Search This Blog

Sunday, October 18, 2026

Environmental health

From Wikipedia, the free encyclopedia

Conceptual map illustrating the connections among nonhuman nature, ecosystem services, environmental ethics, environmental justice, and public health
Environmental health indicator (2016). It consists of three categories: health impacts, air quality, and water and sanitation. The health impacts category includes the environmental risk exposure indicator.

Environmental health is the branch of public health concerned with all aspects of the natural and built environment affecting human health. Its study determines the requirements for a healthy environment, with the goal of effective control over the factors that affect health. The major sub-disciplines of environmental health are environmental science, toxicology, environmental epidemiology, and environmental and occupational medicine.

Definitions

WHO definitions

Environmental health was defined in a 1989 document by the World Health Organization (WHO) as: Those aspects of human health and disease that are determined by factors in the environment. It is also referred to as the theory and practice of assessing and controlling factors in the environment that can potentially affect health.

As of 2016, the WHO website on environmental health states that "Environmental health addresses all the physical, chemical, and biological factors external to a person, and all the related factors impacting behaviours. It encompasses the assessment and control of those environmental factors that can potentially affect health. It is targeted towards preventing disease and creating health-supportive environments. This definition excludes behaviour not related to the environment, as well as behaviour related to the social and cultural environment, as well as genetics."

Environmental health also looks at how exposure to things like air pollution, water contamination, and chemicals can affect people's health over time.

Other considerations

The term environmental medicine may be seen as a medical specialty, or a branch of the broader field of environmental health. Terminology is not fully established, and in many European countries these are used interchangeably.

Other terms referring to or concerning environmental health include environmental public health and health protection.

Comparison of integrated approach in health

Origins Concept
Environmental health From the 1880s Sanitary Science
  • Anthropocentric approach on environment influence on human health.
One Health (legacy) Virchow and Osler (1800s) and Schwabe (1964) zoonosis
  • Collaboration of human medicine and veterinary.
One Medicine–One Health (modern) Early 2000s as response to emerging infectious diseases (SARS, MERS, Ebola)
  • Cross-sectoral and transdisciplinary collaboration to improve health of humans, animals and ecosystems because of inter-connectedness.
  • Recognizes the interconnectedness of human, animal, and environmental health.
  • Incorporates components of food safety, antimicrobial resistance, and environmental contaminations.
Conservation medicine 1990s as health gains importance in conservation
  • Connection of health of animals and humans and ecosystems in situ
Comparative medicine Since ancient time
  • Understanding shared or similar pathophysiological processes, which is fundamentals for medical and translational research
Ecohealth 1990s by French Canadian-based International Development Research Centre
  • Dependency of human and animal health and wellbeing on sustained environment.
  • Human and ecosystem health exists in socio-ecological interactions
Planetary health Introduced in 1970–80s, and repopularized by Lancet Commission and Rockefeller Foundation
  • Anthropomorphized view of impact and interconnectedness of humans with the Earth at all levels
One Welfare Emerged in 2015 for promotion of the links between animal welfare and human wellbeing
  • Highlights the interconnection of animal welfare, human wellbeing, and environment to foster interdisciplinary collaboration in order to improve human and animal welfare
Beyond One Ocean Health (B1OH) Impacts of environmental change on health of ecosystems and organisms with emphasis on ocean
  • Highlights transdisciplinary actions on aquatic ecosystems, interconnected integrated systems and health through sustainable developments
  • Links healthy ocean with health and equity.
Public health
  • Population-based (instead of individual)
  • Focus on health promotion and prevention (instead of treatment and rehabilitation)
  • Social, cultural, economic, political, and environmental determinant of health
Global health Supraterritoriality of health
  • Transboundary health threats

Disciplines

Five basic disciplines generally contribute to the field of environmental health, with some overlap between them:

