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Monday, February 23, 2015

Environmental movement



From Wikipedia, the free encyclopedia


Apollo 8's Earthrise, December 24, 1968

The environmental movement (sometimes referred to as the ecology movement), also including conservation and green politics, is a diverse scientific, social, and political movement for addressing environmental issues. Environmentalists advocate the sustainable management of resources and stewardship of the environment through changes in public policy and individual behavior. In its recognition of humanity as a participant in (not enemy of) ecosystems, the movement is centered on ecology, health, and human rights.

The environmental movement is an international movement, represented by a range of organizations, from the large to grassroots and varies from country to country. Due to its large membership, varying and strong beliefs, and occasionally speculative nature, the environmental movement is not always united in its goals. The movement also encompasses some other movements with a more specific focus, such as the climate movement. At its broadest, the movement includes private citizens, professionals, religious devotees, politicians, scientists, nonprofit organizations and individual advocates.

History

Early awareness


Levels of air pollution rose during the Industrial Revolution, sparking the first modern environmental laws to be passed in the mid-19th century.

Early interest in the environment was a feature of the Romantic movement in the early 19th century. The poet William Wordsworth had travelled extensively in the Lake District and wrote that it is a "sort of national property in which every man has a right and interest who has an eye to perceive and a heart to enjoy".[1]

The origins of the environmental movement lay in the response to increasing levels of smoke pollution in the atmosphere during the Industrial Revolution. The emergence of great factories and the concomitant immense growth in coal consumption gave rise to an unprecedented level of air pollution in industrial centers; after 1900 the large volume of industrial chemical discharges added to the growing load of untreated human waste.[2] Under increasing political pressure from the urban middle-class, the first large-scale, modern environmental laws came in the form of Britain's Alkali Acts, passed in 1863, to regulate the deleterious air pollution (gaseous hydrochloric acid) given off by the Leblanc process, used to produce soda ash.

Conservation movement

Students from the forestry school at Oxford, on a visit to the forests of Saxony in the year 1892.

The modern conservation movement was first manifested in the forests of India, with the practical application of scientific conservation principles. The conservation ethic that began to evolve included three core principles: that the human activity damaged the environment, that there was a civic duty to maintain the environment for future generations, and that scientific, empirically based methods should be applied to ensure this duty was carried out. Sir James Ranald Martin was prominent in promoting this ideology, publishing many medico-topographical reports that demonstrated the scale of damage wrought through large-scale deforestation and desiccation, and lobbying extensively for the institutionalization of forest conservation activities in British India through the establishment of Forest Departments.[3] The Madras Board of Revenue started local conservation efforts in 1842, headed by Alexander Gibson, a professional botanist who systematically adopted a forest conservation program based on scientific principles. This was the first case of state management of forests in the world.[4] Eventually, the government under Governor-General Lord Dalhousie introduced the first permanent and large-scale forest conservation program in the world in 1855, a model that soon spread to other colonies, as well the United States. In 1860, the Department banned the use shifting cultivation.[5] Dr. Hugh Cleghorn's 1861 manual, The forests and gardens of South India, became the definitive work on the subject and was widely used by forest assistants in the subcontinent.[6][7]

Sir Dietrich Brandis joined the British service in 1856 as superintendent of the teak forests of Pegu division in eastern Burma. During that time Burma's teak forests were controlled by militant Karen tribals. He introduced the "taungya" system,[8] in which Karen villagers provided labour for clearing, planting and weeding teak plantations. He formulated new forest legislation and helped establish research and training institutions. The Imperial Forest School at Dehradun was founded by him.[9][10]

Formation of environmental protection societies

The late 19th century saw the formation of the first wildlife conservation societies. The zoologist Alfred Newton published a series of investigations into the Desirability of establishing a 'Close-time' for the preservation of indigenous animals between 1872 and 1903. His advocacy for legislation to protect animals from hunting during the mating season led to the formation of the Plumage League (later the Royal Society for the Protection of Birds) in 1889.[11] The society acted as a protest group campaigning against the use of great crested grebe and kittiwake skins and feathers in fur clothing.[12] The Society attracted growing support from the suburban middle-classes,[11] and influenced the passage of the Sea Birds Preservation Act in 1869 as the first nature protection law in the world.[13][14]

For most of the century from 1850 to 1950, however, the primary environmental cause was the mitigation of air pollution. The Coal Smoke Abatement Society was formed in 1898 making it one of the oldest environmental NGOs. It was founded by artist Sir William Blake Richmond, frustrated with the pall cast by coal smoke. Although there were earlier pieces of legislation, the Public Health Act 1875 required all furnaces and fireplaces to consume their own smoke.

John Ruskin an influential thinker who articulated the Romantic ideal of environmental protection and conservation.

