From Wikipedia, the free encyclopedia
A widespread
endemic disease that is stable in terms of how many people are getting sick from it is not a pandemic. Further,
flu pandemics generally exclude recurrences of
seasonal flu. Throughout history, there have been a number of pandemics, such as
smallpox and
tuberculosis. One of the most devastating pandemics was the
Black Death, which killed over 75 million people in 1350. The most recent pandemics include the
HIV pandemic as well as the
1918 and
2009 H1N1 pandemics.
Definition and stages
Advice
(in French and English) for travelers on risks of epidemics abroad.
Posters from the Charles De Gaulle airport, Paris, 2016.
A pandemic is an
epidemic occurring on a scale which crosses international boundaries, usually affecting a large number of people.
Pandemics can also occur in important agricultural organisms
(livestock, crop plants, fish, tree species) or in other organisms.
The
World Health Organization
(WHO) has a six-stage classification that describes the process by
which a novel influenza virus moves from the first few infections in
humans through to a pandemic. This starts with the virus mostly
infecting animals, with a few cases where animals infect people, then
moves through the stage where the virus begins to spread directly
between people, and ends with a pandemic when infections from the new
virus have spread worldwide and it will be out of control until we stop
it.
A disease or condition is not a pandemic merely because it is
widespread or kills many people; it must also be infectious. For
instance,
cancer is responsible for many deaths but is not considered a pandemic because the disease is not infectious or contagious.
In a virtual press conference in May 2009 on the influenza pandemic, Dr Keiji Fukuda, Assistant Director-General ad interim
for Health Security and Environment, WHO said "An easy way to think
about pandemic … is to say: a pandemic is a global outbreak. Then you
might ask yourself: 'What is a global outbreak'? Global outbreak means
that we see both spread of the agent … and then we see disease
activities in addition to the spread of the virus."
In planning for a possible influenza pandemic, the WHO published a
document on pandemic preparedness guidance in 1999, revised in 2005 and
in February 2009, defining phases and appropriate actions for each
phase in an aide memoir entitled
WHO pandemic phase descriptions and main actions by phase.
The 2009 revision, including definitions of a pandemic and the phases
leading to its declaration, were finalized in February 2009. The
pandemic H1N1 2009 virus was neither on the horizon at that time nor
mentioned in the document. All versions of this document refer to influenza. The phases are defined by the spread of the disease;
virulence and
mortality are not mentioned in the current WHO definition, although these factors have previously been included.
Current pandemics
HIV and AIDS
HIV originated in Africa, and spread to the United States via Haiti between 1966 and 1972.
AIDS
is currently a pandemic, with infection rates as high as 25% in
southern and eastern Africa. In 2006, the HIV prevalence rate among
pregnant women in
South Africa was 29.1%. Effective education about safer sexual practices and
bloodborne infection
precautions training have helped to slow down infection rates in
several African countries sponsoring national education programs.
Infection rates are rising again in Asia and the Americas. The AIDS
death toll in
Africa may reach 90–100 million by 2025.
Pandemics and notable epidemics through history
There have been a number of significant pandemics recorded in human
history, generally
zoonoses which came about with
domestication of animals, such as
influenza
and tuberculosis. There have been a number of particularly significant
epidemics that deserve mention above the "mere" destruction of cities:
- Plague of Athens, 430 BC. Possibly typhoid fever
killed a quarter of the Athenian troops, and a quarter of the
population over four years. This disease fatally weakened the dominance
of Athens,
but the sheer virulence of the disease prevented its wider spread; i.e.
it killed off its hosts at a rate faster than they could spread it. The
exact cause of the plague was unknown for many years. In January 2006,
researchers from the University of Athens analyzed teeth recovered from a mass grave underneath the city, and confirmed the presence of bacteria responsible for typhoid.
