Search This Blog

Saturday, December 27, 2025

Unintended consequences

From Wikipedia, the free encyclopedia
https://en.wikipedia.org/wiki/Unintended_consequences
A gully erosion in Australia caused by rabbits, an unintended consequence of their introduction as game animals

In the social sciences, unintended consequences (sometimes unanticipated consequences or unforeseen consequences, more colloquially called knock-on effects) are outcomes of a purposeful action that are not intended or foreseen. The term was popularized in the 20th century by American sociologist Robert K. Merton.

Unintended consequences can be grouped into three types:

  • Unexpected benefit: A positive unexpected benefit (also referred to as luck, serendipity, or a windfall).
  • Unexpected drawback: An unexpected detriment occurring in addition to the desired effect of the policy (e.g., while irrigation schemes provide people with water for agriculture, they can increase waterborne diseases that have devastating health effects, such as schistosomiasis).
  • Perverse result: A perverse effect contrary to what was originally intended (when an intended solution makes a problem worse).

History

John Locke

The idea of unintended consequences dates back at least to John Locke who discussed the unintended consequences of interest rate regulation in his letter to Sir John Somers, Member of Parliament.

Adam Smith

The idea was also discussed by Adam Smith, the Scottish Enlightenment, and consequentialism (judging by results).

The invisible hand theorem is an example of the unintended consequences of agents acting in their self-interest. As Andrew S. Skinner puts it:

"The individual undertaker (entrepreneur), seeking the most efficient allocation of resources, contributes to overall economic efficiency; the merchant's reaction to price signals helps to ensure that the allocation of resources accurately reflects the structure of consumer preferences; and the drive to better our condition contributes to economic growth."

Marx and Engels

Influenced by 19th century positivism and Charles Darwin's evolution, for both Friedrich Engels and Karl Marx, the idea of uncertainty and chance in social dynamics (and thus unintended consequences beyond results of perfectly defined laws) was only apparent, (if not rejected) since social actions were directed and produced by deliberate human intention.

While discerning between the forces that generate changes in nature and those that generate changes in history in his discussion of Ludwig Feuerbach, Friedrich Engels touched on the idea of (apparent) unintended consequences:

In nature [...] there are only blind, unconscious agencies acting upon one another, [...] In the history of society, on the contrary, the actors are all endowed with consciousness, are men acting with deliberation or passion, working towards definite goals; nothing happens without a conscious purpose, without an intended aim. [...] For here, also, on the whole, in spite of the consciously desired aims of all individuals, accident apparently reigns on the surface. That which is willed happens but rarely; in the majority of instances the numerous desired ends cross and conflict with one another, or these ends themselves are from the outset incapable of realization, or the means of attaining them are insufficient. Thus the conflicts of innumerable individual wills and individual actions in the domain of history produce a state of affairs entirely analogous to [...] the realm of unconscious nature. The ends of the actions are intended, but the results which actually follow from these actions are not intended; or when they do seem to correspond to the end intended, they ultimately have consequences quite other than those intended. Historical events thus appear on the whole to be likewise governed by chance. But where on the surface accident holds sway, there actually it is always governed by inner, hidden laws, and it is only a matter of discovering these laws.

— Ludwig Feuerbach and the End of Classical German Philosophy (Ludwig Feuerbach und der Ausgang der klassischen deutschen Philosophie), 1886.

For his part, for Karl Marx what can be understood as unintended consequences are actually consequences that should be expected but are obtained unconsciously. These consequences (that no one consciously sought) would be (in the same way as it is for Engels) product of conflicts that confront actions from countless individuals. The deviation between the original intended goal and the product derived from conflicts would be a marxist equivalent to «unintended consequences.

This social conflicts would happen as a result of a competitive society, and also lead society to sabotage itself and prevent historical progress. Thus, historical progress (in Marxist terms) should eliminate these conflicts and make unintended consequences predictable.

Austrian School

Unintended consequences are a common topic of study and commentary for the Austrian school of economics given its emphasis on methodological individualism. This is to such an extent that unexpected consequences can be considered as a distinctive part of Austrian tenets.

Carl Menger

In "Principles of Economics", Austrian school founder Carl Menger (1840 - 1921) noted that the relationships that occur in the economy are so intricate that a change in the condition of a single good can have ramifications beyond that good. Menger wrote:

If it is established that the existence of human needs capable of satisfaction is a prerequisite of goods-character [...] This principle is valid whether the goods can be placed in direct causal connection with the satisfaction of human needs, or derive their goods-character from a more or less indirect causal connection with the satisfaction of human needs. [...]
Thus quinine would cease to be a good if the diseases it serves to cure should disappear, since the only need with the satisfaction of which it is causally connected would no longer exist. But the disappearance of the usefulness of quinine would have the further consequence that a large part of the corresponding goods of higher order would also be deprived of their goods-character. The inhabitants of quinine-producing countries, who currently earn their livings by cutting and peeling cinchona trees, would suddenly find that not only their stocks of cinchona bark, but also, in consequence, their cinchona trees, the tools and appliances applicable only to the production of quinine, and above all the specialized labor services, by means of which they previously earned their livings, would at once lose their goods-character, since all these things would, under the changed circumstances, no longer have any causal relationship with the satisfaction of human needs.

— Principles of Economics (Grundsätze der Volkswirtschaftslehre), 1871.

Friedrich Hayek and Catallactics

Economist and philosopher Friedrich Hayek (1899 – 1992) is another key figure in the Austrian School of Economics who is notable for his comments on unintended consequences.

