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Tuesday, February 10, 2015

Bill Gates


From Wikipedia, the free encyclopedia

Bill Gates
Head and shoulders photo of Bill Gates
Gates in July 2014
Born William Henry Gates III
(1955-10-28) October 28, 1955 (age 59)
Seattle, Washington, US
Residence Medina, Washington, US
Alma mater Harvard University
Occupation Technology Advisor of Microsoft
Co-Chair of the Bill & Melinda Gates Foundation
CEO of Cascade Investment
Chair of Corbis
Years active 1975–present
Net worth Increase US$81.1 billion (Jan. 2015)[1]
Board member of
Microsoft
Berkshire Hathaway
Spouse(s) Melinda Gates (m. 1994)
Children Jennifer Katharine Gates
Rory John Gates
Phoebe Adele Gates
Parents William H. Gates, Sr.
Mary Maxwell Gates
Signature William H. Gates III
Website
TheGatesNotes.com

William Henry "Bill" Gates III (born October 28, 1955) is an American business magnate, philanthropist, investor, computer programmer, and inventor.[2][3][4] Gates originally established his reputation as the co-founder of Microsoft, the world’s largest PC software company, with Paul Allen. During his career at Microsoft, Gates held the positions of chairman, CEO and chief software architect, and was also the largest individual shareholder up until May 2014.[5][a] He has also authored and co-authored several books.

Today he is consistently ranked in the Forbes list of the world's wealthiest people[8] and was the wealthiest overall from 1995 to 2014—excluding a few brief periods post-2008.[1] Between 2009 and 2014 his wealth more than doubled from $40 billion to more than $82 billion.[9] Between 2013 and 2014 his wealth increased by $15 billion, or around $1.5 billion more than the entire GDP of Iceland in 2014.[10]

Gates is one of the best-known entrepreneurs of the personal computer revolution. Gates has been criticized for his business tactics, which have been considered anti-competitive, an opinion which has in some cases been upheld by numerous court rulings.[11][12] In the later stages of his career, Gates has pursued a number of philanthropic endeavors, donating large amounts of money to various charitable organizations and scientific research programs through the Bill & Melinda Gates Foundation, established in 2000.[13]

Gates stepped down as chief executive officer of Microsoft in January 2000. He remained as chairman and created the position of chief software architect for himself. In June 2006, Gates announced that he would be transitioning from full-time work at Microsoft to part-time work, and full-time work at the Bill & Melinda Gates Foundation. He gradually transferred his duties to Ray Ozzie (who has since left Microsoft), chief software architect, and Craig Mundie, chief research and strategy officer. Gates's last full-time day at Microsoft was June 27, 2008. He stepped down as chairman of Microsoft in February 2014, taking on a new post as technology advisor to support newly appointed CEO Satya Nadella.[14]

Early life

Gates was born in Seattle, Washington, in an upper-middle-class family, the son of William H. Gates, Sr.[b] and Mary Maxwell Gates. His ancestral origin includes English, German, and Scots-Irish.[15][16] His father was a prominent lawyer, and his mother served on the board of directors for First Interstate BancSystem and the United Way. Gates's maternal grandfather was JW Maxwell, a national bank president. Gates has one elder sister, Kristi (Kristianne), and one younger sister, Libby. He was the fourth of his name in his family, but was known as William Gates III or "Trey" because his father had the "II" suffix.[17] Early on in his life, Gates's parents had a law career in mind for him.[18] When Gates was young, his family regularly attended a Protestant Congregational church.[19][20][21] The family encouraged competition; one visitor reported that "it didn't matter whether it was hearts or pickleball or swimming to the dock ... there was always a reward for winning and there was always a penalty for losing".[22]

At 13, he enrolled in the Lakeside School, an exclusive preparatory school.[23] When he was in the eighth grade, the Mothers Club at the school used proceeds from Lakeside School's rummage sale to buy a Teletype Model 33 ASR terminal and a block of computer time on a General Electric (GE) computer for the school's students.[24] Gates took an interest in programming the GE system in BASIC, and was excused from math classes to pursue his interest. He wrote his first computer program on this machine: an implementation of tic-tac-toe that allowed users to play games against the computer. Gates was fascinated by the machine and how it would always execute software code perfectly. When he reflected back on that moment, he said, "There was just something neat about the machine."[25] After the Mothers Club donation was exhausted, he and other students sought time on systems including DEC PDP minicomputers. One of these systems was a PDP-10 belonging to Computer Center Corporation (CCC), which banned four Lakeside students—Gates, Paul Allen, Ric Weiland, and Kent Evans—for the summer after it caught them exploiting bugs in the operating system to obtain free computer time.[26][27]

At the end of the ban, the four students offered to find bugs in CCC's software in exchange for computer time. Rather than use the system via Teletype, Gates went to CCC's offices and studied source code for various programs that ran on the system, including programs in Fortran, Lisp, and machine language. The arrangement with CCC continued until 1970, when the company went out of business. The following year, Information Sciences, Inc. hired the four Lakeside students to write a payroll program in Cobol, providing them computer time and royalties. After his administrators became aware of his programming abilities, Gates wrote the school's computer program to schedule students in classes. He modified the code so that he was placed in classes with "a disproportionate number of interesting girls."[28] He later stated that "it was hard to tear myself away from a machine at which I could so unambiguously demonstrate success."[25] At age 17, Gates formed a venture with Allen, called Traf-O-Data, to make traffic counters based on the Intel 8008 processor.[29] In early 1973, Bill Gates served as a congressional page in the U.S. House of Representatives.[30]

Gates graduated from Lakeside School in 1973 and was a National Merit Scholar.[31] He scored 1590 out of 1600 on the SAT[32] and enrolled at Harvard College in the autumn of 1973.[33] While at Harvard, he met Steve Ballmer, who would later succeed Gates as CEO of Microsoft.[34]

The Poker Room in Currier House at Harvard University, where Gates and Allen formed Microsoft

In his sophomore year, Gates devised an algorithm for pancake sorting as a solution to one of a series of unsolved problems[35] presented in a combinatorics class by Harry Lewis, one of his professors. Gates's solution held the record as the fastest version for over thirty years;[35][36] its successor is faster by only one percent.[35] His solution was later formalized in a published paper in collaboration with Harvard computer scientist Christos Papadimitriou.[37]

