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Wednesday, February 13, 2019

Nuclear physics

From Wikipedia, the free encyclopedia

Nuclear physics is the field of physics that studies atomic nuclei and their constituents and interactions. Other forms of nuclear matter are also studied. Nuclear physics should not be confused with atomic physics, which studies the atom as a whole, including its electrons
 
Discoveries in nuclear physics have led to applications in many fields. This includes nuclear power, nuclear weapons, nuclear medicine and magnetic resonance imaging, industrial and agricultural isotopes, ion implantation in materials engineering, and radiocarbon dating in geology and archaeology. Such applications are studied in the field of nuclear engineering.

Particle physics evolved out of nuclear physics and the two fields are typically taught in close association. Nuclear astrophysics, the application of nuclear physics to astrophysics, is crucial in explaining the inner workings of stars and the origin of the chemical elements.

History

Since 1920s cloud chambers played an important role of particle detectors and eventually lead to the discovery of positron, muon and kaon.
 
The history of nuclear physics as a discipline distinct from atomic physics starts with the discovery of radioactivity by Henri Becquerel in 1896, while investigating phosphorescence in uranium salts. The discovery of the electron by J. J. Thomson a year later was an indication that the atom had internal structure. At the beginning of the 20th century the accepted model of the atom was J. J. Thomson's "plum pudding" model in which the atom was a positively charged ball with smaller negatively charged electrons embedded inside it. 

In the years that followed, radioactivity was extensively investigated, notably by Marie and Pierre Curie as well as by Ernest Rutherford and his collaborators. By the turn of the century physicists had also discovered three types of radiation emanating from atoms, which they named alpha, beta, and gamma radiation. Experiments by Otto Hahn in 1911 and by James Chadwick in 1914 discovered that the beta decay spectrum was continuous rather than discrete. That is, electrons were ejected from the atom with a continuous range of energies, rather than the discrete amounts of energy that were observed in gamma and alpha decays. This was a problem for nuclear physics at the time, because it seemed to indicate that energy was not conserved in these decays. 

The 1903 Nobel Prize in Physics was awarded jointly to Becquerel for his discovery and to Marie and Pierre Curie for their subsequent research into radioactivity. Rutherford was awarded the Nobel Prize in Chemistry in 1908 for his "investigations into the disintegration of the elements and the chemistry of radioactive substances". 

In 1905 Albert Einstein formulated the idea of mass–energy equivalence. While the work on radioactivity by Becquerel and Marie Curie predates this, an explanation of the source of the energy of radioactivity would have to wait for the discovery that the nucleus itself was composed of smaller constituents, the nucleons.

Rutherford's team discovers the nucleus

In 1906 Ernest Rutherford published "Retardation of the α Particle from Radium in passing through matter." Hans Geiger expanded on this work in a communication to the Royal Society with experiments he and Rutherford had done, passing alpha particles through air, aluminum foil and gold leaf. More work was published in 1909 by Geiger and Ernest Marsden, and further greatly expanded work was published in 1910 by Geiger. In 1911–1912 Rutherford went before the Royal Society to explain the experiments and propound the new theory of the atomic nucleus as we now understand it.

The key experiment behind this announcement was performed in 1910 at the University of Manchester: Ernest Rutherford's team performed a remarkable experiment in which Geiger and Marsden under Rutherford's supervision fired alpha particles (helium nuclei) at a thin film of gold foil. The plum pudding model had predicted that the alpha particles should come out of the foil with their trajectories being at most slightly bent. But Rutherford instructed his team to look for something that shocked him to observe: a few particles were scattered through large angles, even completely backwards in some cases. He likened it to firing a bullet at tissue paper and having it bounce off. The discovery, with Rutherford's analysis of the data in 1911, led to the Rutherford model of the atom, in which the atom had a very small, very dense nucleus containing most of its mass, and consisting of heavy positively charged particles with embedded electrons in order to balance out the charge (since the neutron was unknown). As an example, in this model (which is not the modern one) nitrogen-14 consisted of a nucleus with 14 protons and 7 electrons (21 total particles) and the nucleus was surrounded by 7 more orbiting electrons. 

