Anti-capitalism

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"Pyramid of Capitalist System", a 1911 Industrial Workers of the World poster

Socialism

Karl Marx, considered by many as one of the founding fathers of anti-capitalist thought

Socialism advocates public or direct worker ownership and administration of the means of production and allocation of resources, and a society characterized by equal access to resources for all individuals, with an egalitarian method of compensation.

1. A theory or policy of social organisation which aims at or advocates the ownership and democratic control of the means of production, by workers or the community as a whole, and their administration or distribution in the interests of all.
2. Socialists argue for a worker cooperative/community economy, or the commanding heights of the economy, with democratic control by the people over the state, although there have been some undemocratic philosophies. "State" or "worker cooperative" ownership is in fundamental opposition to "private" ownership of means of production, which is a defining feature of capitalism. Most socialists argue that capitalism unfairly concentrates power, wealth and profit, among a small segment of society that controls capital and derives its wealth through exploitation.

Socialists argue that the accumulation of capital generates waste through externalities that require costly corrective regulatory measures. They also point out that this process generates wasteful industries and practices that exist only to generate sufficient demand for products to be sold at a profit (such as high-pressure advertisement); thereby creating rather than satisfying economic demand.

Socialists argue that capitalism consists of irrational activity, such as the purchasing of commodities only to sell at a later time when their price appreciates, rather than for consumption, even if the commodity cannot be sold at a profit to individuals in need; they argue that making money, or accumulation of capital, does not correspond to the satisfaction of demand.

Private ownership imposes constraints on planning, leading to inaccessible economic decisions that result in immoral production, unemployment and a tremendous waste of material resources during crisis of overproduction. According to socialists, private property in the means of production becomes obsolete when it concentrates into centralized, socialized institutions based on private appropriation of revenue (but based on cooperative work and internal planning in allocation of inputs) until the role of the capitalist becomes redundant. With no need for capital accumulation and a class of owners, private property in the means of production is perceived as being an outdated form of economic organization that should be replaced by a free association of individuals based on public or common ownership of these socialized assets. Socialists view private property relations as limiting the potential of productive forces in the economy.

Early socialists (Utopian socialists and Ricardian socialists) criticized capitalism for concentrating power and wealth within a small segment of society, and for not utilising available technology and resources to their maximum potential in the interests of the public.

Anarchism and libertarian socialism

Emma Goldman famously denounced wage slavery by saying: "The only difference is that you are hired slaves instead of block slaves."

For the influential German individualist anarchist philosopher Max Stirner, "private property is a spook" which "lives by the grace of law" and it "becomes 'mine' only by effect of the law". In other words, private property exists purely "through the protection of the State, through the State's grace." Recognising its need for state protection, Stirner argued that "[i]t need not make any difference to the 'good citizens' who protects them and their principles, whether an absolute King or a constitutional one, a republic, if only they are protected. And what is their principle, whose protector they always 'love'? Not that of labour", rather it is "interest-bearing possession ... labouring capital, therefore ... labour certainly, yet little or none at all of one's own, but labour of capital and of the—subject labourers." French anarchist Pierre-Joseph Proudhon opposed government privilege that protects capitalist, banking and land interests, and the accumulation or acquisition of property (and any form of coercion that led to it) which he believed hampers competition and keeps wealth in the hands of the few. The Spanish individualist anarchist Miguel Giménez Igualada saw:

capitalism [as] an effect of government; the disappearance of government means capitalism falls from its pedestal vertiginously...That which we call capitalism is not something else but a product of the State, within which the only thing that is being pushed forward is profit, good or badly acquired. And so to fight against capitalism is a pointless task, since be it State capitalism or Enterprise capitalism, as long as Government exists, exploiting capital will exist. The fight, but of consciousness, is against the State.

Within anarchism there emerged a critique of wage slavery, which refers to a situation perceived as quasi-voluntary slavery, where a person's livelihood depends on wages, especially when the dependence is total and immediate. It is a negatively connoted term used to draw an analogy between slavery and wage labor by focusing on similarities between owning and renting a person. The term wage slavery has been used to criticize economic exploitation and social stratification, with the former seen primarily as unequal bargaining power between labor and capital (particularly when workers are paid comparatively low wages, e.g. in sweatshops), and the latter as a lack of workers' self-management, fulfilling job choices and leisure in an economy. Libertarian socialists believe if freedom is valued, then society must work towards a system in which individuals have the power to decide economic issues along with political issues. Libertarian socialists seek to replace unjustified authority with direct democracy, voluntary federation, and popular autonomy in all aspects of life, including physical communities and economic enterprises. With the advent of the Industrial Revolution, thinkers such as Proudhon and Marx elaborated the comparison between wage labor and slavery in the context of a critique of societal property not intended for active personal use, Luddites emphasized the dehumanization brought about by machines, while later American anarchist Emma Goldman famously denounced wage slavery by saying: "The only difference is that you are hired slaves instead of block slaves." Goldman believed that the economic system of capitalism was incompatible with human liberty. "The only demand that property recognizes," she wrote in Anarchism and Other Essays, "is its own gluttonous appetite for greater wealth, because wealth means power; the power to subdue, to crush, to exploit, the power to enslave, to outrage, to degrade." She also argued that capitalism dehumanized workers, "turning the producer into a mere particle of a machine, with less will and decision than his master of steel and iron."

Noam Chomsky contends that there is little moral difference between chattel slavery and renting one's self to an owner or "wage slavery". He feels that it is an attack on personal integrity that undermines individual freedom. He holds that workers should own and control their workplace. Many libertarian socialists argue that large-scale voluntary associations should manage industrial manufacture, while workers retain rights to the individual products of their labor. As such, they see a distinction between the concepts of "private property" and "personal possession". Whereas "private property" grants an individual exclusive control over a thing whether it is in use or not, and regardless of its productive capacity, "possession" grants no rights to things that are not in use.