Systematic and general efforts on behalf of the environment only began in the late 19th century; it grew out of the amenity movement in Britain in the 1870s, which was a reaction to industrialization, the growth of cities, and worsening air and water pollution. Starting with the formation of the Commons Preservation Society in 1865, the movement championed rural preservation against the encroachments of industrialisation. Robert Hunter, solicitor for the society, worked with Hardwicke Rawnsley, Octavia Hill, and John Ruskin to lead a successful campaign to prevent the construction of railways to carry slate from the quarries, which would have ruined the unspoilt valleys of Newlands and Ennerdale. This success led to the formation of the Lake District Defence Society (later to become The Friends of the Lake District).[15]

In 1893 Hill, Hunter and Rawnsley agreed to set up a national body to coordinate environmental conservation efforts across the country; the "National Trust for Places of Historic Interest or Natural Beauty" was formally inaugurated in 1894.[16] The organisation obtained secure footing through the 1907 National Trust Bill, which gave the trust the status of a statutory corporation.[17] and the bill was passed in August 1907.[18]

An early "Back-to-Nature" movement, which anticipated the romantic ideal of modern environmentalism, was advocated by intellectuals such as John Ruskin, William Morris, and Edward Carpenter, who were all against consumerism, pollution and other activities that were harmful to the natural world.[19] The movement was a reaction to the urban conditions of the industrial towns, where sanitation was awful, pollution levels intolerable and housing terribly cramped. Idealists championed the rural life as a mythical Utopia and advocated a return to it. John Ruskin argued that people should return to a small piece of English ground, beautiful, peaceful, and fruitful. We will have no steam engines upon it . . . we will have plenty of flowers and vegetables . . . we will have some music and poetry; the children will learn to dance to it and sing it.[20]

Practical ventures in the establishment of small cooperative farms were even attempted and old rural traditions, without the "taint of manufacture or the canker of artificiality", were enthusiastically revived, including the Morris dance and the maypole.[21]

Original title page of Walden by Henry David Thoreau.

The movement in the United States began in the late 19th century, out of concerns for protecting the natural resources of the West, with individuals such as John Muir and Henry David Thoreau making key philosophical contributions. Thoreau was interested in peoples' relationship with nature and studied this by living close to nature in a simple life. He published his experiences in the book Walden, which argues that people should become intimately close with nature. Muir came to believe in nature's inherent right, especially after spending time hiking in Yosemite Valley and studying both the ecology and geology. He successfully lobbied congress to form Yosemite National Park and went on to set up the Sierra Club in 1892. The conservationist principles as well as the belief in an inherent right of nature were to become the bedrock of modern environmentalism. However, the early movement in the U.S. developed with a contradiction; preservationists like John Muir wanted land and nature set aside for its own sake, and conservationists, such as Gifford Pinchot (appointed as the first Chief of the US Forest Service from 1905-1910), wanted to manage natural resources for human use.

20th century

In the 20th century, environmental ideas continued to grow in popularity and recognition. Efforts were starting to be made to save some wildlife, particularly the American bison. The death of the last passenger pigeon as well as the endangerment of the American bison helped to focus the minds of conservationists and popularize their concerns. In 1916 the National Park Service was founded by US President Woodrow Wilson. Pioneers of the movement called for more efficient and professional management of natural resources. They fought for reform because they believed the destruction of forests, fertile soil, minerals, wildlife and water resources would lead to the downfall of society.[22] The group that has been the most active in recent years is the climate movement.
The conservation of natural resources is the fundamental problem. Unless we solve that problem, it will avail us little to solve all others.
Theodore Roosevelt (October 4, 1907)[23]

The U.S movement did not really take off until after World War II as people began to recognize the costs of environmental negligence, disease, and widespread air and water pollution through the occurrence of several environmental disasters that occurred post-World War II. Aldo Leopold wrote "A Sand County Almanac" in the 1940s. He believed in a land ethics that stated "The greatest good for the greatest number of people"; he believed in ecological awareness and preservation of ecosystems.