Gates did not have a definite study plan while a student at Harvard[38] and spent a lot of time using the school's computers. Gates remained in contact with Paul Allen, and he joined him at Honeywell during the summer of 1974.[39] The following year saw the release of the MITS Altair 8800 based on the Intel 8080 CPU, and Gates and Allen saw this as the opportunity to start their own computer software company.[40] Gates dropped out of Harvard at this time.[41] He had talked this decision over with his parents, who were supportive of him after seeing how much Gates wanted to start a company.[38]

Microsoft

BASIC


MITS Altair 8800 Computer with 8-inch (200 mm) floppy disk system

After reading the January 1975 issue of Popular Electronics that demonstrated the Altair 8800, Gates contacted Micro Instrumentation and Telemetry Systems (MITS), the creators of the new microcomputer, to inform them that he and others were working on a BASIC interpreter for the platform.[42] In reality, Gates and Allen did not have an Altair and had not written code for it; they merely wanted to gauge MITS's interest. MITS president Ed Roberts agreed to meet them for a demo, and over the course of a few weeks they developed an Altair emulator that ran on a minicomputer, and then the BASIC interpreter. The demonstration, held at MITS's offices in Albuquerque, was a success and resulted in a deal with MITS to distribute the interpreter as Altair BASIC. Paul Allen was hired into MITS,[43] and Gates took a leave of absence from Harvard to work with Allen at MITS in Albuquerque in November 1975. They named their partnership "Micro-Soft" and had their first office located in Albuquerque.[43] Within a year, the hyphen was dropped, and on November 26, 1976, the trade name "Microsoft" was registered with the Office of the Secretary of the State of New Mexico.[43] Gates never returned to Harvard to complete his studies.

Microsoft's BASIC was popular with computer hobbyists, but Gates discovered that a pre-market copy had leaked into the community and was being widely copied and distributed. In February 1976, Gates wrote an Open Letter to Hobbyists in the MITS newsletter saying that MITS could not continue to produce, distribute, and maintain high-quality software without payment.[44] This letter was unpopular with many computer hobbyists, but Gates persisted in his belief that software developers should be able to demand payment. Microsoft became independent of MITS in late 1976, and it continued to develop programming language software for various systems.[43] The company moved from Albuquerque to its new home in Bellevue, Washington on January 1, 1979.[42]

During Microsoft's early years, all employees had broad responsibility for the company's business. Gates oversaw the business details, but continued to write code as well. In the first five years, Gates personally reviewed every line of code the company shipped, and often rewrote parts of it as he saw fit.[45]

IBM partnership

IBM approached Microsoft in July 1980 regarding its upcoming personal computer, the IBM PC.[46] The computer company first proposed that Microsoft write the BASIC interpreter. When IBM's representatives mentioned that they needed an operating system, Gates referred them to Digital Research (DRI), makers of the widely used CP/M operating system.[47] IBM's discussions with Digital Research went poorly, and they did not reach a licensing agreement. IBM representative Jack Sams mentioned the licensing difficulties during a subsequent meeting with Gates and told him to get an acceptable operating system. A few weeks later, Gates proposed using 86-DOS (QDOS), an operating system similar to CP/M that Tim Paterson of Seattle Computer Products (SCP) had made for hardware similar to the PC. Microsoft made a deal with SCP to become the exclusive licensing agent, and later the full owner, of 86-DOS. After adapting the operating system for the PC, Microsoft delivered it to IBM as PC DOS in exchange for a one-time fee of $50,000.[48]

Gates did not offer to transfer the copyright on the operating system, because he believed that other hardware vendors would clone IBM's system.[48] They did, and the sales of MS-DOS made Microsoft a major player in the industry.[49] Despite IBM's name on the operating system the press quickly identified Microsoft as being very influential on the new computer. PC Magazine asked if Gates were "the man behind the machine?",[46] and InfoWorld quoted an expert as stating "it's Gates' computer".[50] Gates oversaw Microsoft's company restructuring on June 25, 1981, which re-incorporated the company in Washington state and made Gates President of Microsoft and the Chairman of the Board.[42]

Windows

Microsoft launched its first retail version of Microsoft Windows on November 20, 1985, and in August, the company struck a deal with IBM to develop a separate operating system called OS/2.
Although the two companies successfully developed the first version of the new system, mounting creative differences caused the partnership to deteriorate.[51]

Management style


Bill Gates in January 2008

From Microsoft's founding in 1975 until 2006, Gates had primary responsibility for the company's product strategy. He aggressively broadened the company's range of products, and wherever Microsoft achieved a dominant position he vigorously defended it.[citation needed] He gained a reputation for being distant to others; as early as 1981 an industry executive complained in public that "Gates is notorious for not being reachable by phone and for not returning phone calls."[52] Another executive recalled that after he showed Gates a game and defeated him 35 of 37 times, when they met again a month later Gates "won or tied every game. He had studied the game until he solved it. That is a competitor."[53]

As an executive, Gates met regularly with Microsoft's senior managers and program managers. Firsthand accounts of these meetings describe him as verbally combative, berating managers for perceived holes in their business strategies or proposals that placed the company's long-term interests at risk.[54][55]

He has interrupted presentations with such comments "That's the stupidest thing I've ever heard!"[56] and, "Why don't you just give up your options and join the Peace Corps?"[57] The target of his outburst then had to defend the proposal in detail until, hopefully, Gates was fully convinced.[56] When subordinates appeared to be procrastinating, he was known to remark sarcastically, "I'll do it over the weekend."[58][59][60]

Gates's role at Microsoft for most of its history was primarily a management and executive role. However, he was an active software developer in the early years, particularly on the company's programming language products. He has not officially been on a development team since working on the TRS-80 Model 100,[61] but wrote code as late as 1989 that shipped in the company's products.[59] On June 15, 2006, Gates announced that he would transition out of his day-to-day role over the next two years to dedicate more time to philanthropy. He divided his responsibilities between two successors, placing Ray Ozzie in charge of day-to-day management and Craig Mundie in charge of long-term product strategy.[62]

