintenance while differentiation, mobilization and senescence are detrimental elements. These detrimental effects will eventually cause apoptosis.

There are also several challenges when it comes to therapeutic use of stem cells and their ability to replenish organs and tissues. First, different cells may have different lifespans even though they originate from the same stem cells (See T-cells and erythrocytes), meaning that aging can occur differently in cells that have longer lifespans as opposed to the ones with shorter lifespans. Also, continual effort to replace the somatic cells may cause exhaustion of stem cells.
Hematopoietic stem cell aging
Hematopoietic stem cells (HSCs) regenerate the blood system throughout life and maintain homeostasis. DNA strand breaks accumulate in long term HSCs during aging. This accumulation is associated with a broad attenuation of DNA repair and response pathways that depends on HSC quiescence. DNA ligase 4 (Lig4) has a highly specific role in the repair of double-strand breaks by non-homologous end joining (NHEJ). Lig4 deficiency in the mouse causes a progressive loss of HSCs during aging. These findings suggest that NHEJ is a key determinant of the ability of HSCs to maintain themselves over time.
Hematopoietic stem cell diversity aging
A study showed that the clonal diversity of stem cells that produce blood cells gets drastically reduced around age 70 to a faster-growing few, substantiating a novel theory of ageing which could enable healthy aging.
Hematopoietic mosaic loss of chromosome Y
A 2022 study showed that blood cells' loss of the Y chromosome in a subset of cells, called 'mosaic loss of chromosome Y' (mLOY) and reportedly affecting at least 40% of 70 years-old men to some degree, contributes to fibrosis, heart risks, and mortality in a causal way.

Biomarkers of aging

If different individuals age at different rates, then fecundity, mortality, and functional capacity might be better predicted by biomarkers than by chronological age. However, graying of hairface aging, skin wrinkles, and other common changes seen with aging are not better indicators of future functionality than chronological age. Biogerontologists have continued efforts to find and validate biomarkers of aging, but success thus far has been limited.

Levels of CD4 and CD8 memory T cells and naive T cells have been used to give good predictions of the expected lifespan of middle-aged mice.

Aging clocks

There is increasing interest in epigenetic clocks as biomarkers of aging, based on their ability to predict human chronological age. Many epigenetic aging clocks are based on DNA methylation , but alternative epigenetic clocks are also starting to emerge, e.g. based on nucleosome positioning derived from cell-free DNA. Basic blood biochemistry and cell counts can also be used to accurately predict the chronological age. It is also possible to predict the human chronological age using transcriptomic aging clocks.

There is research and development of further biomarkers, detection systems, and software systems to measure the biological age of different tissues or systems or overall. For example, a deep learning (DL) software using anatomic magnetic resonance images estimated brain age with relatively high accuracy, including detecting early signs of Alzheimer's disease and varying neuroanatomical patterns of neurological aging, and a DL tool was reported as to calculate a person's inflammatory age based on patterns of systemic age-related inflammation.

Aging clocks have been used to evaluate the impacts of interventions on humans, including combination therapies. Employing aging clocks to identify and evaluate longevity interventions represents a fundamental goal in aging biology research. However, achieving this goal requires overcoming numerous challenges and implementing additional validation steps.

Genetic determinants of aging

Several genetic components of aging have been identified using model organisms, ranging from the simple budding yeast Saccharomyces cerevisiae to worms such as Caenorhabditis elegans and fruit flies (Drosophila melanogaster). Study of these organisms has revealed the presence of at least two conserved aging pathways.

Gene expression is imperfectly controlled, and random fluctuations in the expression levels of many genes may contribute to the aging process, as suggested by a study of such genes in yeast. Individual cells, which are genetically identical, nonetheless can have substantially different responses to outside stimuli, and markedly different lifespans, indicating the epigenetic factors play an important role in gene expression and aging as well as genetic factors. There is research into epigenetics of aging.

The ability to repair DNA double-strand breaks declines with aging in mice and humans.

A set of rare hereditary (genetics) disorders, each called progeria, has been known for some time. Sufferers exhibit symptoms resembling accelerated aging, including wrinkled skin. The cause of Hutchinson–Gilford progeria syndrome was reported in the journal Nature in May 2003. This report suggests that DNA damage, not oxidative stress, is the cause of this form of accelerated aging.

A study indicates that aging may shift activity toward short genes or shorter transcript length and that this can be countered by interventions.

Healthspans and aging in society

Past and projected age of the human world population through time as of 2021
Healthspan-lifespan gap (LHG)
Healthspan extension relies on the unison of social, clinical and scientific programs or domains of work.

