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Friday, August 29, 2025

Conspiracy theory

From Wikipedia, the free encyclopedia
The Eye of Providence, as seen on the US$1 bill, has been perceived by some to be evidence of a conspiracy linking the Founding Fathers of the United States to the New World Order conspiracy theory.

A conspiracy theory is an explanation for an event or situation that asserts the existence of a conspiracy (generally by powerful sinister groups, often political in motivation), when other explanations are more probable. The term generally has a negative connotation, implying that the appeal of a conspiracy theory is based in prejudice, emotional conviction, insufficient evidence, and/or paranoia. A conspiracy theory is distinct from a conspiracy; it refers to a hypothesized conspiracy with specific characteristics, including but not limited to opposition to the mainstream consensus among those who are qualified to evaluate its accuracy, such as scientists or historians. As such conspiracy theories are identified as lay theories.

Conspiracy theories tend to be internally consistent and correlate with each other; they are generally designed to resist falsification either by evidence against them or a lack of evidence for them. They are reinforced by circular reasoning: both evidence against the conspiracy and absence of evidence for it are misinterpreted as evidence of its truth. Psychologist Stephan Lewandowsky observes "the stronger the evidence against a conspiracy, the more the conspirators must want people to believe their version of events." As a consequence, the conspiracy becomes a matter of faith rather than something that can be proven or disproven. Studies have linked belief in conspiracy theories to distrust of authority and political cynicism. Some researchers suggest that conspiracist ideation—belief in conspiracy theories—may be psychologically harmful or pathological. Such belief is correlated with psychological projection, paranoia, and Machiavellianism.

Psychologists usually attribute belief in conspiracy theories to a number of psychopathological conditions such as paranoia, schizotypy, narcissism, and insecure attachment, or to a form of cognitive bias called "illusory pattern perception". It has also been linked with the so-called Dark triad personality types, whose common feature is lack of empathy. However, a 2020 review article found that most cognitive scientists view conspiracy theorizing as typically nonpathological, given that unfounded belief in conspiracy is common across both historical and contemporary cultures, and may arise from innate human tendencies towards gossip, group cohesion, and religion. One historical review of conspiracy theories concluded that "Evidence suggests that the aversive feelings that people experience when in crisis—fear, uncertainty, and the feeling of being out of control—stimulate a motivation to make sense of the situation, increasing the likelihood of perceiving conspiracies in social situations."

Historically, conspiracy theories have been closely linked to prejudice, propaganda, witch hunts, wars, and genocides. They are often strongly believed by the perpetrators of terrorist attacks, and were used as justification by Timothy McVeigh and Anders Breivik, as well as by governments such as Nazi Germany, the Soviet Union, and TurkeyAIDS denialism by the government of South Africa, motivated by conspiracy theories, caused an estimated 330,000 deaths from AIDS. QAnon and denialism about the 2020 United States presidential election results led to the January 6 United States Capitol attack, and belief in conspiracy theories about genetically modified foods led the government of Zambia to reject food aid during a famine, at a time when three million people in the country were suffering from hunger. Conspiracy theories are a significant obstacle to improvements in public health, encouraging opposition to such public health measures as vaccination and water fluoridation. They have been linked to outbreaks of vaccine-preventable diseases. Other effects of conspiracy theories include reduced trust in scientific evidence, radicalization and ideological reinforcement of extremist groups, and negative consequences for the economy.

Conspiracy theories once limited to fringe audiences have become commonplace in mass media, the Internet, and social media, emerging as a cultural phenomenon of the late 20th and early 21st centuries. They are widespread around the world and are often commonly believed, some even held by the majority of the population. Interventions to reduce the occurrence of conspiracy beliefs include maintaining an open society, encouraging people to use analytical thinking, and reducing feelings of uncertainty, anxiety, or powerlessness.

Origin and usage

The Oxford English Dictionary defines conspiracy theory as "the theory that an event or phenomenon occurs as a result of a conspiracy between interested parties; spec. a belief that some covert but influential agency (typically political in motivation and oppressive in intent) is responsible for an unexplained event". It cites a 1909 article in The American Historical Review as the earliest usage example, although it also appeared in print for several decades before.

The earliest known usage was by the American author Charles Astor Bristed, in a letter to the editor published in The New York Times on 11 January 1863. He used it to refer to claims that British aristocrats were intentionally weakening the United States during the American Civil War in order to advance their financial interests.

England has had quite enough to do in Europe and Asia, without going out of her way to meddle with America. It was a physical and moral impossibility that she could be carrying on a gigantic conspiracy against us. But our masses, having only a rough general knowledge of foreign affairs, and not unnaturally somewhat exaggerating the space which we occupy in the world's eye, do not appreciate the complications which rendered such a conspiracy impossible. They only look at the sudden right-about-face movement of the English Press and public, which is most readily accounted for on the conspiracy theory.

The term is also used as a way to discredit dissenting analyses. Robert Blaskiewicz comments that examples of the term were used as early as the nineteenth century and states that its usage has always been derogatory. According to a study by Andrew McKenzie-McHarg, in contrast, in the nineteenth century the term conspiracy theory simply "suggests a plausible postulate of a conspiracy" and "did not, at this stage, carry any connotations, either negative or positive", though sometimes a postulate so-labeled was criticized. The author and activist George Monbiot argued that the terms "conspiracy theory" and "conspiracy theorist" are misleading, as conspiracies truly exist and theories are "rational explanations subject to disproof". Instead, he proposed the terms "conspiracy fiction" and "conspiracy fantasist".

Alleged CIA origins

The Warren Report

The term "conspiracy theory" is itself the subject of a conspiracy theory, which posits that the term was popularized by the CIA in order to discredit conspiratorial believers, particularly critics of the Warren Commission, by making them a target of ridicule. In his 2013 book Conspiracy Theory in America, the political scientist Lance deHaven-Smith wrote that the term entered everyday language in the United States after 1964, the year in which the Warren Commission published its findings on the assassination of John F. Kennedy, with The New York Times running five stories that year using the term.

Whether the CIA was responsible for popularising the term "conspiracy theory" was analyzed by Michael Butter, a Professor of American Literary and Cultural History at the University of Tübingen. Butter wrote in 2020 that the CIA document Concerning Criticism of the Warren Report, which proponents of the theory use as evidence of CIA motive and intention, does not contain the phrase "conspiracy theory" in the singular, and only uses the term "conspiracy theories" once, in the sentence: "Conspiracy theories have frequently thrown suspicion on our organisation [sic], for example, by falsely alleging that Lee Harvey Oswald worked for us."

Difference from conspiracy

A conspiracy theory is not simply a conspiracy, which refers to any covert plan involving two or more people. In contrast, the term "conspiracy theory" refers to hypothesized conspiracies that have specific characteristics. For example, conspiracist beliefs invariably oppose the mainstream consensus among those people who are qualified to evaluate their accuracy, such as scientists or historians. Conspiracy theorists see themselves as having privileged access to socially persecuted knowledge or a stigmatized mode of thought that separates them from the masses who believe the official account. Michael Barkun describes a conspiracy theory as a "template imposed upon the world to give the appearance of order to events".

Real conspiracies, even very simple ones, are difficult to conceal and routinely experience unexpected problems. In contrast, conspiracy theories suggest that conspiracies are unrealistically successful and that groups of conspirators, such as bureaucracies, can act with near-perfect competence and secrecy. The causes of events or situations are simplified to exclude complex or interacting factors, as well as the role of chance and unintended consequences. Nearly all observations are explained as having been deliberately planned by the alleged conspirators.

In conspiracy theories, the conspirators are usually claimed to be acting with extreme malice. As described by Robert Brotherton:

The malevolent intent assumed by most conspiracy theories goes far beyond everyday plots borne out of self-interest, corruption, cruelty, and criminality. The postulated conspirators are not merely people with selfish agendas or differing values. Rather, conspiracy theories postulate a black-and-white world in which good is struggling against evil. The general public is cast as the victim of organised persecution, and the motives of the alleged conspirators often verge on pure maniacal evil. At the very least, the conspirators are said to have an almost inhuman disregard for the basic liberty and well-being of the general population. More grandiose conspiracy theories portray the conspirators as being Evil Incarnate: of having caused all the ills from which we suffer, committing abominable acts of unthinkable cruelty on a routine basis, and striving ultimately to subvert or destroy everything we hold dear.

Examples

A conspiracy theory may take any matter as its subject, but certain subjects attract greater interest than others. Favored subjects include famous deaths and assassinations, morally dubious government activities, suppressed technologies, and "false flag" terrorism. Among the best-known conspiracy theories relate to the assassination of John F. Kennedy, the 1969 Apollo Moon landings, and the 9/11 terrorist attacks, as well as numerous theories pertaining to alleged plots for world domination by various groups, both real and imaginary.

Popularity

Conspiracy beliefs are widespread around the world. In rural Africa, common targets of conspiracy theorizing include societal elites, enemy tribes, and the Western world, with conspirators often alleged to enact their plans via sorcery or witchcraft; one common belief identifies modern technology as itself being a form of sorcery, created with the goal of harming or controlling the people. In China, one widely published conspiracy theory claims that a number of events including the rise of Hitler, the 1997 Asian financial crisis, and climate change were planned by the Rothschild family, which may have led to effects on discussions about China's currency policy.

Conspiracy theories once limited to fringe audiences have become commonplace in mass media, contributing to conspiracism emerging as a cultural phenomenon in the United States of the late 20th and early 21st centuries. The general predisposition to believe conspiracy theories cuts across partisan and ideological lines. Conspiratorial thinking is correlated with antigovernmental orientations and a low sense of political efficacy, with conspiracy believers perceiving a governmental threat to individual rights and displaying a deep skepticism that who one votes for really matters.

Conspiracy theories are often commonly believed, some even being held by the majority of the population. A broad cross-section of Americans today gives credence to at least some conspiracy theories. For instance, a study conducted in 2016 found that 10% of Americans think the chemtrail conspiracy theory is "completely true" and 20–30% think it is "somewhat true". This puts "the equivalent of 120 million Americans in the 'chemtrails are real' camp". Belief in conspiracy theories has therefore become a topic of interest for sociologists, psychologists and experts in folklore.