Antitrust litigation

Gates giving his deposition at Microsoft on August 27, 1998

Many decisions that led to antitrust litigation over Microsoft's business practices have had Gates's approval. In the 1998 United States v. Microsoft case, Gates gave deposition testimony that several journalists characterized as evasive. He argued with examiner David Boies over the contextual meaning of words such as, "compete", "concerned", and "we". The judge and other observers in the court room were seen laughing at various points during the deposition.[63] BusinessWeek reported:
Early rounds of his deposition show him offering obfuscatory answers and saying 'I don't recall,' so many times that even the presiding judge had to chuckle. Worse, many of the technology chief's denials and pleas of ignorance were directly refuted by prosecutors with snippets of e-mail that Gates both sent and received.[64]
Gates later said he had simply resisted attempts by Boies to mischaracterize his words and actions. As to his demeanor during the deposition, he said, "Did I fence with Boies? ... I plead guilty. Whatever that penalty is should be levied against me: rudeness to Boies in the first degree."[65] Despite Gates' denials, the judge ruled that Microsoft had committed monopolization and tying, and blocking competition, both in violation of the Sherman Antitrust Act.[65]

Appearance in ads


Gates mugshot of his 1977 arrest in New Mexico

Gates appeared in a series of ads to promote Microsoft in 2008. The first commercial, co-starring Jerry Seinfeld, is a 90-second talk between strangers as Seinfeld walks up on a discount shoe store (Shoe Circus) in a mall and notices Gates buying shoes inside. The salesman is trying to sell Mr. Gates shoes that are a size too big. As Gates is buying the shoes, he holds up his discount card, which uses a slightly altered version of his own mugshot of his arrest in New Mexico in 1977 for a traffic violation.[66] As they are walking out of the mall, Seinfeld asks Gates if he has melded his mind to other developers, after getting a "Yes", he then asks if they are working on a way to make computers edible, again getting a "Yes". Some say that this is an homage to Seinfeld's own show about "nothing" (Seinfeld).[67] In a second commercial in the series, Gates and Seinfeld are at the home of an average family trying to fit in with normal people.[citation needed]

Post-Microsoft

Since leaving day-to-day operations at Microsoft, Gates continues his philanthropy and, among other projects, purchased the video rights to the Messenger Lectures series called The Character of Physical Law, given at Cornell University by Richard Feynman in 1964 and recorded by the BBC.
The videos are available online to the public at Microsoft's Project Tuva.[68][69] In April 2010, Gates was invited to visit and speak at the Massachusetts Institute of Technology (MIT), where he asked the students to take on the difficult problems of the world in their futures.[70][71]

According to the Bloomberg Billionaires Index, Gates was the world's highest-earning billionaire in 2013, as his fortune increased by US$15.8 billion to US$78.5 billion. As of January 2014, most of Gates’s assets are held in Cascade Investment LLC, an entity through which he owns stakes in numerous businesses, including Four Seasons Hotels and Resorts, and Corbis Corp.[72] On February 4, 2014, Gates stepped down as Chair of Microsoft to become Technology Advisor alongside Satya Nadella.[73]

In a substantial interview with Rolling Stone magazine, published in the March 27, 2014 issue, Gates provided his perspective on a range of issues, such as climate change, his charitable activities, various tech companies and people involved in them, and the state of America. In response to a question about his greatest fear when he looks 50 years into the future, Gates stated: "... there'll be some really bad things that'll happen in the next 50 or 100 years, but hopefully none of them on the scale of, say, a million people that you didn't expect to die from a pandemic, or nuclear or bioterrorism." Gates also identified innovation as the "real driver of progress" and pronounced that "America's way better today than it's ever been."[74]

Personal life


Bill and Melinda Gates, June 2009

After being named one of Good Housekeeping '​s "50 Most Eligible Bachelors" in 1985,[75] Gates married Melinda French on January 1, 1994. They have three children: daughters Jennifer Katharine (b. 1996) and Phoebe Adele (b. 2002), and son Rory John (b. 1999). The family resides in the Gateses' home, an earth-sheltered house in the side of a hill overlooking Lake Washington in Medina. According to King County public records, as of 2006 the total assessed value of the property (land and house) is $125 million, and the annual property tax is $991,000. The 66,000 sq ft (6,100 m2) estate has a 60-foot (18 m) swimming pool with an underwater music system, as well as a 2,500 sq ft (230 m2) gym and a 1,000 sq ft (93 m2) dining room.[76]

In an interview with Rolling Stone, Gates stated in regard to his faith:
The moral systems of religion, I think, are super important. We've raised our kids in a religious way; they've gone to the Catholic church that Melinda goes to and I participate in. I've been very lucky, and therefore I owe it to try and reduce the inequity in the world. And that's kind of a religious belief. I mean, it's at least a moral belief.[77]
In the same interview, Gates said: "I agree with people like Richard Dawkins that mankind felt the need for creation myths. Before we really began to understand disease and the weather and things like that, we sought false explanations for them. Now science has filled in some of the realm – not all – that religion used to fill. But the mystery and the beauty of the world is overwhelmingly amazing, and there's no scientific explanation of how it came about. To say that it was generated by random numbers, that does seem, you know, sort of an uncharitable view [laughs]. I think it makes sense to believe in God, but exactly what decision in your life you make differently because of it, I don't know."[77]

Among Gates's private acquisitions is the Codex Leicester, a collection of writings by Leonardo da Vinci, which Gates bought for $30.8 million at an auction in 1994.[78] Gates is also known as an avid reader, and the ceiling of his large home library is engraved with a quotation from The Great Gatsby.[79] He also enjoys playing bridge, tennis, and golf.[80][81]

Gates was number one on the Forbes 400 list from 1993 through to 2007 and number one on Forbes list of The World's Richest People from 1995 to 2007 and 2009. In 1999, his wealth briefly surpassed $101 billion, causing the media to call Gates a "centibillionaire".[82] Despite his wealth and extensive business travel Gates usually flew coach until 1997, when he bought a private jet.[83] Since 2000, the nominal value of his Microsoft holdings has declined due to a fall in Microsoft's stock price after the dot-com bubble burst and the multi-billion dollar donations he has made to his charitable foundations. In a May 2006 interview, Gates commented that he wished that he were not the richest man in the world because he disliked the attention it brought.[84] In March 2010, Gates was the second wealthiest person behind Carlos Slim, but regained the top position in 2013 according to the Bloomberg Billionaires List.[85][86] Carlos Slim retook the position again in June 2014.[87][88]