Healthspan can broadly be defined as the period of one's life that one is healthy, such as being free of significant diseases or declines of capacities (e.g., senses such as hearing, muscle, endurance and cognition).

With aging populations, there is a rise of age-related diseases which puts major burdens on healthcare systems as well as contemporary economies or contemporary economics and their appendant societal systems. Healthspan extension and anti-aging research seek to extend the span of health in the old as well as slow aging or its negative impacts such as physical and mental decline. Modern anti-senescent and regenerative technology with augmented decision making could help "responsibly bridge the healthspan-lifespan gap for a future of equitable global wellbeing". Aging is "the most prevalent risk factor for chronic disease, frailty and disability, and it is estimated that there will be over 2 billion persons age > 60 by the year 2050", making it a large global health challenge that demands substantial (and well-orchestrated or efficient) efforts, including interventions that alter and target the inborn aging process.

Biological aging or the LHG comes with a great cost burden to society, including potentially rising health care costs (also depending on types and costs of treatments). This, along with global quality of life or wellbeing, highlight the importance of extending healthspans.

Although interventions which extend lifespan may also extend healthspan, this is not always the case, suggesting that "lifespan can no longer be the sole parameter of interest," in related research. When increases in life expectancy outpaced improvements in healthspan, public awareness of these 'healthspan lags' began rising around 2017. Scientists have noted that "Chronic diseases of aging are increasing and are inflicting untold costs on human quality of life".

Interventions

Life extension is the concept of extending the human lifespan, either modestly through improvements in medicine or dramatically by increasing the maximum lifespan beyond its generally-settled biological limit of around 125 years. Several researchers in the area, along with "life extensionists", "immortalists", or "longevists" (those who wish to achieve longer lives themselves), postulate that future breakthroughs in tissue rejuvenation, stem cells, regenerative medicine, molecular repair, gene therapy, pharmaceuticals, and organ replacement (such as with artificial organs or xenotransplantations) will eventually enable humans to have indefinite lifespans through complete rejuvenation to a healthy youthful condition (agerasia). The ethical ramifications, if life extension becomes a possibility, are debated by bioethicists.

The sale of purported anti-aging products such as supplements and hormone replacement is a lucrative global industry. For example, the industry that promotes the use of hormones as a treatment for consumers to slow or reverse the aging process in the US market generated about $50 billion of revenue a year in 2009. The use of such hormone products has not been proven to be effective or safe. Similarly, a variety of apps make claims to assist in extending the life of their users, or predicting their lifespans.

Modal logic

From Wikipedia, the free encyclopedia
https://en.wikipedia.org/wiki/Modal_logic

Modal logic is a kind of logic used to represent statements about necessity and possibility. In philosophy and related fields it is used as a tool for understanding concepts such as knowledge, obligation, and causation. For instance, in epistemic modal logic, the formula can be used to represent the statement that is known. In deontic modal logic, that same formula can represent that is a moral obligation. Modal logic considers the inferences that modal statements give rise to. For instance, most epistemic modal logics treat the formula as a tautology, representing the principle that only true statements can count as knowledge. However, this formula is not a tautology in deontic modal logic, since what ought to be true can be false.

Modal logics are formal systems that include unary operators such as and , representing possibility and necessity respectively. For instance the modal formula can be read as "possibly " while can be read as "necessarily ". In the standard relational semantics for modal logic, formulas are assigned truth values relative to a possible world. A formula's truth value at one possible world can depend on the truth values of other formulas at other accessible possible worlds. In particular, is true at a world if is true at some accessible possible world, while is true at a world if is true at every accessible possible world. A variety of proof systems exist which are sound and complete with respect to the semantics one gets by restricting the accessibility relation. For instance, the deontic modal logic D is sound and complete if one requires the accessibility relation to be serial.

While the intuition behind modal logic dates back to antiquity, the first modal axiomatic systems were developed by C. I. Lewis in 1912. The now-standard relational semantics emerged in the mid twentieth century from work by Arthur Prior, Jaakko Hintikka, and Saul Kripke. Recent developments include alternative topological semantics such as neighborhood semantics as well as applications of the relational semantics beyond its original philosophical motivation. Such applications include game theorymoral and legal theoryweb designmultiverse-based set theory, and social epistemology.

Syntax of modal operators

Modal logic differs from other kinds of logic in that it uses modal operators such as and . The former is conventionally read aloud as "necessarily", and can be used to represent notions such as moral or legal obligation, knowledge, historical inevitability, among others. The latter is typically read as "possibly" and can be used to represent notions including permission, ability, compatibility with evidence. While well-formed formulas of modal logic include non-modal formulas such as , it also contains modal ones such as , , , and so on.

