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Friday, June 5, 2026

Paranormal

From Wikipedia, the free encyclopedia
https://en.wikipedia.org/wiki/Paranormal

Paranormal events are purported or imagined phenomena described in popular culture, folklore, and other non-scientific bodies of knowledge, whose existence within these contexts is described as being beyond the scope of normal scientific understanding. Notable paranormal beliefs include those that pertain to extrasensory perceptions (for example, telepathy), and the pseudosciences of ghost hunting, cryptozoology, and ufology.

Proposals regarding the paranormal are different from scientific hypotheses, or speculations extrapolated from scientific evidence, because scientific ideas are grounded in empirical observations and experimental data gained through the scientific method. In contrast, those who argue for the existence of the paranormal explicitly do not base their arguments on empirical evidence but rather on anecdote, testimony, and suspicion. The standard scientific models give the explanation that what appears to be paranormal phenomena is usually a misinterpretation, misunderstanding, or anomalous variation of natural phenomena.

Etymology

The term paranormal has existed in the English language since at least 1920. The word consists of two parts: para and normal. The definition implies that the scientific explanation of the world around us is normal and anything that is above, beyond, or contrary to that is para.

Paranormal subjects

On the classification of paranormal subjects, psychologist Terence Hines said in his book Pseudoscience and the Paranormal (2003):

The paranormal can best be thought of as a subset of pseudoscience. What sets the paranormal apart from other pseudosciences is a reliance on explanations for alleged phenomena that are well outside the bounds of established science. Thus, paranormal phenomena include extrasensory perception (ESP), telekinesis, ghosts, poltergeists, life after death, reincarnation, faith healing, human auras, and so forth. The explanations for these allied phenomena are phrased in vague terms of "psychic forces", "human energy fields", and so on. This is in contrast to many pseudoscientific explanations for other nonparanormal phenomena, which, although very bad science, are still couched in acceptable scientific terms.

Ghost hunting

Ghost hunting is the investigation of locations that are reportedly haunted by ghosts. Typically, a ghost-hunting team will attempt to collect evidence supporting the existence of paranormal activity.

In traditional ghostlore and fiction featuring ghosts, a ghost is a manifestation of the spirit or soul of a person. Alternative theories expand on that idea and include belief in the ghosts of deceased animals. Sometimes the term "ghost" is used synonymously with any spirit or demon; however, in popular usage, the term typically refers to the spirit of a deceased person.

The belief in ghosts as souls of the departed is closely tied to the concept of animism, an ancient belief that attributed souls to everything in nature. As the 19th-century anthropologist George Frazer explained in his classic work, The Golden Bough (1890), souls were seen as the 'creature within' which animated the body. Although the human soul was sometimes symbolically or literally depicted in ancient cultures as a bird or other animal, it was widely held that the soul was an exact reproduction of the body in every feature, even down to the clothing worn by the person. This is depicted in artwork from various ancient cultures, including such works as the ancient Egyptian Book of the Dead (c. 1550 BCE), which shows deceased people in the afterlife appearing much as they did before death, including the style of dress.

Ufology

The possibility of extraterrestrial life is not, in itself, a paranormal subject. Many scientists are actively engaged in the search for unicellular life within the Solar System, carrying out studies on the surface of Mars and examining meteors that have fallen to Earth. Projects such as SETI are conducting an astronomical search for radio activity that would show evidence of intelligent life outside the Solar System. Scientific theories of how life developed on Earth allow for the possibility that life also developed on other planets. The paranormal aspect of extraterrestrial life centers largely around the belief in unidentified flying objects (UFOs) and the phenomena said to be associated with them.

Early in the history of UFO culture, believers divided themselves into two camps. The first held a rather conservative view of the phenomena, interpreting them as unexplained occurrences that merited serious study. They began calling themselves "ufologists" in the 1950s and felt that logical analysis of sighting reports would validate the notion of extraterrestrial visitation.

The second camp held a view that coupled ideas of extraterrestrial visitation with beliefs from existing quasi-religious movements. Typically, these individuals were enthusiasts of occultism and the paranormal. Many had backgrounds as active Theosophists or spiritualists, or were followers of other esoteric doctrines. In contemporary times, many of these beliefs have coalesced into New Age spiritual movements.

Both secular and spiritual believers describe UFOs as having abilities beyond what are considered possible according to known aerodynamic constraints and physical laws. The transitory events surrounding many UFO sightings preclude any opportunity for the repeat testing required by the scientific method. Acceptance of UFO theories by the larger scientific community is further hindered by the many possible hoaxes associated with UFO culture.

Cryptozoology

Cryptozoology is a pseudoscience and subculture that aims to prove the existence of entities from the folklore record, such as Bigfoot, chupacabras, or Mokele-mbembe. Cryptozoologists refer to these entities as cryptids, a term coined by the subculture.

Paranormal research

Approaching the paranormal from a research perspective is often difficult because of the lack of acceptable physical evidence from most of the purported phenomena. By definition, the paranormal (or supernatural) does not conform to conventional expectations of nature. Therefore, a phenomenon cannot be confirmed as paranormal using the scientific method because, if it could be, it would no longer fit the definition. (However, confirmation would result in the phenomenon being reclassified as part of science.) Despite this problem, studies on the paranormal are periodically conducted by researchers from various disciplines. Some researchers simply study the beliefs in the paranormal regardless of whether the phenomena are considered to objectively exist. This section deals with various approaches to the paranormal: anecdotal, experiment, al, and participant-observer approaches and the skeptical investigation approach.

Anecdotal approach

Charles Fort, 1920. Fort is perhaps the most widely known collector of paranormal stories.

An anecdotal approach to the paranormal involves the collection of stories told about the paranormal.

Charles Fort (1874–1932) is perhaps the best-known collector of paranormal anecdotes. Fort is said to have compiled as many as 40,000 notes on unexplained paranormal experiences, though there were no doubt many more. These notes came from what he called "the orthodox conventionality of Science", which were odd events originally reported in magazines and newspapers such as The Times and scientific journals such as Scientific American, Nature and Science. From this research Fort wrote seven books, though only four survive: The Book of the Damned (1919), New Lands (1923), Lo! (1931) and Wild Talents (1932); one book was written between New Lands and Lo!, but it was abandoned and absorbed into Lo!

Reported events that he collected include teleportation (a term Fort is generally credited with coining); poltergeist events; falls of frogs, fishes, and inorganic materials of an amazing range; crop circles; unaccountable noises and explosions; spontaneous fires; levitation; ball lightning (a term explicitly used by Fort); unidentified flying objects; mysterious appearances and disappearances; giant wheels of light in the oceans; and animals found outside their normal ranges (see phantom cat). He offered many reports of OOPArts, the abbreviation for "out of place" artifacts: strange items found in unlikely locations. He is perhaps the first person to explain strange human appearances and disappearances by the hypothesis of alien abduction and was an early proponent of the extraterrestrial hypothesis.

Fort is considered by many to be the father of modern paranormalism, which is the study of the paranormal.

The magazine Fortean Times continues Charles Fort's approach, regularly reporting anecdotal accounts of the paranormal.

Such anecdotal collections, lacking the reproducibility of empirical evidence, are not amenable to scientific investigation. The anecdotal approach is not a scientific approach to the paranormal because it leaves verification dependent on the credibility of the party presenting the evidence. Nevertheless, it is a common approach to investigating paranormal phenomena.

Parapsychology

Participant of a Ganzfeld experiment which proponents say may show evidence of telepathy.

Experimental investigation of the paranormal has been conducted by parapsychologists. J. B. Rhine popularized the now famous methodology of using card-guessing and dice-rolling experiments in a laboratory in the hopes of finding evidence of extrasensory perception. However, it was revealed that Rhine's experiments contained methodological flaws and procedural errors.

