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Thursday, January 29, 2015

Psychotherapy


From Wikipedia, the free encyclopedia
 
Psychotherapy is the treatment of a patient's mental health problems by talking with a psychiatrist, psychologist, licensed clinical social worker or other mental health provider. During psychotherapy a client learns about their moods, feelings, thoughts and behaviors and how to better respond to life's challenges.

sychotherapy includes interactive processes between a person or group and a qualified mental health professional (psychiatrist, psychologist, clinical social worker, licensed counselor, or other trained practitioner). Its purpose is the exploration of thoughts, feelings and behavior for the purpose of problem solving or achieving higher levels of functioning.[1] Psychotherapy aims to increase the individual's sense of his/her own well-being. Psychotherapists employ a range of techniques based on experiential relationship building, dialogue, communication and behavior change that are designed to improve the mental health of a client or patient, or to improve group relationships (such as in a family).

Psychotherapy may also be performed by practitioners with different qualifications, including psychiatry, psychology, social work (clinical or psychiatric), counseling psychology, mental health counseling, marriage and family therapy, rehabilitation counseling, school counseling, hypnotherapy, play therapy, music therapy, art therapy, drama therapy, dance/movement therapy, occupational therapy, psychiatric nursing, psychoanalysis and those from other psychotherapies. It may be legally regulated, voluntarily regulated or unregulated, depending on the jurisdiction. Requirements of these professions vary, and often require graduate school and supervised clinical experience. Psychotherapy in Europe is increasingly seen as an independent profession, rather than restricted to psychologists and psychiatrists as stipulated in some countries.

Regulation

Continental Europe

In Germany, the Psychotherapy Act (PsychThG, 1998) restricts the practice of psychotherapy for adults to the professions of psychology who have completed a five-year course. Children may receive such therapy from social pedagogues and social workers who have completed a five-year postgraduate course.[2] Physicians must complete a residency in psychotherapeutic medicine till 2003. A training in psychotherapy is also part of residency in psychiatry and psychosomatic medicine the title of those professionals is consultant for psychiatry and psychotherapy and consultant for psychosomatic medicine and psychotherapy. All consultant physicians are able to specialize themselves in psychotherapy for their province e.g. in psychotherapy for oncology in a five-year course.

In Italy, the Ossicini Act (no. 56/1989, art. 3) restricts the practice of psychotherapy to graduates in psychology or medicine who have completed a four-year postgraduate course in psychotherapy at a training school recognised by the state.[n 1]

French legislation restricts use of the title "psychotherapist" to professionals on the National Register of Psychotherapists;[n 2] the inscription on this register requires a training in clinical psychopathology and a period of internship which is only open to physicians or titulars of a master's degree in psychology or psychoanalysis.

Sweden has a similar restriction on the title "psychotherapist", which may only be used by professionals who have gone through a post-graduate training in psychotherapy and then applied for a licence, issued by the National Board of Health and Welfare.[5]

Austria and Switzerland (2011) have laws that recognize multidifunctional-disciplinary approaches.

United Kingdom

In the United Kingdom, psychotherapy is voluntarily regulated. National registers for psychotherapists and counsellors are maintained by three main umbrella bodies:[n 3]
  1. The United Kingdom Council for Psychotherapy (UKCP)
  2. The British Association for Counselling and Psychotherapy (BACP)
  3. The British Psychoanalytic Council (BPC - formerly the British Confederation of Psychotherapists)
There are many smaller professional bodies and associations such as the Association of Child Psychotherapists (ACP)[7] and the British Association of Psychotherapists (BAP).[8]

Following a 2007 United Kingdom Government White Paper, "Trust Assurance and Safety – The Regulation of Health Professionals in the 21st Century"[9] the Health Professions Council (HPC) consulted on potential statutory regulation of psychotherapists and counsellors. The HPC is an official state regulator that regulates some 15 professions at present. Research by academics at King's College London subsequently studied the effects of increasing regulation of psychotherapists and counsellors, compared with the effects of statutory regulation of medical doctors. The research found significant unintended effects of statutory regulation, especially defensive practice,[10] and concluded that mandatory professional regulation was a more effective way of regulating the practices of psychotherapists and counsellors.[11]

Government policy subsequently moved away from statutory regulation, and the Professional Standards Authority for Health and Social Care (PSA) launched an Accredited Voluntary Registers scheme.[12][13]

Etymology

Psychotherapy is an English word of Greek origin, deriving from Ancient Greek psyche (ψυχή meaning "breath; spirit; soul") and therapeia (θεραπεία "healing; medical treatment").

According to the Oxford English Dictionary, psychotherapy first meant "hypnotherapy" instead of "psychotherapy". The original meaning, "the treatment of disease by ‘psychic’ [i.e., hypnotic] methods", was first recorded in 1853 as "Psychotherapeia, or the remedial influence of mind". The modern meaning, "the treatment of disorders of the mind or personality by psychological or psychophysiological methods", was first used in 1892 by Frederik van Eeden translating "Suggestive Psycho-therapy" for his French "Psychothérapie Suggestive". Van Eeden credited borrowing this term from Daniel Hack Tuke and noted, "Psycho-therapy ... had the misfortune to be taken in tow by hypnotism."[14]

The psychiatrist Jerome Frank defined psychotherapy as the relief of distress or disability in one person by another, using an approach based on a particular theory or paradigm, and a requirement that the agent performing the therapy has had some form of training in delivering this. It is these latter two points which distinguish psychotherapy from other forms of counseling or caregiving.[15] In the United States, a councilor is defined as one who provides specific help for a particular need such as addiction where a therapist works on a broader range of issues and generally for a longer period of time.[16]
Psychologist Hans J. Eysenck in explaining the relationship between psychotherapy, behavior therapy and behavior modification defines it in its broadest sense as "the use of psychological theories and methods in the treatment of psychiatric disorders." He goes on to state that psychotherapy "has a narrower meaning, namely the use of interpretative (mostly Freudian) methods of therapy."[17]

Forms

Most forms of psychotherapy use spoken conversation. Some also use various other forms of communication such as the written word, artwork, drama, narrative story or music. Psychotherapy with children and their parents often involves play, dramatization (i.e. role-play), and drawing, with a co-constructed narrative from these non-verbal and displaced modes of interacting.[18] Psychotherapy occurs within a structured encounter between a trained therapist and client(s). Purposeful, theoretically based psychotherapy began in the 19th century with psychoanalysis; since then, scores of other approaches have been developed and continue to be created.