Thus, the language of basic propositional logic can be defined recursively as follows.

  1. If is an atomic formula, then is a formula of .
  2. If is a formula of , then is too.
  3. If and are formulas of , then is too.
  4. If is a formula of , then is too.
  5. If is a formula of , then is too.

Modal operators can be added to other kinds of logic by introducing rules analogous to #4 and #5 above. Modal predicate logic is one widely used variant which includes formulas such as . In systems of modal logic where and are duals, can be taken as an abbreviation for , thus eliminating the need for a separate syntactic rule to introduce it. However, separate syntactic rules are necessary in systems where the two operators are not interdefinable.

Common notational variants include symbols such as and in systems of modal logic used to represent knowledge and and in those used to represent belief. These notations are particularly common in systems which use multiple modal operators simultaneously. For instance, a combined epistemic-deontic logic could use the formula read as "I know P is permitted". Systems of modal logic can include infinitely many modal operators distinguished by indices, i.e. , , , and so on.

Semantics

Relational semantics

Basic notions

The standard semantics for modal logic is called the relational semantics. In this approach, the truth of a formula is determined relative to a point which is often called a possible world. For a formula that contains a modal operator, its truth value can depend on what is true at other accessible worlds. Thus, the relational semantics interprets formulas of modal logic using models defined as follows.

  • A relational model is a tuple where:
  1. is a set of possible worlds
  2. is a binary relation on
  3. is a valuation function which assigns a truth value to each pair of an atomic formula and a world, (i.e. where is the set of atomic formulae)

The set is often called the universe. The binary relation is called an accessibility relation, and it controls which worlds can "see" each other for the sake of determining what is true. For example, means that the world is accessible from world . That is to say, the state of affairs known as is a live possibility for . Finally, the function is known as a valuation function. It determines which atomic formulas are true at which worlds.

Then we recursively define the truth of a formula at a world in a model :

  • iff
  • iff
  • iff and
  • iff for every element of , if then
  • iff for some element of , it holds that and

According to this semantics, a formula is necessary with respect to a world if it holds at every world that is accessible from . It is possible if it holds at some world that is accessible from . Possibility thereby depends upon the accessibility relation , which allows us to express the relative nature of possibility. For example, we might say that given our laws of physics it is not possible for humans to travel faster than the speed of light, but that given other circumstances it could have been possible to do so. Using the accessibility relation we can translate this scenario as follows: At all of the worlds accessible to our own world, it is not the case that humans can travel faster than the speed of light, but at one of these accessible worlds there is another world accessible from those worlds but not accessible from our own at which humans can travel faster than the speed of light.

Frames and completeness

The choice of accessibility relation alone can sometimes be sufficient to guarantee the truth or falsity of a formula. For instance, consider a model whose accessibility relation is reflexive. Because the relation is reflexive, we will have that for any regardless of which valuation function is used. For this reason, modal logicians sometimes talk about frames, which are the portion of a relational model excluding the valuation function.

  • A relational frame is a pair where is a set of possible worlds, is a binary relation on .

The different systems of modal logic are defined using frame conditions. A frame is called:

  • reflexive if w R w, for every w in G
  • symmetric if w R u implies u R w, for all w and u in G
  • transitive if w R u and u R q together imply w R q, for all w, u, q in G.
  • serial if, for every w in G there is some u in G such that w R u.
  • Euclidean if, for every u, t, and w, w R u and w R t implies u R t (by symmetry, it also implies t R u, as well as t R t and u R u)

The logics that stem from these frame conditions are:

The Euclidean property along with reflexivity yields symmetry and transitivity. (The Euclidean property can be obtained, as well, from symmetry and transitivity.) Hence if the accessibility relation R is reflexive and Euclidean, R is provably symmetric and transitive as well. Hence for models of S5, R is an equivalence relation, because R is reflexive, symmetric and transitive.

We can prove that these frames produce the same set of valid sentences as do the frames where all worlds can see all other worlds of W (i.e., where R is a "total" relation). This gives the corresponding modal graph which is total complete (i.e., no more edges (relations) can be added). For example, in any modal logic based on frame conditions:

if and only if for some element u of G, it holds that and w R u.

If we consider frames based on the total relation we can just say that

if and only if for some element u of G, it holds that .