Around 1920, Arthur Eddington anticipated the discovery and mechanism of nuclear fusion processes in stars, in his paper The Internal Constitution of the Stars. At that time, the source of stellar energy was a complete mystery; Eddington correctly speculated that the source was fusion of hydrogen into helium, liberating enormous energy according to Einstein's equation E = mc2. This was a particularly remarkable development since at that time fusion and thermonuclear energy, and even that stars are largely composed of hydrogen, had not yet been discovered.

The Rutherford model worked quite well until studies of nuclear spin were carried out by Franco Rasetti at the California Institute of Technology in 1929. By 1925 it was known that protons and electrons each had a spin of ​+/-12. In the Rutherford model of nitrogen-14, 20 of the total 21 nuclear particles should have paired up to cancel each other's spin, and the final odd particle should have left the nucleus with a net spin of ​12. Rasetti discovered, however, that nitrogen-14 had a spin of 1.

James Chadwick discovers the neutron

In 1932 Chadwick realized that radiation that had been observed by Walther Bothe, Herbert Becker, Irène and Frédéric Joliot-Curie was actually due to a neutral particle of about the same mass as the proton, that he called the neutron (following a suggestion from Rutherford about the need for such a particle). In the same year Dmitri Ivanenko suggested that there were no electrons in the nucleus — only protons and neutrons — and that neutrons were spin ​12 particles which explained the mass not due to protons. The neutron spin immediately solved the problem of the spin of nitrogen-14, as the one unpaired proton and one unpaired neutron in this model each contributed a spin of ​12 in the same direction, giving a final total spin of 1. 

With the discovery of the neutron, scientists could at last calculate what fraction of binding energy each nucleus had, by comparing the nuclear mass with that of the protons and neutrons which composed it. Differences between nuclear masses were calculated in this way. When nuclear reactions were measured, these were found to agree with Einstein's calculation of the equivalence of mass and energy to within 1% as of 1934.

Proca's equations of the massive vector boson field

Alexandru Proca was the first to develop and report the massive vector boson field equations and a theory of the mesonic field of nuclear forces. Proca's equations were known to Wolfgang Pauli who mentioned the equations in his Nobel address, and they were also known to Yukawa, Wentzel, Taketani, Sakata, Kemmer, Heitler, and Fröhlich who appreciated the content of Proca's equations for developing a theory of the atomic nuclei in Nuclear Physics.

Yukawa's meson postulated to bind nuclei

In 1935 Hideki Yukawa proposed the first significant theory of the strong force to explain how the nucleus holds together. In the Yukawa interaction a virtual particle, later called a meson, mediated a force between all nucleons, including protons and neutrons. This force explained why nuclei did not disintegrate under the influence of proton repulsion, and it also gave an explanation of why the attractive strong force had a more limited range than the electromagnetic repulsion between protons. Later, the discovery of the pi meson showed it to have the properties of Yukawa's particle. 

With Yukawa's papers, the modern model of the atom was complete. The center of the atom contains a tight ball of neutrons and protons, which is held together by the strong nuclear force, unless it is too large. Unstable nuclei may undergo alpha decay, in which they emit an energetic helium nucleus, or beta decay, in which they eject an electron (or positron). After one of these decays the resultant nucleus may be left in an excited state, and in this case it decays to its ground state by emitting high energy photons (gamma decay). 

The study of the strong and weak nuclear forces (the latter explained by Enrico Fermi via Fermi's interaction in 1934) led physicists to collide nuclei and electrons at ever higher energies. This research became the science of particle physics, the crown jewel of which is the standard model of particle physics which describes the strong, weak, and electromagnetic forces.

Modern nuclear physics

A heavy nucleus can contain hundreds of nucleons. This means that with some approximation it can be treated as a classical system, rather than a quantum-mechanical one. In the resulting liquid-drop model, the nucleus has an energy which arises partly from surface tension and partly from electrical repulsion of the protons. The liquid-drop model is able to reproduce many features of nuclei, including the general trend of binding energy with respect to mass number, as well as the phenomenon of nuclear fission.

Superimposed on this classical picture, however, are quantum-mechanical effects, which can be described using the nuclear shell model, developed in large part by Maria Goeppert Mayer and J. Hans D. Jensen. Nuclei with certain numbers of neutrons and protons (the magic numbers 2, 8, 20, 28, 50, 82, 126, ...) are particularly stable, because their shells are filled. 

Other more complicated models for the nucleus have also been proposed, such as the interacting boson model, in which pairs of neutrons and protons interact as bosons, analogously to Cooper pairs of electrons. 