Conspiracy theories are widely present on the Web in the form of blogs and YouTube videos, as well as on social media. Whether the Web has increased the prevalence of conspiracy theories or not is an open research question. The presence and representation of conspiracy theories in search engine results has been monitored and studied, showing significant variation across different topics, and a general absence of reputable, high-quality links in the results.

One conspiracy theory that propagated through former US President Barack Obama's time in office claimed that he was born in Kenya, instead of Hawaii where he was actually born. Former governor of Arkansas and political opponent of Obama Mike Huckabee made headlines in 2011 when he, among other members of Republican leadership, continued to question Obama's citizenship status.

Belief in conspiracy theories in the United States, December 2020 – NPR/Ipsos poll, ±3.3%
Conspiracy theory Believe Not sure
"A group of Satan-worshipping elites who run a child sex ring are trying to control our politics and media" (QAnon)
17%
37%
"Several mass shootings in recent years were staged hoaxes" (crisis actor theory)
12%
27%
Barack Obama was not born in the United States (birtherism)
19%
22%
Moon landing conspiracy theories
8%
20%
9/11 conspiracy theories
7%
20%

Types

A conspiracy theory can be local or international, focused on single events or covering multiple incidents and entire countries, regions and periods of history. According to Russell Muirhead and Nancy Rosenblum, historically, traditional conspiracism has entailed a "theory", but over time, "conspiracy" and "theory" have become decoupled, as modern conspiracism is often without any kind of theory behind it.

Walker's five kinds

Jesse Walker (2013) has identified five kinds of conspiracy theories:

  • The "Enemy Outside" refers to theories based on figures alleged to be scheming against a community from without.
  • The "Enemy Within" finds the conspirators lurking inside the nation, indistinguishable from ordinary citizens.
  • The "Enemy Above" involves powerful people manipulating events for their own gain.
  • The "Enemy Below" features the lower classes working to overturn the social order.
  • The "Benevolent Conspiracies" are angelic forces that work behind the scenes to improve the world and help people.

Barkun's three types

Michael Barkun has identified three classifications of conspiracy theory:

  • Event conspiracy theories. This refers to limited and well-defined events. Examples may include such conspiracies theories as those concerning the Kennedy assassination, 9/11, and the spread of AIDS.
  • Systemic conspiracy theories. The conspiracy is believed to have broad goals, usually conceived as securing control of a country, a region, or even the entire world. The goals are sweeping, whilst the conspiratorial machinery is generally simple: a single, evil organization implements a plan to infiltrate and subvert existing institutions. This is a common scenario in conspiracy theories that focus on the alleged machinations of Jews, Freemasons, Communism, or the Catholic Church.
  • Superconspiracy theories. For Barkun, such theories link multiple alleged conspiracies together hierarchically. At the summit is a distant but all-powerful evil force. His cited examples are the ideas of David Icke and Milton William Cooper.

Rothbard: shallow vs. deep

Murray Rothbard argues in favor of a model that contrasts "deep" conspiracy theories to "shallow" ones. According to Rothbard, a "shallow" theorist observes an event and asks Cui bono? ("Who benefits?"), jumping to the conclusion that a posited beneficiary is responsible for covertly influencing events. On the other hand, the "deep" conspiracy theorist begins with a hunch and then seeks out evidence. Rothbard describes this latter activity as a matter of confirming with certain facts one's initial paranoia.

Lack of evidence

Belief in conspiracy theories is generally based not on evidence but on the faith of the believer. As such conspiracy theories are identified as lay theories Noam Chomsky contrasts conspiracy theory to institutional analysis, which focuses mainly on the public, long-term behavior of publicly known institutions, as recorded in, for example, scholarly documents or mainstream media reports. Conspiracy theory conversely posits the existence of secretive coalitions of individuals and speculates on their alleged activities. Belief in conspiracy theories is associated with biases in reasoning, such as the conjunction fallacy.

Clare Birchall at King's College London describes conspiracy theory as a "form of popular knowledge or interpretation". The use of the word 'knowledge' here suggests ways in which conspiracy theory may be considered in relation to legitimate modes of knowing. The relationship between legitimate and illegitimate knowledge, Birchall claims, is closer than common dismissals of conspiracy theory contend.

Theories involving multiple conspirators that are proven to be correct, such as the Watergate scandal, are usually referred to as investigative journalism or historical analysis rather than conspiracy theory. Bjerg (2016) writes: "the way we normally use the term conspiracy theory excludes instances where the theory has been generally accepted as true. The Watergate scandal serves as the standard reference." By contrast, the term "Watergate conspiracy theory" is used to refer to a variety of hypotheses in which those convicted in the conspiracy were in fact the victims of a deeper conspiracy. There are also attempts to analyze the theory of conspiracy theories (conspiracy theory theory) to ensure that the term "conspiracy theory" is used to refer to narratives that have been debunked by experts, rather than as a generalized dismissal.

Rhetoric

Conspiracy theory rhetoric exploits several important cognitive biases, including proportionality bias, attribution bias, and confirmation bias. Their arguments often take the form of asking reasonable questions, but without providing an answer based on strong evidence. Conspiracy theories are most successful when proponents can gather followers from the general public, such as in politics, religion and journalism. These proponents may not necessarily believe the conspiracy theory; instead, they may just use it in an attempt to gain public approval. Conspiratorial claims can act as a successful rhetorical strategy to convince a portion of the public via appeal to emotion.

Conspiracy theories typically justify themselves by focusing on gaps or ambiguities in knowledge, and then arguing that the true explanation for this must be a conspiracy.[64] In contrast, any evidence that directly supports their claims is generally of low quality. For example, conspiracy theories are often dependent on eyewitness testimony, despite its unreliability, while disregarding objective analyses of the evidence.

Conspiracy theories are not able to be falsified and are reinforced by fallacious arguments. In particular, the logical fallacy circular reasoning is used by conspiracy theorists: both evidence against the conspiracy and an absence of evidence for it are re-interpreted as evidence of its truth, whereby the conspiracy becomes a matter of faith rather than something that can be proved or disproved. The epistemic strategy of conspiracy theories has been called "cascade logic": each time new evidence becomes available, a conspiracy theory is able to dismiss it by claiming that even more people must be part of the cover-up. Any information that contradicts the conspiracy theory is suggested to be disinformation by the alleged conspiracy. Similarly, the continued lack of evidence directly supporting conspiracist claims is portrayed as confirming the existence of a conspiracy of silence; the fact that other people have not found or exposed any conspiracy is taken as evidence that those people are part of the plot, rather than considering that it may be because no conspiracy exists. This strategy lets conspiracy theories insulate themselves from neutral analyses of the evidence, and makes them resistant to questioning or correction, which is called "epistemic self-insulation".

In 2013, 97% of peer-reviewed climate science papers that took a position on the cause of global warming said that humans are responsible, 3% said they were not. Among Fox News guests the same year, this was presented as a false balance between the two viewpoints, with 31% of invited guests believing it was happening and 69% not.

Conspiracy theorists often take advantage of false balance in the media. They may claim to be presenting a legitimate alternative viewpoint that deserves equal time to argue its case; for example, this strategy has been used by the Teach the Controversy campaign to promote intelligent design, which often claims that there is a conspiracy of scientists suppressing their views. If they successfully find a platform to present their views in a debate format, they focus on using rhetorical ad hominems and attacking perceived flaws in the mainstream account, while avoiding any discussion of the shortcomings in their own position.

The typical approach of conspiracy theories is to challenge any action or statement from authorities, using even the most tenuous justifications. Responses are then assessed using a double standard, where failing to provide an immediate response to the satisfaction of the conspiracy theorist will be claimed to prove a conspiracy. Any minor errors in the response are heavily emphasized, while deficiencies in the arguments of other proponents are generally excused.

In science, conspiracists may suggest that a scientific theory can be disproven by a single perceived deficiency, even though such events are extremely rare. In addition, both disregarding the claims and attempting to address them will be interpreted as proof of a conspiracy. Other conspiracist arguments may not be scientific; for example, in response to the IPCC Second Assessment Report in 1996, much of the opposition centered on promoting a procedural objection to the report's creation. Specifically, it was claimed that part of the procedure reflected a conspiracy to silence dissenters, which served as motivation for opponents of the report and successfully redirected a significant amount of the public discussion away from the science.

Consequences

Third Reich Nazi antisemitic propaganda poster entitled Das jüdische Komplott ("The Jewish Conspiracy")

Historically, conspiracy theories have been closely linked to prejudice, witch hunts, wars, and genocides. They are often strongly believed by the perpetrators of terrorist attacks, and were used as justification by Timothy McVeigh, Anders Breivik and Brenton Tarrant, as well as by governments such as Nazi Germany and the Soviet UnionAIDS denialism by the government of South Africa, motivated by conspiracy theories, caused an estimated 330,000 deaths from AIDS, while belief in conspiracy theories about genetically modified foods led the government of Zambia to reject food aid during a famine, at a time when 3 million people in the country were suffering from hunger.

Conspiracy theories are a significant obstacle to improvements in public health. People who believe in health-related conspiracy theories are less likely to follow medical advice, and more likely to use alternative medicine instead. Conspiratorial anti-vaccination beliefs, such as conspiracy theories about pharmaceutical companies, can result in reduced vaccination rates and have been linked to outbreaks of vaccine-preventable diseases. Health-related conspiracy theories often inspire resistance to water fluoridation, and contributed to the impact of the Lancet MMR autism fraud.

Conspiracy theories are a fundamental component of a wide range of radicalized and extremist groups, where they may play an important role in reinforcing the ideology and psychology of their members as well as further radicalizing their beliefs. These conspiracy theories often share common themes, even among groups that would otherwise be fundamentally opposed, such as the antisemitic conspiracy theories found among political extremists on both the far right and far left. More generally, belief in conspiracy theories is associated with holding extreme and uncompromising viewpoints, and may help people in maintaining those viewpoints. While conspiracy theories are not always present in extremist groups, and do not always lead to violence when they are, they can make the group more extreme, provide an enemy to direct hatred towards, and isolate members from the rest of society. Conspiracy theories are most likely to inspire violence when they call for urgent action, appeal to prejudices, or demonize and scapegoat enemies.