Another important book in the promotion of the environmental movement was Rachel Carson's "Silent Spring" about declining bird populations due to DDT, an insecticide, pollution and man's attempts to control nature through use of synthetic substances. Both of these books helped bring the issues into the public eye [22] Rachel Carson's "Silent Spring" sold over two million copies.[24]

Earth Day 2007 at City College, San Diego

The first Earth Day was celebrated on 22 April 1970. Its founder, former Wisconsin Senator, Gaylord Nelson was inspired to create this day of environmental education and awareness after seeing the oil spill off the coast of Santa Barbara in 1969. Greenpeace was created in 1971 as an organization that believed that political advocacy and legislation were ineffective or inefficient solutions and supported non-violent action. 1980 saw the creation of Earth First!, a group with an ecocentric view of the world --- believing in equality between the rights of humans to flourish, the rights of all other species to flourish and the rights of life-sustaining systems to flourish.[22]

In the 1950s, 1960s, and 1970s, several events illustrated the magnitude of environmental damage caused by humans. In 1954, a hydrogen bomb test at Bikini Atoll exposed the 23 man crew of the Japanese fishing vessel Lucky Dragon 5 to radioactive fallout. In 1967 the oil tanker Torrey Canyon ran aground off the coast of Cornwall, and in 1969 oil spilled from an offshore well in California's Santa Barbara Channel. In 1971, the conclusion of a lawsuit in Japan drew international attention to the effects of decades of mercury poisoning on the people of Minamata.[25]

At the same time, emerging scientific research drew new attention to existing and hypothetical threats to the environment and humanity. Among them were Paul R. Ehrlich, whose book The Population Bomb (1968) revived Malthusian concerns about the impact of exponential population growth. Biologist Barry Commoner generated a debate about growth, affluence and "flawed technology." Additionally, an association of scientists and political leaders known as the Club of Rome published their report The Limits to Growth in 1972, and drew attention to the growing pressure on natural resources from human activities.

Meanwhile, technological accomplishments such as nuclear proliferation and photos of the Earth from outer space provided both new insights and new reasons for concern over Earth's seemingly small and unique place in the universe.

In 1972, the United Nations Conference on the Human Environment was held in Stockholm, and for the first time united the representatives of multiple governments in discussion relating to the state of the global environment. This conference led directly to the creation of government environmental agencies and the UN Environment Program.

By the mid-1970s anti-nuclear activism had moved beyond local protests and politics to gain a wider appeal and influence. Although it lacked a single co-ordinating organization the anti-nuclear movement's efforts gained a great deal of attention, especially in the United Kingdom and United States.[26] In the aftermath of the Three Mile Island accident in 1979, many mass demonstrations took place. The largest one was held in New York City in September 1979 and involved 200,000 people.[27][28][29]

Since the 1970s, public awareness, environmental sciences, ecology, and technology have advanced to include modern focus points like ozone depletion, global climate change, acid rain, and the potentially harmful genetically modified organisms (GMOs).

United States

Beginning in the conservation movement at the beginning of the 20th century, the contemporary environmental movement's roots can be traced back to Murray Bookchin's Our Synthetic Environment, Paul R. Ehrlich's The Population Bomb, and Rachel Carson's Silent Spring. American environmentalists have campaigned against nuclear weapons and nuclear power in 1960s and 1970s, acid rain in the 1980s, ozone depletion and deforestation in the 1990s, and most recently climate change and global warming.
The United States passed many pieces of environmental legislation in the 1970s, such as the Clean Water Act, the Clean Air Act, the Endangered Species Act, and the National Environmental Policy Act. These remain as the foundations for current environmental standards.

Timeline of US environmental history

  • 1832- Hot Springs Reservation
  • 1864- Yosemite Valley
  • 1872- Yellowstone National Park
  • 1892- Sierra Club
  • 1916- National Park Service Organic Act
  • 1916- National Audubon Society [22]
  • 1949- UN Scientific Conference on the Conservation and Utilization of Resources
  • 1961- World Wildlife Foundation [30]
  • 1964- Land and Water Conservation Act
  • 1964- National Wilderness Preservation System
  • 1968- National Trails System Act
  • 1968- National Wild and Scenic Rivers System/Wild and Scenic Rivers Act[22]
  • 1969- National Environmental Policy Act
  • 1970- First Earth Day- 22 April
  • 1970- Clean Air Act
  • 1970- Environmental Protection Agency [30]
  • 1971- Greenpeace
  • 1972- Clean Water Act
  • 1973- Endangered Species Act
  • 1980- Earth First![22]
  • 1992- UN Earth Summit in Rio de Janeiro [30]

Latin America

After the International Environmental Conference in Stockholm in 1972 Latin American officials returned with a high hope of growth and protection of the fairly untouched natural resources.
Governments spent millions of dollars, and created departments and pollution standards. However, the outcomes have not always been what officials had initially hoped. Activists blame this on growing urban populations and industrial growth. Many Latin American countries have had a large inflow of immigrants that are living in substandard housing. Enforcement of the pollution standards is lax and penalties are minimal; in Venezuela, the largest penalty for violating an environmental law is 50,000 bolivar fine ($3,400) and 3 days in jail. In the 1970s or 1980s many Latin American countries were transitioning from military dictatorships to democratic governments.[31]