Ab initio methods try to solve the nuclear many-body problem from the ground up, starting from the nucleons and their interactions.

Much of current research in nuclear physics relates to the study of nuclei under extreme conditions such as high spin and excitation energy. Nuclei may also have extreme shapes (similar to that of Rugby balls or even pears) or extreme neutron-to-proton ratios. Experimenters can create such nuclei using artificially induced fusion or nucleon transfer reactions, employing ion beams from an accelerator. Beams with even higher energies can be used to create nuclei at very high temperatures, and there are signs that these experiments have produced a phase transition from normal nuclear matter to a new state, the quark–gluon plasma, in which the quarks mingle with one another, rather than being segregated in triplets as they are in neutrons and protons.

Nuclear decay

Eighty elements have at least one stable isotope which is never observed to decay, amounting to a total of about 254 stable isotopes. However, thousands of isotopes have been characterized as unstable. These "radioisotopes" decay over time scales ranging from fractions of a second to trillions of years. Plotted on a chart as a function of atomic and neutron numbers, the binding energy of the nuclides forms what is known as the valley of stability. Stable nuclides lie along the bottom of this energy valley, while increasingly unstable nuclides lie up the valley walls, that is, have weaker binding energy. 

The most stable nuclei fall within certain ranges or balances of composition of neutrons and protons: too few or too many neutrons (in relation to the number of protons) will cause it to decay. For example, in beta decay a nitrogen-16 atom (7 protons, 9 neutrons) is converted to an oxygen-16 atom (8 protons, 8 neutrons) within a few seconds of being created. In this decay a neutron in the nitrogen nucleus is converted by the weak interaction into a proton, an electron and an antineutrino. The element is transmuted to another element, with a different number of protons. 

In alpha decay (which typically occurs in the heaviest nuclei) the radioactive element decays by emitting a helium nucleus (2 protons and 2 neutrons), giving another element, plus helium-4. In many cases this process continues through several steps of this kind, including other types of decays (usually beta decay) until a stable element is formed. 

In gamma decay, a nucleus decays from an excited state into a lower energy state, by emitting a gamma ray. The element is not changed to another element in the process (no nuclear transmutation is involved). 

Other more exotic decays are possible (see the first main article). For example, in internal conversion decay, the energy from an excited nucleus may eject one of the inner orbital electrons from the atom, in a process which produces high speed electrons, but is not beta decay, and (unlike beta decay) does not transmute one element to another.

Nuclear fusion

In nuclear fusion, two low mass nuclei come into very close contact with each other, so that the strong force fuses them. It requires a large amount of energy for the strong or nuclear forces to overcome the electrical repulsion between the nuclei in order to fuse them; therefore nuclear fusion can only take place at very high temperatures or high pressures. When nuclei fuse, a very large amount of energy is released and the combined nucleus assumes a lower energy level. The binding energy per nucleon increases with mass number up to nickel-62. Stars like the Sun are powered by the fusion of four protons into a helium nucleus, two positrons, and two neutrinos. The uncontrolled fusion of hydrogen into helium is known as thermonuclear runaway. A frontier in current research at various institutions, for example the Joint European Torus (JET) and ITER, is the development of an economically viable method of using energy from a controlled fusion reaction. Nuclear fusion is the origin of the energy (including in the form of light and other electromagnetic radiation) produced by the core of all stars including our own Sun.

Nuclear fission

Nuclear fission is the reverse process to fusion. For nuclei heavier than nickel-62 the binding energy per nucleon decreases with the mass number. It is therefore possible for energy to be released if a heavy nucleus breaks apart into two lighter ones. 

The process of alpha decay is in essence a special type of spontaneous nuclear fission. It is a highly asymmetrical fission because the four particles which make up the alpha particle are especially tightly bound to each other, making production of this nucleus in fission particularly likely. 

From certain of the heaviest nuclei whose fission produces free neutrons, and which also easily absorb neutrons to initiate fission, a self-igniting type of neutron-initiated fission can be obtained, in a chain reaction. Chain reactions were known in chemistry before physics, and in fact many familiar processes like fires and chemical explosions are chemical chain reactions. The fission or "nuclear" chain-reaction, using fission-produced neutrons, is the source of energy for nuclear power plants and fission type nuclear bombs, such as those detonated in Hiroshima and Nagasaki, Japan, at the end of World War II. Heavy nuclei such as uranium and thorium may also undergo spontaneous fission, but they are much more likely to undergo decay by alpha decay.