In 1957, the Parapsychological Association was formed as the preeminent society for parapsychologists. In 1969, they became affiliated with the American Association for the Advancement of Science. Criticisms of the field were focused in the creation (in 1976) of the Committee for the Scientific Investigation of Claims of the Paranormal (now called the Committee for Skeptical Inquiry) and its periodical, the Skeptical Inquirer. Eventually, more mainstream scientists became critical of parapsychology as an endeavor, and statements by the National Academies of Science and the National Science Foundation cast a pall on the claims of evidence for parapsychology. Today, many cite parapsychology as an example of a pseudoscience. Parapsychology has been criticized for continuing investigation despite being unable to provide convincing evidence for the existence of any psychic phenomena after more than a century of research.

By the 2000s, the status of paranormal research in the United States had greatly declined from its height in the 1970s, with the majority of work being privately funded and only a small amount of research being carried out in university laboratories. In 2007, Britain had a number of privately funded laboratories in university psychology departments. Publication remained limited to a small number of niche journals, and to date there have been no experimental results that have gained wide acceptance in the scientific community as valid evidence of the paranormal.

Participant-observer approach

A ghost hunter taking an EMF reading, which proponents claim may be connected to paranormal activity

While parapsychologists look for quantitative evidence of the paranormal in laboratories, a great number of people immerse themselves in qualitative research through participant-observer approaches to the paranormal. Participant-observer methodologies have overlaps with other essentially qualitative approaches, including phenomenological research that seeks largely to describe subjects as they are experienced, rather than to explain them.

Participant observation suggests that by immersing oneself in the subject that is being studied, a researcher is presumed to gain an understanding of the subject. Criticisms of participant observation as a data-gathering technique are similar to criticisms of other approaches to the paranormal, but also include an increased threat to the scientific objectivity of the researcher, unsystematic gathering of data, reliance on subjective measurement, and possible observer effects (i.e. observation may distort the observed behavior). Specific data-gathering methods, such as recording EMF (electromagnetic field) readings at haunted locations, have their own criticisms beyond those attributed to the participant-observer approach itself.

Participant observation, as an approach to the paranormal, has gained increased visibility and popularity through reality television programs like Ghost Hunters, and the formation of independent ghost hunting groups that advocate immersive research at alleged paranormal locations. One popular website for ghost hunting enthusiasts lists over 300 of these organizations throughout the United States and the United Kingdom.

Skeptical scientific investigation

James Randi was a well-known investigator of paranormal claims.

Scientific skeptics advocate critical investigation of claims of paranormal phenomena: applying the scientific method to reach a rational, scientific explanation of the phenomena to account for the paranormal claims, taking into account that alleged paranormal abilities and occurrences are sometimes hoaxes or misinterpretations of natural phenomena. A way of summarizing this method is by the application of Occam's razor, which suggests that the simpler solution is usually the correct one. The Committee for Skeptical Inquiry (CSI), formerly the Committee for the Scientific Investigation of Claims of the Paranormal (CSICOP), is an organization that aims to publicize the scientific, skeptical approach. It carries out investigations aimed at understanding paranormal reports in terms of scientific understanding, and publishes its results in the Skeptical Inquirer magazine.

CSI's Richard Wiseman draws attention to possible alternative explanations for perceived paranormal activity in his article, The Haunted Brain. While he recognizes that approximately 15% of people believe they have experienced an encounter with a ghost, he reports that only 1% report seeing a full-fledged ghost, while the rest report strange sensory stimuli, such as seeing fleeting shadows or wisps of smoke, or the sensation of hearing footsteps or feeling a presence. Wiseman makes the claim that, rather than experiencing paranormal activity, it is activity within our own brains that creates these strange sensations.

Michael Persinger proposed that ghostly experiences could be explained by stimulating the brain with weak magnetic fields. Swedish psychologist Pehr Granqvist and his team, attempting to replicate Persinger's research, determined that the paranormal sensations experienced by Persinger's subjects were merely the result of suggestion, and that brain stimulation with magnetic fields did not result in ghostly experiences. Oxford University Justin Barrett has theorized that "agency"—being able to figure out why people do what they do—is so important in everyday life that it is natural for our brains to work too hard at it, thereby detecting human or ghost-like behavior in everyday meaningless stimuli.

James Randi, an investigator with a background in illusion, felt that the simplest explanation for those claiming paranormal abilities is often trickery, illustrated by demonstrating that the spoon bending abilities of psychic Uri Geller can easily be duplicated by trained stage magicians. He was also the founder of the James Randi Educational Foundation and its million dollar challenge that offered a prize of $1,000,000 to anyone who could demonstrate evidence of any paranormal, supernatural or occult power or event, under test conditions agreed to by both parties. Despite many declarations of supernatural ability, the prize was never claimed.

Psychology

In "anomalistic psychology", paranormal phenomena have naturalistic explanations resulting from psychological and physical factors, which have sometimes given the impression of paranormal activity to some people, in fact, where there have been none. The psychologist David Marks wrote that paranormal phenomena can be explained by magical thinking, mental imagery, subjective validation, coincidence, hidden causes, and fraud. According to studies, some people tend to hold paranormal beliefs because they possess psychological traits that make them more likely to misattribute paranormal causation to normal experiences. Research has also discovered that cognitive bias is a factor underlying paranormal belief.

Chris French, founder of the Anomalistic Psychology Research Unit.

Many studies have found a link between personality and psychopathology variables correlating with paranormal belief. Some studies have also shown that fantasy proneness correlates positively with paranormal belief.

Bainbridge (1978) and Wuthnow (1976) found that the most susceptible people to paranormal belief are those who are poorly educated, unemployed, or have roles that rank low among social values. The alienation of these people due to their status in society is said to encourage them to appeal to paranormal or magical beliefs.

Research has associated paranormal belief with low cognitive ability, low IQ, and a lack of science educationIntelligent and highly educated participants involved in surveys have proven to have less paranormal belief. Tobacyk (1984) and Messer and Griggs (1989) discovered that college students with better grades have less belief in the paranormal.

In a case study (Gow, 2004) involving 167 participants, the findings revealed that psychological absorption and dissociation were higher for believers in the paranormal. Another study involving 100 students had revealed a positive correlation between paranormal belief and proneness to dissociation. A study (Williams et al. 2007) discovered that "neuroticism is fundamental to individual differences in paranormal belief, while paranormal belief is independent of extraversion and psychoticism". A correlation has been found between paranormal belief and irrational thinking.

In an experiment Wierzbicki (1985) reported a significant correlation between paranormal belief and the number of errors made on a syllogistic reasoning task, suggesting that believers in the paranormal have lower cognitive ability. A relationship between narcissistic personality and paranormal belief was discovered in a study involving the Australian Sheep-Goat Scale.

De Boer and Bierman wrote:

In his article 'Creative or Defective', Radin (2005) asserts that many academics explain the belief in the paranormal by using one of the three following hypotheses: Ignorance, deprivation, or deficiency. 'The ignorance hypothesis asserts that people believe in the paranormal because they're uneducated or stupid. The deprivation hypothesis proposes that these beliefs exist to provide a way to cope in the face of psychological uncertainties and physical stressors. The deficiency hypothesis asserts that such beliefs arise because people are mentally defective in some way, ranging from low intelligence or poor critical thinking ability to a full-blown psychosis (Radin). The deficiency hypothesis gets some support from the fact that the belief in the paranormal is an aspect of a schizotypical personality (Pizzagalli, Lehman, and Brugger, 2001).

A psychological study involving 174 members of the Society for Psychical Research completed a delusional ideation questionnaire and a deductive reasoning task. As predicted, the study showed that "individuals who reported a strong belief in the paranormal made more errors and displayed more delusional ideation than skeptical individuals". There was also a reasoning bias, which was limited to people who reported a belief in, rather than experience of, paranormal phenomena. The results suggested that reasoning abnormalities may have a causal role in the formation of paranormal beliefs.