In "The Use of Knowledge in Society" (1945) Hayek argues that a centrally planned economy cannot reach the level of efficiency of the free market economy because the necessary (and pertinent) information for decision-making is not concentrated but dispersed among a vast number of agents. Then, for Hayek, the price system in the free market allows the members of a society to anonymously coordinate for the most efficient use of resources, for example, in a situation of scarcity of a raw material, the price increase would coordinate the actions of an uncountable amount of individuals "in the right direction".

The development of this system of interactions would allow the progress of society, and individuals would carry it out without knowing all its implications, given the dispersion (or lack of concentration) of information.

The implication of this is that the social order (which derives from social progress, which in turn derives from the economy), would be result of a spontaneous cooperation and also an unintended consequence, being born from a process of which no individual or group had all the information available or could know all possible outcomes.

In the Austrian school, this process of social adjustment that generates a social order in an unintendedly way is known as catallactics.

For Hayek and the Austrian School, the number of individuals involved in the process of creating a social order defines the type of unintended consequence:

  1. If the process involves interactions and decision making of as many individuals (members of a society) as possible (thus gathering the greatest amount of knowledge dispersed among them), this process of "catallaxy" will lead to unexpected benefits (a social order and progress)
  2. On the other hand, attempts by individuals or limited groups (who lack all the necessary information) to achieve a new or better order, will end in unexpected drawbacks.

Robert K. Merton

Sociologist Robert K. Merton popularised this concept in the twentieth century.

In "The Unanticipated Consequences of Purposive Social Action" (1936), Merton tried to apply a systematic analysis to the problem of unintended consequences of deliberate acts intended to cause social change. He emphasized that his term purposive action, "[was exclusively] concerned with 'conduct' as distinct from 'behavior.' That is, with action that involves motives and consequently a choice between various alternatives". Merton's usage included deviations from what Max Weber defined as rational social action: instrumentally rational and value rational. Merton also stated that "no blanket statement categorically affirming or denying the practical feasibility of all social planning is warranted."

Everyday usage

More recently, the law of unintended consequences has come to be used as an adage or idiomatic warning that an intervention in a complex system tends to create unanticipated and often undesirable outcomes.

Akin to Murphy's law, it is commonly used as a wry or humorous warning against the hubristic belief that humans can fully control the world around them, not to presuppose a belief in predestination or a lack or a disbelief in that of free will.

Causes

Possible causes of unintended consequences include the world's inherent complexity (parts of a system responding to changes in the environment), perverse incentives, human stupidity, self-deception, failure to account for human nature, or other cognitive or emotional biases. As a sub-component of complexity (in the scientific sense), the chaotic nature of the universe—and especially its quality of having small, apparently insignificant changes with far-reaching effects (e.g., the butterfly effect)—applies.

In 1936, Robert K. Merton listed five possible causes of unanticipated consequences:

  • Ignorance, making it impossible to anticipate everything, thereby leading to incomplete analysis.
  • Errors in analysis of the problem or following habits that worked in the past but may not apply to the current situation.
  • Immediate interests overriding long-term interests.
  • Basic values which may require or prohibit certain actions even if the long-term result might be unfavourable (these long-term consequences may eventually cause changes in basic values).
  • Self-defeating prophecy, or, the fear of some consequence which drives people to find solutions before the problem occurs, thus the non-occurrence of the problem is not anticipated.

In addition to Merton's causes, psychologist Stuart Vyse has noted that groupthink, described by Irving Janis, has been blamed for some decisions that result in unintended consequences.

Types

Unexpected benefits

The creation of "no-man's lands" during the Cold War, in places such as the border between Eastern and Western Europe, and the Korean Demilitarized Zone, has led to large natural habitats.

Sea life on the wreck of the sunken USS Oriskany

The sinking of ships in shallow waters during wartime has created many artificial coral reefs, which can be scientifically valuable and have become an attraction for recreational divers. This led to the deliberate sinking of retired ships for the purpose of replacing coral reefs lost to global warming and other factors.

In medicine, most drugs have unintended consequences ('side effects') associated with their use. However, some are beneficial. For instance, aspirin, a pain reliever, is also an anticoagulant that can help prevent heart attacks and reduce the severity and damage from thrombotic strokes. Beneficial side effects have also lead to off-label use –prescription or use of a drug for an unlicensed purpose. Famously, the drug Viagra was developed to lower blood pressure, with its use for treating erectile dysfunction being discovered as a side effect in clinical trials.

In papal conclave journalism, Cardinal Fridolin Ambongo Besungu of Kinshasa in the Democratic Republic of Congo, the elected leader of all the bishops of Africa (including Madagascar), by early 2024 had come to be regarded as papabile for his adroit handling of the issue of blessing same sex unions, to which he is staunchly opposed.

Unexpected drawbacks

The implementation of a profanity filter by AOL in 1996 had the unintended consequence of blocking residents of Scunthorpe, North Lincolnshire, England, from creating accounts because of a false positive. The accidental censorship of innocent language, known as the Scunthorpe problem, has been repeated and widely documented.