We can drop the accessibility clause from the latter stipulation because in such total frames it is trivially true of all w and u that w R u. But this does not have to be the case in all S5 frames, which can still consist of multiple parts that are fully connected among themselves but still disconnected from each other.

All of these logical systems can also be defined axiomatically, as is shown in the next section. For example, in S5, the axioms , and (corresponding to symmetry, transitivity and reflexivity, respectively) hold, whereas at least one of these axioms does not hold in each of the other, weaker logics.

Topological semantics

Modal logic has also been interpreted using topological structures. For instance, the Interior Semantics interprets formulas of modal logic as follows.

A topological model is a tuple where is a topological space and is a valuation function which maps each atomic formula to some subset of . The basic interior semantics interprets formulas of modal logic as follows:

  • iff
  • iff
  • iff and
  • iff for some we have both that and also that for all

Topological approaches subsume relational ones, allowing non-normal modal logics. The extra structure they provide also allows a transparent way of modeling certain concepts such as the evidence or justification one has for one's beliefs. Topological semantics is widely used in recent work in formal epistemology and has antecedents in earlier work such as David Lewis and Angelika Kratzer's logics for counterfactuals.

Axiomatic systems

Diagram of common modal logics; K4W stands for Provability logic, and B on the top corner stands for Brouwer's system of KTB

The first formalizations of modal logic were axiomatic. Numerous variations with very different properties have been proposed since C. I. Lewis began working in the area in 1912. Hughes and Cresswell (1996), for example, describe 42 normal and 25 non-normal modal logics. Zeman (1973) describes some systems Hughes and Cresswell omit.

Modern treatments of modal logic begin by augmenting the propositional calculus with two unary operations, one denoting "necessity" and the other "possibility". The notation of C. I. Lewis, much employed since, denotes "necessarily p" by a prefixed "box" (□p) whose scope is established by parentheses. Likewise, a prefixed "diamond" (◇p) denotes "possibly p". Similar to the quantifiers in first-order logic, "necessarily p" (□p) does not assume the range of quantification (the set of accessible possible worlds in Kripke semantics) to be non-empty, whereas "possibly p" (◇p) often implicitly assumes (viz. the set of accessible possible worlds is non-empty). Regardless of notation, each of these operators is definable in terms of the other in classical modal logic:

  • p (necessarily p) is equivalent to ¬◇¬p ("not possible that not-p")
  • p (possibly p) is equivalent to ¬□¬p ("not necessarily not-p")

Hence □ and ◇ form a dual pair of operators.

In many modal logics, the necessity and possibility operators satisfy the following analogues of de Morgan's laws from Boolean algebra:

"It is not necessary that X" is logically equivalent to "It is possible that not X".
"It is not possible that X" is logically equivalent to "It is necessary that not X".

Precisely what axioms and rules must be added to the propositional calculus to create a usable system of modal logic is a matter of philosophical opinion, often driven by the theorems one wishes to prove; or, in computer science, it is a matter of what sort of computational or deductive system one wishes to model. Many modal logics, known collectively as normal modal logics, include the following rule and axiom:

  • N, Necessitation Rule: If p is a theorem/tautology (of any system/model invoking N), then □p is likewise a theorem (i.e. ).
  • K, Distribution Axiom: □(pq) → (□p → □q).

The weakest normal modal logic, named "K" in honor of Saul Kripke, is simply the propositional calculus augmented by □, the rule N, and the axiom K. K is weak in that it fails to determine whether a proposition can be necessary but only contingently necessary. That is, it is not a theorem of K that if □p is true then □□p is true, i.e., that necessary truths are "necessarily necessary". If such perplexities are deemed forced and artificial, this defect of K is not a great one. In any case, different answers to such questions yield different systems of modal logic.

Adding axioms to K gives rise to other well-known modal systems. One cannot prove in K that if "p is necessary" then p is true. The axiom T remedies this defect:

  • T, Reflexivity Axiom: pp (If p is necessary, then p is the case.)

T holds in most but not all modal logics. Zeman (1973) describes a few exceptions, such as S10.

Other well-known elementary axioms are:

  • 4:
  • B:
  • D:
  • 5:

These yield the systems (axioms in bold, systems in italics):

  • K := K + N
  • T := K + T
  • S4 := T + 4
  • S5 := T + 5
  • D := K + D.

K through S5 form a nested hierarchy of systems, making up the core of normal modal logic. But specific rules or sets of rules may be appropriate for specific systems. For example, in deontic logic, (If it ought to be that p, then it is permitted that p) seems appropriate, but we should probably not include that . In fact, to do so is to commit the naturalistic fallacy (i.e. to state that what is natural is also good, by saying that if p is the case, p ought to be permitted).