Conspiracy theorizing in the workplace can also have economic consequences. For example, it leads to lower job satisfaction and lower commitment, resulting in workers being more likely to leave their jobs. Comparisons have also been made with the effects of workplace rumors, which share some characteristics with conspiracy theories and result in both decreased productivity and increased stress. Subsequent effects on managers include reduced profits, reduced trust from employees, and damage to the company's image.

Conspiracy theories can divert attention from important social, political, and scientific issues. In addition, they have been used to discredit scientific evidence to the general public or in a legal context. Conspiratorial strategies also share characteristics with those used by lawyers who are attempting to discredit expert testimony, such as claiming that the experts have ulterior motives in testifying, or attempting to find someone who will provide statements to imply that expert opinion is more divided than it actually is.

It is possible that conspiracy theories may also produce some compensatory benefits to society in certain situations. For example, they may help people identify governmental deceptions, particularly in repressive societies, and encourage government transparency. However, real conspiracies are normally revealed by people working within the system, such as whistleblowers and journalists, and most of the effort spent by conspiracy theorists is inherently misdirected. The most dangerous conspiracy theories are likely to be those that incite violence, scapegoat disadvantaged groups, or spread misinformation about important societal issues.

Interventions

Target audience

Strategies to address conspiracy theories have been divided into two categories based on whether the target audience is the conspiracy theorists or the general public. These strategies have been described as reducing either the supply or the demand for conspiracy theories. Both approaches can be used at the same time, although there may be issues of limited resources, or if arguments are used which may appeal to one audience at the expense of the other.

Brief scientific literacy interventions, particularly those focusing on critical thinking skills, can effectively undermine conspiracy beliefs and related behaviors. Research led by Penn State scholars, published in the Journal of Consumer Research, found that enhancing scientific knowledge and reasoning through short interventions, such as videos explaining concepts like correlation and causation, reduces the endorsement of conspiracy theories. These interventions were most effective against conspiracy theories based on faulty reasoning and were successful even among groups prone to conspiracy beliefs. The studies, involving over 2,700 participants, highlight the importance of educational interventions in mitigating conspiracy beliefs, especially when timed to influence critical decision-making.

General public

People who feel empowered are more resistant to conspiracy theories. Methods to promote empowerment include encouraging people to use analytical thinking, priming people to think of situations where they are in control, and ensuring that decisions by society and government are seen to follow procedural fairness (the use of fair decision-making procedures).

Methods of refutation which have shown effectiveness in various circumstances include: providing facts that demonstrate the conspiracy theory is false, attempting to discredit the source, explaining how the logic is invalid or misleading, and providing links to fact-checking websites. It can also be effective to use these strategies in advance, informing people that they could encounter misleading information in the future, and why the information should be rejected (also called inoculation or prebunking). While it has been suggested that discussing conspiracy theories can raise their profile and make them seem more legitimate to the public, the discussion can put people on guard instead as long as it is sufficiently persuasive.

Other approaches to reduce the appeal of conspiracy theories in general among the public may be based in the emotional and social nature of conspiratorial beliefs. For example, interventions that promote analytical thinking in the general public are likely to be effective. Another approach is to intervene in ways that decrease negative emotions, and specifically to improve feelings of personal hope and empowerment.

Conspiracy theorists

It is much more difficult to convince people who already believe in conspiracy theories. Conspiracist belief systems are not based on external evidence, but instead use circular logic where every belief is supported by other conspiracist beliefs. In addition, conspiracy theories have a "self-sealing" nature, in which the types of arguments used to support them make them resistant to questioning from others.

Characteristics of successful strategies for reaching conspiracy theorists have been divided into several broad categories: 1) Arguments can be presented by "trusted messengers", such as people who were formerly members of an extremist group. 2) Since conspiracy theorists think of themselves as people who value critical thinking, this can be affirmed and then redirected to encourage being more critical when analyzing the conspiracy theory. 3) Approaches demonstrate empathy, and are based on building understanding together, which is supported by modeling open-mindedness in order to encourage the conspiracy theorists to do likewise. 4) The conspiracy theories are not attacked with ridicule or aggressive deconstruction, and interactions are not treated like an argument to be won; this approach can work with the general public, but among conspiracy theorists it may simply be rejected.

Interventions that reduce feelings of uncertainty, anxiety, or powerlessness result in a reduction in conspiracy beliefs. Other possible strategies to mitigate the effect of conspiracy theories include education, media literacy, and increasing governmental openness and transparency. Due to the relationship between conspiracy theories and political extremism, the academic literature on deradicalization is also important.

One approach describes conspiracy theories as resulting from a "crippled epistemology", in which a person encounters or accepts very few relevant sources of information. A conspiracy theory is more likely to appear justified to people with a limited "informational environment" who only encounter misleading information. These people may be "epistemologically isolated" in self-enclosed networks. From the perspective of people within these networks, disconnected from the information available to the rest of society, believing in conspiracy theories may appear to be justified. In these cases, the solution would be to break the group's informational isolation.

Reducing transmission

Public exposure to conspiracy theories can be reduced by interventions that reduce their ability to spread, such as by encouraging people to reflect before sharing a news story. Researchers Carlos Diaz Ruiz and Tomas Nilsson have proposed technical and rhetorical interventions to counter the spread of conspiracy theories on social media.

Interventions to counter the spread of conspiracy theories on social media
Type of intervention Intervention
Technical Expose sources that insert and circulate conspiracy theories on social media (flagging).
Diminish the source's capacity to monetize conspiracies (demonetization).
Slow down the circulation of conspiracy theories (algorithm)
Rhetorical Issue authoritative corrections (fact-checking).
Authority-based corrections and fact-checking may backfire because personal worldviews cannot be proved wrong.
Enlist spokespeople that can be perceived as allies and insiders.
Rebuttals must spring from an epistemology that participants are already familiar with.
Give believers of conspiracies an "exit ramp" to dis-invest themselves without facing ridicule.

Government policies

The primary defense against conspiracy theories is to maintain an open society, in which many sources of reliable information are available, and government sources are known to be credible rather than propaganda. Additionally, independent nongovernmental organizations are able to correct misinformation without requiring people to trust the government. The absence of civil rights and civil liberties reduces the number of information sources available to the population, which may lead people to support conspiracy theories. Since the credibility of conspiracy theories can be increased if governments act dishonestly or otherwise engage in objectionable actions, avoiding such actions is also a relevant strategy.

Joseph Pierre has said that mistrust in authoritative institutions is the core component underlying many conspiracy theories and that this mistrust creates an epistemic vacuum and makes individuals searching for answers vulnerable to misinformation. Therefore, one possible solution is offering consumers a seat at the table to mend their mistrust in institutions. Regarding the challenges of this approach, Pierre has said, "The challenge with acknowledging areas of uncertainty within a public sphere is that doing so can be weaponized to reinforce a post-truth view of the world in which everything is debatable, and any counter-position is just as valid. Although I like to think of myself as a middle of the road kind of individual, it is important to keep in mind that the truth does not always lie in the middle of a debate, whether we are talking about climate change, vaccines, or antipsychotic medications."

Researchers have recommended that public policies should take into account the possibility of conspiracy theories relating to any policy or policy area, and prepare to combat them in advance. Conspiracy theories have suddenly arisen in the context of policy issues as disparate as land-use laws and bicycle-sharing programs. In the case of public communications by government officials, factors that improve the effectiveness of communication include using clear and simple messages, and using messengers which are trusted by the target population. Government information about conspiracy theories is more likely to be believed if the messenger is perceived as being part of someone's in-group. Official representatives may be more effective if they share characteristics with the target groups, such as ethnicity.

In addition, when the government communicates with citizens to combat conspiracy theories, online methods are more efficient compared to other methods such as print publications. This also promotes transparency, can improve a message's perceived trustworthiness, and is more effective at reaching underrepresented demographics. However, as of 2019, many governmental websites do not take full advantage of the available information-sharing opportunities. Similarly, social media accounts need to be used effectively in order to achieve meaningful communication with the public, such as by responding to requests that citizens send to those accounts. Other steps include adapting messages to the communication styles used on the social media platform in question, and promoting a culture of openness. Since mixed messaging can support conspiracy theories, it is also important to avoid conflicting accounts, such as by ensuring the accuracy of messages on the social media accounts of individual members of the organization.

Public health campaigns

Successful methods for dispelling conspiracy theories have been studied in the context of public health campaigns. A key characteristic of communication strategies to address medical conspiracy theories is the use of techniques that rely less on emotional appeals. It is more effective to use methods that encourage people to process information rationally. The use of visual aids is also an essential part of these strategies. Since conspiracy theories are based on intuitive thinking, and visual information processing relies on intuition, visual aids are able to compete directly for the public's attention.

In public health campaigns, information retention by the public is highest for loss-framed messages that include more extreme outcomes. However, excessively appealing to catastrophic scenarios (e.g. low vaccination rates causing an epidemic) may provoke anxiety, which is associated with conspiracism and could increase belief in conspiracy theories instead. Scare tactics have sometimes had mixed results, but are generally considered ineffective. An example of this is the use of images that showcase disturbing health outcomes, such as the impact of smoking on dental health. One possible explanation is that information processed via the fear response is typically not evaluated rationally, which may prevent the message from being linked to the desired behaviors.

A particularly important technique is the use of focus groups to understand exactly what people believe, and the reasons they give for those beliefs. This allows messaging to focus on the specific concerns that people identify, and on topics that are easily misinterpreted by the public, since these are factors which conspiracy theories can take advantage of. In addition, discussions with focus groups and observations of the group dynamics can indicate which anti-conspiracist ideas are most likely to spread.