In addition to individualist anarchist Benjamin Tucker's "big four" monopolies (land, money, tariffs, and patents), Kevin Carson argues that the state has also transferred wealth to the wealthy by subsidizing organizational centralization, in the form of transportation and communication subsidies. He believes that Tucker overlooked this issue due to Tucker's focus on individual market transactions, whereas Carson also focuses on organizational issues. Carson holds that "capitalism, arising as a new class society directly from the old class society of the Middle Ages, was founded on an act of robbery as massive as the earlier feudal conquest of the land. It has been sustained to the present by continual state intervention to protect its system of privilege without which its survival is unimaginable." Carson coined the pejorative term "vulgar libertarianism", a phrase that describes the use of a free market rhetoric in defense of corporate capitalism and economic inequality. According to Carson, the term is derived from the phrase "vulgar political economy", which Karl Marx described as an economic order that "deliberately becomes increasingly apologetic and makes strenuous attempts to talk out of existence the ideas which contain the contradictions [existing in economic life]."

Marxism

Capital: Critique of Political Economy, by Karl Marx, is a critical analysis of political economy, meant to reveal the economic laws of the capitalist mode of production.

If we have chosen the position in life in which we can most of all work for mankind, no burdens can bow us down, because they are sacrifices for the benefit of all; then we shall experience no petty, limited, selfish joy, but our happiness will belong to millions, our deeds will live on quietly but perpetually at work, and over our ashes will be shed the hot tears of noble people.

— Karl Marx, 1835

Karl Marx saw capitalism as a historical stage, once progressive but which would eventually stagnate due to internal contradictions and would eventually be followed by socialism. Marx claimed that capitalism was nothing more than a necessary stepping stone for the progression of man, which would then face a political revolution before embracing the classless society. Marxists define capital as "a social, economic relation" between people (rather than between people and things). In this sense they seek to abolish capital. They believe that private ownership of the means of production enriches capitalists (owners of capital) at the expense of workers ("the rich get richer, and the poor get poorer"). In brief, they argue that the owners of the means of production do not work and therefore exploit the workerforce. In Karl Marx's view, the capitalists would eventually accumulate more and more capital, impoverishing the working class, and creating the social conditions for a revolution that would overthrow the institutions of capitalism. Private ownership over the means of production and distribution is seen as a dependency of non-owning classes on the ruling class, and ultimately a source of restriction of human freedom.

Barter

Barter is a system of exchange where goods or services are directly exchanged for other goods or services without using a medium of exchange, such as money. It is distinguishable from gift economies in many ways; one of them is that the reciprocal exchange is immediate and not delayed in time. It is usually bilateral, but may be multilateral (i.e., mediated through barter organizations) and, in most developed countries, usually only exists parallel to monetary systems to a very limited extent. Barter, as a replacement for money as the method of exchange, is used in times of monetary crisis, such as when the currency may be either unstable (e.g., hyperinflation or deflationary spiral) or simply unavailable for conducting commerce. Bartering could be considered a social starting point towards an anti-capitalist system, by negating the need for a medium of exchange.

Wage slavery

Wage slavery refers to a situation where a person's livelihood depends on wages or a salary, especially when the dependence is total and immediate. It is a pejorative term used to draw an analogy between slavery and wage labor by focusing on similarities between owning and renting a person.

The term wage slavery has been used to criticize exploitation of labour and social stratification, with the former seen primarily as unequal bargaining power between labor and capital (particularly when workers are paid comparatively low wages, e.g. in sweatshops), and the latter as a lack of workers' self-management, fulfilling job choices, and leisure in an economy. The criticism of social stratification covers a wider range of employment choices bound by the pressures of a hierarchical society to perform otherwise unfulfilling work that deprives humans of their "species character" not only under threat of starvation or poverty, but also of social stigma and status diminution. It has been argued by some centre-left and left leaning activists that the economy of the contemporary United States constitutes a softer form of wage slavery, in which conditions are not grinding, but nonetheless not conducive to individual economic progress.

Behavioral neuroscience

From Wikipedia, the free encyclopedia

Behavioral neuroscience, also known as biological psychology, biopsychology, or psychobiology, is the application of the principles of biology to the study of physiological, genetic, and developmental mechanisms of behavior in humans and other animals.

History

Behavioral neuroscience as a scientific discipline emerged from a variety of scientific and philosophical traditions in the 18th and 19th centuries. In philosophy, people like René Descartes proposed physical models to explain animal as well as human behavior. Descartes suggested that the pineal gland, a midline unpaired structure in the brain of many organisms, was the point of contact between mind and body. Descartes also elaborated on a theory in which the pneumatics of bodily fluids could explain reflexes and other motor behavior. This theory was inspired by moving statues in a garden in Paris. Electrical stimulation and lesions can also show the affect of motor behavior of humans. They can record the electrical activity of actions, hormones, chemicals and effects drugs have in the body system all which affect ones daily behavior.

William James

Other philosophers also helped give birth to psychology. One of the earliest textbooks in the new field, The Principles of Psychology by William James, argues that the scientific study of psychology should be grounded in an understanding of biology.

The emergence of psychology and behavioral neuroscience as legitimate sciences can be traced from the emergence of physiology from anatomy, particularly neuroanatomy. Physiologists conducted experiments on living organisms, a practice that was distrusted by the dominant anatomists of the 18th and 19th centuries. The influential work of Claude Bernard, Charles Bell, and William Harvey helped to convince the scientific community that reliable data could be obtained from living subjects.

Even before the 18th and 19th century, behavioral neuroscience was beginning to take form as far back as 1700 B.C. The question that seems to continually arise is: what is the connection between the mind and body? The debate is formally referred to as the mind-body problem. There are two major schools of thought that attempt to resolve the mind–body problem; monism and dualism. Plato and Aristotle are two of several philosophers who participated in this debate. Plato believed that the brain was where all mental thought and processes happened. In contrast, Aristotle believed the brain served the purpose of cooling down the emotions derived from the heart. The mind-body problem was a stepping stone toward attempting to understand the connection between the mind and body.

Another debate arose about localization of function or functional specialization versus equipotentiality which played a significant role in the development in behavioral neuroscience. As a result of localization of function research, many famous people found within psychology have come to various different conclusions. Wilder Penfield was able to develop a map of the cerebral cortex through studying epileptic patients along with Rassmussen. Research on localization of function has led behavioral neuroscientists to a better understanding of which parts of the brain control behavior. This is best exemplified through the case study of Phineas Gage.