The commonly employed system S5 simply makes all modal truths necessary. For example, if p is possible, then it is "necessary" that p is possible. Also, if p is necessary, then it is necessary that p is necessary. Other systems of modal logic have been formulated, in part because S5 does not describe every kind of modality of interest.

Structural proof theory

Sequent calculi and systems of natural deduction have been developed for several modal logics, but it has proven hard to combine generality with other features expected of good structural proof theories, such as purity (the proof theory does not introduce extra-logical notions such as labels) and analyticity (the logical rules support a clean notion of analytic proof). More complex calculi have been applied to modal logic to achieve generality.

Decision methods

Analytic tableaux provide the most popular decision method for modal logics.

Alethic logic

Modalities of necessity and possibility are called alethic modalities. They are also sometimes called special modalities, from the Latin species. Modal logic was first developed to deal with these concepts, and only afterward was extended to others. For this reason, or perhaps for their familiarity and simplicity, necessity and possibility are often casually treated as the subject matter of modal logic. Moreover, it is easier to make sense of relativizing necessity, e.g. to legal, physical, nomological, epistemic, and so on, than it is to make sense of relativizing other notions.

In classical modal logic, a proposition is said to be

  • possible if it is not necessarily false (regardless of whether it is actually true or actually false);
  • necessary if it is not possibly false (i.e. true and necessarily true);
  • contingent if it is not necessarily false and not necessarily true (i.e. possible but not necessarily true);
  • impossible if it is not possibly true (i.e. false and necessarily false).

In classical modal logic, therefore, the notion of either possibility or necessity may be taken to be basic, where these other notions are defined in terms of it in the manner of De Morgan duality. Intuitionistic modal logic treats possibility and necessity as not perfectly symmetric.

For example, suppose that while walking to the convenience store we pass Friedrich's house, and observe that the lights are off. On the way back, we observe that they have been turned on.

  • "Somebody or something turned the lights on" is necessary.
  • "Friedrich turned the lights on", "Friedrich's roommate Max turned the lights on" and "A burglar named Adolf broke into Friedrich's house and turned the lights on" are contingent.
  • All of the above statements are possible.
  • It is impossible that Socrates (who has been dead for over two thousand years) turned the lights on.

(Of course, this analogy does not apply alethic modality in a truly rigorous fashion; for it to do so, it would have to axiomatically make such statements as "human beings cannot rise from the dead", "Socrates was a human being and not an immortal vampire", and "we did not take hallucinogenic drugs which caused us to falsely believe the lights were on", ad infinitum. Absolute certainty of truth or falsehood exists only in the sense of logically constructed abstract concepts such as "it is impossible to draw a triangle with four sides" and "all bachelors are unmarried".)

For those having difficulty with the concept of something being possible but not true, the meaning of these terms may be made more comprehensible by thinking of multiple "possible worlds" (in the sense of Leibniz) or "alternate universes"; something "necessary" is true in all possible worlds, something "possible" is true in at least one possible world.

Physical possibility

Something is physically, or nomically, possible if it is permitted by the laws of physics. For example, current theory is thought to allow for there to be an atom with an atomic number of 126, even if there are no such atoms in existence. In contrast, while it is logically possible to accelerate beyond the speed of light, modern science stipulates that it is not physically possible for material particles or information.

Metaphysical possibility

Philosophers debate if objects have properties independent of those dictated by scientific laws. For example, it might be metaphysically necessary, as some who advocate physicalism have thought, that all thinking beings have bodies and can experience the passage of time. Saul Kripke has argued that every person necessarily has the parents they do have: anyone with different parents would not be the same person.

Metaphysical possibility has been thought to be more restricting than bare logical possibility (i.e., fewer things are metaphysically possible than are logically possible). However, its exact relation (if any) to logical possibility or to physical possibility is a matter of dispute. Philosophers also disagree over whether metaphysical truths are necessary merely "by definition", or whether they reflect some underlying deep facts about the world, or something else entirely.