Gates has several investments outside Microsoft, which in 2006 paid him a salary of $616,667 and $350,000 bonus totalling $966,667.[89] He founded Corbis, a digital imaging company, in 1989. In 2004 he became a director of Berkshire Hathaway, the investment company headed by long-time friend Warren Buffett.[90]

Around the 1990s, Gates spoke at a high school about "the eleven rules of life," aimed at high school and college graduates. The rules have since been repeated in schools across the world, with the purpose of educating students on how to be successful in their future. Although the rules are commonly attributed to Gates, it is actually originally written by educator Charles Sykes in his book "Dumbing Down on Our Kids," written in 1996.[91][92]

Philanthropy


Gates with Bono, Queen Rania of Jordan, former British Prime Minister Gordon Brown, President Umaru Yar'Adua of Nigeria and others during the Annual Meeting 2008 of the World Economic Forum in Switzerland

Bill & Melinda Gates Foundation

Gates studied the work of Andrew Carnegie and John D. Rockefeller, and in 1994 sold some of his Microsoft stock to create the "William H. Gates Foundation." In 2000, Gates and his wife combined three family foundations to create the charitable "Bill & Melinda Gates Foundation," which was identified by the Funds for NGOs company in 2013 as the world's wealthiest charitable foundation, with assets reportedly valued at more than US$34.6 billion.[93] The Foundation allows benefactors to access information that shows how its money is being spent, unlike other major charitable organizations such as the Wellcome Trust.[94][95]

Gates has credited the generosity and extensive philanthropy of David Rockefeller as a major influence. Gates and his father met with Rockefeller several times, and their charity work is partly modeled on the Rockefeller family's philanthropic focus, whereby they are interested in tackling the global problems that are ignored by governments and other organizations.[96] As of 2007, Bill and Melinda Gates were the second-most generous philanthropists in America, having given over US$28 billion to charity;[97] the couple plan to eventually donate 95 percent of their wealth to charity.[98]

On August 15, 2014, Bill Gates posted a video of himself dumping a bucket of ice water on his head, after Facebook founder Mark Zuckerberg challenged him to do so, in order to raise awareness for ALS.[99]

Personal

Gates's wife urged people to learn a lesson from the philanthropic efforts of the Salwen family, which had sold its home and given away half of its value, as detailed in The Power of Half.[100] Gates and his wife invited Joan Salwen to Seattle to speak about what the family had done, and on December 9, 2010, Gates, investor Warren Buffett, and Facebook founder and CEO Mark Zuckerberg signed a commitment they called the "Gates-Buffet Giving Pledge." The pledge is a commitment by all three to donate at least half of their wealth over the course of time to charity.[101][102][103]

Gates has also provided personal donations to educational institutions. In 1999 Gates donated US$20 million to the Massachusetts Institute of Technology (MIT) for the construction of a computer laboratory named the "William H. Gates Building" that was designed by architect Frank O. Gehry. While Microsoft had previously given financial support to the institution, this was the first personal donation received from Gates.[104]

The Maxwell Dworkin Laboratory of the Harvard School of Engineering and Applied Sciences is named after the mothers of both Gates and Microsoft President Steven A. Ballmer, both of whom were students (Ballmer was a member of the School's graduating class of 1977, while Gates left his studies for Microsoft), and donated funds for the laboratory's construction.[105] Gates also donated US$6 million to the construction of the Gates Computer Science Building, completed in January 1996, on the campus of Stanford University. The building contains the Computer Science Department (CSD) and the Computer Systems Laboratory (CSL) of Stanford's Engineering department.[106]

Criticism

In 2007 the Los Angeles Times criticized the foundation for investing its assets in companies which have been accused of worsening poverty, polluting heavily, and pharmaceutical companies that do not sell into the developing world.[107] In response to press criticism, the foundation announced a review of its investments to assess social responsibility.[108] It subsequently canceled the review and stood by its policy of investing for maximum return, while using voting rights to influence company practices.[109] The Gates Millennium Scholars program has been criticized by Ernest W. Lefever for its exclusion of Caucasian students.[110] The scholarship program is administered by the United Negro College Fund.[111]

Recognition


Gates and Steve Jobs at the 5th D: All Things Digital conference (D5) in 2007

In 1987 Gates was listed as a billionaire in Forbes magazine's 400 Richest People in America issue, just days before his 32nd birthday. As the world's youngest self-made billionaire, he was worth $1.25 billion, over $900 million more than he'd been worth the year before, when he'd debuted on the list.[112]

In 2015 Government of India awarded The Padma Bhushan[113] the third highest civilian award of The Republic of India for Gates and his wife Melinda for their contribution in Social work. Time magazine named Gates one of the 100 people who most influenced the 20th century, as well as one of the 100 most influential people of 2004, 2005, and 2006. Time also collectively named Gates, his wife Melinda and U2's lead singer Bono as the 2005 Persons of the Year for their humanitarian efforts.[114] In 2006, he was voted eighth in the list of "Heroes of our time".[115] Gates was listed in the Sunday Times power list in 1999, named CEO of the year by Chief Executive Officers magazine in 1994, ranked number one in the "Top 50 Cyber Elite" by Time in 1998, ranked number two in the Upside Elite 100 in 1999 and was included in The Guardian as one of the "Top 100 influential people in media" in 2001.[116]

According to Forbes, Gates was ranked as the fourth most powerful person in the world in 2012,[117] up from fifth in 2011.[118]

In 1994, he was honored as the twentieth Distinguished Fellow of the British Computer Society. Gates has received honorary doctorates from Nyenrode Business Universiteit, Breukelen, The Netherlands, in 2000;[119] KTH Royal Institute of Technology, Stockholm, Sweden, in 2002;[120] Waseda University, Tokyo, Japan, in 2005; Tsinghua University, Beijing, China, in April 2007;[121] Harvard University in June 2007;[122] Karolinska Institutet, Stockholm, in 2007,[123] and Cambridge University in June 2009.[124] He was also made an honorary trustee of Peking University in 2007.[125]