The term "psychobiology" has been used in a variety of contexts, emphasizing the importance of biology, which is the discipline that studies organic, neural and cellular modifications in behavior, plasticity in neuroscience, and biological diseases in all aspects, in addition, biology focuses and analyzes behavior and all the subjects it is concerned about, from a scientific point of view. In this context, psychology helps as a complementary, but important discipline in the neurobiological sciences. The role of psychology in this questions is that of a social tool that backs up the main or strongest biological science. The term "psychobiology" was first used in its modern sense by Knight Dunlap in his book An Outline of Psychobiology (1914). Dunlap also was the founder and editor-in-chief of the journal Psychobiology. In the announcement of that journal, Dunlap writes that the journal will publish research "...bearing on the interconnection of mental and physiological functions", which describes the field of behavioral neuroscience even in its modern sense.

Relationship to other fields of psychology and biology

In many cases, humans may serve as experimental subjects in behavioral neuroscience experiments; however, a great deal of the experimental literature in behavioral neuroscience comes from the study of non-human species, most frequently rats, mice, and monkeys. As a result, a critical assumption in behavioral neuroscience is that organisms share biological and behavioral similarities, enough to permit extrapolations across species. This allies behavioral neuroscience closely with comparative psychology, evolutionary psychology, evolutionary biology, and neurobiology. Behavioral neuroscience also has paradigmatic and methodological similarities to neuropsychology, which relies heavily on the study of the behavior of humans with nervous system dysfunction (i.e., a non-experimentally based biological manipulation).

Synonyms for behavioral neuroscience include biopsychology, biological psychology, and psychobiology. Physiological psychology is a subfield of behavioral neuroscience, with an appropriately narrower definition.

Research methods

The distinguishing characteristic of a behavioral neuroscience experiment is that either the independent variable of the experiment is biological, or some dependent variable is biological. In other words, the nervous system of the organism under study is permanently or temporarily altered, or some aspect of the nervous system is measured (usually to be related to a behavioral variable).

Disabling or decreasing neural function

• The part of the picture emphasized shows the lesion in the brain. This type of lesion can be removed through surgery.
  • Surgical lesions – Neural tissue is destroyed by removing it surgically.
  • Electrolytic lesions – Neural tissue is destroyed through the application of electrical shock trauma.
  • Chemical lesions – Neural tissue is destroyed by the infusion of a neurotoxin.
  • Temporary lesions – Neural tissue is temporarily disabled by cooling or by the use of anesthetics such as tetrodotoxin.
• Transcranial magnetic stimulation – A new technique usually used with human subjects in which a magnetic coil applied to the scalp causes unsystematic electrical activity in nearby cortical neurons which can be experimentally analyzed as a functional lesion.
• Synthetic ligand injection – A receptor activated solely by a synthetic ligand (RASSL) or Designer Receptor Exclusively Activated by Designer Drugs (DREADD), permits spatial and temporal control of G protein signaling in vivo. These systems utilize G protein-coupled receptors (GPCR) engineered to respond exclusively to synthetic small molecules ligands, like clozapine N-oxide (CNO), and not to their natural ligand(s). RASSL's represent a GPCR-based chemogenetic tool. These synthetic ligands upon activation can decrease neural function by G-protein activation. This can with Potassium attenuating neural activity.
• Psychopharmacological manipulations – A chemical receptor antagonist induces neural activity by interfering with neurotransmission. Antagonists can be delivered systemically (such as by intravenous injection) or locally (intracerebrally) during a surgical procedure into the ventricles or into specific brain structures. For example, NMDA antagonist AP5 has been shown to inhibit the initiation of long term potentiation of excitatory synaptic transmission (in rodent fear conditioning) which is believed to be a vital mechanism in learning and memory.
• Optogenetic inhibition – A light activated inhibitory protein is expressed in cells of interest. Powerful millisecond timescale neuronal inhibition is instigated upon stimulation by the appropriate frequency of light delivered via fiber optics or implanted LEDs in the case of vertebrates, or via external illumination for small, sufficiently translucent invertebrates. Bacterial Halorhodopsins or Proton pumps are the two classes of proteins used for inhibitory optogenetics, achieving inhibition by increasing cytoplasmic levels of halides (Cl⁻
  ) or decreasing the cytoplasmic concentration of protons, respectively.

Enhancing neural function

• Electrical stimulation – A classic method in which neural activity is enhanced by application of a small electric current (too small to cause significant cell death).
• Psychopharmacological manipulations – A chemical receptor agonist facilitates neural activity by enhancing or replacing endogenous neurotransmitters. Agonists can be delivered systemically (such as by intravenous injection) or locally (intracerebrally) during a surgical procedure.
• Synthetic Ligand Injection – Likewise, G_q-DREADDs can be used to modulate cellular function by innervation of brain regions such as Hippocampus. This innervation results in the amplification of γ-rhythms, which increases motor activity.
• Transcranial magnetic stimulation – In some cases (for example, studies of motor cortex), this technique can be analyzed as having a stimulatory effect (rather than as a functional lesion).
• Optogenetic excitation – A light activated excitatory protein is expressed in select cells. Channelrhodopsin-2 (ChR2), a light activated cation channel, was the first bacterial opsin shown to excite neurons in response to light, though a number of new excitatory optogenetic tools have now been generated by improving and imparting novel properties to ChR2.

Measuring neural activity

• PET brain scans can show chemical differences in the brain between addicts and non-addicts. You can see the normal images in the top row come from non addict while people who have addicting disorders have scans that look more abnormal.
  PET - Positron Emission Tomography detects particles called photons using a 3-D nuclear medicine examination. These particles are emitted by injections of radioisotopes such as fluorine. PET imaging reveal the pathological processes which predict anatomic changes making it important for detecting, diagnosing and characterising many pathologies
• Electroencephalography – Or EEG; and the derivative technique of event-related potentials, in which scalp electrodes monitor the average activity of neurons in the cortex (again, used most frequently with human subjects). This technique uses different types of electrodes for recording systems such as needle electrodes and saline-based electrodes. EEG allows for the investigation of mental disorders, sleep disorders and physiology. It can monitor brain development and cognitive engagement.
• Functional neuroanatomy – A more complex counterpart of phrenology. The expression of some anatomical marker is taken to reflect neural activity. For example, the expression of immediate early genes is thought to be caused by vigorous neural activity. Likewise, the injection of 2-deoxyglucose prior to some behavioral task can be followed by anatomical localization of that chemical; it is taken up by neurons that are electrically active.
• MEG – Magnetoencephalography shows the functioning of the human brain through the measurement of electromagnetic activity. Measuring the magnetic fields created by the electric current flowing within the neurons identifies brain activity associated with various human functions in real time, with millimeter spatial accuracy. Clinicians can noninvasively obtain data to help them assess neurological disorders and plan surgical treatments.