For a neutron-initiated chain reaction to occur, there must be a critical mass of the relevant isotope present in a certain space under certain conditions. The conditions for the smallest critical mass require the conservation of the emitted neutrons and also their slowing or moderation so that there is a greater cross-section or probability of them initiating another fission. In two regions of Oklo, Gabon, Africa, natural nuclear fission reactors were active over 1.5 billion years ago.[24] Measurements of natural neutrino emission have demonstrated that around half of the heat emanating from the Earth's core results from radioactive decay. However, it is not known if any of this results from fission chain reactions.

Production of "heavy" elements

According to the theory, as the Universe cooled after the Big Bang it eventually became possible for common subatomic particles as we know them (neutrons, protons and electrons) to exist. The most common particles created in the Big Bang which are still easily observable to us today were protons and electrons (in equal numbers). The protons would eventually form hydrogen atoms. Almost all the neutrons created in the Big Bang were absorbed into helium-4 in the first three minutes after the Big Bang, and this helium accounts for most of the helium in the universe today. 

Some relatively small quantities of elements beyond helium (lithium, beryllium, and perhaps some boron) were created in the Big Bang, as the protons and neutrons collided with each other, but all of the "heavier elements" (carbon, element number 6, and elements of greater atomic number) that we see today, were created inside stars during a series of fusion stages, such as the proton-proton chain, the CNO cycle and the triple-alpha process. Progressively heavier elements are created during the evolution of a star. 

Since the binding energy per nucleon peaks around iron (56 nucleons), energy is only released in fusion processes involving smaller atoms than that. Since the creation of heavier nuclei by fusion requires energy, nature resorts to the process of neutron capture. Neutrons (due to their lack of charge) are readily absorbed by a nucleus. The heavy elements are created by either a slow neutron capture process (the so-called s-process) or the rapid, or r-process. The s process occurs in thermally pulsing stars (called AGB, or asymptotic giant branch stars) and takes hundreds to thousands of years to reach the heaviest elements of lead and bismuth. The r-process is thought to occur in supernova explosions which provide the necessary conditions of high temperature, high neutron flux and ejected matter. These stellar conditions make the successive neutron captures very fast, involving very neutron-rich species which then beta-decay to heavier elements, especially at the so-called waiting points that correspond to more stable nuclides with closed neutron shells (magic numbers).

Pro-nuclear movement

From Wikipedia, the free encyclopedia

Patrick Moore (environmentalist) in 2009. Moore was opposed to nuclear power in the 1970s  but has since come to be in favor of it. Moore is supported by the Nuclear Energy Institute (NEI) and in 2009 he chaired their Clean and Safe Energy Coalition. As chair, he suggested that the public is not as opposed to nuclear energy as they were in decades past.

There are large variations in peoples’ understanding of the issues surrounding nuclear power, including the technology itself, climate change, and energy security. Proponents of nuclear energy contend that nuclear power is a sustainable energy source that reduces carbon emissions and increases energy security by decreasing dependence on imported energy sources. Opponents believe that nuclear power poses many threats to people and the environment.

While nuclear power has historically been opposed by many environmentalist organisations, some support it. In addition, besides organizations, some scientists also support it.

Context

During a two-day symposium on "Atomic Power in Australia" at the New South Wales University of Technology, Sydney, which began on 31 August 1954, Professors Marcus Oliphant (left), Homi Jehangir Bhabha (centre) and Philip Baxter, share a cup of tea
 
Nuclear energy remains a controversial area of public policy. The debate about nuclear power peaked during the 1970s and 1980s, when it "reached an intensity unprecedented in the history of technology controversies", in some countries.

Proponents of nuclear energy point to the fact nuclear power produces virtually no conventional air pollution, greenhouse gases, and smog, in contrast to fossil fuel sources of energy. Proponents argue perceived risks of storing waste are exaggerated, and point to an operational safety record in the Western world which is excellent in comparison to the other major kinds of power plants. Historically, there have been numerous proponents of nuclear energy, including Georges Charpak, Glenn T. Seaborg, Edward Teller, Alvin M. Weinberg, Eugene Wigner, Ted Taylor (physicist), and Jeff Eerkens. There are also scientists who write favorably about nuclear energy in terms of the broader energy landscape, including Robert B. Laughlin, Michael McElroy (scientist), and Vaclav Smil. In particular, Laughlin writes in "Powering the Future" (2011) that expanded use of nuclear power will be nearly inevitable, either because of a political choice to leave fossil fuels in the ground, or because fossil fuels become depleted.