Epistemic logic

Epistemic modalities (from the Greek episteme, knowledge), deal with the certainty of sentences. The □ operator is translated as "x is certain that…", and the ◇ operator is translated as "For all x knows, it may be true that…" In ordinary speech both metaphysical and epistemic modalities are often expressed in similar words; the following contrasts may help:

A person, Jones, might reasonably say both: (1) "No, it is not possible that Bigfoot exists; I am quite certain of that"; and, (2) "Sure, it's possible that Bigfoots could exist". What Jones means by (1) is that, given all the available information, there is no question remaining as to whether Bigfoot exists. This is an epistemic claim. By (2) he makes the metaphysical claim that it is possible for Bigfoot to exist, even though he does not: there is no physical or biological reason that large, featherless, bipedal creatures with thick hair could not exist in the forests of North America (regardless of whether or not they do). Similarly, "it is possible for the person reading this sentence to be fourteen feet tall and named Chad" is metaphysically true (such a person would not somehow be prevented from doing so on account of their height and name), but not alethically true unless you match that description, and not epistemically true if it is known that fourteen-foot-tall human beings have never existed.

From the other direction, Jones might say, (3) "It is possible that Goldbach's conjecture is true; but also possible that it is false", and also (4) "if it is true, then it is necessarily true, and not possibly false". Here Jones means that it is epistemically possible that it is true or false, for all he knows (Goldbach's conjecture has not been proven either true or false), but if there is a proof (heretofore undiscovered), then it would show that it is not logically possible for Goldbach's conjecture to be false—there could be no set of numbers that violated it. Logical possibility is a form of alethic possibility; (4) makes a claim about whether it is possible (i.e., logically speaking) that a mathematical truth to have been false, but (3) only makes a claim about whether it is possible, for all Jones knows, (i.e., speaking of certitude) that the mathematical claim is specifically either true or false, and so again Jones does not contradict himself. It is worthwhile to observe that Jones is not necessarily correct: It is possible (epistemically) that Goldbach's conjecture is both true and unprovable.

Epistemic possibilities also bear on the actual world in a way that metaphysical possibilities do not. Metaphysical possibilities bear on ways the world might have been, but epistemic possibilities bear on the way the world may be (for all we know). Suppose, for example, that I want to know whether or not to take an umbrella before I leave. If you tell me "it is possible that it is raining outside" – in the sense of epistemic possibility – then that would weigh on whether or not I take the umbrella. But if you just tell me that "it is possible for it to rain outside" – in the sense of metaphysical possibility – then I am no better off for this bit of modal enlightenment.

Some features of epistemic modal logic are in debate. For example, if x knows that p, does x know that it knows that p? That is to say, should □P → □□P be an axiom in these systems? While the answer to this question is unclear, there is at least one axiom that is generally included in epistemic modal logic, because it is minimally true of all normal modal logics (see the section on axiomatic systems):

  • K, Distribution Axiom: .

It has been questioned whether the epistemic and alethic modalities should be considered distinct from each other. The criticism states that there is no real difference between "the truth in the world" (alethic) and "the truth in an individual's mind" (epistemic). An investigation has not found a single language in which alethic and epistemic modalities are formally distinguished, as by the means of a grammatical mood.

Temporal logic

Temporal logic is an approach to the semantics of expressions with tense, that is, expressions with qualifications of when. Some expressions, such as '2 + 2 = 4', are true at all times, while tensed expressions such as 'John is happy' are only true sometimes.

In temporal logic, tense constructions are treated in terms of modalities, where a standard method for formalizing talk of time is to use two pairs of operators, one for the past and one for the future (P will just mean 'it is presently the case that P'). For example:

FP : It will sometimes be the case that P
GP : It will always be the case that P
PP : It was sometime the case that P
HP : It has always been the case that P

There are then at least three modal logics that we can develop. For example, we can stipulate that,

is the case at some time t
is the case at every time t

Or we can trade these operators to deal only with the future (or past). For example,

or,

The operators F and G may seem initially foreign, but they create normal modal systems. FP is the same as ¬G¬P. We can combine the above operators to form complex statements. For example, PP → □PP says (effectively), Everything that is past and true is necessary.

It seems reasonable to say that possibly it will rain tomorrow, and possibly it will not; on the other hand, since we cannot change the past, if it is true that it rained yesterday, it cannot be true that it may not have rained yesterday. It seems the past is "fixed", or necessary, in a way the future is not. This is sometimes referred to as accidental necessity. But if the past is "fixed", and everything that is in the future will eventually be in the past, then it seems plausible to say that future events are necessary too.

Similarly, the problem of future contingents considers the semantics of assertions about the future: is either of the propositions 'There will be a sea battle tomorrow', or 'There will not be a sea battle tomorrow' now true? Considering this thesis led Aristotle to reject the principle of bivalence for assertions concerning the future.

Additional binary operators are also relevant to temporal logics (see Linear temporal logic).

