Search This Blog

Sunday, February 17, 2019

Isaac Asimov

From Wikipedia, the free encyclopedia

Isaac Asimov
Isaac.Asimov01.jpg
BornIsaak Azimov
c. January 2, 1920
Petrovichi, Klimovichskiy Uyezd,
Russian SFSR
DiedApril 6, 1992 (aged 72)
Brooklyn, New York City, U.S.
OccupationWriter, professor of biochemistry
NationalityRussian (early years), American
Education
Alma materColumbia University
GenreScience fiction (hard SF, social SF), mystery
SubjectPopular science, science textbooks, essays, literary criticism
Literary movementGolden Age of Science Fiction
Years active1939–1992
Spouse
Children2
Signature
Scientific career
FieldsBiochemistry
InstitutionsBoston University
ThesisThe kinetics of the reaction inactivation of tyrosinase during its catalysis of the aerobic oxidation of catechol (1948)
Doctoral advisorCharles Reginald Dawson
Other academic advisorsRobert Elderfield (post-doctoral)

Isaac Asimov was an American writer and professor of biochemistry at Boston University. He was known for his works of science fiction and popular science. Asimov was a prolific writer who wrote or edited more than 500 books and an estimated 90,000 letters and postcards. His books have been published in 9 of the 10 major categories of the Dewey Decimal Classification.

Asimov wrote hard science fiction. Along with Robert A. Heinlein and Arthur C. Clarke, Asimov was considered one of the "Big Three" science fiction writers during his lifetime. Asimov's most famous work is the "Foundation" series; his other major series are the "Galactic Empire" series and the Robot series. The Galactic Empire novels are set in earlier history of the same fictional universe as the Foundation series. Later, with Foundation and Earth (1986), he linked this distant future to the Robot stories, creating a unified "future history" for his stories much like those pioneered by Robert A. Heinlein and previously produced by Cordwainer Smith and Poul Anderson. He wrote hundreds of short stories, including the social science fiction novelette "Nightfall"; in 1964, it was voted the best short science fiction story of all time by the Science Fiction Writers of America. Asimov wrote the Lucky Starr series of juvenile science-fiction novels using the pen name Paul French.

Asimov also wrote mysteries and fantasy, as well as much nonfiction. Most of his popular science books explain concepts in a historical way, going as far back as possible to a time when the science in question was at its simplest stage. Examples include Guide to Science, the three-volume set Understanding Physics, and Asimov's Chronology of Science and Discovery. He wrote on numerous other scientific and non-scientific topics, such as chemistry, astronomy, mathematics, history, biblical exegesis, and literary criticism.

He was president of the American Humanist Association. The asteroid 5020 Asimov, a crater on the planet Mars, a Brooklyn elementary school, and a literary award are named in his honor.

Family name etymology

Asimov's family name derives from the first part of azimy khleb, meaning the winter grain (specifically rye) in which his great-great-great-grandfather dealt, with the Russian patronymic ending -ov added. Azimov is spelled Азимов in the Cyrillic alphabet. When the family arrived in the United States in 1923 and their name had to be spelled in Western letters, Asimov's father spelled it with an S, believing this letter to be pronounced like Z (as in German), and so it became Asimov. This later inspired one of Asimov's short stories, "Spell My Name with an S."

Asimov refused early suggestions of using a more common name as a pseudonym, and believed that its recognizability helped his career. After becoming famous, he often met readers who believed that "Isaac Asimov" was a distinctive pseudonym created by an author with a common name.

Biography

Early life

Asimov was born in Petrovichi, Smolensk Oblast, Russian SFSR on an unknown date between October 4, 1919 and January 2, 1920, inclusive. Asimov celebrated his birthday on January 2.

Asimov's parents were Anna Rachel (née Berman) and Judah Asimov, a family of Jewish millers. He was named Isaac after his mother's father, Isaac Berman. When he was born, his family lived in Petrovichi near Klimovichi, which was then Gomel Governorate in the Russian Soviet Federative Socialist Republic (now Smolensk Oblast, Russia). Asimov wrote of his father, "My father, for all his education as an Orthodox Jew, was not Orthodox in his heart", noting that "he didn't recite the myriad prayers prescribed for every action, and he never made any attempt to teach them to me".

In 1921, Asimov and 16 other children in Petrovichi developed double pneumonia. Only Asimov survived. He later had two younger siblings: a sister, Marcia (born Manya, June 17, 1922 – April 2, 2011), and a brother, Stanley (July 25, 1929 – August 16, 1995), who was vice-president of New York Newsday.

Asimov's family travelled to the United States via Liverpool on the SS Baltic, arriving on February 3, 1923 when he was three years old. Since his parents always spoke Yiddish and English with him, he never learned Russian, but he remained fluent in Yiddish as well as English. Growing up in Brooklyn, New York, Asimov taught himself to read at the age of five (and later taught his sister to read as well, enabling her to enter school in the second grade). His mother got him into first grade a year early by claiming he was born on September 7, 1919. In third grade he learned about the "error" and insisted on an official correction of the date to January 2.

After becoming established in the U.S., his parents owned a succession of candy stores in which everyone in the family was expected to work. The candy stores sold newspapers and magazines, a fact that Asimov credited as a major influence in his lifelong love of the written word, as it presented him with an unending supply of new reading material as a child that he could not have otherwise afforded. He became a naturalized U.S. citizen in 1928 at the age of eight.

Education and career

Asimov attended New York City public schools from age 5, including Boys High School in Brooklyn. Graduating at 15, he attended the City College of New York for several days before accepting a scholarship at Seth Low Junior College, a branch of Columbia University in Downtown Brooklyn designed to absorb some of the Jewish and Italian-American students who applied to Columbia College, then the institution's primary undergraduate school for men with quotas on the number of admissions from those ethnic groups. Originally a zoology major, Asimov switched to chemistry after his first semester as he disapproved of "dissecting an alley cat". After Seth Low Junior College closed in 1938, Asimov finished his Bachelor of Science degree at University Extension (later the Columbia University School of General Studies) in 1939.

After two rounds of rejections by medical schools, in 1939, Asimov applied to the graduate program in chemistry at Columbia; initially rejected and then accepted only on a probationary basis, he completed his Master of Arts degree in chemistry in 1941 and earned a Doctor of Philosophy degree in biochemistry in 1948. 

Photo
In between earning these two degrees, Asimov spent three years during World War II working as a civilian chemist at the Philadelphia Navy Yard's Naval Air Experimental Station, living in the Walnut Hill section of West Philadelphia from 1942 to 1945. In September 1945, he was drafted into the U.S. Army; if he had not had his birth date corrected while at school, he would have been officially 26 years old and ineligible. In 1946, a bureaucratic error caused his military allotment to be stopped, and he was removed from a task force days before it sailed to participate in Operation Crossroads nuclear weapons tests at Bikini Atoll. He served for almost nine months before receiving an honorable discharge on July 26, 1946. He had been promoted to corporal on July 11.

After completing his doctorate and a postdoc year, Asimov joined the faculty of the Boston University School of Medicine in 1949 with a $5,000 salary (equivalent to $52,650 in 2018), with which he remained associated thereafter. By 1952, however, he was making more money as a writer than from the university, and he eventually stopped doing research, confining his university role to lecturing students. In 1955 he was promoted to associate professor, which gave him tenure. In December 1957 Asimov was dismissed from his teaching post, with effect from 30 June 1958, because he had stopped doing research. After a struggle which lasted for two years he kept his title, and on 18 October 1979, the university honored his writing by promoting him to full professor of biochemistry. Asimov's personal papers from 1965 onward are archived at the university's Mugar Memorial Library, to which he donated them at the request of curator Howard Gotlieb.

In 1959, after a recommendation from Arthur Obermayer, Asimov's friend and a scientist on the U.S. missile protection project, Asimov was approached by DARPA to join Obermayer's team. Asimov declined on the grounds that his ability to write freely would be impaired should he receive classified information. However, he did submit a paper to DARPA titled "On Creativity" containing ideas on how government-based science projects could encourage team members to think more creatively.

Personal life

Asimov married Gertrude Blugerman (1917, Toronto, Canada – 1990, Boston, U.S.) on July 26, 1942. The couple lived in an apartment in West Philadelphia, while Asimov was employed at the Philadelphia Navy Yard (where two of his co-workers were L. Sprague de Camp and Robert A. Heinlein). They moved to Boston in May 1949, then to nearby suburbs Somerville in July 1949, Waltham in May 1951, and finally West Newton in 1956. They had two children, David (born 1951) and Robyn Joan (born 1955). In 1970, they separated, and Asimov moved back to New York, this time to the Upper West Side of Manhattan, where he lived for the rest of his life. He immediately began seeing Janet O. Jeppson and married her on November 30, 1973, two weeks after his divorce from Gertrude.

Asimov was a claustrophile: he enjoyed small, enclosed spaces. In the third volume of his autobiography, he recalls a childhood desire to own a magazine stand in a New York City Subway station, within which he could enclose himself and listen to the rumble of passing trains while reading.

Asimov was afraid of flying, doing so only twice: once in the course of his work at the Naval Air Experimental Station and once returning home from Oahu in 1946. Consequently, he seldom traveled great distances. This phobia influenced several of his fiction works, such as the Wendell Urth mystery stories and the Robot novels featuring Elijah Baley. In his later years, Asimov found enjoyment traveling on cruise ships, beginning in 1972 when he viewed the Apollo 17 launch from a cruise ship. On several cruises, he was part of the entertainment program, giving science-themed talks aboard ships such as the RMS Queen Elizabeth II.

Asimov was an able public speaker and was a frequent fixture at science fiction conventions, where he was friendly and approachable. He patiently answered tens of thousands of questions and other mail with postcards and was pleased to give autographs. He was of medium height (5 ft 9 in (1.75 m)), stocky, with – in his later years – "mutton-chop" sideburns, and a distinct New York accent. He took to wearing bolo ties after his wife Janet objected to his clip-on bow ties. His physical dexterity was very poor. He never learned to swim or ride a bicycle; however, he did learn to drive a car after he moved to Boston. In his humor book Asimov Laughs Again, he describes Boston driving as "anarchy on wheels."