Interventions that address medical conspiracy theories by reducing powerlessness include emphasizing the principle of informed consent, giving patients all the relevant information without imposing decisions on them, to ensure that they have a sense of control. Improving access to healthcare also reduces medical conspiracism. However, doing so by political efforts can also fuel additional conspiracy theories, which occurred with the Affordable Care Act (Obamacare) in the United States. Another successful strategy is to require people to watch a short video when they fulfil requirements such as registration for school or a drivers' license, which has been demonstrated to improve vaccination rates and signups for organ donation.

Another approach is based on viewing conspiracy theories as narratives which express personal and cultural values, making them less susceptible to straightforward factual corrections, and more effectively addressed by counter-narratives. Counter-narratives can be more engaging and memorable than simple corrections, and can be adapted to the specific values held by individuals and cultures. These narratives may depict personal experiences, or alternatively they can be cultural narratives. In the context of vaccination, examples of cultural narratives include stories about scientific breakthroughs, about the world before vaccinations, or about heroic and altruistic researchers. The themes to be addressed would be those that could be exploited by conspiracy theories to increase vaccine hesitancy, such as perceptions of vaccine risk, lack of patient empowerment, and lack of trust in medical authorities.

Backfire effects

It has been suggested that directly countering misinformation can be counterproductive. For example, since conspiracy theories can reinterpret disconfirming information as part of their narrative, refuting a claim can result in accidentally reinforcing it, which is referred to as a "backfire effect". In addition, publishing criticism of conspiracy theories can result in legitimizing them. In this context, possible interventions include carefully selecting which conspiracy theories to refute, requesting additional analyses from independent observers, and introducing cognitive diversity into conspiratorial communities by undermining their poor epistemology. Any legitimization effect might also be reduced by responding to more conspiracy theories rather than fewer.

There are psychological mechanisms by which backfire effects could potentially occur, but the evidence on this topic is mixed, and backfire effects are very rare in practice. A 2020 review of the scientific literature on backfire effects found that there have been widespread failures to replicate their existence, even under conditions that would be theoretically favorable to observing them. Due to the lack of reproducibility, as of 2020 most researchers believe that backfire effects are either unlikely to occur on the broader population level, or they only occur in very specific circumstances, or they do not exist. Brendan Nyhan, one of the researchers who initially proposed the occurrence of backfire effects, wrote in 2021 that the persistence of misinformation is most likely due to other factors.

In general, people do reject conspiracy theories when they learn about their contradictions and lack of evidence. For most people, corrections and fact-checking are very unlikely to have a negative impact, and there is no specific group of people in which backfire effects have been consistently observed. Presenting people with factual corrections, or highlighting the logical contradictions in conspiracy theories, has been demonstrated to have a positive effect in many circumstances. For example, this has been studied in the case of informing believers in 9/11 conspiracy theories about statements by actual experts and witnesses. One possibility is that criticism is most likely to backfire if it challenges someone's worldview or identity. This suggests that an effective approach may be to provide criticism while avoiding such challenges.

Psychology

The widespread belief in conspiracy theories has become a topic of interest for sociologists, psychologists, and experts in folklore since at least the 1960s, when a number of conspiracy theories arose regarding the assassination of U.S. President John F. Kennedy. Sociologist Türkay Salim Nefes underlines the political nature of conspiracy theories. He suggests that one of the most important characteristics of these accounts is their attempt to unveil the "real but hidden" power relations in social groups. The term "conspiracism" was popularized by academic Frank P. Mintz in the 1980s. According to Mintz, conspiracism denotes "belief in the primacy of conspiracies in the unfolding of history":

Conspiracism serves the needs of diverse political and social groups in America and elsewhere. It identifies elites, blames them for economic and social catastrophes, and assumes that things will be better once popular action can remove them from positions of power. As such, conspiracy theories do not typify a particular epoch or ideology.

Research suggests, on a psychological level, conspiracist ideation—belief in conspiracy theories—can be harmful or pathological, and is highly correlated with psychological projection, as well as with paranoia, which is predicted by the degree of a person's Machiavellianism. The propensity to believe in conspiracy theories is strongly associated with the mental health disorder of schizotypy. Conspiracy theories once limited to fringe audiences have become commonplace in mass media, emerging as a cultural phenomenon of the late 20th and early 21st centuries. Exposure to conspiracy theories in news media and popular entertainment increases receptiveness to conspiratorial ideas, and has also increased the social acceptability of fringe beliefs.

Conspiracy theories often use complicated and detailed arguments, including ones that appear analytical or scientific. However, belief in conspiracy theories is primarily driven by emotion. One of the most widely confirmed facts about conspiracy theories is that belief in a single conspiracy theory is often associated with belief in other conspiracy theories. This even applies when the conspiracy theories directly contradict each other—e.g., believing that Osama bin Laden was already dead before his compound in Pakistan was attacked makes the same person more likely to believe that he is still alive. One conclusion from this finding is that the content of a conspiracist belief is less important than the idea of a coverup by the authorities. Analytical thinking aids in reducing belief in conspiracy theories, in part because it emphasizes rational and critical cognition.

Some psychological scientists assert that explanations related to conspiracy theories can be, and often are, "internally consistent" with strong beliefs previously held prior to the event that sparked the belief in a conspiracy. People who believe in conspiracy theories tend to believe in other unsubstantiated claims, including pseudoscience and paranormal phenomena.

Attractions

Psychological motives for believing in conspiracy theories can be categorized as epistemic, existential, or social. These motives are particularly acute in vulnerable and disadvantaged populations. However, it does not appear that the beliefs help to address these motives; in fact, they may be self-defeating, acting to make the situation worse instead. For example, while conspiratorial beliefs can result from a perceived sense of powerlessness, exposure to conspiracy theories immediately suppresses personal feelings of autonomy and control. Furthermore, they also make people less likely to take actions that could improve their circumstances.

This is additionally supported by the fact that conspiracy theories have a number of disadvantageous attributes. For example, they promote a hostile and distrustful view of other people and groups allegedly acting based on antisocial and cynical motivations. This is expected to lead to increased social alienation and anomie and reduced social capital. Similarly, they depict the public as ignorant and powerless against the alleged conspirators, with important aspects of society determined by malevolent forces, a viewpoint that is likely to be disempowering.

Each person may endorse conspiracy theories for one of many different reasons. The most consistently demonstrated characteristics of people who find conspiracy theories appealing are a feeling of alienation, unhappiness or dissatisfaction with their situation, an unconventional worldview, and a sense of disempowerment. While various aspects of personality affect susceptibility to conspiracy theories, none of the Big Five personality traits are associated with conspiracy beliefs.

The political scientist Michael Barkun, discussing the usage of "conspiracy theory" in contemporary American culture, holds that this term is used for a belief that explains an event as the result of a secret plot by exceptionally powerful and cunning conspirators to achieve a malevolent end.According to Barkun, the appeal of conspiracism is threefold:

* First, conspiracy theories claim to explain what institutional analysis cannot. They appear to make sense out of a world that is otherwise confusing.

  • Second, they do so in an appealingly simple way, by dividing the world sharply between the forces of light, and the forces of darkness. They trace all evil back to a single source, the conspirators and their agents.
  • Third, conspiracy theories are often presented as special, secret knowledge unknown or unappreciated by others. For conspiracy theorists, the masses are a brainwashed herd, while the conspiracy theorists in the know can congratulate themselves on penetrating the plotters' deceptions.

This third point is supported by the research of Roland Imhoff, professor of social psychology at the Johannes Gutenberg University Mainz. His research suggests that the smaller the minority believing in a specific theory, the more attractive it is to conspiracy theorists. Humanistic psychologists argue that even if a posited cabal behind an alleged conspiracy is almost always perceived as hostile, there often remains an element of reassurance for theorists. This is because it is a consolation to imagine that humans create difficulties in human affairs and remain within human control. If a cabal can be implicated, there may be a hope of breaking its power or of joining it. Belief in the power of a cabal is an implicit assertion of human dignity—an unconscious affirmation that man is responsible for his own destiny.

People formulate conspiracy theories to explain, for example, power relations in social groups and the perceived existence of evil forces. Proposed psychological origins of conspiracy theorising include projection; the personal need to explain "a significant event [with] a significant cause;" and the product of various kinds and stages of thought disorder, such as paranoid disposition, ranging in severity to diagnosable mental illnesses. Some people prefer socio-political explanations over the insecurity of encountering random, unpredictable, or otherwise inexplicable events According to Berlet and Lyons, "Conspiracism is a particular narrative form of scapegoating that frames demonized enemies as part of a vast insidious plot against the common good, while it valorizes the scapegoater as a hero for sounding the alarm".

Causes

Some psychologists believe that a search for meaning is common in conspiracism. Once cognized, confirmation bias and avoidance of cognitive dissonance may reinforce the belief. When a conspiracy theory has become embedded within a social group, communal reinforcement may also play a part.

Inquiry into possible motives behind the accepting of irrational conspiracy theories has linked these beliefs to distress resulting from an event that occurred, such as the events of 9/11. Additional research suggests that "delusional ideation" is the trait most likely to indicate a stronger belief in conspiracy theories. Research also shows an increased attachment to these irrational beliefs leads to a decreased desire for civic engagement. Belief in conspiracy theories is correlated with low intelligence, lower analytical thinking, anxiety disorders, paranoia, and authoritarian beliefs.

Professor Quassim Cassam argues that conspiracy theorists hold their beliefs due to flaws in their thinking and, more precisely, their intellectual character. He cites philosopher Linda Trinkaus Zagzebski and her book Virtues of the Mind in outlining intellectual virtues (such as humility, caution, and carefulness) and intellectual vices (such as gullibility, carelessness, and closed-mindedness). Whereas intellectual virtues help reach sound examination, intellectual vices "impede effective and responsible inquiry", meaning that those prone to believing in conspiracy theories possess certain vices while lacking necessary virtues.

Some researchers have suggested that conspiracy theories could be partially caused by the human brain's mechanisms for detecting dangerous coalitions. Such a mechanism could have been helpful in the small-scale environment humanity evolved in but is mismatched in a modern, complex society and thus "misfire", perceiving conspiracies where none exist.