  • Environmental epidemiology studies the relationship between environmental exposures (including exposure to chemicals, radiation, microbiological agents, etc.) and human health. Observational studies, which simply observe exposures that people have already experienced, are common in environmental epidemiology because humans cannot ethically be exposed to agents that are known or suspected to cause disease. While the inability to use experimental study designs is a limitation of environmental epidemiology, this discipline directly observes effects on human health rather than estimating effects from animal studies. Environmental epidemiology is the study of the effect on human health of physical, biologic, and chemical factors in the external environment, broadly conceived. Also, examining specific populations or communities exposed to different ambient environments, Epidemiology in our environment aims to clarify the relationship that exist between physical, biologic or chemical factors and human health.
  • Toxicology studies how environmental exposures lead to specific health outcomes, generally in animals, as a means to understand possible health outcomes in humans. Toxicology has the advantage of being able to conduct randomized controlled trials and other experimental studies because it can use animal subjects. However, there are many differences in animal and human biology, and there can be a lot of uncertainty when interpreting the results of animal studies for their implications for human health.
  • Exposure science studies human exposure to environmental contaminants by both identifying and quantifying exposures. Exposure science can be used to support environmental epidemiology by better describing environmental exposures that may lead to a particular health outcome, identify common exposures whose health outcomes may be better understood through a toxicology study, or can be used in a risk assessment to determine whether current levels of exposure might exceed recommended levels. Exposure science has the advantage of being able to very accurately quantify exposures to specific chemicals, but it does not generate any information about health outcomes like environmental epidemiology or toxicology.
  • Environmental engineering applies scientific and engineering principles for protection of human populations from the effects of adverse environmental factors; protection of environments from potentially deleterious effects of natural and human activities; and general improvement of environmental quality.
  • Environmental law includes the network of treaties, statutes, regulations, common and customary laws addressing the effects of human activity on the natural environment.

Information from epidemiology, toxicology, and exposure science can be combined to conduct a risk assessment for specific chemicals, mixtures of chemicals or other risk factors to determine whether an exposure poses significant risk to human health (exposure would likely result in the development of pollution-related diseases). This can in turn be used to develop and implement environmental health policy that, for example, regulates chemical emissions, or imposes standards for proper sanitation. Intervention strategies from engineering and law can be combined to provide monitoring and risk management of exposure, and achieve the objective of protecting human health.

Pediatric environmental health

Children's environmental health is the academic discipline that studies how environmental exposures in early life—chemical, biological, nutritional, and social—influence health and development in childhood and across the entire human life span. Pediatric environmental health is based on the recognition that children are not "little adults." Infants and children have unique patterns of exposure and vulnerabilities. Environmental risks of infants and children are qualitatively and quantitatively different from those of adults. Pediatric environmental health is highly interdisciplinary. It spans and brings together general pediatrics and numerous pediatric subspecialties as well as epidemiology, occupational and environmental medicine, medical toxicology, industrial hygiene, and exposure science.

Concerns

Overview of main health effects on humans from some common types of pollution
FEMA/EPA Hazardous Materials Team removing hazards left in the wake of Hurricane Katrina, 2005

Environmental health concerns include:

According to recent estimates in Europe, about 5 to 10% of disability-adjusted life years (DALYs) lost are due to environmental causes. By far the most important factor is fine particulate matter pollution in urban air. Similarly, environmental exposures have been estimated to contribute to 4.9 million (8.7%) deaths and 86 million (5.7%) DALYs globally. In the United States, Superfund sites created by various companies have been found to be hazardous to human and environmental health in nearby communities. It was this perceived threat, raising the specter of miscarriages, mutations, birth defects, and cancers that most frightened the public.

Air quality

Air quality includes ambient outdoor air quality and indoor air quality. Large concerns about air quality include environmental tobacco smoke, air pollution by forms of chemical waste, and other concerns.

Outdoor air quality

Air pollution is globally responsible for over 6.5 million deaths each year, as of 2022. Air pollution is often a risk-factor for diseases like lung cancer, respiratory infections, asthma, heart disease, and other forms of respiratory-related illnesses. Reducing air pollution, and thus developing air quality, has been found to decrease adult mortality.

A Mumbai factory releasing air pollution.

Common products responsible for emissions include road traffic, energy production, household combustion, aviation and motor vehicles, and other forms of pollutants. These pollutants are responsible for the burning of fuel, which can release harmful particles into the air that humans and other living organisms can inhale or ingest.

