Anticholinergics (anticholinergic agent) are a group of substances that blocks the action of the neurotransmitter called acetylcholine (ACh) at synapses in the central and peripheral nervous system.
These agents inhibit the parasympathetic nervous system by selectively blocking the binding of ACh to its receptor in nerve cells. The nerve fibers of the parasympathetic system are responsible for the involuntary movement of smooth muscles present in the gastrointestinal tract, urinary tract, lungs, sweat glands, and many other parts of the body.
In broad terms, anticholinergics are divided into two categories in accordance with their specific targets in the central and peripheral nervous system and at the neuromuscular junction: antimuscarinic agents, and antinicotinic agents (ganglionic blockers, neuromuscular blockers).
The term "anticholinergic" is typically used to refer to antimuscarinics which competitively inhibit the binding of ACh to muscarinic acetylcholine receptors; such agents do not antagonize the binding at nicotinic acetylcholine receptors at the neuromuscular junction, although the term is sometimes used to refer to agents which do so.
Medical uses
Anticholinergic drugs are used to treat a variety of conditions:
- Dizziness (including vertigo and motion sickness-related symptoms)
- Extrapyramidal symptoms, a potential side-effect of antipsychotic medications
- Gastrointestinal disorders (e.g., peptic ulcers, diarrhea, pylorospasm, diverticulitis, ulcerative colitis, nausea, and vomiting)
- Genitourinary disorders (e.g., cystitis, urethritis, and prostatitis)
- Insomnia, although usually only on a short-term basis
- Respiratory disorders (e.g., asthma, chronic bronchitis, and chronic obstructive pulmonary disease [COPD])
- Sinus bradycardia due to a hypersensitive vagus nerve
- Organophosphate based nerve agent poisoning, such as VX, sarin, tabun, and soman (atropine is favoured in conjunction with an oxime, usually pralidoxime)
Anticholinergics generally have antisialagogue effects (decreasing saliva production), and most produce some level of sedation, both being advantageous in surgical procedures.
Until the beginning of the 20th century anticholinergic drugs were widely used to treat psychiatric disorders.
Physiological effects
- Delirium
- Ocular symptoms (from eye drops): mydriasis, pupil dilation, and acute angle-closure glaucoma in those with shallow anterior chamber
- Anhidrosis, dry mouth, dry skin
- Fever
- Constipation
- Tachycardia
- Urinary retention
- Cutaneous vasodilation
Clinically the most significant feature is delirium, particularly in the elderly, who are most likely to be affected by the toxidrome.
Side effects
Long-term use may increase the risk of both cognitive and physical decline. It is unclear whether they affect the risk of death generally. However, in older adults they do appear to increase the risk of death.
Possible effects of anticholinergics include:
- Poor coordination
- Dementia
- Decreased mucus production in the nose and throat; consequent dry, sore throat
- Dry-mouth with possible acceleration of dental caries
- Cessation of sweating; consequent decreased epidermal thermal dissipation leading to warm, blotchy, or red skin
- Increased body temperature
- Pupil dilation; consequent sensitivity to bright light (photophobia)
- Loss of accommodation (loss of focusing ability, blurred vision – cycloplegia)
- Tendency to be easily startled
- Urinary retention
- Urinary incontinence while sleeping
- Diminished bowel movement, sometimes ileus (decreases motility via the vagus nerve)
- Increased intraocular pressure; dangerous for people with narrow-angle glaucoma.
Possible effects in the central nervous system resemble those associated with delirium, and may include:
- Confusion
- Disorientation
- Agitation
- Euphoria or dysphoria
- Respiratory depression
- Memory problems
- Inability to concentrate
- Wandering thoughts; inability to sustain a train of thought
- Incoherent speech
- Irritability
- Mental confusion (brain fog)
- Wakeful myoclonic jerking
- Unusual sensitivity to sudden sounds
- Illogical thinking
- Photophobia
- Visual disturbances
- Periodic flashes of light
- Periodic changes in visual field
- Visual snow
- Restricted or "tunnel vision"
- Visual, auditory, or other sensory hallucinations
- Warping or waving of surfaces and edges
- Textured surfaces
- "Dancing" lines; "spiders", insects; form constants
- Lifelike objects indistinguishable from reality
- Phantom smoking
- Hallucinated presence of people not actually there
- Rarely: seizures, coma, and death
- Orthostatic hypotension (severe drop in systolic blood pressure when standing up suddenly) and significantly increased risk of falls in the elderly population.
