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Tuesday, July 17, 2018

Mineralogy

From Wikipedia, the free encyclopedia
 
Mineralogy is a mixture of chemistry, materials science, physics and geology.

Mineralogy is a subject of geology specializing in the scientific study of chemistry, crystal structure, and physical (including optical) properties of minerals and mineralized artifacts. Specific studies within mineralogy include the processes of mineral origin and formation, classification of minerals, their geographical distribution, as well as their utilization.

History

Page from Treatise on mineralogy by Friedrich Mohs (1825)
 
The Moon Mineralogy Mapper, a spectrometer that mapped the lunar surface[3]
 
Early writing on mineralogy, especially on gemstones, comes from ancient Babylonia, the ancient Greco-Roman world, ancient and medieval China, and Sanskrit texts from ancient India and the ancient Islamic World.[4] Books on the subject included the Naturalis Historia of Pliny the Elder, which not only described many different minerals but also explained many of their properties, and Kitab al Jawahir (Book of Precious Stones) by Persian scientist Al Biruni. The German Renaissance specialist Georgius Agricola wrote works such as De re metallica (On Metals, 1556) and De Natura Fossilium (On the Nature of Rocks, 1546) which began the scientific approach to the subject. Systematic scientific studies of minerals and rocks developed in post-Renaissance Europe.[4] The modern study of mineralogy was founded on the principles of crystallography (the origins of geometric crystallography, itself, can be traced back to the mineralogy practiced in the eighteenth and nineteenth centuries) and to the microscopic study of rock sections with the invention of the microscope in the 17th century.[4]

Nicholas Steno first observed the law of constancy of interfacial angles (also known as the first law of crystallography) in quartz crystals in 1669.[5]:4 This was later generalized and established experimentally by Jean-Baptiste L. Romé de l'Islee in 1783.[6] René Just Haüy, the "father of modern crystallography", showed that crystals are periodic and established that the orientations of crystal faces can be expressed in terms of rational numbers, as later encoded in the Miller indices.[5]:4 In 1814, Jöns Jacob Berzelius introduced a classification of minerals based on their chemistry rather than their crystal structure.[7] William Nicol developed the Nicol prism, which polarizes light, in 1827–1828 while studying fossilized wood; Henry Clifton Sorby showed that thin sections of minerals could be identified by their optical properties using a polarizing microscope.[5]:4[7]:15 James D. Dana published his first edition of A System of Mineralogy in 1837, and in a later edition introduced a chemical classification that is still the standard.[5]:4[7]:15 X-ray diffraction was demonstrated by Max von Laue in 1912, and developed into a tool for analyzing the crystal structure of minerals by the father/son team of William Henry Bragg and William Lawrence Bragg.[5]:4

More recently, driven by advances in experimental technique (such as neutron diffraction) and available computational power, the latter of which has enabled extremely accurate atomic-scale simulations of the behaviour of crystals, the science has branched out to consider more general problems in the fields of inorganic chemistry and solid-state physics. It, however, retains a focus on the crystal structures commonly encountered in rock-forming minerals (such as the perovskites, clay minerals and framework silicates). In particular, the field has made great advances in the understanding of the relationship between the atomic-scale structure of minerals and their function; in nature, prominent examples would be accurate measurement and prediction of the elastic properties of minerals, which has led to new insight into seismological behaviour of rocks and depth-related discontinuities in seismograms of the Earth's mantle. To this end, in their focus on the connection between atomic-scale phenomena and macroscopic properties, the mineral sciences (as they are now commonly known) display perhaps more of an overlap with materials science than any other discipline.

Physical properties

Calcite is a carbonate mineral (CaCO3) with a rhombohedral crystal structure.
 
Aragonite is an orthorhombic polymorph of calcite.

An initial step in identifying a mineral is to examine its physical properties, many of which can be measured on a hand sample. These can be classified into density (often given as specific gravity); measures of mechanical cohesion (hardness, tenacity, cleavage, fracture, parting); macroscopic visual properties (luster, color, streak, luminescence, diaphaneity); magnetic and electric properties; radioactivity and solubility in hydrogen chloride (HCl).[5]:97–113[8]:39–53

Hardness is determined by comparison with other minerals. In the Mohs scale, a standard set of minerals are numbered in order of increasing hardness from 1 (talc) to 10 (diamond). A harder mineral will scratch a softer, so an unknown mineral can be placed in this scale by which minerals it scratches and which scratch it. A few minerals such as calcite and kyanite have a hardness that depends significantly on direction.[9]:254–255 Hardness can also be measured on an absolute scale using a sclerometer; compared to the absolute scale, the Mohs scale is nonlinear.[8]:52

Tenacity refers to the way a mineral behaves when it is broken, crushed, bent or torn. A mineral can be brittle, malleable, sectile, ductile, flexible or elastic. An important influence on tenacity is the type of chemical bond (e.g., ionic or metallic).[9]:255–256 Of the other measures of mechanical cohesion, cleavage is the tendency to break along certain crystallographic planes. It is described by the quality (e.g., perfect or fair) and the orientation of the plane in crystallographic nomenclature. Parting is the tendency to break along planes of weakness due to pressure, twinning or exsolution. Where these two kinds of break do not occur, fracture is a less orderly form that may be conchoidal (having smooth curves resembling the interior of a shell), fibrous, splintery, hackly (jagged with sharp edges), or uneven.[9]:253–254

If the mineral is well crystallized, it will also have a distinctive crystal habit (for example, hexagonal, columnar, botryoidal) that reflects the crystal structure or internal arrangement of atoms.[8]:40–41 It is also affected by crystal defects and twinning. Many crystals are polymorphic, having more than one possible crystal structure depending on factors such as pressure and temperature.[5]:66–68[8]:126

Crystal structure

The perovskite crystal structure. The most abundant mineral in the Earth, bridgmanite, has this structure.[10] Its chemical formula is (Mg,Fe)SiO3; the red spheres are oxygen, the blue spheres silicon and the green spheres magnesium or iron.