Lobbying and public relations activities

Globally, there are dozens of companies with an interest in the nuclear industry, including Areva, BHP Billiton, Cameco, China National Nuclear Corporation, EDF, Iberdrola, Nuclear Power Corporation of India, Ontario Power Generation, Rosatom, TEPCO, and Vattenfall. Many of these companies lobby politicians and others about nuclear power expansion, undertake public relation activities, petition government authorities, as well as influence public policy through referendum campaigns and involvement in elections.

The nuclear industry has "tried a variety of strategies to persuade the public to accept nuclear power", including the publication of numerous "fact sheets" that discuss issues of public concern. Nuclear proponents have worked to boost public support by offering newer, safer, reactor designs. These designs include those that incorporate passive safety and Small Modular Reactors

Since 2000 the nuclear industry has undertaken an international media and lobbying campaign to promote nuclear power as a solution to the greenhouse effect and climate change. Though reactor operation is free of carbon dioxide emissions, other stages of the nuclear fuel chain – from uranium mining, to reactor decommissioning and radioactive waste management – use fossil fuels and hence emit carbon dioxide. 

The Nuclear Energy Institute has formed various sub-groups to promote nuclear power. These include the Washington-based Clean and Safe Energy Coalition, which was formed in 2006 and led by Patrick Moore. Christine Todd Whitman, former head of the USEPA has also been involved. Clean Energy America is another group also sponsored by the NEI.

In Britain, James Lovelock well known for his Gaia Hypothesis began to support nuclear power in 2004. He is patron of the Supporters of Nuclear Energy. SONE also campaigns against wind power. The main nuclear lobby group in Britain is FORATOM.

As of 2014, the U.S. nuclear industry has begun a new lobbying effort, hiring three former senators — Evan Bayh, a Democrat; Judd Gregg, a Republican; and Spencer Abraham, a Republican — as well as William M. Daley, a former staffer to President Obama. The initiative is called Nuclear Matters, and it has begun a newspaper advertising campaign.

Organizations supporting nuclear power

In March 2017, a bipartisan group of eight senators, including five Republicans and three Democrats introduced S. 512, the Nuclear Energy Innovation and Modernization Act (NEIMA). The legislation would help to modernize the Nuclear Regulatory Commission (NRC), support the advancement of the nation's nuclear industry and develop the regulatory framework to enable the licensing of advanced nuclear reactors, while improving the efficiency of uranium regulation. Letters of support for this legislation were provided by thirty-six organizations, including for profit enterprises, non-profit organizations and educational institutions. The most prominent entities from that group and other well-known organizations actively supporting the continued or expanded use of nuclear power as a solution for providing clean, reliable energy include:
The United States generates about 19% of its electricity from nuclear power plants. Nearly 60% of all clean energy generated in the U.S. comes from nuclear power. Studies have shown that closing a nuclear power plant results in greatly increased carbon emissions as only burning coal or natural gas can make up for the massive amount of energy lost from a nuclear power plant. Even though there have long been protests against nuclear power, the effect of long-term scrutiny has elevated safety within the industry, making nuclear power the safest form of energy in operation today, despite the fact that many continue to fear it. Nuclear power plants create thousands of jobs, many in health and safety jobs, and seldom experience protests from area residents, as they bring large amounts of economic activity, attract educated employees and leave the air clear safe, unlike oil, coal or gas plants, which bring disease and environmental damage to their workers and neighbors. Nuclear engineers have traditionally worked, directly or indirectly, in the nuclear power industry, in academia or for national laboratories. More recently, young nuclear engineers have started to innovate and launch new companies, becoming entrepreneurs in order to bring their enthusiasm for using the power of the atom to address the climate crisis. As of June 2015, Third Way released a report identifying 48 nuclear start-ups or projects organized to work on nuclear innovations in what is being called "advanced nuclear" designs. Current research in the industry is directed at producing economical, proliferation-resistant reactor designs with passive safety features. Although government labs research the same areas as industry, they also study a myriad of other issues such as nuclear fuels and nuclear fuel cycles, advanced reactor designs, and nuclear weapon design and maintenance. A principal pipeline for trained personnel for US reactor facilities is the Navy Nuclear Power Program. The job outlook for nuclear engineering from the year 2012 to the year 2022 is predicted to grow 9% due to many elder nuclear engineers retiring, safety systems needing to be updated in power plants, and the advancements made in nuclear medicine.