Therapy is generally used in response to a variety of specific or non-specific manifestations of clinically diagnosable and/or existential crises. Treatment of everyday problems is more often referred to as counseling (a distinction originally adopted by Carl Rogers). However, the term counseling is sometimes used interchangeably with "psychotherapy".

While some psychotherapeutic interventions are designed to treat the patient using the medical model, many psychotherapeutic approaches do not adhere to the symptom-based model of "illness/cure". Some practitioners, such as humanistic therapists, see themselves more in a facilitative/helper role. As sensitive and deeply personal topics are often discussed during psychotherapy, therapists are expected, and usually legally bound, to respect client or patient confidentiality. The critical importance of confidentiality is enshrined in the regulatory psychotherapeutic organizations' codes of ethical practice.

Systems


There are several main broad systems of psychotherapy:
  • Psychoanalytic - This was the first practice to be called a psychotherapy. It encourages the verbalization of all the patient's thoughts, including free associations, fantasies, and dreams, from which the analyst formulates the nature of the unconscious conflicts which are causing the patient's symptoms and character problems.
  • Behavior therapy/applied behavior analysis - Focuses on changing maladaptive patterns of behavior to improve emotional responses, cognitions, and interactions with others.
  • Cognitive behavioral - Generally seeks to identify maladaptive cognition, appraisal, beliefs and reactions with the aim of influencing destructive negative emotions and problematic dysfunctional behaviors.
  • Psychodynamic - A form of depth psychology, whose primary focus is to reveal the unconscious content of a client's psyche in an effort to alleviate psychic tension. Although its roots are in psychoanalysis, psychodynamic therapy tends to be briefer and less intensive than traditional psychoanalysis.
  • Existential - Based on the existential belief that human beings are alone in the world. This isolation leads to feelings of meaninglessness, which can be overcome only by creating one's own values and meanings. Existential therapy is philosophically associated with phenomenology.
  • Humanistic - Emerged in reaction to both behaviorism and psychoanalysis and is therefore known as the Third Force in the development of psychology. It is explicitly concerned with the human context of the development of the individual with an emphasis on subjective meaning, a rejection of determinism, and a concern for positive growth rather than pathology. It posits an inherent human capacity to maximize potential, 'the self-actualizing tendency'. The task of Humanistic therapy is to create a relational environment where this tendency might flourish. Humanistic psychology is philosophically rooted in existentialism.
  • Brief - "Brief therapy" is an umbrella term for a variety of approaches to psychotherapy. It differs from other schools of therapy in that it emphasizes (1) a focus on a specific problem and (2) direct intervention. It is solution-based rather than problem-oriented. It is less concerned with how a problem arose than with the current factors sustaining it and preventing change.
  • Systemic - Seeks to address people not at an individual level, as is often the focus of other forms of therapy, but as people in relationship, dealing with the interactions of groups, their patterns and dynamics (includes family therapy & marriage counseling). Community psychology is a type of systemic psychology.
  • Transpersonal - Addresses the client in the context of a spiritual understanding of consciousness.
  • Body Psychotherapy - Addresses problems of the mind as being closely correlated with bodily phenomena, including a person's sexuality, musculature, breathing habits, physiology etc. This therapy may involve massage and other body exercises as well as talking.
There are hundreds of psychotherapeutic approaches or schools of thought. By 1980 there were more than 250;[19] by 1996 there were more than 450.[20]

History

In an informal sense, psychotherapy can be said to have been practiced through the ages, as individuals received psychological counsel and reassurance from others.
According to Colin Feltham, "The Stoics were one of the main Hellenistic schools of philosophy and therapy, along with the Sceptics and Epicureans (Nussbaum, 1994). Philosophers and physicians from these schools practised psychotherapy among the Greeks and Romans from about the late 4th century BC to the 4th century AD."[21] Indeed, Stoic philosophy was explicitly cited by the founders of cognitive therapy and rational-emotive behaviour therapy as the principal precursor and inspiration for their own approaches.[22]

Psychoanalysis was perhaps the first specific school of psychotherapy, developed by Sigmund Freud and others through the early 20th century. Trained as a neurologist, Freud began focusing on problems that appeared to have no discernible organic basis, and theorized that they had psychological causes originating in childhood experiences and the unconscious mind. Techniques such as dream interpretation, free association, transference and analysis of the id, ego and superego were developed. Many theorists, including Anna Freud, Alfred Adler, Carl Jung, Karen Horney, Otto Rank, Erik Erikson, Melanie Klein, and Heinz Kohut, built upon Freud's fundamental ideas and often developed their own systems of psychotherapy. These were all later categorized as psychodynamic, meaning anything that involved the psyche's conscious/unconscious influence on external relationships and the self. Sessions tended to number into the hundreds over several years.

Behaviorism developed in the 1920s, and behavior modification as a therapy became popularized in the 1950s and 1960s. Notable contributors were Joseph Wolpe in South Africa, M.B. Shipiro and Hans Eysenck in Britain, and John B. Watson and B.F. Skinner in the United States. Behavioral therapy approaches relied on principles of operant conditioning, classical conditioning and social learning theory to bring about therapeutic change in observable symptoms. The approach became commonly used for phobias, as well as other disorders.

