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Sustainability science emerged in the 21st century as a new academic discipline. This new field of science was officially introduced with a "Birth Statement" at the World Congress "Challenges of a Changing Earth 2001" in Amsterdam organized by the International Council for Science (ICSU), the International Geosphere-Biosphere Programme (IGBP), the International Human Dimensions Programme on Global Environmental Change and the World Climate Research Programme (WCRP). The field reflects a desire to give the generalities and broad-based approach of “sustainability” a stronger analytic and scientific underpinning as it "brings together scholarship and practice, global and local perspectives from north and south, and disciplines across the natural and social sciences, engineering, and medicine". Ecologist William C. Clark proposes that it can be usefully thought of as "neither 'basic' nor 'applied' research but as a field defined by the problems it addresses rather than by the disciplines it employs" and that it "serves the need for advancing both knowledge and action by creating a dynamic bridge between the two".

The field is focused on examining the interactions between human, environmental, and engineered systems to understand and contribute to solutions for complex challenges that threaten the future of humanity and the integrity of the life support systems of the planet, such as climate change, biodiversity loss, pollution and land and water degradation.

Sustainability science, like sustainability itself, derives some impetus from the concepts of sustainable development and environmental science.[6] Sustainability science provides a critical framework for sustainability[7] while sustainability measurement provides the evidence-based quantitative data needed to guide sustainability governance.[8]