Genetic techniques

• QTL mapping – The influence of a gene in some behavior can be statistically inferred by studying inbred strains of some species, most commonly mice. The recent sequencing of the genome of many species, most notably mice, has facilitated this technique.
• Selective breeding – Organisms, often mice, may be bred selectively among inbred strains to create a recombinant congenic strain. This might be done to isolate an experimentally interesting stretch of DNA derived from one strain on the background genome of another strain to allow stronger inferences about the role of that stretch of DNA.
• Genetic engineering – The genome may also be experimentally-manipulated; for example, knockout mice can be engineered to lack a particular gene, or a gene may be expressed in a strain which does not normally do so (the 'transgenic'). Advanced techniques may also permit the expression or suppression of a gene to occur by injection of some regulating chemical.

Other research methods

Computational models - Using a computer to formulate real-world problems to develop solutions. Although this method is often focused in computer science, it has begun to move towards other areas of study. For example, psychology is one of these areas. Computational models allow researchers in psychology to enhance their understanding of the functions and developments in nervous systems. Examples of methods include the modelling of neurons, networks and brain systems and theoretical analysis. Computational methods have a wide variety of roles including clarifying experiments, hypothesis testing and generating new insights. These techniques play an increasing role in the advancement of biological psychology.

Limitations and advantages

Different manipulations have advantages and limitations. Neural tissue destroyed as a primary consequence of a surgery, electric shock or neurotoxin can confound the results so that the physical trauma masks changes in the fundamental neurophysiological processes of interest. For example, when using an electrolytic probe to create a purposeful lesion in a distinct region of the rat brain, surrounding tissue can be affected: so, a change in behavior exhibited by the experimental group post-surgery is to some degree a result of damage to surrounding neural tissue, rather than by a lesion of a distinct brain region. Most genetic manipulation techniques are also considered permanent. Temporary lesions can be achieved with advanced in genetic manipulations, for example, certain genes can now be switched on and off with diet. Pharmacological manipulations also allow blocking of certain neurotransmitters temporarily as the function returns to its previous state after the drug has been metabolized.

Topic areas

In general, behavioral neuroscientists study similar themes and issues as academic psychologists, though limited by the need to use nonhuman animals. As a result, the bulk of literature in behavioral neuroscience deals with mental processes and behaviors that are shared across different animal models such as:

• Sensation and perception
• Motivated behavior (hunger, thirst, sex)
• Control of movement
• Learning and memory
• Sleep and biological rhythms
• Emotion

However, with increasing technical sophistication and with the development of more precise noninvasive methods that can be applied to human subjects, behavioral neuroscientists are beginning to contribute to other classical topic areas of psychology, philosophy, and linguistics, such as:

• Language
• Reasoning and decision making
• Consciousness

Behavioral neuroscience has also had a strong history of contributing to the understanding of medical disorders, including those that fall under the purview of clinical psychology and biological psychopathology (also known as abnormal psychology). Although animal models do not exist for all mental illnesses, the field has contributed important therapeutic data on a variety of conditions, including:

• Parkinson's disease, a degenerative disorder of the central nervous system that often impairs the sufferer's motor skills and speech.
• Huntington's disease, a rare inherited neurological disorder whose most obvious symptoms are abnormal body movements and a lack of coordination. It also affects a number of mental abilities and some aspects of personality.
• Alzheimer's disease, a neurodegenerative disease that, in its most common form, is found in people over the age of 65 and is characterized by progressive cognitive deterioration, together with declining activities of daily living and by neuropsychiatric symptoms or behavioral changes.
• Clinical depression, a common psychiatric disorder, characterized by a persistent lowering of mood, loss of interest in usual activities and diminished ability to experience pleasure.
• Schizophrenia, a psychiatric diagnosis that describes a mental illness characterized by impairments in the perception or expression of reality, most commonly manifesting as auditory hallucinations, paranoid or bizarre delusions or disorganized speech and thinking in the context of significant social or occupational dysfunction.
• Autism, a brain development disorder that impairs social interaction and communication, and causes restricted and repetitive behavior, all starting before a child is three years old.
• Anxiety, a physiological state characterized by cognitive, somatic, emotional, and behavioral components. These components combine to create the feelings that are typically recognized as fear, apprehension, or worry.
• Drug abuse, including alcoholism.

Lesions – A classic method in which a brain-region of interest is naturally or intentionally destroyed to observe any resulting changes such as degraded or enhanced performance on some behavioral measure. Lesions can be placed with relatively high accuracy "Thanks to a variety of brain 'atlases' which provide a map of brain regions in 3-dimensional "stereotactic coordinates.

Optical techniques – Optical methods for recording neuronal activity rely on methods that modify the optical properties of neurons in response to the cellular events associated with action potentials or neurotransmitter release.

• Voltage sensitive dyes (VSDs) were among the earliest method for optically detecting neuronal activity. VSDs commonly changed their fluorescent properties in response to a voltage change across the neuron's membrane, rendering membrane sub-threshold and supra-threshold (action potentials) electrical activity detectable. Genetically encoded voltage sensitive fluorescent proteins have also been developed.
• Calcium imaging relies on dyes or genetically encoded proteins that fluoresce upon binding to the calcium that is transiently present during an action potential.
• Synapto-pHluorin is a technique that relies on a fusion protein that combines a synaptic vesicle membrane protein and a pH sensitive fluorescent protein. Upon synaptic vesicle release, the chimeric protein is exposed to the higher pH of the synaptic cleft, causing a measurable change in fluorescence.

Single-unit recording – A method whereby an electrode is introduced into the brain of a living animal to detect electrical activity that is generated by the neurons adjacent to the electrode tip. Normally this is performed with sedated animals but sometimes it is performed on awake animals engaged in a behavioral event, such as a thirsty rat whisking a particular sandpaper grade previously paired with water in order to measure the corresponding patterns of neuronal firing at the decision point.

Multielectrode recording – The use of a bundle of fine electrodes to record the simultaneous activity of up to hundreds of neurons.

fMRI – Functional magnetic resonance imaging, a technique most frequently applied on human subjects, in which changes in cerebral blood flow can be detected in an MRI apparatus and are taken to indicate relative activity of larger scale brain regions (i.e., on the order of hundreds of thousands of neurons).