Some therapeutic approaches developed out of the European school of existential philosophy. Concerned mainly with the individual's ability to develop and preserve a sense of meaning and purpose throughout life, major contributors to the field in the US (e.g., Irvin Yalom, Rollo May) and Europe (Viktor Frankl, Ludwig Binswanger, Medard Boss, R.D.Laing, Emmy van Deurzen) and later in the 1960s and 1970s both in the United Kingdom and in Canada, Eugene Heimler [23][24] attempted to create therapies sensitive to common 'life crises' springing from the essential bleakness of human self-awareness, previously accessible only through the complex writings of existential philosophers (e.g., Søren Kierkegaard, Jean-Paul Sartre, Gabriel Marcel, Martin Heidegger, Friedrich Nietzsche). The uniqueness of the patient-therapist relationship thus also forms a vehicle for therapeutic inquiry. A related body of thought in psychotherapy started in the 1950s with Carl Rogers. Based on existentialism and the works of Abraham Maslow and his hierarchy of human needs, Rogers brought person-centered psychotherapy into mainstream focus. The primary requirement of Rogers is that the client should be in receipt of three core 'conditions' from his counsellor or therapist: unconditional positive regard, also sometimes described as 'prizing' the person or valuing the humanity of an individual, congruence [authenticity/genuineness/transparency], and empathic understanding. The aim in using the 'core conditions' is to facilitate therapeutic change within a non-directive relationship conducive to enhancing the client's psychological well being. This type of interaction enables the client to fully experience and express himself. Others developed the approach, like Fritz and Laura Perls in the creation of Gestalt therapy, as well as Marshall Rosenberg, founder of Nonviolent Communication, and Eric Berne, founder of Transactional Analysis. Later these fields of psychotherapy would become what is known as humanistic psychotherapy today. Self-help groups and books became widespread.

During the 1950s, Albert Ellis originated Rational Emotive Behavior Therapy (REBT). A few years later, psychiatrist Aaron T. Beck developed a form of psychotherapy known as cognitive therapy. Both of these generally included relatively short, structured and present-focused therapy aimed at identifying and changing a person's beliefs, appraisals and reaction-patterns, by contrast with the more long-lasting insight-based approach of psychodynamic or humanistic therapies. Cognitive and behavioral therapy approaches were combined and grouped under the heading and umbrella-term Cognitive behavioral therapy (CBT) in the 1970s. Many approaches within CBT are oriented towards active/directive collaborative empiricism and mapping, assessing and modifying clients core beliefs and dysfunctional schemas. These approaches gained widespread acceptance as a primary treatment for numerous disorders. A "third wave" of cognitive and behavioral therapies developed, including Acceptance and Commitment Therapy and Dialectical behavior therapy, which expanded the concepts to other disorders and/or added novel components and mindfulness exercises. Counseling methods developed, including solution-focused therapy and systemic coaching. During the 1960s and 1970s Eugene Heimler, after training in the new discipline of psychiatric social work, developed Heimler method of Human Social Functioning, a methodology based on the principle that frustration is the potential to human flourishing.[23][24] Positive psychotherapy (PPT) (since 1968) is the name of the method of the psychotherapeutic modality developed by Nossrat Peseschkian and co-workers. Prof. Peseschkian, MD, (1933–2010) was a specialist in neurology, psychiatry, psychotherapy and psychotherapeutic medicine. Positive psychotherapy is a method in the field of humanistic and psychodynamic psychotherapy and is based on a positive image of man, which correlates with a salutogenetic, resource-oriented, humanistic and conflict-centered approach.

Postmodern psychotherapies such as Narrative Therapy and Coherence Therapy did not impose definitions of mental health and illness, but rather saw the goal of therapy as something constructed by the client and therapist in a social context. Systems Therapy also developed, which focuses on family and group dynamics—and Transpersonal psychology, which focuses on the spiritual facet of human experience. Other important orientations developed in the last three decades include Feminist therapy, Brief therapy, Somatic Psychology, Expressive therapy, applied Positive psychology and the Human Givens approach which is building on the best of what has gone before.[25] A survey of over 2,500 US therapists in 2006 revealed the most utilized models of therapy and the ten most influential therapists of the previous quarter-century.[26]

General description

Psychotherapy can be seen as an interpersonal invitation offered by (often trained and regulated) psychotherapists to aid clients in reaching their full potential or to cope better with problems of life. Psychotherapists usually receive remuneration in some form in return for their time and skills. This is one way in which the relationship can be distinguished from an altruistic offer of assistance.

Psychotherapists and counselors are often required to create a therapeutic environment referred to as the frame, which is characterized by a free yet secure climate that enables the client to open up. The degree to which the client feels related to the therapist may well depend on the methods and approaches used by the therapist or counselor.

Psychotherapy often includes techniques to increase awareness and the capacity for self-observation, change behavior and cognition, and develop insight and empathy. Desired results may be to enable other choices of thought, feeling or action, and to increase the sense of well-being and to better manage subjective discomfort or distress. Perception of reality is hopefully improved. Grieving might be enhanced, producing less long-term depression. Psychotherapy can improve medication response where such medication is also needed.[citation needed] Psychotherapy can be provided on a one-to-one basis, in group therapy, conjointly with couples and with entire families. It can occur face to face (individual), over the telephone, or, much less commonly, the Internet. Its time frame may be a matter of weeks or many years. Therapy may address specific forms of diagnosable mental illness, or everyday problems in managing or maintaining interpersonal relationships or meeting personal goals. Treatment in families with children can favorably influence a child's development, lasting for life and into future generations. Better parenting may be an indirect result of therapy or purposefully learned as parenting techniques. Divorces can be prevented or made far less traumatic. Treatment of everyday problems is more often referred to as counseling (a distinction originally adopted by Carl Rogers), but the term is sometimes used interchangeably with "psychotherapy". Therapeutic skills can be used in mental health consultation to business and public agencies to improve efficiency and assist with coworkers or clients.

Psychotherapists use a range of techniques to influence or persuade the client to adapt or change in the direction the client has chosen. These can be based on clear thinking about their options; experiential relationship building; dialogue, communication and adoption of behavior change strategies. Each is designed to improve the mental health of a client or patient, or to improve group relationships (as in a family). Most forms of psychotherapy use only spoken conversation, though some also use other forms of communication, such as the written word, artwork, drama, narrative story, or therapeutic touch. Psychotherapy occurs within a structured encounter between a trained therapist and client(s). Because sensitive topics are often discussed during psychotherapy, therapists are expected, and usually legally bound, to respect client or patient confidentiality.

