Sex differences in humans have been studied in a variety of fields. In humans, biological sex is determined by five factors present at birth: the presence or absence of a Y chromosome, the type of gonads, the sex hormones, the internal reproductive anatomy (such as the uterus), and the external genitalia. Genetic sex is determined solely by the presence or absence of a Y chromosome. Phenotypic sex refers to an individual's sex as determined by their internal and external genitalia, expression of secondary sex characteristics, and behavior.
The sex of the individual can be defined in different ways, giving rise to different conceptual frameworks about what determines sex. Sex differences generally refer to traits that are sexually dimorphic. A subset of such differences is hypothesized to be the product of the evolutionary process of sexual selection.
Medicine
Sex differences in medicine include sex-specific diseases, which are diseases that occur only in people of one sex;
 and sex-related diseases, which are diseases that are more usual to one
 sex, or which manifest differently in each sex. For example, certain autoimmune diseases may occur predominantly in one sex, for unknown reasons. 90% of primary biliary cirrhosis cases are women, whereas primary sclerosing cholangitis
 is more common in men. Gender-based medicine, also called "gender 
medicine", is the field of medicine that studies the biological and 
physiological differences between the human sexes and how that affects 
differences in disease. Traditionally, medical research has mostly been 
conducted using the male body as the basis for clinical studies. Similar
 findings are also reported in the sport medicine literature where males
 typically account for >60% of the individuals studied.
 The findings of these studies have often been applied across the sexes 
and healthcare providers have assumed a uniform approach in treating 
both male and female patients. More recently, medical research has 
started to understand the importance of taking the sex into account as 
the symptoms and responses to medical treatment may be very different 
between sexes.
Neither concept should be confused with sexually transmitted diseases, which are diseases that have a significant probability of transmission through sexual contact.
Sex-related illnesses have various causes:
- Sex-linked genetic illnesses
 - Parts of the reproductive system that are specific to one sex
 - Social causes that relate to the gender role expected of that sex in a particular society.
 - Different levels of prevention, reporting, diagnosis or treatment in each gender.
 
Research has found that female doctors may be providing better care than male doctors in the U.S. and also in Canada.
Physiology
Sex differences in human physiology are distinctions of physiological
 characteristics associated with either male or female humans. These can
 be of several types, including direct and indirect, direct being the 
direct result of differences prescribed by the Y-chromosome, and 
indirect being characteristics influenced indirectly (e.g., hormonally) 
by the Y-chromosome. Sexual dimorphism is a term for the phenotypic difference between males and females of the same species.
Direct sex differences follow a bimodal distribution. Through the process of meiosis and fertilization
 (with rare exceptions), each individual is created with zero or one 
Y-chromosome. The complementary result for the X-chromosome follows, 
either a double or a single X. Therefore, direct sex differences are 
usually binary in expression (although the deviations in complex 
biological processes produce a menagerie of exceptions). These include, 
most conspicuously, male (vs female) gonads.
Indirect sex differences are general differences as quantified by empirical data and statistical analysis. Most differing characteristics will conform to a bell-curve
 (i.e., normal) distribution which can be broadly described by the mean 
(peak distribution) and standard deviation (indicator of size of range).
 Often only the mean or mean difference between sexes is given. This may
 or may not preclude overlap in distributions. For example, most males are taller and stronger than females,
 but an individual female could be taller and stronger than an 
individual male. The extents of these differences vary across societies.
The most obvious differences between males and females include 
all the features related to reproductive role, notably the endocrine 
(hormonal) systems and their physiological and behavioral effects, 
including gonadal differentiation, internal and external genital and 
breast differentiation, and differentiation of muscle mass, height, and 
hair distribution. There are also differences in the structure of 
specific areas of the brain. For example, on average, the SDN (INAH3 in humans) has been repeatedly found to be considerably larger in males than in females.
Psychology
Research on biological sex differences in human psychology investigates cognitive and behavioral differences between men and women. This research employs experimental tests of cognition, which take a variety of forms. Tests focus on possible differences in areas such as IQ, spatial reasoning, aggression, emotion, and brain structure and function. 
Chromosomal make up is important in human psychology. Women have 
two X chromosomes while males have an X and Y chromosomal structure. The
 X chromosome is much more active than Y and it affects behavior. Genetic researchers theorize that the X chromosome may contain a gene responsible for sociability.