Individuals supporting nuclear power

Many people, including former opponents of nuclear energy, now say that nuclear energy is necessary for reducing carbon dioxide emissions. They recognize that the threat to humanity from climate change is far worse than any risk associated with nuclear energy. Many of these supporters, but not all, acknowledge that renewable energy is also important to the effort to eliminate emissions. Early environmentalists who publicly voiced support for nuclear power include James Lovelock, originator of the Gaia hypothesis, Patrick Moore, a co-founder of Greenpeace and former director of Greenpeace International, George Monbiot and Stewart Brand, creator of the Whole Earth Catalog. Lovelock goes further to refute claims about the danger of nuclear energy and its waste products. In a January 2008 interview, Moore said that "It wasn't until after I'd left Greenpeace and the climate change issue started coming to the forefront that I started rethinking energy policy in general and realised that I had been incorrect in my analysis of nuclear as being some kind of evil plot." There are increasing numbers of scientists and laymen who are environmentalists with views that depart from the mainstream environmental stance that rejects a role for nuclear power in the climate fight (once labelled "Nuclear Greens," some now consider themselves Ecomodernists). Some of these include:

Scientists

Non-scientists

Open letter signatories
Climate and energy scientists in 2013: there is no credible path to climate stabilization that does not include a substantial role for nuclear power
Conservation biologists in 2014: to replace the burning of fossil fuels, if we are to have any chance of mitigating severe climate change […we] need to accept a substantial role for advanced nuclear power systems with complete fuel recycling

The following is a list of people that signed the open letter:

Future prospects

The International Thermonuclear Experimental Reactor, located in France, is the world's largest and most advanced experimental tokamak nuclear fusion reactor project. A collaboration between the European Union (EU), India, Japan, China, Russia, South Korea and the United States, the project aims to make a transition from experimental studies of plasma physics to electricity-producing fusion power plants. However, the World Nuclear Association says that nuclear fusion "presents so far insurmountable scientific and engineering challenges". Construction of the ITER facility began in 2007, but the project has run into many delays and budget overruns. The facility is now not expected to begin operations until the year 2027 – 11 years after initially anticipated.

Uncovering the Evolution of the Brain


Summary: Researchers have developed a new technique to study the development of human neurons compared to the neurons of nonhuman primates. The findings shed new light on the evolution of the human brain.

Source: Salk Institute.

What makes us human, and where does this mysterious property of “humanness” come from? Humans are genetically similar to chimpanzees and bonobos, yet there exist obvious behavioral and cognitive differences. Now, researchers from the Salk Institute, in collaboration with researchers from the anthropology department at UC San Diego, have developed a strategy to more easily study the early development of human neurons compared with the neurons of nonhuman primates. The study, which appeared in eLife on February 7, 2019, offers scientists a novel tool for fundamental brain research.

“This study provides insights into the developmental organization of the brain and lays the groundwork for further comparative analyses between humans and nonhuman primates,” says one of the senior authors of the study, Salk President and Professor Rusty Gage, who holds the Vi and John Adler Chair for Research on Age-Related Neurodegenerative Disease.

Two important processes in brain development include neuron maturation and migration. Maturation involves neuron growth as the neurons increase their connections between each other for better communication. Migration is the physical movement of neurons into different parts of the developing brain. The authors sought to compare neuron maturation and migration between humans and nonhuman primates.
To accomplish this task, the Gage lab devised a new method utilizing stem cell technology to take skin cells from primates and coax them, via a virus and chemical cocktails, to develop into neural progenitor cells, a cell type that has the ability to become multiple types of cells in the brain, including neurons. These new primate cell lines can then be perpetually propagated, allowing researchers new avenues to study aspects of neuronal development of live neurons without tissue samples from endangered primates such as chimpanzees and bonobos.