Gates was made an honorary Knight Commander of the Order of the British Empire (KBE) by Queen Elizabeth II in 2005.[126] In November 2006, he was awarded the Placard of the Order of the Aztec Eagle, together with his wife Melinda who was awarded the Insignia of the same order, both for their philanthropic work around the world in the areas of health and education, particularly in Mexico, and specifically in the program "Un país de lectores".[127] Gates received the 2010 Bower Award for Business Leadership from The Franklin Institute for his achievements at Microsoft and his philanthropic work.[128] Also in 2010 he was honored with the Silver Buffalo Award by the Boy Scouts of America, its highest award for adults, for his service to youth.[129]

Entomologists named Bill Gates' flower fly, Eristalis gatesi, in his honor in 1997.[130]
In 2002, Bill and Melinda Gates received the Jefferson Award for Greatest Public Service Benefiting the Disadvantaged.[131]

In 2006, Gates received the James C. Morgan Global Humanitarian Award from The Tech Awards.[132]

In recognition for the foundation's philanthropic activities in India, Bill and Melinda Gates jointly received India's third highest civilian honor Padma Bhushan in 2015.[133]

Other business ventures and investments

  • Cascade Investments LLC, a private investment and holding company, incorporated in United States, is controlled by Bill Gates, and is headquartered in the city of Kirkland, Washington.
  • bgC3, a new think-tank company founded by Bill Gates.
  • Corbis, a digital image licensing and rights services company.
  • TerraPower, a nuclear reactor design company.
  • ResearchGate, a social networking site for scientists. Gates participated in a $35 million round of financing along with other investors.[134]

Books, films, and social media

Books

To date, Bill Gates has authored two books:
  • The Road Ahead, written with Microsoft executive Nathan Myhrvold and journalist Peter Rinearson, was published in November 1995. It summarized the implications of the personal computing revolution and described a future profoundly changed by the arrival of a global information superhighway.
  • Business @ the Speed of Thought was published in 1999, and discusses how business and technology are integrated, and shows how digital infrastructures and information networks can help getting an edge on the competition.

Documentaries

Feature films

Social media

In 2013, Gates became a LinkedIn Influencer.[137]

Top climate scientists admit global warming forecasts were wrong

Top climate scientists have admitted that their global warming forecasts are wrong and world is not heating at the rate they claimed it was in a key report.

Original link:  http://www.telegraph.co.uk/news/earth/environment/climatechange/10310712/Top-climate-scientists-admit-global-warming-forecasts-were-wrong.html









Power station emitting steam and smoke
The IPCC maintain that they are 95 per cent certain that global warming is caused by humans Photo: Reuters

A leaked draft of a report by the UN Intergovernmental Panel on Climate Change is understood to concede that the computer predictions for global warming and the effects of carbon emissions have been proved to be inaccurate.

The report, to be published later this month, is a six year assessment which is seen as the gospel of climate science and is cited to justify fuel taxes and subsidies for renewable energy.

The “summary for policymakers” of the report, seen by the Mail on Sunday, states that the world is warming at a rate of 0.12C per decade since 1951, compared to a prediction of 0.13C per decade in their last assessment published in 2007.

Other admission in the latest document include that forecast computers may not have taken enough notice of natural variability in the climate, therefore exaggerating the effect of increased carbon emissions on world temperatures.

The governments which fund the IPCC have tabled 1,800 questions in relation to the report.
One of the central issues is believed to be why the IPCC failed to account for the “pause” in global warming, which they admit that they did not predict in their computer models. Since 1997, world average temperatures have not shown any statistically significant increase.

The summary also shows that scientist have now discovered that between 950 and 1250 AD, before the Industrial Revolution, parts of the world were as warm for decades at a time as they are now.

Despite a 2012 draft stating that the world is at it’s warmest for 1,300 years, the latest document states: “'Surface temperature reconstructions show multi-decadal intervals during the Medieval Climate Anomaly (950-1250) that were in some regions as warm as in the late 20th Century.”

The 2007 report included predictions of a decline in Antarctic sea ice, but the latest document does not explain why this year it is at a record high.

The 2013 report states: “'Most models simulate a small decreasing trend in Antarctic sea ice extent, in contrast to the small increasing trend in observations ...

“There is low confidence in the scientific understanding of the small observed increase in Antarctic sea ice extent.'

The 2007 forecast for more intense hurricanes has also been ignored in the new document after this year was one of the quietest hurricane seasons in history.

One of the report's authors, Professor Myles Allen, the director of Oxford University's Climate Research Network, has said that people should not look to the IPCC for a “bible” on climate change.

Professor Allen, who admits “we need to look very carefully about what the IPCC does in future”, said that he could not comment on the report as it was still considered to be in its draft stages.

However, he added: “It is a complete fantasy to think that you can compile an infallible or approximately infallible report, that is just not how science works.

“It is not a bible, it is a scientific review, an assessment of the literature. Frankly both sides are seriously confused on how science works - the critics of the IPCC and the environmentalists who credit the IPCC as if it is the gospel."

Scientist were constantly revising their research to account for new data, he said.

Despite the uncertainties and contradictions, the IPCC insists that it is more confident than ever – 95 per cent certain - that global warming is mainly human’s fault.

Next week 40 of the 250 authors who contributed to the report and representatives of most of the 195 governments that fund the IPCC will hold a meeting in Stockholm to discuss the finding to discuss any issues ahead of the publication. The body has insisted that this is not a crisis meeting but a pre-planned discussion.

Scientists Are Pretty Terrified About These Last-Minute Fixes to Global Warming

The most comprehensive study to date on geoengineering says we probably shouldn't do it—at least not yet.

| Tue Feb. 10, 2015 11:00 AM EST
| Original link:  http://www.motherjones.com/environment/2015/02/scientists-geoengineering-climate-bad-idea
 

You might have heard of "geoengineering." It's the highly controversial theory that humans could slow, stop, or even reverse global warming by "hacking" the planet with epic technological feats that would alter the chemical composition of the atmosphere.