Research has shown that people reporting contact with aliens have higher levels of absorption, dissociativity, fantasy proneness and tendency to hallucinate.

Findings have shown in specific cases that paranormal belief acts as a psychodynamic coping function and serves as a mechanism for coping with stress. Survivors from childhood sexual abuse, violent and unsettled home environments have reported having higher levels of paranormal belief. A study of a random sample of 502 adults revealed paranormal experiences were common in the population which were linked to a history of childhood trauma and dissociative symptoms. Research has also suggested that people who perceive themselves as having little control over their lives may develop paranormal beliefs to help provide an enhanced sense of control. The similarities between paranormal events and descriptions of trauma have also been noted.

Gender differences in surveys on paranormal belief have reported women scoring higher than men overall and men having greater belief in UFOs and extraterrestrials. Surveys have also investigated the relationship between ethnicity and paranormal belief. In a sample of American university students (Tobacyk et al. 1988) it was found that people of African descent have a higher level of belief in superstitions and witchcraft while belief in extraterrestrial life forms was stronger among people of European descent. Otis and Kuo (1984) surveyed Singapore university students and found Chinese, Indian and Malay students to differ in their paranormal beliefs, with the Chinese students showing greater skepticism.

According to American surveys analysed by Bader et al (2011) African Americans have the firmest belief in the paranormal, and while the findings are not uniform, the "general trend is for whites to show lesser belief in most paranormal subjects". Polls show that about fifty percent of the United States population believes in the paranormal. Robert L. Park says a lot of people believe in it because they "want it to be so".

A 2013 study that utilized a biological motion perception task discovered a "relation between illusory pattern perception and supernatural and paranormal beliefs and suggest that paranormal beliefs are strongly related to agency detection biases".

A 2014 study discovered that schizophrenic patients have more belief in psi than healthy adults.

Neuroscience

Some scientists have investigated possible neurocognitive processes underlying the formation of paranormal beliefs. In a study (Pizzagalli et al, 2000), data demonstrated that "subjects differing in their declared belief in and experience with paranormal phenomena as well as in their schizotypal ideation, as determined by a standardized instrument, displayed differential brain electric activity during resting periods." Another study (Schulter and Papousek, 2008) wrote that paranormal belief can be explained by patterns of functional hemispheric asymmetry that may be related to perturbations during fetal development.

It was also realized that people with higher dopamine levels have the ability to find patterns and meanings where there are none. This is why scientists have connected high dopamine levels with paranormal belief.

Criticism

Some scientists have criticized the media for promoting paranormal claims. In a report by Singer and Benassi in 1981, they wrote that the media may account for much of the near universality of paranormal belief, as the public is constantly exposed to films, newspapers, documentaries, and books endorsing paranormal claims, while critical coverage is largely absent. According to Paul Kurtz, "Regarding the many talk shows that constantly deal with paranormal topics, the skeptical viewpoint is rarely heard; and when it is permitted to be expressed, it is usually sandbagged by the host or other guests." Kurtz described the popularity of public belief in the paranormal as a "quasi-religious phenomenon", a manifestation of a transcendental temptation, a tendency for people to seek a transcendental reality that cannot be known by using the methods of science. Kurtz compared this to a primitive form of magical thinking.

Terence Hines has written that on a personal level, paranormal claims could be considered a form of consumer fraud as people are "being induced through false claims to spend their money—often large sums—on paranormal claims that do not deliver what they promise" and uncritical acceptance of paranormal belief systems can be damaging to society.

Belief polls

While the existence of paranormal phenomena is controversial and debated passionately by both proponents of the paranormal and by skeptics, surveys are useful in determining the beliefs of people regarding paranormal phenomena. These opinions, while not constituting scientific evidence for or against, may give an indication of the mindset of a certain portion of the population (at least among those who answered the polls). The number of people worldwide who believe in parapsychological powers has been estimated to be 3 to 4 billion.

A survey conducted in 2006 by researchers from Australia's Monash University sought to determine the types of phenomena that people claim to have experienced and the effects these experiences have had on their lives. The study was conducted as an online survey with over 2,000 respondents from around the world participating. The results revealed that around 70% of the respondents believe they have had an unexplained paranormal event that changed their life, mostly in a positive way. About 70% also claimed to have seen, heard, or been touched by an animal or person that they knew was not there; 80% have reported having a premonition, and almost 50% stated they recalled a previous life.

Polls were conducted by Bryan Farha at Oklahoma City University and Gary Steward of the University of Central Oklahoma in 2006. They found fairly consistent results compared to the results of a Gallup poll in 2001.

Percentage of U.S. citizens polled
Phenomena Farha-Steward (2006) Gallup (2001) Gallup (2005)
Belief Unsure Disbelief Belief Unsure Disbelief Belief Unsure Disbelief
Psychic, Spiritual healing 57 26 18 54 19 26 55 17 26
ESP 29 39 33 50 20 27 41 25 32
Haunted houses 41 25 35 42 16 41 37 16 46
Demonic possession 41 28 32 41 16 41 42 13 44
Ghosts 40 27 34 38 17 44 32 19 48
Telepathy 25 34 42 36 26 35 31 27 42
Extraterrestrials visited Earth in the past 18 34 49 33 27 38 24 24 51
Clairvoyance and Prophecy 24 33 43 32 23 45 26 24 50
Mediumship 16 29 55 28 26 46 21 23 55
Astrology 17 26 57 28 18 52 25 19 55
Witches 27 19 55 26 15 59 21 12 66
Reincarnation 16 28 57 25 20 54 20 20 59

A survey by Jeffrey S. Levin, associate professor at Eastern Virginia Medical School, found that more than two-thirds of the United States population reported having at least one mystical experience. A 1996 Gallup poll estimated that 71% of the people in the U.S. believed that the government was covering up information about UFOs. A 2002 Roper poll conducted for the Sci Fi channel reported that 56% thought UFOs were real craft and 48% that aliens had visited the Earth.

A 2001 National Science Foundation survey found that 9% of people polled thought astrology was very scientific, and 31% thought it was somewhat scientific. About 32% of Americans surveyed stated that some numbers were lucky, while 46% of Europeans agreed with that claim. About 60% of all people polled believed in some form of Extra-sensory perception, and 30% thought that "some of the unidentified flying objects that have been reported are really space vehicles from other civilizations."

In 2017, the Chapman University Survey of American Fears asked about seven paranormal beliefs and found that "the most common belief is that ancient advanced civilizations such as Atlantis once existed (55%). Next was that places can be haunted by spirits (52%), aliens have visited Earth in our ancient past (35%), aliens have come to Earth in modern times (26%), some people can move objects with their minds (25%), fortune tellers and psychics can survey the future (19%), and Bigfoot is a real creature. Only one-fourth of respondents didn't hold at least one of these beliefs."

Paranormal challenges

In 1922, Scientific American offered two US$2,500 offers: (1) for the first authentic spirit photograph made under test conditions, and (2) for the first psychic to produce a "visible psychic manifestation". Harry Houdini was a member of the investigating committee. The first medium to be tested was George Valiantine, who claimed that in his presence spirits would speak through a trumpet that floated around a darkened room. For the test, Valiantine was placed in a room, the lights were extinguished, but unbeknownst to him, his chair had been rigged to light a signal in an adjoining room if he ever left his seat. Because the light signals were tripped during his performance, Valiantine did not collect the award. The last to be examined by Scientific American was Mina Crandon in 1924.

Since then, many individuals and groups have offered similar monetary awards for proof of the paranormal in an observed setting. These prizes have a combined value of over $2.4 million.

