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Some of the major unsolved problems in physics are theoretical, meaning that existing theories seem incapable of explaining a certain observed phenomenon or experimental result. The others are experimental, meaning that there is a difficulty in creating an experiment to test a proposed theory or investigate a phenomenon in greater detail.
 
There are still some deficiencies in the Standard Model of physics, such as the origin of mass, the strong CP problem, neutrino oscillations, matter–antimatter asymmetry, and the nature of dark matter and dark energy. Another problem lies within the mathematical framework of the Standard Model itself—the Standard Model is inconsistent with that of general relativity, to the point that one or both theories break down under certain conditions (for example within known spacetime singularities like the Big Bang and the centers of black holes beyond the event horizon).

Unsolved problems by subfield