Versions of temporal logic can be used in computer science to model computer operations and prove theorems about them. In one version, ◇P means "at a future time in the computation it is possible that the computer state will be such that P is true"; □P means "at all future times in the computation P will be true". In another version, ◇P means "at the immediate next state of the computation, P might be true"; □P means "at the immediate next state of the computation, P will be true". These differ in the choice of Accessibility relation. (P always means "P is true at the current computer state".) These two examples involve nondeterministic or not-fully-understood computations; there are many other modal logics specialized to different types of program analysis. Each one naturally leads to slightly different axioms.

Deontic logic

Likewise talk of morality, or of obligation and norms generally, seems to have a modal structure. The difference between "You must do this" and "You may do this" looks a lot like the difference between "This is necessary" and "This is possible". Such logics are called deontic, from the Greek for "duty".

Deontic logics commonly lack the axiom T semantically corresponding to the reflexivity of the accessibility relation in Kripke semantics: in symbols, . Interpreting □ as "it is obligatory that", T informally says that every obligation is true. For example, if it is obligatory not to kill others (i.e. killing is morally forbidden), then T implies that people actually do not kill others. The consequent is obviously false.

Instead, using Kripke semantics, we say that though our own world does not realize all obligations, the worlds accessible to it do (i.e., T holds at these worlds). These worlds are called idealized worlds. P is obligatory with respect to our own world if at all idealized worlds accessible to our world, P holds. Though this was one of the first interpretations of the formal semantics, it has recently come under criticism.

One other principle that is often (at least traditionally) accepted as a deontic principle is D, , which corresponds to the seriality (or extendability or unboundedness) of the accessibility relation. It is an embodiment of the Kantian idea that "ought implies can". (Clearly the "can" can be interpreted in various senses, e.g. in a moral or alethic sense.)

Intuitive problems with deontic logic

When we try to formalize ethics with standard modal logic, we run into some problems. Suppose that we have a proposition K: you have stolen some money, and another, Q: you have stolen a small amount of money. Now suppose we want to express the thought that "if you have stolen some money, it ought to be a small amount of money". There are two likely candidates,

(1)
(2)

But (1) and K together entail □Q, which says that it ought to be the case that you have stolen a small amount of money. This surely is not right, because you ought not to have stolen anything at all. And (2) does not work either: If the right representation of "if you have stolen some money it ought to be a small amount" is (2), then the right representation of (3) "if you have stolen some money then it ought to be a large amount" is . Now suppose (as seems reasonable) that you ought not to steal anything, or . But then we can deduce via and (the contrapositive of ); so sentence (3) follows from our hypothesis (of course the same logic shows sentence (2)). But that cannot be right, and is not right when we use natural language. Telling someone they should not steal certainly does not imply that they should steal large amounts of money if they do engage in theft.

Doxastic logic

Doxastic logic concerns the logic of belief (of some set of agents). The term doxastic is derived from the ancient Greek doxa which means "belief". Typically, a doxastic logic uses □, often written "B", to mean "It is believed that", or when relativized to a particular agent s, "It is believed by s that".

Extensions

Modal logics may be extended to fuzzy form with calculi in the class of fuzzy Kripke models.

Modal logics may also be enhanced via base-extension semantics for the classical propositional systems. In this case, the validity of a formula can be shown by an inductive definition generated by provability in a ‘base’ of atomic rules. ⁠

Intuitionistic modal logics are used in different areas of application, and they have often risen from different sources. The areas include the foundations of mathematics, computer science and philosophy. In these approaches, often modalities are added to intuitionistic logic to create new intuitionistic connectives and to simulate the monadic elements of intuitionistic first order logic.

Metaphysical questions

In the most common interpretation of modal logic, one considers "logically possible worlds". If a statement is true in all possible worlds, then it is a necessary truth. If a statement happens to be true in our world, but is not true in all possible worlds, then it is a contingent truth. A statement that is true in some possible world (not necessarily our own) is called a possible truth.

Under this "possible worlds idiom", to maintain that Bigfoot's existence is possible but not actual, one says, "There is some possible world in which Bigfoot exists; but in the actual world, Bigfoot does not exist". However, it is unclear what this claim commits us to. Are we really alleging the existence of possible worlds, every bit as real as our actual world, just not actual? Saul Kripke believes that 'possible world' is something of a misnomer – that the term 'possible world' is just a useful way of visualizing the concept of possibility. For him, the sentences "you could have rolled a 4 instead of a 6" and "there is a possible world where you rolled a 4, but you rolled a 6 in the actual world" are not significantly different statements, and neither commit us to the existence of a possible world. David Lewis, on the other hand, made himself notorious by biting the bullet, asserting that all merely possible worlds are as real as our own, and that what distinguishes our world as actual is simply that it is indeed our world – this world. That position is a major tenet of "modal realism". Some philosophers decline to endorse any version of modal realism, considering it ontologically extravagant, and prefer to seek various ways to paraphrase away these ontological commitments. Robert Adams holds that 'possible worlds' are better thought of as 'world-stories', or consistent sets of propositions. Thus, it is possible that you rolled a 4 if such a state of affairs can be described coherently.