The crystal structure is the arrangement of atoms in a crystal. It is represented by a lattice of points which repeats a basic pattern, called a unit cell, in three dimensions. The lattice can be characterized by its symmetries and by the dimensions of the unit cell. These dimensions are represented by three Miller indices.[11]:91–92 The lattice remains unchanged by certain symmetry operations about any given point in the lattice: reflection, rotation, inversion, and rotary inversion, a combination of rotation and reflection. Together, they make up a mathematical object called a crystallographic point group or crystal class. There are 32 possible crystal classes. In addition, there are operations that displace all the points: translation, screw axis, and glide plane. In combination with the point symmetries, they form 230 possible space groups.[11]:125–126

Most geology departments have X-ray powder diffraction equipment to analyze the crystal structures of minerals.[8]:54–55 X-rays have wavelengths that are the same order of magnitude as the distances between atoms. Diffraction, the constructive and destructive interference between waves scattered at different atoms, leads to distinctive patterns of high and low intensity that depend on the geometry of the crystal. In a sample that is ground to a powder, the X-rays sample a random distribution of all crystal orientations.[12] Powder diffraction can distinguish between minerals that may appear the same in a hand sample, for example quartz and its polymorphs tridymite and cristobalite.[8]:54

Isomorphous minerals of different compositions have similar powder diffraction patterns, the main difference being in spacing and intensity of lines. For example, the NaCl (halite) crystal structure is space group Fm3m; this structure is shared by sylvite (KCl), periclase (MgO), bunsenite (NiO), galena (PbS), alabandite (MnS), chlorargyrite (AgCl), and osbornite (TiN).[9]:150–151

Chemical elements

Portable Micro-X-ray fluorescence machine

A few minerals are chemical elements, including sulfur, copper, silver, and gold, but the vast majority are compounds. The classical method for identifying composition is wet chemical analysis, which involves dissolving a mineral in an acid such as hydrochloric acid (HCl). The elements in solution are then identified using colorimetry, volumetric analysis or gravimetric analysis.[9]:224–225

Since 1960, most chemistry analysis is done using instruments. One of these, atomic absorption spectroscopy, is similar to wet chemistry in that the sample must still be dissolved, but it is much faster and cheaper. The solution is vaporized and its absorption spectrum is measured in the visible and ultraviolet range.[9]:225–226 Other techniques are X-ray fluorescence, electron microprobe analysis and optical emission spectrography.[9]:227–232

Optical

Photomicrograph of olivine adcumulate, Archaean Komatiite, Agnew, Western Australia.

In addition to macroscopic properties such as color or lustre, minerals have properties that require a polarizing microscope to observe.

Transmitted light

When light passes from air or a vacuum into a transparent crystal, some of it is reflected at the surface and some refracted. The latter is a bending of the light path that occurs because the speed of light changes as it goes into the crystal; Snell's law relates the bending angle to the Refractive index, the ratio of speed in a vacuum to speed in the crystal. Crystals whose point symmetry group falls in the cubic system are isotropic: the index does not depend on direction. All other crystals are anisotropic: light passing through them is broken up into two plane polarized rays that travel at different speeds and refract at different angles.[9]:289–291

A polarizing microscope is similar to an ordinary microscope, but it has two plane-polarized filters, a (polarizer) below the sample and an analyzer above it, polarized perpendicular to each other. Light passes successively through the polarizer, the sample and the analyzer. If there is no sample, the analyzer blocks all the light from the polarizer. However, an anisotropic sample will generally change the polarization so some of the light can pass through. Thin sections and powders can be used as samples.[9]:293–294

When an isotropic crystal is viewed, it appears dark because it does not change the polarization of the light. However, when it is immersed in a calibrated liquid with a lower index of refraction and the microscope is thrown out of focus, a bright line called a Becke line appears around the perimeter of the crystal. By observing the presence or absence of such lines in liquids with different indices, the index of the crystal can be estimated, usually to within ± 0.003.[9]:294–295

Systematic

Hanksite, Na22K(SO4)9(CO3)2Cl, one of the few minerals that is considered a carbonate and a sulfate

Systematic mineralogy is the identification and classification of minerals by their properties. Historically, mineralogy was heavily concerned with taxonomy of the rock-forming minerals. In 1959, the International Mineralogical Association formed the Commission of New Minerals and Mineral Names to rationalize the nomenclature and regulate the introduction of new names. In July 2006, it was merged with the Commission on Classification of Minerals to form the Commission on New Minerals, Nomenclature, and Classification.[13] There are over 6,000 named and unnamed minerals, and about 100 are discovered each year.[14] The Manual of Mineralogy places minerals in the following classes: native elements, sulfides, sulfosalts, oxides and hydroxides, halides, carbonates, nitrates and borates, sulfates, chromates, molybdates and tungstates, phosphates, arsenates and vanadates, and silicates.[9]

Formation environments

The environments of mineral formation and growth are highly varied, ranging from slow crystallization at the high temperatures and pressures of igneous melts deep within the Earth's crust to the low temperature precipitation from a saline brine at the Earth's surface.