The James Randi Educational Foundation offered a prize of a million dollars to a person who could prove that they had supernatural or paranormal abilities under appropriate test conditions. Several other skeptic groups also offer a monetary prize for proof of the paranormal, including the largest group of paranormal investigators, the Independent Investigations Group, which has chapters in Hollywood, Atlanta, Denver, Washington, D.C., Alberta, B.C., and San Francisco. The IIG offers a $100,000 prize and a $5,000 finders fee if a claimant can prove a paranormal claim under 2 scientifically controlled tests. Founded in 2000, no claimant has passed the first (and lower odds) of the test.

Behavioral epigenetics

From Wikipedia, the free encyclopedia

Behavioral epigenetics is the field of study examining the role of epigenetics in shaping animal and human behavior. It seeks to explain how nurture shapes nature, where nature refers to biological heredity and nurture refers to virtually everything that occurs during the life-span (e.g., social-experience, diet and nutrition, and exposure to toxins). Behavioral epigenetics attempts to provide a framework for understanding how the expression of genes is influenced by experiences and the environment to produce individual differences in behaviourcognitionpersonality, and mental health.

Epigenetic gene regulation involves changes other than to the sequence of DNA and includes changes to histones (proteins around which DNA is wrapped) and DNA methylation. These epigenetic changes can influence the growth of neurons in the developing brain as well as modify the activity of neurons in the adult brain. Together, these epigenetic changes in neuron structure and function are thought to have an influence on behavior.

Background

In biology, and specifically genetics, epigenetics is the study of heritable changes in gene activity which are not caused by changes in the DNA sequence; the term can also be used to describe the study of stable, long-term alterations in the transcriptional potential of a cell that are not necessarily heritable. Genetic activity can be influenced by environmental factors, as well as parenting styles, diet and even social interactions.

Examples of mechanisms that produce such changes are DNA methylation and histone modification, both alter how genes are expressed without changing the underlying DNA sequence and both are also essential for learning and memory. Gene expression can be controlled through the action of repressor proteins that attach to silencer regions of the DNA.

Modifications of the epigenome do not alter DNA.

DNA methylation turns a gene "off" – it results in the inability of genetic information to be read from DNA; removing the methyl tag can turn the gene back "on".

Histone modification changes the way that DNA is packaged into chromosomes. These changes impact how genes are expressed.

Epigenetic changes occur not only in the developing fetus, but also in individuals throughout the human life-span.

Discovery

The first documented example of epigenetics affecting behavior was provided by Michael Meaney and Moshe Szyf. While working at McGill University in Montréal in 2004, they discovered that the type and amount of nurturing a mother rat provides in the early weeks of the rat's infancy determines how that rat responds to stress later in life. This stress sensitivity was linked to a down-regulation in the expression of the glucocorticoid receptor in the brain. In turn, this down-regulation was found to be a consequence of the extent of methylation in the promoter region of the glucocorticoid receptor gene. Immediately after birth, Meaney and Szyf found that methyl groups repress the glucocorticoid receptor gene in all rat pups, making the gene unable to unwind from the histone in order to be transcribed, causing a decreased stress response. Nurturing behaviours from the mother rat were found to stimulate activation of stress signalling pathways that remove methyl groups from DNA. This releases the tightly wound gene, exposing it for transcription. The glucocorticoid gene is activated, resulting in lowered stress response. Rat pups that receive a less nurturing upbringing are more sensitive to stress throughout their life-span.

This pioneering work in rodents has been difficult to replicate in humans because of a general lack of availability of human brain tissue for measurement of epigenetic changes.

Cognition

Learning and memory

A 2010 review discussed the role of DNA methylation in memory formation and storage, but the precise mechanisms involving neuronal function, memory, and methylation reversal remained unclear at the time.

Further research investigated the molecular basis for long-term memory. By 2015 it had become clear that long-term memory requires gene transcription activation and de novo protein synthesis. Long-term memory formation depends on both the activation of memory promoting genes and the inhibition of memory suppressor genes, and DNA methylation/DNA demethylation was found to be a major mechanism for achieving this dual regulation.

Rats with a new, strong long-term memory due to contextual fear conditioning have reduced expression of about 1,000 genes and increased expression of about 500 genes in the hippocampus of the brain 24 hours after training, thus exhibiting modified expression of 9.17% of the rat hippocampal genome. Reduced gene expressions were associated with methylations of those genes and hypomethylation was found for genes involved in synaptic transmission and neuronal differentiation.

Further research into long-term memory has shed light on the molecular mechanisms by which methylation is created or removed, as reviewed in 2022. These mechanisms include, for instance, signal-responsive TOP2B-induced double-strand breaks in immediate early genes. More than 100 DNA double-strand breaks occur, both in the hippocampus and in the medial prefrontal cortex (mPFC), in two peaks, at 10 minutes and at 30 minutes after contextual fear conditioning. This appears to be earlier than the DNA methylations and demethylations of neuron DNA in the hippocampus that were measured at one hour and 24 hours after contextual fear conditioning.

The double strand breaks occur at known memory-related immediate early genes (among other genes) in neurons after neuron activation. These double-strand breaks allow the genes to be transcribed and then translated into active proteins.

One immediate early gene newly transcribed after a double-strand break is EGR1. EGR1 is an important transcription factor in memory formation. It has an essential role in brain neuron epigenetic reprogramming. EGR1 recruits the TET1 protein that initiates a pathway of DNA demethylation. Removing DNA methylation marks allows the activation of downstream genes (see Regulation of gene expression#Regulation of transcription in learning and memory. EGR1 brings TET1 to promoter sites of genes that need to be demethylated and activated (transcribed) during memory formation. EGR-1, together with TET1, is employed in programming the distribution of DNA demethylation sites on brain DNA during memory formation and in long-term neuronal plasticity.

DNMT3A2 is another immediate early gene whose expression in neurons can be induced by sustained synaptic activity. DNMTs bind to DNA and methylate cytosines at particular locations in the genome. If this methylation is prevented by DNMT inhibitors, then memories do not form. If DNMT3A2 is over-expressed in the hippocampus of young adult mice it converts a weak learning experience into long-term memory and also enhances fear memory formation.

In another mechanism reviewed in 2022, the messenger RNAs of many genes that had been subjected to methylation-controlled increases or decreases are transported by neural granules (messenger RNPs) to the dendritic spines. At these locations the messenger RNAs can be translated into the proteins that control signaling at neuronal synapses.

Studies in rodents have found that the environment exerts an influence on epigenetic changes related to cognition, in terms of learning and memory; environmental enrichment correlated with increased histone acetylation, and verification by administering histone deacetylase inhibitors induced sprouting of dendrites, an increased number of synapses, and reinstated learning behaviour and access to long-term memories. Research has also linked learning and long-term memory formation to reversible epigenetic changes in the hippocampus and cortex in animals with normal-functioning, non-damaged brains. In human studies, post-mortem brains from patients with Alzheimer's dementia show high levels of histone de-acetylase.

Psychopathology and mental health

Anxiety and risk-taking

Monozygotic twins are identical twins. Twin studies help to reveal epigenetic differences related to various aspects of psychology.

Due to the stress that can be placed on individuals can increase levels of anxiety and the way the epigenetics are responding in relation to the individual. Epigenetics investigate how alterations upon environment and behavior can affect the way in which genes operate. Within research, it's know that majority of epigenetic modifications identified have been involved with anxiety-like phenotypes that involve genes that regulate the hypothalamic-pituitary adrenal axis which results to the way our bodies respond to stress that we endure as people. Epigenetics is altered by many influences, whether it be genetic and or environmental. Within the prenatal times it is evident that through changes of DNA methylation, that maternal and pre-maternal distress have been connected to modifications in the fetal HPA axis. This demonstrates that the link between our development, stress and anxiety a mother can feel during this time creates a linkage in the response of how the epigenetic may be altered in the response of the HPA axis. Linkage of the impacts of childhood trauma in connection with epigenetic and anxiety, in that there is a change in DNA methylation process, increasing the chances of neuroendocrine damage to likely occur. In relation, the neuroendocrine damage induces the state of depression, making it mentally unstable for a person to possibly perform their daily activities. The Brain-derived neurotropic factor (BDNF) is known to change its state because of epigenetic mechanisms and contributes to the alters within the development process necessary for the brain of us individuals. Alterations within the epigenetic process can be treated using different types clinical procedures, by targeting specific changes and the treating them with the proper sort of care.