Projection

Some historians have argued that psychological projection is prevalent amongst conspiracy theorists. According to the argument, this projection is manifested in the form of attributing undesirable characteristics of the self to the conspirators. Historian Richard Hofstadter stated that:

This enemy seems on many counts a projection of the self; both the ideal and the unacceptable aspects of the self are attributed to him. A fundamental paradox of the paranoid style is the imitation of the enemy. The enemy, for example, may be the cosmopolitan intellectual, but the paranoid will outdo him in the apparatus of scholarship, even of pedantry. ... The Ku Klux Klan imitated Catholicism to the point of donning priestly vestments, developing an elaborate ritual and an equally elaborate hierarchy. The John Birch Society emulates Communist cells and quasi-secret operation through "front" groups, and preaches a ruthless prosecution of the ideological war along lines very similar to those it finds in the Communist enemy. Spokesmen of the various fundamentalist anti-Communist "crusades" openly express their admiration for the dedication, discipline, and strategic ingenuity the Communist cause calls forth.

Hofstadter also noted that "sexual freedom" is a vice frequently attributed to the conspiracist's target group, noting that "very often the fantasies of true believers reveal strong sadomasochistic outlets, vividly expressed, for example, in the delight of anti-Masons with the cruelty of Masonic punishments".

Physiology

Marcel Danesi suggests that people who believe conspiracy theories have difficulty rethinking situations. Exposure to those theories has caused neural pathways to be more rigid and less subject to change. Initial susceptibility to believing these theories' lies, dehumanizing language, and metaphors leads to the acceptance of larger and more extensive theories because the hardened neural pathways are already present. Repetition of the "facts" of conspiracy theories and their connected lies simply reinforces the rigidity of those pathways. Thus, conspiracy theories and dehumanizing lies are not mere hyperbole; they can actually change the way people think:

Unfortunately, research into this brain wiring also shows that once people begin to believe lies, they are unlikely to change their minds even when confronted with evidence that contradicts their beliefs. It is a form of brainwashing. Once the brain has carved out a well-worn path of believing deceit, it is even harder to step out of that path – which is how fanatics are born. Instead, these people will seek out information that confirms their beliefs, avoid anything that is in conflict with them, or even turn the contrasting information on its head, so as to make it fit their beliefs.

People with strong convictions will have a hard time changing their minds, given how embedded a lie becomes in the mind. In fact, there are scientists and scholars still studying the best tools and tricks to combat lies with some combination of brain training and linguistic awareness.

Sociology

In addition to psychological factors such as conspiracist ideation, sociological factors also help account for who believes in which conspiracy theories. Such theories tend to get more traction among election losers in society, for example, and the emphasis on conspiracy theories by elites and leaders tends to increase belief among followers with higher levels of conspiracy thinking. Christopher Hitchens described conspiracy theories as the "exhaust fumes of democracy": the unavoidable result of a large amount of information circulating among a large number of people.

Conspiracy theories may be emotionally satisfying, as they assign blame to a group to which the theorist does not belong and, thus, absolve the theorist of moral or political responsibility in society. Likewise, Roger Cohen writing for The New York Times has said that, "captive minds; ... resort to conspiracy theory because it is the ultimate refuge of the powerless. If you cannot change your own life, it must be that some greater force controls the world."

Sociological historian Holger Herwig found in studying German explanations for the origins of World War I, "Those events that are most important are hardest to understand because they attract the greatest attention from myth makers and charlatans." Justin Fox of Time magazine argues that Wall Street traders are among the most conspiracy-minded group of people, and ascribes this to the reality of some financial market conspiracies, and to the ability of conspiracy theories to provide necessary orientation in the market's day-to-day movements.

Influence of critical theory

Bruno Latour notes that the language and intellectual tactics of critical theory have been appropriated by those he describes as conspiracy theorists, including climate-change denialists and the 9/11 Truth movement: "Maybe I am taking conspiracy theories too seriously, but I am worried to detect, in those mad mixtures of knee-jerk disbelief, punctilious demands for proofs, and free use of powerful explanation from the social neverland, many of the weapons of social critique."

Fusion paranoia

Michael Kelly, a Washington Post journalist and critic of anti-war movements on both the left and right, coined the term "fusion paranoia" to refer to a political convergence of left-wing and right-wing activists around anti-war issues and civil liberties, which he said were motivated by a shared belief in conspiracism or shared anti-government views.

Barkun has adopted this term to refer to how the synthesis of paranoid conspiracy theories, which were once limited to American fringe audiences, has given them mass appeal and enabled them to become commonplace in mass media, thereby inaugurating an unrivaled period of people actively preparing for apocalyptic or millenarian scenarios in the United States of the late 20th and early 21st centuries. Barkun notes the occurrence of lone-wolf conflicts with law enforcement acting as a proxy for threatening the established political powers.

Viability

As evidence that undermines an alleged conspiracy grows, the number of alleged conspirators also grows in the minds of conspiracy theorists. This is because of an assumption that the alleged conspirators often have competing interests. For example, if Republican President George W. Bush is allegedly responsible for the 9/11 terrorist attacks, and the Democratic party did not pursue exposing this alleged plot, that must mean that both the Democratic and Republican parties are conspirators in the alleged plot. It also assumes that the alleged conspirators are so competent that they can fool the entire world, but so incompetent that even the unskilled conspiracy theorists can find mistakes they make that prove the fraud. At some point, the number of alleged conspirators, combined with the contradictions within the alleged conspirators' interests and competence, becomes so great that maintaining the theory becomes an obvious exercise in absurdity.

The physicist David Robert Grimes estimated the time it would take for a conspiracy to be exposed based on the number of people involved. His calculations used data from the PRISM surveillance program, the Tuskegee syphilis experiment, and the FBI forensic scandal. Grimes estimated that:

  • A Moon landing hoax would require the involvement of 411,000 people and would be exposed within 3.68 years;
  • Climate-change fraud would require a minimum of 29,083 people (published climate scientists only) and would be exposed within 26.77 years, or up to 405,000 people, in which case it would be exposed within 3.70 years;
  • A vaccination conspiracy would require a minimum of 22,000 people (without drug companies) and would be exposed within at least 3.15 years and at most 34.78 years depending on the number involved;
  • A conspiracy to suppress a cure for cancer would require 714,000 people and would be exposed within 3.17 years.

Grimes's study did not consider exposure by sources outside of the alleged conspiracy. It only considered exposure from within the alleged conspiracy through whistleblowers or through incompetence. Subsequent comments on the PubPeer website point out that these calculations must exclude successful conspiracies since, by definition, we don't know about them, and are wrong by an order of magnitude about Bletchley Park, which remained a secret far longer than Grimes' calculations predicted.

Terminology

The term "truth seeker" is adopted by some conspiracy theorists when describing themselves on social media. Conspiracy theorists are often referred to derogatorily as "cookers" in Australia. The term "cooker" is also loosely associated with the far right.

Politics

A 2008 poll found that majorities in only 9 of 17 countries believed that al-Qaeda carried out the 9/11 attacks.

The philosopher Karl Popper described the central problem of conspiracy theories as a form of fundamental attribution error, where every event is generally perceived as being intentional and planned, greatly underestimating the effects of randomness and unintended consequences. In his book The Open Society and Its Enemies, he used the term "the conspiracy theory of society" to denote the idea that social phenomena such as "war, unemployment, poverty, shortages ... [are] the result of direct design by some powerful individuals and groups". Popper argued that totalitarianism was founded on conspiracy theories which drew on imaginary plots which were driven by paranoid scenarios predicated on tribalism, chauvinism, or racism. He also noted that conspirators very rarely achieved their goal.

Historically, real conspiracies have usually had little effect on history and have had unforeseen consequences for the conspirators, in contrast to conspiracy theories, which often posit grand, sinister organizations or world-changing events, the evidence for which has been erased or obscured.As described by Bruce Cumings, history is instead "moved by the broad forces and large structures of human collectivities".

Arab world

Conspiracy theories are a prevalent feature of Arab culture and politics. Variants include conspiracies involving colonialism, Zionism, superpowers, oil, and the war on terrorism, which is often referred to in Arab media as a "war against Islam". For example, The Protocols of the Elders of Zion, an infamous hoax document purporting to be a Jewish plan for world domination, is commonly read and promoted in the Muslim world. Roger Cohen has suggested that the popularity of conspiracy theories in the Arab world is "the ultimate refuge of the powerless". Al-Mumin Said has noted the danger of such theories, for they "keep us not only from the truth but also from confronting our faults and problems". Osama bin Laden and Ayman al-Zawahiri used conspiracy theories about the United States to gain support for al-Qaeda in the Arab world, and as rhetoric to distinguish themselves from similar groups, although they may not have believed the conspiratorial claims themselves.

Turkey

Conspiracy theories are a prevalent feature of culture and politics in Turkey. Conspiracism is an important phenomenon in understanding Turkish politics. This is explained by a desire to "make up for our lost Ottoman grandeur", the humiliation of perceiving Turkey as part of "the malfunctioning half" of the world, and a "low level of media literacy among the Turkish population."

There are a wide variety of conspiracy theories including the Judeo-Masonic conspiracy theory, the international Jewish conspiracy theory, and the war against Islam conspiracy theory. For example, Islamists, dissatisfied with the modernist and secularist reforms that took place throughout the history of the Ottoman Empire and the Turkish Republic, have put forward many conspiracy theories to defame the Treaty of Lausanne, an important peace treaty for the country, and the republic's founder Kemal Atatürk. Another example is the Sèvres syndrome, a reference to the Treaty of Sèvres of 1920, a popular belief in Turkey that dangerous internal and external enemies, especially the West, are "conspiring to weaken and carve up the Turkish Republic".

United States

The historian Richard Hofstadter addressed the role of paranoia and conspiracism throughout U.S. history in his 1964 essay "The Paranoid Style in American Politics". Bernard Bailyn's classic The Ideological Origins of the American Revolution (1967) notes that a similar phenomenon could be found in North America during the time preceding the American Revolution. Conspiracism labels people's attitudes and the type of conspiracy theories that are more global and historical in proportion.