Air pollution is associated with adverse health effects like respiratory and cardiovascular diseases, cancer, related illnesses, and even death. The risk of air pollution is determined by the pollutant's hazard and the amount of exposure that affects a person. For example, a child who plays outdoor sports will have a higher likelihood of outdoor air pollution exposure than an adult who tends to spend more time indoors, whether at work or elsewhere. Environmental health officials work to detect individuals who are at higher risk of exposure to air pollution, detect risk factors present in communities, and work to decrease overall community exposure.

Indoor air quality

Household air pollution contributes to diseases that kill almost 4.3 million people every year, as of 2014. Indoor air pollution contributes to risk factors for diseases like heart disease, pulmonary disease, stroke, pneumonia, and other associated illnesses. For vulnerable populations, such as children and elderly populations, who spend large amounts of their time indoors, poor indoor air quality can be dangerous.

Burning fuels like coal or kerosene inside homes can cause dangerous chemicals to be released into the air. Dampness and mold in houses can cause diseases, but few studies have been performed on mold in schools and workplaces. Environmental tobacco smoke is considered to be a leading contributor to indoor air pollution since exposure to second and third-hand smoke is a common risk factor. Tobacco smoke contains over 60 carcinogens, where 18% are known human carcinogens. Exposure to these chemicals can lead to exacerbation of asthma, the development of cardiovascular diseases and cardiopulmonary diseases, and an increase in the likelihood of cancer development.

Climate change and its effects on health

Climate change, in addition to its other effects, makes extreme weather events more likely, including ozone smog events, dust storms, and elevated aerosol levels, all due to extreme heat, drought, winds, and rainfall. These extreme weather events can increase the likelihood of undernutrition, mortality, food insecurity, and climate-sensitive infectious diseases in vulnerable populations. The effects of climate change are felt by the whole world, but disproportionately affect disadvantaged populations who are subject to climate change vulnerability.

Water runoff in Maryland, USA.

Climate impacts can affect exposure to water-borne pathogens through increased rates of runoff, frequent heavy rains, and the effects of severe storms. Extreme weather events and storm surges can also exceed the capacity of water infrastructure, which can increase the likelihood that populations will be exposed to these contaminants. Exposure to these contaminants are more likely in low-income communities, where they have inadequate infrastructure to respond to climate disasters and are less likely to recover from infrastructure damage as quickly.

Problems like the loss of homes, loved ones, and previous ways of life are often what people face after a climate disaster occurs. These events can lead to vulnerability in the form of housing affordability stress, lower household income, lack of community attachment, grief, and anxiety around another disaster occurring.

Environmental racism

Certain groups of people can be put at a higher risk for environmental hazards like air, soil and water pollution. This often happens due to marginalization, economic and political processes, and racism. Environmental racism uniquely affects different groups globally; however generally the most marginalized groups of any region are most affected. These marginalized groups are frequently put next to pollution sources like major roadways, toxic waste sites, landfills, and chemical plants. In a 2021 study, it was found that racial and ethnic minority groups in the United States are exposed to disproportionately high levels of particulate air pollution. Racial housing policies that exist in the United States continue to exacerbate racial minority exposure to air pollution at a disproportionate rate, even as overall pollution levels have declined. Likewise, in a 2022 study, it was shown that implementing policy changes that favor wealth redistribution could double as climate change mitigation measures. For populations who are not subject to wealth redistribution measures, this means more money will flow into their communities while climate effects are mitigated.

Noise pollution

Airplane flying over a residential district.

Noise pollution is usually environmental, machine-created sound that can disrupt activities or communication between humans and other forms of life. Exposure to persistent noise pollution can cause numerous ailments like hearing impairment, sleep disturbances, cardiovascular problems, annoyance, problems with communication and other diseases. For American minorities that live in neighborhoods of low socioeconomic status, they often experience higher levels of noise pollution compared to their higher socioeconomic counterparts.

Noise pollution can cause or exacerbate cardiovascular diseases, which can further contribute to a larger range of diseases, increase stress levels, and cause sleep disturbances. Noise pollution is also responsible for many reported cases of hearing loss, tinnitus, and other forms of hypersensitivity(stress/irritability) or lack thereof to sound(present or subconscious from continuous exposure). These conditions can be dangerous to children and young adults who consistently experience noise pollution, as many of these conditions can develop into long-term problems, including physical and mental health issues.