Bubonic plague victims in a mass grave from 1720–1721 in Martigues, France
- Antonine Plague,
165–180 AD. Possibly smallpox brought to the Italian peninsula by
soldiers returning from the Near East; it killed a quarter of those
infected, and up to five million in all. At the height of a second outbreak, the Plague of Cyprian (251–266), which may have been the same disease, 5,000 people a day were said to be dying in Rome.
- Plague of Justinian, from 541 to 750, was the first recorded outbreak of the bubonic plague. It started in Egypt, and reached Constantinople the following spring, killing (according to the Byzantine chronicler Procopius)
10,000 a day at its height, and perhaps 40% of the city's inhabitants.
The plague went on to eliminate a quarter to a half of the human population that it struck throughout the known world. It caused Europe's population to drop by around 50% between 550 and 700.
- Black Death, from 1331 to 1353. The total number of deaths worldwide is estimated at 75 million people. Eight hundred years after the last outbreak, the plague returned to Europe. Starting in Asia, the disease reached Mediterranean and western Europe in 1348 (possibly from Italian merchants fleeing fighting in Crimea), and killed an estimated 20 to 30 million Europeans in six years; a third of the total population, and up to a half in the worst-affected urban areas. It was the first of a cycle of European plague epidemics that continued until the 18th century. There were more than 100 plague epidemics in Europe in this period. The disease recurred in England every two to five years from 1361 to 1480. By the 1370s, England's population was reduced by 50%. The Great Plague of London of 1665–66 was the last major outbreak of the plague in England. The disease killed approximately 100,000 people, 20% of London's population.
- The third plague pandemic started in China in 1855, and spread to India, where 10 million people died. During this pandemic, the United States saw its first outbreak: the San Francisco plague of 1900–1904. Today, isolated cases of plague are still found in the western United States.
Encounters between European explorers and populations in the rest of
the world often introduced local epidemics of extraordinary virulence.
Disease killed part of the native population of the
Canary Islands in the 16th century (
Guanches). Half the native population of
Hispaniola in 1518 was killed by smallpox.
Smallpox also ravaged
Mexico in the 1520s, killing 150,000 in
Tenochtitlán alone, including the emperor, and
Peru in the 1530s, aiding the European conquerors.
Measles killed a further two million Mexican natives in the 17th century. In 1618–1619, smallpox wiped out 90% of the
Massachusetts Bay Native Americans. During the 1770s, smallpox killed at least 30% of the
Pacific Northwest Native Americans. Smallpox epidemics in
1780–1782 and
1837–1838 brought devastation and drastic depopulation among the
Plains Indians. Some believe that the death of up to 95% of the
Native American population of the
New World was caused by
Old World diseases such as smallpox, measles, and influenza. Over the centuries, the Europeans had developed high degrees of
immunity to these diseases, while the
indigenous peoples had no such immunity.
Smallpox devastated the native population of
Australia, killing around 50% of
Indigenous Australians in the early years of British colonization. It also killed many
New Zealand Māori. As late as 1848–49, as many as 40,000 out of 150,000
Hawaiians are estimated to have died of
measles,
whooping cough and
influenza. Introduced diseases, notably smallpox, nearly wiped out the native population of
Easter Island. In 1875, measles killed over 40,000
Fijians, approximately one-third of the population. The disease devastated the
Andamanese population.
Ainu population decreased drastically in the 19th century, due in large part
to infectious diseases brought by Japanese settlers pouring into
Hokkaido.
Researchers concluded that
syphilis was carried from the New World to Europe after
Columbus'
voyages. The findings suggested Europeans could have carried the
nonvenereal tropical bacteria home, where the organisms may have mutated
into a more deadly form in the different conditions of Europe. The disease was more frequently fatal than it is today. Syphilis was a major killer in Europe during the
Renaissance. Between 1602 and 1796, the
Dutch East India Company
sent almost a million Europeans to work in Asia. Ultimately, only less
than one-third made their way back to Europe. The majority died of
diseases. Disease killed more British soldiers in India than war.