Asimov's wide interests included his participation in his later years in organizations devoted to the comic operas of Gilbert and Sullivan and in The Wolfe Pack, a group of devotees of the Nero Wolfe mysteries written by Rex Stout. Many of his short stories mention or quote Gilbert and Sullivan. He was a prominent member of The Baker Street Irregulars, the leading Sherlock Holmes society, for whom he wrote an essay arguing that Professor Moriarty's work "The Dynamics of An Asteroid" involved the willful destruction of an ancient civilized planet. He was also a member of the all-male literary banqueting club the Trap Door Spiders, which served as the basis of his fictional group of mystery solvers, the Black Widowers. He later used his essay on Moriarty's work as the basis for a Black Widowers story, "The Ultimate Crime", which appeared in More Tales of the Black Widowers.

In 1984, the American Humanist Association (AHA) named him the Humanist of the Year. He was one of the signers of the Humanist Manifesto. From 1985 until his death in 1992, he served as president of the AHA, an honorary appointment. His successor was his friend and fellow writer Kurt Vonnegut. He was also a close friend of Star Trek creator Gene Roddenberry, and earned a screen credit as "special science consultant" on Star Trek: The Motion Picture for advice he gave during production.

Asimov was a founding member of the Committee for the Scientific Investigation of Claims of the Paranormal, CSICOP (now the Committee for Skeptical Inquiry) and is listed in its Pantheon of Skeptics. In a discussion with James Randi at CSICon 2016 regarding the founding of CSICOP, Kendrick Frazier said that Asimov was "a key figure in the Skeptical movement who is less well known and appreciated today, but was very much in the public eye back then." He said that Asimov being associated with CSICOP "gave it immense status and authority" in his eyes.

Asimov described Carl Sagan as one of only two people he ever met whose intellect surpassed his own. The other, he claimed, was the computer scientist and artificial intelligence expert Marvin Minsky. Asimov was a long-time member and vice president of Mensa International, albeit reluctantly; he described some members of that organization as "brain-proud and aggressive about their IQs".

Illness and death

In 1977, Asimov suffered a heart attack. In December 1983, he had triple bypass surgery, during which he contracted HIV from a blood transfusion. When his HIV status was understood, his physicians warned that if he publicized it, the anti-AIDS prejudice would likely extend to his family members. He died in New York City on April 6, 1992 and was cremated.

He was survived by his siblings, his second wife Janet Asimov, and his children from his first marriage. His brother Stanley reported the cause of death as heart and kidney failure. The family chose not to disclose that these were complications of AIDS, because within two days, on April 8, Arthur Ashe announced his own HIV infection (also contracted in 1983 from a blood transfusion during heart bypass surgery), which resulted in much public controversy; also doctors continued to insist on secrecy. Ten years later, after most of Asimov's physicians had died, Janet and Robyn Asimov agreed that the HIV story should be made public; Janet revealed it in her edition of his autobiography, It's Been a Good Life.

Writings

[T]he only thing about myself that I consider to be severe enough to warrant psychoanalytic treatment is my compulsion to write ... That means that my idea of a pleasant time is to go up to my attic, sit at my electric typewriter (as I am doing right now), and bang away, watching the words take shape like magic before my eyes.
— Asimov, 1969

Overview

Asimov's career can be divided into several periods. His early career, dominated by science fiction, began with short stories in 1939 and novels in 1950. This lasted until about 1958, all but ending after publication of The Naked Sun (1957). He began publishing nonfiction in 1952, co-authoring a college-level textbook called Biochemistry and Human Metabolism. Following the brief orbit of the first man-made satellite Sputnik I by the USSR in 1957, his production of nonfiction, particularly popular science books, greatly increased, with a consequent drop in his science fiction output. Over the next quarter century, he wrote only four science fiction novels. Starting in 1982, the second half of his science fiction career began with the publication of Foundation's Edge. From then until his death, Asimov published several more sequels and prequels to his existing novels, tying them together in a way he had not originally anticipated, making a unified series. There are, however, many inconsistencies in this unification, especially in his earlier stories.

Asimov believed his most enduring contributions would be his "Three Laws of Robotics" and the Foundation series. Furthermore, the Oxford English Dictionary credits his science fiction for introducing into the English language the words "robotics", "positronic" (an entirely fictional technology), and "psychohistory" (which is also used for a different study on historical motivations). Asimov coined the term "robotics" without suspecting that it might be an original word; at the time, he believed it was simply the natural analogue of words such as mechanics and hydraulics, but for robots. Unlike his word "psychohistory", the word "robotics" continues in mainstream technical use with Asimov's original definition. Star Trek: The Next Generation featured androids with "positronic brains" and the first-season episode "Datalore" called the positronic brain "Asimov's dream".

Science fiction

I began as a science fiction writer, and for the first eleven years of my literary career I wrote nothing but science fiction stories
— Asimov, 1972
The first installment of Asimov's Tyrann was the cover story in the fourth issue of Galaxy Science Fiction in 1951. The novel was issued in book form later that year as The Stars Like Dust.
 
The first installment of Asimov's The Caves of Steel on the cover of the October 1953 issue of Galaxy Science Fiction, illustrated by Ed Emshwiller
 
The novelette "Legal Rites", a collaboration with Frederik Pohl, the only Asimov story to appear in Weird Tales
 
Asimov became a science fiction fan in 1929, when he began reading the pulp magazines sold in his family's candy store. His father forbade reading pulps as he considered them to be trash, until Asimov persuaded him that because the science fiction magazines had "Science" in the title, they must be educational. At age 18 he joined the Futurians science fiction fan club, where he made friends who went on to become science fiction writers or editors.

Asimov began writing at the age of 11. His first published work was a humorous item on the birth of his brother for Boys High School's literary journal in 1934. In May 1937 he first thought of writing professionally, and began writing his first science fiction story, "Cosmic Corkscrew" (now lost), that year. On 17 May 1938, puzzled by a change in the schedule of Astounding Science Fiction, Asimov visited its publisher Street & Smith Publications. Inspired by the visit, he finished the story on 19 June 1938 and personally submitted it to Astounding editor John W. Campbell two days later. Campbell met with Asimov for more than an hour and promised to read the story himself. Two days later he received a rejection letter explaining why in detail. This was the first of what became almost weekly meetings with the editor while Asimov lived in New York, until moving to Boston in 1949; Campbell had a strong formative influence on Asimov and became a personal friend.

By the end of the month Asimov completed a second story, "Stowaway". Campbell rejected it on 22 July but—in "the nicest possible letter you could imagine"—encouraged him to continue writing, promising that Asimov might sell his work after another year and a dozen stories of practice. In October 1938, he sold the third story he finished, "Marooned Off Vesta", to Amazing Stories, edited by Raymond A. Palmer, and it appeared in the March 1939 issue. Asimov was paid $64 (equivalent to $1,139 in 2018), or one cent a word. Two more stories appeared that year, "The Weapon Too Dreadful to Use" in the May Amazing and "Trends" in the July Astounding, the issue fans later selected as the start of the Golden Age of Science Fiction. For 1940, ISFDB catalogs seven stories in four different pulp magazines, including one in Astounding. His earnings became enough to pay for his education, but not yet enough for him to become a full-time writer.

Asimov later said that unlike other top Golden Age writers Robert Heinlein and A. E. van Vogt—also first published in 1939, and whose talent and stardom were immediately obvious—he "(this is not false modesty) came up only gradually". Through 29 July 1940, Asimov wrote 22 stories in 25 months, of which 13 were published; he wrote in 1972 that from that date he never wrote a science fiction story (except for two "special cases") that was not published. He was famous enough that Donald Wollheim told Asimov that he purchased "The Secret Sense" for a new magazine only because of his name, and the December 1940 issue of Astonishing—featuring Asimov's name in bold—was the first magazine to base cover art on his work, but Asimov later said that neither he himself nor anyone else—except perhaps Campbell—considered him better than an often published "third rater".

Based on a conversation with Campbell, Asimov wrote his 32nd story in March and April 1941, which Astounding published in September 1941. In 1968 the Science Fiction Writers of America voted "Nightfall" the best science fiction short story ever written. In Nightfall and Other Stories Asimov wrote, "The writing of 'Nightfall' was a watershed in my professional career. ... . I was suddenly taken seriously and the world of science fiction became aware that I existed. As the years passed, in fact, it became evident that I had written a 'classic'." "Nightfall" is an archetypal example of social science fiction, a term he created to describe a new trend in the 1940s, led by authors including him and Heinlein, away from gadgets and space opera and toward speculation about the human condition.

After writing "Victory Unintentional" in January and February 1942, Asimov did not write another story for a year. Asimov expected to make chemistry his career, and was paid $2,600 annually at the Philadelphia Navy Yard, enough to marry his girlfriend; he did not expect to make much more from writing than the $1,788.50 he had earned from 28 stories sold over four years. Asimov left science fiction fandom and no longer read new magazines, and might have left the industry had not Heinlein and de Camp been coworkers and previously sold stories continued to appear. In 1942, Asimov published the first of his Foundation stories—later collected in the Foundation trilogy: Foundation (1951), Foundation and Empire (1952), and Second Foundation (1953). The books recount the fall of a vast interstellar empire and the establishment of its eventual successor. They also feature his fictional science of psychohistory, in which the future course of the history of large populations can be predicted. The trilogy and Robot series are his most famous science fiction. In 1966 they won the Hugo Award for the all-time best series of science fiction and fantasy novels. Campbell raised his rate per word, Orson Welles purchased rights to "Evidence", and anthologies reprinted his stories. By the end of the war Asimov was earning as a writer an amount equal to half of his Navy Yard salary, even after a raise, but Asimov still did not believe that writing could support him, his wife, and future children.

His "positronic" robot stories—many of which were collected in I, Robot (1950)—were begun at about the same time. They promulgated a set of rules of ethics for robots and intelligent machines that greatly influenced other writers and thinkers in their treatment of the subject. Asimov notes in his introduction to the short story collection The Complete Robot (1982) that he was largely inspired by the almost relentless tendency of robots up to that time to fall consistently into a Frankenstein plot in which they destroyed their creators. 