In 1990, the Australian state of Victoria made safety helmets mandatory for all bicycle riders. While there was a reduction in the number of head injuries, there was also an unintended reduction in the number of juvenile cyclists—fewer cyclists obviously leads to fewer injuries, all else being equal. The risk of death and serious injury per cyclist seems to have increased, possibly because of risk compensation. Research by Vulcan et al. found that the reduction in juvenile cyclists was because the youths considered wearing a bicycle helmet unfashionable. A health-benefit model developed at Macquarie University in Sydney suggests that, while helmet use reduces "the risk of head or brain injury by approximately two-thirds or more", the decrease in exercise caused by reduced cycling as a result of helmet laws is counterproductive in terms of net health.

Prohibition in the 1920s United States, originally enacted to suppress the alcohol trade, drove many small-time alcohol suppliers out of business and consolidated the hold of large-scale organized crime over the illegal alcohol industry. Since alcohol was still popular, criminal organisations producing alcohol were well-funded and hence also increased their other activities. Similarly, the war on drugs, intended to suppress the illegal drug trade, instead increased the power and profitability of drug cartels who became the primary source of the products.

In CIA jargon, "blowback" describes the unintended, undesirable consequences of covert operations, such as the funding of the Afghan Mujahideen and the destabilization of Afghanistan contributing to the rise of the Taliban and Al-Qaeda.

The introduction of exotic animals and plants for food, for decorative purposes, or to control unwanted species often leads to more harm than good done by the introduced species.

  • The introduction of rabbits in Australia and New Zealand for food was followed by an explosive growth in the rabbit population; rabbits have become a major feral pest in these countries.
  • Cane toads, introduced into Australia to control canefield pests, were unsuccessful and have become a major pest in their own right.
  • Kudzu, introduced to the US as an ornamental plant in 1876 and later used to prevent erosion in earthworks, has become a major problem in the Southeastern United States. Kudzu has displaced native plants and has effectively taken over significant portions of land.

The protection of the steel industry in the United States reduced production of steel in the United States, increased costs to users, and increased unemployment in associated industries.

Perverse results

The infamous photo of the Streisand Estate

In 2003, Barbra Streisand unsuccessfully sued Kenneth Adelman and Pictopia.com for posting a photograph of her home online. Before the lawsuit had been filed, only 6 people had downloaded the file, two of them Streisand's attorneys. The lawsuit drew attention to the image, resulting in 420,000 people visiting the site. The Streisand Effect was named after this incident, describing when an attempt to censor or remove a certain piece of information instead draws attention to the material being suppressed, resulting in the material instead becoming widely known, reported on, and distributed.

Passenger-side airbags in motorcars were intended as a safety feature, but led to an increase in child fatalities in the mid-1990s because small children were being hit by airbags that deployed automatically during collisions. The supposed solution to this problem, moving the child seat to the back of the vehicle, led to an increase in the number of children forgotten in unattended vehicles, some of whom died under extreme temperature conditions.

Risk compensation, or the Peltzman effect, occurs after implementation of safety measures intended to reduce injury or death (e.g. bike helmets, seatbelts, etc.). People may feel safer than they really are and take additional risks which they would not have taken without the safety measures in place. This may result in no change, or even an increase, in morbidity or mortality, rather than a decrease as intended.

According to an anecdote, the British government, concerned about the number of venomous cobra snakes in Delhi, offered a bounty for every dead cobra. This was a successful strategy as large numbers of snakes were killed for the reward. Eventually, enterprising people began breeding cobras for the income. When the government became aware of this, they scrapped the reward program, causing the cobra breeders to set the now-worthless snakes free. As a result, the wild cobra population further increased. The apparent solution for the problem made the situation even worse, becoming known as the Cobra effect.

Theobald Mathew's temperance campaign in 19th-century Ireland resulted in thousands of people vowing never to drink alcohol again. This led to the consumption of diethyl ether, a much more dangerous intoxicant—owing to its high flammability—by those seeking to become intoxicated without breaking the letter of their pledge.

It was thought that adding south-facing conservatories to British houses would reduce energy consumption by providing extra insulation and warmth from the sun. However, people tended to use the conservatories as living areas, installing heating and ultimately increasing overall energy consumption.

A reward for lost nets found along the Normandy coast was offered by the French government between 1980 and 1981. This resulted in people vandalizing nets to collect the reward.

Beginning in the 1940s and continuing into the 1960s, the Canadian federal government gave Quebec $2.75 per day per psychiatric patient for their cost of care, but only $1.25 a day per orphan. The perverse result is that the orphan children were diagnosed as mentally ill so Quebec could receive the larger amount of money. This psychiatric misdiagnosis affected up to 20,000 people, and the children are known as the Duplessis Orphans in reference to the Premier of Quebec who oversaw the scheme, Maurice Duplessis.

There have been attempts to curb the consumption of sugary beverages by imposing a tax on them. However, a study found that the reduced consumption was only temporary. Also, there was an increase in the consumption of beer among households.

The New Jersey Childproof Handgun Law, which was intended to protect children from accidental discharge of firearms by forcing all future firearms sold in New Jersey to contain "smart" safety features, has delayed, if not stopped entirely, the introduction of such firearms to New Jersey markets. The wording of the law caused significant public backlash, fuelled by gun rights lobbyists, and several shop owners offering such guns received death threats and stopped stocking them. In 2014, 12 years after the law was passed, it was suggested the law be repealed if gun rights lobbyists agree not to resist the introduction of "smart" firearms.

Drug prohibition can lead drug traffickers to prefer stronger, more dangerous substances, that can be more easily smuggled and distributed than other, less concentrated substances.

Televised drug prevention advertisements may lead to increased drug use.