As early as 1803, the
Spanish Crown organized a mission (the
Balmis expedition) to transport the
smallpox vaccine to the
Spanish colonies, and establish mass vaccination programs there. By 1832, the federal government of the United States established a smallpox vaccination program for Native Americans.
From the beginning of the 20th century onward, the elimination or
control of disease in tropical countries became a driving force for all
colonial powers. The
sleeping sickness epidemic in Africa was arrested due to mobile teams systematically screening millions of people at risk. In the 20th century, the world saw the biggest increase in its
population in human history due to lessening of the
mortality rate in many countries due to
medical advances. The
world population has grown from 1.6 billion in 1900 to an estimated 7 billion today.
Cholera
Since it became widespread in the 19th century, cholera has killed tens of millions of people.
- 1817–1824 cholera pandemic. Previously restricted to the Indian subcontinent, the pandemic began in Bengal, then spread across India by 1820. 10,000 British troops and countless Indians died during this pandemic. It extended as far as China, Indonesia (where more than 100,000 people succumbed on the island of Java alone) and the Caspian Sea
before receding. Deaths in the Indian subcontinent between 1817 and
1860 are estimated to have exceeded 15 million persons. Another 23
million died between 1865 and 1917. Russian deaths during a similar period exceeded 2 million.
- 1826–1837 cholera pandemic. Reached Russia, Hungary (about 100,000 deaths) and Germany in 1831, London in 1832 (more than 55,000 persons died in the United Kingdom]]), France, Canada (Ontario), and United States (New York City) in the same year,
and the Pacific coast of North America by 1834. It is believed that
over 150,000 Americans died of cholera between 1832 and 1849.
- 1846–1860 cholera pandemic.
Deeply affected Russia, with over a million deaths. A two-year outbreak
began in England and Wales in 1848 and claimed 52,000 lives. Throughout Spain, cholera caused more than 236,000 deaths in 1854–55. It claimed 200,000 lives in Mexico.
- 1863–75 cholera pandemic. Spread mostly in Europe and Africa. At least 30,000 of the 90,000 Mecca pilgrims fell victim to the disease. Cholera claimed 90,000 lives in Russia in 1866.
- In 1866, there was an outbreak in North America. It killed some 50,000 Americans.
- 1881–96 cholera pandemic. The 1883–1887 epidemic cost 250,000 lives in Europe and at least 50,000 in the Americas. Cholera claimed 267,890 lives in Russia (1892); 120,000 in Spain; 90,000 in Japan and 60,000 in Persia.
- In 1892, cholera contaminated the water supply of Hamburg, and caused 8,606 deaths.
- 1899–1923 cholera pandemic. Had little effect in Europe because of advances in public health, but Russia was badly affected again (more than 500,000 people dying of cholera during the first quarter of the 20th century). The sixth pandemic killed more than 800,000 in India. The 1902–1904 cholera epidemic claimed over 200,000 lives in the Philippines.
- 1961–75 cholera pandemic. Began in Indonesia, called El Tor after the new biotype responsible for the pandemic, and reached Bangladesh in 1963, India in 1964, and the USSR in 1966. Since then the pandemic has reached Africa, South America, and central America.
Influenza
- The Greek physician Hippocrates, the "Father of Medicine", first described influenza in 412 BC.
- The first influenza pandemic was recorded in 1580, and since then, influenza pandemics occurred every 10 to 30 years.
- The 1889–1890 flu pandemic, also known as Russian Flu, was first reported in May 1889 in Bukhara, Uzbekistan. By October, it had reached Tomsk and the Caucasus. It rapidly spread west and hit North America in December 1889, South America in February–April 1890, India in February–March 1890, and Australia in March–April 1890. The H3N8 and H2N2 subtypes of the Influenza A virus have each been identified as possible causes. It had a very high attack and mortality rate, causing around a million fatalities.
- The "Spanish flu", 1918–1919. First identified early in March 1918 in US troops training at Camp Funston, Kansas.
By October 1918, it had spread to become a worldwide pandemic on all
continents, and eventually infected about one-third of the world's population (or ≈ 500 million persons).