Gregor Mendel

From Wikipedia, the free encyclopedia

 

The Right Reverend Gregor Mendel O.S.A.
Born	Johann Mendel 20 July 1822 Heinzendorf bei Odrau, Silesia, Austrian Empire (now Hynčice, Czech Republic)
Died	6 January 1884 (aged 61) Brünn, Moravia, Austria-Hungary (now Brno, Czech Republic)
Nationality	Austrian
Alma mater	University of Olomouc University of Vienna
Known for	Creating the science of genetics
Scientific career
Fields	Genetics
Institutions	St Thomas's Abbey
Ecclesiastical career
Religion	Christianity
Church	Catholic Church
Ordained	25 December 1846

Gregor Johann Mendel (/ˈmɛndəl/; Czech: Řehoř Jan Mendel; 20 July 1822 – 6 January 1884) was a meteorologist, mathematician, biologist, Augustinian friar and abbot of St. Thomas' Abbey in Brno, Margraviate of Moravia. Mendel was born in a German-speaking family in the Silesian part of the Austrian Empire (today's Czech Republic) and gained posthumous recognition as the founder of the modern science of genetics. Though farmers had known for millennia that crossbreeding of animals and plants could favor certain desirable traits, Mendel's pea plant experiments conducted between 1856 and 1863 established many of the rules of heredity, now referred to as the laws of Mendelian inheritance.

Mendel worked with seven characteristics of pea plants: plant height, pod shape and color, seed shape and color, and flower position and color. Taking seed color as an example, Mendel showed that when a true-breeding yellow pea and a true-breeding green pea were cross-bred their offspring always produced yellow seeds. However, in the next generation, the green peas reappeared at a ratio of 1 green to 3 yellow. To explain this phenomenon, Mendel coined the terms "recessive" and "dominant" in reference to certain traits. In the preceding example, the green trait, which seems to have vanished in the first filial generation, is recessive and the yellow is dominant. He published his work in 1866, demonstrating the actions of invisible "factors"—now called genes—in predictably determining the traits of an organism.

The profound significance of Mendel's work was not recognized until the turn of the 20th century (more than three decades later) with the rediscovery of his laws. Erich von Tschermak, Hugo de Vries and Carl Correns independently verified several of Mendel's experimental findings in 1900, ushering in the modern age of genetics.

Life and career

Mendel was born into a German-speaking Czech family in Hynčice (Heinzendorf bei Odrau in German), at the Moravian-Silesian border, Austrian Empire (now a part of the Czech Republic). He was the son of Anton and Rosine (Schwirtlich) Mendel and had one older sister, Veronika, and one younger, Theresia. They lived and worked on a farm which had been owned by the Mendel family for at least 130 years (the house where Mendel was born is now a museum devoted to Mendel). During his childhood, Mendel worked as a gardener and studied beekeeping. As a young man, he attended gymnasium in Opava (called Troppau in German). He had to take four months off during his gymnasium studies due to illness. From 1840 to 1843, he studied practical and theoretical philosophy and physics at the Philosophical Institute of the University of Olomouc, taking another year off because of illness. He also struggled financially to pay for his studies, and Theresia gave him her dowry. Later he helped support her three sons, two of whom became doctors.

He became a monk in part because it enabled him to obtain an education without having to pay for it himself. As the son of a struggling farmer, the monastic life, in his words, spared him the "perpetual anxiety about a means of livelihood." Born Johann Mendel, he was given the name Gregor (Řehoř in Czech) when he joined the Augustinian monks.

When Mendel entered the Faculty of Philosophy, the Department of Natural History and Agriculture was headed by Johann Karl Nestler who conducted extensive research of hereditary traits of plants and animals, especially sheep. Upon recommendation of his physics teacher Friedrich Franz, Mendel entered the Augustinian St Thomas's Abbey in Brno (called Brünn in German) and began his training as a priest. Mendel worked as a substitute high school teacher. In 1850, he failed the oral part, the last of three parts, of his exams to become a certified high school teacher. In 1851, he was sent to the University of Vienna to study under the sponsorship of Abbot Cyril František Napp [cz] so that he could get more formal education. At Vienna, his professor of physics was Christian Doppler. Mendel returned to his abbey in 1853 as a teacher, principally of physics. In 1856, he took the exam to become a certified teacher and again failed the oral part. In 1867, he replaced Napp as abbot of the monastery.

After he was elevated as abbot in 1868, his scientific work largely ended, as Mendel became overburdened with administrative responsibilities, especially a dispute with the civil government over its attempt to impose special taxes on religious institutions. Mendel died on 6 January 1884, at the age of 61, in Brno, Moravia, Austria-Hungary (now Czech Republic), from chronic nephritis. Czech composer Leoš Janáček played the organ at his funeral. After his death, the succeeding abbot burned all papers in Mendel's collection, to mark an end to the disputes over taxation.

Contributions

Experiments on plant hybridization

Dominant and recessive phenotypes. (1) Parental generation. (2) F1 generation. (3) F2 generation.

Gregor Mendel, known as the "father of modern genetics", chose to study variation in plants in his monastery's 2 hectares (4.9 acres) experimental garden.

After initial experiments with pea plants, Mendel settled on studying seven traits that seemed to be inherited independently of other traits: seed shape, flower color, seed coat tint, pod shape, unripe pod color, flower location, and plant height. He first focused on seed shape, which was either angular or round. Between 1856 and 1863 Mendel cultivated and tested some 28,000 plants, the majority of which were pea plants (Pisum sativum). This study showed that, when true-breeding different varieties were crossed to each other (e.g., tall plants fertilized by short plants), in the second generation, one in four pea plants had purebred recessive traits, two out of four were hybrids, and one out of four were purebred dominant. His experiments led him to make two generalizations, the Law of Segregation and the Law of Independent Assortment, which later came to be known as Mendel's Laws of Inheritance.

Initial reception of Mendel's work

Mendel presented his paper, "Versuche über Pflanzenhybriden" ("Experiments on Plant Hybridization"), at two meetings of the Natural History Society of Brno in Moravia on 8 February and 8 March 1865. It generated a few favorable reports in local newspapers, but was ignored by the scientific community. When Mendel's paper was published in 1866 in Verhandlungen des naturforschenden Vereines in Brünn, it was seen as essentially about hybridization rather than inheritance, had little impact, and was only cited about three times over the next thirty-five years. His paper was criticized at the time, but is now considered a seminal work. Notably, Charles Darwin was not aware of Mendel's paper, and it is envisaged that if he had been aware of it, genetics as it exists now might have taken hold much earlier. Mendel's scientific biography thus provides an example of the failure of obscure, highly original innovators to receive the attention they deserve.