Increasing usage of search engines, also including recent image search features, has contributed in the ease of which media is consumed. Some abnormalities in usage may have shifted preferences for pornographic film actors, as the producers began using common search queries or tags to label the actors in new roles.

The passage of the Stop Enabling Sex Traffickers Act has led to a reported increase in risky behaviors by sex workers as a result of quashing their ability to seek and screen clients online, forcing them back onto the streets or into the dark web. The ads posted were previously an avenue for advocates to reach out to those wanting to escape the trade.

The use of precision guided munitions meant to reduce the rate of civilian casualties encouraged armies to narrow their safety margins, and increase the use of deadly force in densely populated areas. This in turn increased the danger to uninvolved civilians, who in the past would have been out of the line of fire because of armies' aversion of using higher-risk weaponry in densely populated areas. The perceived ability to operate precision weaponry from afar (where in the past heavy munitions or troop deployment would have been needed) also led to the expansion of the list of potential targets. As put by Michael Walzer: "Drones not only make it possible for us to get at our enemies, they may also lead us to broaden the list of enemies, to include presumptively hostile individuals and militant organizations simply because we can get at them—even if they aren't actually involved in attacks against us." This idea is also echoed by Grégoire Chamayou: "In a situation of moral hazard, military action is very likely to be deemed 'necessary' simply because it is possible, and possible at a lower cost."

After Dobbs v. Jackson Women's Health Organization (2022) overturned Roe v. Wade (1973), the number of abortions in the United States increased and the number of births fell, due to the right to travel between states.

Other

According to Lynn White, the invention of the horse stirrup enabled new patterns of warfare that eventually led to the development of feudalism (see Stirrup Thesis).

Perverse consequences of environmental intervention

Almost all environmental problems, from chemical pollution to global warming, are the unexpected consequences of the application of modern technologies. Traffic congestion, deaths and injuries from car accidents, air pollution, and global warming are unintended consequences of the invention and large scale adoption of the automobile. Hospital infections are the unexpected side-effect of antibiotic resistance, and even human population growth leading to environmental degradation is the side effect of various technological (i.e., agricultural and industrial) revolutions.

Because of the complexity of ecosystems, deliberate changes to an ecosystem or other environmental interventions will often have (usually negative) unintended consequences. Sometimes, these effects cause permanent irreversible changes. Examples include:

Chinese poster promoting the Four Pests campaign; a boy with a red neckerchief aims a slingshot at an off-frame overhead target, and a girl next to him looks at the target as well. There is a village in the background. There is a Chinese slogan "大家都来打麻雀" in red letters at the footer.
Chinese poster encouraging children to attack sparrows
  • During the Four Pests campaign, Maoist China ordered the killing of sparrows, as well as rats, flies, and mosquitoes. The campaign was successful in reducing the sparrow population; however, in their absence, locust populations previously kept in check by sparrow predation grew out of control and came to infest crops. Rice yields were substantially decreased; the campaign was one of the causes of the Great Chinese Famine.
  • During the Great Plague of London a killing of dogs and cats was ordered. If left untouched, they would have made a significant reduction in the rat population that carried the fleas which transmitted the disease.
  • The installation of smokestacks to decrease pollution in local areas, resulting in spread of pollution at a higher altitude, and acid rain on an international scale.
  • After about 1900, public demand led the US government to fight forest fires in the American West, and set aside land as national forests and parks to protect them from fires. This policy led to fewer fires, but also led to growth conditions such that, when fires did occur, they were much larger and more damaging. Modern research suggests that this policy was misguided, and that a certain level of wildfires is a natural and important part of forest ecology.
  • Side effects of climate engineering to counter global warming could involve even further warming as a consequence of reflectivity-reducing afforestation or crop yield reductions and rebound effects after solar dimming measures with even more accelerated warming.

Nanotechnology

From Wikipedia, the free encyclopedia
Fullerene nanogears

Nanotechnology is the manipulation of matter with at least one dimension sized from 1 to 100 nanometers (nm). At this scale, commonly known as the nanoscale, surface area and quantum mechanical effects become important in describing properties of matter. This definition of nanotechnology includes all types of research and technologies that deal with these special properties. It is common to see the plural form "nanotechnologies" as well as "nanoscale technologies" to refer to research and applications whose common trait is scale. An earlier understanding of nanotechnology referred to the particular technological goal of precisely manipulating atoms and molecules for fabricating macroscale products, now referred to as molecular nanotechnology.

Nanotechnology defined by scale includes fields of science such as surface science, organic chemistry, molecular biology, semiconductor physics, energy storageengineeringmicrofabrication, and molecular engineering. The associated research and applications range from extensions of conventional device physics to molecular self-assembly, from developing new materials with dimensions on the nanoscale to direct control of matter on the atomic scale.

Nanotechnology may be able to create new materials and devices with diverse applications, such as in nanomedicine, nanoelectronics, agricultural sectorsbiomaterials energy production, and consumer products. However, nanotechnology raises issues, including concerns about the toxicity and environmental impact of nanomaterials, and their potential effects on global economics, as well as various doomsday scenarios. These concerns have led to a debate among advocacy groups and governments on whether special regulation of nanotechnology is warranted.

Origins

The concepts that seeded nanotechnology were first discussed in 1959 by physicist Richard Feynman in his talk There's Plenty of Room at the Bottom, in which he described the possibility of synthesis via direct manipulation of atoms.