Stress

The hypothalamic pituitary adrenal axis is involved in the human stress response.

Animal and human studies have found correlations between poor care during infancy and epigenetic changes that correlate with long-term impairments that result from neglect.

Studies in rats have shown correlations between maternal care in terms of the parental licking of offspring and epigenetic changes. A high level of licking results in a long-term reduction in stress response as measured behaviorally and biochemically in elements of the hypothalamic-pituitary-adrenal axis (HPA). Further, decreased DNA methylation of the glucocorticoid receptor gene were found in offspring that experienced a high level of licking; the glucorticoid receptor plays a key role in regulating the HPA. The opposite is found in offspring that experienced low levels of licking, and when pups are switched, the epigenetic changes are reversed. This research provides evidence for an underlying epigenetic mechanism. Further support comes from experiments with the same setup, using drugs that can increase or decrease methylation. Finally, epigenetic variations in parental care can be passed down from one generation to the next, from mother to female offspring. Female offspring who received increased parental care (i.e., high licking) became mothers who engaged in high licking and offspring who received less licking became mothers who engaged in less licking.

In humans, a small clinical research study showed the relationship between prenatal exposure to maternal mood and genetic expression resulting in increased reactivity to stress in offspring. Three groups of infants were examined: those born to mothers medicated for depression with serotonin reuptake inhibitors; those born to depressed mothers not being treated for depression; and those born to non-depressed mothers. Prenatal exposure to depressed/anxious mood was associated with increased DNA methylation at the glucocorticoid receptor gene and to increased HPA axis stress reactivity. The findings were independent of whether the mothers were being pharmaceutically treated for depression.

Drug addiction


Signaling cascade in the nucleus accumbens that results in psychostimulant addiction
The image above contains clickable links
This diagram depicts the signaling events in the brain's reward center that are induced by chronic high-dose exposure to psychostimulants that increase the concentration of synaptic dopamine, like amphetamine, methamphetamine, and phenethylamine. Following presynaptic dopamine and glutamate co-release by such psychostimulants, postsynaptic receptors for these neurotransmitters trigger internal signaling events through a cAMP-dependent pathway and a calcium-dependent pathway that ultimately result in increased CREB phosphorylation. Phosphorylated CREB increases levels of ΔFosB, which in turn represses the c-Fos gene with the help of corepressorsc-Fos repression acts as a molecular switch that enables the accumulation of ΔFosB in the neuron. A highly stable (phosphorylated) form of ΔFosB, one that persists in neurons for 1–2 months, slowly accumulates following repeated high-dose exposure to stimulants through this process. ΔFosB functions as "one of the master control proteins" that produces addiction-related structural changes in the brain, and upon sufficient accumulation, with the help of its downstream targets (e.g., nuclear factor kappa B), it induces an addictive state.

Environmental and epigenetic influences seem to work together to increase the risk of addiction. For example, environmental stress has been shown to increase the risk of substance abuse. In an attempt to cope with stress, alcohol and drugs can be used as an escape. Once substance abuse commences, however, epigenetic alterations may further exacerbate the biological and behavioural changes associated with addiction.

Even short-term substance abuse can produce long-lasting epigenetic changes in the brain of rodents, via DNA methylation and histone modification. Epigenetic modifications have been observed in studies on rodents involving ethanol, nicotine, cocaine, amphetamine, methamphetamine and opiates. Specifically, these epigenetic changes modify gene expression, which in turn increases the vulnerability of an individual to engage in repeated substance overdose in the future. In turn, increased substance abuse results in even greater epigenetic changes in various components of a rodent's reward system (e.g., in the nucleus accumbens). Hence, a cycle emerges whereby changes in areas of the reward system contribute to the long-lasting neural and behavioural changes associated with the increased likelihood of addiction, the maintenance of addiction and relapse. In humans, alcohol consumption has been shown to produce epigenetic changes that contribute to the increased craving of alcohol. As such, epigenetic modifications may play a part in the progression from the controlled intake to the loss of control of alcohol consumption. These alterations may be long-term, as is evidenced in smokers who still possess nicotine-related epigenetic changes ten years after cessation. Therefore, epigenetic modifications may account for some of the behavioural changes generally associated with addiction. These include: repetitive habits that increase the risk of disease, and personal and social problems; need for immediate gratification; high rates of relapse following treatment; and, the feeling of loss of control.

Evidence for relevant epigenetic changes came from human studies involving alcohol,[61] nicotine, and opiate abuse. Evidence for epigenetic changes stemming from amphetamine and cocaine abuse derives from animal studies. In animals, drug-related epigenetic changes in fathers have also been shown to negatively affect offspring in terms of poorer spatial working memory, decreased attention and decreased cerebral volume.[62]

Eating disorders and obesity

Epigenetic changes may help to facilitate the development and maintenance of eating disorders via influences in the early environment and throughout the life-span. Pre-natal epigenetic changes due to maternal stress, behaviour and diet may later predispose offspring to persistent, increased anxiety and anxiety disorders. These anxiety issues can precipitate the onset of eating disorders and obesity, and persist even after recovery from the eating disorders.

Epigenetic differences accumulating over the life-span may account for the incongruent differences in eating disorders observed in monozygotic twins. At puberty, sex hormones may exert epigenetic changes (via DNA methylation) on gene expression, thus accounting for higher rates of eating disorders in men as compared to women. Overall, epigenetics contribute to persistent, unregulated self-control behaviours related to the urge to binge.

Schizophrenia

Epigenetic changes including hypomethylation of glutamatergic genes (i.e., NMDA-receptor-subunit gene NR3B and the promoter of the AMPA-receptor-subunit gene GRIA2) in the post-mortem brains of people with schizophrenia are associated with increased levels of the neurotransmitter glutamate. Since glutamate is the most prevalent, fast, excitatory neurotransmitter, increased levels may result in the psychotic episodes related to schizophrenia. Epigenetic changes affecting a greater number of genes have been detected in men with schizophrenia as compared to women with the illness.

Population studies have established a strong association linking schizophrenia in children born to older fathers. Specifically, children born to fathers over the age of 35 years are up to three times more likely to develop schizophrenia. Epigenetic dysfunction in human male sperm cells, affecting numerous genes, have been shown to increase with age. This provides a possible explanation for increased rates of the disease in men. To this end, toxins (e.g., air pollutants) have been shown to increase epigenetic differentiation. Animals exposed to ambient air from steel mills and highways show drastic epigenetic changes that persist after removal from the exposure. Therefore, similar epigenetic changes in older human fathers are likely. Schizophrenia studies provide evidence that the nature versus nurture debate in the field of psychopathology should be re-evaluated to accommodate the concept that genes and the environment work in tandem. As such, many other environmental factors (e.g., nutritional deficiencies and cannabis use) have been proposed to increase the susceptibility of psychotic disorders like schizophrenia via epigenetics.

Bipolar disorder

Evidence for epigenetic modifications for bipolar disorder is unclear. One study found hypomethylation of a gene promoter of a prefrontal lobe enzyme (i.e., membrane-bound catechol-O-methyl transferase, or COMT) in post-mortem brain samples from individuals with bipolar disorder. COMT is an enzyme that metabolizes dopamine in the synapse. These findings suggest that the hypomethylation of the promoter results in over-expression of the enzyme. In turn, this results in increased degradation of dopamine levels in the brain. These findings provide evidence that epigenetic modification in the prefrontal lobe is a risk factor for bipolar disorder. However, a second study found no epigenetic differences in post-mortem brains from bipolar individuals.