The robot series has led to film adaptations. With Asimov's collaboration, in about 1977, Harlan Ellison wrote a screenplay of I, Robot that Asimov hoped would lead to "the first really adult, complex, worthwhile science fiction film ever made". The screenplay has never been filmed and was eventually published in book form in 1994. The 2004 movie I, Robot, starring Will Smith, was based on an unrelated script by Jeff Vintar titled Hardwired, with Asimov's ideas incorporated later after the rights to Asimov's title were acquired. (The title was not original to Asimov but had previously been used for a story by Eando Binder.) Also, one of Asimov's robot short stories, "The Bicentennial Man", was expanded into a novel The Positronic Man by Asimov and Robert Silverberg, and this was adapted into the 1999 movie Bicentennial Man, starring Robin Williams.

Besides movies, his Foundation and Robot stories have inspired other derivative works of science fiction literature, many by well-known and established authors such as Roger MacBride Allen, Greg Bear, Gregory Benford, David Brin, and Donald Kingsbury. At least some of these appear to have been done with the blessing of, or at the request of, Asimov's widow, Janet Asimov.

In 1948, he also wrote a spoof chemistry article, "The Endochronic Properties of Resublimated Thiotimoline". At the time, Asimov was preparing his own doctoral dissertation, and for the oral examination to follow that. Fearing a prejudicial reaction from his graduate school evaluation board at Columbia University, Asimov asked his editor that it be released under a pseudonym, yet it appeared under his own name. Asimov grew concerned at the scrutiny he would receive at his oral examination, in case the examiners thought he wasn't taking science seriously. At the end of the examination, one evaluator turned to him, smiling, and said, "What can you tell us, Mr. Asimov, about the thermodynamic properties of the compound known as thiotimoline". Laughing hysterically with relief, Asimov had to be led out of the room. After a five-minute wait, he was summoned back into the room and congratulated as "Dr. Asimov".

Demand for science fiction greatly increased during the 1950s. It became possible for a genre author to write full-time. In 1949, book publisher Doubleday's science fiction editor Walter I. Bradbury accepted Asimov's unpublished "Grow Old With Me" (40,000 words), but requested that it be extended to a full novel of 70,000 words. The book appeared under the Doubleday imprint in January 1950 with the title of Pebble in the Sky. Doubleday published five more original science fiction novels by Asimov in the 1950s, along with the six juvenile Lucky Starr novels, the latter under the pseudonym of "Paul French". Doubleday also published collections of Asimov's short stories, beginning with The Martian Way and Other Stories in 1955. The early 1950s also saw Gnome Press publish one collection of Asimov's positronic robot stories as I, Robot and his Foundation stories and novelettes as the three books of the Foundation trilogy. More positronic robot stories were republished in book form as The Rest of the Robots

Books and the magazines Galaxy, and Fantasy & Science Fiction ended Asimov's dependence on Astounding. He later described the era as his "'mature' period". Asimov's "The Last Question" (1956), on the ability of humankind to cope with and potentially reverse the process of entropy, was his personal favorite story.

In 1972, his novel The Gods Themselves (which was not part of a series) was published to general acclaim, and it won the Hugo Award for Best Novel, the Nebula Award for Best Novel, and the Locus Award for Best Novel.

In December 1974, former Beatle Paul McCartney approached Asimov and asked him if he could write the screenplay for a science-fiction movie musical. McCartney had a vague idea for the plot and a small scrap of dialogue; he wished to make a film about a rock band whose members discover they are being impersonated by a group of extraterrestrials. The band and their impostors would likely be played by McCartney's group Wings, then at the height of their career. Intrigued by the idea, although he was not generally a fan of rock music, Asimov quickly produced a "treatment" or brief outline of the story. He adhered to McCartney's overall idea, producing a story he felt to be moving and dramatic. However, he did not make use of McCartney's brief scrap of dialogue, and probably as a consequence, McCartney rejected the story. The treatment now exists only in the Boston University archives.

Asimov said in 1969 that he had "the happiest of all my associations with science fiction magazines" with Fantasy & Science Fiction; "I have no complaints about Astounding, Galaxy, or any of the rest, heaven knows, but F & SF has become something special to me". Beginning in 1977, Asimov lent his name to Isaac Asimov's Science Fiction Magazine (now Asimov's Science Fiction) and penned an editorial for each issue. There was also a short-lived Asimov's SF Adventure Magazine and a companion Asimov's Science Fiction Anthology reprint series, published as magazines (in the same manner as the stablemates Ellery Queen's Mystery Magazine's and Alfred Hitchcock's Mystery Magazine's "anthologies").

Due to pressure by fans on Asimov to write another book in his Foundation series, he did so with Foundation's Edge (1982) and Foundation and Earth (1986), and then went back to before the original trilogy with Prelude to Foundation (1988) and Forward the Foundation (1992), his last novel.

Popular science

During the late 1950s and 1960s, Asimov substantially decreased his fiction output (he published only four adult novels between 1957's The Naked Sun and 1982's Foundation's Edge, two of which were mysteries). He greatly increased his nonfiction production, writing mostly on science topics; the launch of Sputnik in 1957 engendered public concern over a "science gap". Asimov explained in The Rest of the Robots that he had been unable to write substantial fiction since the summer of 1958, and observers understood him as saying that his fiction career had ended, or was permanently interrupted. Asimov recalled in 1969 that "the United States went into a kind of tizzy, and so did I. I was overcome by the ardent desire to write popular science for an America that might be in great danger through its neglect of science, and a number of publishers got an equally ardent desire to publish popular science for the same reason".

Fantasy and Science Fiction invited Asimov to continue his regular nonfiction column, begun in the now-folded bimonthly companion magazine Venture Science Fiction Magazine. The first of 399 monthly F&SF columns appeared in November 1958, until his terminal illness. These columns, periodically collected into books by Doubleday, gave Asimov a reputation as a "Great Explainer" of science; he described them as his only popular science writing in which he never had to assume complete ignorance of the subjects on the part of his readers. The column was ostensibly dedicated to popular science but Asimov had complete editorial freedom, and wrote about contemporary social issues in essays such as "Thinking About Thinking" and "Knock Plastic!".

Asimov's first wide-ranging reference work, The Intelligent Man's Guide to Science (1960), was nominated for a National Book Award, and in 1963 he won a Hugo Award – his first – for his essays for F&SF. The popularity of his science books and the income he derived from them allowed him to give up most academic responsibilities and become a full-time freelance writer. He encouraged other science fiction writers to write popular science, stating in 1967 that "the knowledgeable, skillful science writer is worth his weight in contracts", with "twice as much work as he can possibly handle".

The great variety of information covered in Asimov's writings prompted Kurt Vonnegut to ask, "How does it feel to know everything?" Asimov replied that he only knew how it felt to have the 'reputation' of omniscience: "Uneasy". Floyd C. Gale said that "Asimov has a rare talent. He can make your mental mouth water over dry facts", and "science fiction's loss has been science popularization's gain". Asimov said that "Of all the writing I do, fiction, non-fiction, adult, or juvenile, these F & SF articles are by far the most fun". He regretted, however, that he had less time for fiction—causing dissatisfied readers to send him letters of complaint—stating in 1969 that "In the last ten years, I've done a couple of novels, some collections, a dozen or so stories, but that's nothing".

Coined terms

Asimov coined the term "robotics" in his 1941 story "Liar!", though he later remarked that he believed then that he was merely using an existing word, as he stated in Gold ("The Robot Chronicles"). While acknowledging the Oxford Dictionary reference, he incorrectly states that the word was first printed about one-third of the way down the first column of page 100, Astounding Science Fiction, March 1942 printing of his short story "Runaround".

Asimov also coined the term "spome" in a paper entitled, "There's No Place Like Spome" in Atmosphere in Space Cabins and Closed Environments, originally presented as a paper to the American Chemical Society on September 13, 1965. It refers to any system closed with respect to matter and open with respect to energy capable of sustaining human life indefinitely. 

Asimov coined the term "psychohistory" in his Foundation stories to name a fictional branch of science which combines history, sociology, and mathematical statistics to make general predictions about the future behavior of very large groups of people, such as the Galactic Empire. It was first introduced in the five short stories (1942–1944) which would later be collected as the 1951 novel Foundation. Somewhat later, the term "psychohistory" was applied by others to research of the effects of psychology on history.

Other writings

In addition to his interest in science, Asimov was interested in history. Starting in the 1960s, he wrote 14 popular history books, including The Greeks: A Great Adventure (1965), The Roman Republic (1966), The Roman Empire (1967), The Egyptians (1967), The Near East: 10,000 Years of History (1968),  and Asimov's Chronology of the World (1991).

He published Asimov's Guide to the Bible in two volumes—covering the Old Testament in 1967 and the New Testament in 1969—and then combined them into one 1,300-page volume in 1981. Complete with maps and tables, the guide goes through the books of the Bible in order, explaining the history of each one and the political influences that affected it, as well as biographical information about the important characters. His interest in literature manifested itself in several annotations of literary works, including Asimov's Guide to Shakespeare (1970), Asimov's Annotated Paradise Lost (1974), and The Annotated Gulliver's Travels (1980).

Asimov was also a noted mystery author and a frequent contributor to Ellery Queen's Mystery Magazine. He began by writing science fiction mysteries such as his Wendell Urth stories, but soon moved on to writing "pure" mysteries. He published two full-length mystery novels, and wrote 66 stories about the Black Widowers, a group of men who met monthly for dinner, conversation, and a puzzle. He got the idea for the Widowers from his own association in a stag group called the Trap Door Spiders and all of the main characters (with the exception of the waiter, Henry, who he admitted resembled Wodehouse's Jeeves) were modeled after his closest friends.