The idea has been around for a few decades, but there have been only a few actual experiments with it, most recently in 2012 when a rogue American millionaire dumped 220,000 pounds of iron sulphate into the Pacific Ocean. His goal was to create a massive, carbon-sucking plankton bloom. The effort succeeded, but was condemned by many scientists, the Canadian government, and the United Nations for violating international laws and for forging ahead with little regard for potential ecological fallout.

Every now and then, geoengineering of one kind or another gets floated by the media as a possible silver bullet if we continue to fail to make meaningful reductions to greenhouse gas emissions. But as the plankton debacle vividly illustrated, there are any number of very good reasons why the proposition never seems to get any traction. Ideas for how to do it are either too expensive, too entangled with thorny legal and geopolitical complications, too ineffective, or all of the above.
 
"We definitely don't think that we're ready to say this is something worth doing," one of the study's lead authors said.

These issues and more were laid bare today in the most comprehensive assessment of geoengineering to date, a two-volume study involving dozens of scientists that was pulled together by the National Academy of Sciences (a nongovernmental organization that produces peer-reviewed research). The reports offered a fairly damning critique of geoengineering and found that while there could be value in continuing to research the technology, it will never be a panacea for climate change, and we're definitely not ready to start using it yet.

"We definitely don't think that we're ready to say this is something worth doing," said atmospheric chemist Lynn Russell of the University of California, San Diego, a lead author on one of the report's volumes.

There are two basic categories of geoengineering, each with its own unique obstacles. The first involves pulling carbon dioxide out of the atmosphere and burying it underground, effectively reversing the man-made greenhouse gas pollution that causes global warming. (The plankton incident fits this category; the idea was that the plankton bloom would consume a bunch of CO2 and then take it to the ocean depths when the plankton died.) The second kind involves "seeding" the atmosphere with particles that would increase its reflectivity—what climate scientists call "albedo"—and send more sunlight back into space.

Before getting into the whys and wherefores of both categories, it's important to note one key finding of the study: A major risk of all geoengineering is that scientists really don't know that much about what the risks are. This is a relatively young field, Russell explained, but more importantly, it hasn't held much attention for scientists because even the most optimistic scenarios for geoengineering aren't a preferable substitute to the more familiar endeavor of reducing greenhouse gas emissions from cars, power plants, and other sources.

"As a community we've been afraid to do the research," Russell said, "because we thought it would take attention away from mitigating greenhouse gases."

On that note, this week negotiators from around the world are meeting in Geneva to make strides toward a international climate accord expected by the end of this year. And recently President Barack Obama has announced a few major initiatives—new limits on carbon dioxide and methane emissions—that should slash America's greenhouse footprint. But progress is still too slow for most climate hawks: Even the usually-optimistic United Nations climate chief admitted last week that the upcoming accord is unlikely to keep global warming within the 3.6 degree Fahrenheit limit called for by scientists and agreed to by governments.

With that in mind, Russell said, "there is an obligation to think about whether, even if climate engineering isn't a great idea, it might not be as bad as nothing."

Which brings us back to our two categories. Here's a useful rundown of the risks and rewards of each, from the report:
NAS

Note the row fourth from the bottom, about how both kinds of geoengineering should be judged; this point is key for understanding why the scientists are against rolling out geoengineering today.
The report finds that existing carbon dioxide removal proposals (like ocean iron fertilization; a process called "weathering" that chemically dissolves CO2 in the ocean; or giant machines that suck carbon directly out of the air) are too expensive to deploy widely. Even if future engineering advances were to bring those costs down, they would have to be weighed against the costs of the more straightforward route: To stop burning fossil fuels for energy. Pulling carbon back out of the atmosphere on a scale necessary to alter the global climate, the report says, is unlikely ever to be more cost-effective than not putting it there in the first place. One notable exception is reforestation, which is cost-effective and readily deployable (a study yesterday from Oxford University argued that planting trees is one of the "most promising" short-term fixes for climate change).
 
Artificially blocking sunlight would have unknown consequences for photosynthesis by plants and phytoplankton, and high concentrations of sulphate aerosols could produce acid rain, says one expert.

The outlook for albedo modification is somewhat more frightening, in part because the technology is already relatively cheap and available. China already creates an estimated 55 billion tons of artificial rain per year by "cloud seeding"—launching chemical-filled rockets into the upper atmosphere that accelerate the formation of ice crystals that cause rain. Albedo modification would work essentially the same way, using airplanes or rockets to deliver loads of sulphate aerosols into the stratosphere, where they would bounce sunlight back into space. But if the technology is straightforward, the consequences are anything but.

The aerosols fall out of the air after a matter of years, so they would need to be continually replaced. And if we continued to burn fossil fuels, ever more aerosols would be needed to offset the warming from the additional CO2. Russell said that artificially blocking sunlight would have unknown consequences for photosynthesis by plants and phytoplankton, and that high concentrations of sulphate aerosols could produce acid rain. Moreover, if we one day suddenly ceased an albedo modification program, it could cause rapid global warming as the climate adjusts to all the built-up CO2. For these reasons, the report warns that it would be "irrational and irresponsible to implement sustained albedo modification without also pursuing emissions mitigation, carbon dioxide removal, or both."

To be fair, plenty of diversity of opinion exists among scientists. One long-time proponent of geoengineering, Harvard physicist David Keith (who was not on the committee behind this report) told the Washington Post yesterday that the technology is nothing to be afraid of: "A muffler is a technological fix for the fact that the internal combustion engine is very noisy, and people don’t have a problem with mufflers," he said.

The difference in this context is that mufflers don't come with a host of unknown, potentially catastrophic side effects. Either way, the disagreement this topic inspires just between scientists gives you some indication of how far away we are from making it practically and politically feasible. Still, Russell said, we should continue to research both kinds of geoengineering, if only to be able to express what a large-scale experiment would actually look like.

"The stage we're at now is not even having enough information to make that decision," she said. "But if we did put together a serious research program, we would make a lot of advances relatively quickly."