Comparison of nanomaterials sizes

The term "nano-technology" was first used by Norio Taniguchi in 1974, though it was not widely known. Inspired by Feynman's concepts, K. Eric Drexler used the term "nanotechnology" in his 1986 book Engines of Creation: The Coming Era of Nanotechnology, which achieved popular success and helped thrust nanotechnology into the public sphere. In it he proposed the idea of a nanoscale "assembler" that would be able to build a copy of itself and of other items of arbitrary complexity with atom-level control. Also in 1986, Drexler co-founded The Foresight Institute to increase public awareness and understanding of nanotechnology concepts and implications.

The emergence of nanotechnology as a field in the 1980s occurred through the convergence of Drexler's theoretical and public work, which developed and popularized a conceptual framework, and experimental advances that drew additional attention to the prospects. In the 1980s, two breakthroughs helped to spark the growth of nanotechnology. First, the invention of the scanning tunneling microscope in 1981 enabled visualization of individual atoms and bonds, and was successfully used to manipulate individual atoms in 1989. The microscope's developers Gerd Binnig and Heinrich Rohrer at IBM Zurich Research Laboratory received a Nobel Prize in Physics in 1986. Binnig, Quate and Gerber also invented the analogous atomic force microscope that year.

Buckminsterfullerene C60, also known as the buckyball, is a representative member of the carbon structures known as fullerenes. Members of the fullerene family are a major subject of research falling under the nanotechnology umbrella.
Harry Kroto (top) won the 1996 Nobel Prize in Chemistry along with Richard Smalley and Robert Curl for their 1985 discovery of buckminsterfullerene, while Sumio Iijima (middle) won the inaugural 2008 Kavli Prize in Nanoscience for his 1991 discovery of carbon nanotubes.

Second, fullerenes (buckyballs) were discovered in 1985 by Harry Kroto, Richard Smalley, and Robert Curl, who together won the 1996 Nobel Prize in Chemistry. C60 was not initially described as nanotechnology; the term was used regarding subsequent work with related carbon nanotubes (sometimes called graphene tubes or Bucky tubes) which suggested potential applications for nanoscale electronics and devices. The discovery of carbon nanotubes is attributed to Sumio Iijima of NEC in 1991, for which Iijima won the inaugural 2008 Kavli Prize in Nanoscience.

In the early 2000s, the field garnered increased scientific, political, and commercial attention that led to both controversy and progress. Controversies emerged regarding the definitions and potential implications of nanotechnologies, exemplified by the Royal Society's report on nanotechnology. Challenges were raised regarding the feasibility of applications envisioned by advocates of molecular nanotechnology, which culminated in a public debate between Drexler and Smalley in 2001 and 2003.

Meanwhile, commercial products based on advancements in nanoscale technologies began emerging. These products were limited to bulk applications of nanomaterials and did not involve atomic control of matter. Some examples include the Silver Nano platform for using silver nanoparticles as an antibacterial agent, nanoparticle-based sunscreens, carbon fiber strengthening using silica nanoparticles, and carbon nanotubes for stain-resistant textiles.

Governments moved to promote and fund research into nanotechnology, such as American the National Nanotechnology Initiative, which formalized a size-based definition of nanotechnology and established research funding, and in Europe via the European Framework Programmes for Research and Technological Development.

By the mid-2000s scientific attention began to flourish. Nanotechnology roadmaps centered on atomically precise manipulation of matter and discussed existing and projected capabilities, goals, and applications.

Fundamental concepts

Nanotechnology is the science and engineering of functional systems at the molecular scale. In its original sense, nanotechnology refers to the projected ability to construct items from the bottom up making complete, high-performance products.

One nanometer (nm) is one billionth, or 10−9, of a meter. By comparison, typical carbon–carbon bond lengths, or the spacing between these atoms in a molecule, are in the range 0.12–0.15 nm, and DNA's diameter is around 2 nm. On the other hand, the smallest cellular life forms, the bacteria of the genus Mycoplasma, are around 200 nm in length. By convention, nanotechnology is taken as the scale range 1 to 100 nm, following the definition used by the American National Nanotechnology Initiative. The lower limit is set by the size of atoms (hydrogen has the smallest atoms, which have an approximately ,25 nm kinetic diameter). The upper limit is more or less arbitrary, but is around the size below which phenomena not observed in larger structures start to become apparent and can be made use of. These phenomena make nanotechnology distinct from devices that are merely miniaturized versions of an equivalent macroscopic device; such devices are on a larger scale and come under the description of microtechnology.

To put that scale in another context, the comparative size of a nanometer to a meter is the same as that of a marble to the size of the earth.

Two main approaches are used in nanotechnology. In the "bottom-up" approach, materials and devices are built from molecular components which assemble themselves chemically by principles of molecular recognition. In the "top-down" approach, nano-objects are constructed from larger entities without atomic-level control.

Areas of physics such as nanoelectronics, nanomechanics, nanophotonics and nanoionics have evolved to provide nanotechnology's scientific foundation.

Larger to smaller: a materials perspective

Image of reconstruction on a clean Gold(100) surface, as visualized using scanning tunneling microscopy. The positions of the individual atoms composing the surface are visible.

Several phenomena become pronounced as system size. These include statistical mechanical effects, as well as quantum mechanical effects, for example, the "quantum size effect" in which the electronic properties of solids alter along with reductions in particle size. Such effects do not apply at macro or micro dimensions. However, quantum effects can become significant when nanometer scales. Additionally, physical (mechanical, electrical, optical, etc.) properties change versus macroscopic systems. One example is the increase in surface area to volume ratio altering mechanical, thermal, and catalytic properties of materials. Diffusion and reactions can be different as well. Systems with fast ion transport are referred to as nanoionics. The mechanical properties of nanosystems are of interest in research.