Children who attend school in noisy traffic zones have been shown to have 15% lower memory development compared to other students who attended schools in quiet traffic zones, according to a Barcelona study. This is consistent with research that suggests that children who are exposed to regular aircraft noise "have inadequate performance on standardised achievement tests."

Exposure to persistent noise pollution can cause one to develop hearing impairments, like tinnitus or impaired speech discrimination. One of the largest factors in worsened mental health due to noise pollution is annoyance. Annoyance due to environmental factors has been found to increase stress reactions and overall feelings of stress among adults. The level of annoyance felt by an individual varies, but contributes significantly to worsened mental health.

Noise exposure also contributes to sleep disturbances, which can cause daytime sleepiness and an overall lack of sleep, which contributes to worsened health. Daytime sleepiness has been linked to several reports of declining mental health and other health issues, job insecurity and further social and environmental factors declining.

Safe drinking water

Well installation for safe drinking water.

Access to safe drinking water is considered a "basic human need for health and well-being" by the United Nations. According to their reports, over 2 billion people worldwide live without access to safe drinking water. In 2017, almost 22 million Americans drank from water systems that violated public health standards. Globally, over 2 billion people drink feces-contaminated water, which poses the greatest threat to drinking water safety. Contaminated drinking water could transmit diseases like cholera, dysentery, typhoid, diarrhea and polio.

Harmful chemicals in drinking water can negatively affect health. Unsafe water management practices can increase the prevalence of water-borne diseases and sanitation-related illnesses. Inadequate disinfecting of wastewater in industrial and agricultural centers can also infect hundreds of millions of people with contaminated water. Chemicals like fluoride and arsenic can benefit humans when the levels of these chemicals are controlled; but other, more dangerous chemicals like lead and other heavy metals can be harmful to humans.

In America, communities of color can be subject to poor-quality water. In communities in America with large Hispanic and black populations, there is a correlated rise in SDWA health violations. Populations who have experienced a lack of safe drinking water, like populations in Flint, Michigan, are more likely to distrust tap water in their communities. Populations that experience this are commonly low-income communities of color.

Hazardous materials management

Hazardous materials management, including hazardous waste management, contaminated site remediation, the prevention of leaks from underground storage tanks and the prevention of hazardous materials releases to the environment and responses to emergencies resulting from such releases. When hazardous materials are not managed properly, waste can pollute nearby water sources and reduce air quality.

According to a study done in Austria, people who live near industrial sites are "more often unemployed, have lower education levels, and are twice as likely to be immigrants. With the interest of environmental health in mind, the Resource Conservation and Recovery Act was passed in the United States in 1976 which covered how to properly manage hazardous waste.

There are a variety of occupations that work with hazardous materials and help manage them so that everything is disposed of correctly. These professionals work in various sectors, including government agencies, private industry, consulting firms, and non-profit organizations, all with the common goal of ensuring the safe handling of hazardous materials and waste. These positions include but are not limited to Environmental Health and Safety Specialists, Waste collectors, Medical Professionals, and Emergency Responders. Handling waste, especially hazardous materials is considered one of the most dangerous occupations in the world. Often, these workers may not have all the information about the specific hazardous materials they encounter, making their jobs even more dangerous. The sudden exposure to materials they are not properly prepared to handle can lead to severe consequences. This emphasizes the importance of training, safety protocols, and the use of personal protective equipment for those working with hazardous waste.

Microplastic pollution

Humans are exposed to toxic chemicals and microplastics at all stages in the plastics life cycle.
Microplastics shown under a microscope at 100x magnification

The effects of microplastics on human health are a subject of ongoing study. These extremely small plastic particles originate from larger plastics and have been detected in high volumes in human biological samples, air, water, and food. This has raised concerns about the long-term impacts on human health.

Plastic particles smaller than 5mm are considered microplastics (MPs). Particles smaller than 1μm are nanoplastics (NP), which are too small to be seen by the human eye. Nanoplastics remain less studied than larger plastic debris, and their long-term health impacts are still being investigated. Given their minute size, nanoplastics can penetrate biological barriers and accumulate in human tissues, raising questions about potential health effects.