In 1992, Brazil came under scrutiny with the United Nations Conference on Environment and Development in Rio de Janeiro. Brazil has a history of little environmental awareness. It has the highest biodiversity in the world and also the highest amount of habitat destruction. One-third of the world's forests lie in Brazil, and they have the largest river, the Amazon, and the largest rainforest, the Amazon Rainforest. The people have raised funds to create state parks and increase the consciousness of people who have destroyed forests and polluted waterways. They have several organizations that have fronted the environmental movement. The Blue Wave Foundation was created in 1989 and has partnered with advertising companies to promote national education campaigns to keep Brazil's beaches clean. Funatura was created in 1986 and is a wildlife sanctuary program. Pro-Nature is a private environmental organization created in 1986.[32]

Europe

In 1952 the Great London Smog episode killed thousands of people and led the UK to create the first Clean Air Act in 1956. In 1957 the first major nuclear accident occurred in Windscale in northern England. The supertanker Torrey Canyon ran aground off the coast of Cornwall in 1967 causing the first major oil leak that killed marine life along the coast. In 1972, in Stockholm, the United Nations Conference on the Human Environment created the UN Environment Programme. The EU's environmental policy was formally founded by a European Council declaration and the first five-year environment programme was adopted. The main idea of the declaration was that prevention is better than the cure and the polluter should pay. 1979 saw the partial meltdown of Three Mile Island in the USA.

In the 1980s the green parties that were created a decade before began to have some political success.. In 1986, there was a nuclear accident in Chernobyl, Ukraine. The end of the 1980s and start of the 1990s saw the fall of communism across central and Eastern Europe, the fall of the [Berlin Wall], and the Union of East and West Germany. In 1992 there was a UN summit held in Rio de Janeiro where Agenda 21 was adopted. The Kyoto Protocol was created in 1997 which set specific targets and deadlines to reduce global greenhouse gas emissions. In the early 2000s activists believed that environmental policy concerns were overshadowed by energy security, globalism, and terrorism.[33]

Asia

Middle East

The environmental movement is reaching the less developed world with different degrees of success. The Arab world, including the Middle East and North Africa, has different adaptations of the environmental movement. Countries on the Persian Gulf have high incomes and rely heavily on the large amount of energy resources in the area. Each country in the Arab world has varying combinations of low or high amounts of natural resources and low or high amounts of labor.

The League of Arab States has one specialized sub-committee, of 12 standing specialized subcommittee in the Foreign Affairs Ministerial Committees, which deals with Environmental Issues. Countries in the League of Arab States have demonstrated an interest in environmental issue, on paper some environmental activists have doubts about the level of commitment to environmental issues;; being a part of the world community may have obliged these countries to portray concern for the environment. Initial level of environmental awareness may be the creation of a ministry of the environment. The year of establishment of a ministry is also indicative of level of engagement. Saudi Arabia was the first to establish environmental law in 1992 followed by Egypt in 1994. Somalia is the only country without environmental law. In 2010 the Environmental Performance Index listed Algeria as the top Arab country at 42 of 163; Morocco was at 52 and Syria at 56. The Environmental Performance Index measures the ability of a country to actively manage and protect their environment and the health of their citizens. A weighted index is created by giving 50% weight for environmental health objective (health) and 50% for ecosystem vitality (ecosystem); values range from 0-100. No Arab countries were in the top quartile, and 7 countries were in the lowest quartile.[34]

Korea & Taiwan

Korea and Taiwan experienced similar growth in industrialization from 1965-1990 with few environmental controls. Korea's Han River and Nakdong River were so polluted by unchecked dumping of industrial waste that they were close to being classified as biologically dead. Taiwan's formula for balanced growth was to prevent industrial concentration and encourage manufacturers to set up in the countryside. This led to 20% of the farmland being polluted by industrial waste and 30% of the rice grown on the island was contaminated with heavy metals. Both countries had spontaneous environmental movements drawing participants from different classes. Their demands were linked with issues of employment, occupational health, and agricultural crisis. They were also quite militant; the people learned that protesting can bring results. The polluting factories were forced to make immediate improvements of the conditions or pay compensation to victims. Some were even forced to shut down or move locations. The people were able to force the government to come out with new restrictive rules on toxins, industrial waste, and air pollution. All of these new regulations caused the migration of those polluting industries from Taiwan and Korea to China and other countries in Southeast Asia with more relaxed environmental laws.[35]

China

China's environmental movement is characterized by spontaneous alliances that often only occur at the local level. The Chinese have realized the ability of riots and protests to have success and had led to an increase in disputes in China by 30% since 2005 to more than 50,000 events. Protests cover topics such as environmental issues, land-loss, income, and political issues. They have also grown in size from about 10 people or fewer in the mid-1990s to 52 people per incident in 2004. China has more relaxed environmental laws than other countries in Asia, so many polluting factories have relocated to China causing pollution in China. Water pollution, water scarcity, soil pollution, soil degradation, and desertification are issues currently in discussion in China. The groundwater table of the North China Plain is dropping by 1.5 m (5 ft) per year. This groundwater table occurs in the region of China that produces 40% of the country's grain.[35][36]

India

Environmental and public health is an ongoing struggle within India. The first seed of an environmental movement in India was the foundation in 1964 of Dasholi Gram Swarajya Sangh, a labour coperative started by Chandi Prasad Bhatt. It was inaugurated by Sucheta Kriplani and founded on a land donated by Shyma Devi. This initiative was eventually followed up with the Chipko movement starting in 1974.