Rediscovery of Mendel's work

About forty scientists listened to Mendel's two groundbreaking lectures, but it would appear that they failed to understand his work. Later, he also carried on a correspondence with Carl Nägeli, one of the leading biologists of the time, but Nägeli too failed to appreciate Mendel's discoveries. At times, Mendel must have entertained doubts about his work, but not always: "My time will come," he reportedly told a friend, Gustav von Niessl.

During Mendel's lifetime, most biologists held the idea that all characteristics were passed to the next generation through blending inheritance, in which the traits from each parent are averaged. Instances of this phenomenon are now explained by the action of multiple genes with quantitative effects. Charles Darwin tried unsuccessfully to explain inheritance through a theory of pangenesis. It was not until the early 20th century that the importance of Mendel's ideas was realized.

By 1900, research aimed at finding a successful theory of discontinuous inheritance rather than blending inheritance led to independent duplication of his work by Hugo de Vries and Carl Correns, and the rediscovery of Mendel's writings and laws. Both acknowledged Mendel's priority, and it is thought probable that de Vries did not understand the results he had found until after reading Mendel. Though Erich von Tschermak was originally also credited with rediscovery, this is no longer accepted because he did not understand Mendel's laws. Though de Vries later lost interest in Mendelism, other biologists started to establish modern genetics as a science. All three of these researchers, each from a different country, published their rediscovery of Mendel's work within a two-month span in the spring of 1900.

Mendel's results were quickly replicated, and genetic linkage quickly worked out. Biologists flocked to the theory; even though it was not yet applicable to many phenomena, it sought to give a genotypic understanding of heredity which they felt was lacking in previous studies of heredity, which had focused on phenotypic approaches. Most prominent of these previous approaches was the biometric school of Karl Pearson and W. F. R. Weldon, which was based heavily on statistical studies of phenotype variation. The strongest opposition to this school came from William Bateson, who perhaps did the most in the early days of publicising the benefits of Mendel's theory (the word "genetics", and much of the discipline's other terminology, originated with Bateson). This debate between the biometricians and the Mendelians was extremely vigorous in the first two decades of the 20th century, with the biometricians claiming statistical and mathematical rigor, whereas the Mendelians claimed a better understanding of biology. Modern genetics shows that Mendelian heredity is in fact an inherently biological process, though not all genes of Mendel's experiments are yet understood.

In the end, the two approaches were combined, especially by work conducted by R. A. Fisher as early as 1918. The combination, in the 1930s and 1940s, of Mendelian genetics with Darwin's theory of natural selection resulted in the modern synthesis of evolutionary biology.

Other experiments

Mendel began his studies on heredity using mice. He was at St. Thomas's Abbey but his bishop did not like one of his friars studying animal sex, so Mendel switched to plants. Mendel also bred bees in a bee house that was built for him, using bee hives that he designed. He also studied astronomy and meteorology, founding the 'Austrian Meteorological Society' in 1865. The majority of his published works were related to meteorology.

Mendel also experimented with hawkweed (Hieracium) and honeybees. He published a report on his work with hawkweed, a group of plants of great interest to scientists at the time because of their diversity. However, the results of Mendel's inheritance study in hawkweeds was unlike his results for peas; the first generation was very variable and many of their offspring were identical to the maternal parent. In his correspondence with Carl Nägeli he discussed his results but was unable to explain them. It was not appreciated until the end of the nineteenth century that many hawkweed species were apomictic, producing most of their seeds through an asexual process.

None of his results on bees survived, except for a passing mention in the reports of Moravian Apiculture Society. All that is known definitely is that he used Cyprian and Carniolan bees, which were particularly aggressive to the annoyance of other monks and visitors of the monastery such that he was asked to get rid of them. Mendel, on the other hand, was fond of his bees, and referred to them as "my dearest little animals".

He also described novel plant species, and these are denoted with the botanical author abbreviation "Mendel".

Mendelian paradox

In 1936, Ronald Fisher, a prominent statistician and population geneticist, reconstructed Mendel's experiments, analyzed results from the F2 (second filial) generation and found the ratio of dominant to recessive phenotypes (e.g. yellow versus green peas; round versus wrinkled peas) to be implausibly and consistently too close to the expected ratio of 3 to 1. Fisher asserted that "the data of most, if not all, of the experiments have been falsified so as to agree closely with Mendel's expectations," Mendel's alleged observations, according to Fisher, were "abominable", "shocking", and "cooked".

Other scholars agree with Fisher that Mendel's various observations come uncomfortably close to Mendel's expectations. A. W. F. Edwards, for instance, remarks: "One can applaud the lucky gambler; but when he is lucky again tomorrow, and the next day, and the following day, one is entitled to become a little suspicious". Three other lines of evidence likewise lend support to the assertion that Mendel's results are indeed too good to be true.

Fisher's analysis gave rise to the Mendelian paradox: Mendel's reported data are, statistically speaking, too good to be true, yet "everything we know about Mendel suggests that he was unlikely to engage in either deliberate fraud or in unconscious adjustment of his observations." A number of writers have attempted to resolve this paradox.

One attempted explanation invokes confirmation bias. Fisher accused Mendel's experiments as "biased strongly in the direction of agreement with expectation ... to give the theory the benefit of doubt". In his 2004 article, J.W. Porteous concluded that Mendel's observations were indeed implausible. However, reproduction of the experiments has demonstrated that there is no real bias towards Mendel's data.

Another attempt to resolve the Mendelian paradox notes that a conflict may sometimes arise between the moral imperative of a bias-free recounting of one's factual observations and the even more important imperative of advancing scientific knowledge. Mendel might have felt compelled “to simplify his data in order to meet real, or feared, editorial objections.” Such an action could be justified on moral grounds (and hence provide a resolution to the Mendelian paradox), since the alternative—refusing to comply—might have retarded the growth of scientific knowledge. Similarly, like so many other obscure innovators of science, Mendel, a little known innovator of working-class background, had to “break through the cognitive paradigms and social prejudices of his audience. If such a breakthrough “could be best achieved by deliberately omitting some observations from his report and adjusting others to make them more palatable to his audience, such actions could be justified on moral grounds.”