Major depressive disorder

The causes of major depressive disorder (MDD) are poorly understood from a neuroscience perspective. The epigenetic changes leading to changes in glucocorticoid receptor expression and its effect on the HPA stress system discussed above, have also been applied to attempts to understand MDD.

Much of the work in animal models has focused on the indirect downregulation of brain derived neurotrophic factor (BDNF) by over-activation of the stress axis. Studies in various rodent models of depression, often involving induction of stress, have found direct epigenetic modulation of BDNF as well.

Psychopathy

Epigenetics may be relevant to aspects of psychopathic behaviour through methylation and histone modification. These processes are heritable but can also be influenced by environmental factors such as smoking and abuse. Epigenetics may be one of the mechanisms through which the environment can impact the expression of the genome. Studies have also linked methylation of genes associated with nicotine and alcohol dependence in women, ADHD, and drug abuse. It is probable that epigenetic regulation as well as methylation profiling will play an increasingly important role in the study of the play between the environment and genetics of psychopaths.

Social insects

Several studies have indicated DNA cytosine methylation linked to the social behavior of insects, such as honeybees and ants. In honeybees, when nurse bee switched from her in-hive tasks to out foraging, cytosine methylation marks are changing. When a forager bee was reversed to do nurse duties, the cytosine methylation marks were also reversed. Knocking down the DNMT3 in the larvae changed the worker to queen-like phenotype. Queen and worker are two distinguish castes with different morphology, behavior, and physiology. Studies in DNMT3 silencing also indicated DNA methylation may regulate gene alternative splicing and pre-mRNA maturation.

Limitations and future direction

Many researchers contribute information to the Human Epigenome Consortium. The aim of future research is to reprogram epigenetic changes to help with addiction, mental illness, age related changes, memory decline, and other issues. However, the sheer volume of consortium-based data makes analysis difficult. Most studies also focus on one gene. In actuality, many genes and interactions between them likely contribute to individual differences in personality, behaviour and health. As social scientists often work with many variables, determining the number of affected genes also poses methodological challenges. More collaboration between medical researchers, geneticists and social scientists has been advocated to increase knowledge in this field of study.

Limited access to human brain tissue poses a challenge to conducting human research. Not yet knowing if epigenetic changes in the blood and (non-brain) tissues parallel modifications in the brain, places even greater reliance on brain research. Although some epigenetic studies have translated findings from animals to humans, some researchers caution about the extrapolation of animal studies to humans. One view notes that when animal studies do not consider how the subcellular and cellular components, organs and the entire individual interact with the influences of the environment, results are too reductive to explain behaviour.

Some researchers note that epigenetic perspectives will likely be incorporated into pharmacological treatments. Others caution that more research is necessary as drugs are known to modify the activity of multiple genes and may, therefore, cause serious side effects. However, the ultimate goal is to find patterns of epigenetic changes that can be targeted to treat mental illness, and reverse the effects of childhood stressors, for example. If such treatable patterns eventually become well-established, the inability to access brains in living humans to identify them poses an obstacle to pharmacological treatment. Future research may also focus on epigenetic changes that mediate the impact of psychotherapy on personality and behaviour.

Most epigenetic research is correlational; it merely establishes associations. More experimental research is necessary to help establish causation. Lack of resources has also limited the number of intergenerational studies. Therefore, advancing longitudinal and multigenerational, experience-dependent studies will be critical to further understanding the role of epigenetics in psychology.

Disability

From Wikipedia, the free encyclopedia

Disability culture is a concept developed in the late 1980s to describe a unique lifestyle shaped or influenced by disability, distinct from pathologizing discourses (i.e., concepts about disability that are derived from eugenics or the medical model). Some disabled people have mobilized this concept in order to reframe disability as an identity or as a cultural minority experience. As described by disability historian, Dr. Steven E. Brown, disability culture is “a set of artifacts, beliefs, [and] expressions created by disabled people ourselves to describe our own life experiences. It is not primarily how we are treated, but what we have created."

Deaf culture has an older history, having been described in 1965, and Deaf culture can be connected to the larger disability culture, both due to deafness being viewed by others as a disability, and many deaf people being both Deaf and disabled in other ways, which is known as being Deaf plus.

Disability culture cannot be defined by one specific description or language. It is a complex blending of art, performance, expression, and community. Within this culture, the word "disabled" has been re-purposed to represent a social identity of empowerment and awareness. Like many civil rights movements in the past, disability culture challenges the norms of society, and seeks to counter oppressive entities such as medicalization and institutionalization. Its core values as a culture are reflected in art, conversation, goals, or behaviors. These core values often include: "an acceptance of human differences, an acceptance of human vulnerability and interdependence, a tolerance for a lack of resolution of the unpredictable in life, and a humor to laugh at the oppressor or situation, however dire it may be".

"The elements of our culture include, certainly, our longstanding social oppression, but also our emerging art and humor, our piecing together of our history, our evolving language and symbols, our remarkably unified world view, beliefs and values, and our strategies for surviving and thriving." -Carol Gill Ph.D.

Disability culture is a trajectory, a movement, a path, rather than a destination: "Disability culture is the difference between being alone, isolated, and individuated with a physical, cognitive, emotional or sensory difference that in our society invites discrimination and reinforces that isolation – the difference between all that and being in community. Naming oneself part of a larger group, a social movement or a subject position in modernity can help to focus energy, and to understand that solidarity can be found – precariously, in improvisation, always on the verge of collapse." - Petra Kuppers

"Disability Culture is the contributions, perspectives and art that comes from our different minds and bodies. Disability culture is the music, words and worldviews that come from the oppression that we face, that come from the exclusion that we face, that come from the erasure that we face. And it is rooted in problem solving. It is rooted in creative thinking. It is rooted in navigating the world differently. It is unapologetic; it is adaptable; it is innovative; and it is resilient. And it deserves to be celebrated." - Lachi

"Disability culture, which values interdependence over the illusion of independence, privileges not a uniform perspective but the validity and value of a wide range of ways of moving through the world - and the varied perspectives those different experiences engender."

Disability rights movement

From Wikipedia, the free encyclopedia
Protestors at a disability rights protest

The disability rights movement is a global social movement, which seeks to secure equal opportunities and equal rights for all disabled people. It is made up of organizations of disability activists, also known as disability advocates, around the world working together with similar goals and demands, such as accessibility and safety in architecture, transportation, and the physical environment; equal opportunities in independent living, employment equity, education, and housing; and freedom from discrimination, abuse, neglect, and from other rights violations.

Disability activists are working to break institutional, physical, and societal barriers that prevent people with disabilities from living their lives like other citizens. Disability rights is complex because there are multiple ways in which a disabled person can have their rights violated in different socio-political, cultural, and legal contexts. For example, a common barrier that disabled individuals face is employment. Specifically, employers are often unwilling or unable to provide the necessary accommodations to enable disabled individuals to effectively carry out their job functions.

History

United States

American disability rights have evolved significantly over the past century. Before the disability rights movement, President Franklin D. Roosevelt's refusal to be publicized using his wheelchair demonstrated and symbolized the existing stigma surrounding disabilities. While campaigning, giving speeches, or acting as a public figure, he hid his disability. This perpetuated the ideology that "disability equates to weakness".

Disability in the United States was viewed as a personal issue, and not many political or governmental organizations existed to support individuals in these groups. In the 1950s, there was a transition to volunteerism and parent-oriented organizations, such as the March of Dimes. While this was the beginning of activism and seeking support for these groups, disabled children were largely hidden by their parents out of fear of forced rehabilitation.