The most severe single event underpinning the movement was the Bhopal gas leakage on 3 December 1984. 40 tons of methyl isocyanate was released, immediately killing 2,259 people and ultimately affecting 700,000 citizens.

India has a national campaign against Coca Cola and Pepsi Cola plants due to their practices of drawing ground water and contaminating fields with sludge. The movement is characterized by local struggles against intensive aquaculture farms. The most influential part of the environmental movement in India is the anti-dam movement. Dam creation has been thought of as a way for India to catch up with the West by connecting to the power grid with giant dams, coal or oil-powered plants, or nuclear plants. Jhola Aandolan a mass movement is conducting as fighting against polyethylene carry bags uses and promoting cloth/jute/paper carry bags to protect environment & nature. Activists in the Indian environmental movement consider global warming, sea levels rising, and glaciers retreating decreasing the amount of water flowing into streams to be the biggest challenges for them to face in the early twenty-first century.[35]

Bangladesh

Mithun Roy Chowdhury, President, Save Nature & Wildlife (SNW), Bangladesh, insisted that the people of Bangladesh raise their voice against Tipaimukh Dam, being constructed by the Government of India. He said Tipaimukh Dam project will be another "death trap for Bangladesh like the Farakka Barrage," that would lead to an environmental disaster for 50 million people in the Meghna River basin. He said that this project will start desertification in Bangladesh.[37][38][39][40]

Scope of the movement


Before flue-gas desulfurization was installed, the air-polluting emissions from this power plant in New Mexico contained excessive amounts of sulfur dioxide.

Environmental science is the study of the interactions among the physical, chemical and biological components of the environment.
  • Ecology, or ecological science, is the scientific study of the distribution and abundance of living organisms and how these properties are affected by interactions between the organisms and their environment.

Primary focus points

The environmental movement is broad in scope and can include any topic related to the environment, conservation, and biology, as well as preservation of landscapes, flora, and fauna for a variety of purposes and uses. See List of environmental issues. When an act of violence is committed against someone or some institution in the name of environmental defense it is referred to as eco terrorism.

Environmental law and theory

Property rights

Many environmental lawsuits question the legal rights of property owners, and whether the general public has a right to intervene with detrimental practices occurring on someone else's land.
Environmental law organizations exist all across the world, such as the Environmental Law and Policy Center in the midwestern United States.

Citizens' rights

One of the earliest lawsuits to establish that citizens may sue for environmental and aesthetic harms was Scenic Hudson Preservation Conference v. Federal Power Commission, decided in 1965 by the Second Circuit Court of Appeals. The case helped halt the construction of a power plant on Storm King Mountain in New York State. See also United States environmental law and David Sive, an attorney who was involved in the case.

Nature's rights

Christopher D. Stone's 1972 essay, "Should trees have standing?" addressed the question of whether natural objects themselves should have legal rights. In the essay, Stone suggests that his argument is valid because many current rightsholders (women, children) were once seen as objects.

Environmental reactivism

Numerous criticisms and ethical ambiguities have led to growing concerns about technology, including the use of potentially harmful pesticides, water additives like fluoride, and the extremely dangerous ethanol-processing plants.

NIMBY syndrome refers to public outcry caused by knee-jerk reaction to an unwillingness to be exposed to even necessary developments. Some serious biologists and ecologists created the scientific ecology movement which would not confuse empirical data with visions of a desirable future world.

Environmentalism today


Composite images of Earth generated by NASA in 2001 (left) and 2002 (right).

Today, the sciences of ecology and environmental science, in addition to any aesthetic goals, provide the basis of unity to some of the serious environmentalists. As more information is gathered in scientific fields, more scientific issues like biodiversity, as opposed to mere aesthetics, are a concern to environmentalists. Conservation biology is a rapidly developing field.