Various possible methods of formation include:[15]

Biomineralogy

Biomineralogy is a cross-over field between mineralogy, paleontology and biology. It is the study of how plants and animals stabilize minerals under biological control, and the sequencing of mineral replacement of those minerals after deposition.[16] It uses techniques from chemical mineralogy, especially isotopic studies, to determine such things as growth forms in living plants and animals[17][18] as well as things like the original mineral content of fossils.[19]

A new approach to mineralogy called "mineral evolution" explores the co-evolution of the geosphere and biosphere, including the role of minerals in the origin of life and processes as mineral-catalyzed organic synthesis and the selective adsorption of organic molecules on mineral surfaces.[20][21]

Uses

A color chart of some raw forms of commercially valuable metals.[22]

Minerals are essential to various needs within human society, such as minerals used as ores for essential components of metal products used in various commodities and machinery, essential components to building materials such as limestone, marble, granite, gravel, glass, plaster, cement, etc.[15] Minerals are also used in fertilizers to enrich the growth of agricultural crops.

Collecting

Mineral collecting is also a recreational study and collection hobby, with clubs and societies representing the field.[23][24] Museums, such as the Smithsonian National Museum of Natural History Hall of Geology, Gems, and Minerals, the Natural History Museum of Los Angeles County, the Natural History Museum, London, and the private Mim Mineral Museum in Beirut, Lebanon,[25][26] have popular collections of mineral specimens on permanent display.

Materials science

From Wikipedia, the free encyclopedia
 

The interdisciplinary field of materials science, also commonly termed materials science and engineering is the design and discovery of new materials, particularly solids. The intellectual origins of materials science stem from the Enlightenment, when researchers began to use analytical thinking from chemistry, physics, and engineering to understand ancient, phenomenological observations in metallurgy and mineralogy. Materials science still incorporates elements of physics, chemistry, and engineering. As such, the field was long considered by academic institutions as a sub-field of these related fields. Beginning in the 1940s, materials science began to be more widely recognized as a specific and distinct field of science and engineering, and major technical universities around the world created dedicated schools of the study, within either the Science or Engineering schools, hence the naming.
Materials science is a syncretic discipline hybridizing metallurgy, ceramics, solid-state physics, and chemistry. It is the first example of a new academic discipline emerging by fusion rather than fission.[3]
Many of the most pressing scientific problems humans currently face are due to the limits of the materials that are available and how they are used. Thus, breakthroughs in materials science are likely to affect the future of technology significantly.[4][5]

Materials scientists emphasize understanding how the history of a material (its processing) influences its structure, and thus the material's properties and performance. The understanding of processing-structure-properties relationships is called the § materials paradigm. This paradigm is used to advance understanding in a variety of research areas, including nanotechnology, biomaterials, and metallurgy. Materials science is also an important part of forensic engineering and failure analysis - investigating materials, products, structures or components which fail or do not function as intended, causing personal injury or damage to property. Such investigations are key to understanding, for example, the causes of various aviation accidents and incidents.

History

A late Bronze Age sword or dagger blade.

The material of choice of a given era is often a defining point. Phrases such as Stone Age, Bronze Age, Iron Age, and Steel Age are historic, if arbitrary examples. Originally deriving from the manufacture of ceramics and its putative derivative metallurgy, materials science is one of the oldest forms of engineering and applied science. Modern materials science evolved directly from metallurgy, which itself evolved from mining and (likely) ceramics and earlier from the use of fire. A major breakthrough in the understanding of materials occurred in the late 19th century, when the American scientist Josiah Willard Gibbs demonstrated that the thermodynamic properties related to atomic structure in various phases are related to the physical properties of a material. Important elements of modern materials science are a product of the space race: the understanding and engineering of the metallic alloys, and silica and carbon materials, used in building space vehicles enabling the exploration of space. Materials science has driven, and been driven by, the development of revolutionary technologies such as rubbers, plastics, semiconductors, and biomaterials.

Before the 1960s (and in some cases decades after), many materials science departments were named metallurgy departments, reflecting the 19th and early 20th century emphasis on metals. The growth of materials science in the United States was catalyzed in part by the Advanced Research Projects Agency, which funded a series of university-hosted laboratories in the early 1960s "to expand the national program of basic research and training in the materials sciences."[6] The field has since broadened to include every class of materials, including ceramics, polymers, semiconductors, magnetic materials, medical implant materials, biological materials, and nanomaterials, with modern materials classed within 3 distinct groups: Ceramic, Metal or Polymer. The prominent change in materials science during the last two decades is active usage of computer simulation methods to find new compounds, predict various properties, and as a result design new materials at a much greater rate than previous years.

Fundamentals


The materials paradigm represented in the form of a tetrahedron.

A material is defined as a substance (most often a solid, but other condensed phases can be included) that is intended to be used for certain applications.[7] There are a myriad of materials around us—they can be found in anything from buildings to spacecraft. Materials can generally be further divided into two classes: crystalline and non-crystalline. The traditional examples of materials are metals, semiconductors, ceramics and polymers.[8] New and advanced materials that are being developed include nanomaterials, biomaterials,[9] and energy materials to name a few.

The basis of materials science involves studying the structure of materials, and relating them to their properties. Once a materials scientist knows about this structure-property correlation, they can then go on to study the relative performance of a material in a given application. The major determinants of the structure of a material and thus of its properties are its constituent chemical elements and the way in which it has been processed into its final form. These characteristics, taken together and related through the laws of thermodynamics and kinetics, govern a material's microstructure, and thus its properties.

Structure

As mentioned above, structure is one of the most important components of the field of materials science. Materials science examines the structure of materials from the atomic scale, all the way up to the macro scale. Characterization is the way materials scientists examine the structure of a material. This involves methods such as diffraction with X-rays, electrons, or neutrons, and various forms of spectroscopy and chemical analysis such as Raman spectroscopy, energy-dispersive spectroscopy (EDS), chromatography, thermal analysis, electron microscope analysis, etc. Structure is studied at various levels, as detailed below.