Molecular biology


From Wikipedia, the free encyclopedia

Molecular biology /məˈlɛkjʊlər/ is the branch of biology that deals with the molecular basis of biological activity. This field overlaps with other areas of biology and chemistry, particularly genetics and biochemistry. Molecular biology chiefly concerns itself with understanding the interactions between the various systems of a cell, including the interactions between the different types of DNA, RNA and protein biosynthesis as well as learning how these interactions are regulated.
Writing in Nature in 1961, William Astbury described molecular biology as:
"...not so much a technique as an approach, an approach from the viewpoint of the so-called basic sciences with the leading idea of searching below the large-scale manifestations of classical biology for the corresponding molecular plan. It is concerned particularly with the forms of biological molecules and [...] is predominantly three-dimensional and structural—which does not mean, however, that it is merely a refinement of morphology. It must at the same time inquire into genesis and function."[1]

Relationship to other biological sciences


Schematic relationship between biochemistry, genetics and molecular biology.

Researchers in molecular biology use specific techniques native to molecular biology but increasingly combine these with techniques and ideas from genetics and biochemistry. There is not a defined line between these disciplines. The figure above is a schematic that depicts one possible view of the relationship between the fields:
  • Biochemistry is the study of the chemical substances and vital processes occurring in live organisms. Biochemists focus heavily on the role, function, and structure of biomolecules. The study of the chemistry behind biological processes and the synthesis of biologically active molecules are examples of biochemistry.
  • Genetics is the study of the effect of genetic differences on organisms. This can often be inferred by the absence of a normal component (e.g. one gene). The study of "mutants" – organisms which lack one or more functional components with respect to the so-called "wild type" or normal phenotype. Genetic interactions (epistasis) can often confound simple interpretations of such "knockout" studies.
  • Molecular biology is the study of molecular underpinnings of the processes of replication, transcription, translation, and cell function. The central dogma of molecular biology where genetic material is transcribed into RNA and then translated into protein, despite being an oversimplified picture of molecular biology, still provides a good starting point for understanding the field. This picture, however, is undergoing revision in light of emerging novel roles for RNA.
Much of the work in molecular biology is quantitative, and recently much work has been done at the interface of molecular biology and computer science in bioinformatics and computational biology. As of the early 2000s, the study of gene structure and function, molecular genetics, has been among the most prominent sub-field of molecular biology.

Increasingly many other loops of biology focus on molecules, either directly studying their interactions in their own right such as in cell biology and developmental biology, or indirectly, where the techniques of molecular biology are used to infer historical attributes of populations or species, as in fields in evolutionary biology such as population genetics and phylogenetics. There is also a long tradition of studying biomolecules "from the ground up" in biophysics.

Techniques of molecular biology

Since the late 1950s and early 1960s, molecular biologists have learned to characterize, isolate, and manipulate the molecular components of cells and organisms. These components include DNA, the repository of genetic information; RNA, a close relative of DNA whose functions range from serving as a temporary working copy of DNA to actual structural and enzymatic functions as well as a functional and structural part of the translational apparatus; and proteins, the major structural and enzymatic type of molecule in cells.

Expression cloning

One of the most basic techniques of molecular biology to study protein function is expression cloning. In this technique, DNA coding for a protein of interest is cloned (using PCR and/or restriction enzymes) into a plasmid (known as an expression vector). A vector has 3 distinctive features: an origin of replication, a multiple cloning site (MCS), and a selective marker (usually antibiotic resistance). The origin of replication will have promoter regions upstream from the replication/transcription start site.

This plasmid can be inserted into either bacterial or animal cells. Introducing DNA into bacterial cells can be done by transformation (via uptake of naked DNA), conjugation (via cell-cell contact) or by transduction (via viral vector). Introducing DNA into eukaryotic cells, such as animal cells, by physical or chemical means is called transfection. Several different transfection techniques are available, such as calcium phosphate transfection, electroporation, microinjection and liposome transfection. DNA can also be introduced into eukaryotic cells using viruses or bacteria as carriers, the latter is sometimes called bactofection and in particular uses Agrobacterium tumefaciens. The plasmid may be integrated into the genome, resulting in a stable transfection, or may remain independent of the genome, called transient transfection.

In either case, DNA coding for a protein of interest is now inside a cell, and the protein can now be expressed. A variety of systems, such as inducible promoters and specific cell-signaling factors, are available to help express the protein of interest at high levels. Large quantities of a protein can then be extracted from the bacterial or eukaryotic cell. The protein can be tested for enzymatic activity under a variety of situations, the protein may be crystallized so its tertiary structure can be studied, or, in the pharmaceutical industry, the activity of new drugs against the protein can be studied.

Polymerase chain reaction (PCR)

The polymerase chain reaction is an extremely versatile technique for copying DNA. In brief, PCR allows a specific DNA sequence to be copied or modified in predetermined ways. The reaction is extremely powerful and under perfect conditions could amplify 1 DNA molecule to become 1.07 Billion molecules in less than 2 hours. The PCR technique can be used to introduce restriction enzyme sites to ends of DNA molecules, or to mutate (change) particular bases of DNA, the latter is a method referred to as site-directed mutagenesis. PCR can also be used to determine whether a particular DNA fragment is found in a cDNA library. PCR has many variations, like reverse transcription PCR (RT-PCR) for amplification of RNA, and, more recently, quantitative PCR which allow for quantitative measurement of DNA or RNA molecules.

Gel electrophoresis

Gel electrophoresis is one of the principal tools of molecular biology. The basic principle is that DNA, RNA, and proteins can all be separated by means of an electric field and size. In agarose gel electrophoresis, DNA and RNA can be separated on the basis of size by running the DNA through an agarose gel. Proteins can be separated on the basis of size by using an SDS-PAGE gel, or on the basis of size and their electric charge by using what is known as a 2D gel electrophoresis.

Macromolecule blotting and probing

The terms northern, western and eastern blotting are derived from what initially was a molecular biology joke that played on the term Southern blotting, after the technique described by Edwin Southern for the hybridisation of blotted DNA. Patricia Thomas, developer of the RNA blot which then became known as the northern blot, actually didn't use the term.[2] Further combinations of these techniques produced such terms as southwesterns (protein-DNA hybridizations), northwesterns (to detect protein-RNA interactions) and farwesterns (protein-protein interactions), all of which are presently found in the literature.