Micro- and nanoplastics (MNPs) have been detected in multiple organs and tissues, as well as human feces, urine, breastmilk, and neonatal meconium, suggesting widespread exposure and absorption. Larger MNPs are thought to be filtered out by normal bodily defenses, such as by mucus in the nose or by coughing. However, "ultrafine" particles are able to enter the circulatory system through the lungs. Additionally, when MNPs are introduced directly into the bloodstream, such as during medical treatment, they bypass our natural defenses.

Although experimental studies within cell cultures and animals have shown possible biological effects, human evidence remains limited, and long-term health risks are still being researched. A 2024 systematic review of human and animal observational studies concluded that MNPs are "suspected" to be harmful to human reproductive, respiratory, and digestive health.

The World Health Organization has acknowledged growing concerns, but note that standardized measurement methods and risks have not been established, calling for further research and improved management of plastic throughout its life-cycle.

Soil pollution

Contaminated or polluted soil directly affects human health through direct contact with soil or via inhalation of soil contaminants that have vaporized. Potentially greater threats are posed by the infiltration of soil contaminants into groundwater aquifers used for irrigation or direct human consumption, sometimes in areas far from any apparent source of above-ground contamination (long-range diffuse soil contamination). Toxic metals can also make their way up the food chain through plants that reside in soils containing high concentrations of heavy metals. This tends to result in the development of pollution-related diseases.

Most exposure to soil contamination is accidental, and can happen through:

  • Ingesting dust or soil directly
  • Ingesting food or vegetables grown in contaminated soil or with foods in contact with contaminants
  • Skin contact with dust or soil
  • Vapors from the soil
  • Inhaling clouds of dust while working in soils or windy environments

However, some studies estimate that 90% of human exposure is through eating contaminated food.

Information and mapping

The Toxicology and Environmental Health Information Program (TEHIP) is a comprehensive toxicology and environmental health web site that includes open access to resources produced by US government agencies and organizations, maintained under the umbrella of the Specialized Information Service at the United States National Library of Medicine. TEHIP was responsible for the Toxicology Data Network (TOXNET), an integrated system of toxicology and environmental health databases including the Hazardous Substances Data Bank, that was open access. TOXNET was retired in 2019.

There are many environmental health mapping tools. TOXMAP is a geographic information system (GIS) from the Division of Specialized Information Services of the United States National Library of Medicine (NLM) that uses maps of the United States to help users visually explore data from the United States Environmental Protection Agency's (EPA) Toxics Release Inventory and Superfund Basic Research Programs. TOXMAP is a resource funded by the US federal government. TOXMAP's chemical and environmental health information is taken from the NLM's Toxicology Data Network (TOXNET) and PubMed, and from other authoritative sources.

Environmental health profession

Environmental health professionals may be known as environmental health officers, public health inspectors, environmental health specialists or environmental health practitioners. Researchers and policy-makers also play important roles in how environmental health is practiced in the field. In many European countries, physicians and veterinarians are involved in environmental health. Many countries require graduate degrees and professional licenses to practice environmental health.

The environmental health profession had its modern-day roots in the sanitary and public health movement of the United Kingdom. This was epitomized by Sir Edwin Chadwick, who was instrumental in the repeal of the poor laws, and in 1884 was the founding president of the Association of Public Sanitary Inspectors, now called the Chartered Institute of Environmental Health.

Exposome

From Wikipedia, the free encyclopedia
https://en.wikipedia.org/wiki/Exposome
Example representation of the environmental factors characterizing the exposome

The exposome is a concept used to describe environmental exposures that an individual encounters throughout life, and how these exposures impact biology and health. It encompasses both external and internal factors, including chemical, physical, biological, and social factors that may influence human health. In 2023, the Banbury Exposomic Consortium established a consensus definition of the exposome as, "Briefly, the exposome is posited as an integrated compilation of all physical, chemical, biological, and (psycho)social influences that 'impact biology'. The field of exposomics thus examines the comprehensive and cumulative effects of these factors by integrating data from interdisciplinary methodologies and data streams to drive discovery".