Unusually deadly and virulent, it ended nearly as quickly as it began,
vanishing completely within 18 months. In six months, some 50 million
were dead; some estimates put the total of those killed worldwide at over twice that number. About 17 million died in India, 675,000 in the United States and 200,000 in the UK. The virus was recently reconstructed by scientists at the CDC studying remains preserved by the Alaskan permafrost. The H1N1 virus has a small, but crucial structure that is similar to the Spanish Flu.
- The "Asian Flu",
1957–58. An H2N2 virus caused about 70,000 deaths in the United States.
First identified in China in late February 1957, the Asian flu spread
to the United States by June 1957. It caused about 2 million deaths
globally.
- The "Hong Kong Flu",
1968–69. An H3N2 caused about 34,000 deaths in the United States. This
virus was first detected in Hong Kong in early 1968, and spread to the
United States later that year. This pandemic of 1968 and 1969 killed
approximately one million people worldwide
. Influenza A (
H3N2) viruses still circulate today.
Typhus
Typhus
is sometimes called "camp fever" because of its pattern of flaring up
in times of strife. (It is also known as "gaol fever" and "ship fever",
for its habits of spreading wildly in cramped quarters, such as jails
and ships.) Emerging during the
Crusades, it had its first impact in Europe in 1489, in Spain. During fighting between the Christian Spaniards and the Muslims in
Granada, the Spanish lost 3,000 to war casualties, and 20,000 to typhus. In 1528, the French lost 18,000 troops in
Italy, and lost supremacy in Italy to the Spanish. In 1542, 30,000 soldiers died of typhus while fighting the
Ottomans in the Balkans.
During the
Thirty Years' War (1618–1648), about 8 million Germans were killed by bubonic plague and typhus. The disease also played a major role in the destruction of
Napoleon's
Grande Armée in Russia in 1812. During the retreat from Moscow, more French military personnel died of
typhus than were killed by the Russians. Of the 450,000 soldiers who crossed the
Neman
on 25 June 1812, fewer than 40,000 returned. More military personnel
were killed from 1500–1914 by typhus than from military action.
In early 1813, Napoleon raised a new army of 500,000 to replace his
Russian losses. In the campaign of that year, over 219,000 of Napoleon's
soldiers died of typhus. Typhus played a major factor in the
Irish Potato Famine. During
World War I, typhus epidemics killed over 150,000 in
Serbia. There were about 25 million infections and 3 million deaths from
epidemic typhus
in
Russia from 1918 to 1922. Typhus also killed numerous prisoners in the
Nazi concentration camps and Soviet prisoner of war camps during World War II. More than 3.5 million
Soviet POWs died out of the 5.7 million in Nazi custody.
Smallpox
Smallpox was a contagious disease caused by the
variola virus. The disease killed an estimated 400,000 Europeans per year during the closing years of the 18th century. During the 20th century, it is estimated that smallpox was responsible for 300–500 million deaths. As recently as the early 1950s, an estimated 50 million cases of smallpox occurred in the world each year. After successful
vaccination
campaigns throughout the 19th and 20th centuries, the WHO certified the
eradication of smallpox in December 1979. To this day, smallpox is the
only human infectious disease to have been completely eradicated, and
one of two infectious viruses ever to be eradicated.
Measles
Historically,
measles was prevalent throughout the world, as it is highly contagious. According to the U.S.
National Immunization Program,
90% of people were infected with measles by age 15. Before the vaccine
was introduced in 1963, there were an estimated 3–4 million
cases in the U.S. each year. Measles killed around 200 million people worldwide over the last 150 years. In 2000 alone, measles killed some 777,000 worldwide out of 40 million cases globally.
Measles is an
endemic disease,
meaning that it has been continually present in a community, and many
people develop resistance. In populations that have not been exposed to
measles, exposure to a new disease can be devastating. In 1529, a
measles outbreak in
Cuba killed two-thirds of the natives who had previously survived smallpox. The disease had ravaged
Mexico,
Central America, and the
Inca civilization.