Atomic structure

This deals with the atoms of the materials, and how they are arranged to give molecules, crystals, etc. Much of the electrical, magnetic and chemical properties of materials arise from this level of structure. The length scales involved are in angstroms. The way in which the atoms and molecules are bonded and arranged is fundamental to studying the properties and behavior of any material.

Nanostructure

Buckminsterfullerene nanostructure.

Nanostructure deals with objects and structures that are in the 1—100 nm range.[10] In many materials, atoms or molecules agglomerate together to form objects at the nanoscale. This causes many interesting electrical, magnetic, optical, and mechanical properties.

In describing nanostructures it is necessary to differentiate between the number of dimensions on the nanoscale. Nanotextured surfaces have one dimension on the nanoscale, i.e., only the thickness of the surface of an object is between 0.1 and 100 nm. Nanotubes have two dimensions on the nanoscale, i.e., the diameter of the tube is between 0.1 and 100 nm; its length could be much greater. Finally, spherical nanoparticles have three dimensions on the nanoscale, i.e., the particle is between 0.1 and 100 nm in each spatial dimension. The terms nanoparticles and ultrafine particles (UFP) often are used synonymously although UFP can reach into the micrometre range. The term 'nanostructure' is often used when referring to magnetic technology. Nanoscale structure in biology is often called ultrastructure.

Materials which atoms and molecules form constituents in the nanoscale (i.e., they form nanostructure) are called nanomaterials. Nanomaterials are subject of intense research in the materials science community due to the unique properties that they exhibit.

Microstructure

Microstructure of pearlite.

Microstructure is defined as the structure of a prepared surface or thin foil of material as revealed by a microscope above 25× magnification. It deals with objects from 100 nm to a few cm. The microstructure of a material (which can be broadly classified into metallic, polymeric, ceramic and composite) can strongly influence physical properties such as strength, toughness, ductility, hardness, corrosion resistance, high/low temperature behavior, wear resistance, and so on. Most of the traditional materials (such as metals and ceramics) are microstructured.

The manufacture of a perfect crystal of a material is physically impossible. For example, any crystalline material will contain defects such as precipitates, grain boundaries (Hall–Petch relationship), vacancies, interstitial atoms or substitutional atoms. The microstructure of materials reveals these larger defects, so that they can be studied, with significant advances in simulation resulting in exponentially increasing understanding of how defects can be used to enhance material properties.

Macro structure

Macro structure is the appearance of a material in the scale millimeters to meters—it is the structure of the material as seen with the naked eye.

Crystallography

Crystal structure of a perovskite with a chemical formula ABX3.[11]

Crystallography is the science that examines the arrangement of atoms in crystalline solids. Crystallography is a useful tool for materials scientists. In single crystals, the effects of the crystalline arrangement of atoms is often easy to see macroscopically, because the natural shapes of crystals reflect the atomic structure. Further, physical properties are often controlled by crystalline defects. The understanding of crystal structures is an important prerequisite for understanding crystallographic defects. Mostly, materials do not occur as a single crystal, but in polycrystalline form, i.e., as an aggregate of small crystals with different orientations. Because of this, the powder diffraction method, which uses diffraction patterns of polycrystalline samples with a large number of crystals, plays an important role in structural determination. Most materials have a crystalline structure, but some important materials do not exhibit regular crystal structure. Polymers display varying degrees of crystallinity, and many are completely noncrystalline. Glass, some ceramics, and many natural materials are amorphous, not possessing any long-range order in their atomic arrangements. The study of polymers combines elements of chemical and statistical thermodynamics to give thermodynamic and mechanical, descriptions of physical properties.

Bonding

To obtain a full understanding of the material structure and how it relates to its properties, the materials scientist must study how the different atoms, ions and molecules are arranged and bonded to each other. This involves the study and use of quantum chemistry or quantum physics. Solid-state physics, solid-state chemistry and physical chemistry are also involved in the study of bonding and structure.

Synthesis and processing

Synthesis and processing involves the creation of a material with the desired micro-nanostructure. From an engineering standpoint, a material cannot be used in industry if no economical production method for it has been developed. Thus, the processing of materials is vital to the field of materials science.

Different materials require different processing or synthesis methods. For example, the processing of metals has historically been very important and is studied under the branch of materials science named physical metallurgy. Also, chemical and physical methods are also used to synthesize other materials such as polymers, ceramics, thin films, etc. As of the early 21st century, new methods are being developed to synthesize nanomaterials such as graphene.

Thermodynamics

A phase diagram for a binary system displaying a eutectic point.

Thermodynamics is concerned with heat and temperature and their relation to energy and work. It defines macroscopic variables, such as internal energy, entropy, and pressure, that partly describe a body of matter or radiation. It states that the behavior of those variables is subject to general constraints, that are common to all materials, not the peculiar properties of particular materials. These general constraints are expressed in the four laws of thermodynamics. Thermodynamics describes the bulk behavior of the body, not the microscopic behaviors of the very large numbers of its microscopic constituents, such as molecules. The behavior of these microscopic particles is described by, and the laws of thermodynamics are derived from, statistical mechanics.

The study of thermodynamics is fundamental to materials science. It forms the foundation to treat general phenomena in materials science and engineering, including chemical reactions, magnetism, polarizability, and elasticity. It also helps in the understanding of phase diagrams and phase equilibrium.