The study of the exposome has become a useful tool in understanding the interplay between genetics and environmental factors in the development of diseases, with a particular focus on chronic conditions. The concept has been widely applied in fields such as epidemiology, toxicology, and public health, among others, and has led to significant advances in our understanding of disease etiology and prevention.

By considering the cumulative effect of multiple exposures, it provides a holistic approach to the study of gene-environment interactions, allowing for a more accurate assessment of disease risk and the identification of potential intervention strategies.

Environmental exposures can have a significant impact on an individual's health. Exposure to air pollution, for example, has been linked to an increased risk of respiratory disease, heart disease, and even premature death. Similarly, exposure to certain chemicals in consumer products has been linked to an increased risk of cancer and other health problems. In addition to external factors, the internal exposome can also influence an individual's health outcomes. For example, genetics can play a role in how an individual's body processes and responds to environmental exposures, while the gut microbiome can affect an individual's immune system and overall health. As our understanding of the exposome continues to evolve, it is likely that we will gain new insights into the complex interplay between our environment and our health.

History

The term "exposome" was coined in 2005 by Dr. Christopher Wild, then Professor of Molecular Epidemiology at the University of Leeds UK, in a seminal paper published in Cancer Epidemiology, Biomarkers & Prevention. Wild's concept was initially proposed to complement the human genome, as he recognized the limitations of genetic research in explaining the etiology of chronic diseases. By suggesting a systematic approach to measuring environmental exposures, the exposome aimed to fill this knowledge gap.

Various definitions of the exposome have been proposed over time, but most emphasize three main components: the external exposome, the internal exposome, and the biological response. The external exposome includes general external factors, such as air pollution, diet, and socioeconomic factors, as well as specific external factors like chemicals and radiation. The internal exposome comprises endogenous factors, such as hormones, inflammation, oxidative stress, and gut microbiota. Finally, the biological response refers to the complex interactions between the external and internal exposome factors and their influence on an individual's physiology and health.

Significance

The field of exposome research is relatively new and rapidly evolving, and is still being developed and refined by researchers in a variety of fields, including epidemiology, environmental health, and genomics. Understanding the exposome is important because it can help researchers identify the environmental factors that contribute to disease, and develop strategies for prevention and treatment.

The exposome concept presents several challenges for researchers. One of the main challenges is the complexity and diversity of exposures that individuals experience throughout their lifetime. There are thousands of chemicals in the environment, and individuals are exposed to different combinations of chemicals depending on their location, occupation, and lifestyles. Besides this, a lack of standardized methods for measuring exposures is also challenging. Traditional approaches to measuring environmental exposures have relied on individual exposure assessments, which are often expensive and time-consuming. To address this challenge, new technologies—such as high-throughput methods for measuring multiple exposures simultaneously and spatial exposomics— are being developed.

Understanding exposomes has significant implications for public health and the development of more effective strategies for prevention and treatment of disease. For example, if research shows that exposure to a certain chemical is linked to an increased risk of cancer, policymakers can take steps to regulate or ban the use of that chemical.

In addition to informing public health policies, the study of the exposome can also help individuals make more informed choices about their own health. By understanding the environmental factors that contribute to disease, individuals can take steps to reduce their exposure to harmful substances and improve their overall health.

The exposome concept holds promise for advancing understanding of the interplay between environmental exposures and human health. As researchers continue to refine exposure assessment methods, identify novel biomarkers, and develop computational approaches, the exposome framework is poised to revolutionize the fields of epidemiology, toxicology, and public health.

Global initiatives

There are several research initiatives aimed to better understand the exposome. In the United States, "NEXUS: Network for Exposomics in the U.S. Coordinating Center" (NEXUS) was established in 2024 by the U.S. National Institutes of Health (NIH), along with the NIH centers for research ongoing on the human exposome. NEXUS is a coordinating center and a movement to how our environments, or the exposome, shape human health, with a goal to transform the entire biomedical enterprise.

The Gateway Exposome Coordinator Center (GECC) is another United States based initiative aimed to advance life course research on the Alzheimer’s disease and related dementia (AD/ADRD) exposome. The GECC is funded by the National Institute on Aging (NIA) U24AG088894.