Simple to complex: a molecular perspective

Modern synthetic chemistry can prepare small molecules of almost any structure. These methods are used to manufacture a wide variety of useful chemicals such as pharmaceuticals or commercial polymers. This ability raises the question of extending this kind of control to the next-larger level, seeking methods to assemble single molecules into supramolecular assemblies consisting of many molecules arranged in a well-defined manner.

These approaches utilize the concepts of molecular self-assembly and/or supramolecular chemistry to automatically arrange themselves into a useful conformation through a bottom-up approach. The concept of molecular recognition is important: molecules can be designed so that a specific configuration or arrangement is favored due to non-covalent intermolecular forces. The Watson–Crick basepairing rules are a direct result of this, as is the specificity of an enzyme targeting a single substrate, or the specific folding of a protein. Thus, components can be designed to be complementary and mutually attractive so that they make a more complex and useful whole.

Such bottom-up approaches should be capable of producing devices in parallel and be much cheaper than top-down methods, but could potentially be overwhelmed as the size and complexity of the desired assembly increases. Most useful structures require complex and thermodynamically unlikely arrangements of atoms. Nevertheless, many examples of self-assembly based on molecular recognition in exist in biology, most notably Watson–Crick basepairing and enzyme-substrate interactions.

Molecular nanotechnology: a long-term view

Ribosome translating DNA is a biological machine functioning as a molecular assembler. Protein domain dynamics can now be seen by neutron spin echo spectroscopy

Molecular nanotechnology, sometimes called molecular manufacturing, concerns engineered nanosystems (nanoscale machines) operating on the molecular scale. Molecular nanotechnology is especially associated with molecular assemblers, machines that can produce a desired structure or device atom-by-atom using the principles of mechanosynthesis. Manufacturing in the context of productive nanosystems is not related to conventional technologies used to manufacture nanomaterials such as carbon nanotubes and nanoparticles.

When Drexler independently coined and popularized the term "nanotechnology", he envisioned manufacturing technology based on molecular machine systems. The premise was that molecular-scale biological analogies of traditional machine components demonstrated molecular machines were possible: biology was full of examples of sophisticated, stochastically optimized biological machines.

Drexler and other researchers have proposed that advanced nanotechnology ultimately could be based on mechanical engineering principles, namely, a manufacturing technology based on the mechanical functionality of these components (such as gears, bearings, motors, and structural members) that would enable programmable, positional assembly to atomic specification. The physics and engineering performance of exemplar designs were analyzed in Drexler's book Nanosystems: Molecular Machinery, Manufacturing, and Computation.

In general, assembling devices on the atomic scale requires positioning atoms on other atoms of comparable size and stickiness. Carlo Montemagno's view is that future nanosystems will be hybrids of silicon technology and biological molecular machines. Richard Smalley argued that mechanosynthesis was impossible due to difficulties in mechanically manipulating individual molecules.

This led to an exchange of letters in the American Chemical Society publication Chemical & Engineering News in 2003. Though biology clearly demonstrates that molecular machines are possible, non-biological molecular machines remained in their infancy. Alex Zettl and colleagues at Lawrence Berkeley Laboratories and UC Berkeley constructed at least three molecular devices whose motion is controlled via changing voltage: a nanotube nanomotor, a molecular actuator, and a nanoelectromechanical relaxation oscillator.

Ho and Lee at Cornell University in 1999 used a scanning tunneling microscope to move an individual carbon monoxide molecule (CO) to an individual iron atom (Fe) sitting on a flat silver crystal and chemically bound the CO to the Fe by applying a voltage.

Research

Graphical representation of a rotaxane, useful as a molecular switch
This DNA tetrahedron is an artificially designed nanostructure of the type made in the field of DNA nanotechnology. Each edge of the tetrahedron is a 20 base pair DNA double helix, and each vertex is a three-arm junction.
Rotating view of C60, one kind of fullerene
This device transfers energy from nano-thin layers of quantum wells to nanocrystals above them, causing the nanocrystals to emit visible light.

Nanomaterials

Many areas of science develop or study materials having unique properties arising from their nanoscale dimensions.

Bottom-up approaches

The bottom-up approach seeks to arrange smaller components into more complex assemblies.

  • DNA nanotechnology utilizes Watson–Crick basepairing to construct well-defined structures out of DNA and other nucleic acids.
  • Approaches from the field of "classical" chemical synthesis (inorganic and organic synthesis) aim at designing molecules with well-defined shape (e.g. bis-peptides).
  • More generally, molecular self-assembly seeks to use concepts of supramolecular chemistry, and molecular recognition in particular, to cause single-molecule components to automatically arrange themselves into some useful conformation.
  • Atomic force microscope tips can be used as a nanoscale "write head" to deposit a chemical upon a surface in a desired pattern in a process called dip-pen nanolithography. This technique fits into the larger subfield of nanolithography.
  • Molecular-beam epitaxy allows for bottom-up assemblies of materials, most notably semiconductor materials commonly used in chip and computing applications, stacks, gating, and nanowire lasers.

Top-down approaches

These seek to create smaller devices by using larger ones to direct their assembly.

Functional approaches

Functional approaches seek to develop useful components without regard to how they might be assembled.