Tuberculosis
One-third of the
world's current population has been infected with
Mycobacterium tuberculosis, and new infections occur at a rate of one per second.
About 5–10% of these latent infections will eventually progress to
active disease, which, if left untreated, kills more than half of its
victims. Annually, 8 million people become ill with tuberculosis, and 2
million people die from the disease worldwide. In the 19th century, tuberculosis killed an estimated one-quarter of the adult population of Europe;
by 1918, one in six deaths in France were still caused by tuberculosis.
During the 20th century, tuberculosis killed approximately 100 million
people. TB is still one of the most important health problems in the developing world.
Leprosy
Historically, leprosy has affected people since at least 600 BC. Leprosy outbreaks began to occur in Western Europe around 1000 AD. Numerous
leprosaria, or
leper hospitals, sprang up in the Middle Ages;
Matthew Paris estimated that in the early 13th century, there were 19,000 of them across Europe.
Malaria
Malaria is widespread in
tropical and subtropical regions, including parts of the
Americas,
Asia, and
Africa. Each year, there are approximately 350–500 million cases of malaria.
Drug resistance
poses a growing problem in the treatment of malaria in the 21st
century, since resistance is now common against all classes of
antimalarial drugs, except for the
artemisinins.
Malaria was once common in most of Europe and
North America, where it is now for all purposes non-existent. Malaria may have contributed to the decline of the
Roman Empire. The disease became known as "
Roman fever".
Plasmodium falciparum became a real threat to colonists and
indigenous people alike when it was introduced into the Americas along with the
slave trade. Malaria devastated the
Jamestown colony and regularly ravaged the South and Midwest of the United States. By 1830, it had reached the Pacific Northwest. During the
American Civil War, there were over 1.2 million cases of malaria among
soldiers of both sides. The southern U.S. continued to be afflicted with millions of cases of malaria into the 1930s.
Yellow fever
Yellow fever has been a source of several devastating epidemics. Cities as far north as New York, Philadelphia, and Boston were hit with epidemics. In 1793, one of the largest
yellow fever epidemics
in U.S. history killed as many as
5,000 people in Philadelphia—roughly 10% of the population. About half
of the residents had fled the city, including President George
Washington. In colonial times, West Africa became known as "the white man's grave" because of malaria and yellow fever.
Concern about possible future pandemics
Viral hemorrhagic fevers
Viral hemorrhagic fevers such as
Ebola virus disease,
Lassa fever virus,
Rift Valley fever,
Marburg virus and
Bolivian hemorrhagic fever
are highly contagious and deadly diseases, with the theoretical
potential to become pandemics. Their ability to spread efficiently
enough to cause a pandemic is limited, however, as transmission of these
viruses requires close contact with the infected
vector,
and the vector only has a short time before death or serious illness.
Furthermore, the short time between a vector becoming infectious and the
onset of symptoms allows medical professionals to quickly
quarantine
vectors, and prevent them from carrying the pathogen elsewhere. Genetic
mutations could occur, which could elevate their potential for causing
widespread harm; thus close observation by contagious disease
specialists is merited.
Antibiotic resistance
Antibiotic-resistant microorganisms, sometimes referred to as "
superbugs", may contribute to the re-emergence of diseases which are currently well controlled.
For example, cases of tuberculosis that are resistant to traditionally
effective treatments remain a cause of great concern to health
professionals. Every year, nearly half a million new cases of
multidrug-resistant tuberculosis (MDR-TB) are estimated to occur worldwide. China and India have the highest rate of multidrug-resistant TB. The
World Health Organization
(WHO) reports that approximately 50 million people worldwide are
infected with MDR TB, with 79 percent of those cases resistant to three
or more antibiotics. In 2005, 124 cases of
MDR TB were reported in the United States. Extensively drug-resistant tuberculosis (
XDR TB)
was identified in Africa in 2006, and subsequently discovered to exist
in 49 countries, including the United States. There are about 40,000 new
cases of XDR-TB per year, the WHO estimates.