Psychotherapists are often trained, certified, and licensed, with a range of different certifications and licensing requirements depending on the jurisdiction. Psychotherapy may be undertaken by clinical psychologists, counseling psychologists, rehabilitation counselors, social workers, marriage-family therapists, adult and child psychiatrists and expressive therapists, trained nurses, psychiatrists, psychoanalysts, mental health counselors, school counselors, or professionals of other mental health disciplines.

Psychiatrists have medical qualifications and may also administer prescription medication. The primary training of a psychiatrist uses the 'Bio-Psycho-Social' model, medical training in practical psychology and applied psychotherapy. Psychiatric training begins in medical school, first in the doctor-patient relationship with ill people, and later in psychiatric residency for specialists. The focus is usually eclectic but includes biological, cultural, and social aspects. They are advanced in understanding patients from the inception of medical training. Today there are two doctoral degrees in psychology, the PsyD and PhD. Training for these degrees overlaps, but the PsyD is more clinical and the Phd stresses research. Both degrees have clinical education components. Clinical social workers have specialized training in clinical casework. They hold a masters in social work, which entails two years of clinical internships, and a period of at least three years in the US of post-masters experience in psychotherapy. Marriage-family therapists have specific training and experience working with relationships and family issues. A licensed professional counselor (LPC) generally has special training in career, mental health, school, or rehabilitation counseling, to include evaluation and assessments as well as psychotherapy. Many of the wide variety of training programs are multiprofessional, that is, psychiatrists, psychologists, mental health nurses, and social workers may be found in the same training group. All these degrees commonly work together as a team, especially in institutional settings. All those doing specialized psychotherapeutic work, in most countries, require a program of continuing education after the basic degree, or involve multiple certifications attached to one specific degree, and 'board certification' in psychiatry. Specialty exams, or board exams with psychiatrists, are used to confirm competence.

Medical and non-medical models

A distinction can also be made between those psychotherapies that employ a medical model and those that employ a humanistic model. In the medical model the client is seen as unwell and the therapist employs their skill to help the client back to health. The extensive use of the DSM-IV, the diagnostic and statistical manual of mental disorders in the United States, is an example of a medically exclusive model.

The humanistic model of non medical in contrast strives to depathologise the human condition. The therapist attempts to create a relational environment conducive to experiential learning and help build the client's confidence in their own natural process resulting in a deeper understanding of themselves. An example would be gestalt therapy.

Some psychodynamic practitioners distinguish between more uncovering and more supportive psychotherapy. Uncovering psychotherapy emphasizes facilitating the client's insight into the roots of their difficulties. The best-known example of an uncovering psychotherapy is classical psychoanalysis. Supportive psychotherapy by contrast stresses strengthening the client's defenses and often providing encouragement and advice. Depending on the client's personality, a more supportive or more uncovering approach may be optimal. Most psychotherapists use a combination of uncovering and supportive approaches.

Specific schools and approaches

In practices of experienced psychotherapists, the therapy is typically not of one pure type, but draws aspects from a number of perspectives and schools.[27][28]

Psychoanalysis

Freud, seated left of picture with Jung seated at right of picture. 1909

Psychoanalysis was developed in the late 19th century by Sigmund Freud. His therapy explores the dynamic workings of a mind understood to consist of three parts: the hedonistic id (German: das Es, "the it"), the rational ego (das Ich, "the I"), and the moral superego (das Überich, "the above-I"). Because the majority of these dynamics are said to occur outside people's awareness, Freudian psychoanalysis seeks to probe the unconscious by way of various techniques, including dream interpretation and free association. Freud maintained that the condition of the unconscious mind is profoundly influenced by childhood experiences. So, in addition to dealing with the defense mechanisms used by an overburdened ego, his therapy addresses fixations and other issues by probing deeply into clients' youth.

Other psychodynamic theories and techniques have been developed and used by psychotherapists, psychologists, psychiatrists, personal growth facilitators, occupational therapists and social workers. For example, object relations theory is a psychodynamic theory that has been widely applied to general psychotherapy and to psychiatry by such authors as N. Gregory Hamilton [29][30] and Glen O. Gabbard.[31] Techniques for group therapy have also been developed. While behaviour is often a target of the work, many approaches value working with feelings and thoughts. This is especially true of the psychodynamic schools of psychotherapy, which today include Jungian therapy and Psychodrama as well as the psychoanalytic schools and object relations theory.

Gestalt therapy

Gestalt therapy is a major overhaul of psychoanalysis. In its early development, its founders, Frederick and Laura Perls, called it “concentration therapy”. By the time Gestalt Therapy, Excitement and Growth in the Human Personality by Perls, Hefferline, and Goodman was written in 1951, the approach became known as "Gestalt Therapy".
Gestalt therapy stands on top of essentially four load-bearing theoretical walls: phenomenological method, dialogical relationship, field-theoretical strategies, and experimental freedom. Some[who?] have considered it an existential phenomenology while others[who?] have described it as a phenomenological behaviorism. Gestalt therapy is a humanistic, holistic, and experiential approach that does not rely on talking alone; instead it facilitates awareness in the various contexts of life by moving from talking about relatively remote situations to action and direct current experience.

Positive psychotherapy

Positive psychotherapy (PPT) (since 1968) is the name of the method of the psychotherapeutic modality developed by Nossrat Peseschkian and co-workers. Positive psychotherapy is a method in the field of humanistic and psychodynamic psychotherapy and is based on a positive image of man, which correlates with a salutogenetic, resource-oriented, humanistic and conflict-centered approach. It is accredited by several institutions (e.g. State Medical Chamber of Hessen, Germany, European Association for Psychotherapy EAP; World Council for Psychotherapy WCP, International Federation of Psychotherapy IFP and other statutory institutions).