Kinetics

Chemical kinetics is the study of the rates at which systems that are out of equilibrium change under the influence of various forces. When applied to materials science, it deals with how a material changes with time (moves from non-equilibrium to equilibrium state) due to application of a certain field. It details the rate of various processes evolving in materials including shape, size, composition and structure. Diffusion is important in the study of kinetics as this is the most common mechanism by which materials undergo change.
Kinetics is essential in processing of materials because, among other things, it details how the microstructure changes with application of heat.

In research

Materials science has received much attention from researchers. In most universities, many departments ranging from physics to chemistry to chemical engineering, along with materials science departments, are involved in materials research. Research in materials science is vibrant and consists of many avenues. The following list is in no way exhaustive. It serves only to highlight certain important research areas.

Nanomaterials

A scanning electron microscopy image of carbon nanotubes bundles

Nanomaterials describe, in principle, materials of which a single unit is sized (in at least one dimension) between 1 and 1000 nanometers (10−9 meter) but is usually 1—100 nm.

Nanomaterials research takes a materials science-based approach to nanotechnology, leveraging advances in materials metrology and synthesis which have been developed in support of microfabrication research. Materials with structure at the nanoscale often have unique optical, electronic, or mechanical properties.

The field of nanomaterials is loosely organized, like the traditional field of chemistry, into organic (carbon-based) nanomaterials such as fullerenes, and inorganic nanomaterials based on other elements, such as silicon. Examples of nanomaterials include fullerenes, carbon nanotubes, nanocrystals, etc.

Biomaterials

The iridescent nacre inside a nautilus shell.

A biomaterial is any matter, surface, or construct that interacts with biological systems. The study of biomaterials is called bio materials science. It has experienced steady and strong growth over its history, with many companies investing large amounts of money into developing new products. Biomaterials science encompasses elements of medicine, biology, chemistry, tissue engineering, and materials science.

Biomaterials can be derived either from nature or synthesized in a laboratory using a variety of chemical approaches using metallic components, polymers, bioceramics, or composite materials. They are often used and/or adapted for a medical application, and thus comprises whole or part of a living structure or biomedical device which performs, augments, or replaces a natural function. Such functions may be benign, like being used for a heart valve, or may be bioactive with a more interactive functionality such as hydroxylapatite coated hip implants. Biomaterials are also used every day in dental applications, surgery, and drug delivery. For example, a construct with impregnated pharmaceutical products can be placed into the body, which permits the prolonged release of a drug over an extended period of time. A biomaterial may also be an autograft, allograft or xenograft used as an organ transplant material.

Electronic, optical, and magnetic


Semiconductors, metals, and ceramics are used today to form highly complex systems, such as integrated electronic circuits, optoelectronic devices, and magnetic and optical mass storage media. These materials form the basis of our modern computing world, and hence research into these materials is of vital importance.

Semiconductors are a traditional example of these types of materials. They are materials that have properties that are intermediate between conductors and insulators. Their electrical conductivities are very sensitive to impurity concentrations, and this allows for the use of doping to achieve desirable electronic properties. Hence, semiconductors form the basis of the traditional computer.

This field also includes new areas of research such as superconducting materials, spintronics, metamaterials, etc. The study of these materials involves knowledge of materials science and solid-state physics or condensed matter physics.

Computational science and theory

With the increase in computing power, simulating the behavior of materials has become possible. This enables materials scientists to discover properties of materials formerly unknown, as well as to design new materials. Up until now, new materials were found by time-consuming trial and error processes. But, now it is hoped that computational methods could drastically reduce that time, and allow tailoring materials properties. This involves simulating materials at all length scales, using methods such as density functional theory, molecular dynamics, etc.

In industry

Radical materials advances can drive the creation of new products or even new industries, but stable industries also employ materials scientists to make incremental improvements and troubleshoot issues with currently used materials. Industrial applications of materials science include materials design, cost-benefit tradeoffs in industrial production of materials, processing methods (casting, rolling, welding, ion implantation, crystal growth, thin-film deposition, sintering, glassblowing, etc.), and analytic methods (characterization methods such as electron microscopy, X-ray diffraction, calorimetry, nuclear microscopy (HEFIB), Rutherford backscattering, neutron diffraction, small-angle X-ray scattering (SAXS), etc.).

Besides material characterization, the material scientist or engineer also deals with extracting materials and converting them into useful forms. Thus ingot casting, foundry methods, blast furnace extraction, and electrolytic extraction are all part of the required knowledge of a materials engineer. Often the presence, absence, or variation of minute quantities of secondary elements and compounds in a bulk material will greatly affect the final properties of the materials produced. For example, steels are classified based on 1/10 and 1/100 weight percentages of the carbon and other alloying elements they contain. Thus, the extracting and purifying methods used to extract iron in a blast furnace can affect the quality of steel that is produced.

Ceramics and glasses

Si3N4 ceramic bearing parts

Another application of material science is the structures of ceramics and glass typically associated with the most brittle materials. Bonding in ceramics and glasses uses covalent and ionic-covalent types with SiO2 (silica or sand) as a fundamental building block. Ceramics are as soft as clay or as hard as stone and concrete. Usually, they are crystalline in form. Most glasses contain a metal oxide fused with silica. At high temperatures used to prepare glass, the material is a viscous liquid. The structure of glass forms into an amorphous state upon cooling. Windowpanes and eyeglasses are important examples. Fibers of glass are also available. Scratch resistant Corning Gorilla Glass is a well-known example of the application of materials science to drastically improve the properties of common components. Diamond and carbon in its graphite form are considered to be ceramics.