Daniel L. Hartl and Daniel J. Fairbanks reject outright Fisher's statistical argument, suggesting that Fisher incorrectly interpreted Mendel's experiments. They find it likely that Mendel scored more than 10 progeny, and that the results matched the expectation. They conclude: "Fisher's allegation of deliberate falsification can finally be put to rest, because on closer analysis it has proved to be unsupported by convincing evidence." In 2008 Hartl and Fairbanks (with Allan Franklin and AWF Edwards) wrote a comprehensive book in which they concluded that there were no reasons to assert Mendel fabricated his results, nor that Fisher deliberately tried to diminish Mendel's legacy. Reassessment of Fisher's statistical analysis, according to these authors, also disproves the notion of confirmation bias in Mendel's results.

Nootropic

From Wikipedia, the free encyclopedia

 

Modafinil is a common nootropic

Nootropics (/noʊ.əˈtroʊpɪks/ noh-ə-TROHP-iks, or /noʊ.əˈtrɒpɪks/ noh-ə-TROP-iks) (colloquial: smart drugs and cognitive enhancers) are drugs, supplements, and other substances that are claimed to improve cognitive function, particularly executive functions, memory, creativity, or motivation, in healthy individuals.

The use of cognition-enhancing drugs by healthy individuals in the absence of a medical indication spans numerous controversial issues, including the ethics and fairness of their use, concerns over adverse effects, and the diversion of prescription drugs for non-medical uses. Nonetheless, the international sales of cognition-enhancing supplements have continued to grow over time, exceeding US$1 billion in 2015.

In 2018 in the United States, some nootropic supplements were identified as having misleading ingredients and illegal marketing. In 2019, the US Food and Drug Administration (FDA) and Federal Trade Commission (FTC) warned manufacturers and consumers about possible advertising fraud and marketing scams concerning nootropic supplements.

Etymology

The term "nootropic" is derived from the Ancient Greek words νόος (nóos) meaning "mind" and τροπή (tropḗ) meaning "a turning".

Illegal marketing claims

Nootropics are frequently advertised with unproven claims of effectiveness at improving cognition. The FDA and FTC warned manufacturers and consumers in 2019 about possible advertising fraud and marketing scams concerning nootropic supplement products. The FDA and FTC stated that some nootropic products had not been approved as a drug effective for any medical purpose, were not proven to be safe, and were illegally marketed in the United States under violation of the Federal Food, Drug, and Cosmetic Act.

Over the years 2010 to 2019, the FDA warned numerous supplement manufacturers about the illegal status of their products as unapproved drugs with no proven safety or efficacy at the doses recommended, together with misleading marketing.

Availability and prevalence

In 2008, the most commonly used class of drug was stimulants, such as caffeine. Manufacturers' marketing claims for dietary supplements are usually not formally tested and verified by independent entities.

In 2016, the American Medical Association adopted a policy to discourage prescriptions of nootropics for healthy people, on the basis that the cognitive effects appear to be highly variable among individuals, are dose-dependent, and limited or modest at best.

Use by students

The use of prescription stimulants is especially prevalent among students. Surveys suggest that 0.7–4.5% of German students have used cognitive enhancers in their lifetimes. Stimulants such as dimethylamylamine and methylphenidate are used on college campuses and by younger groups. Based upon studies of self-reported illicit stimulant use, 5–35% of college students use diverted ADHD stimulants, which are primarily used for enhancement of academic performance rather than as recreational drugs. Several factors positively and negatively influence an individual's willingness to use a drug for the purpose of enhancing cognitive performance. Among them are personal characteristics, drug characteristics, and characteristics of the social context.

Side effects

The main concern with pharmaceutical drugs is adverse effects, which also apply to nootropics with undefined effect. Long-term safety evidence is typically unavailable for nootropics. Racetams — piracetam and other compounds that are structurally related to piracetam — have few serious adverse effects and low toxicity, but there is little evidence that they enhance cognition in people having no cognitive impairments.

In the United States, dietary supplements may be marketed if the manufacturer can show that the supplement is generally recognized as safe, and if the manufacturer does not make any claims about using the supplement to treat or prevent any disease or condition; supplements that contain drugs or advertise health claims are illegal under US law.

Drugs

Central nervous system stimulants

Hebbian version of the Yerkes–Dodson law

Systematic reviews and meta-analyses of clinical human research using low doses of certain central nervous system stimulants found that these drugs enhance cognition in healthy people. In particular, the classes of stimulants that demonstrate cognition-enhancing effects in humans act as direct agonists or indirect agonists of dopamine receptor D₁, adrenoceptor A₂, or both types of receptor in the prefrontal cortex. Relatively high doses of stimulants cause cognitive deficits.

• Amphetamine – systematic reviews and meta-analyses report that low-dose amphetamine improves cognitive functions (e.g., inhibitory control, episodic memory, working memory, and aspects of attention) in healthy people and in individuals with ADHD. A 2014 systematic review noted that low doses of amphetamine also improve memory consolidation, in turn leading to improved recall of information in non-ADHD youth. It also improves task saliency (motivation to perform a task) and performance on tedious tasks that required a high degree of effort.
• Methylphenidate – a benzylpiperidine derivative that improves working memory, episodic memory, and inhibitory control, aspects of attention, and planning latency in healthy people. It also may improve task saliency and performance on tedious tasks. At above optimal doses, methylphenidate has off–target effects that decrease learning.
• Eugeroics (armodafinil and modafinil) – are classified as "wakefulness-promoting agents"; modafinil increases alertness, particularly in sleep-deprived individuals, and facilitates reasoning and problem solving in non-ADHD youth. In a systematic review of small, preliminary studies where the effects of modafinil were examined, when simple psychometric assessments were considered, modafinil intake enhanced executive function. Modafinil may not produce improvements in mood or motivation in sleep deprived or non-sleep deprived individuals.
• Caffeine – a meta-analysis found an increase in alertness and attentional performance.
• Nicotine – a meta-analysis of 41 clinical studies concluded that nicotine administration or smoking improves alerting and orienting attention and episodic and working memory and slightly improves fine motor performance.