Toward the end of his life, Asimov published a series of collections of limericks, mostly written by himself, starting with Lecherous Limericks, which appeared in 1975. Limericks: Too Gross, whose title displays Asimov's love of puns, contains 144 limericks by Asimov and an equal number by John Ciardi. He even created a slim volume of Sherlockian limericks. Asimov featured Yiddish humor in Azazel, The Two Centimeter Demon. The two main characters, both Jewish, talk over dinner, or lunch, or breakfast, about anecdotes of "George" and his friend Azazel. Asimov's Treasury of Humor is both a working joke book and a treatise propounding his views on humor theory. According to Asimov, the most essential element of humor is an abrupt change in point of view, one that suddenly shifts focus from the important to the trivial, or from the sublime to the ridiculous.

Particularly in his later years, Asimov to some extent cultivated an image of himself as an amiable lecher. In 1971, as a response to the popularity of sexual guidebooks such as The Sensuous Woman (by "J") and The Sensuous Man (by "M"), Asimov published The Sensuous Dirty Old Man under the byline "Dr. 'A'" (although his full name was printed on the paperback edition, first published 1972). However, by 2016, some of Asimov's behavior towards women was described as sexual harassment and cited as an example of historically problematic behavior by men in science fiction communities.

Asimov published three volumes of autobiography. In Memory Yet Green (1979) and In Joy Still Felt (1980) cover his life up to 1978. The third volume, I. Asimov: A Memoir (1994), covered his whole life (rather than following on from where the second volume left off). The epilogue was written by his widow Janet Asimov after his death. The book won a Hugo Award in 1995. Janet Asimov edited It's Been a Good Life (2002), a condensed version of his three autobiographies. He also published three volumes of retrospectives of his writing, Opus 100 (1969), Opus 200 (1979), and Opus 300 (1984).

In 1987, the Asimovs co-wrote How to Enjoy Writing: A Book of Aid and Comfort. In it they offer advice on how to maintain a positive attitude and stay productive when dealing with discouragement, distractions, rejection, and thick-headed editors. The book includes many quotations, essays, anecdotes, and husband-wife dialogues about the ups and downs of being an author.

Asimov and Star Trek creator Gene Roddenberry developed a unique relationship during Star Trek's initial launch in the late 1960s. Asimov wrote a critical essay on Star Trek's scientific accuracy for TV Guide magazine. Roddenberry retorted respectfully with a personal letter explaining the limitations of accuracy when writing a weekly series. Asimov corrected himself with a follow-up essay to TV Guide claiming that despite its inaccuracies, Star Trek was a fresh and intellectually challenging science fiction television show. The two remained friends to the point where Asimov even served as an advisor on a number of Star Trek projects.

In 1973, Asimov published a proposal for calendar reform, called the World Season Calendar. It divides the year into four seasons (named A–D) of 13 weeks (91 days) each. This allows days to be named, e.g., "D-73" instead of December 1 (due to December 1 being the 73rd day of the 4th quarter). An extra 'year day' is added for a total of 365 days.

Awards and recognition

Asimov won more than a dozen annual awards for particular works of science fiction and a half dozen lifetime awards. He also received 14 honorary doctorate degrees from universities.

Writing style

If I had the critic's mentality (which I emphatically don't) I would sit down and try to analyze my stories, work out the factors that make some more successful than others, cultivate those factors, and simply explode with excellence. But the devil with that. I won't buy success at the price of self-consciousness. I don't have the temperament for it. I'll write as I please and let the critics do the analyzing.
— Asimov, 1973

Characteristics

Asimov wrote a typed first draft composed at the keyboard. He imagined an ending first, then a beginning, then "let everything in-between work itself out as I come to it". (Asimov only used an outline once, later describing it as "like trying to play the piano from inside a straitjacket".) After correcting the draft by hand, he retyped the document as the final copy and only made one revision with minor editor-requested changes. After disliking making multiple revisions of "Black Friar of the Flame", Asimov refused to make major, second, or non-editorial revisions ("like chewing used gum"), stating that "too large a revision, or too many revisions, indicate that the piece of writing is a failure. In the time it would take to salvage such a failure, I could write a new piece altogether and have infinitely more fun in the process". He submitted "failures" to another editor.

One of the most common impressions of Asimov's fiction work is that his writing style is extremely unornamented. In 1980, science fiction scholar James Gunn, professor emeritus of English at the University of Kansas wrote of I, Robot:
Except for two stories—"Liar!" and "Evidence"—they are not stories in which character plays a significant part. Virtually all plot develops in conversation with little if any action. Nor is there a great deal of local color or description of any kind. The dialogue is, at best, functional and the style is, at best, transparent. ... . The robot stories and, as a matter of fact, almost all Asimov fiction—play themselves on a relatively bare stage.
Asimov addressed such criticism at the beginning of Nemesis:
I made up my mind long ago to follow one cardinal rule in all my writing—to be 'clear'. I have given up all thought of writing poetically or symbolically or experimentally, or in any of the other modes that might (if I were good enough) get me a Pulitzer prize. I would write merely clearly and in this way establish a warm relationship between myself and my readers, and the professional critics—Well, they can do whatever they wish.
Gunn cited examples of a more complex style, such as the climax of "Liar!". Sharply drawn characters occur at key junctures of his storylines: Susan Calvin in "Liar!" and "Evidence", Arkady Darell in Second Foundation, Elijah Baley in The Caves of Steel, and Hari Seldon in the Foundation prequels. 

Other than books by Gunn and Patrouch, a relative dearth of "literary" criticism exists on Asimov (particularly when compared to the sheer volume of his output). Cowart and Wymer's Dictionary of Literary Biography (1981) gives a possible reason:
His words do not easily lend themselves to traditional literary criticism because he has the habit of centering his fiction on plot and clearly stating to his reader, in rather direct terms, what is happening in his stories and why it is happening. In fact, most of the dialogue in an Asimov story, and particularly in the Foundation trilogy, is devoted to such exposition. Stories that clearly state what they mean in unambiguous language are the most difficult for a scholar to deal with because there is little to be interpreted.
Gunn's and Patrouch's respective studies of Asimov both state that a clear, direct prose style is still a style. Gunn's 1982 book comments in detail on each of Asimov's novels. He does not praise all of Asimov's fiction (nor does Patrouch), but calls some passages in The Caves of Steel "reminiscent of Proust". When discussing how that novel depicts night falling over futuristic New York City, Gunn says that Asimov's prose "need not be ashamed anywhere in literary society".

Although he prided himself on his unornamented prose style (for which he credited Clifford D. Simak as an early influence), and said in 1973 that his style had not changed, Asimov also enjoyed giving his longer stories complicated narrative structures, often by arranging chapters in nonchronological ways. Some readers have been put off by this, complaining that the nonlinearity is not worth the trouble and adversely affects the clarity of the story. For example, the first third of The Gods Themselves begins with Chapter 6, then backtracks to fill in earlier material. (John Campbell advised Asimov to begin his stories as late in the plot as possible. This advice helped Asimov create "Reason", one of the early Robot stories. See In Memory Yet Green for details of that time period.) Patrouch found that the interwoven and nested flashbacks of The Currents of Space did serious harm to that novel, to such an extent that only a "dyed-in-the-kyrt Asimov fan" could enjoy it. Asimov's tendency to contort his timelines is perhaps most apparent in his later novel Nemesis, in which one group of characters lives in the "present" and another group starts in the "past", beginning 15 years earlier and gradually moving toward the time period of the first group.

Limitations

Sexuality

Asimov attributed the lack of romance and sex in his fiction to the "early imprinting" from starting his writing career when he had never been on a date and "didn't know anything about girls". He was sometimes criticized for the general absence of sex (and of extraterrestrial life) in his science fiction. He claimed he wrote The Gods Themselves to respond to these criticisms, which often came from New Wave science fiction (and often British) writers. The second part (of three) of the novel is set on an alien world with three sexes, and the sexual behavior of these creatures is extensively depicted.

Alien life

Asimov once explained that his reluctance to write about aliens came from an incident early in his career when Astounding's editor John Campbell rejected one of his science fiction stories because the alien characters were portrayed as superior to the humans. The nature of the rejection led him to believe that Campbell may have based his bias towards humans in stories on a real-world racial bias. Unwilling to write only weak alien races, and concerned that a confrontation would jeopardize his and Campbell's friendship, he decided he would not write about aliens at all. Nevertheless, in response to these criticisms, he wrote The Gods Themselves, which contains aliens and alien sex. The book won the Nebula Award for Best Novel in 1972, and the Hugo Award for Best Novel in 1973. Asimov said that of all his writings, he was most proud of the middle section of The Gods Themselves, the part that deals with those themes.

In the Hugo Award-winning novella "Gold", Asimov describes an author, clearly based on himself, who has one of his books (The Gods Themselves) adapted into a "compu-drama", essentially photo-realistic computer animation. The director criticizes the fictionalized Asimov ("Gregory Laborian") for having an extremely non-visual style, making it difficult to adapt his work, and the author explains that he relies on ideas and dialogue rather than description to get his points across.

Portrayal of women

Asimov was criticized for a lack of strong female characters in his early work. In his autobiographical writings, such as Gold ("Women and Science Fiction"), he acknowledges this and responds by pointing to inexperience. His later novels, written with more female characters but in essentially the same prose style as his early science-fiction stories, brought this matter to a wider audience. For example, the August 25, 1985 Washington Post's "Book World" section reports of Robots and Empire as follows:
In 1940, Asimov's humans were stripped-down masculine portraits of Americans from 1940, and they still are. His robots were tin cans with speedlines like an old Studebaker, and still are; the Robot tales depended on an increasingly unworkable distinction between movable and unmovable artificial intelligences, and still do. In the Asimov universe, because it was conceived a long time ago, and because its author abhors confusion, there are no computers whose impact is worth noting, no social complexities, no genetic engineering, aliens, arcologies, multiverses, clones, sin or sex; his heroes (in this case R. Daneel Olivaw, whom we first met as the robot protagonist of The Caves of Steel and its sequels), feel no pressure of information, raw or cooked, as the simplest of us do today; they suffer no deformation from the winds of the Asimov future, because it is so deeply and strikingly orderly.
However, some of his robot stories, including the earliest ones, featured the character Susan Calvin, a forceful and intelligent woman who regularly out-performed her male colleagues.