Engineering ceramics are known for their stiffness and stability under high temperatures, compression and electrical stress. Alumina, silicon carbide, and tungsten carbide are made from a fine powder of their constituents in a process of sintering with a binder. Hot pressing provides higher density material. Chemical vapor deposition can place a film of a ceramic on another material. Cermets are ceramic particles containing some metals. The wear resistance of tools is derived from cemented carbides with the metal phase of cobalt and nickel typically added to modify properties.

Composites

A 6 μm diameter carbon filament (running from bottom left to top right) siting atop the much larger human hair.

Filaments are commonly used for reinforcement in composite materials.

Another application of materials science in industry is making composite materials. These are structured materials composed of two or more macroscopic phases. Applications range from structural elements such as steel-reinforced concrete, to the thermal insulating tiles which play a key and integral role in NASA's Space Shuttle thermal protection system which is used to protect the surface of the shuttle from the heat of re-entry into the Earth's atmosphere. One example is reinforced Carbon-Carbon (RCC), the light gray material which withstands re-entry temperatures up to 1,510 °C (2,750 °F) and protects the Space Shuttle's wing leading edges and nose cap. RCC is a laminated composite material made from graphite rayon cloth and impregnated with a phenolic resin. After curing at high temperature in an autoclave, the laminate is pyrolized to convert the resin to carbon, impregnated with furfural alcohol in a vacuum chamber, and cured-pyrolized to convert the furfural alcohol to carbon. To provide oxidation resistance for reuse ability, the outer layers of the RCC are converted to silicon carbide.

Other examples can be seen in the "plastic" casings of television sets, cell-phones and so on. These plastic casings are usually a composite material made up of a thermoplastic matrix such as acrylonitrile butadiene styrene (ABS) in which calcium carbonate chalk, talc, glass fibers or carbon fibers have been added for added strength, bulk, or electrostatic dispersion. These additions may be termed reinforcing fibers, or dispersants, depending on their purpose.

Polymers

The repeating unit of the polymer polypropylene
 
Expanded polystyrene polymer packaging.

Polymers are chemical compounds made up of a large number of identical components linked together like chains. They are an important part of materials science. Polymers are the raw materials (the resins) used to make what are commonly called plastics and rubber. Plastics and rubber are really the final product, created after one or more polymers or additives have been added to a resin during processing, which is then shaped into a final form. Plastics which have been around, and which are in current widespread use, include polyethylene, polypropylene, polyvinyl chloride (PVC), polystyrene, nylons, polyesters, acrylics, polyurethanes, and polycarbonates and also rubbers which have been around are natural rubber, styrene-butadiene rubber, chloroprene, and butadiene rubber. Plastics are generally classified as commodity, specialty and engineering plastics.

Polyvinyl chloride (PVC) is widely used, inexpensive, and annual production quantities are large. It lends itself to a vast array of applications, from artificial leather to electrical insulation and cabling, packaging, and containers. Its fabrication and processing are simple and well-established. The versatility of PVC is due to the wide range of plasticisers and other additives that it accepts. The term "additives" in polymer science refers to the chemicals and compounds added to the polymer base to modify its material properties.

Polycarbonate would be normally considered an engineering plastic (other examples include PEEK, ABS). Such plastics are valued for their superior strengths and other special material properties. They are usually not used for disposable applications, unlike commodity plastics.

Specialty plastics are materials with unique characteristics, such as ultra-high strength, electrical conductivity, electro-fluorescence, high thermal stability, etc.

The dividing lines between the various types of plastics is not based on material but rather on their properties and applications. For example, polyethylene (PE) is a cheap, low friction polymer commonly used to make disposable bags for shopping and trash, and is considered a commodity plastic, whereas medium-density polyethylene (MDPE) is used for underground gas and water pipes, and another variety called ultra-high-molecular-weight polyethylene (UHMWPE) is an engineering plastic which is used extensively as the glide rails for industrial equipment and the low-friction socket in implanted hip joints.

Metal alloys

Wire rope made from steel alloy.

The study of metal alloys is a significant part of materials science. Of all the metallic alloys in use today, the alloys of iron (steel, stainless steel, cast iron, tool steel, alloy steels) make up the largest proportion both by quantity and commercial value. Iron alloyed with various proportions of carbon gives low, mid and high carbon steels. An iron-carbon alloy is only considered steel if the carbon level is between 0.01% and 2.00%. For the steels, the hardness and tensile strength of the steel is related to the amount of carbon present, with increasing carbon levels also leading to lower ductility and toughness. Heat treatment processes such as quenching and tempering can significantly change these properties, however. Cast Iron is defined as an iron–carbon alloy with more than 2.00% but less than 6.67% carbon. Stainless steel is defined as a regular steel alloy with greater than 10% by weight alloying content of Chromium. Nickel and Molybdenum are typically also found in stainless steels.

Other significant metallic alloys are those of aluminium, titanium, copper and magnesium. Copper alloys have been known for a long time (since the Bronze Age), while the alloys of the other three metals have been relatively recently developed. Due to the chemical reactivity of these metals, the electrolytic extraction processes required were only developed relatively recently. The alloys of aluminium, titanium and magnesium are also known and valued for their high strength-to-weight ratios and, in the case of magnesium, their ability to provide electromagnetic shielding. These materials are ideal for situations where high strength-to-weight ratios are more important than bulk cost, such as in the aerospace industry and certain automotive engineering applications.