Biomimetic approaches

Speculative

These subfields seek to anticipate what inventions nanotechnology might yield, or attempt to propose an agenda along which inquiry could progress. These often take a big-picture view, with more emphasis on societal implications than engineering details.

  • Molecular nanotechnology is a proposed approach that involves manipulating single molecules in finely controlled, deterministic ways. This is more theoretical than the other subfields, and many of its proposed techniques are beyond current capabilities.
  • Nanorobotics considers self-sufficient machines operating at the nanoscale. There are hopes for applying nanorobots in medicine. Nevertheless, progress on innovative materials and patented methodologies have been demonstrated.
  • Productive nanosystems are "systems of nanosystems" could produce atomically precise parts for other nanosystems, not necessarily using novel nanoscale-emergent properties, but well-understood fundamentals of manufacturing. Because of the discrete (i.e. atomic) nature of matter and the possibility of exponential growth, this stage could form the basis of another industrial revolution. Mihail Roco proposed four states of nanotechnology that seem to parallel the technical progress of the Industrial Revolution, progressing from passive nanostructures to active nanodevices to complex nanomachines and ultimately to productive nanosystems.
  • Programmable matter seeks to design materials whose properties can be easily, reversibly and externally controlled though a fusion of information science and materials science.
  • Due to the popularity and media exposure of the term nanotechnology, the words picotechnology and femtotechnology have been coined in analogy to it, although these are used only informally.

Dimensionality in nanomaterials

Nanomaterials can be classified in 0D, 1D, 2D and 3D nanomaterials. Dimensionality plays a major role in determining the characteristic of nanomaterials including physical, chemical, and biological characteristics. With the decrease in dimensionality, an increase in surface-to-volume ratio is observed. This indicates that smaller dimensional nanomaterials have higher surface area compared to 3D nanomaterials. Two dimensional (2D) nanomaterials have been extensively investigated for electronic, biomedical, drug delivery and biosensor applications.

Tools and techniques

Typical AFM setup. A microfabricated cantilever with a sharp tip is deflected by features on a sample surface, much like in a phonograph but on a much smaller scale. A laser beam reflects off the backside of the cantilever into a set of photodetectors, allowing the deflection to be measured and assembled into an image of the surface.

Scanning microscopes

The atomic force microscope (AFM) and the scanning tunneling microscope (STM) are two versions of scanning probes that are used for nano-scale observation. Other types of scanning probe microscopy have much higher resolution, since they are not limited by the wavelengths of sound or light.

The tip of a scanning probe can also be used to manipulate nanostructures (positional assembly). Feature-oriented scanning may be a promising way to implement these nano-scale manipulations via an automatic algorithm. However, this is still a slow process because of low velocity of the microscope.

The top-down approach anticipates nanodevices that must be built piece by piece in stages, much as manufactured items are made. Scanning probe microscopy is an important technique both for characterization and synthesis. Atomic force microscopes and scanning tunneling microscopes can be used to look at surfaces and to move atoms around. By designing different tips for these microscopes, they can be used for carving out structures on surfaces and to help guide self-assembling structures. By using, for example, feature-oriented scanning approach, atoms or molecules can be moved around on a surface with scanning probe microscopy techniques.

Lithography

Various techniques of lithography, such as optical lithography, X-ray lithography, dip pen lithography, electron beam lithography or nanoimprint lithography offer top-down fabrication techniques where a bulk material is reduced to a nano-scale pattern.

Another group of nano-technological techniques include those used for fabrication of nanotubes and nanowires, those used in semiconductor fabrication such as deep ultraviolet lithography, electron beam lithography, focused ion beam machining, nanoimprint lithography, atomic layer deposition, and molecular vapor deposition, and further including molecular self-assembly techniques such as those employing di-block copolymers.

Bottom-up

In contrast, bottom-up techniques build or grow larger structures atom by atom or molecule by molecule. These techniques include chemical synthesis, self-assembly and positional assembly. Dual-polarization interferometry is one tool suitable for characterization of self-assembled thin films. Another variation of the bottom-up approach is molecular-beam epitaxy or MBE. Researchers at Bell Telephone Laboratories including John R. Arthur. Alfred Y. Cho, and Art C. Gossard developed and implemented MBE as a research tool in the late 1960s and 1970s. Samples made by MBE were key to the discovery of the fractional quantum Hall effect for which the 1998 Nobel Prize in Physics was awarded. MBE lays down atomically precise layers of atoms and, in the process, build up complex structures. Important for research on semiconductors, MBE is also widely used to make samples and devices for the newly emerging field of spintronics.

Therapeutic products based on responsive nanomaterials, such as the highly deformable, stress-sensitive transfersome vesicles, are approved for human use in some countries.

Applications

One of the major applications of nanotechnology is in the area of nanoelectronics with MOSFET's being made of small nanowires ≈10 nm in length.
Nanowire lasers for ultrafast transmission of information in light pulses

As of August 21, 2008, the Project on Emerging Nanotechnologies estimated that over 800 manufacturer-identified nanotech products were publicly available, with new ones hitting the market at a pace of 3–4 per week. Most applications are "first generation" passive nanomaterials that includes titanium dioxide in sunscreen, cosmetics, surface coatings, and some food products; Carbon allotropes used to produce gecko tape; silver in food packaging, clothing, disinfectants, and household appliances; zinc oxide in sunscreens and cosmetics, surface coatings, paints and outdoor furniture varnishes; and cerium oxide as a fuel catalyst.