Group psychotherapy

The term group therapy, was first used around 1920 by Jacob L. Moreno, whose main contribution was the development of psychodrama, in which groups were used as both cast and audience for the exploration of individual problems by reenactment under the direction of the leader. The more analytic and exploratory use of groups in both hospital and out-patient settings was pioneered by a few European psychoanalysts who emigrated to the USA, such as Paul Schilder, who treated severely neurotic and mildly psychotic out-patients in small groups at Bellevue Hospital, New York. The power of groups was most influentially demonstrated in Britain during the Second World War, when several psychoanalysts and psychiatrists proved the value of group methods for officer selection in the War Office Selection Boards. A chance to run an Army psychiatric unit on group lines was then given to several of these pioneers, notably Wilfred Bion and Rickman, followed by S. H. Foulkes, Main, and Bridger. The Northfield Hospital in Birmingham gave its name to what came to be called the two 'Northfield Experiments', which provided the impetus for the development since the war of both social therapy, that is, the therapeutic community movement, and the use of small groups for the treatment of neurotic and personality disorders. Today group therapy is used in clinical settings and in private practice settings.[32]

Cognitive behavioral therapy

Cognitive behavioral therapy (CBT) refers to a range of techniques which focus on the construction and re-construction of people's cognitions, emotions and behaviors. Generally in CBT, the therapist, through a wide array of modalities, helps clients assess, recognize and deal with problematic and dysfunctional ways of thinking, emoting and behaving.

Hypnotherapy

Hypnotherapy is therapy that is undertaken with a subject in hypnosis. Hypnotherapy is often applied in order to modify a subject's behavior, emotional content, and attitudes, as well as a wide range of conditions including dysfunctional habits,[33][34][35][36][37] anxiety,[38] stress-related illness,[39][40][41] pain management,[42][43] and personal development.[44][45]

Behavior therapy

Behavior therapy focuses on modifying overt behavior and helping clients to achieve goals. This approach is built on the principles of learning theory including operant and respondent conditioning, which makes up the area of applied behavior analysis or behavior modification. This approach includes acceptance and commitment therapy, functional analytic psychotherapy, and dialectical behavior therapy. Sometimes it is integrated with cognitive therapy to make cognitive behavior therapy. By nature, behavioral therapies are empirical (data-driven), contextual (focused on the environment and context), functional (interested in the effect or consequence a behavior ultimately has), probabilistic (viewing behavior as statistically predictable), monistic (rejecting mind-body dualism and treating the person as a unit), and relational (analyzing bidirectional interactions).[46]

Body-oriented psychotherapy

Body-oriented psychotherapy or body psychotherapy is also known as Somatic Psychology, especially in the USA. There are many very different body-oriented or somatic psychotherapeutic approaches. They generally focus on the link between the mind and the body and try to access deeper levels of the psyche through greater awareness of the physical body and the emotions which gave rise to the various body-oriented based psychotherapeutic approaches, such as Reichian (Wilhelm Reich) Character-Analytic Vegetotherapy and Orgonomy; neo-Reichian Alexander Lowen's Bioenergetic analysis; Peter Levine's Somatic Experiencing; Jack Rosenberg's Integrative body psychotherapy; Ron Kurtz's Hakomi psychotherapy; Pat Ogden's sensorimotor psychotherapy; David Boadella's Biosynthesis psychotherapy; Gerda Boyesen's Biodynamic psychotherapy; etc. These body-oriented psychotherapies are not to be confused with alternative medicine body-work or body-therapies that seek primarily to improve physical health through direct work (touch and manipulation) on the body because, despite the fact that bodywork techniques (for example Alexander Technique, Rolfing, and the Feldenkrais Method) can also affect the emotions, these techniques are not designed to work on psychological issues, neither are their practitioners so trained.

Expressive therapy

Expressive therapy is a form of therapy that utilizes artistic expression as its core means of treating clients. Expressive therapists use the different disciplines of the creative arts as therapeutic interventions. This includes the modalities dance therapy, drama therapy, art therapy, music therapy, writing therapy, among others. Expressive therapists believe that often the most effective way of treating a client is through the expression of imagination in a creative work and integrating and processing what issues are raised in the act.

Interpersonal psychotherapy

Interpersonal psychotherapy (IPT) is a time-limited psychotherapy that focuses on the interpersonal context and on building interpersonal skills. IPT is based on the belief that interpersonal factors may contribute heavily to psychological problems. It is commonly distinguished from other forms of therapy in its emphasis on interpersonal processes rather than intrapsychic processes. IPT aims to change a person's interpersonal behavior by fostering adaptation to current interpersonal roles and situations.

Narrative therapy

Narrative therapy gives attention to each person's "dominant story" by means of therapeutic conversations, which also may involve exploring unhelpful ideas and how they came to prominence. 
Possible social and cultural influences may be explored if the client deems it helpful.

Integrative psychotherapy[edit]

Integrative psychotherapy is an attempt to combine ideas and strategies from more than one theoretical approach.[47] These approaches include mixing core beliefs and combining proven techniques. Forms of integrative psychotherapy include multimodal therapy, the transtheoretical model, cyclical psychodynamics, systematic treatment selection, cognitive analytic therapy, Internal Family Systems Model, multitheoretical psychotherapy and conceptual interaction. In practice, most experienced psychotherapists develop their own integrative approach over time.

Human givens therapy[edit]

The human givens approach was developed by an Irish and British psychotherapist, Joe Griffin and Ivan Tyrrell. It was first introduced in 1998/9 in the monograph Psychotherapy, Counselling and the Human Givens (Organising Idea)[48] and amplified in the 2003 book Human Givens: A new approach to emotional health and clear thinking.[49] Rather than focusing on symptomatology, the human givens approach works within the framework of emotional needs, such as those for security, autonomy and social connection, which decades of health and social psychology research have shown to be essential for physical and mental health.[50][51][52][53] It is a brief, solution-focused approach which aims to help people identify needs not met, or inadequately or inappropriately met, and to address these using psychoeducation and therapeutic techniques such as cognitive restructuring, cognitive reframing and imaginal exposure – all methods endorsed by the standard-setting National Institute for Health and Clinical Excelllence (NICE).