Harry G. West and others have noted that while conspiracy theorists may often be dismissed as a fringe minority, certain evidence suggests that a wide range of the U.S. believes in conspiracy theories. West also compares those theories to hypernationalism and religious fundamentalism.[183][184] Theologian Robert Jewett and philosopher John Shelton Lawrence attribute the enduring popularity of conspiracy theories in the U.S. to the Cold War, McCarthyism, and counterculture rejection of authority. They state that among both the left-wing and right-wing, there remains a willingness to use real events, such as Soviet plots, inconsistencies in the Warren Report, and the 9/11 attacks, to support the existence of unverified and ongoing large-scale conspiracies.[185]

In his studies of "American political demonology", historian Michael Paul Rogin too analyzed this paranoid style of politics that has occurred throughout American history. Conspiracy theories frequently identify an imaginary subversive group that is supposedly attacking the nation and requires the government and allied forces to engage in harsh extra-legal repression of those threatening subversives. Rogin cites examples from the Red Scares of 1919 to McCarthy's anti-communist campaign in the 1950s and, more recently, fears of immigrant hordes invading the US. Unlike Hofstadter, Rogin saw these "countersubversive" fears as frequently coming from those in power and dominant groups instead of from the dispossessed. Unlike Robert Jewett, Rogin blamed not the counterculture but America's dominant culture of liberal individualism and the fears it stimulated to explain the periodic eruption of irrational conspiracy theories.[186] The Watergate scandal has also been used to bestow legitimacy to other conspiracy theories, with Richard Nixon himself commenting that it served as a "Rorschach ink blot" which invited others to fill in the underlying pattern.[90]

Historian Kathryn S. Olmsted cites three reasons why Americans are prone to believing in government conspiracy theories:

  1. Genuine government overreach and secrecy during the Cold War, such as Watergate, the Tuskegee syphilis experiment, Project MKUltra, and the CIA's assassination attempts on Fidel Castro in collaboration with mobsters.
  2. Precedent set by official government-sanctioned conspiracy theories for propaganda, such as claims of German infiltration of the U.S. during World War II or the debunked claim that Saddam Hussein played a role in the 9/11 attacks.
  3. Distrust fostered by the government's spying on and harassment of dissenters, such as the Sedition Act of 1918, COINTELPRO, and as part of various Red Scares.[187]

Alex Jones referenced numerous conspiracy theories for convincing his supporters to endorse Ron Paul over Mitt Romney in the 2012 Republican Party presidential primaries and Donald Trump over Hillary Clinton in the 2016 United States presidential election.[188][189] Into the 2020s, the QAnon conspiracy theory alleges that Trump is fighting against a deep-state cabal of child sex-abusing and Satan-worshipping Democrats.

Assistive technology in sport

From Wikipedia, the free encyclopedia
A New York City Marathon competitor uses a racing wheelchair.

Assistive technology in sport is an area of technology design that is growing. Assistive technology is the array of new devices created to enable sports enthusiasts who have disabilities to play. Assistive technology may be used in disabled sports, where an existing sport is modified to enable players with a disability to participate; or, assistive technology may be used to invent completely new sports with athletes with disabilities exclusively in mind.

An increasing number of people with disabilities are participating in sports, leading to the development of new assistive technology. Assistive technology devices can be simple, "low-tech", or they may use highly advanced technology, with some even using computers. Assistive technology for sports may also be simple or advanced. Accordingly, assistive technology can be found in sports ranging from local community recreation to elite Paralympic games. More complex assistive technology devices have been developed over time, and as a result, sports for people with disabilities "have changed from being a clinical therapeutic tool to an increasingly competition-oriented activity".

Assistive devices

Assistive devices can enable exercise and training, on top of enabling participation in a sport. Below are some of the assistive devices currently available for different impairments:

  • Mobility impairments:
    • Light-weight wheelchairs for basketball, tennis, and racing
    • All-terrain wheelchairs with rugged frames and wheels for rolling over unpaved surfaces, like hiking trails, snow, or beach sand
    • High performance power wheelchairs for powerchair football (power soccer) and power hockey
    • Handcycles, or recumbent bicycles, which are like bicycles with pedals and steering using only the rider's arms
    • Cross-country sit skis that allow skiers to sit down and push along the trail with tips that dig into the snow
    • Weights that users strap onto their wrists rather than having to hold them with the hands
    • Gym equipment that lets users stay in a wheelchair while using arm exercise machines
    • Mitts with Velcro straps that help users to hold onto an exercise machine if their grip isn't strong enough
    • Elastic band or tubes that exercise muscles through resistance instead of weight
    • Paramobile devices such as specialized golf carts with support for standing assist players with mobility disabilities
    • Bowling balls with hand grips assist bowlers with limited use of their hands
    • One-handed fishing rods assist fishers who have limited mobility
  • Visual impairments:
    • Softballs that beep, so that people with visual problems can locate the ball to hit and catch it
    • Basketballs with jingle bells inside for people who have limited or no eyesight

Sports using assistive technology

Sports that use assistive technology may include the following:

  • Accessible Fishing & Hunting
  • Accessible Sailing / Boating / Kayaking
  • Adaptive Archery
  • Adaptive Bowling
  • Adaptive Flying
  • Adaptive Golf
  • Adaptive Horseback Riding/Equestrian
  • Adaptive Scuba Diving
  • Adaptive Shooting
  • Adaptive Skiing & Snowboarding
  • Adaptive Table Tennis
  • Adaptive Water Sports
  • Extreme Wheelchair Sports
  • Handcycling
  • Power Soccer
  • Quad Rugby
  • Sled, Floor & Power Hockey
  • Wheelchair Basketball
  • Wheelchair Curling
  • Wheelchair Fencing
  • Wheelchair Lacrosse
  • Wheelchair Pool and Billiards
  • Wheelchair Racing and Field Sports
  • Wheelchair Baseball
  • Wheelchair Softball
  • Wheelchair Table Tennis
  • Wheelchair Tennis
  • Wheelchair Volleyball
  • Wheelchair Weightlifting

Many of the sports listed above have attained international elite sport status, being included in the Paralympic Games.

Sports requiring assistive technology

Some sports have developed with the goal of creating a challenge that players with a disability could enjoy. These sports require assistive technology for all players as part of the game. Some examples are: Sledge (sled) hockey; wheelchair basketball; adaptive sailing, with boats designed especially for sailors with disabilities; Nordic (cross-country) skiing with "sit-ski" buckets; and handcycling races.

Sport wheelchair design

Sport wheelchairs are designed for the requirements of specific sports. Power chairs can also be fitted with assistive devices that are temporary adaptations to the demands of a sport, such as a kick plate attached to a power chair for powerchair football (power soccer).

Light-weight frames are a necessity for wheelchairs used in sports requiring sharp, fast turns and overall agility, such as tennis, basketball, and racing.

Chairs with reinforced frames and impact protection are required for contact sports, such as wheelchair rugby or basketball.

Racing chairs are designed with bucket seats, angled wheels for improved stability, and a t-frame with a third wheel in front, allowing precision steering and improved balance. The athlete and wheelchair are viewed together by some sport researchers as a unified performance system. Improvements can be made to chairs by evaluating the chair and athlete separately or in performance conditions together.

Prosthetics

Prosthetic devices come in a variety of designs suited to different athletic purposes. Prosthetic legs may be designed for rock climbing, running, or jumping. The technology is designed to attain goals, such as greater gait efficiency when running. The technology is constantly improving to meet the demands of athletes who set ever-higher sports challenges for themselves.

In 2008, the International Association of Athletics Federations (IAAF) began a worldwide debate when they established Rule 144.2(e), prohibiting the use of technical devices that offer a competitive advantage. South African athlete Oscar Pistorius, using energy-storing prosthetic legs, fought for the right to run against able-bodied athletes in the 2008 Olympic and Paralympic Games, and won the right to compete, although he did not meet the qualifying time required for the traditional able-bodied competitions.

Functional classification

Functional classification systems are used to evaluate and categorize athletes in elite sports. The classification determines the type and extent of assistive technology use by the athlete.

Organizations

Organizations and associations at the national and international level support the development of adaptive sport and recreation, often through the use of assistive technology for players. These organizations are "growing in number and scope".

Obstacles

Assistive technology has made sports accessible to many athletes who would have otherwise not been able to play. However, it has its downfalls. This technology is expensive, so many people will never have access to it. It can be subject to abuse, as some people use the technology when they don't actually need it. There have been rulings that athletes who use assistive technology have an advantage over "able-bodied" athletes.

Quantum triviality

From Wikipedia, the free encyclopedia
 

This Higgs triviality is similar to the Landau pole problem in quantum electrodynamics, where this quantum theory may be inconsistent at very high momentum scales unless the renormalized charge is set to zero, i.e., unless the field theory has no interactions. The Landau pole question is generally considered to be of minor academic interest for quantum electrodynamics because of the inaccessibly large momentum scale at which the inconsistency appears. This is not however the case in theories that involve the elementary scalar Higgs boson, as the momentum scale at which a "trivial" theory exhibits inconsistencies may be accessible to present experimental efforts such as at the Large Hadron Collider (LHC) at CERN. In these Higgs theories, the interactions of the Higgs particle with itself are posited to generate the masses of the W and Z bosons, as well as lepton masses like those of the electron and muon. If realistic models of particle physics such as the Standard Model suffer from triviality issues, the idea of an elementary scalar Higgs particle may have to be modified or abandoned.

The situation becomes more complex in theories that involve other particles however. In fact, the addition of other particles can turn a trivial theory into a nontrivial one, at the cost of introducing constraints. Depending on the details of the theory, the Higgs mass can be bounded or even calculable. These quantum triviality constraints are in sharp contrast to the picture one derives at the classical level, where the Higgs mass is a free parameter. Quantum triviality can also lead to a calculable Higgs mass in asymptotic safety scenarios.