Older patients are at a higher risk of experiencing CNS side effects.
Toxicity
An acute anticholinergic syndrome is reversible and subsides once all of the causative agents have been excreted. Reversible acetylcholinesterase inhibitor agents such as physostigmine can be used as an antidote in life-threatening cases. Wider use is discouraged due to the significant side effects related to cholinergic excess including seizures, muscle weakness, bradycardia, bronchoconstriction, lacrimation, salivation, bronchorrhea, vomiting, and diarrhea. Even in documented cases of anticholinergic toxicity, seizures have been reported after the rapid administration of physostigmine. Asystole has occurred after physostigmine administration for tricyclic antidepressant overdose, so a conduction delay (QRS > 0.10 second) or suggestion of tricyclic antidepressant ingestion is generally considered a contraindication to physostigmine administration.
Pharmacology
Anticholinergics are classified according to the receptors that are affected:
- Antimuscarinic agents operate on the muscarinic acetylcholine receptors. The majority of anticholinergic drugs are antimuscarinics.
- Antinicotinic agents operate on the nicotinic acetylcholine receptors. The majority of these are non-depolarising skeletal muscle relaxants for surgical use that are structurally related to curare. Several are depolarizing agents.
Examples
Examples of common anticholinergics:
- Antimuscarinic agents
- Antipsychotics (clozapine, quetiapine)
- Atropine
- Benztropine
- Biperiden
- Chlorpheniramine
- Certain SSRIs (Paroxetine)
- Dicyclomine (Dicycloverine)
- Dimenhydrinate
- Diphenhydramine
- Doxepin
- Doxylamine
- Glycopyrrolate
- Glycopyrronium
- Hyoscyamine
- Ipratropium
- Orphenadrine
- Oxitropium
- Oxybutynin
- Promethazine
- Propantheline bromide
- Scopolamine
- Solifenacin
- Tolterodine
- Tiotropium
- Tricyclic antidepressants (28 compounds with numerous trade names)
- Trihexyphenidyl
- Tropicamide
- Umeclidinium
- Antinicotinic agents
- Bupropion – Ganglion blocker
- Dextromethorphan - Cough suppressant and ganglion blocker
- Doxacurium – Nondepolarizing skeletal muscular relaxant
- Hexamethonium – Ganglion blocker
- Mecamylamine – Ganglion blocker and occasional smoking cessation aid
- Tubocurarine - Nondepolarizing skeletal muscular relaxant
Plants of the family Solanaceae contain various anticholinergic tropane alkaloids, such as scopolamine, atropine, and hyoscyamine.
Physostigmine is one of only a few drugs that can be used as an antidote for anticholinergic poisoning. Nicotine also counteracts anticholinergics by activating nicotinic acetylcholine receptors. Caffeine (although an adenosine receptor antagonist) can counteract the anticholinergic symptoms by reducing sedation and increasing acetylcholine activity, thereby causing alertness and arousal.
Recreational uses
When a significant amount of an anticholinergic is taken into the body, a toxic reaction known as acute anticholinergic syndrome may result. This may happen accidentally or intentionally as a consequence of recreational drug use. Anticholinergic drugs are usually considered the least enjoyable by many recreational drug users. In the context of recreational use, anticholinergics are often called deliriants.
Plant sources
The most common plants containing anticholinergic alkaloids (including atropine, scopolamine, and hyoscyamine among others) are:
- Atropa belladonna (deadly nightshade)
- Brugmansia species
- Datura species
- Garrya species
- Hyoscyamus niger (henbane)
- Mandragora officinarum (mandrake)
Use as a deterrent
Several narcotic and opiate-containing drug preparations, such as those containing hydrocodone and codeine are combined with an anticholinergic agent to deter intentional misuse. Examples include Hydromet/Hycodan (hydrocodone/homatropine), Lomotil (diphenoxylate/atropine) and Tussionex (hydrocodone polistirex/chlorpheniramine). However, it is noted that opioid/antihistamine combinations are used clinically for their synergistic effect in the management of pain and maintenance of dissociative anesthesia (sedation) in such preparations as Meprozine (meperidine/promethazine) and Diconal (dipipanone/cyclizine), which act as strong anticholinergic agents.