When the civil rights movement took off in the 1960s, disability advocates joined it and the women's rights movements to promote equal treatment and challenge stereotypes. It was at this time that disability rights advocacy began to have a cross-disability focus. People with different kinds of disabilities (physical and mental disabilities, along with visual and hearing disabilities) and different essential needs came together to fight for a common cause. It was not until 1990 that the Americans with Disabilities Act (ADA) was passed, legally prohibiting discrimination on account of disability, and mandating disability access in all buildings and public areas. The ADA is historically significant in that it defined the meaning of reasonable accommodation in order to protect employees and employers.

United Nations

On a global scale, the United Nations has established the Convention on the Rights of Persons with Disabilities, specifically discussing indigenous people with disabilities (Lockwood 146).

Issues

People with intellectual and developmental disabilities

People with intellectual and developmental disabilities focus their efforts on ensuring that they have the same human rights as other people and that they are treated like human beings. Since the formation of the self advocacy movement in the 1960s, the largest focus of the movement has been to get people with I/DD out of institutions and into the community. Another main focus is ensuring that people with intellectual and developmental disabilities are in integrated workplaces that pay at least minimum wage. In the US, it is still legal to pay people with I/DD below minimum wage in sheltered workshops. Many people with intellectual and developmental disabilities are put under guardianship and are not allowed to make their own decisions about their lives.

Another issue is the continued dehumanization of people with intellectual and developmental disabilities, which prompted the slogan People First, still used as a rallying cry and a common organizational name in the self advocacy movement. Self advocates are also involved in the "R-Word" Campaign, in which they try to eliminate the use of the slur "retard". Self advocates successfully advocated to change the name of the Arc.

Autism rights movement

The autism rights movement is a social movement that emphasizes the concept of neurodiversity, viewing the autism spectrum as a result of natural variations in the human brain rather than a disorder to be cured. The autism rights movement advocates for several goals, including greater acceptance of autistic behaviors; therapies that focus on coping skills rather than imitating the behaviors of neurotypical peers; the creation of social networks and events that allow autistic people to socialize on their own terms; and the recognition of the autistic community as a minority group.

Autism rights or neurodiversity advocates believe that the autism spectrum is primarily genetic and should be accepted as a natural expression of the human genome. This perspective is distinct from two other views: the medical perspective that autism is caused by a genetic defect and should be addressed by targeting the autism gene(s), and fringe theories that autism is caused by environmental factors such as vaccines. The movement is controversial. A common criticism against autistic activists is that the majority of them are "high-functioning" or have Asperger syndrome and do not represent the views of "low-functioning" autistic people.

People with mental health issues

Advocates for the rights of people with mental health disabilities focus mainly on self-determination, and an individual's ability to live independently. The right to have an independent life, using paid assistant care instead of being institutionalized, if the individual wishes, is a major goal of the disability rights movement, and is the main goal of the similar independent living and self-advocacy movements, which are most strongly associated with people with intellectual disabilities and mental health disorders. These movements have supported people with disabilities to live as more active participants in society.

Freedom from discrimination and abuse

Freedom from abuse, neglect, and violations of a person's rights are also important goals of the disability rights movement. Abuse and neglect includes inappropriate seclusion and restraint, inappropriate use of force by staff and/or providers, threats, harassment and/or retaliation by staff or providers, failure to provide adequate nutrition, clothing, and/or medical and mental health care, and/or failure to provide a clean and safe living environment, as well as other issues which pose a serious threat to the physical and psychological well-being of a person with a disability. Violations of patients' rights include failure to obtain informed consent for treatment, failure to maintain the confidentiality of treatment records, and inappropriate restriction of the right to communicate and associate with others, as well as other restrictions of rights.[citation needed] As a result of the work done through the disability rights movement, significant disability rights legislation was passed in the 1970s through the 1990s in the U.S.

Major events

Australia

In 1978, protests outside Australia's Parliament House in Canberra helped force the government to rescind taxes on government payments to people with disabilities. Demonstrations inside and outside parliament have been held regarding various issues, leading to an expansion of the National Attendant Care Scheme in 1992 and helping to convince the federal government to establish the Royal Commission into Violence, Abuse, Neglect and Exploitation of People with Disability in 2019. Similar protests outside state parliaments have fed into campaigns for improved rights and funding, leading to improvements in supported accommodation in New South Wales in 1994 and continued support for Queensland disability advocacy services in 2021.

Beginning in 1981, the International Year of the Disabled Person, campaigners targeted beauty pageants such as the Miss Australia Quest in order to, in the words of activist Leslie Hall, "challenge the notion of beauty" and "reject the charity ethic." High-profile demonstrations led to some charities abandoning their use of such contests for fundraising and also saw some remove offensive language from their organisational titles. Following a long nationwide campaign involving hundreds of thousands of people, the National Disability Insurance Scheme was introduced in Australia in 2013 to fund several supports. National campaigns by groups such as Every Australian Counts have since been launched to extend the scheme and protect it from cuts and restrictions on access.

Canada

Canada's largest province, Ontario, created legislation, Accessibility for Ontarians with Disabilities Act, 2005, with the goals of becoming accessible by 2025. In 2019, the Accessible Canada Act became law. This is the first national Canadian legislation on accessibility that affects all government departments and federally regulated agencies.

India

The Rights of Persons with Disabilities Act, 2016 is the disability legislation passed by the Indian Parliament to fulfill its obligation to the United Nations Convention on the Rights of Persons with Disabilities, which India ratified in 2007. The Act replaced the existing Persons With Disabilities (Equal Opportunities, Protection of Rights and Full Participation) Act, 1995. It came into effect on 28 December 2016. This law recognizes 21 disabilities.

United Kingdom

Disability rights activist outside Scottish Parliament, 30 March 2013

In the United Kingdom, following extensive activism by people with disabilities over several decades, the Disability Discrimination Act 1995 (DDA 1995) was passed. This made it unlawful in the United Kingdom to discriminate against people with disabilities in relation to employment, the provision of goods and services, education, and transport. The Equality and Human Rights Commission provides support for this Act. Equivalent legislation exists in Northern Ireland, which is enforced by the Northern Ireland Equality Commission.

Following the introduction of the Bedroom Tax (officially the Under-occupancy penalty) in the Welfare Reform Act 2012, disability activists have played a significant role in the development of Bedroom Tax protests. A wide range of benefit changes are estimated to affect disabled people disproportionately and to compromise disabled people's right to independent living. The Down Syndrome Bill, created by Evan Mitchell OBE, will provide legal recognition to people living with Down syndrome.

United States

In 1948, a watershed for the movement was the proof of the existence of physical and program barriers. The proof was provided as a specification for barrier-free usable facilities for people with disabilities. The specifications provided the minimum requirements for barrier-free physical and program access. An example of barriers is: providing only steps to enter buildings; lack of maintenance of walkways; locations not connected with public transit; lack of visual and hearing communications, which ends up segregating individuals with disabilities from independent participation, and opportunities. The ANSI Barrier Free Standard (phrase coined by Timothy Nugent, the lead investigator) called "ANSI A117.1, Making Buildings Accessible to and Usable by the Physically Handicapped", provides the indisputable proof that the barriers exist. The standard is the outcome of physical therapists, bio-mechanical engineers, and individuals with disabilities who developed and participated in over 40 years of research. The standard provides the criteria for modifying programs and the physical site to provide independence. The standard has been emulated globally since its introduction in Europe, Asia, Japan, Australia, and Canada in the early 1960s.