Triviality and the renormalization group

Modern considerations of triviality are usually formulated in terms of the real-space renormalization group, largely developed by Kenneth Wilson and others. Investigations of triviality are usually performed in the context of lattice gauge theory. A deeper understanding of the physical meaning and generalization of the renormalization process, which goes beyond the dilatation group of conventional renormalizable theories, came from condensed matter physics. Leo P. Kadanoff's paper in 1966 proposed the "block-spin" renormalization group. The blocking idea is a way to define the components of the theory at large distances as aggregates of components at shorter distances.

This approach covered the conceptual point and was given full computational substance in Wilson's extensive important contributions. The power of Wilson's ideas was demonstrated by a constructive iterative renormalization solution of a long-standing problem, the Kondo problem, in 1974, as well as the preceding seminal developments of his new method in the theory of second-order phase transitions and critical phenomena in 1971. He was awarded the Nobel prize for these decisive contributions in 1982.

In more technical terms, let us assume that we have a theory described by a certain function of the state variables and a certain set of coupling constants . This function may be a partition function, an action, a Hamiltonian, etc. It must contain the whole description of the physics of the system.

Now we consider a certain blocking transformation of the state variables , the number of must be lower than the number of . Now let us try to rewrite the function only in terms of the . If this is achievable by a certain change in the parameters, , then the theory is said to be renormalizable. The most important information in the RG flow are its fixed points. The possible macroscopic states of the system, at a large scale, are given by this set of fixed points. If these fixed points correspond to a free field theory, the theory is said to be trivial. Numerous fixed points appear in the study of lattice Higgs theories, but the nature of the quantum field theories associated with these remains an open question.

Historical background

The first evidence of possible triviality of quantum field theories was obtained by Lev Landau, Alexei Abrikosov, and Isaak Khalatnikov by finding the following relation of the observable charge gobs with the "bare" charge g0,

where m is the mass of the particle, and Λ is the momentum cut-off. If g0 is finite, then gobs tends to zero in the limit of infinite cut-off Λ.

In fact, the proper interpretation of Eq.1 consists in its inversion, so that g0 (related to the length scale 1/Λ) is chosen to give a correct value of gobs,

The growth of g0 with Λ invalidates Eqs. (1) and (2) in the region g0 ≈ 1 (since they were obtained for g0 ≪ 1) and the existence of the "Landau pole" in Eq.2 has no physical meaning.

The actual behavior of the charge g(μ) as a function of the momentum scale μ is determined by the full Gell–Mann–Low equation (by Murray Gell-Mann and Francis E. Low)

which gives Eqs.(1),(2) if it is integrated under conditions g(μ) = gobs for μ = m and g(μ) = g0 for μ = Λ, when only the term with is retained in the right hand side.

The general behavior of relies on the appearance of the function β(g). According to the classification by Nikolay Bogolyubov and Dmitry Shirkov, there are three qualitatively different situations:

  1. if has a zero at the finite value g*, then growth of g is saturated, i.e. for ;
  2. if is non-alternating and behaves as with for large , then the growth of continues to infinity;
  3. if with for large , then is divergent at finite value and the real Landau pole arises: the theory is internally inconsistent due to indeterminacy of for .

The latter case corresponds to the quantum triviality in the full theory (beyond its perturbation context), as can be seen by reductio ad absurdum. Indeed, if gobs is finite, the theory is internally inconsistent. The only way to avoid it, is to tend to infinity, which is possible only for gobs → 0.

Conclusions

As a result, the question of whether the Standard Model of particle physics is nontrivial remains a serious unresolved question. Theoretical proofs of triviality of the pure scalar field theory exist, but the situation for the full standard model is unknown. The implied constraints on the standard model have been discussed.

Nerve injury

From Wikipedia, the free encyclopedia
Nerve injury
Micrograph of a nerve with a decrease in myelinated nerve fibres (pink) and an abnormal increase in fibrous tissue (yellow), as may be seen in nerve injuries. HPS stain.

Nerve injury is an injury to a nerve. There is no single classification system that can describe all the many variations of nerve injuries. In 1941, Herbert Seddon introduced a classification of nerve injuries based on three main types of nerve fiber injury and whether there is continuity of the nerve. Usually, however, nerve injuries are classified in five stages, based on the extent of damage to both the nerve and the surrounding connective tissue, since supporting glial cells may be involved.

Unlike in the central nervous system, neuroregeneration in the peripheral nervous system is possible. The processes that occur in peripheral regeneration can be divided into the following major events: Wallerian degeneration, axon regeneration/growth, and reinnervation of nervous tissue. The events that occur in peripheral regeneration occur with respect to the axis of the nerve injury. The proximal stump refers to the end of the injured neuron that is still attached to the neuron cell body; it is the part that regenerates. The distal stump refers to the end of the injured neuron that is still attached to the end of the axon; it is the part of the neuron that will degenerate, but the stump remains capable of regenerating its axons.

The study of nerve injury began during the American Civil War and greatly expanded during modern medicine with such advances as use of growth-promoting molecules.

Types

To assess the location and severity of a nerve injury, clinical assessment is commonly combined with electrodiagnostic tests. Injuries to the myelin are usually the least severe (neuropraxia), while injuries to the axons and supporting structures are more severe (axonotmesis is moderate injury, while neurotmesis is severe injury). It may be difficult to differentiate the severity by clinical findings due to common neurological impairments, including motor and sensory impairments distal to the lesion.

Neurapraxia

Nerve compression in neurapraxia

Neurapraxia is the least severe form of nerve injury, with complete recovery. In this case, the axon remains intact, but there is myelin damage causing an interruption in conduction of the impulse down the nerve fiber. Most commonly, this involves compression of the nerve or disruption to the blood supply (ischemia). There is a temporary loss of function which is reversible within hours to months of the injury (the average is 6–8 weeks). Wallerian degeneration does not occur, so recovery does not involve actual regeneration. There is frequently greater involvement of motor than sensory function with autonomic function being retained. In electrodiagnostic testing with nerve conduction studies, there is a normal compound motor action potential amplitude distal to the lesion at day 10, and this indicates a diagnosis of mild neurapraxia instead of axonotmesis or neurotmesis.

Axonotmesis

Axonotmesis is a more severe nerve injury with disruption of the neuronal axon, but with maintenance of the epineurium. This type of nerve damage may cause paralysis of the motor, sensory, and autonomic functions, and is mainly seen in crush injury.

If the force creating the nerve damage is removed in a timely fashion, the axon may regenerate, leading to recovery. Electrically, the nerve shows rapid and complete degeneration, with loss of voluntary motor units. Regeneration of the motor end plates will occur, as long as the endoneural tubules are intact.

Axonotmesis involves the interruption of the axon and its covering of myelin, but with preservation of the connective tissue framework of the nerve (the encapsulating tissue, the epineurium and perineurium, are preserved). Because axonal continuity is lost, Wallerian degeneration occurs. Electromyography (EMG) performed 2 to 4 weeks later shows fibrillations and denervation potentials in musculature distal to the injury site. Loss in both motor and sensory spines is more complete with axonotmesis than with neurapraxia, and recovery occurs only through regenerations of the axons, a process requiring time.

Axonotmesis is usually the result of a more severe crush or contusion than neurapraxia, but can also occur when the nerve is stretched (without damage to the epineurium). There is usually an element of retrograde proximal degeneration of the axon, and for regeneration to occur, this loss must first be overcome. The regeneration fibers must cross the injury site and regeneration through the proximal or retrograde area of degeneration may require several weeks. Then the neuritis tip progresses down the distal site, such as the wrist or hand. Proximal lesion may grow distally as fast as 2 to 3 mm per day and distal lesion as slowly as 1.5 mm per day. Regeneration occurs over weeks to years.

Neurotmesis

Neurotmesis is the most severe lesion with no potential of full recovery. It occurs on severe contusion, stretch, or laceration. The axon and encapsulating connective tissue lose their continuity. The last (extreme) degree of neurotmesis is transsection, but most neurotmetic injuries do not produce gross loss of continuity of the nerve but rather internal disruption of nerve structures sufficient to involve perineurium and endoneurium as well as axons and their covering. Denervation changes recorded by EMG are the same as those seen with axonotmetic injury. There is a complete loss of motor, sensory and autonomic function. If the nerve has been completely divided, axonal regeneration causes a neuroma to form in the proximal stump. For neurotmesis, it is better to use a new more complete classification called the Sunderland System.

Overview of peripheral regeneration

Wallerian degeneration is a process that occurs before nerve regeneration and can be described as a cleaning or clearing process that essentially prepares the distal stump for reinnervation. Schwann cells are glial cells in the peripheral nervous system that support neurons by forming myelin that encases nerves. During Wallerian degeneration Schwann cells and macrophages interact to remove debris, specifically myelin and the damaged axon, from the distal injury site. Calcium has a role in the degeneration of the damage axon. Bands of Büngner are formed when uninnervated Schwann cells proliferate and the remaining connective tissue basement membrane forms endoneurial tubes. Bands of Büngner are important for guiding the regrowing axon.

At the neuronal cell body, a process called chromatolysis occurs in which the nucleus migrates to the periphery of the cell body and the endoplasmic reticulum breaks up and disperses. Nerve damage causes the metabolic function of the cell to change from that of producing molecules for synaptic transmission to that of producing molecules for growth and repair. These factors include GAP-43, tubulin and actin. Chromatolysis is reversed when the cell is prepared for axon regeneration.

Axon regeneration is characterized by the formation of a growth cone, which has the ability to produce a protease that digests any material or debris that remains in its path of regeneration toward the distal site. The growth cone responds to molecules produced by Schwann cells such as laminin and fibronectin.