Most IQ tests are constructed so that there are no overall score 
differences between females and males. Areas where differences have been
 found include verbal and mathematical ability. IQ tests that measure fluid g
 and have not been constructed to eliminate sex differences also tend to
 show that sex differences are either non-existent or negligible.
 2008 research found that, for grades 2 to 11, there were no significant
 gender differences in math skills among the general population. Differences in variability of IQ scores have been observed in studies, with more men falling at the extremes of the spectrum.
Because social and environmental factors affect brain activity 
and behavior, where differences are found, it can be difficult for 
researchers to assess whether or not the differences are innate.
 Studies on this topic explore the possibility of social influences on 
how both sexes perform in cognitive and behavioral tests. Stereotypes about differences between men and women have been shown to affect a person's behavior (this is called stereotype threat).
In his book titled Gender, Nature, and Nurture, 
psychologist Richard Lippa found that there were large differences in 
women's and men's preferences for realistic occupations (for example, 
mechanic or carpenters) and moderate differences in their preferences 
for social and artistic occupations. His results also found that women 
tend to be more people-oriented and men more thing-oriented.
Hartung & Widiger (1998) found that many kinds of mental 
illnesses and behavioral problems show gender differences in prevalence 
and incidence. "Of the 80 disorders diagnosed in adulthood for which sex
 ratios are provided, 35 are said to be more common in men than in women
 (17 of which are substance related or a paraphilia), 31 are said to be more common in women than men, and 14 are said to be equally common in both sexes."
Differences in male and female jealousy can also be observed. 
While female jealousy is more likely to be inspired by emotional 
infidelity, male jealousy is most likely to be brought on by sexual 
infidelity. A clear majority of approximately 62% to 86% of women 
reported that they would be more bothered by emotional infidelity and 
47% to 60% of men reported that they would be more bothered by sexual 
infidelity.
In 2005, Janet Shibley Hyde from the University of Wisconsin-Madison
 introduced the gender similarities hypothesis, which suggests that 
males and females are similar on most, but not all, psychological 
variables. The research focused on cognitive variables (for example, 
reading comprehension, mathematics), communication (for example, 
talkativeness, facial expressions), social and personality (for example,
 aggression, sexuality), psychological well-being, and motor behaviors. 
Using results from a review of 46 meta-analyses, she found that 78% of 
gender differences were small or close to zero. A few exceptions were 
some motor behaviors (such as throwing distance) and some aspects of 
sexuality (such as attitudes about casual sex), which show the largest 
gender differences. She concludes her article by stating: "It is time to
 consider the costs of overinflated claims of gender differences. 
Arguably, they cause harm in numerous realms, including women’s 
opportunities in the workplace, couple conflict and communication, and 
analyses of self-esteem problems among adolescents." Hyde also stated elsewhere that "variations within genders are greater than variations between genders."
In 2011 Irina Trofimova found a significant female advantage in 
time on the lexical task and on the temperament scale of social-verbal 
tempo, and a male advantage on the temperament scale of physical 
endurance which were more pronounced in young age groups and faded in 
older groups. She suggested that there is a "middle age - middle sex" 
effect: sex differences in these two types of abilities observed in 
younger groups might be entangled with age and hormonal changes. The 
study concluded that a one-dimensional approach to sex differences 
(common in meta-analytic studies) therefore overlooks a possible 
interaction of sex differences with age.
 This hormones-based "middle age-middle sex effect", and also specifics 
of the few psychological sex differences (verbal and physical) were 
analysed in terms of the systemic evolutional tendencies driving sex 
dimorphism. 
Sociology
Crime
Statistics have been consistent in reporting that men commit more criminal acts than women. Self-reported delinquent acts are also higher for men than women across many different actions. Many professionals have offered explanations for this sex difference. Some differing explanations include men's evolutionary tendency toward risk and violent behavior, sex differences in activity, social support, and gender inequality. 