One of the most important developments of the disability rights movement was the growth of the independent living movement, which emerged in California in the 1960s through the efforts of Edward Roberts and other wheelchair-using individuals. This movement, a subset of the disability rights movement, postulates that people with disabilities are the best experts on their needs, and therefore, they must take the initiative, individually and collectively, in designing and promoting better solutions and must organize themselves for political power. Besides de-professionalization and self-representation, the independent living movement's ideology comprises de-medicalization of disability, de-institutionalization, and cross-disability (i.e., inclusion in the independent living movement regardless of diagnoses). Similarly, the Architectural Barriers Act was passed in 1968, mandating that federally constructed buildings and facilities be accessible to people with physical disabilities. This act is generally considered to be the first-ever federal disability rights legislation. Unfortunately for those with cognitive disabilities, their disability made it more difficult to be the best expert of their own needs, hindering their ability to self-advocate as their wheelchair-using counterparts could. Self-representation was much more difficult for those who could not articulate their thoughts, leading to their dependence on others to carry on the movement.

In 1973, the (American) Rehabilitation Act became law; Sections 501, 503, and 504 prohibited discrimination in federal programs and services and all other programs or services receiving federal funds. Key language in the Rehabilitation Act, found in Section 504, states "No otherwise qualified handicapped [sic] individual in the United States, shall, solely by reason of his [sic] handicap [sic], be excluded from the participation in, be denied the benefits of, or be subjected to discrimination under any program or activity receiving federal financial assistance." The act also specifies money that can be allocated to help disabled people receive training for the work force as well as to assist in making sure that they can then reach work without running into inaccessibility problems. This was the first civil rights law guaranteeing equal opportunity for people with disabilities.

Another crucial turning point was the 504 Sit-in in 1977 of government buildings operated by the United States Department of Health, Education, and Welfare (HEW), conceived by Frank Bowe and organized by the American Coalition of Citizens with Disabilities, that led to the release of regulations pursuant to Section 504 of the Rehabilitation Act of 1973. On April 5, 1977, activists began to demonstrate, and some sat in the offices found in ten of the federal regions, including New York City, Los Angeles, Boston, Denver, Chicago, Philadelphia, and Atlanta. One of the most noteworthy protests occurred in San Francisco. The protesters demanded the signing of regulations for Section 504 of the Rehabilitation Act of 1973. The successful sit-in was led by Judith Heumann. The first day of protests marked the first of a 25-day sit-in. Close to 120 disability activists and protesters occupied the HEW building, and Secretary Joseph Califano finally signed on April 28, 1977. This protest was significant not only because its goal was achieved, but also because it was the foremost concerted effort between people of different disabilities coming together in support of legislation that affected the overall disability population, rather than only specific groups.

In 1978, disability rights activists in Denver, Colorado, organized by the Atlantis Community, held a sit-in and blockade of the Denver Regional Transit Authority buses in 1978. They were protesting the fact that the city's transit system was completely inaccessible for physically disabled people. This action proved to be just the first in a series of civil disobedience demonstrations that lasted for a year until the Denver Transit Authority finally bought buses equipped with wheelchair lifts. In 1983, Americans Disabled for Accessible Public Transit (ADAPT) was responsible for another civil disobedience campaign also in Denver that lasted seven years. They targeted the American Public Transport Association in protest of inaccessible public transportation; this campaign ended in 1990 when bus lifts for people using wheelchairs were required nationwide by the Americans with Disabilities Act.

Another significant protest related to disability rights was the Deaf President Now protest by the Gallaudet University students in Washington, D.C., in March 1988. The eight-day (March 6 – March 13) demonstration, occupation, and lock-out of the school began when the Board of Trustees appointed a new hearing President, Elisabeth Zinser, over two Deaf candidates. The students' primary grievance was that the university, which was dedicated to the education of people who are Deaf, had never had a Deaf president, someone representative of them. Of the protesters' four demands, the main one was the resignation of the current president and the appointment of a Deaf one. The demonstration consisted of about 2,000 students and nonstudent participants. The protests took place on campus, in government buildings, and in the streets. In the end, all the students' demands were met and [[I. King Jordan was appointed the first Deaf President of the university.

In 1990, the Americans with Disabilities Act became law, and it provided comprehensive civil rights protection for people with disabilities. Closely modeled after the Civil Rights Act and Section 504, the law was the most sweeping disability rights legislation in American history. It mandated that local, state, and federal governments and programs be accessible, that employers with more than 15 employees make "reasonable accommodations" for workers with disabilities and not discriminate against otherwise qualified workers with disabilities, and that public accommodations such as restaurants and stores not discriminate against people with disabilities and that they make reasonable modifications to ensure access for disabled members of the public. The act also mandated access to public transportation, communication, and other areas of public life.

The first Disability Pride March in the United States was held in Boston in 1990. A second Disability Pride March was held in Boston in 1991. There were no subsequent Disability Pride Marches/Parades for many years, until Chicago on Sunday, July 18, 2004. It was funded with $10,000 in seed money that Sarah Triano received in 2003 as part of the Paul G. Hearne Leadership award from the American Association of People with Disabilities. According to Triano, 1,500 people attended the parade. Yoshiko Dart was the parade marshal.[41]

Exhibitions and collections

To mark the 10th anniversary of the Americans with Disabilities Act, the Smithsonian Institution National Museum of American History opened an exhibition that examined the history of activism by people with disabilities, their friends, and families to secure the civil rights guaranteed to all Americans. Objects on view included the pen President George H. W. Bush used to sign the Act and one of the first ultralight wheelchairs. The exhibition was designed for maximum accessibility. Web-based kiosks - prototypes for a version that will eventually be available to museums and other cultural institutions - provided alternate formats to experience the exhibition. The exhibition was open from July 6, 2000, to July 23, 2001.

Debates and approaches

A key debate in the disability rights movement is between affirmative action for disabled people versus fighting for equitable treatment. According to a 1992 polling organization, many fear that integrating disabled people into the workplace may affect their company image, or it may result in decreased productivity. This coincides with the 1992 parliamentary review of the Employment Equity Act, which stated that employers should look to implement equity without having an official quota system. This remains an ongoing debate.

An additional debate is between institutionalizing disabled people and supporting them in their homes. In 1963, during John F. Kennedy's presidency, he transformed the national view of mental health by boosting funding for community-based programs and drafting legislation for mental health care. He also created the President's Panel on Mental Retardation, which created recommendations for new programs that governments can implement on a state level, therefore moving away from "custodial institutions". This shift away from institutionalization has generated a long-lasting stigma against mental health institutions, which is why in politics there is often not enough funding for this concept.

According to the US Supreme Court case Humphrey v. Cady, civil commitment laws and eligibility for intervention exist only in the instance when the person is ruled an immediate danger to themself or others. The difficulty of proving "immediate danger" has led to the unexpected outcome that it is harder to commit mentally ill patients to hospital and easier to send them to prison. According to the National Alliance on Mental Illness, about 15% male inmates and 30% female inmates have some kind of serious mental illness that remains untreated.

Another ongoing debate is how to cultivate self-determination for disabled people. The common article 1 of the International Covenant on Civil and Political Rights and the International Covenant on Economic, Social and Cultural Rights asserts that "All peoples have the right to self-determination" with free will. Because this highlights the concept of free and autonomous choice, one argument is that any government interference deters self-determination, thus leaving it to disabled people to seek out any help they need from charities and nonprofit organizations. Charitable organizations, such as churches, believe in helping disabled people with nothing in return. On the other hand, another approach is a participatory, symbiotic relationship, which include methods like professional development and resource provisions. More specifically, one approach is to allow disabled people to self-articulate their needs and generate their own solutions and analyses. Instead of passive participation, which is participation by being told what to do or what has been done, this approach proposes to allow this group to be self-sufficient and make their own decisions. Barriers to this include defining who is a self-sufficient individual with a disability, circling back to the concept of self-determination.

Number theory

From Wikipedia, the free encyclopedia https://en.wikipedia.org/wiki/Number_t...