Racetams

Racetams, such as piracetam, oxiracetam, phenylpiracetam, and aniracetam, are often marketed as cognitive enhancers and sold over the counter. A recent study found that piracetam supplements sold in the United States were inaccurately labeled. Racetams are often referred to as nootropics, but this property is not well established. The racetams have poorly understood mechanisms, although piracetam and aniracetam are known to act as positive allosteric modulators of AMPA receptors and appear to modulate cholinergic systems.

According to the US Food and Drug Administration,

"Piracetam is not a vitamin, mineral, amino acid, herb or other botanical, or dietary substance for use by humans to supplement the diet by increasing the total dietary intake. Further, piracetam is not a concentrate, metabolite, constituent, extract or combination of any such dietary ingredient. [...] Accordingly, these products are drugs, under section 201(g)(1)(C) of the Act, 21 U.S.C. § 321(g)(1)(C), because they are not foods and they are intended to affect the structure or any function of the body. Moreover, these products are new drugs as defined by section 201(p) of the Act, 21 U.S.C. § 321(p), because they are not generally recognized as safe and effective for use under the conditions prescribed, recommended, or suggested in their labeling."

Cholinergics

Some of the most widely-used nootropic substances are the cholinergics. These are typically compounds and analogues of choline. Choline is an essential nutrient needed for the synthesis of acetylcholine (a neurotransmitter), and phosphatidylcholine (a structural component of brain cell membranes).

• Citicoline - Compound consisting of choline and cytidine. Several meta-analyses found that it is likely effective for improving memory and learning in older people with mild cognitive decline, as well as in people who are recovering from a stroke. There is little evidence it enhances cognition in young, healthy people.
• Choline bitartrate - Choline bitartrate is a tartaric acid salt containing choline (41% choline by molecular weight). At least one meta-analysis has found choline bitartrate to be ineffective at improving any measure of cognitive performance.
• Alpha-GPC - L-Alpha glycerylphosphorylcholine has thus far only been studied in the context of cognitive performance alongside other substances such as caffeine. A more comprehensive meta-analysis is needed before any strong conclusions are made about Alpha-GPC's usefulness as a nootropic.

Miscellaneous

• Tolcapone – a systematic review noted that it improved verbal episodic memory and episodic memory encoding.
• Levodopa – a systematic review noted that it improved verbal episodic memory and episodic memory encoding.
• Atomoxetine – may improve working memory and attention when used at certain doses.
• Desipramine – may improve working memory and attention when used at certain doses.
• Nicergoline may improve human cognitive performance, including concentration, psychomotor performance, attention, reaction times, and other indicators of brain function.
• ISRIB enhanced spatial and fear-associated learning.

The cognitive enhancing effects of pramipexole, guanfacine, clonidine, and fexofenadine have been tested, but no significant cognition-enhancing effects in healthy individuals were found.

Psychedelic microdosing is the novel practice of using sub-threshold doses (microdoses) of psychedelic drugs in an attempt to improve mood and cognition. The efficacy of this has not been verified. In a study examining the qualitative reports of 278 microdosers the researchers found that there were mixed results among users. While some users reported positive effects such as improved mood and cognition, others paradoxically reported negative effects such as physiological discomfort and anxiety. In one of the only double-blind, randomized studies to date, those given microdoses of LSD did not perform better than those given the placebo on cognitive tasks.

Herbs

• Bacopa monnieri is used in Ayurvedic traditional medicine to improve memory. Meta-analysis and reviews of clinical studies found evidence that the herb may improve cognition. It is thought that Bacopa monnieri primarily works by stimulating neuron dendrite branching, thus facilitating inter-neural communication. This view is contested, with others suggesting that Bacopa monnieri's nootropic effects are the result of its status as an antioxidant and adaptogen.
• Panax ginseng – A review by the Cochrane Collaboration found that the results of its analysis "suggested improvement of some aspects of cognitive function, behavior and quality of life" but concluded that "there is a lack of convincing evidence to show a cognitive enhancing effect of Panax ginseng in healthy participants and no high quality evidence about its efficacy in patients with dementia."
• Ginkgo biloba – An extract of Ginkgo biloba leaf is marketed in dietary supplement form with claims it can enhance cognitive function in people without known cognitive problems, although there is no high-quality evidence to support such effects on memory or attention in healthy people.
• Salvia officinalis and lavandulaefolia (sage) – Some research has suggested certain extracts of Salvia officinalis may have positive effects on human brain function, but due to significant methodological problems, no firm conclusions can be drawn. The thujone present in Salvia extracts may be neurotoxic.
• Centella asiatica – A 2017 meta-analysis with 11 studies (5 RCTs with placebo, 6 using other herbs as a comparison group) showing no significant improvement in all cognitive function, however may have some use in improving mood and anger. Overall dosages were smaller than the typical 3 grams used traditionally.

History

The term "nootropic" was coined by Corneliu Giurgea in 1972 to describe a new classification of molecules that acted selectively towards the brain's higher-level integrative activity. In order for a product to qualify as a true nootropic, it must fulfill Giurgea's five criteria for the category. 1.It should aid with improvement in working memory and learning. 2.Supports brain function under hypoxic conditions or after electroconvulsive therapy. 3.Protection of the brain from physical or chemical toxicity. 4.Natural cognitive functions are enhanced. 5. It requires to be non-toxic to humans, without depression or stimulation of the brain. 

Nutrients and dietary supplements

A 2015 review found that use of omega-3 fatty acids, B vitamins, and vitamin E as nootropics was ineffective on cognitive function in normal middle-aged and older people.

• Omega-3 fatty acids: DHA and EPA – two Cochrane Collaboration reviews on the use of supplemental omega-3 fatty acids for ADHD and learning disorders conclude that there is limited evidence of treatment benefits for either disorder. Two other systematic reviews found no cognition-enhancing effects in the general population.
• Folate – no cognition-enhancing effects in middle-aged and older adults without folate deficiency.
• Vitamin B₆ – no cognition-enhancing effects in middle-aged and older adults without B6 deficiency.
• Vitamin B₁₂ – no cognition-enhancing effects in middle-aged and older adults without B12 deficiency.
• Vitamin E – no cognition-enhancing effects in middle-aged and older adults without vitamin E deficiency.
• L-Theanine – A 2014 systematic review and meta-analysis found that concurrent caffeine and L-theanine use had synergistic psychoactive effects that promoted alertness, attention, and task switching. These effects were most pronounced during the first hour post-dose. The European Food Safety Authority reported that there is insufficient information to determine if these effects exist when L-theanine is used without caffeine.