Views

There is a perennial question among readers as to whether the views contained in a story reflect the views of the author. The answer is, "Not necessarily—" And yet one ought to add another short phrase "—but usually."
— Asimov, 1969

Religion

Isaac Asimov was an atheist, a humanist, and a rationalist. He did not oppose religious conviction in others, but he frequently railed against superstitious and pseudoscientific beliefs that tried to pass themselves off as genuine science. During his childhood, his father and mother observed Orthodox Jewish traditions, though not as stringently as they had in Petrovichi; they did not, however, force their beliefs upon young Isaac. Thus, he grew up without strong religious influences, coming to believe that the Torah represented Hebrew mythology in the same way that the Iliad recorded Greek mythology. When he was 13, he chose not to have a bar mitzvah. As his books Treasury of Humor and Asimov Laughs Again record, Asimov was willing to tell jokes involving God, Satan, the Garden of Eden, Jerusalem, and other religious topics, expressing the viewpoint that a good joke can do more to provoke thought than hours of philosophical discussion.

For a brief while, his father worked in the local synagogue to enjoy the familiar surroundings and, as Isaac put it, "shine as a learned scholar" versed in the sacred writings. This scholarship was a seed for his later authorship and publication of Asimov's Guide to the Bible, an analysis of the historic foundations for both the Old and New Testaments. For many years, Asimov called himself an atheist; however, he considered the term somewhat inadequate, as it described what he did not believe rather than what he did. Eventually, he described himself as a "humanist" and considered that term more practical. He did, however, continue to identify himself as a nonobservant Jew, as stated in his introduction to Jack Dann's anthology of Jewish science fiction, Wandering Stars: "I attend no services and follow no ritual and have never undergone that curious puberty rite, the bar mitzvah. It doesn't matter. I am Jewish."

When asked in an interview in 1982 if he was an atheist, Asimov replied,
I am an atheist, out and out. It took me a long time to say it. I've been an atheist for years and years, but somehow I felt it was intellectually unrespectable to say one was an atheist, because it assumed knowledge that one didn't have. Somehow it was better to say one was a humanist or an agnostic. I finally decided that I'm a creature of emotion as well as of reason. Emotionally I am an atheist. I don't have the evidence to prove that God doesn't exist, but I so strongly suspect he doesn't that I don't want to waste my time.
Likewise he said about religious education: "I would not be satisfied to have my kids choose to be religious without trying to argue them out of it, just as I would not be satisfied to have them decide to smoke regularly or engage in any other practice I consider detrimental to mind or body."

In his last volume of autobiography, Asimov wrote,
If I were not an atheist, I would believe in a God who would choose to save people on the basis of the totality of their lives and not the pattern of their words. I think he would prefer an honest and righteous atheist to a TV preacher whose every word is God, God, God, and whose every deed is foul, foul, foul.
The same memoir states his belief that Hell is "the drooling dream of a sadist" crudely affixed to an all-merciful God; if even human governments were willing to curtail cruel and unusual punishments, wondered Asimov, why would punishment in the afterlife not be restricted to a limited term? Asimov rejected the idea that a human belief or action could merit infinite punishment. If an afterlife existed, he claimed, the longest and most severe punishment would be reserved for those who "slandered God by inventing Hell".

Asimov said about using religious motifs in his writing:
I tend to ignore religion in my own stories altogether, except when I absolutely have to have it. ... and, whenever I bring in a religious motif, that religion is bound to seem vaguely Christian because that is the only religion I know anything about, even though it is not mine. An unsympathetic reader might think that I am "burlesquing" Christianity, but I am not. Then too, it is impossible to write science fiction and really ignore religion.

Politics

Asimov became a staunch supporter of the Democratic Party during the New Deal, and thereafter remained a political liberal. He was a vocal opponent of the Vietnam War in the 1960s and in a television interview during the early 1970s he publicly endorsed George McGovern. He was unhappy about what he considered an "irrationalist" viewpoint taken by many radical political activists from the late 1960s and onwards. In his second volume of autobiography, In Joy Still Felt, Asimov recalled meeting the counterculture figure Abbie Hoffman. Asimov's impression was that the 1960s' counterculture heroes had ridden an emotional wave which, in the end, left them stranded in a "no-man's land of the spirit" from which he wondered if they would ever return.

Asimov vehemently opposed Richard Nixon, considering him "a crook and a liar". He closely followed Watergate, and was pleased when the president was forced to resign. Asimov was dismayed over the pardon extended to Nixon by his successor: "I was not impressed by the argument that it has spared the nation an ordeal. To my way of thinking, the ordeal was necessary to make certain it would never happen again."

After Asimov's name appeared in the mid-1960s on a list of people the Communist Party USA "considered amenable" to its goals, the FBI investigated him. Because of his academic background, the bureau briefly considered Asimov as a possible candidate for known Soviet spy ROBPROF, but found nothing suspicious in his life or background.

Though from a Jewish family, Asimov appeared to hold an equivocal attitude towards Israel. In his first autobiography, he indicates his support for the safety of Israel, though insisting that he was not a Zionist. In his third autobiography, Asimov stated his opposition to the creation of a Jewish state, on the grounds that he was opposed to the concept of nation-states in general, and supported the notion of a single humanity. Asimov especially worried about the safety of Israel given that it had been created among hostile neighbors, and said that Jews had merely created for themselves another "Jewish ghetto".

Social issues

Asimov believed that "science fiction ... serve[s] the good of humanity". He considered himself a feminist even before women's liberation became a widespread movement; he argued that the issue of women's rights was closely connected to that of population control. Furthermore, he believed that homosexuality must be considered a "moral right" on population grounds, as must all consenting adult sexual activity that does not lead to reproduction. He issued many appeals for population control, reflecting a perspective articulated by people from Thomas Malthus through Paul R. Ehrlich.

In a 1988 interview by Bill Moyers, Asimov proposed computer-aided learning, where people would use computers to find information on subjects in which they were interested. He thought this would make learning more interesting, since people would have the freedom to choose what to learn, and would help spread knowledge around the world. Also, the one-to-one model would let students learn at their own pace. Asimov thought that people would live in space by the year 2019.

Environment and population

Asimov's defense of civil applications of nuclear power even after the Three Mile Island nuclear power plant incident damaged his relations with some of his fellow liberals. In a letter reprinted in Yours, Isaac Asimov, he states that although he would prefer living in "no danger whatsoever" than near a nuclear reactor, he would still prefer a home near a nuclear power plant than in a slum on Love Canal or near "a Union Carbide plant producing methyl isocyanate", the latter being a reference to the Bhopal disaster.

In the closing years of his life, Asimov blamed the deterioration of the quality of life that he perceived in New York City on the shrinking tax base caused by the middle-class flight to the suburbs, though he continued to support high taxes on the middle class to pay for social programs. His last nonfiction book, Our Angry Earth (1991, co-written with his long-time friend, science fiction author Frederik Pohl), deals with elements of the environmental crisis such as overpopulation, oil dependence, war, global warming, and the destruction of the ozone layer. In response to being presented by Bill Moyers with the question "What do you see happening to the idea of dignity to human species if this population growth continues at its present rate?", Asimov responded:
It's going to destroy it all ... if you have 20 people in the apartment and two bathrooms, no matter how much every person believes in freedom of the bathroom, there is no such thing. You have to set up, you have to set up times for each person, you have to bang at the door, aren't you through yet, and so on. And in the same way, democracy cannot survive overpopulation. Human dignity cannot survive it. Convenience and decency cannot survive it. As you put more and more people onto the world, the value of life not only declines, but it disappears.

Other authors

Asimov enjoyed the writings of J. R. R. Tolkien, using The Lord of the Rings as a plot point in a Black Widowers story. (Tolkien said that he enjoyed Asimov's science fiction.) He acknowledged other writers as superior to himself in talent, saying of Harlan Ellison, "He is (in my opinion) one of the best writers in the world, far more skilled at the art than I am." Asimov disapproved of the New Wave's growing influence, however, stating in 1967 "I want science fiction. I think science fiction isn't really science fiction if it lacks science. And I think the better and truer the science, the better and truer the science fiction". The feelings of friendship and respect between Asimov and Arthur C. Clarke were demonstrated by the so-called "Clarke-Asimov Treaty of Park Avenue", negotiated as they shared a cab in New York. This stated that Asimov was required to insist that Clarke was the best science fiction writer in the world (reserving second-best for himself), while Clarke was required to insist that Asimov was the best science writer in the world (reserving second-best for himself). Thus, the dedication in Clarke's book Report on Planet Three (1972) reads: "In accordance with the terms of the Clarke-Asimov treaty, the second-best science writer dedicates this book to the second-best science-fiction writer." 

Asimov became a fan of mystery stories at the same time as science fiction. He preferred to read the former to latter because "I read every [science fiction] story keenly aware that it might be worse than mine, in which case I had no patience with it, or that it might be better, in which case I felt miserable". Asimov wrote "I make no secret of the fact that in my mysteries I use Agatha Christie as my model. In my opinion, her mysteries are the best ever written, far better than the Sherlock Holmes stories, and Hercule Poirot is the best detective fiction has seen. Why should I not use as my model what I consider the best?" He enjoyed Sherlock Holmes, but considered Arthur Conan Doyle to be "a slapdash and sloppy writer."

Asimov also enjoyed humorous stories, particularly those of P. G. Wodehouse.

Influence

Paul Krugman, holder of a Nobel Prize in Economics, has stated Asimov's concept of psychohistory inspired him to become an economist.