Despite the difficulty of interpreting them, crime statistics
 may provide a way to investigate such a relationship from a gender 
differences perspective. An observable difference in crime rates between
 men and women might be due to social and cultural factors, crimes going
 unreported, or to biological factors (for example, testosterone
 or sociobiological theories). Taking the nature of the crime itself 
into consideration may also be a factor. Crime can be measured by such 
data as arrest records, imprisonment rates, and surveys. However, not 
all crimes are reported or investigated. Moreover, some studies show 
that men can have an overwhelming bias against reporting themselves to 
be the victims of a crime (particularly when victimized by a woman), and
 some studies have argued that men reporting intimate partner violence find disadvantageous biases in law enforcement.  Burton et al. (1998) found that low levels of self control are associated with criminal activity.
Education
A world map showing countries by gender education disparity, 2010.
Sometimes and in some places, there are sex differences in educational achievement. This may be caused by sex discrimination in law or culture, or may reflect natural differences in the interests of the sexes.
Leadership
Research has been undertaken to examine whether or not there are sex 
differences in leadership. Until recently, leadership positions have 
predominantly been held by men. Women were rarely seen in senior leadership positions leading to a lack of data on how they behave in such positions.
 The two main lines of research contradict one another, the first being 
that there are significant sex differences in leadership and the second 
being that gender does not have an effect on leadership.
Women and men have been surveyed by Gallup each year concerning 
workplace topics, and when questioned about preferences of a female boss
 or a male boss, women chose a preference for a male boss 39% of the 
time, compared to 26% of men displaying preference for a male boss.  
Only 27% of females would prefer a boss of the same gender.
  This preference, among both sexes, for male leadership in the 
workplace has continued unabated for sixty years, according to the 
survey results.
Religion
Sex differences in religion can be classified as either "internal" or
 "external." Internal religious issues are studied from the perspective 
of a given religion, and might include religious beliefs and practices 
about the roles and rights of men and women in government, education and
 worship; beliefs about the sex or gender of deities and religious 
figures; and beliefs about the origin and meaning of human gender. 
External religious issues can be broadly defined as an examination of a 
given religion from an outsider's perspective, including possible 
clashes between religious leaders and laity;
 and the influence of, and differences between, religious perspectives 
on social issues. For example, various religious perspectives have 
either endorsed or condemned alternative family structures, homosexual 
relationships, and abortion. External religious issues can also be examined from the "lens of gender" perspective embraced by some in feminism or critical theory and its offshoots.
Social capital
Sex differences in social capital are differences between men and 
women in their ability to coordinate actions and achieve their aims 
through trust, norms and networks. Social capital
 is often seen as the missing link in development; as social networks 
facilitate access to resources and protect the commons, while 
cooperation makes markets work more efficiently.
 Social capital has been thought of as women's capital as whereas there 
are gendered barriers to accessing economic capital, women's role in 
family, and community ensures that they have strong networks. There is 
potential that the concept can help to bring women's unpaid 'community 
and household labor',
 vital to survival and development, to the attention of economists. 
However, research analyzing social capital from a gendered perspective 
is rare, and the notable exceptions are very critical.
Suicide
Sex differences in suicide have been shown to be significant; there 
are highly asymmetric rates of attempted and completed suicide between 
males and females. The gap, also called the gender paradox of suicidal behavior, can vary significantly between different countries. Statistics indicate that males die much more often by means of suicide than do females, however reported suicide attempts are 3 times more common among females than males.
 This paradox is partially explained by the methodology, with females 
more often choosing medication-induced overdosage, and males more often 
turning to weapons such as firearms or knives.
Financial risk-taking
Sex
 differences in financial decision making are relevant and significant. 
Numerous studies have found that women tend to be financially more 
risk-averse than men and hold safer portfolios.
 A May 3, 2015 article in the Wall Street Journal by Georgette Jasen 
reported that "when it comes to investing, men sometimes have their way 
of doing things, and women have different ways."
 Scholarly research has documented systematic differences in financial 
decisions such as buying investments versus insurance, donating to 
ingroups versus outgroups (such as terrorism victims in Iraq versus 
USA), spending in stores, and the endowment effect-or asking price for goods people have. The majority of these studies are based on the theory of agency-communion developed by David Bakan in 1966;
 according to this theory, due to factors such as socialization, males 
are typically more agentic (focus on self, upside potential, 
aggressiveness) and females typically more communal (focus on others, 
downside potential, and nurturing). This framework robustly explains 
many financial decision making outcomes.