In the past 20 years, common bacteria including
Staphylococcus aureus,
Serratia marcescens and
Enterococcus, have developed resistance to various
antibiotics such as
vancomycin, as well as whole classes of antibiotics, such as the
aminoglycosides and
cephalosporins.
Antibiotic-resistant organisms have become an important cause of
healthcare-associated (nosocomial) infections (HAI). In addition,
infections caused by community-acquired strains of methicillin-resistant
Staphylococcus aureus (
MRSA) in otherwise healthy individuals have become more frequent in recent years.
SARS
In 2003 the Italian physician
Carlo Urbani (1956–2003) was the first to identify severe acute respiratory syndrome (
SARS) as a new and dangerously contagious disease, although he became infected and died. It is caused by a
corona virus dubbed
SARS-CoV. Rapid action by national and international health authorities such as the
World Health Organization
helped to slow transmission and eventually broke the chain of
transmission, which ended the localized epidemics before they could
become a pandemic. However, the disease has not been eradicated. It
could re-emerge. This warrants monitoring and reporting of suspicious
cases of atypical pneumonia.
Influenza
Wild aquatic birds are the natural hosts for a range of
influenza
A viruses. Occasionally, viruses are transmitted from these species to
other species, and may then cause outbreaks in domestic poultry or,
rarely, in humans.
H5N1 (Avian Flu)
In February 2004,
avian influenza virus was detected in birds in
Vietnam,
increasing fears of the emergence of new variant strains. It is feared
that if the avian influenza virus combines with a human influenza virus
(in a bird or a human), the new subtype created could be both highly
contagious and highly lethal in humans. Such a subtype could cause a
global influenza pandemic, similar to the
Spanish Flu, or the lower mortality pandemics such as the
Asian Flu and the
Hong Kong Flu.
From October 2004 to February 2005, some 3,700 test kits of the 1957
Asian Flu virus were accidentally spread around the world from a lab in the US.
In May 2005, scientists urgently called upon nations to prepare
for a global influenza pandemic that could strike as much as 20% of the
world's population.
In October 2005, cases of the avian flu (the deadly strain
H5N1) were identified in
Turkey.
EU Health Commissioner Markos Kyprianou said: "We have received now
confirmation that the virus found in Turkey is an avian flu H5N1 virus.
There is a direct relationship with viruses found in Russia, Mongolia
and China." Cases of bird flu were also identified shortly thereafter in
Romania, and then
Greece. Possible cases of the virus have also been found in
Croatia,
Bulgaria and the United Kingdom.
By November 2007, numerous confirmed cases of the
H5N1 strain had been identified across Europe.
However, by the end of October, only 59 people had died as a result of
H5N1, which was atypical of previous influenza pandemics.
Avian flu cannot yet be categorized as a "pandemic", because the
virus cannot yet cause sustained and efficient human-to-human
transmission. Cases so far are recognized to have been transmitted from
bird to human, but as of December 2006, there have been very few (if
any) cases of proven human-to-human transmission.
Regular influenza viruses establish infection by attaching to receptors
in the throat and lungs, but the avian influenza virus can only attach
to receptors located deep in the lungs of humans, requiring close,
prolonged contact with infected patients, and thus limiting
person-to-person transmission.
Zika virus
An outbreak of
Zika virus
began in 2015 and strongly intensified throughout the start of 2016,
with over 1.5 million cases across more than a dozen countries in
the Americas.
The World Health Organisation warned that Zika had the potential to
become an explosive global pandemic if the outbreak was not controlled.
Economic consequences of pandemic events
In
2016, the Commission on a Global Health Risk Framework for the Future
estimated that pandemic disease events would cost the global economy
over $6 trillion in the 21st century - over $60 billion per year.
The same report also recommended spending $4.5 billion annually on
global prevention and response capabilities to reduce the threat posed
by pandemic events.