John Jenkins, who has reviewed the vast majority of Asimov's written output, once observed, "It has been pointed out that most science fiction writers since the 1950s have been affected by Asimov, either modeling their style on his or deliberately avoiding anything like his style." Along with such figures as Bertrand Russell and Karl Popper, Asimov left his mark as one of the most distinguished interdisciplinarians of the 20th century. "Few individuals", writes James L. Christian, "understood better than Isaac Asimov what synoptic thinking is all about. His almost 500 books—which he wrote as a specialist, a knowledgeable authority, or just an excited layman—range over almost all conceivable subjects: the sciences, history, literature, religion, and of course, science fiction." Asimov explained his quest for holistic knowledge:
Through a series of developments of absorbing lack of interest (as far as these pages are concerned), I found myself doing research on a biochemical topic. In that area of study I obtained my Ph.D., and in no time at all I was teaching biochemistry at a medical school.
But even that was too wide a subject. From books to nonfiction, to science, to chemistry, to biochemistry—and not yet enough. The orchard had to be narrowed down further. To do research, I had to find myself a niche within biochemistry, so I began work on nucleic acids ...
And at about that point, I rebelled! I could not stand the claustrophobia that clamped down upon me. I looked with horror, backward and forward across the years, at a horizon that was narrowing down and narrowing down to so petty a portion of the orchard. What I wanted was all the orchard, or as much of it as I could cover in a lifetime of running ...
I have never been sorry for my stubborn advance toward generalization. To be sure, I can't wander in detail through all the orchard, any more than anyone else can, no matter how stupidly determined I may be to do so. Life is far too short and the mind is far too limited. But I can float over the orchard as in a balloon.

Television, music, and film appearances

Selected bibliography

Depending on the counting convention used, and including all titles, charts, and edited collections, there may be currently over 500 books in Asimov's bibliography— as well as his individual short stories, individual essays, and criticism. For his 100th, 200th, and 300th books (based on his personal count), Asimov published Opus 100 (1969), Opus 200 (1979), and Opus 300 (1984), celebrating his writing.

Asimov was so prolific that his books span all major categories of the Dewey Decimal Classification except for category 100, philosophy and psychology. Although Asimov did write several essays about psychology, and forewords for the books The Humanist Way (1988) and In Pursuit of Truth (1982), which were classified in the 100s category, none of his own books was classified in that category.

According to UNESCO's Index Translationum database, Asimov is the world's 24th most-translated author.

An online exhibit in West Virginia University Libraries' virtually complete Asimov Collection displays features, visuals, and descriptions of some of his over 600 books, games, audio recordings, videos, and wall charts. Many first, rare, and autographed editions are in the Libraries' Rare Book Room. Book jackets and autographs are presented online along with descriptions and images of children's books, science fiction art, multimedia, and other materials in the collection.

For a listing of Asimov's science fiction books in chronological order within his future history, see the Foundation series list of books.

Science fiction

"Greater Foundation" series

The Robot series was originally separate from the Foundation series. The Galactic Empire novels were published as independent stories, set earlier in the same future as Foundation. Later in life, Asimov synthesized the Robot series into a single coherent "history" that appeared in the extension of the Foundation series.

Human–robot interaction

From Wikipedia, the free encyclopedia

Human–robot interaction is the study of interactions between humans and robots. It is often referred as HRI by researchers. Human–robot interaction is a multidisciplinary field with contributions from human–computer interaction, artificial intelligence, robotics, natural language understanding, design, and social sciences.

Origins

Human–robot interaction has been a topic of both science fiction and academic speculation even before any robots existed. Because HRI depends on a knowledge of (sometimes natural) human communication, many aspects of HRI are continuations of human communications topics that are much older than robotics per se.

The origin of HRI as a discrete problem was stated by 20th-century author Isaac Asimov in 1941, in his novel I, Robot. He states the Three Laws of Robotics as, 

  1. A robot may not injure a human being or, through inaction, allow a human being to come to harm.
  2. A robot must obey any orders given to it by human beings, except where such orders would conflict with the First Law.
  3. A robot must protect its own existence as long as such protection does not conflict with the First or Second Law.

These three laws of robotics determine the idea of safe interaction. The closer the human and the robot get and the more intricate the relationship becomes, the more the risk of a human being injured rises. Nowadays in advanced societies, manufacturers employing robots solve this issue by not letting humans and robots share the workspace at any time. This is achieved by defining safe zones using lidar sensors or physical cages. Thus the presence of humans is completely forbidden in the robot workspace while it is working. 

With the advances of artificial intelligence, the autonomous robots could eventually have more proactive behaviors, planning their motion in complex unknown environments. These new capabilities keep safety as the primary issue and efficiency as secondary. To allow this new generation of robot, research is being conducted on human detection, motion planning, scene reconstruction, intelligent behavior through task planning and compliant behavior using force control (impedance or admittance control schemes).

The goal of HRI research is to define models of humans' expectations regarding robot interaction to guide robot design and algorithmic development that would allow more natural and effective interaction between humans and robots. Research ranges from how humans work with remote, tele-operated unmanned vehicles to peer-to-peer collaboration with anthropomorphic robots.

Many in the field of HRI study how humans collaborate and interact and use those studies to motivate how robots should interact with humans.

The goal of friendly human–robot interactions

Kismet can produce a range of facial expressions.
 
Robots are artificial agents with capacities of perception and action in the physical world often referred by researchers as workspace. Their use has been generalized in factories but nowadays they tend to be found in the most technologically advanced societies in such critical domains as search and rescue, military battle, mine and bomb detection, scientific exploration, law enforcement, entertainment and hospital care.

These new domains of applications imply a closer interaction with the user. The concept of closeness is to be taken in its full meaning, robots and humans share the workspace but also share goals in terms of task achievement. This close interaction needs new theoretical models, on one hand for the robotics scientists who work to improve the robots utility and on the other hand to evaluate the risks and benefits of this new "friend" for our modern society.

With the advance in AI, the research is focusing on one part towards the safest physical interaction but also on a socially correct interaction, dependent on cultural criteria. The goal is to build an intuitive, and easy communication with the robot through speech, gestures, and facial expressions.

Dautenhahn refers to friendly Human–robot interaction as "Robotiquette" defining it as the "social rules for robot behavior (a ‘robotiquette’) that is comfortable and acceptable to humans" The robot has to adapt itself to our way of expressing desires and orders and not the contrary. But every day environments such as homes have much more complex social rules than those implied by factories or even military environments. Thus, the robot needs perceiving and understanding capacities to build dynamic models of its surroundings. It needs to categorize objects, recognize and locate humans and further their emotions. The need for dynamic capacities pushes forward every sub-field of robotics.

Furthermore, by understanding and perceiving social cues, robots can enable collaborative scenarios with humans. For example, with the rapid rise of personal fabrication machines such as desktop 3d printers, laser cutters, etc., entering our homes, scenarios may arise where robots can collaboratively share control, co-ordinate and achieve tasks together. Industrial robots have already been integrated into industrial assembly lines and are collaboratively working with humans. The social impact of such robots have been studied and has indicated that workers still treat robots and social entities, rely on social cues to understand and work together.

On the other end of HRI research the cognitive modelling of the "relationship" between human and the robots benefits the psychologists and robotic researchers the user study are often of interests on both sides. This research endeavours part of human society. For effective human – humanoid robot interaction numerous communication skills and related features should be implemented in the design of such artificial agents/systems.

General HRI research

HRI research spans a wide range of field, some general to the nature of HRI.

Methods for perceiving humans

Most methods intend to build a 3D model through vision of the environment. The proprioception sensors permit the robot to have information over its own state. This information is relative to a reference. 

Methods for perceiving humans in the environment are based on sensor information. Research on sensing components and software led by Microsoft provide useful results for extracting the human kinematics . An example of older technique is to use color information for example the fact that for light skinned people the hands are lighter than the clothes worn. In any case a human modeled a priori can then be fitted to the sensor data. The robot builds or has (depending on the level of autonomy the robot has) a 3D mapping of its surroundings to which is assigned the humans locations.
A speech recognition system is used to interpret human desires or commands. By combining the information inferred by proprioception, sensor and speech the human position and state (standing, seated).

Methods for motion planning

Motion planning in dynamic environment is a challenge that is for the moment only achieved for 3 to 10 degrees of freedom robots. Humanoid robots or even 2 armed robots that can have up to 40 degrees of freedom are unsuited for dynamic environments with today's technology. However lower-dimensional robots can use potential field method to compute trajectories avoiding collisions with human.

Cognitive models and theory of mind

Humans exhibit negative social and emotional responses as well as decreased trust toward some robots that closely, but imperfectly, resemble humans; this phenomenon has been termed the "Uncanny Valley." However recent research in telepresence robots has established that mimicking human body postures and expressive gestures has made the robots likeable and engaging in a remote setting. Further, the presence of a human operator was felt more strongly when tested with an android or humanoid telepresence robot than with normal video communication through a monitor.

While there is a growing body of research about users perceptions and emotions towards robots, we are still far from a complete understanding. Only additional experiments will determine a more precise model. 

Based on past research we have some indications about current user sentiment and behavior around robots:
  • During initial interactions, people are more uncertain, anticipate less social presence, and have fewer positive feelings when thinking about interacting with robots. This finding has been called the human-to-human interaction script.
  • It has been observed that when the robot performs a proactive behavior and does not respect a "safety distance" (by penetrating the user space) the user sometimes expresses fear. This fear response is person-dependent.
  • It has also been shown that when a robot has no particular use, negative feelings are often expressed. The robot is perceived as useless and its presence becomes annoying.
  • People have also been shown to attribute personality characteristics to the robot that were not implemented in software.

Methods for human-robot coordination

A large body of work in the field of human-robot interaction has looked at how humans and robots may better collaborate. The primary social cue for humans while collaborating is the shared perception of an activity, to this end researchers have investigated anticipatory robot control through various methods including: monitoring the behaviors of human partners using eye tracking, making inferences about human task intent, and proactive action on the part of the robot. The studies revealed that the anticipatory control helped users perform tasks faster than with reactive control alone. 

A common approach to program social cues into robots is to first study human-human behaviors and then transfer the learning. For example, coordination mechanisms in human-robot collaboration are based on work in neuroscience which examined how to enable joint action in human-human configuration by studying perception and action in a social context rather than in isolation. These studies have revealed that maintaining a shared representation of the task is crucial for accomplishing tasks in groups. For example, the authors have examined the task of driving together by separating responsibilities of acceleration and braking i.e., one person is responsible for accelerating and the other for braking; the study revealed that pairs reached the same level of performance as individuals only when they received feedback about the timing of each other's actions. Similarly, researchers have studied the aspect of human-human handovers with household scenarios like passing dining plates in order to enable an adaptive control of the same in human-robot handovers. Most recently, researchers have studied a system that automatically distributes assembly tasks among co-located workers to improve co-ordination.