Semiconductors

The study of semiconductors is a significant part of materials science. A semiconductor is a material that has a resistivity between a metal and insulator. Its electronic properties can be greatly altered through intentionally introducing impurities or doping. From these semiconductor materials, things such as diodes, transistors, light-emitting diodes (LEDs), and analog and digital electric circuits can be built, making them materials of interest in industry. Semiconductor devices have replaced thermionic devices (vacuum tubes) in most applications. Semiconductor devices are manufactured both as single discrete devices and as integrated circuits (ICs), which consist of a number—from a few to millions—of devices manufactured and interconnected on a single semiconductor substrate.[14]

Of all the semiconductors in use today, silicon makes up the largest portion both by quantity and commercial value. Monocrystalline silicon is used to produce wafers used in the semiconductor and electronics industry. Second to silicon, gallium arsenide (GaAs) is the second most popular semiconductor used. Due to its higher electron mobility and saturation velocity compared to silicon, it is a material of choice for high-speed electronics applications. These superior properties are compelling reasons to use GaAs circuitry in mobile phones, satellite communications, microwave point-to-point links and higher frequency radar systems. Other semiconductor materials include germanium, silicon carbide, and gallium nitride and have various applications.

Relation to other fields

Materials science evolved—starting from the 1960s—because it was recognized that to create, discover and design new materials, one had to approach it in a unified manner. Thus, materials science and engineering emerged at the intersection of various fields such as metallurgy, solid state physics, chemistry, chemical engineering, mechanical engineering and electrical engineering.

The field is inherently interdisciplinary, and the materials scientists/engineers must be aware and make use of the methods of the physicist, chemist and engineer. The field thus maintains close relationships with these fields. Also, many physicists, chemists and engineers also find themselves working in materials science.

The overlap between physics and materials science has led to the offshoot field of materials physics, which is concerned with the physical properties of materials. The approach is generally more macroscopic and applied than in condensed matter physics. See important publications in materials physics for more details on this field of study.

The field of materials science and engineering is important both from a scientific perspective, as well as from an engineering one. When discovering new materials, one encounters new phenomena that may not have been observed before. Hence, there is a lot of science to be discovered when working with materials. Materials science also provides a test for theories in condensed matter physics.

Materials are of the utmost importance for engineers, as the usage of the appropriate materials is crucial when designing systems. As a result, materials science is an increasingly important part of an engineer's education.

Emerging technologies in materials science

Emerging technology Status Potentially marginalized technologies Potential applications Related articles
Aerogel Hypothetical, experiments, diffusion, early uses[15] Traditional insulation, glass Improved insulation, insulative glass if it can be made clear, sleeves for oil pipelines, aerospace, high-heat & extreme cold applications
Amorphous metal Experiments Kevlar Armor
Conductive polymers Research, experiments, prototypes Conductors Lighter and cheaper wires, antistatic materials, organic solar cells
Femtotechnology, picotechnology Hypothetical Present nuclear New materials; nuclear weapons, power
Fullerene Experiments, diffusion Synthetic diamond and carbon nanotubes (e.g., Buckypaper) Programmable matter
Graphene Hypothetical, experiments, diffusion, early uses[16][17] Silicon-based integrated circuit Components with higher strength to weight ratios, transistors that operate at higher frequency, lower cost of display screens in mobile devices, storing hydrogen for fuel cell powered cars, filtration systems, longer-lasting and faster-charging batteries, sensors to diagnose diseases[18] Potential applications of graphene
High-temperature superconductivity Cryogenic receiver front-end (CRFE) RF and microwave filter systems for mobile phone base stations; prototypes in dry ice; Hypothetical and experiments for higher temperatures[19] Copper wire, semiconductor integral circuits No loss conductors, frictionless bearings, magnetic levitation, lossless high-capacity accumulators, electric cars, heat-free integral circuits and processors
LiTraCon Experiments, already used to make Europe Gate Glass Building skyscrapers, towers, and sculptures like Europe Gate
Metamaterials Hypothetical, experiments, diffusion[20] Classical optics Microscopes, cameras, metamaterial cloaking, cloaking devices
Metal foam Research, commercialization Hulls Space colonies, floating cities
Multi-function structures[21] Hypothetical, experiments, some prototypes, few commercial Composite materials mostly Wide range, e.g., self health monitoring, self healing material, morphing, ...
Nanomaterials: carbon nanotubes Hypothetical, experiments, diffusion, early uses[22][23] Structural steel and aluminium Stronger, lighter materials, space elevator Potential applications of carbon nanotubes, carbon fiber
Programmable matter Hypothetical, experiments[24][25] Coatings, catalysts Wide range, e.g., claytronics, synthetic biology
Quantum dots Research, experiments, prototypes[26] LCD, LED Quantum dot laser, future use as programmable matter in display technologies (TV, projection), optical data communications (high-speed data transmission), medicine (laser scalpel)
Silicene Hypothetical, research Field-effect transistors
Superalloy Research, diffusion Aluminum, titanium, composite materials Aircraft jet engines
Synthetic diamond early uses (drill bits, jewelry) Silicon transistors Electronics

Monday, July 16, 2018

Gene delivery

From Wikipedia, the free encyclopedia
 
Gene delivery is the process of introducing foreign genetic material, such as DNA or RNA, into host cells. Genetic material must reach the nucleus of the host cell to induce gene expression. Successful gene delivery requires the foreign genetic material to remain stable within the host cell and can either integrate into the genome or replicate independently of it. This requires foreign DNA to be synthesized as part of a vector, which is designed to enter the desired host cell and deliver the transgene to that cell's genome. Vectors utilized as the method for gene delivery can be divided into two categories, recombinant viruses and synthetic vectors (viral and non-viral).