In recent years, the environmental movement has increasingly focused on global warming as one of the top issues. As concerns about climate change moved more into the mainstream, from the connections drawn between global warming and Hurricane Katrina to Al Gore's film An Inconvenient Truth, more and more environmental groups refocused their efforts. In the United States, 2007 witnessed the largest grassroots environmental demonstration in years, Step It Up 2007, with rallies in over 1,400 communities and all 50 states for real global warming solutions.[citation needed]

Many religious organizations and individual churches now have programs and activities dedicated to environmental issues.[44] The religious movement is often supported by interpretation of scriptures.[45] Most major religious groups are represented including Jewish, Islamic, Anglican, Orthodox, Evangelical, Christian and Catholic.[citation needed]

Radical environmentalism

Radical environmentalism emerged from an ecocentrism-based frustration with the co-option of mainstream environmentalism. The radical environmental movement aspires to what scholar Christopher Manes calls "a new kind of environmental activism: iconoclastic, uncompromising, discontented with traditional conservation policy, at times illegal ..." Radical environmentalism presupposes a need to reconsider Western ideas of religion and philosophy (including capitalism, patriarchy[46] and globalization)[47] sometimes through "resacralising" and reconnecting with nature.[46] Greenpeace represents an organisation with a radical approach, but has contributed in serious ways towards understanding of critical issues, and has a science-oriented core with radicalism as a means to media exposure. Groups like Earth First! take a much more radical posture. Some radical environmentalist groups, like Earth First! and the Earth Liberation Front, illegally sabotage or destroy infrastructural capital.

Criticisms

Conservative critics of the movement characterize it as radical and misguided. Especially critics of the United States Endangered Species Act, which has come under scrutiny lately, and the Clean Air Act, which they said conflict with private property rights, corporate profits and the nation's overall economic growth. Critics also challenge scientific evidence for global warming. They argue that the Environmental Movement has diverted attention from more pressing issues.[22] A study reported in The Guardian concluded that "people who believe they have the greenest lifestyles can be seen as some of the main culprits behind global warming." The researchers found that individuals who were more environmentally conscious were more likely to take long-distance overseas flights, and that the resulting carbon emissions outweighed the savings from green lifestyles at home.[48]

Criticisms of environmental organizations

Other criticisms of the environmental movement


Pharmacology



From Wikipedia, the free encyclopedia


A variety of topics involved with pharmacology, including neuropharmacology, renal pharmacology, human metabolism, intracellular metabolism, and intracellular regulation

For the Wikipedia Manual of Style for Pharmacology, see WP:DRUGLIKE

Pharmacology (from Greek Ï†ÎŹÏÎŒÎ±ÎșÎżÎœ, pharmakon, "poison" in classic Greek; "drug" in modern Greek; and -λογία, -logia "study of", "knowledge of") is the branch of medicine and biology concerned with the study of drug action,[1] where a drug can be broadly defined as any man-made, natural, or endogenous (within the body) molecule which exerts a biochemical and/or physiological effect on the cell, tissue, organ, or organism (sometimes the word pharmacon is used as a term to encompass these endogenous and exogenous bioactive species). More specifically, it is the study of the interactions that occur between a living organism and chemicals that affect normal or abnormal biochemical function. If substances have medicinal properties, they are considered pharmaceuticals.

The field encompasses drug composition and properties, synthesis and drug design, molecular and cellular mechanisms, organ/systems mechanisms, signal transduction/cellular communication, molecular diagnostics, interactions, toxicology, chemical biology, therapy, and medical applications and antipathogenic capabilities. The two main areas of pharmacology are pharmacodynamics and pharmacokinetics. The former studies the effects of the drug on biological systems, and the latter the effects of biological systems on the drug. In broad terms, pharmacodynamics discusses the chemicals with biological receptors, and pharmacokinetics discusses the absorption, distribution, metabolism, and excretion (ADME) of chemicals from the biological systems. Pharmacology is not synonymous with pharmacy and the two terms are frequently confused. Pharmacology, a biomedical science, deals with the research, discovery, and characterization of chemicals which show biological effects and the elucidation of cellular and organismal function in relation to these chemicals. In contrast, pharmacy, a health services profession, is concerned with application of the principles learned from pharmacology in its clinical settings; whether it be in a dispensing or clinical care role. In either field, the primary contrast between the two are their distinctions between direct-patient care, for pharmacy practice, and the science-oriented research field, driven by pharmacology.