Application-oriented HRI research

In addition to general HRI research, researchers are currently exploring application areas for human-robot interaction systems. Application-oriented research is used to help bring current robotics technologies to bear against problems that exist in today's society. While human-robot interaction is still a rather young area of interest, there is active development and research in many areas.

HRI/OS research

The Human-Robot Interaction Operating System(HRI/OS), "provides a structured software framework for building human-robot teams, supports a variety of user interfaces, enables humans and robots to engage in task-oriented dialogue, and facilitates integration of robots through an extensible API".

Search and rescue

First responders face great risks in search and rescue (SAR) settings, which typically involve environments that are unsafe for a human to travel. In addition, technology offers tools for observation that can greatly speed-up and improve the accuracy of human perception. Robots can be used to address these concerns . Research in this area includes efforts to address robot sensing, mobility, navigation, planning, integration, and tele-operated control
.
SAR robots have already been deployed to environments such as the Collapse of the World Trade Center.

Other application areas include:
  • Entertainment
  • Education
  • Field robotics
  • Home and companion robotics
  • Hospitality
  • Rehabilitation and Elder Care
  • Robot Assisted Therapy (RAT)

Properties

Bartneck and Okada suggest that a robotic user interface can be described by the following four properties:
Tool – toy scale
  • Is the system designed to solve a problem effectively or is it just for entertainment?
Remote control – autonomous scale
  • Does the robot require remote control or is it capable of action without direct human influence?
Reactive – dialogue scale
  • Does the robot rely on a fixed interaction pattern or is it able to have dialogue — exchange of information — with a human?
Anthropomorphism scale
  • Does it have the shape or properties of a human?

Conferences

International Conference on Social Robotics

The International Conference on Social Robotics is a conference for scientists, researchers, and practitioners to report and discuss the latest progress of their forefront research and findings in social robotics, as well as interactions with human beings and integration into our society.
  • ICSR2009, Incheon, Korea in collaboration with the FIRA RoboWorld Congress
  • ICSR2010, Singapore
  • ICSR2011, Amsterdam, Netherlands

International Conference on Human-Robot Personal Relationships

International Symposium on New Frontiers in Human-Robot Interaction

This symposium is organized in collaboration with the Annual Convention of the Society for the Study of Artificial Intelligence and Simulation of Behaviour.
  • 2015, Canterbury, United Kingdom
  • 2014, London, United Kingdom
  • 2010, Leicester, United Kingdom
  • 2009, Edinburgh, United Kingdom

IEEE International Symposium in Robot and Human Interactive Communication

The IEEE International Symposium on Robot and Human Interactive Communication ( RO-MAN ) was founded in 1992 by Profs. Toshio Fukuda, Hisato Kobayashi, Hiroshi Harashima and Fumio Hara. Early workshop participants were mostly Japanese, and the first seven workshops were held in Japan. Since 1999, workshops have been held in Europe and the United States as well as Japan, and participation has been of international scope.

ACM/IEEE International Conference on Human-Robot Interaction

This conference is amongst the best conferences in the field of HRI and has a very selective reviewing process. The average acceptance rate is 26% and the average attendance is 187. Around 65% of the contributions to the conference come from the US and the high level of quality of the submissions to the conference becomes visible by the average of 10 citations that the HRI papers attracted so far.
  • HRI 2006 in Salt Lake City, Utah, USA, Acceptance Rate: 0.29
  • HRI 2007 in Washington, D.C., USA, Acceptance Rate: 0.23
  • HRI 2008 in Amsterdam, Netherlands, Acceptance Rate: 0.36 (0.18 for oral presentations)
  • HRI 2009 in San Diego, CA, USA, Acceptance Rate: 0.19
  • HRI 2010 in Osaka, Japan, Acceptance Rate: 0.21
  • HRI 2011 in Lausanne, Switzerland, Acceptance Rate: 0.22 for full papers
  • HRI 2012 in Boston, Massachusetts, USA, Acceptance Rate: 0.25 for full papers
  • HRI 2013 in Tokyo, Japan, Acceptance Rate: 0.24 for full papers
  • HRI 2014 in Bielefeld, Germany, Acceptance Rate: 0.24 for full papers
  • HRI 2015 in Portland, Oregon, USA, Acceptance Rate: 0.25 for full papers
  • HRI 2016 in Christchurch, New Zealand, Acceptance Rate: 0.25 for full papers
  • HRI 2017 in Vienna, Austria, Acceptance Rate: 0.24 for full papers
  • HRI 2018 in Chicago, USA, Acceptance Rate: 0.24 for full papers

International Conference on Human-Agent Interaction

Related conferences

There are many conferences that are not exclusively HRI, but deal with broad aspects of HRI, and often have HRI papers presented.
  • IEEE-RAS/RSJ International Conference on Humanoid Robots (Humanoids)
  • Ubiquitous Computing (UbiComp)
  • IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS)
  • Intelligent User Interfaces (IUI)
  • Computer Human Interaction (CHI)
  • American Association for Artificial Intelligence (AAAI)
  • INTERACT

Related journals

There are currently two dedicated HRI Journals
  • International Journal of Social Robotics
  • The open access Journal of Human-Robot Interaction
and there are several more general journals in which one will find HRI articles.

Nanomedicine (updated)

From Wikipedia, the free encyclopedia

Nanomedicine is the medical application of nanotechnology. Nanomedicine ranges from the medical applications of nanomaterials and biological devices, to nanoelectronic biosensors, and even possible future applications of molecular nanotechnology such as biological machines. Current problems for nanomedicine involve understanding the issues related to toxicity and environmental impact of nanoscale materials (materials whose structure is on the scale of nanometers, i.e. billionths of a meter).

Functionalities can be added to nanomaterials by interfacing them with biological molecules or structures. The size of nanomaterials is similar to that of most biological molecules and structures; therefore, nanomaterials can be useful for both in vivo and in vitro biomedical research and applications. Thus far, the integration of nanomaterials with biology has led to the development of diagnostic devices, contrast agents, analytical tools, physical therapy applications, and drug delivery vehicles. 

Nanomedicine seeks to deliver a valuable set of research tools and clinically useful devices in the near future. The National Nanotechnology Initiative expects new commercial applications in the pharmaceutical industry that may include advanced drug delivery systems, new therapies, and in vivo imaging. Nanomedicine research is receiving funding from the US National Institutes of Health Common Fund program, supporting four nanomedicine development centers.

Nanomedicine sales reached $16 billion in 2015, with a minimum of $3.8 billion in nanotechnology R&D being invested every year. Global funding for emerging nanotechnology increased by 45% per year in recent years, with product sales exceeding $1 trillion in 2013. As the nanomedicine industry continues to grow, it is expected to have a significant impact on the economy.

Drug delivery

Nanoparticles (top), liposomes (middle), and dendrimers (bottom) are some nanomaterials being investigated for use in nanomedicine.
 
Nanotechnology has provided the possibility of delivering drugs to specific cells using nanoparticles. The overall drug consumption and side-effects may be lowered significantly by depositing the active agent in the morbid region only and in no higher dose than needed. Targeted drug delivery is intended to reduce the side effects of drugs with concomitant decreases in consumption and treatment expenses. Drug delivery focuses on maximizing bioavailability both at specific places in the body and over a period of time. This can potentially be achieved by molecular targeting by nanoengineered devices. A benefit of using nanoscale for medical technologies is that smaller devices are less invasive and can possibly be implanted inside the body, plus biochemical reaction times are much shorter. These devices are faster and more sensitive than typical drug delivery. The efficacy of drug delivery through nanomedicine is largely based upon: a) efficient encapsulation of the drugs, b) successful delivery of drug to the targeted region of the body, and c) successful release of the drug.

Drug delivery systems, lipid- or polymer-based nanoparticles, can be designed to improve the pharmacokinetics and biodistribution of the drug. However, the pharmacokinetics and pharmacodynamics of nanomedicine is highly variable among different patients. When designed to avoid the body's defense mechanisms, nanoparticles have beneficial properties that can be used to improve drug delivery. Complex drug delivery mechanisms are being developed, including the ability to get drugs through cell membranes and into cell cytoplasm. Triggered response is one way for drug molecules to be used more efficiently. Drugs are placed in the body and only activate on encountering a particular signal. For example, a drug with poor solubility will be replaced by a drug delivery system where both hydrophilic and hydrophobic environments exist, improving the solubility. Drug delivery systems may also be able to prevent tissue damage through regulated drug release; reduce drug clearance rates; or lower the volume of distribution and reduce the effect on non-target tissue. However, the biodistribution of these nanoparticles is still imperfect due to the complex host's reactions to nano- and microsized materials and the difficulty in targeting specific organs in the body. Nevertheless, a lot of work is still ongoing to optimize and better understand the potential and limitations of nanoparticulate systems. While advancement of research proves that targeting and distribution can be augmented by nanoparticles, the dangers of nanotoxicity become an important next step in further understanding of their medical uses.

Nanoparticles are under research for their potential to decrease antibiotic resistance or for various antimicrobial uses. Nanoparticles might also be used to circumvent multidrug resistance (MDR) mechanisms.

Systems under research

Advances in lipid nanotechnology were instrumental in engineering medical nanodevices and novel drug delivery systems, as well as in developing sensing applications. Another system for microRNA delivery under preliminary research is nanoparticles formed by the self-assembly of two different microRNAs deregulated in cancer. One potential application is based on small electromechanical systems, such as nanoelectromechanical systems being investigated for the active release of drugs and sensors for possible cancer treatment with iron nanoparticles or gold shells.