Additionally, Mount Sinai's Institute for Exposomic Research organizes an international series of symposia focused on Exposomics, Aging, and Alzheimer's Disease Across the Life Course. These symposia are funded by the National Institutes on Aging to promote international research in ADRD Exposomic Research and address the role of environment in aging processes globally.

Other global initiatives include the 2025 Exposome Moonshot Forum which brought together diverse stakeholders from industry, academia, and government to chart the future of the Human Exposome. This meeting led to the formation of the Global Exposome Forum which is an emerging coalition of organizations and individuals working toward the same goals of advancing new research, capacity and network building, and facilitating institutional support for a future informed by exposomics.

Also held in 2025 was the Genomics Meets Exposomics: Advancing Gene x Environment Science conference which was held at the Mendel Museum in Brno, Czech Republic and was co-led by NEXUS and EIRENE. The meeting aimed to develop an action plan for the advancement of gene-by-environment studies to better understand human disease. The meeting brought together 35 participants at the forefront of genomics and exposomics, as well as those whose work spans transitional and clinical research, big data and AI, population sciences, toxicology, and the social sciences - in order to deepen engagement with those in the genetics community and European scientists to address the critical need of merging methods, techniques, and expertise in exposomics and genomics to provide a foundation for systematic gene-by-environment studies.

Other initiatives include the "Enhanced exposure assessment and omic profiling for high priority environmental exposures in Europe", a program by the Imperial College of Science, Technology and Medicine in the UK. A current initiative is EXIMIOUS - a 5-year Research and Innovation Action funded by the European Union's Horizon 2020 program, aimed at introducing a new approach to mapping exposure-induced immune effects by combining exposomics and immunomics in a unique toolbox. Another is the National Institutes of Health's Environmental Influences on Child Health Outcomes (ECHO) program, which is studying the impact of these factors on children's health. We also have the Human Exposome Project, a collaborative effort between researchers from around the world to develop tools and techniques to measure and analyze the exposome.

Furthermore, several European countries, including Sweden, France, Austria, and Czechia, have been actively involved in establishing dedicated research infrastructures for exposomics. In Sweden, the National Facility for Exposomics was approved in November 2020 and is hosted by the University of Stockholm. The facility is currently operational in Solna, providing resources and expertise for exposomics research. France has also established a dedicated research infrastructure, France Exposome, a new National Research Infrastructure that focuses on environmental health. It has been included in the 2021 roadmap for the research infrastructure of the Ministry of Higher Education and Research, indicating its significance in the country's research landscape.

Additionally, the Environmental Exposure Assessment Research Infrastructure (EIRENE) is a collaborative effort consisting of 17 National Nodes representing around 50 institutions with complementary expertise. EIRENE aims to fill the gap in the European infrastructural landscape and pioneer the first EU infrastructure on the human exposome. The consortium has a geographically balanced network, covering Northern (Finland, Iceland, Norway, Sweden), Western (Belgium, France, Germany, Netherlands, UK), Southern (Greece, Italy, Slovenia, Spain), and Central and Eastern (Austria, Czech Republic, Slovakia) Europe, as well as the US. The EIRENE RI team consists of scientists leading exposome research on an international level.

These initiatives reflect the growing recognition of the importance of exposomics research and the commitment of these countries to advancing the field. The establishment of dedicated research infrastructures ensures the availability of resources and expertise required to uncover crucial insights into the impact of exposomes on human health.

Methodologies

The study of the exposome requires a multi-disciplinary approach that combines advances in exposure assessment, bioinformatics, and systems biology. As such, researchers have developed a range of key methodologies to measure and analyze the exposome – from exposure assessment techniques, analytical tools, to computational approaches.

These methods are designed to capture and analyze the diverse and dynamic nature of environmental exposures across a person's lifespan.

Exposure assessment

The assessment of environmental exposures is a critical aspect of exposome research. Traditional methods, such as questionnaires and environmental monitoring, provide useful information on external factors but may not adequately capture the complexity and variability of exposures over time.