Adaptations for children

Counseling and psychotherapy must be adapted to meet the developmental needs of children. It is generally held to be one part of an effective strategy for some purposes and not for others. These are four purposes that are generally considered inappropriate or pointless reasons for placing a child in psychotherapy:
  1. To determine why a child originally began misbehaving,
  2. To improve the child's self-esteem,
  3. To make up for inconsistent parenting, and
  4. To make the child capable of coping with a parent's drug addiction, interpersonal relationships, or other serious dysfunction[54]
In addition to therapy for the child, or even instead of it, children may benefit if their parents speak to a therapist, take parenting classes, attend grief counseling, or take other actions to resolve stressful situations that affect the child. Parent management training is a highly effective form of psychotherapy that teaches parents skills to reduce their child's behavior problems.

Many counseling preparation programs include courses in human development. Since children often do not have the ability to articulate thoughts and feelings, counselors will use a variety of media such as crayons, paint, clay, puppets, bibliocounseling (books), toys, board games, et cetera. The use of play therapy is often rooted in psychodynamic theory, but other approaches such as Solution Focused Brief Counseling may also employ the use of play in counseling. In many cases the counselor may prefer to work with the care taker of the child, especially if the child is younger than age four. Yet, by doing so, the counselor risks the perpetuation of maladaptive interactive patterns and the adverse effects on development that have already been affected on the child's end of the relationship.[55]
Therefore, contemporary thinking on working with this young age group has leaned towards working with parent and child simultaneously within the interaction, as well as individually as needed.[56][57]

Confidentiality

Confidentiality is an integral part of the therapeutic relationship and psychotherapy in general. It includes protecting specific groups of people, like children, while treating private information in a manner that is in line with a professional ethics code.

Criticisms and questions regarding effectiveness

Within the psychotherapeutic community there has been some discussion of empirically based psychotherapy.[58]

Virtually no comparisons of different psychotherapies with long follow-up times have been done.[59] The Helsinki Psychotherapy Study[60] is a randomized clinical trial, in which patients were monitored for 10 years after the onset of short-term (6 months) psychodynamic or solution-focused, or long-term (3 years) psychodynamic study treatments. The effectiveness, suitability and sufficiency of the therapies were compared also with that of psychoanalysis (5 years), within a quasi-experimental design. The assessments were completed at the baseline and 14 times thereafter during the follow-up. The results of the 3- and 5-year follow-up indicate that the length of therapy is important when predicting the outcome of therapy. Patients in the two short-term therapies improved faster, but in the long run long-term psychotherapy and psychoanalysis gave greater benefits. Several patient and therapist factors appear to predict suitability for different psychotherapies. Follow-up evaluations of this study will continue up to 2014.

There is considerable controversy about which form of psychotherapy is most effective, and more specifically, which types of therapy are optimal for treating which sorts of problems.[61] Furthermore, it is controversial whether the form of therapy or the presence of factors common to many psychotherapies best separates effective therapy from ineffective therapy. Common factors theory asserts it is precisely the factors common to the most psychotherapies that make any psychotherapy successful: this is the quality of the therapeutic relationship.

The dropout level is quite high; one meta-analysis of 125 studies concluded that the mean dropout rate was 46.86%.[62] The high level of dropout has raised some criticism about the relevance and efficacy of psychotherapy.[63] There are different drop-out rates depending on how drop-out is defined. Another large meta-analysis reports drop-out rates not larger than 20 to 25%.[64]

Psychotherapy outcome research—in which the effectiveness of psychotherapy is measured by questionnaires given to patients before, during, and after treatment—has had difficulty distinguishing between the success or failure of the different approaches to therapy. Those who stay with their therapist for longer periods are more likely to report positively on what develops into a longer-term relationship. This suggests that some "treatment" may be open-ended with concerns associated with ongoing financial costs.

As early as 1952, in one of the earliest studies of psychotherapy treatment, Hans Eysenck reported that two thirds of therapy patients improved significantly or recovered on their own within two years, whether or not they received psychotherapy.[65]

In 1994 the late Frank Pittman published "A Buyer's Guide To Psychotherapy," calling psychotherapy a decision about "whose wisdom to buy" while questioning the value of a profession he had practiced for more than three decades:[66]
“For 33 years as a psychotherapist, I've sold myself by the hour … I used to be proud of what I did. That has changed. Perhaps it was the unsettling experience of trying to explain to friends from abroad—for whom American psychotherapy is a foreign culture—how perennial psychotherapy customer Woody Allen could have undergone therapy for most of his life and still not have seen anything incestuous in his sexual relationship with his de facto stepdaughter, the sister of his children. When asked about his analyst's reaction, Allen is rumored to have said, ‘It didn't come up. It wasn't a relevant issue for my therapy.’”[66]
Many psychotherapists believe that the nuances of psychotherapy cannot be captured by questionnaire-style observation, and prefer to rely on their own clinical experiences and conceptual arguments to support the type of treatment they practice.

In 2001, Bruce Wampold of the University of Wisconsin published the book The Great Psychotherapy Debate.[67] In it Wampold, who has a degree in mathematics and who went on to train as a counseling psychologist, reported that:
  1. Psychotherapy is indeed effective
  2. The type of treatment is not a factor
  3. The theoretical bases of the techniques used and the strictness of adherence to those techniques are both not factors
  4. The therapist's strength of belief in the efficacy of the technique is a factor
  5. The personality of the therapist is a significant factor
  6. The alliance between the patient(s) and the therapist (meaning affectionate and trusting feelings toward the therapist, motivation and collaboration of the client, and empathic response of the therapist) is a key factor
Wampold therefore concludes that "we do not know why psychotherapy works".

Although the Great Psychotherapy Debate dealt primarily with data on depressed patients, subsequent articles have made similar findings for post-traumatic stress disorder[68] and youth disorders.[69] There have also been studies of Panic Disorder, where treatment effectiveness is measured in the abatement of panic attacks. Psychoanalytic psychotherapy has been found to be as effective as Cognitive Behavioral Therapy for immediate relief and more effective over the long term.[70][71]

Some report that by attempting to program or manualize treatment, psychotherapists may be reducing efficacy, although the unstructured approach of many psychotherapists cannot appeal to those patients motivated to solve their difficulties through the application of specific techniques different from their past "mistakes."