Biological warfare
In 1346, the bodies of Mongol warriors who had died of plague were thrown over the walls of the besieged
Crimean city of
Kaffa (now
Theodosia). After a protracted siege, during which the
Mongol army under
Jani Beg
was suffering the disease, they catapulted the infected corpses over
the city walls to infect the inhabitants. It has been speculated that
this operation may have been responsible for the arrival of the
Black Death in Europe.
The
Native American population was devastated after contact with the
Old World by introduction of many fatal diseases. In a well documented case of germ warfare involving British commander
Jeffery Amherst and Swiss-British officer Colonel
Henry Bouquet,
their correspondence included a proposal and agreement to give
smallpox-infected blankets to Indians in order to "Extirpate this
Execrable Race". During the
siege of Fort Pitt late in the
French and Indian War, as recorded in his journal by sundries trader and militia Captain,
William Trent,
on June 24, 1763, dignitaries from the Delaware tribe met with Fort
Pitt officials, warned them of "great numbers of Indians" coming to
attack the fort, and pleaded with them to leave the fort while there was
still time. The commander of the fort refused to abandon the fort.
Instead, the British gave as gifts two blankets, one silk handkerchief
and one linen from the smallpox hospital to two Delaware Indian
dignitaries.
A devastating smallpox epidemic plagued Native American tribes in the
Ohio Valley and Great Lakes area through 1763 and 1764, but the
effectiveness of individual instances of biological warfare remains
unknown. After extensive review of surviving documentary evidence,
historian
Francis Jennings concluded the attempt at biological warfare was "unquestionably effective at Fort Pitt"; Smallpox after
Pontiac's Rebellion killed 400,000–500,000 (possibly even up to 1.5 million) Native Americans.
During the
Sino-Japanese War (1937–1945),
Unit 731 of the
Imperial Japanese Army conducted
human experimentation
on thousands, mostly Chinese. In military campaigns, the Japanese army
used biological weapons on Chinese soldiers and civilians. Plague fleas,
infected clothing, and infected supplies encased in bombs were dropped
on various targets. The resulting
cholera,
anthrax, and plague were estimated to have killed around 400,000 Chinese civilians.
Diseases considered for or known to be used as a weapon include
anthrax,
ebola,
Marburg virus, plague,
cholera,
typhus,
Rocky Mountain spotted fever,
tularemia,
brucellosis,
Q fever,
machupo,
Coccidioides mycosis,
Glanders,
Melioidosis,
Shigella,
Psittacosis,
Japanese B encephalitis,
Rift Valley fever,
yellow fever, and smallpox.
Spores of weaponized anthrax were accidentally released from a military facility near the Soviet
closed city of
Sverdlovsk in 1979. The
Sverdlovsk anthrax leak is sometimes called "biological
Chernobyl". In January 2009, an
Al-Qaeda training camp in
Algeria
was reportedly wiped out by the plague, killing approximately 40
Islamic extremists. Some experts said that the group was developing
biological weapons,
however, a couple of days later the Algerian Health Ministry flatly
denied this rumour stating "No case of plague of any type has been
recorded in any region of
Algeria since 2003".
In popular culture
Pandemics appear in multiple fiction works. A common use is in
disaster films, where the protagonists must avoid the effects of the plague, for example
zombies.
Literature
- The Decameron, a 14th-century writing by Italian author Giovanni Boccaccio, circa 1353
- The Last Man, an 1826 novel by Mary Shelley
- Pale Horse, Pale Rider, a 1939 short novel by Katherine Anne Porter
- The Plague, a 1947 novel by Albert Camus
- Earth Abides, a 1949 novel by George R. Stewart
- I Am Legend, a 1954 science fiction/horror novel by American writer Richard Matheson
- The Andromeda Strain, a 1969 science fiction novel by Michael Crichton
- The Last Canadian, a 1974 novel by William C. Heine
- The Black Death, a 1977 novel by Gwyneth Cravens describing an outbreak of the Pneumonic plague in New York[134]
- The Stand, a 1978 novel by Stephen King
- And the Band Played On, a 1987 non-fiction account by Randy Shilts about the emergence and discovery of the HIV / AIDS pandemic
- Doomsday Book, a 1992 time-travel novel by Connie Willis
- The Last Town on Earth, a 2006 novel by Thomas Mullen
- World War Z, a 2006 novel by Max Brooks
- Company of Liars (2008), by Karen Maitland
- The Passage trilogy by Justin Cronin with The Passage (2010), The Twelve (2012), and The City of Mirrors (2016)
- Station Eleven, a 2014 novel by Emily St. John Mandel.