Applications

Some nanotechnology-based drugs that are commercially available or in human clinical trials include:
  • Abraxane, approved by the U.S. Food and Drug Administration (FDA) to treat breast cancer, non-small- cell lung cancer (NSCLC) and pancreatic cancer, is the nanoparticle albumin bound paclitaxel.
  • Doxil was originally approved by the FDA for the use on HIV-related Kaposi's sarcoma. It is now being used to also treat ovarian cancer and multiple myeloma. The drug is encased in liposomes, which helps to extend the life of the drug that is being distributed. Liposomes are self-assembling, spherical, closed colloidal structures that are composed of lipid bilayers that surround an aqueous space. The liposomes also help to increase the functionality and it helps to decrease the damage that the drug does to the heart muscles specifically.
  • Onivyde, liposome encapsulated irinotecan to treat metastatic pancreatic cancer, was approved by FDA in October 2015.

Cancer

Preclinical research

Existing and potential drug nanocarriers have been reviewed.

Nanoparticles have high surface area to volume ratio. This allows for many functional groups to be attached to a nanoparticle, which can seek out and bind to certain tumor cells. Additionally, the small size of nanoparticles (5 to 100 nanometers), allows them to preferentially accumulate at tumor sites (because tumors lack an effective lymphatic drainage system). Limitations to conventional cancer chemotherapy include drug resistance, lack of selectivity, and lack of solubility.

Imaging

In vivo imaging is another area where tools and devices are being developed. Using nanoparticle contrast agents, images such as ultrasound and MRI have a favorable distribution and improved contrast. In cardiovascular imaging, nanoparticles have potential to aid visualization of blood pooling, ischemia, angiogenesis, atherosclerosis, and focal areas where inflammation is present.

The small size of nanoparticles endows them with properties that can be very useful in oncology, particularly in imaging. Quantum dots (nanoparticles with quantum confinement properties, such as size-tunable light emission), when used in conjunction with MRI (magnetic resonance imaging), can produce exceptional images of tumor sites. Nanoparticles of cadmium selenide glow when exposed to ultraviolet light. When injected, they seep into cancer tumors. The surgeon can see the glowing tumor, and use it as a guide for more accurate tumor removal.These nanoparticles are much brighter than organic dyes and only need one light source for excitation. This means that the use of fluorescent quantum dots could produce a higher contrast image and at a lower cost than today's organic dyes used as contrast media. The downside, however, is that quantum dots are usually made of quite toxic elements, but this concern may be addressed by use of fluorescent dopants.

Tracking movement can help determine how well drugs are being distributed or how substances are metabolized. It is difficult to track a small group of cells throughout the body, so scientists used to dye the cells. These dyes needed to be excited by light of a certain wavelength in order for them to light up. While different color dyes absorb different frequencies of light, there was a need for as many light sources as cells. A way around this problem is with luminescent tags. These tags are quantum dots attached to proteins that penetrate cell membranes. The dots can be random in size, can be made of bio-inert material, and they demonstrate the nanoscale property that color is size-dependent. As a result, sizes are selected so that the frequency of light used to make a group of quantum dots fluoresce is an even multiple of the frequency required to make another group incandesce. Then both groups can be lit with a single light source. They have also found a way to insert nanoparticles into the affected parts of the body so that those parts of the body will glow showing the tumor growth or shrinkage or also organ trouble.

Sensing

Nanotechnology-on-a-chip is one more dimension of lab-on-a-chip technology. Magnetic nanoparticles, bound to a suitable antibody, are used to label specific molecules, structures or microorganisms. In particular silica nanoparticles are inert from the photophysical point of view and might accumulate a large number of dye(s) within the nanoparticle shell. Gold nanoparticles tagged with short segments of DNA can be used for detection of genetic sequence in a sample. Multicolor optical coding for biological assays has been achieved by embedding different-sized quantum dots into polymeric microbeads. Nanopore technology for analysis of nucleic acids converts strings of nucleotides directly into electronic signatures.

Sensor test chips containing thousands of nanowires, able to detect proteins and other biomarkers left behind by cancer cells, could enable the detection and diagnosis of cancer in the early stages from a few drops of a patient's blood. Nanotechnology is helping to advance the use of arthroscopes, which are pencil-sized devices that are used in surgeries with lights and cameras so surgeons can do the surgeries with smaller incisions. The smaller the incisions the faster the healing time which is better for the patients. It is also helping to find a way to make an arthroscope smaller than a strand of hair.

Research on nanoelectronics-based cancer diagnostics could lead to tests that can be done in pharmacies. The results promise to be highly accurate and the product promises to be inexpensive. They could take a very small amount of blood and detect cancer anywhere in the body in about five minutes, with a sensitivity that is a thousand times better a conventional laboratory test. These devices that are built with nanowires to detect cancer proteins; each nanowire detector is primed to be sensitive to a different cancer marker. The biggest advantage of the nanowire detectors is that they could test for anywhere from ten to one hundred similar medical conditions without adding cost to the testing device. Nanotechnology has also helped to personalize oncology for the detection, diagnosis, and treatment of cancer. It is now able to be tailored to each individual’s tumor for better performance. They have found ways that they will be able to target a specific part of the body that is being affected by cancer.

Blood purification

Magnetic micro particles are proven research instruments for the separation of cells and proteins from complex media. The technology is available under the name Magnetic-activated cell sorting or Dynabeads among others. More recently it was shown in animal models that magnetic nanoparticles can be used for the removal of various noxious compounds including toxins, pathogens, and proteins from whole blood in an extracorporeal circuit similar to dialysis. In contrast to dialysis, which works on the principle of the size related diffusion of solutes and ultrafiltration of fluid across a semi-permeable membrane, the purification with nanoparticles allows specific targeting of substances. Additionally larger compounds which are commonly not dialyzable can be removed.

The purification process is based on functionalized iron oxide or carbon coated metal nanoparticles with ferromagnetic or superparamagnetic properties. Binding agents such as proteins, antibodies, antibiotics, or synthetic ligands are covalently linked to the particle surface. These binding agents are able to interact with target species forming an agglomerate. Applying an external magnetic field gradient allows exerting a force on the nanoparticles. Hence the particles can be separated from the bulk fluid, thereby cleaning it from the contaminants.

The small size (< 100 nm) and large surface area of functionalized nanomagnets leads to advantageous properties compared to hemoperfusion, which is a clinically used technique for the purification of blood and is based on surface adsorption. These advantages are high loading and accessible for binding agents, high selectivity towards the target compound, fast diffusion, small hydrodynamic resistance, and low dosage.

This approach offers new therapeutic possibilities for the treatment of systemic infections such as sepsis by directly removing the pathogen. It can also be used to selectively remove cytokines or endotoxins or for the dialysis of compounds which are not accessible by traditional dialysis methods. However the technology is still in a preclinical phase and first clinical trials are not expected before 2017.

Tissue engineering

Nanotechnology may be used as part of tissue engineering to help reproduce or repair or reshape damaged tissue using suitable nanomaterial-based scaffolds and growth factors. Tissue engineering if successful may replace conventional treatments like organ transplants or artificial implants. Nanoparticles such as graphene, carbon nanotubes, molybdenum disulfide and tungsten disulfide are being used as reinforcing agents to fabricate mechanically strong biodegradable polymeric nanocomposites for bone tissue engineering applications. The addition of these nanoparticles in the polymer matrix at low concentrations (~0.2 weight %) leads to significant improvements in the compressive and flexural mechanical properties of polymeric nanocomposites. Potentially, these nanocomposites may be used as a novel, mechanically strong, light weight composite as bone implants.

For example, a flesh welder was demonstrated to fuse two pieces of chicken meat into a single piece using a suspension of gold-coated nanoshells activated by an infrared laser. This could be used to weld arteries during surgery. Another example is nanonephrology, the use of nanomedicine on the kidney.

Medical devices

Neuro-electronic interfacing is a visionary goal dealing with the construction of nanodevices that will permit computers to be joined and linked to the nervous system. This idea requires the building of a molecular structure that will permit control and detection of nerve impulses by an external computer. A refuelable strategy implies energy is refilled continuously or periodically with external sonic, chemical, tethered, magnetic, or biological electrical sources, while a nonrefuelable strategy implies that all power is drawn from internal energy storage which would stop when all energy is drained. A nanoscale enzymatic biofuel cell for self-powered nanodevices have been developed that uses glucose from biofluids including human blood and watermelons. One limitation to this innovation is the fact that electrical interference or leakage or overheating from power consumption is possible. The wiring of the structure is extremely difficult because they must be positioned precisely in the nervous system. The structures that will provide the interface must also be compatible with the body's immune system.

Molecular nanotechnology is a speculative subfield of nanotechnology regarding the possibility of engineering molecular assemblers, machines which could re-order matter at a molecular or atomic scale. Nanomedicine would make use of these nanorobots, introduced into the body, to repair or detect damages and infections. Molecular nanotechnology is highly theoretical, seeking to anticipate what inventions nanotechnology might yield and to propose an agenda for future inquiry. The proposed elements of molecular nanotechnology, such as molecular assemblers and nanorobots are far beyond current capabilities. Future advances in nanomedicine could give rise to life extension through the repair of many processes thought to be responsible for aging. K. Eric Drexler, one of the founders of nanotechnology, postulated cell repair machines, including ones operating within cells and utilizing as yet hypothetical molecular machines, in his 1986 book Engines of Creation, with the first technical discussion of medical nanorobots by Robert Freitas appearing in 1999. Raymond Kurzweil, a futurist and transhumanist, stated in his book The Singularity Is Near that he believes that advanced medical nanorobotics could completely remedy the effects of aging by 2030. According to Richard Feynman, it was his former graduate student and collaborator Albert Hibbs who originally suggested to him (circa 1959) the idea of a medical use for Feynman's theoretical micromachines (see nanotechnology). Hibbs suggested that certain repair machines might one day be reduced in size to the point that it would, in theory, be possible to (as Feynman put it) "swallow the doctor". The idea was incorporated into Feynman's 1959 essay There's Plenty of Room at the Bottom.

Bayesian inference

From Wikipedia, the free encyclopedia https://en.wikipedia.org/wiki/Bayesian_inference Bayesian inference ( / ...