“This is a novel strategy to study human evolution,” says Carol Marchetto, a Salk senior staff scientist in the Laboratory of Genetics, co-first author and one of the study’s senior authors. “We are happy to share these primate cell lines with the scientific community, so that researchers from around the world can examine primate brain development without the use of tissue samples. We anticipate this will lead to numerous new findings over the next few years about the brain’s evolution.”
The researchers first explored the differences in gene expression related to neuronal movement, comparing human, chimpanzee and bonobo cells. They also investigated the migration properties of the neurons inherent to each species. They found 52 genes related to migration, and, interestingly, chimpanzee and bonobo neurons had periods of rapid migration, while human neurons were slow to move.

In order to compare neuron movement and maturation outside of a dish, the scientists transplanted the neural progenitor cells from both humans and chimpanzees into the brains of rodents, enabling the neurons to thrive and providing additional developmental cues for the neurons to develop.

The researchers then analyzed the differences in migration distance, shape and size of the neurons for up to 19 weeks after transplantation. They observed the length, density and quantity of extensions of the neurons called dendrites, as well as the size of the cell bodies, which house the nucleus and DNA.

pyramidal neurons
A stylized microscopy image of forebrain neural progenitor cells from chimpanzees described in the publication. The image represents the work’s potential for offering insights into the evolution of the primate tree of life. NeuroscienceNews.com image is credited to Salk Institute/Carol Marchetto/Ana P.D. Mendes.

The chimpanzee neurons migrated a greater distance and covered a 76 percent greater area than the human neurons after two weeks. Human neurons were slower to develop but reached longer lengths than the chimpanzee neurons. This slower growth pattern may allow humans to reach more developmental milestones than nonhuman primates, which could account for differences in behavior and cognitive abilities.

In the future, the authors hope to construct an evolutionary tree of multiple primate species, utilizing induced pluripotent stem cell lines, to better understand of the evolution of the human brain. In addition, the authors plan to use this platform to study gene regulation differences between primate species that underlie the differences in neuronal maturation and can potentially impact brain organization in humans.

“We have limited knowledge about the evolution of the brain, especially when it comes to differences in cellular development between species,” says Marchetto. “We’re excited about the tremendous possibilities this work opens up for the field of neuroscience and brain evolution.”
 
About this neuroscience research article

Other researchers on the study were Krishna Vadodaria, Sara B. Linker, Inigo Narvaiza, Renata Santos, Ahmet M. Denli, Ana P.D. Mendes, Ruth Oefner, Jonathan Cook, Lauren McHenry, Jaeson M Grasmick, Kelly Heard, Callie Fredlender, Lynne Randolph-Moore, Rijul Kshirsagar, Rea Xenitopoulos, Grace Chou and Nasun Hah from the Salk Institute for Biological Studies; Branka Hrvoj-Mihic, Katerina Semendeferi and Alysson R. Muotri from the University of California San Diego; Bilal E. Kerman from at Istanbul Medipol University; Diana X. Yu from the University of Utah; and Krishnan Padmanabhan from the University of Rochester.

Funding: The work and the researchers involved were supported by grants from the National Institutes of Health, the Leona M. and Harry B. Helmsley Charitable Trust, the California Institute for Regenerative Medicine and the Brain and Behavior Research Foundation (formerly the National Alliance for Research on Schizophrenia and Depression).

Source: Salk Institute

Publisher: Organized by NeuroscienceNews.com.
Image Source: NeuroscienceNews.com image is credited to Salk Institute/Carol Marchetto/Ana P.D. Mendes.
Original Research: Open access research for “Species-specific maturation profiles of human, chimpanzee and bonobo neural cells” by Maria C Marchetto, Branka Hrvoj-Mihic, Bilal E Kerman, Diana X Yu, Krishna C Vadodaria, Sara B Linker, Iñigo Narvaiza, Renata Santos, Ahmet M Denli, Ana PD Mendes, Ruth Oefner, Jonathan Cook, Lauren McHenry, Jaeson M Grasmick, Kelly Heard, Callie Fredlender, Lynne Randolph-Moore, Rijul Kshirsagar, Rea Xenitopoulos, Grace Chou, Nasun Hah, Alysson R Muotri, Krishnan Padmanabhan, Katerina Semendeferi, and Fred H Gage in eLife. Published February 7 2019.
doi:10.7554/eLife.37527

Occam's razor

From Wikipedia, the free encyclopedia https://en.wikipedia.org/wiki/Occam%27s_razor In philosophy , Occa...