Film
- The Seventh Seal (1957), set during the black death
- The Last Man on Earth (1964), a horror/science fiction film based on the Richard Matheson novel I Am Legend
- The Omega Man (1971), an English science fiction film, based on the Richard Matheson novel I Am Legend
- Survivors (1975 TV series), a BBC TV series created by Terry Nation about a worldwide plague
- And the Band Played On (film) (1993), a HBO movie about the emergence of the HIV / AIDS pandemic; based on the 1987 novel by Randy Shilts
- The Stand (1994), based on the eponymous novel by Stephen King about a worldwide pandemic of biblical proportions
- The Horseman on the Roof (Le Hussard sur le Toit) (1995), a French film dealing with an 1832 cholera outbreak
- Twelve Monkeys (1995), set in a future world devastated by a man-made virus
- Outbreak (1995), fiction film focusing on an outbreak of an Ebola-like virus in Zaire and later in a small town in the United States
- Smallpox 2002 (2002), a fictional BBC docudrama
- 28 Days Later (2002), a fictional horror film following the outbreak of an infectious 'Rage' virus that destroys all of mainland Britain
- End Day (2005), a fictional BBC docudrama
- I Am Legend (2007), a horror film starring Will Smith based on the Richard Matheson novel I Am Legend
- 28 Weeks Later (2007), the sequel film to 28 Days Later, ending with the evident spread of infection to mainland Europe
- Doomsday (2008), in which Scotland is quarantined following an epidemic
- Daybreakers (2009), a horror film set 2019 in which a plague transforms most of the world's population into vampires
- After Armageddon (2010), fictional History Channel docudrama
- Contagion
(2011), American thriller centering on the threat posed by a deadly
disease and an international team of doctors contracted by the CDC to
deal with the outbreak
- Halo: Pandemic (2009–2012), a popular Machinima Web series
- World War Z (2013), apocalyptic zombie film based on the 2006 novel of the same name by Max Brooks
- Dawn of the Planet of the Apes (2014), in which a virus makes apes smarter but also wipes out over 90% of the human population at the prologue of the movie
Television
- Helix
(2014–2015), a television series that depicts a team of scientists from
the Centers for Disease Control and Prevention who are tasked to
prevent pandemics from occurring.
- The Last Man on Earth (2015–), a television series about a group of survivors after a pandemic has wiped out most life (humans and animals) on Earth
- 12 Monkeys (2015–), a television series that depicts James Cole, a time traveler, who travels from the year 2043 to the present day to stop the release of a deadly virus.
- Survivors
(1975–1977), classic BBC series created by Terry Nation. The series
follows a group of people as they come to terms with the aftermath of a
world pandemic.
- Survivors (2008),
BBC series, loosely based on the Terry Nation book that came after the
series, instead of a retelling of the original TV series.
- The Last Train 1999 written by Matthew Graham
Games
- Pandemic
(2008), a cooperative board game in which the players have to discover
the cures for four diseases that break out at the same time.
- Plague Inc. (2012), a smartphone game clone from Ndemic Creations, copied from the original Pandemic Web browser Flash game from Dark Realm Studios
- The Last of Us (2013), a post-apocalyptic survival game on PS3 and PS4 by Naughty Dog.
- Tom Clancy's The Division (2015) A video game about a bioterrorist attack that has devastated the United States and thrown New York into anarchy.