The origins of clinical pharmacology date back to the Middle Ages in Avicenna's The Canon of Medicine, Peter of Spain's Commentary on Isaac, and John of St Amand's Commentary on the Antedotary of Nicholas.[2] Clinical pharmacology owes much of its foundation to the work of William Withering.[3] Pharmacology as a scientific discipline did not further advance until the mid-19th century amid the great biomedical resurgence of that period.[4] Before the second half of the nineteenth century, the remarkable potency and specificity of the actions of drugs such as morphine, quinine and digitalis were explained vaguely and with reference to extraordinary chemical powers and affinities to certain organs or tissues.[5] The first pharmacology department was set up by Rudolf Buchheim in 1847, in recognition of the need to understand how therapeutic drugs and poisons produced their effects.[4]

Early pharmacologists focused on natural substances, mainly plant extracts. Pharmacology developed in the 19th century as a biomedical science that applied the principles of scientific experimentation to therapeutic contexts.[6] Today Pharmacologists harness the power of genetics, molecular biology, chemistry, and other advanced tools to transform information about molecular mechanisms and targets into therapies directed against disease, defects or pathogens, and create methods for preventative care, diagnostics, and ultimately personalized medicine.

Divisions

The discipline of pharmacology can be divided into many sub disciplines each with a specific focus.

Clinical pharmacology

Clinical pharmacology is the basic science of pharmacology with an added focus on the application of pharmacological principles and methods in the medical clinic and towards patient care and outcomes.

Neuropharmacology

Neuropharmacology is the study of the effects of medication on central and peripheral nervous system functioning.

Psychopharmacology

Psychopharmacology is the study of the effects of medication on the psyche (psychology), observing changed behaviors of the body and mind, and how molecular events are manifest in a measurable behavioral form. This is similar to the closely related ethopharmacology.

Pharmacogenetics

Pharmacogenetics is clinical testing of genetic variation that gives rise to differing response to drugs.

Pharmacogenomics

Pharmacogenomics is the application of genomic technologies to drug discovery and further characterization of older drugs.

Identification of the genetic basis for polymorphic expression of a gene is done through intronic or exomic single-nucleotide polymorphisms (SNPs) which abolishes the need for different mechanisms for explaining the variability in drug metabolism. SNPs based variations in membrane receptors lead to multidrug resistance (MDR) and the drug–drug interactions. Even drug induced toxicity and many adverse effects can be explained by GWA studies. The multitude of SNPs help in understanding gene pharmacokinetic (PK) or pharmacodynamic (PD) pathways.[7]

Pharmacoepidemiology

Pharmacoepidemiology is the study of the effects of drugs in large numbers of people.

Toxicology

Toxicology is the study of the adverse effects, molecular targets, and characterization of drugs or any chemical substance in excess (including those beneficial in lower doses).

Theoretical pharmacology

Theoretical pharmacology is the study of metrics in pharmacology.

Posology

Posology is the study of how medicines are dosed. It also depends upon various factors including age, climate, weight, sex, and time of administration .

Pharmacognosy

Pharmacognosy is a branch of pharmacology dealing especially with the composition, use, and development of medicinal substances of biological origin and especially medicinal substances obtained from plants.

Behavioral pharmacology

Behavioral pharmacology, also referred to as psychopharmacology or ethopharmacology, is an interdisciplinary field which studies behavioral effects of psychoactivedrugs. It incorporates approaches and techniques from neuropharmacology, animal behavior and behavioral neuroscience, and is interested in the behavioral and neurobiological mechanisms of action of psychoactive drugs.
Another goal of behavioral pharmacology is to develop animal behavioral models to screen chemical compounds with therapeutic potentials. People in this field (called behavioral pharmacologists) typically use small animals (e.g. rodents) to study psychotherapeutic drugs such as antipsychotics, antidepressants and anxiolytics, and drugs of abuse such as nicotine, cocaine, methamphetamine, etc.

Environmental pharmacology

Environmental pharmacology is a new discipline.[8] Focus is being given to understand gene–environment interaction, drug-environment interaction and toxin-environment interaction. There is a close collaboration between environmental science and medicine in addressing these issues, as healthcare itself can be a cause of environmental damage or remediation. Human health and ecology are intimately related. Demand for more pharmaceutical products may place the public at risk through the destruction of species. The entry of chemicals and drugs into the aquatic ecosystem is a more serious concern today. In addition, the production of some illegal drugs pollutes drinking water supply by releasing carcinogens.[9] This field is intimately linked with Public Health fields.

Scientific background

The study of chemicals requires intimate knowledge of the biological system affected. With the knowledge of cell biology and biochemistry increasing, the field of pharmacology has also changed substantially. It has become possible, through molecular analysis of receptors, to design chemicals that act on specific cellular signaling or metabolic pathways by affecting sites directly on cell-surface receptors (which modulate and mediate cellular signaling pathways controlling cellular function).

A chemical has, from the pharmacological point-of-view, various properties. Pharmacokinetics describes the effect of the body on the chemical (e.g. half-life and volume of distribution), and pharmacodynamics describes the chemical's effect on the body (desired or toxic).