In complex multicellular eukaryotes (more specifically Weissmanists), if the transgene is incorporated into the host's germline cells, the resulting host cell can pass the transgene to its progeny. If the transgene is incorporated into somatic cells, the transgene will stay with the somatic cell line, and thus its host organism.[6]

Gene delivery is a necessary step in gene therapy for the introduction or silencing of a gene to promote a therapeutic outcome in patients and also has applications in the genetic modification of crops. There are many different methods of gene delivery for various types of cells and tissues. [7]

History

Viral based vectors emerged in the 1980's as a tool for transgene expression. In 1983, Siegel described the use of viral vectors in plant transgene expression although viral manipulation via cDNA cloning was not yet available. [8] The first virus to be used as a vaccine vector was the vaccinia virus in 1984 as a way to protect chimpanzees against Hepatitis B. [9] Non-viral gene delivery was first reported on in 1943 by Avery et al. who showed cellular phenotype change via Exogenous DNA exposure. [10]

Methods

Electroporator with square wave and exponential decay waveforms for in vitro, in vivo, adherent cell and 96 well electroporation applications. Manufactured by BTX Harvard Apparatus, Holliston MA USA.

Non-viral Delivery

Non-viral based gene delivery encompasses chemical and physical delivery methods.[11] Non-viral methods of gene delivery are less likely to induce an immune response, compared to viral vectors. They are more cost-efficient and can deliver larger sizes of genetic material. A draw back of non-viral gene delivery is low efficiency.[11]

Chemical

Non-viral chemical based methods of gene delivery uses natural or synthetic compounds to form particles that facilitate the transfer of genes into cells.[12] These synthetic vectors have the ability to electrostatically bind DNA or RNA and compact the genetic information to accommodate larger genetic transfers.[13] Non-viral chemical vectors enter cells by endocytosis and can protect genetic material from degradation.[11]

Two common non-viral vectors are liposomes and polymers. Liposome-based non-viral vectors uses liposomes to facilitate gene delivery by the formation of lipoplexes. Lipoplexes are spontaneously formed when positively charged liposomes complex with negatively charged DNA.[12] Polymer-based non-viral vectors uses polymers to interact with DNA and form polyplexes.[11]

The use of engineered organic nanoparticles is another non-viral approach for gene delivery.[14]

Physical

Artificial non-viral gene delivery can be mediated by physical methods which uses force to introduce genetic material through the cell membrane.[12]

Physical methods of gene delivery include:[12]
  • Ballistic DNA injection - Gold coated DNA particles are forced into cells
  • Electroporation -Electric pulses create pores in a cell membrane to allow entry of genetic material
  • Sonoporation - Sound waves create pores in a cell membrane to allow entry of genetic material
  • Photoporation - Laser pulses create pores in a cell membrane to allow entry of genetic material
  • Magnetofection - Magnetic particles complexed with DNA and an external magnetic field concentrate nucleic acid particles into target cells
  • Hydroporation - Hydrodynamic capillary effect manipulates cell permeability

Viral Delivery

Foreign DNA being transduced into the host cell through an adenovirus vector.

Virus mediated gene delivery utilizes the ability of a virus to inject its DNA inside a host cell and takes advantage of the virus' own ability to replicate and implement their own genetic material. Transduction is the process through which DNA is injected into the host cell and inserted into its genome [needs citation]. Viruses are a particularly effective form of gene delivery because the structure of the virus prevents degradation via lysosomes of the DNA it is delivering to the nucleus of the host cell.[15] In gene therapy a gene that is intended for delivery is packaged into a replication-deficient viral particle to form a viral vector.[16] Viruses used for gene therapy to date include retrovirus, adenovirus, adeno-associated virus and herpes simplex virus. However, there are drawbacks to using viruses to deliver genes into cells. Viruses can only deliver very small pieces of DNA into the cells, it is labor-intensive and there are risks of random insertion sites, cytophathic effects and mutagenesis.[17]

Viral vector based gene delivery uses a viral vector to deliver genetic material to the host cell. This is done by using a virus that contains the desired gene and removing the part of the viruses genome that is infectious.[18] Viruses are efficient at delivering genetic material to the host cell's nucleus, which is vital for replication.[15]

RNA-based viral vectors

RNA-based viruses were developed because of the ability to transcribe directly from infectious RNA transcripts. RNA vectors are quickly expressed and expressed in the targeted form since no processing is required. Gene integration leads to long-term transgene expression but RNA-based delivery is usually transient and not permanent.[2] Some retroviral vectors include: Oncoretroviral vectors, Lentiviral vector in gene therapy, Human foamy virus[2]

DNA-based viral vectors

DNA-based viral vectors are usually longer lasting with the possibility of integrating into the genome. Some DNA-based viral vectors include: Adenoviridae, Adeno-associated virus, Herpes simplex virus[2]

Applications

Gene Therapy

Several of the methods used to facilitate gene delivery have applications for therapeutic purposes.  Gene therapy utilizes gene delivery to deliver genetic material with the goal of treating a disease or condition in the cell. Gene delivery in therapeutic settings utilizes non-immunogenic vectors capable of cell specificity that can deliver an adequate amount of transgene expression to cause the desired effect.[19]

Advances in genomics have enabled a variety of new methods and gene targets to be identified for possible applications. DNA microarrays used in a variety of next-gen sequencing can identify thousands of genes simultaneously, with analytical software looking at gene expression patterns, and orthologous genes in model species to identify function.[20] This has allowed a variety of possible vectors to be identified for use in gene therapy. As a method for creating a new class of vaccine, gene delivery has been utilized to generate a hybrid biosynthetic vector to deliver a possible vaccine. This vector overcomes traditional barriers to gene delivery by combining E. coli with a synthetic polymer to create a vector that maintains plasmid DNA while having an increased ability to avoid degradation by target cell lysosomes.

Inequality (mathematics)

From Wikipedia, the free encyclopedia https://en.wikipedia.org/wiki/Inequality...