Computer scientists will generally pick a highly specific interpretation of the modal operators specialized to the particular sort of computation being analysed. In place of "all worlds", you may have "all possible next states of the computer", or "all possible future states of the computer".

Further applications

Modal logics have begun to be used in areas of the humanities such as literature, poetry, art and history. In the philosophy of religion, modal logics are commonly used in arguments for the existence of God.

History

The basic ideas of modal logic date back to antiquity. Aristotle developed a modal syllogistic in Book I of his Prior Analytics (ch. 8–22), which Theophrastus attempted to improve. There are also passages in Aristotle's work, such as the famous sea-battle argument in De Interpretatione §9, that are now seen as anticipations of the connection of modal logic with potentiality and time. In the Hellenistic period, the logicians Diodorus Cronus, Philo the Dialectician and the Stoic Chrysippus each developed a modal system that accounted for the interdefinability of possibility and necessity, accepted axiom T (see below), and combined elements of modal logic and temporal logic in attempts to solve the notorious Master Argument. The earliest formal system of modal logic was developed by Avicenna, who ultimately developed a theory of "temporally modal" syllogistic. Modal logic as a self-aware subject owes much to the writings of the Scholastics, in particular William of Ockham and John Duns Scotus, who reasoned informally in a modal manner, mainly to analyze statements about essence and accident.

In the 19th century, Hugh MacColl made innovative contributions to modal logic, but did not find much acknowledgment. C. I. Lewis founded modern modal logic in a series of scholarly articles beginning in 1912 with "Implication and the Algebra of Logic". Lewis was led to invent modal logic, and specifically strict implication, on the grounds that classical logic grants paradoxes of material implication such as the principle that a falsehood implies any proposition. This work culminated in his 1932 book Symbolic Logic (with C. H. Langford), which introduced the five systems S1 through S5.

After Lewis, modal logic received little attention for several decades. Nicholas Rescher has argued that this was because Bertrand Russell rejected it. However, Jan Dejnozka has argued against this view, stating that a modal system which Dejnozka calls "MDL" is described in Russell's works, although Russell did believe the concept of modality to "come from confusing propositions with propositional functions", as he wrote in The Analysis of Matter.

Ruth C. Barcan (later Ruth Barcan Marcus) developed the first axiomatic systems of quantified modal logic — first and second order extensions of Lewis' S2, S4, and S5Arthur Norman Prior warned her to prepare well in the debates concerning quantified modal logic with Willard Van Orman Quine, because of bias against modal logic.

The contemporary era in modal semantics began in 1959, when Saul Kripke (then only a 18-year-old Harvard University undergraduate) introduced the now-standard Kripke semantics for modal logics. These are commonly referred to as "possible worlds" semantics. Kripke and A. N. Prior had previously corresponded at some length. Kripke semantics is basically simple, but proofs are eased using semantic-tableaux or analytic tableaux, as explained by E. W. Beth.

A. N. Prior created modern temporal logic, closely related to modal logic, in 1957 by adding modal operators [F] and [P] meaning "eventually" and "previously". Vaughan Pratt introduced dynamic logic in 1976. In 1977, Amir Pnueli proposed using temporal logic to formalise the behaviour of continually operating concurrent programs. Flavors of temporal logic include propositional dynamic logic (PDL), (propositional) linear temporal logic (LTL), computation tree logic (CTL), Hennessy–Milner logic, and T.

The mathematical structure of modal logic, namely Boolean algebras augmented with unary operations (often called modal algebras), began to emerge with J. C. C. McKinsey's 1941 proof that S2 and S4 are decidable, and reached full flower in the work of Alfred Tarski and his student Bjarni Jónsson (Jónsson and Tarski 1951–52). This work revealed that S4 and S5 are models of interior algebra, a proper extension of Boolean algebra originally designed to capture the properties of the interior and closure operators of topology. Texts on modal logic typically do little more than mention its connections with the study of Boolean algebras and topology. For a thorough survey of the history of formal modal logic and of the associated mathematics, see Robert Goldblatt (2006).

Senescence

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