Consequently, researchers have increasingly turned to personal monitoring devices, such as wearable sensors, personal monitoring devices, and smartphone applications, which can collect real-time data on an individual's exposure to various environmental factors, such as air pollution, noise, and ultraviolet radiation. The data collected by these devices can help researchers understand how personal behaviors and microenvironments contribute to overall exposome profiles.

Biomarkers

Biomarkers (measurable indicators of biological processes or conditions) play an essential role in characterizing the internal exposome and biological response. This approach involves the measurement of chemicals or their metabolites in biological specimens such as blood, urine, or tissues. Advances in high-throughput -omics technologies such as genomics, transcriptomics, proteomics, and metabolomics, have revolutionized our ability to measure thousands of biomarkers simultaneously. This can provide a detailed snapshot of an individual's molecular profile at a given time, as well as a comprehensive view of the individual's biological response to environmental exposures. These technologies yield a direct and quantitative assessment of an individual's exposure to specific compounds and have been increasingly incorporated into exposome research and epidemiological studies.

Geographic Information Systems (GIS)

GIS tools can be used to estimate an individual's exposure to environmental factors based on spatial data, such as air pollution or proximity to hazardous waste sites. GIS-based exposure assessment has been applied in numerous epidemiological studies to investigate the relationship between environmental exposures and health outcomes.

Computational approaches

The vast amounts of data generated by exposome research require advanced computational methods for storage, analysis, and interpretation. Machine learning and other data mining techniques have emerged as valuable tools for identifying patterns and relationships within complex exposome data sets. Furthermore, systems biology approaches, which integrate data from multiple -omics platforms can help elucidate the complex interactions between exposures and biological pathways that contribute to disease development.

Applications

Epidemiology

Exposome research has had a significant impact on the field of epidemiology, providing new insights into the complex relationships between environmental exposures, genetic factors, and human health. By comprehensively assessing the totality of exposures, epidemiologists can better understand the etiology of chronic diseases, such as cancer, cardiovascular disease, and neurodegenerative disorders, and identify modifiable risk factors that may be targets for intervention.

Large-scale exposome projects, such as the Human Early-Life Exposome (HELIX) project and the European Exposome Cluster, have been established to investigate these relationships and generate new knowledge on disease etiology and prevention.

Toxicology

The exposome has also influenced the field of toxicology, leading to the development of new methods for assessing the cumulative effects of multiple environmental exposures on human health. By integrating exposure data with molecular profiling techniques, toxicologists can better understand the mechanisms through which environmental chemicals and other factors contribute to adverse health outcomes. This knowledge can inform the development of more effective strategies for chemical risk assessment and regulation.

Public health

Public health research and practice have greatly benefited from the insights gained through exposome research. By elucidating the complex interactions between environmental exposures and human health, the exposome framework can inform the design of targeted interventions to reduce disease risk and promote health equity.

Moreover, the development of exposome-based tools, such as biomonitoring and personal exposure monitoring devices, can help public health practitioners better track population exposures and evaluate the effectiveness of interventions.

Challenges and future directions

Despite significant advances in exposome research, several challenges remain, including the development of more accurate exposure assessment techniques, the identification of novel biomarkers, and the management of large- scale and complex data sets.

Exposure assessment

One of the main challenges in exposome research is the accurate assessment of exposures across an individual's lifetime. While recent technological advancements have improved our ability to measure environmental exposures in real-time, there is still a need for methods that can retrospectively assess historical exposures, particularly in the context of chronic disease research.

Biomarker identification

Another challenge lies in the identification of novel and informative biomarkers that can provide insights into the biological pathways underlying exposure-disease relationships. While omics technologies have greatly expanded the number of measurable biomarkers, researchers must still determine which of these markers are most relevant to specific health outcomes and how they may be affected by various exposures.

Data management

Exposome research generates vast amounts of complex data, posing challenges related to data storage, analysis, and interpretation. As the field continues to grow, the development of standardized data formats, data sharing platforms, and advanced computational methods for data integration will be crucial to maximizing the potential of exposome research

Anti-gender movement

From Wikipedia, the free encyclopedia https://en.wikipedia.org/wiki/Anti-gender_movement This article is...