In the electric car industry, single wall carbon nanotubes (SWCNTs) address key lithium-ion battery challenges, including energy density, charge rate, service life, and cost. SWCNTs connect electrode particles during charge/discharge process, preventing battery premature degradation. Their exceptional ability to wrap active material particles enhanced electrical conductivity and physical properties, setting them apart multi-walled carbon nanotubes and carbon black.

Further applications allow tennis balls to last longer, golf balls to fly straighter, and bowling balls to become more durable. Trousers and socks have been infused with nanotechnology to last longer and lower temperature in the summer. Bandages are infused with silver nanoparticles to heal cuts faster. Video game consoles and personal computers may become cheaper, faster, and contain more memory thanks to nanotechnology. Also, to build structures for on chip computing with light, for example on chip optical quantum information processing, and picosecond transmission of information.

Nanotechnology may have the ability to make existing medical applications cheaper and easier to use in places like the doctors' offices and at homes. Cars use nanomaterials in such ways that car parts require fewer metals during manufacturing and less fuel to operate in the future.

Nanoencapsulation involves the enclosure of active substances within carriers. Typically, these carriers offer advantages, such as enhanced bioavailability, controlled release, targeted delivery, and protection of the encapsulated substances. In the medical field, nanoencapsulation plays a significant role in drug delivery. It facilitates more efficient drug administration, reduces side effects, and increases treatment effectiveness. Nanoencapsulation is particularly useful for improving the bioavailability of poorly water-soluble drugs, enabling controlled and sustained drug release, and supporting the development of targeted therapies. These features collectively contribute to advancements in medical treatments and patient care.

Nanotechnology may play role in tissue engineering. When designing scaffolds, researchers attempt to mimic the nanoscale features of a cell's microenvironment to direct its differentiation down a suitable lineage. For example, when creating scaffolds to support bone growth, researchers may mimic osteoclast resorption pits.

Researchers used DNA origami-based nanobots capable of carrying out logic functions to target drug delivery in cockroaches.

A nano bible (a .5mm2 silicon chip) was created by the Technion in order to increase youth interest in nanotechnology.

Implications

One concern is the effect that industrial-scale manufacturing and use of nanomaterials will have on human health and the environment, as suggested by nanotoxicology research. For these reasons, some groups advocate that nanotechnology be regulated. However, regulation might stifle scientific research and the development of beneficial innovations. Public health research agencies, such as the National Institute for Occupational Safety and Health research potential health effects stemming from exposures to nanoparticles.

Nanoparticle products may have unintended consequences. Researchers have discovered that bacteriostatic silver nanoparticles used in socks to reduce foot odor are released in the wash. These particles are then flushed into the wastewater stream and may destroy bacteria that are critical components of natural ecosystems, farms, and waste treatment processes.

Public deliberations on risk perception in the US and UK carried out by the Center for Nanotechnology in Society found that participants were more positive about nanotechnologies for energy applications than for health applications, with health applications raising moral and ethical dilemmas such as cost and availability.

Experts, including director of the Woodrow Wilson Center's Project on Emerging Nanotechnologies David Rejeski, testified that commercialization depends on adequate oversight, risk research strategy, and public engagement. As of 206 Berkeley, California was the only US city to regulate nanotechnology.

Health and environmental concerns

Inhaling airborne nanoparticles and nanofibers may contribute to pulmonary diseases, e.g. fibrosis. Researchers found that when rats breathed in nanoparticles, the particles settled in the brain and lungs, which led to significant increases in biomarkers for inflammation and stress response and that nanoparticles induce skin aging through oxidative stress in hairless mice.

A two-year study at UCLA's School of Public Health found lab mice consuming nano-titanium dioxide showed DNA and chromosome damage to a degree "linked to all the big killers of man, namely cancer, heart disease, neurological disease and aging".

A Nature Nanotechnology study suggested that some forms of carbon nanotubes could be as harmful as asbestos if inhaled in sufficient quantities. Anthony Seaton of the Institute of Occupational Medicine in Edinburgh, Scotland, who contributed to the article on carbon nanotubes said "We know that some of them probably have the potential to cause mesothelioma. So those sorts of materials need to be handled very carefully." In the absence of specific regulation forthcoming from governments, Paull and Lyons (2008) have called for an exclusion of engineered nanoparticles in food. A newspaper article reports that workers in a paint factory developed serious lung disease and nanoparticles were found in their lungs.

Regulation

Calls for tighter regulation of nanotechnology have accompanied a debate related to human health and safety risks. Some regulatory agencies cover some nanotechnology products and processes – by "bolting on" nanotechnology to existing regulations – leaving clear gaps. Davies proposed a road map describing steps to deal with these shortcomings.

Andrew Maynard, chief science advisor to the Woodrow Wilson Center's Project on Emerging Nanotechnologies, reported insufficient funding for human health and safety research, and as a result inadequate understanding of human health and safety risks. Some academics called for stricter application of the precautionary principle, slowing marketing approval, enhanced labelling and additional safety data.

A Royal Society report identified a risk of nanoparticles or nanotubes being released during disposal, destruction and recycling, and recommended that "manufacturers of products that fall under extended producer responsibility regimes such as end-of-life regulations publish procedures outlining how these materials will be managed to minimize possible human and environmental exposure".

Evolutionary neuroscience

From Wikipedia, the free encyclopedia https://en.wikipedia.org/wiki/Evolutionary_neuroscience   ...