Critics of psychotherapy are skeptical of the healing power of a psychotherapeutic relationship.[72] Because any intervention takes time, critics note that the passage of time alone, without therapeutic intervention, often results in psycho-social healing.[73][74] Social contact with others is universally seen as beneficial for all humans and regularly scheduled visits with anyone would be likely to diminish both mild and severe emotional difficulty. Yet a large part of effectiveness studies include waiting-list control groups. This type of study design proves psychotherapy to be significantly more effective than passage of time alone.[75]

Many resources available to a person experiencing emotional distress—the friendly support of friends, peers, family members, clergy contacts, personal reading, healthy exercise, research, and independent coping—all present considerable value. Critics note that humans have been dealing with crises, navigating severe social problems and finding solutions to life problems long before the advent of psychotherapy.[76] Of course, it may well be something in the patient that does not develop these "natural" supports that requires therapy.

Further critiques have emerged from feminist, constructionist and discursive sources. Key to these is the issue of power. In this regard there is a concern that clients are persuaded—both inside and outside the consulting room—to understand themselves and their difficulties in ways that are consistent with therapeutic ideas. This means that alternative ideas (e.g., feminist, economic, spiritual) are sometimes implicitly undermined. Critics suggest that we idealize the situation when we think of therapy only as a helping relation, that it is fundamentally a political practice, in that some cultural ideas and practices are supported while others are undermined or disqualified, and while it is seldom intended, the therapist-client relationship always participates in society's power relations and political dynamics.[77]

Cancer research


From Wikipedia, the free encyclopedia

Cancer research is basic research into cancer in order to identify causes and develop strategies for prevention, diagnosis, treatments and cure.

Cancer research ranges from epidemiology, molecular bioscience to the performance of clinical trials to evaluate and compare applications of the various cancer treatment. These applications include surgery, radiation therapy, chemotherapy, hormone therapy, Immunotherapy and combined treatment modalities such as chemo-radiotherapy. Starting in the mid-1990s, the emphasis in clinical cancer research shifted towards therapies derived from biotechnology research, such as cancer immunotherapy and gene therapy.

Areas of research

Cause

Early research on the cause of cancer was summarized by Haddow in 1958.[1] The first chemical carcinogen was identified in 1928-29 as 1:2-5:6-dibenzanthracene, and the carcinogeneic substance in pitch was identified as 3:4-benzopyrene in 1933. Haddow concluded that “there can be little doubt of the importance of their [chemical] combination with the genetical material” as the source of the chemical mechanism of action of carcinogens. Brookes and Lawley, in 1964, summarized ongoing research into the causes of cancer.[2] They referred to the competing hypotheses that carcinogens reacted mainly with proteins versus mainly with DNA. The direct research of Brookes and Lawley, testing carcinogenic hydrocarbons, indicated that they react with DNA. McCann et al.[3] in 1975 and McCann and Ames, in 1976,[4] tested 175 known carcinogens for interaction with DNA sufficient to cause mutations in their new Salmonella/microsome test. This test uses bacteria as sensitive indicators of DNA damage. They found that 90% of known carcinogens caused mutations in their test. They indicated that the carcinogens that did not cause mutations in their assay were likely due to the need for the carcinogens to be activated by enzymes not available in their system.

By 1981, Doll and Peto conducted an epidemiological study in which they compared cancer rates for 37 specific cancers in the United States to rates for these cancers in populations in which the incidence of these cancers is low.[5] The populations compared with US populations included Norwegians, Nigerians, Japanese, British, and Israeli Jews. Their conclusion was that 75 - 80% of the cases of cancer in the United States were likely avoidable. The avoidable sources of cancer included tobacco, alcohol, diet (especially meat and fat), food additives, occupational exposures (including aromatic amines, benzene, heavy metals, vinyl chloride), pollution, industrial products, medicines and medical procedures, UV light from the sun, exposure to medical x-rays, and infection. Many of these sources of cancer are DNA damaging agents.

More recent research, indicating both the role of DNA damage in causing cancer and other factors including reduced expression of DNA repair genes by epigenetic alterations (allowing DNA damages to accumulate) are summarized in Carcinogenesis and in an article by Bernstein et al. in 2013.[6]

Research into the cause of cancer involves many different disciplines including genetics, diet, environmental factors (i.e. chemical carcinogens). In regard to investigation of causes and potential targets for therapy, the route used starts with data obtained from clinical observations, enters basic research, and, once convincing and independently confirmed results are obtained, proceeds with clinical research, involving appropriately designed trials on consenting human subjects, with the aim to test safety and efficiency of the therapeutic intervention method. An important part of basic research is characterization of the potential mechanisms of carcinogenesis, in regard to the types of genetic and epigenetic changes that are associated with cancer development. The mouse is often used as a mammalian model for manipulation of the function of genes that play a role in tumor formation, while basic aspects of tumor initiation, such as mutagenesis, are assayed on cultures of bacteria and mammalian cells.

Important cell types involved in cancer growth

There are several different cell types that are critical to tumor growth. In particular Endothelial Progenitor Cells are a very important cell population in tumor blood vessel growth. This finding was demonstrated in the high impact factor journals of Science (2008) and Genes and Development (2007)which also showed that Endothelial Progenitor Cells are critical for metastasis and the angiogenesis.[7][8] This importance of endothelial progenitor cells in tumour growth and angiogenesis has been confirmed by a recent publication in Cancer Research (August 2010). This seminal paper has demonstrated that endothelial progenitor cells can be marked using the Inhibitor of DNA Binding 1 (ID1). This novel finding meant that investigators were able to track endothelial progenitor cells from the bone marrow to the blood to the tumour-stroma and even incorporated in tumour vasculature. This finding of endothelial progenitor cells incorporated in tumour vasculature proves the importance of this cell type in blood vessel development in a tumour setting. Furthermore, ablation of the endothelial progenitor cells in the bone marrow lead to a significant decrease in tumour growth and vasculature development. Therefore endothelial progenitor cells are very important in tumour biology and present novel therapeutic targets.[9]

In vitro research using cell lines


Electroporation is used extensively in cancer research for gene and drug delivery. Gemini X2 system manufactured by BTX Harvard Apparatus