When describing the pharmacokinetic properties of the chemical that is the active ingredient or active pharmaceutical ingredient (API), pharmacologists are often interested in L-ADME:
  • Liberation – How is the API disintegrated (for solid oral forms (breaking down into smaller particles)), dispersed, or dissolved from the medication?
  • Absorption – How is the API absorbed (through the skin, the intestine, the oral mucosa)?
  • Distribution – How does the API spread through the organism?
  • Metabolism – Is the API converted chemically inside the body, and into which substances. Are these active (as well)? Could they be toxic?
  • Excretion – How is the API excreted (through the bile, urine, breath, skin)?
Medication is said to have a narrow or wide therapeutic index or therapeutic window. This describes the ratio of desired effect to toxic effect. A compound with a narrow therapeutic index (close to one) exerts its desired effect at a dose close to its toxic dose. A compound with a wide therapeutic index (greater than five) exerts its desired effect at a dose substantially below its toxic dose. Those with a narrow margin are more difficult to dose and administer, and may require therapeutic drug monitoring (examples are warfarin, some antiepileptics, aminoglycoside antibiotics). Most anti-cancer drugs have a narrow therapeutic margin: toxic side-effects are almost always encountered at doses used to kill tumors.

Medicine development and safety testing

Development of medication is a vital concern to medicine, but also has strong economical and political implications. To protect the consumer and prevent abuse, many governments regulate the manufacture, sale, and administration of medication. In the United States, the main body that regulates pharmaceuticals is the Food and Drug Administration and they enforce standards set by the United States Pharmacopoeia. In the European Union, the main body that regulates pharmaceuticals is the EMEA and they enforce standards set by the European Pharmacopoeia.

The metabolic stability and the reactivity of a library of candidate drug compounds have to be assessed for drug metabolism and toxicological studies. Many methods have been proposed for quantitative predictions in drug metabolism; one example of a recent computational method is SPORCalc.[10] If the chemical structure of a medicinal compound is altered slightly, this could slightly or dramatically alter the medicinal properties of the compound depending on the level of alteration as it relates to the structural composition of the substrate or receptor site on which it exerts its medicinal effect, a concept referred to as the structural activity relationship (SAR). This means that when a useful activity has been identified, chemists will make many similar compounds called analogues, in an attempt to maximize the desired medicinal effect(s) of the compound. This development phase can take anywhere from a few years to a decade or more and is very expensive.[11]

These new analogues need to be developed. It needs to be determined how safe the medicine is for human consumption, its stability in the human body and the best form for delivery to the desired organ system, like tablet or aerosol. After extensive testing, which can take up to 6 years, the new medicine is ready for marketing and selling.[11]

As a result of the long time required to develop analogues and test a new medicine and the fact that of every 5000 potential new medicines typically only one will ever reach the open market, this is an expensive way of doing things, often costing over 1 billion dollars. To recoup this outlay pharmaceutical companies may do a number of things:[11]
  • Carefully research the demand for their potential new product before spending an outlay of company funds.[11]
  • Obtain a patent on the new medicine preventing other companies from producing that medicine for a certain allocation of time.[11]

Drug legislation and safety

In the United States, the Food and Drug Administration (FDA) is responsible for creating guidelines for the approval and use of drugs. The FDA requires that all approved drugs fulfill two requirements:
  1. The drug must be found to be effective against the disease for which it is seeking approval (where 'effective' means only that the drug performed better than placebo or competitors in at least two trials).
  2. The drug must meet safety criteria by being subject to animal and controlled human testing.
Gaining FDA approval usually takes several years to attain. Testing done on animals must be extensive and must include several species to help in the evaluation of both the effectiveness and toxicity of the drug. The dosage of any drug approved for use is intended to fall within a range in which the drug produces a therapeutic effect or desired outcome.[12]

The safety and effectiveness of prescription drugs in the U.S. is regulated by the federal Prescription Drug Marketing Act of 1987.

The Medicines and Healthcare products Regulatory Agency (MHRA) has a similar role in the UK.

Education

Students of pharmacology are trained as Biomedical Scientists, studying the effects of drugs on living organisms. This can lead to new drug discoveries, as well as a better understanding of the way in which the human body works.

Students of pharmacology must have detailed working knowledge of aspects of physiology, pathology and chemistry. During a typical degree they will cover areas such as (but not limited to) Biochemistry, Biology, Physiology, Genetics, Medical Microbiology and Neuroscience.

Whereas a pharmacy student will eventually work in a pharmacy dispensing medications, a pharmacologist will typically work within a laboratory setting. Careers for a pharmacologist include academic positions (medical and non-medical), governmental positions, private industrial positions, science writing, scientific patents and law, consultation, biotech and pharmaceutical employment, the alcohol industry, food industry, forensics/law enforcement, and public health or environmental/ecological sciences.

Operator (computer programming)

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