Southern blotting

Named after its inventor, biologist Edwin Southern, the Southern blot is a method for probing for the presence of a specific DNA sequence within a DNA sample. DNA samples before or after restriction enzyme (restriction endonuclease) digestion are separated by gel electrophoresis and then transferred to a membrane by blotting via capillary action. The membrane is then exposed to a labeled DNA probe that has a complement base sequence to the sequence on the DNA of interest. Most original protocols used radioactive labels, however non-radioactive alternatives are now available. Southern blotting is less commonly used in laboratory science due to the capacity of other techniques, such as PCR, to detect specific DNA sequences from DNA samples. These blots are still used for some applications, however, such as measuring transgene copy number in transgenic mice, or in the engineering of gene knockout embryonic stem cell lines.

Northern blotting

The northern blot is used to study the expression patterns of a specific type of RNA molecule as relative comparison among a set of different samples of RNA. It is essentially a combination of denaturing RNA gel electrophoresis, and a blot. In this process RNA is separated based on size and is then transferred to a membrane that is then probed with a labeled complement of a sequence of interest. The results may be visualized through a variety of ways depending on the label used; however, most result in the revelation of bands representing the sizes of the RNA detected in sample. The intensity of these bands is related to the amount of the target RNA in the samples analyzed. The procedure is commonly used to study when and how much gene expression is occurring by measuring how much of that RNA is present in different samples. It is one of the most basic tools for determining at what time, and under what conditions, certain genes are expressed in living tissues.

Western blotting

Antibodies to most proteins can be created by injecting small amounts of the protein into an animal such as a mouse, rabbit, sheep, or donkey (polyclonal antibodies) or produced in cell culture (monoclonal antibodies). These antibodies can be used for a variety of analytical and preparative techniques.
In western blotting, proteins are first separated by size, in a thin gel sandwiched between two glass plates in a technique known as SDS-PAGE (sodium dodecyl sulfate polyacrylamide gel electrophoresis). The proteins in the gel are then transferred to a polyvinylidene fluoride (PVDF), nitrocellulose, nylon, or other support membrane. This membrane can then be probed with solutions of antibodies. Antibodies that specifically bind to the protein of interest can then be visualized by a variety of techniques, including colored products, chemiluminescence, or autoradiography. Often, the antibodies are labeled with enzymes. When a chemiluminescent substrate is exposed to the enzyme it allows detection. Using western blotting techniques allows not only detection but also quantitative analysis.

Analogous methods to western blotting can be used to directly stain specific proteins in live cells or tissue sections. However, these immunostaining methods, such as FISH, are used more often in cell biology research.

Eastern blotting

Eastern blotting technique is to detect post-translational modification of proteins.[3] Proteins blotted on to the PVDF or nitrocellulose membrane are probed for modifications using specific substrates.

Arrays

A DNA array is a collection of spots attached to a solid support such as a microscope slide where each spot contains one or more single-stranded DNA oligonucleotide fragment. Arrays make it possible to put down large quantities of very small (100 micrometre diameter) spots on a single slide. Each spot has a DNA fragment molecule that is complementary to a single DNA sequence (similar to Southern blotting). A variation of this technique allows the gene expression of an organism at a particular stage in development to be qualified (expression profiling). In this technique the RNA in a tissue is isolated and converted to labeled cDNA. This cDNA is then hybridized to the fragments on the array and visualization of the hybridization can be done. Since multiple arrays can be made with exactly the same position of fragments they are particularly useful for comparing the gene expression of two different tissues, such as a healthy and cancerous tissue. Also, one can measure what genes are expressed and how that expression changes with time or with other factors. For instance, the common baker's yeast, Saccharomyces cerevisiae, contains about 7000 genes; with a microarray, one can measure qualitatively how each gene is expressed, and how that expression changes, for example, with a change in temperature. There are many different ways to fabricate microarrays; the most common are silicon chips, microscope slides with spots of ~ 100 micrometre diameter, custom arrays, and arrays with larger spots on porous membranes (macroarrays). There can be anywhere from 100 spots to more than 10,000 on a given array.

Arrays can also be made with molecules other than DNA. For example, an antibody array can be used to determine what proteins or bacteria are present in a blood sample.

Allele-specific oligonucleotide

Allele-specific oligonucleotide (ASO) is a technique that allows detection of single base mutations without the need for PCR or gel electrophoresis. Short (20-25 nucleotides in length), labeled probes are exposed to the non-fragmented target DNA. Hybridization occurs with high specificity due to the short length of the probes and even a single base change will hinder hybridization. The target DNA is then washed and the labeled probes that didn't hybridize are removed. The target DNA is then analyzed for the presence of the probe via radioactivity or fluorescence. In this experiment, as in most molecular biology techniques, a control must be used to ensure successful experimentation. The Illumina Methylation Assay is an example of a method that takes advantage of the ASO technique to measure one base pair differences in sequence.[citation needed]

Antiquated technologies

In molecular biology, procedures and technologies are continually being developed and older technologies abandoned. For example, before the advent of DNA gel electrophoresis (agarose or polyacrylamide), the size of DNA molecules was typically determined by rate sedimentation in sucrose gradients, a slow and labor-intensive technique requiring expensive instrumentation; prior to sucrose gradients, viscometry was used.

Aside from their historical interest, it is often worth knowing about older technology, as it is occasionally useful to solve another new problem for which the newer technique is inappropriate.

History

While molecular biology was established in the 1930s, the term was coined by Warren Weaver in 1938. Weaver was the director of Natural Sciences for the Rockefeller Foundation at the time and believed that biology was about to undergo a period of significant change given recent advances in fields such as X-ray crystallography. He therefore channeled significant amounts of (Rockefeller Institute) money into biological fields.

Clinical significance

Clinical research and medical therapies arising from molecular biology are partly covered under gene therapy[citation needed]. The use of molecular biology or molecular cell biology approaches in medicine is now called molecular medicine. Molecular biology also plays important role in understanding formations, actions, regulations of various parts of cells which can be used efficiently for targeting new drugs, diagnosis of disease, physiology of the Cell.

Occam's razor

From Wikipedia, the free encyclopedia https://en.wikipedia.org/wiki/Occam%27s_razor In philosophy , Occa...