In vitro assays allow scientists to conduct studies under reasonable conditions in the lab. In order to study the communication between a tumor cell and a host cell in vitro assays have been created. The use of fragmented chicken heart cells as a host case for nutrients[10] Thus allowing the HeLa cells to, in a sense win, and over take the PHF. In the case of the L tumor cells, they were not able to invade the PHF. Though HeLa cells were able to accomplish invasion after several hours the L cells are structurally different rendering them inadequate. The L cells have much more intercellular free space and do not surround the host cell as tightly as Hela cells. It was concluded that with a tight gap junction nutrients cannot enter the cell allowing the cancer cells to invade. With this information about the gap junction process between host cell and the tumor cell, further studies were conducted in cancer gene therapy with the use of Hela cells and the herpes virus.[11]

Oncogenomics/Genes involved in cancer

The goal of oncogenomics is to identify new oncogenes or tumor suppressor genes that may provide new insights into cancer diagnosis, predicting clinical outcome of cancers, and new targets for cancer therapies. As the Cancer Genome Project stated in a 2004 review article, "a central aim of cancer research has been to identify the mutated genes that are causally implicated in oncogenesis (cancer genes)."[12] The Cancer Genome Atlas project is a related effort investigating the genomic changes associated with cancer, while the COSMIC cancer database documents acquired genetic mutations from hundreds of thousands of human cancer samples.[13]
These large scale projects, involving about 350 different types of tumour, have identified ~130,000 mutations in ~3000 genes that have been mutated in the tumours. The majority occurred in 319 genes of which 286 were tumour suppressor genes and 33 oncogenes.

Several hereditary factors can increase the chance of cancer-causing mutations, including the activation of oncogenes or the inhibition of tumor suppressor genes. The functions of various onco- and tumor suppressor genes can be disrupted at different stages of tumor progression. Mutations in such genes can be used to classify the malignancy of a tumor.

In later stages, tumors can develop a resistance to cancer treatment. The identification of oncogenes and tumor suppressor genes is important to understand tumor progression and treatment success. The role of a given gene in cancer progression may vary tremendously, depending on the stage and type of cancer involved.[14]

Genes and protein products that have been identified by at least two independent publications as being involved in cancer are:[12]

ABI1, ABL2, ACSL6, AF1Q, AF5Q31 (also known as MCEF), AKT1, ARNT, ASPSCR1, ATF1, ATIC, BCL10, BFHD, BIRC3, BMPR1A, BTG1, CBFA2T1, CBFA2T3, CBFB, CCND1, CDC2, CDK4, CHIC2, CHN1, COPEB, COX6C, CTNNB1, CYLD, DDB2, DDIT3, DEK, Eif4a, EIF4A2, EPS15, ERCC2, ERCC3, ERCC5, ERG, ETV4, ETV6, EWSR1, EXT1, EXT2, FANCC, FANCG, FGFR1OP, FGFR3, FH, FIP1L1, FUS, GAS7, GATA1, GMPS, GOLGA5, GPC (gene), GPHN, HIST1H4I, HRAS, HSPCA, IL21R, IIRF4, KRAS2, LASP1, LCP1, LHFP, LMO2, LYL1, MADH4, MEIS1, MLF1, MLH1, MLLT3, MLLT6, MNAT1, MSF, MSH2, MSN, MUTYH, MYC, NCOA4, NF2, NPM1, NRAS, PAX8, PCBD, PDGFB, PHOX2B, PIM1, PLK2, PNUTL1, POU2F1, PPARG, PRCC, PRKACB, PRKAR1A, PTEN, PTPN11, RABEP1, RAD51L1, RAP1GDS1, RARA, RB1, RET, RHOH, RPL22, SBDS, SDHB, SEPTIN6, SET, SH3GL1, SS18L1, SSX1, SSX2, SSX4, STAT3, TAF15, TCF12, TCL1A, TFE3, TFEB, TFG, TFPT, TFRC, TNFRSF6, TP53, TPM3, TPM4, TRIP11, VHL, WAS, WT1, ZNF198, ZNF278, ZNF384, ZNFN1A1

Treatment

Current topics of cancer treatment research include:

Vaccines

Flaws and vulnerabilities

Newsweek magazine published an article criticising the use of lab rats on cancer research because even though researchers frequently manage to cure lab mice transplanted with human tumors, few of those achievements are relevant to humanity.[19] Oncologist Paul Bunn, from the International Association for the Study of Lung Cancer[20] said: "We put a human tumor under the mouse's skin, and that microenvironment doesn't reflect a person's—the blood vessels, inflammatory cells or cells of the immune system".[19] Fran Visco founder of the National Breast Cancer Coalition completed: "We cure cancer in animals all the time, but not in people."[19]

Most funding for cancer research comes from taxpayers and charities, rather than from profit-making businesses. In the US, less than 30% of all cancer research is funded by commercial researchers such as pharmaceutical companies.[21] Per capita, public spending on cancer research by taxpayers and charities in the US was five times as much in 2002-03 as public spending by taxpayers and charities in the 15 countries then full members of the European Union.[21] As a percentage of GDP, the non-commercial funding of cancer research in the US was four times the amount dedicated to cancer research in Europe.[21] Half of Europe's non-commercial cancer research is funded by charitable organizations.[21]

Cancer research processes have been criticised in many respects. These include, especially in the US, hypercompetition for the financial resources and positions required to conduct science, which seems to suppress the creativity, cooperation, risk-taking, and original thinking required to make fundamental discoveries, unduly favoring low-risk research into small incremental advancements over innovative research that might discover radically new and dramatically improved therapy. Other consequences of today's highly pressured competition for research resources appear to be a substantial number of research publications whose results cannot be replicated, and perverse incentives in research funding that encourage grantee institutions to grow without making sufficient investments in their own faculty and facilities.[22][23][24][25]

Distributed computing

One can share computer time for distributed cancer research projects like Help Conquer Cancer.[26] World Community Grid also had a project called Help Defeat Cancer. Other related projects include the Folding@home and Rosetta@home projects, which focus on groundbreaking protein folding and protein structure prediction research.

Organizations


Lie group

From Wikipedia, the free encyclopedia https://en.wikipedia.org/wiki/Lie_group In mathematics , a Lie gro...