Neuron-intrinsic changes

Immediately following injury, neurons undergo a large number of transcriptional and proteomic changes which switch the cell from a mature, synaptically active neuron to a synaptically silent, growth state. This process is dependent on new transcription, as blocking the ability of cells to transcribe new mRNA severely impairs regeneration. A number of signaling pathways have been shown to be turned on by axon injury and help to enable long distance regeneration including BMP, TGFβ, and MAPKs. Similarly, a growing number of transcription factors also boost the regenerative capacity of peripheral neurons including ASCL1, ATF3, CREB1, HIF1α, JUN, KLF6, KLF7, MYC, SMAD1, SMAD2, SMAD3, SOX11, SRF, STAT3, TP53, and XBP1. Several of these can also boost the regenerative capacity of CNS neurons, making them potential therapeutic targets for treating spinal cord injury and stroke.

Role of Schwann cells

Guillain–Barré syndrome – nerve damage

Schwann cells are active in Wallerian degeneration. They not only have a role in phagocytosis of myelin, but they also have a role in recruitment of macrophages to continue the phagocytosis of myelin. The phagocytic role of Schwann cells has been investigated by studying the expression of molecules in Schwann cells that are typically specific to inflammatory macrophages. Expression of one such molecule MAC-2, a galactose-specific lectin, is observed in not only degenerating nerves that are macrophage-rich but also degenerating nerves that are macrophage-scarce and Schwann cell-rich. Furthermore, the effects of MAC-2 in degenerating nerves are associated with myelin phagocytosis. There was a positive correlation between the amount of MAC-2 expression and the extent of myelin phagocytosis. A deficiency in MAC-2 expression can even cause inhibition of myelin removal from injury sites.

Schwann cells are active in demyelination of injured nerves before macrophages are even present at the site of nerve injury. Electron microscopy and immunohistochemical staining analysis of teased nerve fibers shows that before macrophages arrive at the injury site, myelin is fragmented and myelin debris and lipid droplets are found in the cytoplasm of Schwann cells, indicating phagocytic activity before macrophages arrive.

Schwann cell activity includes recruitment of macrophages to the injury site. Monocyte chemoattractant protein (MCP-1) plays a role in recruiting monocytes/macrophages. In tellurium-induced demylenation with no axon degeneration, nerve crush with axon degeneration, and nerve transection with axon degeneration an increase in MCP-1 mRNA expression followed by an increase in macrophage recruitment occurred. In addition varying levels of MCP-1 mRNA expression also had an effect. Increased MCP-1 mRNA levels correlated positively with an increase in macrophage recruitment. Furthermore, in situ hybridation determined that the cellular source of MCP-1 was Schwann cells.

Schwann cells play an important role in not only producing neurotrophic factors such as nerve growth factor (NGF) and ciliary neurotrophic factor (CNTF), which promote growth, of both the damaged nerve and supporting Schwann cells, but also producing neurite promoting factors, which guide the growing axon, both of which are discussed below.

Role of macrophages

The primary role of macrophages in peripheral regeneration is demylenation during Wallerian degeneration. Immunohistochemical analysis showed that in tellurium demylenated, crushed, and cut nerves, expression of lysozyme, which is a marker for myelin phagocytosis, and of ED1, which is a marker for macrophages, occurred in the same region. Lysozyme was also investigated with respect to the temporal progression of myelin phagocytosis by macrophages in nerve injury. Northern blotting showed that peak lysozyme mRNA expression occurred at an appropriate time with respect to temporal models of myelin phagocytosis. Macrophages do not phagocytose all cellular debris at the nerve injury site; they are selective and will salvage certain factors. Macrophages produce apolipoprotein E which is involved in rescuing cholesterol in damaged nerves. In the same investigation, temporal levels of apolipoprotein E mRNA expression in the three models for demylenation and nerve damage were consistent with respect to models for cholesterol salvage in nerve injury. Macrophages play a role in salvaging cholesterol during nerve injury.

Macrophages also play a role in inducing the proliferation of Schwann cells that occurs during Wallerian degeneration. Supernatant has been collected from medium in which macrophages are active in myelin phagocytosis where lysosomal processing of the myelin occurs within the macrophage. The supernatant contains a mitogenic factor, a mitosis promoting factor, that is characterized heat and trypsin sensitivity, both of which characterize it as a peptide. Treatment of Schwann cells with the collected supernatant shows that it is a mitogenic factor and thus plays an important role in the proliferation of Schwann cells.

Macrophages are also involved in the secretion factors that promote nerve regeneration. Macrophages secrete not only interleukin-1, a cytokine that induces expression of nerve growth factor (NGF) in Schwann cells but also an interleukin-1 receptor antagonist (IL-1ra). Expression of IL-1ra in mice with transected sciatic nerves via implantation of a tube releasing IL-1ra showed the regrowth of fewer myelinated and unmyelinated axons. Macrophage secretion of interleukin-1 is involved in stimulation of nerve regeneration.

Role of neurotrophic factors

Several signaling pathways are upregulated following a nerve injury.

Neurotrophic factors are those that promote survival and growth of neurons. A trophic factor can be described as a factor that is associated with providing nourishment to allow for growth. In general they are protein ligands for tyrosine kinase receptors; binding to the specific receptor yields autophosphorylation and subsequent phosphorylation of tyrosine residues on proteins that participate in further downstream signaling to activate proteins and genes involved in growth and proliferation. Neurotrophic factors act through retrograde transport in neurons, in which they are taken up by the growth cone of the injured neuron and transported back to the cell body. These neurotrophic factors have both autocrine and paracrine effects, as they promote growth of the damaged neurons as well as the adjacent Schwann cells.

Nerve growth factor (NGF) typically has a low level of expression in nerves that are healthy and not growing or developing, but in response to nerve injury NGF expression increases in Schwann cells. This is a mechanism to increase growth and proliferation of Schwann cells at the distal stump in order to prepare for reception of the regenerating axon. NGF has not only a trophic role but also a tropic or guiding role. The Schwann cells that form the bands of Bungner at the distal injury site express NGF receptors as a guiding factor for the regenerating axon of the injured neuron. NGF bound to the receptors on Schwann cells provides the growing neurons that are contacted with a trophic factor to promote further growth and regeneration.

Ciliary neurotrophic factor (CNTF) typically has a high level of expression in Schwann cells associated with nerves that are healthy, but in response to nerve injury CNTF expression decreases in Schwann cells distal to the injury site and remains relatively low unless the injured axon begins to regrow. CNTF has numerous trophic roles in motor neurons in the peripheral nervous system including the prevention of atrophy of dennervated tissue and the prevention of degeneration and death of motor neurons after nerve injury. (frostick) In sciatic motor neurons both CNTF receptor mRNA expression and CNTF receptor is increased after injury for a prolonged time frame compared to the short time frame in the central nervous system suggesting a role for CNTF in nerve regeneration.

Insulin-like growth factors (IGFs) have been shown to increase the rate of peripheral nervous system axon regeneration. IGF-I and IGF-II mRNA levels are significantly increased distal to the site of crush injury in rat sciatic nerves. At the site of nerve repair, locally delivered IGF-I can significantly increase the rate of axon regeneration within a nerve graft and help expedite functional recovery of a paralyzed muscle.

Role of neurite-promoting factors

Neurite promoting factors include many extracellular matrix proteins produced by Schwann cells at the distal stump including fibronectin and laminin. Fibronectin are components of the basal lamina and promote neurite growth and adhesion of the growth cone to the basal lamina. In regenerating neural cells, neurite promoting factors play a role in adhesion of the axon and include neural cell adhesion molecule (N-CAM) and N-cadherin.

Treatment

Unless otherwise demonstrated, nerve injuries are commonly irreversible, and therefore complete treatment is rather difficult, though still possible and hence lifelong management of disabilities arising due to nerve injuries is necessary.

Nerve regeneration therapies

Electrical stimulation can promote nerve regeneration. The positive effect of electrical stimulation on nerve regeneration is due to its molecular influence on the damaged neuron and Schwann cells. Electrical stimulation can directly accelerate the expression of cyclic adenosine monophosphate (cAMP) both in neurons and Schwann cells. cAMP is a molecule that stimulates multiple signaling pathways that aid nerve regeneration by enhancing the expression of several neurotrophic factors. Electrical stimulation also results in the influx of calcium ions, which further triggers multiple regeneration pathways.

The frequency of stimulation is an important factor in the success of both quality and quantity of axon regeneration as well as growth of the surrounding myelin and blood vessels that support the axon. Histological analysis and measurement of regeneration showed that low frequency stimulation had a more successful outcome than high frequency stimulation on regeneration of damaged sciatic nerves.

Other studies have used both oscillating current (AC) and non-oscillating direct current (DC) stimulation to regenerate mammalian nerves. Mammalian neurons preferentially orient and grow towards the cathode in DC electric fields.

Surgery can be done in case a nerve has become cut or otherwise divided. Recovery of a nerve after surgical repair depends mainly on the age of patients. Younger the patients, better the prognosis, because of better healing capacity of young tissues. Young children can recover almost normal nerve function. In contrast, a patient over 60 years old with a cut nerve in the hand would expect to recover only protective sensory function, that is, the ability to distinguish hot/cold or sharp/dull; recovery of motor function would be likely incomplete. Many other factors also affect nerve recovery. The use of autologous nerve grafting procedures that involve redirection of regenerative donor nerve fibers into the graft conduit has been successful in restoring target muscle function. Localized delivery of soluble neurotrophic factors may help promote the rate of axon regeneration observed within these graft conduits.

An expanding area of nerve regeneration research deals with the development of scaffolding and bio-conduits. Scaffolding developed from bio-compatible material would be useful in nerve regeneration if they successfully exhibit essentially the same role as the endoneurial tubes and Schwann cells do in guiding regrowing axons.

Prevention of nerve injuries

Methods to help prevent nerve injuries include injection pressure monitoring.  The presence of a high opening injection pressure (> 20 PSI) is a sensitive sign of intrafascicular/intraneural needle tip placement.  Extrafascicular needle tip placement is associated with low pressures (< 20 PSI).  Also, high pressure injection was associated with neurologic deficits and severe axonal damage after the block.  Other methods of preventing nerve injury include electrical nerve stimulation and ultrasonography. Electrical stimulation with a motor response at < 0.2 mA only can occur with an intraneural/intrafasciular needle tip location.

Ability

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